-- dump date 20140618_202839 -- class Genbank::misc_feature -- table misc_feature_note -- id note 713604000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604000002 Walker A motif; other site 713604000003 ATP binding site [chemical binding]; other site 713604000004 Walker B motif; other site 713604000005 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 713604000006 DnaA box-binding interface [nucleotide binding]; other site 713604000007 DNA polymerase III subunit beta; Validated; Region: PRK07761 713604000008 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 713604000009 putative DNA binding surface [nucleotide binding]; other site 713604000010 dimer interface [polypeptide binding]; other site 713604000011 beta-clamp/clamp loader binding surface; other site 713604000012 beta-clamp/translesion DNA polymerase binding surface; other site 713604000013 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604000014 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 713604000015 recombination protein F; Reviewed; Region: recF; PRK00064 713604000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 713604000017 Walker A/P-loop; other site 713604000018 ATP binding site [chemical binding]; other site 713604000019 Q-loop/lid; other site 713604000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604000021 ABC transporter signature motif; other site 713604000022 Walker B; other site 713604000023 D-loop; other site 713604000024 H-loop/switch region; other site 713604000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 713604000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 713604000027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 713604000028 anchoring element; other site 713604000029 dimer interface [polypeptide binding]; other site 713604000030 ATP binding site [chemical binding]; other site 713604000031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 713604000032 active site 713604000033 putative metal-binding site [ion binding]; other site 713604000034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 713604000035 DNA gyrase subunit A; Validated; Region: PRK05560 713604000036 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 713604000037 CAP-like domain; other site 713604000038 active site 713604000039 primary dimer interface [polypeptide binding]; other site 713604000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000046 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 713604000047 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604000048 active site 713604000049 DNA binding site [nucleotide binding] 713604000050 Int/Topo IB signature motif; other site 713604000051 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604000052 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 713604000053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604000054 non-specific DNA binding site [nucleotide binding]; other site 713604000055 salt bridge; other site 713604000056 sequence-specific DNA binding site [nucleotide binding]; other site 713604000057 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604000058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604000059 non-specific DNA binding site [nucleotide binding]; other site 713604000060 salt bridge; other site 713604000061 sequence-specific DNA binding site [nucleotide binding]; other site 713604000062 HEAT repeats; Region: HEAT_2; pfam13646 713604000063 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604000064 active site 713604000065 metal binding site [ion binding]; metal-binding site 713604000066 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604000067 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 713604000068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604000069 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604000070 Walker A/P-loop; other site 713604000071 ATP binding site [chemical binding]; other site 713604000072 Q-loop/lid; other site 713604000073 ABC transporter signature motif; other site 713604000074 Walker B; other site 713604000075 D-loop; other site 713604000076 H-loop/switch region; other site 713604000077 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604000078 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604000079 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604000080 DNA binding site [nucleotide binding] 713604000081 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604000082 Predicted ATPase [General function prediction only]; Region: COG3903 713604000083 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604000084 Cytochrome P450; Region: p450; cl12078 713604000085 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 713604000086 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 713604000087 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604000088 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 713604000089 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 713604000090 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 713604000091 active site 713604000092 Rhomboid family; Region: Rhomboid; pfam01694 713604000093 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 713604000094 putative septation inhibitor protein; Reviewed; Region: PRK00159 713604000095 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 713604000096 active site 713604000097 catalytic site [active] 713604000098 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604000099 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604000100 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 713604000101 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604000102 Walker A/P-loop; other site 713604000103 ATP binding site [chemical binding]; other site 713604000104 Q-loop/lid; other site 713604000105 ABC transporter signature motif; other site 713604000106 Walker B; other site 713604000107 D-loop; other site 713604000108 H-loop/switch region; other site 713604000109 Putative sensor; Region: Sensor; pfam13796 713604000110 Histidine kinase; Region: HisKA_3; pfam07730 713604000111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604000112 ATP binding site [chemical binding]; other site 713604000113 Mg2+ binding site [ion binding]; other site 713604000114 G-X-G motif; other site 713604000115 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604000116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604000117 active site 713604000118 phosphorylation site [posttranslational modification] 713604000119 intermolecular recognition site; other site 713604000120 dimerization interface [polypeptide binding]; other site 713604000121 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604000122 DNA binding residues [nucleotide binding] 713604000123 dimerization interface [polypeptide binding]; other site 713604000124 ferredoxin-NADP+ reductase; Region: PLN02852 713604000125 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604000126 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 713604000127 Glutamine amidotransferase class-I; Region: GATase; pfam00117 713604000128 glutamine binding [chemical binding]; other site 713604000129 catalytic triad [active] 713604000130 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604000131 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604000132 Walker A/P-loop; other site 713604000133 ATP binding site [chemical binding]; other site 713604000134 Q-loop/lid; other site 713604000135 ABC transporter signature motif; other site 713604000136 Walker B; other site 713604000137 D-loop; other site 713604000138 H-loop/switch region; other site 713604000139 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 713604000140 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604000141 active site 713604000142 ATP binding site [chemical binding]; other site 713604000143 substrate binding site [chemical binding]; other site 713604000144 activation loop (A-loop); other site 713604000145 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604000146 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604000147 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604000148 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604000149 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604000150 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604000151 active site 713604000152 ATP binding site [chemical binding]; other site 713604000153 substrate binding site [chemical binding]; other site 713604000154 activation loop (A-loop); other site 713604000155 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 713604000156 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 713604000157 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 713604000158 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 713604000159 active site 713604000160 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 713604000161 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 713604000162 phosphopeptide binding site; other site 713604000163 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 713604000164 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 713604000165 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 713604000166 phosphopeptide binding site; other site 713604000167 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604000168 cleavage site 713604000169 active site 713604000170 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604000171 active site 713604000172 substrate binding sites [chemical binding]; other site 713604000173 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 713604000174 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604000175 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604000176 active site 713604000177 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604000178 sugar binding site [chemical binding]; other site 713604000179 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 713604000180 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604000181 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604000182 catalytic residue [active] 713604000183 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604000184 active site 713604000185 putative catalytic site [active] 713604000186 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 713604000187 active site 713604000188 nucleophile elbow; other site 713604000189 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604000190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604000191 DNA-binding site [nucleotide binding]; DNA binding site 713604000192 FCD domain; Region: FCD; pfam07729 713604000193 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 713604000194 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 713604000195 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604000196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604000197 dimer interface [polypeptide binding]; other site 713604000198 conserved gate region; other site 713604000199 putative PBP binding loops; other site 713604000200 ABC-ATPase subunit interface; other site 713604000201 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604000202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604000203 dimer interface [polypeptide binding]; other site 713604000204 conserved gate region; other site 713604000205 putative PBP binding loops; other site 713604000206 ABC-ATPase subunit interface; other site 713604000207 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 713604000208 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604000209 Walker A/P-loop; other site 713604000210 ATP binding site [chemical binding]; other site 713604000211 Q-loop/lid; other site 713604000212 ABC transporter signature motif; other site 713604000213 Walker B; other site 713604000214 D-loop; other site 713604000215 H-loop/switch region; other site 713604000216 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604000217 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 713604000218 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604000219 Walker A/P-loop; other site 713604000220 ATP binding site [chemical binding]; other site 713604000221 Q-loop/lid; other site 713604000222 ABC transporter signature motif; other site 713604000223 Walker B; other site 713604000224 D-loop; other site 713604000225 H-loop/switch region; other site 713604000226 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604000227 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604000228 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604000229 NAD(P) binding site [chemical binding]; other site 713604000230 catalytic residues [active] 713604000231 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 713604000232 classical (c) SDRs; Region: SDR_c; cd05233 713604000233 NAD(P) binding site [chemical binding]; other site 713604000234 active site 713604000235 amidase; Provisional; Region: PRK07042 713604000236 Amidase; Region: Amidase; cl11426 713604000237 Transposase; Region: DEDD_Tnp_IS110; pfam01548 713604000238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 713604000239 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 713604000240 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604000241 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000242 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604000243 DNA binding residues [nucleotide binding] 713604000244 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 713604000245 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 713604000246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604000247 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604000248 NAD(P) binding site [chemical binding]; other site 713604000249 active site 713604000250 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 713604000251 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 713604000252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604000253 active site 713604000254 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 713604000255 FAD binding domain; Region: FAD_binding_4; pfam01565 713604000256 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 713604000257 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 713604000258 dimer interface [polypeptide binding]; other site 713604000259 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 713604000260 active site 713604000261 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604000262 substrate binding site [chemical binding]; other site 713604000263 catalytic residue [active] 713604000264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604000265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604000266 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604000267 beta-galactosidase; Region: BGL; TIGR03356 713604000268 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604000269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604000270 salt bridge; other site 713604000271 non-specific DNA binding site [nucleotide binding]; other site 713604000272 sequence-specific DNA binding site [nucleotide binding]; other site 713604000273 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604000274 Phosphotransferase enzyme family; Region: APH; pfam01636 713604000275 active site 713604000276 ATP binding site [chemical binding]; other site 713604000277 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604000278 Copper resistance protein D; Region: CopD; pfam05425 713604000279 CopC domain; Region: CopC; pfam04234 713604000280 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 713604000281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604000282 putative PBP binding loops; other site 713604000283 dimer interface [polypeptide binding]; other site 713604000284 ABC-ATPase subunit interface; other site 713604000285 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 713604000286 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 713604000287 Walker A/P-loop; other site 713604000288 ATP binding site [chemical binding]; other site 713604000289 Q-loop/lid; other site 713604000290 ABC transporter signature motif; other site 713604000291 Walker B; other site 713604000292 D-loop; other site 713604000293 H-loop/switch region; other site 713604000294 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 713604000295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604000296 dimer interface [polypeptide binding]; other site 713604000297 conserved gate region; other site 713604000298 putative PBP binding loops; other site 713604000299 ABC-ATPase subunit interface; other site 713604000300 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 713604000301 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 713604000302 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 713604000303 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604000304 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604000305 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604000306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604000307 S-adenosylmethionine binding site [chemical binding]; other site 713604000308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604000309 NAD(P) binding site [chemical binding]; other site 713604000310 active site 713604000311 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 713604000312 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 713604000313 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 713604000314 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604000315 active site 713604000316 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 713604000317 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 713604000318 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604000319 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604000320 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 713604000321 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604000322 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 713604000323 putative dimer interface [polypeptide binding]; other site 713604000324 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604000325 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604000326 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604000327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000328 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604000329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604000330 putative substrate translocation pore; other site 713604000331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604000332 salt bridge; other site 713604000333 non-specific DNA binding site [nucleotide binding]; other site 713604000334 sequence-specific DNA binding site [nucleotide binding]; other site 713604000335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604000336 Histidine kinase; Region: HisKA_3; pfam07730 713604000337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604000338 ATP binding site [chemical binding]; other site 713604000339 Mg2+ binding site [ion binding]; other site 713604000340 G-X-G motif; other site 713604000341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604000342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604000343 active site 713604000344 phosphorylation site [posttranslational modification] 713604000345 intermolecular recognition site; other site 713604000346 dimerization interface [polypeptide binding]; other site 713604000347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604000348 DNA binding residues [nucleotide binding] 713604000349 dimerization interface [polypeptide binding]; other site 713604000350 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 713604000351 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 713604000352 NADP-binding site; other site 713604000353 homotetramer interface [polypeptide binding]; other site 713604000354 substrate binding site [chemical binding]; other site 713604000355 homodimer interface [polypeptide binding]; other site 713604000356 active site 713604000357 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 713604000358 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604000359 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604000360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604000361 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604000362 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604000363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604000364 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604000365 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 713604000366 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604000367 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000368 Putative zinc-finger; Region: zf-HC2; pfam13490 713604000369 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 713604000370 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 713604000371 putative DNA binding site [nucleotide binding]; other site 713604000372 catalytic residue [active] 713604000373 putative H2TH interface [polypeptide binding]; other site 713604000374 putative catalytic residues [active] 713604000375 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604000376 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 713604000377 Histidine kinase; Region: His_kinase; pfam06580 713604000378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604000379 ATP binding site [chemical binding]; other site 713604000380 Mg2+ binding site [ion binding]; other site 713604000381 G-X-G motif; other site 713604000382 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 713604000383 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 713604000384 tandem repeat interface [polypeptide binding]; other site 713604000385 oligomer interface [polypeptide binding]; other site 713604000386 active site residues [active] 713604000387 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 713604000388 active site 713604000389 catalytic residues [active] 713604000390 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 713604000391 metal binding site [ion binding]; metal-binding site 713604000392 ligand binding site [chemical binding]; other site 713604000393 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 713604000394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604000395 active site 713604000396 phosphorylation site [posttranslational modification] 713604000397 intermolecular recognition site; other site 713604000398 dimerization interface [polypeptide binding]; other site 713604000399 LytTr DNA-binding domain; Region: LytTR; smart00850 713604000400 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604000401 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604000402 Na binding site [ion binding]; other site 713604000403 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 713604000404 active site residue [active] 713604000405 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 713604000406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604000407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604000408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604000409 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604000410 putative substrate translocation pore; other site 713604000411 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 713604000412 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604000413 Cytochrome P450; Region: p450; cl12078 713604000414 Protein of unknown function (DUF952); Region: DUF952; pfam06108 713604000415 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604000416 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000417 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604000418 DNA binding residues [nucleotide binding] 713604000419 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 713604000420 Ferritin-like domain; Region: Ferritin; pfam00210 713604000421 ferroxidase diiron center [ion binding]; other site 713604000422 arginine deiminase; Provisional; Region: PRK01388 713604000423 CAAX protease self-immunity; Region: Abi; pfam02517 713604000424 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604000425 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 713604000426 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604000427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604000428 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 713604000429 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604000430 metal ion-dependent adhesion site (MIDAS); other site 713604000431 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 713604000432 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604000433 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 713604000434 Protein of unknown function (DUF998); Region: DUF998; pfam06197 713604000435 Predicted membrane protein [Function unknown]; Region: COG2119 713604000436 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 713604000437 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 713604000438 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 713604000439 active site triad [active] 713604000440 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 713604000441 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 713604000442 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 713604000443 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 713604000444 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604000445 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 713604000446 Walker A/P-loop; other site 713604000447 ATP binding site [chemical binding]; other site 713604000448 ABC transporter; Region: ABC_tran; pfam00005 713604000449 Q-loop/lid; other site 713604000450 ABC transporter signature motif; other site 713604000451 Walker B; other site 713604000452 D-loop; other site 713604000453 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 713604000454 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 713604000455 Walker A/P-loop; other site 713604000456 ATP binding site [chemical binding]; other site 713604000457 Q-loop/lid; other site 713604000458 ABC transporter signature motif; other site 713604000459 Walker B; other site 713604000460 D-loop; other site 713604000461 H-loop/switch region; other site 713604000462 GAF domain; Region: GAF; cl17456 713604000463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604000464 Histidine kinase; Region: HisKA_3; pfam07730 713604000465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604000466 ATP binding site [chemical binding]; other site 713604000467 Mg2+ binding site [ion binding]; other site 713604000468 G-X-G motif; other site 713604000469 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604000470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604000471 active site 713604000472 phosphorylation site [posttranslational modification] 713604000473 intermolecular recognition site; other site 713604000474 dimerization interface [polypeptide binding]; other site 713604000475 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604000476 DNA binding residues [nucleotide binding] 713604000477 dimerization interface [polypeptide binding]; other site 713604000478 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 713604000479 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604000480 active site 713604000481 putative catalytic site [active] 713604000482 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 713604000483 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 713604000484 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 713604000485 active site 713604000486 catalytic site [active] 713604000487 substrate binding site [chemical binding]; other site 713604000488 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 713604000489 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 713604000490 homodimer interface [polypeptide binding]; other site 713604000491 chemical substrate binding site [chemical binding]; other site 713604000492 oligomer interface [polypeptide binding]; other site 713604000493 metal binding site [ion binding]; metal-binding site 713604000494 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604000495 pantothenate kinase; Provisional; Region: PRK05439 713604000496 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 713604000497 ATP-binding site [chemical binding]; other site 713604000498 CoA-binding site [chemical binding]; other site 713604000499 Mg2+-binding site [ion binding]; other site 713604000500 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 713604000501 ADP-ribose binding site [chemical binding]; other site 713604000502 prephenate dehydratase; Provisional; Region: PRK11898 713604000503 Prephenate dehydratase; Region: PDT; pfam00800 713604000504 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 713604000505 putative L-Phe binding site [chemical binding]; other site 713604000506 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604000507 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604000508 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 713604000509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604000510 putative substrate translocation pore; other site 713604000511 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 713604000512 Septum formation; Region: Septum_form; pfam13845 713604000513 Septum formation; Region: Septum_form; pfam13845 713604000514 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 713604000515 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 713604000516 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 713604000517 haloalkane dehalogenase; Provisional; Region: PRK00870 713604000518 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 713604000519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604000520 inhibitor-cofactor binding pocket; inhibition site 713604000521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604000522 catalytic residue [active] 713604000523 seryl-tRNA synthetase; Provisional; Region: PRK05431 713604000524 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 713604000525 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 713604000526 dimer interface [polypeptide binding]; other site 713604000527 active site 713604000528 motif 1; other site 713604000529 motif 2; other site 713604000530 motif 3; other site 713604000531 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 713604000532 Predicted dehydrogenase [General function prediction only]; Region: COG0579 713604000533 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604000534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604000535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604000536 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604000537 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604000538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604000539 non-specific DNA binding site [nucleotide binding]; other site 713604000540 salt bridge; other site 713604000541 sequence-specific DNA binding site [nucleotide binding]; other site 713604000542 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604000543 DNA binding site [nucleotide binding] 713604000544 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604000545 AAA ATPase domain; Region: AAA_16; pfam13191 713604000546 Predicted ATPase [General function prediction only]; Region: COG3903 713604000547 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 713604000548 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 713604000549 inhibitor-cofactor binding pocket; inhibition site 713604000550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604000551 catalytic residue [active] 713604000552 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604000553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604000554 NAD(P) binding site [chemical binding]; other site 713604000555 active site 713604000556 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604000557 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604000558 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 713604000559 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 713604000560 trimer interface [polypeptide binding]; other site 713604000561 active site 713604000562 substrate binding site [chemical binding]; other site 713604000563 CoA binding site [chemical binding]; other site 713604000564 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604000565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604000567 DNA binding residues [nucleotide binding] 713604000568 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 713604000569 Peptidase family M28; Region: Peptidase_M28; pfam04389 713604000570 putative metal binding site [ion binding]; other site 713604000571 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604000572 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604000573 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604000574 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 713604000575 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 713604000576 inhibitor-cofactor binding pocket; inhibition site 713604000577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604000578 catalytic residue [active] 713604000579 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604000580 putative trimer interface [polypeptide binding]; other site 713604000581 putative CoA binding site [chemical binding]; other site 713604000582 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 713604000583 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604000584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604000585 NAD(P) binding site [chemical binding]; other site 713604000586 active site 713604000587 AMP-binding enzyme; Region: AMP-binding; pfam00501 713604000588 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604000589 acyl-activating enzyme (AAE) consensus motif; other site 713604000590 AMP binding site [chemical binding]; other site 713604000591 active site 713604000592 CoA binding site [chemical binding]; other site 713604000593 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 713604000594 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604000595 NAD(P) binding site [chemical binding]; other site 713604000596 catalytic residues [active] 713604000597 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 713604000598 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604000599 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604000600 putative acyl-acceptor binding pocket; other site 713604000601 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 713604000602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604000603 active site 713604000604 motif I; other site 713604000605 motif II; other site 713604000606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604000607 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604000608 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604000609 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 713604000610 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604000611 UDP-galactopyranose mutase; Region: GLF; pfam03275 713604000612 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 713604000613 active site 713604000614 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 713604000615 short chain dehydrogenase; Provisional; Region: PRK07904 713604000616 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 713604000617 NAD(P) binding site [chemical binding]; other site 713604000618 active site 713604000619 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604000620 FAD binding domain; Region: FAD_binding_4; pfam01565 713604000621 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 713604000622 Predicted membrane protein [Function unknown]; Region: COG2246 713604000623 GtrA-like protein; Region: GtrA; pfam04138 713604000624 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604000625 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604000626 active site 713604000627 EspG family; Region: ESX-1_EspG; pfam14011 713604000628 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604000629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604000630 active site 713604000631 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 713604000632 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 713604000633 Walker A/P-loop; other site 713604000634 ATP binding site [chemical binding]; other site 713604000635 Q-loop/lid; other site 713604000636 ABC transporter signature motif; other site 713604000637 Walker B; other site 713604000638 D-loop; other site 713604000639 H-loop/switch region; other site 713604000640 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 713604000641 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604000642 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 713604000643 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604000644 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604000645 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604000646 catalytic residue [active] 713604000647 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 713604000648 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 713604000649 NAD(P) binding site [chemical binding]; other site 713604000650 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 713604000651 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 713604000652 PA/protease or protease-like domain interface [polypeptide binding]; other site 713604000653 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 713604000654 Peptidase family M28; Region: Peptidase_M28; pfam04389 713604000655 active site 713604000656 metal binding site [ion binding]; metal-binding site 713604000657 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604000658 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604000659 MarR family; Region: MarR; pfam01047 713604000660 MarR family; Region: MarR_2; cl17246 713604000661 Patatin-like phospholipase; Region: Patatin; pfam01734 713604000662 nucleophile elbow; other site 713604000663 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604000664 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604000665 active site 713604000666 metal binding site [ion binding]; metal-binding site 713604000667 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 713604000668 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 713604000669 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713604000670 RNA binding surface [nucleotide binding]; other site 713604000671 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 713604000672 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604000673 classical (c) SDRs; Region: SDR_c; cd05233 713604000674 NAD(P) binding site [chemical binding]; other site 713604000675 active site 713604000676 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 713604000677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604000678 active site 713604000679 phosphorylation site [posttranslational modification] 713604000680 intermolecular recognition site; other site 713604000681 dimerization interface [polypeptide binding]; other site 713604000682 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 713604000683 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 713604000684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604000685 Mg2+ binding site [ion binding]; other site 713604000686 G-X-G motif; other site 713604000687 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604000688 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604000689 Walker A/P-loop; other site 713604000690 ATP binding site [chemical binding]; other site 713604000691 Q-loop/lid; other site 713604000692 ABC transporter signature motif; other site 713604000693 Walker B; other site 713604000694 D-loop; other site 713604000695 H-loop/switch region; other site 713604000696 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604000697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604000698 dimer interface [polypeptide binding]; other site 713604000699 conserved gate region; other site 713604000700 putative PBP binding loops; other site 713604000701 ABC-ATPase subunit interface; other site 713604000702 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 713604000703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604000704 substrate binding pocket [chemical binding]; other site 713604000705 membrane-bound complex binding site; other site 713604000706 hinge residues; other site 713604000707 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 713604000708 polypeptide substrate binding site [polypeptide binding]; other site 713604000709 active site 713604000710 AAA ATPase domain; Region: AAA_16; pfam13191 713604000711 Predicted ATPase [General function prediction only]; Region: COG3899 713604000712 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604000713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604000714 DNA binding residues [nucleotide binding] 713604000715 dimerization interface [polypeptide binding]; other site 713604000716 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 713604000717 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 713604000718 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604000719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604000720 putative DNA binding site [nucleotide binding]; other site 713604000721 putative Zn2+ binding site [ion binding]; other site 713604000722 AsnC family; Region: AsnC_trans_reg; pfam01037 713604000723 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 713604000724 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 713604000725 dimer interface [polypeptide binding]; other site 713604000726 active site 713604000727 CoA binding pocket [chemical binding]; other site 713604000728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604000729 dimerization interface [polypeptide binding]; other site 713604000730 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 713604000731 cyclase homology domain; Region: CHD; cd07302 713604000732 nucleotidyl binding site; other site 713604000733 metal binding site [ion binding]; metal-binding site 713604000734 dimer interface [polypeptide binding]; other site 713604000735 Leucine carboxyl methyltransferase; Region: LCM; cl01306 713604000736 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604000737 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604000738 DNA-binding site [nucleotide binding]; DNA binding site 713604000739 FCD domain; Region: FCD; pfam07729 713604000740 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 713604000741 hypothetical protein; Provisional; Region: PRK10621 713604000742 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 713604000743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604000744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604000745 homodimer interface [polypeptide binding]; other site 713604000746 catalytic residue [active] 713604000747 Dienelactone hydrolase family; Region: DLH; pfam01738 713604000748 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 713604000749 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604000750 acyl-activating enzyme (AAE) consensus motif; other site 713604000751 AMP binding site [chemical binding]; other site 713604000752 active site 713604000753 CoA binding site [chemical binding]; other site 713604000754 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 713604000755 Cellulose binding domain; Region: CBM_2; pfam00553 713604000756 Glyco_18 domain; Region: Glyco_18; smart00636 713604000757 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 713604000758 active site 713604000759 Cellulose binding domain; Region: CBM_2; pfam00553 713604000760 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 713604000761 active site 713604000762 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 713604000763 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604000764 inhibitor-cofactor binding pocket; inhibition site 713604000765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604000766 catalytic residue [active] 713604000767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604000768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604000769 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604000770 putative dimerization interface [polypeptide binding]; other site 713604000771 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 713604000772 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 713604000773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604000774 binding surface 713604000775 TPR motif; other site 713604000776 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 713604000777 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604000778 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604000779 3D domain; Region: 3D; cl01439 713604000780 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 713604000781 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 713604000782 dimer interface [polypeptide binding]; other site 713604000783 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604000784 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604000785 active site 713604000786 catalytic tetrad [active] 713604000787 MarR family; Region: MarR_2; pfam12802 713604000788 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604000789 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604000790 ATP binding site [chemical binding]; other site 713604000791 Mg2+ binding site [ion binding]; other site 713604000792 G-X-G motif; other site 713604000793 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 713604000794 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000795 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604000796 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604000797 DNA binding residues [nucleotide binding] 713604000798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604000799 Transcription factor WhiB; Region: Whib; pfam02467 713604000800 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604000801 anti sigma factor interaction site; other site 713604000802 regulatory phosphorylation site [posttranslational modification]; other site 713604000803 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 713604000804 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604000805 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604000806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604000807 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604000808 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 713604000809 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604000810 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604000811 Walker A/P-loop; other site 713604000812 ATP binding site [chemical binding]; other site 713604000813 Q-loop/lid; other site 713604000814 ABC transporter signature motif; other site 713604000815 Walker B; other site 713604000816 D-loop; other site 713604000817 H-loop/switch region; other site 713604000818 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 713604000819 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604000820 dimerization interface [polypeptide binding]; other site 713604000821 putative Zn2+ binding site [ion binding]; other site 713604000822 putative DNA binding site [nucleotide binding]; other site 713604000823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604000824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604000825 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 713604000826 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604000827 NAD binding site [chemical binding]; other site 713604000828 substrate binding site [chemical binding]; other site 713604000829 putative active site [active] 713604000830 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 713604000831 active site 713604000832 catalytic triad [active] 713604000833 oxyanion hole [active] 713604000834 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604000835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000836 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604000837 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 713604000838 NodB motif; other site 713604000839 active site 713604000840 catalytic site [active] 713604000841 metal binding site [ion binding]; metal-binding site 713604000842 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 713604000843 putative hydrophobic ligand binding site [chemical binding]; other site 713604000844 protein interface [polypeptide binding]; other site 713604000845 gate; other site 713604000846 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 713604000847 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 713604000848 prephenate dehydrogenase; Validated; Region: PRK06545 713604000849 prephenate dehydrogenase; Validated; Region: PRK08507 713604000850 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 713604000851 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 713604000852 active site 713604000853 FMN binding site [chemical binding]; other site 713604000854 2,4-decadienoyl-CoA binding site; other site 713604000855 catalytic residue [active] 713604000856 4Fe-4S cluster binding site [ion binding]; other site 713604000857 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 713604000858 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604000859 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604000860 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 713604000861 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 713604000862 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 713604000863 active site 713604000864 nucleophile elbow; other site 713604000865 Leucine carboxyl methyltransferase; Region: LCM; cl01306 713604000866 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604000867 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604000868 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 713604000869 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604000870 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604000871 substrate binding pocket [chemical binding]; other site 713604000872 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604000873 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 713604000874 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 713604000875 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604000876 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604000877 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604000878 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604000879 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 713604000880 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 713604000881 tetramer interface [polypeptide binding]; other site 713604000882 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 713604000883 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604000884 DinB superfamily; Region: DinB_2; pfam12867 713604000885 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 713604000886 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604000887 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604000888 active site 713604000889 Cellulose synthase-like protein; Region: PLN02893 713604000890 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604000891 catalytic core [active] 713604000892 Alginate lyase; Region: Alginate_lyase; pfam05426 713604000893 potential frameshift: common BLAST hit: gi|300786621|ref|YP_003766912.1| transposase 713604000894 potential frameshift: common BLAST hit: gi|300786621|ref|YP_003766912.1| transposase 713604000895 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604000896 cleavage site 713604000897 active site 713604000898 substrate binding sites [chemical binding]; other site 713604000899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604000900 active site 713604000901 ATP binding site [chemical binding]; other site 713604000902 substrate binding site [chemical binding]; other site 713604000903 activation loop (A-loop); other site 713604000904 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 713604000905 active site 713604000906 zinc binding site [ion binding]; other site 713604000907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604000908 H-loop/switch region; other site 713604000909 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 713604000910 active site 713604000911 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 713604000912 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 713604000913 active site 713604000914 NAD binding site [chemical binding]; other site 713604000915 metal binding site [ion binding]; metal-binding site 713604000916 thiamine pyrophosphate protein; Validated; Region: PRK08199 713604000917 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604000918 PYR/PP interface [polypeptide binding]; other site 713604000919 dimer interface [polypeptide binding]; other site 713604000920 TPP binding site [chemical binding]; other site 713604000921 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604000922 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 713604000923 TPP-binding site [chemical binding]; other site 713604000924 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604000925 DNA-binding site [nucleotide binding]; DNA binding site 713604000926 RNA-binding motif; other site 713604000927 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604000928 metal-binding site [ion binding] 713604000929 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 713604000930 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 713604000931 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604000932 TPP-binding site [chemical binding]; other site 713604000933 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 713604000934 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604000935 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604000936 substrate binding pocket [chemical binding]; other site 713604000937 membrane-bound complex binding site; other site 713604000938 hinge residues; other site 713604000939 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604000940 active site 713604000941 ATP binding site [chemical binding]; other site 713604000942 substrate binding site [chemical binding]; other site 713604000943 activation loop (A-loop); other site 713604000944 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604000945 Int/Topo IB signature motif; other site 713604000946 DNA binding site [nucleotide binding] 713604000947 Helix-turn-helix domain; Region: HTH_17; cl17695 713604000948 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 713604000949 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 713604000950 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 713604000951 cofactor binding site; other site 713604000952 DNA binding site [nucleotide binding] 713604000953 substrate interaction site [chemical binding]; other site 713604000954 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 713604000955 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 713604000956 polymerase nucleotide-binding site; other site 713604000957 DNA-binding residues [nucleotide binding]; DNA binding site 713604000958 nucleotide binding site [chemical binding]; other site 713604000959 primase nucleotide-binding site [nucleotide binding]; other site 713604000960 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 713604000961 dimer interface [polypeptide binding]; other site 713604000962 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 713604000963 ssDNA binding site [nucleotide binding]; other site 713604000964 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604000965 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604000966 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 713604000967 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 713604000968 nudix motif; other site 713604000969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604000970 DNA-binding site [nucleotide binding]; DNA binding site 713604000971 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 713604000972 nudix motif; other site 713604000973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604000974 Zn2+ binding site [ion binding]; other site 713604000975 Mg2+ binding site [ion binding]; other site 713604000976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604000977 Coenzyme A binding pocket [chemical binding]; other site 713604000978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604000979 YCII-related domain; Region: YCII; cl00999 713604000980 N-acetyltransferase; Region: Acetyltransf_2; cl00949 713604000981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604000982 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 713604000983 putative active site [active] 713604000984 heme pocket [chemical binding]; other site 713604000985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604000986 putative active site [active] 713604000987 heme pocket [chemical binding]; other site 713604000988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604000989 putative active site [active] 713604000990 heme pocket [chemical binding]; other site 713604000991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604000992 metal binding site [ion binding]; metal-binding site 713604000993 active site 713604000994 I-site; other site 713604000995 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604000996 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604000997 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604000998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604000999 xanthine permease; Region: pbuX; TIGR03173 713604001000 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 713604001001 substrate binding site [chemical binding]; other site 713604001002 THF binding site; other site 713604001003 zinc-binding site [ion binding]; other site 713604001004 NIPSNAP; Region: NIPSNAP; pfam07978 713604001005 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604001006 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604001007 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604001008 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604001009 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604001010 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 713604001011 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604001012 Clp amino terminal domain; Region: Clp_N; pfam02861 713604001013 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604001014 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 713604001015 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 713604001016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604001017 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604001018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604001019 non-specific DNA binding site [nucleotide binding]; other site 713604001020 salt bridge; other site 713604001021 sequence-specific DNA binding site [nucleotide binding]; other site 713604001022 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604001023 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604001024 Methyltransferase domain; Region: Methyltransf_26; pfam13659 713604001025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001026 S-adenosylmethionine binding site [chemical binding]; other site 713604001027 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604001028 YtkA-like; Region: YtkA; pfam13115 713604001029 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604001030 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 713604001031 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604001032 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604001033 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 713604001034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604001035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604001036 amidase; Provisional; Region: PRK06061 713604001037 Amidase; Region: Amidase; cl11426 713604001038 RibD C-terminal domain; Region: RibD_C; cl17279 713604001039 D-cysteine desulfhydrase; Validated; Region: PRK03910 713604001040 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 713604001041 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604001042 catalytic residue [active] 713604001043 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 713604001044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 713604001045 Clp amino terminal domain; Region: Clp_N; pfam02861 713604001046 Clp amino terminal domain; Region: Clp_N; pfam02861 713604001047 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 713604001048 Predicted membrane protein [Function unknown]; Region: COG2364 713604001049 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604001050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604001051 DNA-binding site [nucleotide binding]; DNA binding site 713604001052 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604001053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001054 homodimer interface [polypeptide binding]; other site 713604001055 catalytic residue [active] 713604001056 aminotransferase; Validated; Region: PRK07777 713604001057 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604001058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001059 homodimer interface [polypeptide binding]; other site 713604001060 catalytic residue [active] 713604001061 Protein of unknown function (DUF445); Region: DUF445; pfam04286 713604001062 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604001063 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604001064 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604001065 active site 713604001066 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 713604001067 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 713604001068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604001069 Walker A/P-loop; other site 713604001070 ATP binding site [chemical binding]; other site 713604001071 Q-loop/lid; other site 713604001072 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 713604001073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001074 S-adenosylmethionine binding site [chemical binding]; other site 713604001075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604001076 non-specific DNA binding site [nucleotide binding]; other site 713604001077 salt bridge; other site 713604001078 sequence-specific DNA binding site [nucleotide binding]; other site 713604001079 CT11-RanBPM; Region: CRA; smart00757 713604001080 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 713604001081 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 713604001082 putative deacylase active site [active] 713604001083 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 713604001084 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 713604001085 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 713604001086 active sites [active] 713604001087 tetramer interface [polypeptide binding]; other site 713604001088 potential frameshift: common BLAST hit: gi|284034280|ref|YP_003384211.1| GCN5-related N-acetyltransferase 713604001089 Cadmium resistance transporter; Region: Cad; pfam03596 713604001090 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 713604001091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604001092 dimer interface [polypeptide binding]; other site 713604001093 conserved gate region; other site 713604001094 putative PBP binding loops; other site 713604001095 ABC-ATPase subunit interface; other site 713604001096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604001097 dimer interface [polypeptide binding]; other site 713604001098 conserved gate region; other site 713604001099 putative PBP binding loops; other site 713604001100 ABC-ATPase subunit interface; other site 713604001101 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 713604001102 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 713604001103 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604001104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001105 S-adenosylmethionine binding site [chemical binding]; other site 713604001106 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604001107 MarR family; Region: MarR; pfam01047 713604001108 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604001109 hydrophobic ligand binding site; other site 713604001110 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 713604001111 Prostaglandin dehydrogenases; Region: PGDH; cd05288 713604001112 NAD(P) binding site [chemical binding]; other site 713604001113 substrate binding site [chemical binding]; other site 713604001114 dimer interface [polypeptide binding]; other site 713604001115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604001116 motif II; other site 713604001117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604001118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604001119 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 713604001120 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 713604001121 putative NAD(P) binding site [chemical binding]; other site 713604001122 putative substrate binding site [chemical binding]; other site 713604001123 catalytic Zn binding site [ion binding]; other site 713604001124 structural Zn binding site [ion binding]; other site 713604001125 dimer interface [polypeptide binding]; other site 713604001126 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 713604001127 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 713604001128 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 713604001129 putative active site [active] 713604001130 putative substrate binding site [chemical binding]; other site 713604001131 putative cosubstrate binding site; other site 713604001132 catalytic site [active] 713604001133 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604001134 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604001135 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604001136 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 713604001137 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 713604001138 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 713604001139 FAD binding domain; Region: FAD_binding_4; pfam01565 713604001140 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 713604001141 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 713604001142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 713604001143 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 713604001144 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604001145 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604001146 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604001147 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 713604001148 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 713604001149 putative ADP-binding pocket [chemical binding]; other site 713604001150 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 713604001151 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 713604001152 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604001153 catalytic core [active] 713604001154 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 713604001155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604001156 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 713604001157 dimerization interface [polypeptide binding]; other site 713604001158 DNA binding residues [nucleotide binding] 713604001159 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604001160 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604001161 active site 713604001162 catalytic tetrad [active] 713604001163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604001164 dimer interface [polypeptide binding]; other site 713604001165 phosphorylation site [posttranslational modification] 713604001166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604001167 ATP binding site [chemical binding]; other site 713604001168 Mg2+ binding site [ion binding]; other site 713604001169 G-X-G motif; other site 713604001170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604001171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604001172 active site 713604001173 phosphorylation site [posttranslational modification] 713604001174 intermolecular recognition site; other site 713604001175 dimerization interface [polypeptide binding]; other site 713604001176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604001177 DNA binding site [nucleotide binding] 713604001178 exopolyphosphatase; Region: exo_poly_only; TIGR03706 713604001179 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 713604001180 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 713604001181 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604001182 DNA interaction; other site 713604001183 Metal-binding active site; metal-binding site 713604001184 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 713604001185 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604001186 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 713604001187 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 713604001188 DNA binding domain, excisionase family; Region: excise; TIGR01764 713604001189 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 713604001190 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604001191 putative NAD(P) binding site [chemical binding]; other site 713604001192 active site 713604001193 putative substrate binding site [chemical binding]; other site 713604001194 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604001195 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 713604001196 putative acyl-acceptor binding pocket; other site 713604001197 Putative sensor; Region: Sensor; pfam13796 713604001198 Histidine kinase; Region: HisKA_3; pfam07730 713604001199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604001200 ATP binding site [chemical binding]; other site 713604001201 Mg2+ binding site [ion binding]; other site 713604001202 G-X-G motif; other site 713604001203 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604001204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604001205 active site 713604001206 phosphorylation site [posttranslational modification] 713604001207 intermolecular recognition site; other site 713604001208 dimerization interface [polypeptide binding]; other site 713604001209 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 713604001210 DNA binding residues [nucleotide binding] 713604001211 CAAX protease self-immunity; Region: Abi; pfam02517 713604001212 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 713604001213 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 713604001214 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 713604001215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604001216 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604001217 DNA binding residues [nucleotide binding] 713604001218 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604001219 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604001220 acyl-activating enzyme (AAE) consensus motif; other site 713604001221 AMP binding site [chemical binding]; other site 713604001222 active site 713604001223 CoA binding site [chemical binding]; other site 713604001224 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 713604001225 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 713604001226 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 713604001227 Moco binding site; other site 713604001228 metal coordination site [ion binding]; other site 713604001229 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 713604001230 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 713604001231 CoA binding domain; Region: CoA_binding; smart00881 713604001232 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 713604001233 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 713604001234 tRNA; other site 713604001235 putative tRNA binding site [nucleotide binding]; other site 713604001236 putative NADP binding site [chemical binding]; other site 713604001237 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 713604001238 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 713604001239 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 713604001240 domain interfaces; other site 713604001241 active site 713604001242 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 713604001243 active site 713604001244 homodimer interface [polypeptide binding]; other site 713604001245 SAM binding site [chemical binding]; other site 713604001246 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 713604001247 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 713604001248 active site 713604001249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604001250 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604001251 NAD(P) binding site [chemical binding]; other site 713604001252 active site 713604001253 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604001254 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 713604001255 dimer interface [polypeptide binding]; other site 713604001256 active site 713604001257 Schiff base residues; other site 713604001258 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 713604001259 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 713604001260 HlyD family secretion protein; Region: HlyD_3; pfam13437 713604001261 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 713604001262 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604001263 Walker A/P-loop; other site 713604001264 ATP binding site [chemical binding]; other site 713604001265 Q-loop/lid; other site 713604001266 ABC transporter signature motif; other site 713604001267 Walker B; other site 713604001268 D-loop; other site 713604001269 H-loop/switch region; other site 713604001270 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 713604001271 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 713604001272 FtsX-like permease family; Region: FtsX; pfam02687 713604001273 TspO/MBR family; Region: TspO_MBR; pfam03073 713604001274 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 713604001275 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604001276 inhibitor-cofactor binding pocket; inhibition site 713604001277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001278 catalytic residue [active] 713604001279 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604001280 catalytic core [active] 713604001281 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 713604001282 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 713604001283 catalytic residues [active] 713604001284 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 713604001285 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 713604001286 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 713604001287 ResB-like family; Region: ResB; pfam05140 713604001288 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 713604001289 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 713604001290 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 713604001291 DNA binding residues [nucleotide binding] 713604001292 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604001293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604001294 putative DNA binding site [nucleotide binding]; other site 713604001295 putative Zn2+ binding site [ion binding]; other site 713604001296 AsnC family; Region: AsnC_trans_reg; pfam01037 713604001297 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 713604001298 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 713604001299 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604001300 catalytic residue [active] 713604001301 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 713604001302 UbiA prenyltransferase family; Region: UbiA; pfam01040 713604001303 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 713604001304 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604001305 acyl-activating enzyme (AAE) consensus motif; other site 713604001306 AMP binding site [chemical binding]; other site 713604001307 active site 713604001308 CoA binding site [chemical binding]; other site 713604001309 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604001310 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 713604001311 substrate binding site [chemical binding]; other site 713604001312 oxyanion hole (OAH) forming residues; other site 713604001313 trimer interface [polypeptide binding]; other site 713604001314 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 713604001315 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 713604001316 dimer interface [polypeptide binding]; other site 713604001317 tetramer interface [polypeptide binding]; other site 713604001318 PYR/PP interface [polypeptide binding]; other site 713604001319 TPP binding site [chemical binding]; other site 713604001320 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 713604001321 TPP-binding site; other site 713604001322 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 713604001323 Zn binding site [ion binding]; other site 713604001324 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 713604001325 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 713604001326 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 713604001327 active site 713604001328 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604001329 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 713604001330 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 713604001331 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 713604001332 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604001333 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 713604001334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001335 S-adenosylmethionine binding site [chemical binding]; other site 713604001336 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 713604001337 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 713604001338 NADH dehydrogenase subunit B; Validated; Region: PRK06411 713604001339 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 713604001340 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 713604001341 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 713604001342 NADH dehydrogenase subunit D; Validated; Region: PRK06075 713604001343 NADH dehydrogenase subunit E; Validated; Region: PRK07539 713604001344 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 713604001345 putative dimer interface [polypeptide binding]; other site 713604001346 [2Fe-2S] cluster binding site [ion binding]; other site 713604001347 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 713604001348 SLBB domain; Region: SLBB; pfam10531 713604001349 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 713604001350 NADH dehydrogenase subunit G; Validated; Region: PRK07860 713604001351 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604001352 catalytic loop [active] 713604001353 iron binding site [ion binding]; other site 713604001354 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 713604001355 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604001356 molybdopterin cofactor binding site; other site 713604001357 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 713604001358 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 713604001359 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 713604001360 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 713604001361 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 713604001362 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 713604001363 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 713604001364 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 713604001365 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 713604001366 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 713604001367 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 713604001368 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 713604001369 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 713604001370 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 713604001371 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 713604001372 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 713604001373 EspG family; Region: ESX-1_EspG; pfam14011 713604001374 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 713604001375 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 713604001376 substrate binding pocket [chemical binding]; other site 713604001377 chain length determination region; other site 713604001378 substrate-Mg2+ binding site; other site 713604001379 catalytic residues [active] 713604001380 aspartate-rich region 1; other site 713604001381 active site lid residues [active] 713604001382 aspartate-rich region 2; other site 713604001383 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604001384 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604001385 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 713604001386 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 713604001387 TPP-binding site [chemical binding]; other site 713604001388 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 713604001389 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 713604001390 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 713604001391 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 713604001392 dimer interface [polypeptide binding]; other site 713604001393 PYR/PP interface [polypeptide binding]; other site 713604001394 TPP binding site [chemical binding]; other site 713604001395 substrate binding site [chemical binding]; other site 713604001396 enoyl-CoA hydratase; Provisional; Region: PRK05870 713604001397 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604001398 substrate binding site [chemical binding]; other site 713604001399 oxyanion hole (OAH) forming residues; other site 713604001400 trimer interface [polypeptide binding]; other site 713604001401 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604001402 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604001403 AsnC family; Region: AsnC_trans_reg; pfam01037 713604001404 Amidinotransferase; Region: Amidinotransf; pfam02274 713604001405 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 713604001406 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 713604001407 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604001408 putative active site [active] 713604001409 putative metal binding site [ion binding]; other site 713604001410 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 713604001411 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 713604001412 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 713604001413 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 713604001414 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 713604001415 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 713604001416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604001417 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 713604001418 Chain length determinant protein; Region: Wzz; cl15801 713604001419 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 713604001420 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 713604001421 active site 713604001422 dimer interface [polypeptide binding]; other site 713604001423 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 713604001424 Ligand Binding Site [chemical binding]; other site 713604001425 Molecular Tunnel; other site 713604001426 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604001427 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 713604001428 putative NAD(P) binding site [chemical binding]; other site 713604001429 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604001430 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604001431 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 713604001432 Right handed beta helix region; Region: Beta_helix; pfam13229 713604001433 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604001434 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604001435 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 713604001436 active site 713604001437 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604001438 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604001439 Right handed beta helix region; Region: Beta_helix; pfam13229 713604001440 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 713604001441 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604001442 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604001443 catalytic residue [active] 713604001444 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 713604001445 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 713604001446 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 713604001447 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 713604001448 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 713604001449 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 713604001450 active site 713604001451 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 713604001452 M28 Zn-Peptidases; Region: M28_like_3; cd05644 713604001453 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 713604001454 active site 713604001455 metal binding site [ion binding]; metal-binding site 713604001456 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 713604001457 extended (e) SDRs; Region: SDR_e; cd08946 713604001458 NAD(P) binding site [chemical binding]; other site 713604001459 active site 713604001460 substrate binding site [chemical binding]; other site 713604001461 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 713604001462 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 713604001463 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604001464 active site 713604001465 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 713604001466 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604001467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604001468 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 713604001469 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604001470 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604001471 Uncharacterized conserved protein [Function unknown]; Region: COG3391 713604001472 heat shock protein HtpX; Provisional; Region: PRK03072 713604001473 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604001474 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 713604001475 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 713604001476 active site 713604001477 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 713604001478 non-prolyl cis peptide bond; other site 713604001479 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 713604001480 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 713604001481 substrate binding site; other site 713604001482 tetramer interface; other site 713604001483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 713604001484 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 713604001485 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604001486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001487 S-adenosylmethionine binding site [chemical binding]; other site 713604001488 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 713604001489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604001490 Walker A motif; other site 713604001491 ATP binding site [chemical binding]; other site 713604001492 Walker B motif; other site 713604001493 arginine finger; other site 713604001494 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 713604001495 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604001496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001497 S-adenosylmethionine binding site [chemical binding]; other site 713604001498 putative acetyltransferase; Provisional; Region: PRK03624 713604001499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604001500 Coenzyme A binding pocket [chemical binding]; other site 713604001501 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604001502 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604001503 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604001504 metal binding site [ion binding]; metal-binding site 713604001505 active site 713604001506 I-site; other site 713604001507 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604001508 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 713604001509 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 713604001510 active site 713604001511 catalytic site [active] 713604001512 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 713604001513 active site 713604001514 catalytic site [active] 713604001515 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 713604001516 active site 713604001517 catalytic triad [active] 713604001518 oxyanion hole [active] 713604001519 Predicted transcriptional regulators [Transcription]; Region: COG1725 713604001520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604001521 DNA-binding site [nucleotide binding]; DNA binding site 713604001522 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604001523 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604001524 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 713604001525 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 713604001526 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 713604001527 putative homodimer interface [polypeptide binding]; other site 713604001528 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 713604001529 heterodimer interface [polypeptide binding]; other site 713604001530 homodimer interface [polypeptide binding]; other site 713604001531 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 713604001532 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 713604001533 23S rRNA interface [nucleotide binding]; other site 713604001534 putative thiostrepton binding site; other site 713604001535 L7/L12 interface [polypeptide binding]; other site 713604001536 L25 interface [polypeptide binding]; other site 713604001537 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 713604001538 mRNA/rRNA interface [nucleotide binding]; other site 713604001539 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604001540 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604001541 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 713604001542 23S rRNA interface [nucleotide binding]; other site 713604001543 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 713604001544 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 713604001545 L11 interface [polypeptide binding]; other site 713604001546 putative EF-Tu interaction site [polypeptide binding]; other site 713604001547 putative EF-G interaction site [polypeptide binding]; other site 713604001548 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 713604001549 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 713604001550 Walker A/P-loop; other site 713604001551 ATP binding site [chemical binding]; other site 713604001552 Q-loop/lid; other site 713604001553 ABC transporter signature motif; other site 713604001554 Walker B; other site 713604001555 D-loop; other site 713604001556 H-loop/switch region; other site 713604001557 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604001558 Permease; Region: Permease; pfam02405 713604001559 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604001560 Permease; Region: Permease; pfam02405 713604001561 mce related protein; Region: MCE; pfam02470 713604001562 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604001563 mce related protein; Region: MCE; pfam02470 713604001564 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604001565 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604001566 mce related protein; Region: MCE; pfam02470 713604001567 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604001568 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 713604001569 linker region; other site 713604001570 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604001571 mce related protein; Region: MCE; pfam02470 713604001572 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604001573 mce related protein; Region: MCE; pfam02470 713604001574 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604001575 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604001576 mce related protein; Region: MCE; pfam02470 713604001577 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604001578 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604001579 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604001580 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604001581 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604001582 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001583 Cytochrome P450; Region: p450; cl12078 713604001584 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604001585 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604001586 acyl-activating enzyme (AAE) consensus motif; other site 713604001587 AMP binding site [chemical binding]; other site 713604001588 active site 713604001589 CoA binding site [chemical binding]; other site 713604001590 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001591 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001592 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001593 active site 713604001594 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001595 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001596 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001597 putative NADP binding site [chemical binding]; other site 713604001598 KR domain; Region: KR; pfam08659 713604001599 active site 713604001600 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001601 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001602 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001603 active site 713604001604 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001605 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001606 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001607 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 713604001608 active site 713604001609 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604001610 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001611 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 713604001612 KR domain; Region: KR; pfam08659 713604001613 NADP binding site [chemical binding]; other site 713604001614 active site 713604001615 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001616 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001617 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001618 active site 713604001619 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001620 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001621 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001622 putative NADP binding site [chemical binding]; other site 713604001623 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001624 active site 713604001625 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001626 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001627 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001628 active site 713604001629 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001630 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001631 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001632 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001633 putative NADP binding site [chemical binding]; other site 713604001634 active site 713604001635 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001636 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001637 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001638 active site 713604001639 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001640 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001641 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001642 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001643 putative NADP binding site [chemical binding]; other site 713604001644 active site 713604001645 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001646 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001647 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001648 active site 713604001649 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001650 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001651 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001652 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001653 putative NADP binding site [chemical binding]; other site 713604001654 active site 713604001655 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001656 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001657 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001658 active site 713604001659 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001660 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001661 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001662 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001663 putative NADP binding site [chemical binding]; other site 713604001664 active site 713604001665 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001666 Erythronolide synthase docking; Region: Docking; pfam08990 713604001667 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001668 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001669 active site 713604001670 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001671 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001672 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001673 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001674 putative NADP binding site [chemical binding]; other site 713604001675 active site 713604001676 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001677 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001678 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001679 active site 713604001680 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001681 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001682 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001683 putative NADP binding site [chemical binding]; other site 713604001684 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001685 active site 713604001686 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001687 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 713604001688 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 713604001689 dimer interface [polypeptide binding]; other site 713604001690 active site 713604001691 metal binding site [ion binding]; metal-binding site 713604001692 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 713604001693 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 713604001694 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 713604001695 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 713604001696 shikimate binding site; other site 713604001697 NAD(P) binding site [chemical binding]; other site 713604001698 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 713604001699 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 713604001700 inhibitor-cofactor binding pocket; inhibition site 713604001701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001702 catalytic residue [active] 713604001703 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604001704 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604001705 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604001706 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 713604001707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604001708 motif II; other site 713604001709 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604001710 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 713604001711 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604001712 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604001713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604001714 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604001715 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604001716 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604001717 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604001718 Cytochrome P450; Region: p450; cl12078 713604001719 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001720 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001721 Cytochrome P450; Region: p450; cl12078 713604001722 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 713604001723 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 713604001724 inhibitor-cofactor binding pocket; inhibition site 713604001725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001726 catalytic residue [active] 713604001727 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604001728 active site 713604001729 homodimer interface [polypeptide binding]; other site 713604001730 TDP-binding site; other site 713604001731 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 713604001732 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604001733 acetylornithine transaminase; Region: PLN00144 713604001734 inhibitor-cofactor binding pocket; inhibition site 713604001735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001736 catalytic residue [active] 713604001737 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604001738 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604001739 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604001740 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604001741 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604001742 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604001743 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604001744 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604001745 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 713604001746 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 713604001747 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 713604001748 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604001749 acyltransferase PapA5; Provisional; Region: PRK09294 713604001750 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604001751 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604001752 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001753 Cytochrome P450; Region: p450; cl12078 713604001754 tocopherol O-methyltransferase; Region: PLN02244 713604001755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001756 S-adenosylmethionine binding site [chemical binding]; other site 713604001757 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604001758 TPP-binding site [chemical binding]; other site 713604001759 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 713604001760 PYR/PP interface [polypeptide binding]; other site 713604001761 dimer interface [polypeptide binding]; other site 713604001762 TPP binding site [chemical binding]; other site 713604001763 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001764 Cytochrome P450; Region: p450; cl12078 713604001765 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 713604001766 Dehydroquinase class II; Region: DHquinase_II; pfam01220 713604001767 active site 713604001768 trimer interface [polypeptide binding]; other site 713604001769 dimer interface [polypeptide binding]; other site 713604001770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604001771 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604001772 DNA binding residues [nucleotide binding] 713604001773 dimerization interface [polypeptide binding]; other site 713604001774 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 713604001775 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 713604001776 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 713604001777 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 713604001778 RPB1 interaction site [polypeptide binding]; other site 713604001779 RPB10 interaction site [polypeptide binding]; other site 713604001780 RPB11 interaction site [polypeptide binding]; other site 713604001781 RPB3 interaction site [polypeptide binding]; other site 713604001782 RPB12 interaction site [polypeptide binding]; other site 713604001783 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 713604001784 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 713604001785 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 713604001786 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 713604001787 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 713604001788 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 713604001789 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 713604001790 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 713604001791 DNA binding site [nucleotide binding] 713604001792 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 713604001793 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 713604001794 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604001795 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604001796 putative DNA binding site [nucleotide binding]; other site 713604001797 putative Zn2+ binding site [ion binding]; other site 713604001798 AsnC family; Region: AsnC_trans_reg; pfam01037 713604001799 Double zinc ribbon; Region: DZR; pfam12773 713604001800 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604001801 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604001802 ligand binding site [chemical binding]; other site 713604001803 flexible hinge region; other site 713604001804 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 713604001805 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 713604001806 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 713604001807 S17 interaction site [polypeptide binding]; other site 713604001808 S8 interaction site; other site 713604001809 16S rRNA interaction site [nucleotide binding]; other site 713604001810 streptomycin interaction site [chemical binding]; other site 713604001811 23S rRNA interaction site [nucleotide binding]; other site 713604001812 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 713604001813 30S ribosomal protein S7; Validated; Region: PRK05302 713604001814 elongation factor G; Reviewed; Region: PRK00007 713604001815 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 713604001816 G1 box; other site 713604001817 putative GEF interaction site [polypeptide binding]; other site 713604001818 GTP/Mg2+ binding site [chemical binding]; other site 713604001819 Switch I region; other site 713604001820 G2 box; other site 713604001821 G3 box; other site 713604001822 Switch II region; other site 713604001823 G4 box; other site 713604001824 G5 box; other site 713604001825 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 713604001826 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 713604001827 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 713604001828 elongation factor Tu; Reviewed; Region: PRK00049 713604001829 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 713604001830 G1 box; other site 713604001831 GEF interaction site [polypeptide binding]; other site 713604001832 GTP/Mg2+ binding site [chemical binding]; other site 713604001833 Switch I region; other site 713604001834 G2 box; other site 713604001835 G3 box; other site 713604001836 Switch II region; other site 713604001837 G4 box; other site 713604001838 G5 box; other site 713604001839 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 713604001840 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 713604001841 Antibiotic Binding Site [chemical binding]; other site 713604001842 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 713604001843 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 713604001844 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 713604001845 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 713604001846 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 713604001847 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 713604001848 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 713604001849 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 713604001850 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 713604001851 putative translocon binding site; other site 713604001852 protein-rRNA interface [nucleotide binding]; other site 713604001853 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 713604001854 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 713604001855 G-X-X-G motif; other site 713604001856 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 713604001857 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 713604001858 23S rRNA interface [nucleotide binding]; other site 713604001859 5S rRNA interface [nucleotide binding]; other site 713604001860 putative antibiotic binding site [chemical binding]; other site 713604001861 L25 interface [polypeptide binding]; other site 713604001862 L27 interface [polypeptide binding]; other site 713604001863 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 713604001864 23S rRNA interface [nucleotide binding]; other site 713604001865 putative translocon interaction site; other site 713604001866 signal recognition particle (SRP54) interaction site; other site 713604001867 L23 interface [polypeptide binding]; other site 713604001868 trigger factor interaction site; other site 713604001869 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 713604001870 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 713604001871 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 713604001872 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 713604001873 RNA binding site [nucleotide binding]; other site 713604001874 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 713604001875 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 713604001876 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 713604001877 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 713604001878 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 713604001879 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 713604001880 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 713604001881 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 713604001882 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 713604001883 5S rRNA interface [nucleotide binding]; other site 713604001884 L27 interface [polypeptide binding]; other site 713604001885 23S rRNA interface [nucleotide binding]; other site 713604001886 L5 interface [polypeptide binding]; other site 713604001887 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 713604001888 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 713604001889 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 713604001890 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 713604001891 23S rRNA binding site [nucleotide binding]; other site 713604001892 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 713604001893 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604001894 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 713604001895 SecY translocase; Region: SecY; pfam00344 713604001896 adenylate kinase; Reviewed; Region: adk; PRK00279 713604001897 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 713604001898 AMP-binding site [chemical binding]; other site 713604001899 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 713604001900 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 713604001901 active site 713604001902 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 713604001903 rRNA binding site [nucleotide binding]; other site 713604001904 predicted 30S ribosome binding site; other site 713604001905 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 713604001906 30S ribosomal protein S13; Region: bact_S13; TIGR03631 713604001907 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 713604001908 30S ribosomal protein S11; Validated; Region: PRK05309 713604001909 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 713604001910 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 713604001911 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713604001912 RNA binding surface [nucleotide binding]; other site 713604001913 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 713604001914 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 713604001915 alphaNTD homodimer interface [polypeptide binding]; other site 713604001916 alphaNTD - beta interaction site [polypeptide binding]; other site 713604001917 alphaNTD - beta' interaction site [polypeptide binding]; other site 713604001918 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 713604001919 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 713604001920 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 713604001921 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 713604001922 active site 713604001923 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 713604001924 Protein of unknown function (DUF690); Region: DUF690; cl04939 713604001925 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 713604001926 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604001927 catalytic residues [active] 713604001928 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604001929 active site 713604001930 catalytic residues [active] 713604001931 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 713604001932 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 713604001933 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 713604001934 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604001935 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 713604001936 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604001937 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 713604001938 nucleotide binding site [chemical binding]; other site 713604001939 putative NEF/HSP70 interaction site [polypeptide binding]; other site 713604001940 SBD interface [polypeptide binding]; other site 713604001941 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 713604001942 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 713604001943 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 713604001944 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 713604001945 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 713604001946 23S rRNA interface [nucleotide binding]; other site 713604001947 L3 interface [polypeptide binding]; other site 713604001948 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 713604001949 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 713604001950 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 713604001951 active site 713604001952 substrate binding site [chemical binding]; other site 713604001953 metal binding site [ion binding]; metal-binding site 713604001954 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001955 acyl-CoA synthetase; Validated; Region: PRK05850 713604001956 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604001957 acyl-activating enzyme (AAE) consensus motif; other site 713604001958 active site 713604001959 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604001960 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604001961 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 713604001962 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 713604001963 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 713604001964 glutaminase active site [active] 713604001965 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 713604001966 dimer interface [polypeptide binding]; other site 713604001967 active site 713604001968 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 713604001969 dimer interface [polypeptide binding]; other site 713604001970 active site 713604001971 Uncharacterized conserved protein [Function unknown]; Region: COG0062 713604001972 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 713604001973 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604001974 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604001975 glycerol kinase; Region: PLN02295 713604001976 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604001977 nucleotide binding site [chemical binding]; other site 713604001978 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 713604001979 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 713604001980 Walker A/P-loop; other site 713604001981 ATP binding site [chemical binding]; other site 713604001982 Q-loop/lid; other site 713604001983 ABC transporter signature motif; other site 713604001984 Walker B; other site 713604001985 D-loop; other site 713604001986 H-loop/switch region; other site 713604001987 TOBE domain; Region: TOBE_2; pfam08402 713604001988 alanine racemase; Reviewed; Region: alr; PRK00053 713604001989 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 713604001990 active site 713604001991 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604001992 dimer interface [polypeptide binding]; other site 713604001993 substrate binding site [chemical binding]; other site 713604001994 catalytic residues [active] 713604001995 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604001996 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604001997 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 713604001998 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 713604001999 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 713604002000 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 713604002001 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604002002 acyl-CoA synthetase; Validated; Region: PRK07787 713604002003 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604002004 acyl-activating enzyme (AAE) consensus motif; other site 713604002005 AMP binding site [chemical binding]; other site 713604002006 active site 713604002007 CoA binding site [chemical binding]; other site 713604002008 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 713604002009 Glycoprotease family; Region: Peptidase_M22; pfam00814 713604002010 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 713604002011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604002012 Coenzyme A binding pocket [chemical binding]; other site 713604002013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604002014 UGMP family protein; Validated; Region: PRK09604 713604002015 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 713604002016 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 713604002017 active site 713604002018 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 713604002019 homodimer interface [polypeptide binding]; other site 713604002020 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 713604002021 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604002022 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604002023 active site 713604002024 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 713604002025 amidase catalytic site [active] 713604002026 Zn binding residues [ion binding]; other site 713604002027 substrate binding site [chemical binding]; other site 713604002028 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604002029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604002030 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604002031 dimerization interface [polypeptide binding]; other site 713604002032 putative DNA binding site [nucleotide binding]; other site 713604002033 putative Zn2+ binding site [ion binding]; other site 713604002034 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 713604002035 Low molecular weight phosphatase family; Region: LMWPc; cd00115 713604002036 active site 713604002037 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 713604002038 arsenical-resistance protein; Region: acr3; TIGR00832 713604002039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604002040 dimerization interface [polypeptide binding]; other site 713604002041 putative DNA binding site [nucleotide binding]; other site 713604002042 putative Zn2+ binding site [ion binding]; other site 713604002043 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604002044 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604002045 active site 713604002046 metal binding site [ion binding]; metal-binding site 713604002047 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 713604002048 oligomerisation interface [polypeptide binding]; other site 713604002049 mobile loop; other site 713604002050 roof hairpin; other site 713604002051 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 713604002052 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 713604002053 ring oligomerisation interface [polypeptide binding]; other site 713604002054 ATP/Mg binding site [chemical binding]; other site 713604002055 stacking interactions; other site 713604002056 hinge regions; other site 713604002057 Transcription factor WhiB; Region: Whib; pfam02467 713604002058 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 713604002059 DNA binding residues [nucleotide binding] 713604002060 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604002061 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002063 active site 713604002064 phosphorylation site [posttranslational modification] 713604002065 intermolecular recognition site; other site 713604002066 dimerization interface [polypeptide binding]; other site 713604002067 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002068 DNA binding residues [nucleotide binding] 713604002069 dimerization interface [polypeptide binding]; other site 713604002070 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 713604002071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604002072 DNA binding residues [nucleotide binding] 713604002073 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 713604002074 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604002075 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 713604002076 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 713604002077 active site 713604002078 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 713604002079 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604002080 phosphate binding site [ion binding]; other site 713604002081 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604002082 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 713604002083 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604002084 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 713604002085 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604002086 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604002087 FAD binding domain; Region: FAD_binding_4; pfam01565 713604002088 Berberine and berberine like; Region: BBE; pfam08031 713604002089 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604002090 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 713604002091 NAD(P) binding site [chemical binding]; other site 713604002092 catalytic residues [active] 713604002093 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 713604002094 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604002095 catalytic Zn binding site [ion binding]; other site 713604002096 NAD(P) binding site [chemical binding]; other site 713604002097 structural Zn binding site [ion binding]; other site 713604002098 Rhomboid family; Region: Rhomboid; cl11446 713604002099 DinB superfamily; Region: DinB_2; pfam12867 713604002100 GMP synthase; Reviewed; Region: guaA; PRK00074 713604002101 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 713604002102 AMP/PPi binding site [chemical binding]; other site 713604002103 candidate oxyanion hole; other site 713604002104 catalytic triad [active] 713604002105 potential glutamine specificity residues [chemical binding]; other site 713604002106 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 713604002107 ATP Binding subdomain [chemical binding]; other site 713604002108 Ligand Binding sites [chemical binding]; other site 713604002109 Dimerization subdomain; other site 713604002110 PspC domain; Region: PspC; pfam04024 713604002111 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 713604002112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604002113 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 713604002114 PspC domain; Region: PspC; pfam04024 713604002115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604002116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604002117 ATP binding site [chemical binding]; other site 713604002118 Mg2+ binding site [ion binding]; other site 713604002119 G-X-G motif; other site 713604002120 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002122 active site 713604002123 phosphorylation site [posttranslational modification] 713604002124 intermolecular recognition site; other site 713604002125 dimerization interface [polypeptide binding]; other site 713604002126 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002127 DNA binding residues [nucleotide binding] 713604002128 dimerization interface [polypeptide binding]; other site 713604002129 EamA-like transporter family; Region: EamA; pfam00892 713604002130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604002131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604002132 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604002133 putative dimerization interface [polypeptide binding]; other site 713604002134 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604002135 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604002136 active site 713604002137 ATP binding site [chemical binding]; other site 713604002138 substrate binding site [chemical binding]; other site 713604002139 activation loop (A-loop); other site 713604002140 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604002141 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604002142 active site 713604002143 ATP binding site [chemical binding]; other site 713604002144 substrate binding site [chemical binding]; other site 713604002145 activation loop (A-loop); other site 713604002146 Chorismate mutase type II; Region: CM_2; cl00693 713604002147 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604002148 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 713604002149 Part of AAA domain; Region: AAA_19; pfam13245 713604002150 Family description; Region: UvrD_C_2; pfam13538 713604002151 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 713604002152 Peptidase family M23; Region: Peptidase_M23; pfam01551 713604002153 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 713604002154 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 713604002155 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 713604002156 CoA-ligase; Region: Ligase_CoA; pfam00549 713604002157 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 713604002158 CoA binding domain; Region: CoA_binding; smart00881 713604002159 CoA-ligase; Region: Ligase_CoA; pfam00549 713604002160 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 713604002161 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 713604002162 active site 713604002163 substrate binding site [chemical binding]; other site 713604002164 cosubstrate binding site; other site 713604002165 catalytic site [active] 713604002166 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 713604002167 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 713604002168 purine monophosphate binding site [chemical binding]; other site 713604002169 dimer interface [polypeptide binding]; other site 713604002170 putative catalytic residues [active] 713604002171 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 713604002172 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 713604002173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604002174 Coenzyme A binding pocket [chemical binding]; other site 713604002175 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 713604002176 Zn2+ binding site [ion binding]; other site 713604002177 Mg2+ binding site [ion binding]; other site 713604002178 Y-family of DNA polymerases; Region: PolY; cl12025 713604002179 DNA binding site [nucleotide binding] 713604002180 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 713604002181 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 713604002182 active site 713604002183 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 713604002184 generic binding surface II; other site 713604002185 generic binding surface I; other site 713604002186 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 713604002187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604002188 S-adenosylmethionine binding site [chemical binding]; other site 713604002189 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 713604002190 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 713604002191 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 713604002192 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 713604002193 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 713604002194 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 713604002195 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 713604002196 homodimer interface [polypeptide binding]; other site 713604002197 NADP binding site [chemical binding]; other site 713604002198 substrate binding site [chemical binding]; other site 713604002199 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 713604002200 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604002201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002202 putative substrate translocation pore; other site 713604002203 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604002204 dimerization interface [polypeptide binding]; other site 713604002205 putative DNA binding site [nucleotide binding]; other site 713604002206 putative Zn2+ binding site [ion binding]; other site 713604002207 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604002208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002209 putative substrate translocation pore; other site 713604002210 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 713604002211 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 713604002212 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 713604002213 minor groove reading motif; other site 713604002214 helix-hairpin-helix signature motif; other site 713604002215 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 713604002216 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604002217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604002218 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 713604002219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604002220 S-adenosylmethionine binding site [chemical binding]; other site 713604002221 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 713604002222 isocitrate dehydrogenase; Validated; Region: PRK08299 713604002223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002225 WHG domain; Region: WHG; pfam13305 713604002226 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 713604002227 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 713604002228 putative active site [active] 713604002229 putative catalytic site [active] 713604002230 putative DNA binding site [nucleotide binding]; other site 713604002231 putative phosphate binding site [ion binding]; other site 713604002232 metal binding site A [ion binding]; metal-binding site 713604002233 putative AP binding site [nucleotide binding]; other site 713604002234 putative metal binding site B [ion binding]; other site 713604002235 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 713604002236 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 713604002237 active site 713604002238 HIGH motif; other site 713604002239 dimer interface [polypeptide binding]; other site 713604002240 KMSKS motif; other site 713604002241 AAA domain; Region: AAA_33; pfam13671 713604002242 AAA domain; Region: AAA_17; pfam13207 713604002243 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 713604002244 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604002245 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604002246 active site 713604002247 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604002248 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604002249 dimerization interface [polypeptide binding]; other site 713604002250 putative DNA binding site [nucleotide binding]; other site 713604002251 putative Zn2+ binding site [ion binding]; other site 713604002252 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 713604002253 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 713604002254 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604002255 active site 713604002256 catalytic residues [active] 713604002257 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 713604002258 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 713604002259 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 713604002260 L-aspartate oxidase; Provisional; Region: PRK06175 713604002261 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 713604002262 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 713604002263 putative Iron-sulfur protein interface [polypeptide binding]; other site 713604002264 putative proximal heme binding site [chemical binding]; other site 713604002265 putative SdhC-like subunit interface [polypeptide binding]; other site 713604002266 putative distal heme binding site [chemical binding]; other site 713604002267 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 713604002268 putative Iron-sulfur protein interface [polypeptide binding]; other site 713604002269 putative proximal heme binding site [chemical binding]; other site 713604002270 putative SdhD-like interface [polypeptide binding]; other site 713604002271 putative distal heme binding site [chemical binding]; other site 713604002272 alpha-galactosidase; Region: PLN02808; cl17638 713604002273 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 713604002274 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 713604002275 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 713604002276 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 713604002277 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 713604002278 ligand binding site [chemical binding]; other site 713604002279 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 713604002280 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604002281 Walker A/P-loop; other site 713604002282 ATP binding site [chemical binding]; other site 713604002283 Q-loop/lid; other site 713604002284 ABC transporter signature motif; other site 713604002285 Walker B; other site 713604002286 D-loop; other site 713604002287 H-loop/switch region; other site 713604002288 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604002289 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604002290 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 713604002291 TM-ABC transporter signature motif; other site 713604002292 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604002293 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 713604002294 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 713604002295 TM-ABC transporter signature motif; other site 713604002296 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 713604002297 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 713604002298 active site 713604002299 catalytic motif [active] 713604002300 Zn binding site [ion binding]; other site 713604002301 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 713604002302 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 713604002303 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 713604002304 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 713604002305 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 713604002306 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 713604002307 adenosine deaminase; Provisional; Region: PRK09358 713604002308 active site 713604002309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002310 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604002311 putative substrate translocation pore; other site 713604002312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604002313 ATP binding site [chemical binding]; other site 713604002314 putative Mg++ binding site [ion binding]; other site 713604002315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604002316 nucleotide binding region [chemical binding]; other site 713604002317 ATP-binding site [chemical binding]; other site 713604002318 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 713604002319 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 713604002320 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604002321 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604002322 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 713604002323 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 713604002324 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604002325 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 713604002326 putative NAD(P) binding site [chemical binding]; other site 713604002327 catalytic Zn binding site [ion binding]; other site 713604002328 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604002329 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604002330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604002331 dimer interface [polypeptide binding]; other site 713604002332 conserved gate region; other site 713604002333 putative PBP binding loops; other site 713604002334 ABC-ATPase subunit interface; other site 713604002335 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604002336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604002337 dimer interface [polypeptide binding]; other site 713604002338 conserved gate region; other site 713604002339 putative PBP binding loops; other site 713604002340 ABC-ATPase subunit interface; other site 713604002341 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 713604002342 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604002343 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604002344 Cytochrome P450; Region: p450; cl12078 713604002345 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604002346 Cytochrome P450; Region: p450; cl12078 713604002347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002349 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 713604002350 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604002351 NAD(P) binding site [chemical binding]; other site 713604002352 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 713604002353 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604002354 NAD(P) binding site [chemical binding]; other site 713604002355 catalytic residues [active] 713604002356 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 713604002357 intersubunit interface [polypeptide binding]; other site 713604002358 active site 713604002359 catalytic residue [active] 713604002360 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604002361 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 713604002362 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 713604002363 active site 713604002364 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604002365 active site 713604002366 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 713604002367 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604002368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604002369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002371 WHG domain; Region: WHG; pfam13305 713604002372 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604002373 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 713604002374 DNA binding residues [nucleotide binding] 713604002375 putative dimer interface [polypeptide binding]; other site 713604002376 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604002377 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604002378 active site 713604002379 catalytic tetrad [active] 713604002380 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604002381 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 713604002382 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 713604002383 active site 713604002384 substrate binding site [chemical binding]; other site 713604002385 FMN binding site [chemical binding]; other site 713604002386 putative catalytic residues [active] 713604002387 Cytochrome P450; Region: p450; cl12078 713604002388 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 713604002389 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604002390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002391 active site 713604002392 phosphorylation site [posttranslational modification] 713604002393 intermolecular recognition site; other site 713604002394 dimerization interface [polypeptide binding]; other site 713604002395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604002396 DNA binding site [nucleotide binding] 713604002397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604002398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604002399 dimer interface [polypeptide binding]; other site 713604002400 phosphorylation site [posttranslational modification] 713604002401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604002402 ATP binding site [chemical binding]; other site 713604002403 Mg2+ binding site [ion binding]; other site 713604002404 G-X-G motif; other site 713604002405 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 713604002406 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 713604002407 dimer interface [polypeptide binding]; other site 713604002408 motif 1; other site 713604002409 active site 713604002410 motif 2; other site 713604002411 motif 3; other site 713604002412 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 713604002413 anticodon binding site; other site 713604002414 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604002415 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604002416 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604002417 active site 713604002418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604002419 non-specific DNA binding site [nucleotide binding]; other site 713604002420 salt bridge; other site 713604002421 sequence-specific DNA binding site [nucleotide binding]; other site 713604002422 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 713604002423 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604002424 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 713604002425 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 713604002426 active site 713604002427 substrate binding site [chemical binding]; other site 713604002428 metal binding site [ion binding]; metal-binding site 713604002429 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604002430 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604002431 homodimer interface [polypeptide binding]; other site 713604002432 active site 713604002433 TDP-binding site; other site 713604002434 acceptor substrate-binding pocket; other site 713604002435 purine nucleoside phosphorylase; Provisional; Region: PRK08202 713604002436 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 713604002437 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604002438 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604002439 DNA binding residues [nucleotide binding] 713604002440 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604002441 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604002442 active site 713604002443 ATP binding site [chemical binding]; other site 713604002444 substrate binding site [chemical binding]; other site 713604002445 activation loop (A-loop); other site 713604002446 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 713604002447 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 713604002448 heterodimer interface [polypeptide binding]; other site 713604002449 substrate interaction site [chemical binding]; other site 713604002450 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 713604002451 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 713604002452 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 713604002453 active site 713604002454 substrate binding site [chemical binding]; other site 713604002455 coenzyme B12 binding site [chemical binding]; other site 713604002456 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 713604002457 B12 binding site [chemical binding]; other site 713604002458 cobalt ligand [ion binding]; other site 713604002459 membrane ATPase/protein kinase; Provisional; Region: PRK09435 713604002460 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 713604002461 Walker A; other site 713604002462 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 713604002463 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 713604002464 metal binding site [ion binding]; metal-binding site 713604002465 putative dimer interface [polypeptide binding]; other site 713604002466 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 713604002467 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 713604002468 putative active site [active] 713604002469 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 713604002470 dimerization interface [polypeptide binding]; other site 713604002471 putative active site pocket [active] 713604002472 putative catalytic residue [active] 713604002473 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 713604002474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604002475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604002476 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604002477 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604002478 active site 713604002479 putative catalytic site [active] 713604002480 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604002481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604002482 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604002483 glycerol kinase; Provisional; Region: glpK; PRK00047 713604002484 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 713604002485 N- and C-terminal domain interface [polypeptide binding]; other site 713604002486 active site 713604002487 MgATP binding site [chemical binding]; other site 713604002488 catalytic site [active] 713604002489 metal binding site [ion binding]; metal-binding site 713604002490 putative homotetramer interface [polypeptide binding]; other site 713604002491 glycerol binding site [chemical binding]; other site 713604002492 homodimer interface [polypeptide binding]; other site 713604002493 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 713604002494 amphipathic channel; other site 713604002495 Asn-Pro-Ala signature motifs; other site 713604002496 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 713604002497 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604002498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002499 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 713604002500 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 713604002501 putative NAD(P) binding site [chemical binding]; other site 713604002502 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604002503 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604002504 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604002505 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 713604002506 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604002507 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 713604002508 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 713604002509 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604002510 carboxyltransferase (CT) interaction site; other site 713604002511 biotinylation site [posttranslational modification]; other site 713604002512 2,4-diaminobutyrate 4-transaminases; Region: dat; TIGR00709 713604002513 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 713604002514 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 713604002515 Maf-like protein; Region: Maf; pfam02545 713604002516 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 713604002517 active site 713604002518 dimer interface [polypeptide binding]; other site 713604002519 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604002520 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604002521 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604002522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604002523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002524 putative substrate translocation pore; other site 713604002525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002526 putative substrate translocation pore; other site 713604002527 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604002528 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604002529 TROVE domain; Region: TROVE; pfam05731 713604002530 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604002531 metal ion-dependent adhesion site (MIDAS); other site 713604002532 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604002533 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604002534 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604002535 MarR family; Region: MarR_2; pfam12802 713604002536 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 713604002537 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 713604002538 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 713604002539 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604002540 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 713604002541 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002543 active site 713604002544 phosphorylation site [posttranslational modification] 713604002545 intermolecular recognition site; other site 713604002546 dimerization interface [polypeptide binding]; other site 713604002547 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002548 DNA binding residues [nucleotide binding] 713604002549 dimerization interface [polypeptide binding]; other site 713604002550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604002551 Histidine kinase; Region: HisKA_3; pfam07730 713604002552 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604002553 Mg2+ binding site [ion binding]; other site 713604002554 G-X-G motif; other site 713604002555 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 713604002556 putative hydrophobic ligand binding site [chemical binding]; other site 713604002557 MarR family; Region: MarR_2; pfam12802 713604002558 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 713604002559 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604002560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002562 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604002563 hypothetical protein; Provisional; Region: PRK07588 713604002564 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604002565 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604002566 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 713604002567 short chain dehydrogenase; Provisional; Region: PRK06500 713604002568 classical (c) SDRs; Region: SDR_c; cd05233 713604002569 NAD(P) binding site [chemical binding]; other site 713604002570 active site 713604002571 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604002572 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604002573 conserved cys residue [active] 713604002574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604002575 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 713604002576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604002577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604002578 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604002579 dimerization interface [polypeptide binding]; other site 713604002580 substrate binding pocket [chemical binding]; other site 713604002581 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604002582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002584 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604002585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604002586 S-adenosylmethionine binding site [chemical binding]; other site 713604002587 RibD C-terminal domain; Region: RibD_C; cl17279 713604002588 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604002589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604002590 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 713604002591 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 713604002592 FMN binding site [chemical binding]; other site 713604002593 active site 713604002594 substrate binding site [chemical binding]; other site 713604002595 catalytic residue [active] 713604002596 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604002597 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604002598 active site 713604002599 metal binding site [ion binding]; metal-binding site 713604002600 Histidine kinase; Region: HisKA_3; pfam07730 713604002601 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604002602 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002604 active site 713604002605 phosphorylation site [posttranslational modification] 713604002606 intermolecular recognition site; other site 713604002607 dimerization interface [polypeptide binding]; other site 713604002608 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002609 DNA binding residues [nucleotide binding] 713604002610 dimerization interface [polypeptide binding]; other site 713604002611 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604002612 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604002613 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 713604002614 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 713604002615 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 713604002616 Bacterial PH domain; Region: DUF304; pfam03703 713604002617 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 713604002618 active site 713604002619 catalytic residues [active] 713604002620 metal binding site [ion binding]; metal-binding site 713604002621 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 713604002622 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604002623 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604002624 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 713604002625 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 713604002626 active site 713604002627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604002628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002629 active site 713604002630 phosphorylation site [posttranslational modification] 713604002631 intermolecular recognition site; other site 713604002632 dimerization interface [polypeptide binding]; other site 713604002633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604002634 DNA binding site [nucleotide binding] 713604002635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604002636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604002637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604002638 ATP binding site [chemical binding]; other site 713604002639 Mg2+ binding site [ion binding]; other site 713604002640 G-X-G motif; other site 713604002641 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002642 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002643 DNA binding residues [nucleotide binding] 713604002644 dimerization interface [polypeptide binding]; other site 713604002645 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002647 active site 713604002648 phosphorylation site [posttranslational modification] 713604002649 intermolecular recognition site; other site 713604002650 dimerization interface [polypeptide binding]; other site 713604002651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002652 DNA binding residues [nucleotide binding] 713604002653 dimerization interface [polypeptide binding]; other site 713604002654 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604002655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604002656 NAD(P) binding site [chemical binding]; other site 713604002657 active site 713604002658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002659 putative substrate translocation pore; other site 713604002660 Predicted membrane protein [Function unknown]; Region: COG2246 713604002661 GtrA-like protein; Region: GtrA; pfam04138 713604002662 GtrA-like protein; Region: GtrA; pfam04138 713604002663 Predicted membrane protein [Function unknown]; Region: COG2246 713604002664 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604002665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604002666 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604002667 DNA binding residues [nucleotide binding] 713604002668 Putative zinc-finger; Region: zf-HC2; pfam13490 713604002669 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 713604002670 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 713604002671 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 713604002672 ATP-grasp domain; Region: ATP-grasp; pfam02222 713604002673 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 713604002674 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604002675 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604002676 acyl-activating enzyme (AAE) consensus motif; other site 713604002677 AMP binding site [chemical binding]; other site 713604002678 active site 713604002679 CoA binding site [chemical binding]; other site 713604002680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604002681 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604002682 active site 713604002683 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 713604002684 Lipase (class 2); Region: Lipase_2; pfam01674 713604002685 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604002686 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 713604002687 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 713604002688 Predicted membrane protein [Function unknown]; Region: COG2259 713604002689 TIGR03089 family protein; Region: TIGR03089 713604002690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604002691 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604002692 NAD(P) binding site [chemical binding]; other site 713604002693 active site 713604002694 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604002695 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604002696 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 713604002697 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 713604002698 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 713604002699 NAD binding site [chemical binding]; other site 713604002700 substrate binding site [chemical binding]; other site 713604002701 homodimer interface [polypeptide binding]; other site 713604002702 active site 713604002703 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 713604002704 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 713604002705 NADP binding site [chemical binding]; other site 713604002706 active site 713604002707 putative substrate binding site [chemical binding]; other site 713604002708 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 713604002709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604002710 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604002711 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 713604002712 Probable Catalytic site; other site 713604002713 metal-binding site 713604002714 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604002715 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604002716 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604002717 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 713604002718 Probable Catalytic site; other site 713604002719 metal-binding site 713604002720 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 713604002721 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604002722 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604002723 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 713604002724 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 713604002725 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604002726 Probable Catalytic site; other site 713604002727 metal-binding site 713604002728 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 713604002729 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 713604002730 active site 713604002731 Substrate binding site; other site 713604002732 Mg++ binding site; other site 713604002733 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604002734 putative CoA binding site [chemical binding]; other site 713604002735 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 713604002736 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 713604002737 minor groove reading motif; other site 713604002738 helix-hairpin-helix signature motif; other site 713604002739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604002740 DNA-binding site [nucleotide binding]; DNA binding site 713604002741 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 713604002742 nudix motif; other site 713604002743 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 713604002744 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 713604002745 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 713604002746 putative FMN binding site [chemical binding]; other site 713604002747 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 713604002748 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 713604002749 dimer interface [polypeptide binding]; other site 713604002750 phosphate binding site [ion binding]; other site 713604002751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604002752 Coenzyme A binding pocket [chemical binding]; other site 713604002753 Ferredoxin [Energy production and conversion]; Region: COG1146 713604002754 4Fe-4S binding domain; Region: Fer4; pfam00037 713604002755 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 713604002756 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604002757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604002758 homodimer interface [polypeptide binding]; other site 713604002759 catalytic residue [active] 713604002760 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002761 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002762 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604002763 hypothetical protein; Provisional; Region: PRK06184 713604002764 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604002765 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 713604002766 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 713604002767 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604002768 putative trimer interface [polypeptide binding]; other site 713604002769 putative CoA binding site [chemical binding]; other site 713604002770 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 713604002771 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 713604002772 metal binding site [ion binding]; metal-binding site 713604002773 putative dimer interface [polypeptide binding]; other site 713604002774 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 713604002775 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 713604002776 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 713604002777 putative active site [active] 713604002778 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 713604002779 Peptidase family M28; Region: Peptidase_M28; pfam04389 713604002780 active site 713604002781 metal binding site [ion binding]; metal-binding site 713604002782 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 713604002783 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 713604002784 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 713604002785 active site 713604002786 Zn binding site [ion binding]; other site 713604002787 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 713604002788 Helix-turn-helix domain; Region: HTH_19; pfam12844 713604002789 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 713604002790 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 713604002791 active site 713604002792 Zn binding site [ion binding]; other site 713604002793 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 713604002794 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604002795 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604002796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604002797 non-specific DNA binding site [nucleotide binding]; other site 713604002798 salt bridge; other site 713604002799 sequence-specific DNA binding site [nucleotide binding]; other site 713604002800 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604002801 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 713604002802 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 713604002803 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604002804 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604002805 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604002806 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 713604002807 Probable Catalytic site; other site 713604002808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002809 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 713604002810 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 713604002811 Methyltransferase domain; Region: Methyltransf_24; pfam13578 713604002812 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604002813 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604002814 putative acyl-acceptor binding pocket; other site 713604002815 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 713604002816 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 713604002817 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 713604002818 Walker A/P-loop; other site 713604002819 ATP binding site [chemical binding]; other site 713604002820 Q-loop/lid; other site 713604002821 ABC transporter signature motif; other site 713604002822 Walker B; other site 713604002823 D-loop; other site 713604002824 H-loop/switch region; other site 713604002825 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 713604002826 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 713604002827 Walker A/P-loop; other site 713604002828 ATP binding site [chemical binding]; other site 713604002829 Q-loop/lid; other site 713604002830 ABC transporter signature motif; other site 713604002831 Walker B; other site 713604002832 D-loop; other site 713604002833 H-loop/switch region; other site 713604002834 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 713604002835 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 713604002836 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 713604002837 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 713604002838 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604002839 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604002840 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604002841 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604002842 hydrophobic ligand binding site; other site 713604002843 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 713604002844 enoyl-CoA hydratase; Provisional; Region: PRK08140 713604002845 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604002846 substrate binding site [chemical binding]; other site 713604002847 oxyanion hole (OAH) forming residues; other site 713604002848 trimer interface [polypeptide binding]; other site 713604002849 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 713604002850 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 713604002851 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 713604002852 interface (dimer of trimers) [polypeptide binding]; other site 713604002853 Substrate-binding/catalytic site; other site 713604002854 Zn-binding sites [ion binding]; other site 713604002855 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 713604002856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604002857 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 713604002858 putative dimerization interface [polypeptide binding]; other site 713604002859 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604002860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002861 putative substrate translocation pore; other site 713604002862 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 713604002863 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604002864 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 713604002865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604002866 S-adenosylmethionine binding site [chemical binding]; other site 713604002867 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 713604002868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604002869 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604002870 DNA binding residues [nucleotide binding] 713604002871 Putative zinc-finger; Region: zf-HC2; pfam13490 713604002872 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604002873 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604002874 sec-independent translocase; Provisional; Region: PRK03100 713604002875 Domain of unknown function DUF59; Region: DUF59; cl00941 713604002876 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 713604002877 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 713604002878 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604002879 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 713604002880 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 713604002881 PRC-barrel domain; Region: PRC; pfam05239 713604002882 MgtE intracellular N domain; Region: MgtE_N; smart00924 713604002883 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 713604002884 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 713604002885 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 713604002886 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 713604002887 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 713604002888 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 713604002889 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604002890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604002891 active site 713604002892 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604002893 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604002894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604002895 dimer interface [polypeptide binding]; other site 713604002896 conserved gate region; other site 713604002897 putative PBP binding loops; other site 713604002898 ABC-ATPase subunit interface; other site 713604002899 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604002900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604002901 dimer interface [polypeptide binding]; other site 713604002902 conserved gate region; other site 713604002903 putative PBP binding loops; other site 713604002904 ABC-ATPase subunit interface; other site 713604002905 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 713604002906 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 713604002907 Walker A/P-loop; other site 713604002908 ATP binding site [chemical binding]; other site 713604002909 Q-loop/lid; other site 713604002910 ABC transporter signature motif; other site 713604002911 Walker B; other site 713604002912 D-loop; other site 713604002913 H-loop/switch region; other site 713604002914 PspC domain; Region: PspC; pfam04024 713604002915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002917 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 713604002918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002919 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002921 active site 713604002922 phosphorylation site [posttranslational modification] 713604002923 intermolecular recognition site; other site 713604002924 dimerization interface [polypeptide binding]; other site 713604002925 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002926 DNA binding residues [nucleotide binding] 713604002927 dimerization interface [polypeptide binding]; other site 713604002928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604002929 Histidine kinase; Region: HisKA_3; pfam07730 713604002930 CAAX protease self-immunity; Region: Abi; pfam02517 713604002931 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604002932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604002933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604002934 DNA binding residues [nucleotide binding] 713604002935 ParB-like nuclease domain; Region: ParBc; cl02129 713604002936 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604002937 active site 713604002938 metal binding site [ion binding]; metal-binding site 713604002939 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604002940 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 713604002941 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 713604002942 oligomer interface [polypeptide binding]; other site 713604002943 metal binding site [ion binding]; metal-binding site 713604002944 metal binding site [ion binding]; metal-binding site 713604002945 putative Cl binding site [ion binding]; other site 713604002946 basic sphincter; other site 713604002947 hydrophobic gate; other site 713604002948 periplasmic entrance; other site 713604002949 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 713604002950 putative active site [active] 713604002951 putative catalytic site [active] 713604002952 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 713604002953 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 713604002954 nudix motif; other site 713604002955 Bacterial PH domain; Region: DUF304; pfam03703 713604002956 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 713604002957 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 713604002958 active site 713604002959 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 713604002960 MarC family integral membrane protein; Region: MarC; cl00919 713604002961 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604002962 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604002963 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 713604002964 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 713604002965 DEAD-like helicases superfamily; Region: DEXDc; smart00487 713604002966 ATP binding site [chemical binding]; other site 713604002967 Mg++ binding site [ion binding]; other site 713604002968 motif III; other site 713604002969 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604002970 nucleotide binding region [chemical binding]; other site 713604002971 ATP-binding site [chemical binding]; other site 713604002972 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 713604002973 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 713604002974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002976 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 713604002977 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604002978 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604002979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002981 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604002982 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 713604002983 catalytic site [active] 713604002984 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 713604002985 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 713604002986 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 713604002987 ATP binding site [chemical binding]; other site 713604002988 substrate interface [chemical binding]; other site 713604002989 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 713604002990 active site residue [active] 713604002991 TIGR02569 family protein; Region: TIGR02569_actnb 713604002992 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 713604002993 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 713604002994 [4Fe-4S] binding site [ion binding]; other site 713604002995 molybdopterin cofactor binding site; other site 713604002996 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 713604002997 molybdopterin cofactor binding site; other site 713604002998 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604002999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604003000 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 713604003001 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 713604003002 nitrite reductase subunit NirD; Provisional; Region: PRK14989 713604003003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604003004 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 713604003005 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 713604003006 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713604003007 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 713604003008 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 713604003009 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 713604003010 active site 713604003011 DNA binding site [nucleotide binding] 713604003012 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604003013 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604003014 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604003015 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 713604003016 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604003017 HTH domain; Region: HTH_11; pfam08279 713604003018 WYL domain; Region: WYL; pfam13280 713604003019 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 713604003020 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 713604003021 active site 713604003022 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 713604003023 DNA binding site [nucleotide binding] 713604003024 active site 713604003025 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 713604003026 Part of AAA domain; Region: AAA_19; pfam13245 713604003027 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 713604003028 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 713604003029 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 713604003030 Part of AAA domain; Region: AAA_19; pfam13245 713604003031 Family description; Region: UvrD_C_2; pfam13538 713604003032 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 713604003033 Predicted membrane protein [Function unknown]; Region: COG4270 713604003034 Ion channel; Region: Ion_trans_2; pfam07885 713604003035 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 713604003036 TrkA-N domain; Region: TrkA_N; pfam02254 713604003037 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604003038 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 713604003039 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 713604003040 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 713604003041 MoxR-like ATPases [General function prediction only]; Region: COG0714 713604003042 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 713604003043 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 713604003044 Protein of unknown function DUF58; Region: DUF58; pfam01882 713604003045 Integral membrane protein DUF95; Region: DUF95; pfam01944 713604003046 Predicted membrane protein/domain [Function unknown]; Region: COG1714 713604003047 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604003048 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604003049 active site 713604003050 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604003051 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 713604003052 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 713604003053 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 713604003054 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 713604003055 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 713604003056 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 713604003057 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 713604003058 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 713604003059 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 713604003060 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 713604003061 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 713604003062 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 713604003063 putative NADH binding site [chemical binding]; other site 713604003064 putative active site [active] 713604003065 nudix motif; other site 713604003066 putative metal binding site [ion binding]; other site 713604003067 MarR family; Region: MarR_2; pfam12802 713604003068 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604003069 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604003070 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604003071 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604003072 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604003073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604003074 dimer interface [polypeptide binding]; other site 713604003075 putative PBP binding loops; other site 713604003076 ABC-ATPase subunit interface; other site 713604003077 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604003078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604003079 dimer interface [polypeptide binding]; other site 713604003080 conserved gate region; other site 713604003081 putative PBP binding loops; other site 713604003082 ABC-ATPase subunit interface; other site 713604003083 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 713604003084 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 713604003085 NAD binding site [chemical binding]; other site 713604003086 sugar binding site [chemical binding]; other site 713604003087 divalent metal binding site [ion binding]; other site 713604003088 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604003089 dimer interface [polypeptide binding]; other site 713604003090 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 713604003091 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 713604003092 putative hydrophobic ligand binding site [chemical binding]; other site 713604003093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604003094 dimerization interface [polypeptide binding]; other site 713604003095 putative DNA binding site [nucleotide binding]; other site 713604003096 putative Zn2+ binding site [ion binding]; other site 713604003097 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 713604003098 GntP family permease; Region: GntP_permease; pfam02447 713604003099 fructuronate transporter; Provisional; Region: PRK10034; cl15264 713604003100 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 713604003101 ATP-binding site [chemical binding]; other site 713604003102 Gluconate-6-phosphate binding site [chemical binding]; other site 713604003103 Shikimate kinase; Region: SKI; pfam01202 713604003104 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604003105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604003106 DNA-binding site [nucleotide binding]; DNA binding site 713604003107 FCD domain; Region: FCD; pfam07729 713604003108 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 713604003109 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 713604003110 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 713604003111 Low molecular weight phosphatase family; Region: LMWPc; cd00115 713604003112 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 713604003113 active site 713604003114 chorismate mutase; Provisional; Region: PRK09269 713604003115 Chorismate mutase type II; Region: CM_2; cl00693 713604003116 Uncharacterized conserved protein [Function unknown]; Region: COG0327 713604003117 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 713604003118 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 713604003119 Putative zinc ribbon domain; Region: DUF164; pfam02591 713604003120 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 713604003121 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 713604003122 RNA/DNA hybrid binding site [nucleotide binding]; other site 713604003123 active site 713604003124 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604003125 catalytic core [active] 713604003126 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 713604003127 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 713604003128 transmembrane helices; other site 713604003129 AAA ATPase domain; Region: AAA_16; pfam13191 713604003130 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604003132 TPR motif; other site 713604003133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003135 DNA binding residues [nucleotide binding] 713604003136 dimerization interface [polypeptide binding]; other site 713604003137 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 713604003138 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604003139 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604003140 DNA binding residues [nucleotide binding] 713604003141 Domain of unknown function (DUF4142); Region: DUF4142; cl17876 713604003142 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 713604003143 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604003144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604003145 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604003146 AAA-like domain; Region: AAA_10; pfam12846 713604003147 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604003148 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604003149 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 713604003150 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604003151 RNB domain; Region: RNB; pfam00773 713604003152 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 713604003153 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 713604003154 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 713604003155 intersubunit interface [polypeptide binding]; other site 713604003156 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 713604003157 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604003158 NAD(P) binding site [chemical binding]; other site 713604003159 catalytic residues [active] 713604003160 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 713604003161 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604003162 inhibitor-cofactor binding pocket; inhibition site 713604003163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604003164 catalytic residue [active] 713604003165 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 713604003166 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604003167 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604003168 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604003169 DNA-binding site [nucleotide binding]; DNA binding site 713604003170 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 713604003171 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 713604003172 tetrameric interface [polypeptide binding]; other site 713604003173 NAD binding site [chemical binding]; other site 713604003174 catalytic residues [active] 713604003175 substrate binding site [chemical binding]; other site 713604003176 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 713604003177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003178 Walker A/P-loop; other site 713604003179 ATP binding site [chemical binding]; other site 713604003180 Q-loop/lid; other site 713604003181 ABC transporter signature motif; other site 713604003182 Walker B; other site 713604003183 D-loop; other site 713604003184 H-loop/switch region; other site 713604003185 TOBE domain; Region: TOBE_2; pfam08402 713604003186 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604003187 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604003188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604003189 dimer interface [polypeptide binding]; other site 713604003190 conserved gate region; other site 713604003191 putative PBP binding loops; other site 713604003192 ABC-ATPase subunit interface; other site 713604003193 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 713604003194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604003195 dimer interface [polypeptide binding]; other site 713604003196 conserved gate region; other site 713604003197 putative PBP binding loops; other site 713604003198 ABC-ATPase subunit interface; other site 713604003199 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 713604003200 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 713604003201 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 713604003202 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 713604003203 oligomerization interface [polypeptide binding]; other site 713604003204 active site 713604003205 metal binding site [ion binding]; metal-binding site 713604003206 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 713604003207 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 713604003208 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 713604003209 dimer interface [polypeptide binding]; other site 713604003210 putative anticodon binding site; other site 713604003211 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604003212 motif 1; other site 713604003213 dimer interface [polypeptide binding]; other site 713604003214 active site 713604003215 motif 2; other site 713604003216 motif 3; other site 713604003217 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604003218 DinB superfamily; Region: DinB_2; pfam12867 713604003219 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 713604003220 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 713604003221 DNA binding site [nucleotide binding] 713604003222 active site 713604003223 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 713604003224 NAD synthetase; Provisional; Region: PRK13981 713604003225 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 713604003226 multimer interface [polypeptide binding]; other site 713604003227 active site 713604003228 catalytic triad [active] 713604003229 protein interface 1 [polypeptide binding]; other site 713604003230 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 713604003231 homodimer interface [polypeptide binding]; other site 713604003232 NAD binding pocket [chemical binding]; other site 713604003233 ATP binding pocket [chemical binding]; other site 713604003234 Mg binding site [ion binding]; other site 713604003235 active-site loop [active] 713604003236 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 713604003237 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 713604003238 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604003239 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604003240 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 713604003241 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604003242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604003243 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 713604003244 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 713604003245 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604003246 amidase; Provisional; Region: PRK08137 713604003247 Amidase; Region: Amidase; pfam01425 713604003248 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604003249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604003250 putative DNA binding site [nucleotide binding]; other site 713604003251 putative Zn2+ binding site [ion binding]; other site 713604003252 AsnC family; Region: AsnC_trans_reg; pfam01037 713604003253 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 713604003254 active site residue [active] 713604003255 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 713604003256 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 713604003257 catalytic triad [active] 713604003258 Phosphate transporter family; Region: PHO4; cl00396 713604003259 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 713604003260 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 713604003261 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 713604003262 metal binding triad; other site 713604003263 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 713604003264 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 713604003265 metal binding triad; other site 713604003266 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 713604003267 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 713604003268 active site 713604003269 glutamine synthetase, type I; Region: GlnA; TIGR00653 713604003270 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 713604003271 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604003272 RDD family; Region: RDD; pfam06271 713604003273 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 713604003274 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 713604003275 Part of AAA domain; Region: AAA_19; pfam13245 713604003276 Family description; Region: UvrD_C_2; pfam13538 713604003277 HRDC domain; Region: HRDC; pfam00570 713604003278 Transcription factor WhiB; Region: Whib; pfam02467 713604003279 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604003280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604003281 S-adenosylmethionine binding site [chemical binding]; other site 713604003282 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 713604003283 ABC1 family; Region: ABC1; pfam03109 713604003284 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 713604003285 active site 713604003286 ATP binding site [chemical binding]; other site 713604003287 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 713604003288 catalytic loop [active] 713604003289 activation loop (A-loop); other site 713604003290 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 713604003291 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 713604003292 Protein of unknown function DUF45; Region: DUF45; cl00636 713604003293 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 713604003294 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 713604003295 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 713604003296 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604003297 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 713604003298 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 713604003299 hypothetical protein; Validated; Region: PRK00068 713604003300 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604003301 hypothetical protein; Provisional; Region: PRK08244 713604003302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003303 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604003304 peptide chain release factor 2; Validated; Region: prfB; PRK00578 713604003305 This domain is found in peptide chain release factors; Region: PCRF; smart00937 713604003306 RF-1 domain; Region: RF-1; pfam00472 713604003307 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 713604003308 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003309 Walker A/P-loop; other site 713604003310 ATP binding site [chemical binding]; other site 713604003311 Q-loop/lid; other site 713604003312 ABC transporter signature motif; other site 713604003313 Walker B; other site 713604003314 D-loop; other site 713604003315 H-loop/switch region; other site 713604003316 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 713604003317 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 713604003318 SmpB-tmRNA interface; other site 713604003319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 713604003320 active site 713604003321 Acyltransferase family; Region: Acyl_transf_3; pfam01757 713604003322 Domain of unknown function (DUF336); Region: DUF336; cl01249 713604003323 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604003325 active site 713604003326 phosphorylation site [posttranslational modification] 713604003327 intermolecular recognition site; other site 713604003328 dimerization interface [polypeptide binding]; other site 713604003329 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003330 DNA binding residues [nucleotide binding] 713604003331 dimerization interface [polypeptide binding]; other site 713604003332 Putative sensor; Region: Sensor; pfam13796 713604003333 Histidine kinase; Region: HisKA_3; pfam07730 713604003334 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604003335 Mg2+ binding site [ion binding]; other site 713604003336 G-X-G motif; other site 713604003337 Putative sensor; Region: Sensor; pfam13796 713604003338 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604003339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604003340 metal binding site [ion binding]; metal-binding site 713604003341 active site 713604003342 I-site; other site 713604003343 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604003344 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604003345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604003346 putative DNA binding site [nucleotide binding]; other site 713604003347 putative Zn2+ binding site [ion binding]; other site 713604003348 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604003349 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 713604003350 active sites [active] 713604003351 tetramer interface [polypeptide binding]; other site 713604003352 urocanate hydratase; Provisional; Region: PRK05414 713604003353 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 713604003354 allantoate amidohydrolase; Reviewed; Region: PRK09290 713604003355 active site 713604003356 metal binding site [ion binding]; metal-binding site 713604003357 dimer interface [polypeptide binding]; other site 713604003358 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 713604003359 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604003360 active site 713604003361 imidazolonepropionase; Provisional; Region: PRK14085 713604003362 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604003363 active site 713604003364 hypothetical protein; Provisional; Region: PRK06847 713604003365 hypothetical protein; Provisional; Region: PRK07236 713604003366 Lipase (class 2); Region: Lipase_2; pfam01674 713604003367 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 713604003368 active site 713604003369 catalytic triad [active] 713604003370 dimer interface [polypeptide binding]; other site 713604003371 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 713604003372 Histidine kinase; Region: HisKA_3; pfam07730 713604003373 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604003374 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604003376 active site 713604003377 phosphorylation site [posttranslational modification] 713604003378 intermolecular recognition site; other site 713604003379 dimerization interface [polypeptide binding]; other site 713604003380 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003381 DNA binding residues [nucleotide binding] 713604003382 dimerization interface [polypeptide binding]; other site 713604003383 hypothetical protein; Provisional; Region: PRK06753 713604003384 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604003385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 713604003386 cyclase homology domain; Region: CHD; cd07302 713604003387 nucleotidyl binding site; other site 713604003388 metal binding site [ion binding]; metal-binding site 713604003389 dimer interface [polypeptide binding]; other site 713604003390 NB-ARC domain; Region: NB-ARC; pfam00931 713604003391 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003392 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003393 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604003395 binding surface 713604003396 TPR motif; other site 713604003397 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003398 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003399 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604003400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003401 Walker A/P-loop; other site 713604003402 ATP binding site [chemical binding]; other site 713604003403 Q-loop/lid; other site 713604003404 ABC transporter signature motif; other site 713604003405 Walker B; other site 713604003406 D-loop; other site 713604003407 H-loop/switch region; other site 713604003408 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 713604003409 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 713604003410 ATP binding site [chemical binding]; other site 713604003411 putative Mg++ binding site [ion binding]; other site 713604003412 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604003413 nucleotide binding region [chemical binding]; other site 713604003414 ATP-binding site [chemical binding]; other site 713604003415 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 713604003416 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 713604003417 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604003418 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604003419 substrate binding pocket [chemical binding]; other site 713604003420 membrane-bound complex binding site; other site 713604003421 hinge residues; other site 713604003422 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 713604003423 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 713604003424 catalytic residues [active] 713604003425 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604003426 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604003427 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 713604003428 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 713604003429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604003430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604003431 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604003432 DinB superfamily; Region: DinB_2; pfam12867 713604003433 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604003434 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604003435 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604003436 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 713604003437 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604003438 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604003439 putative sugar binding sites [chemical binding]; other site 713604003440 Q-X-W motif; other site 713604003441 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 713604003442 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 713604003443 CAP-like domain; other site 713604003444 active site 713604003445 primary dimer interface [polypeptide binding]; other site 713604003446 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604003447 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 713604003448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604003449 ATP binding site [chemical binding]; other site 713604003450 Mg2+ binding site [ion binding]; other site 713604003451 G-X-G motif; other site 713604003452 DNA gyrase B; Region: DNA_gyraseB; pfam00204 713604003453 ATP binding site [chemical binding]; other site 713604003454 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 713604003455 active site 713604003456 metal binding site [ion binding]; metal-binding site 713604003457 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 713604003458 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 713604003459 putative active site [active] 713604003460 catalytic site [active] 713604003461 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 713604003462 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604003463 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604003464 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604003465 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 713604003466 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604003467 RibD C-terminal domain; Region: RibD_C; cl17279 713604003468 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604003469 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604003470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003472 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604003473 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604003474 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604003475 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604003476 intermolecular salt bridges; other site 713604003477 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604003478 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604003479 TM-ABC transporter signature motif; other site 713604003480 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604003481 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604003482 TM-ABC transporter signature motif; other site 713604003483 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 713604003484 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604003485 Walker A/P-loop; other site 713604003486 ATP binding site [chemical binding]; other site 713604003487 Q-loop/lid; other site 713604003488 ABC transporter signature motif; other site 713604003489 Walker B; other site 713604003490 D-loop; other site 713604003491 H-loop/switch region; other site 713604003492 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604003493 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 713604003494 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604003495 putative ligand binding site [chemical binding]; other site 713604003496 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604003497 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604003498 DNA binding site [nucleotide binding] 713604003499 domain linker motif; other site 713604003500 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604003501 ligand binding site [chemical binding]; other site 713604003502 dimerization interface [polypeptide binding]; other site 713604003503 Predicted ATPase [General function prediction only]; Region: COG4637 713604003504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003505 Walker A/P-loop; other site 713604003506 ATP binding site [chemical binding]; other site 713604003507 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604003508 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604003509 short chain dehydrogenase; Validated; Region: PRK08264 713604003510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604003511 NAD(P) binding site [chemical binding]; other site 713604003512 active site 713604003513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003515 WHG domain; Region: WHG; pfam13305 713604003516 Phosphotransferase enzyme family; Region: APH; pfam01636 713604003517 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604003518 active site 713604003519 ATP binding site [chemical binding]; other site 713604003520 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604003521 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 713604003522 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 713604003523 FAD binding pocket [chemical binding]; other site 713604003524 FAD binding motif [chemical binding]; other site 713604003525 phosphate binding motif [ion binding]; other site 713604003526 NAD binding pocket [chemical binding]; other site 713604003527 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 713604003528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003529 Walker A/P-loop; other site 713604003530 ATP binding site [chemical binding]; other site 713604003531 Q-loop/lid; other site 713604003532 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 713604003533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003534 Walker A/P-loop; other site 713604003535 ATP binding site [chemical binding]; other site 713604003536 Q-loop/lid; other site 713604003537 ABC transporter signature motif; other site 713604003538 Walker B; other site 713604003539 D-loop; other site 713604003540 H-loop/switch region; other site 713604003541 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604003542 Methyltransferase domain; Region: Methyltransf_11; pfam08241 713604003543 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604003544 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 713604003545 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604003546 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 713604003547 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 713604003548 substrate binding pocket [chemical binding]; other site 713604003549 substrate-Mg2+ binding site; other site 713604003550 aspartate-rich region 1; other site 713604003551 active site lid residues [active] 713604003552 aspartate-rich region 2; other site 713604003553 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 713604003554 substrate binding pocket [chemical binding]; other site 713604003555 substrate-Mg2+ binding site; other site 713604003556 aspartate-rich region 1; other site 713604003557 aspartate-rich region 2; other site 713604003558 Predicted acetyltransferase [General function prediction only]; Region: COG2388 713604003559 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604003560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604003561 S-adenosylmethionine binding site [chemical binding]; other site 713604003562 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604003563 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604003564 putative sugar binding sites [chemical binding]; other site 713604003565 Q-X-W motif; other site 713604003566 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604003567 classical (c) SDRs; Region: SDR_c; cd05233 713604003568 NAD(P) binding site [chemical binding]; other site 713604003569 active site 713604003570 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604003571 Cytochrome P450; Region: p450; cl12078 713604003572 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 713604003573 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 713604003574 Dimer interface [polypeptide binding]; other site 713604003575 anticodon binding site; other site 713604003576 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604003577 motif 1; other site 713604003578 dimer interface [polypeptide binding]; other site 713604003579 active site 713604003580 motif 2; other site 713604003581 motif 3; other site 713604003582 short chain dehydrogenase; Provisional; Region: PRK07454 713604003583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604003584 NAD(P) binding site [chemical binding]; other site 713604003585 active site 713604003586 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604003587 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604003588 haloalkane dehalogenase; Provisional; Region: PRK03592 713604003589 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604003590 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604003591 sugar binding site [chemical binding]; other site 713604003592 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604003593 Interdomain contacts; other site 713604003594 Cytokine receptor motif; other site 713604003595 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604003596 Interdomain contacts; other site 713604003597 Cytokine receptor motif; other site 713604003598 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604003599 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604003600 Uncharacterized conserved protein [Function unknown]; Region: COG0393 713604003601 Uncharacterized conserved protein [Function unknown]; Region: COG0393 713604003602 Uncharacterized conserved protein [Function unknown]; Region: COG0393 713604003603 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604003604 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 713604003605 substrate binding site [chemical binding]; other site 713604003606 ATP binding site [chemical binding]; other site 713604003607 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 713604003608 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 713604003609 NAD binding site [chemical binding]; other site 713604003610 sugar binding site [chemical binding]; other site 713604003611 divalent metal binding site [ion binding]; other site 713604003612 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604003613 dimer interface [polypeptide binding]; other site 713604003614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604003615 NAD(P) binding site [chemical binding]; other site 713604003616 active site 713604003617 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 713604003618 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604003619 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 713604003620 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 713604003621 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 713604003622 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 713604003623 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 713604003624 NAD(P) binding site [chemical binding]; other site 713604003625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003626 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604003627 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604003628 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604003629 TIGR03086 family protein; Region: TIGR03086 713604003630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003632 Domain of unknown function DUF11; Region: DUF11; cl17728 713604003633 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604003634 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003636 DNA binding residues [nucleotide binding] 713604003637 dimerization interface [polypeptide binding]; other site 713604003638 Rhomboid family; Region: Rhomboid; pfam01694 713604003639 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 713604003640 dihydropteroate synthase; Region: DHPS; TIGR01496 713604003641 substrate binding pocket [chemical binding]; other site 713604003642 dimer interface [polypeptide binding]; other site 713604003643 inhibitor binding site; inhibition site 713604003644 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604003645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003646 Walker A/P-loop; other site 713604003647 ATP binding site [chemical binding]; other site 713604003648 Q-loop/lid; other site 713604003649 ABC transporter signature motif; other site 713604003650 Walker B; other site 713604003651 D-loop; other site 713604003652 H-loop/switch region; other site 713604003653 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 713604003654 PGAP1-like protein; Region: PGAP1; pfam07819 713604003655 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003656 CHAT domain; Region: CHAT; cl17868 713604003657 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 713604003658 active site 713604003659 catalytic residues [active] 713604003660 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604003661 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604003662 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 713604003663 substrate binding pocket [chemical binding]; other site 713604003664 catalytic residues [active] 713604003665 EamA-like transporter family; Region: EamA; pfam00892 713604003666 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 713604003667 EamA-like transporter family; Region: EamA; pfam00892 713604003668 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604003669 MarR family; Region: MarR_2; cl17246 713604003670 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604003671 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 713604003672 active site 713604003673 phosphorylation site [posttranslational modification] 713604003674 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 713604003675 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 713604003676 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 713604003677 active pocket/dimerization site; other site 713604003678 active site 713604003679 phosphorylation site [posttranslational modification] 713604003680 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 713604003681 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604003682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604003683 DNA-binding site [nucleotide binding]; DNA binding site 713604003684 UTRA domain; Region: UTRA; pfam07702 713604003685 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604003686 DNA binding site [nucleotide binding] 713604003687 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604003688 NB-ARC domain; Region: NB-ARC; pfam00931 713604003689 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604003691 binding surface 713604003692 TPR motif; other site 713604003693 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003694 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003695 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604003696 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604003697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604003698 putative substrate translocation pore; other site 713604003699 NMT1-like family; Region: NMT1_2; pfam13379 713604003700 NMT1/THI5 like; Region: NMT1; pfam09084 713604003701 membrane-bound complex binding site; other site 713604003702 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604003703 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 713604003704 Walker A/P-loop; other site 713604003705 ATP binding site [chemical binding]; other site 713604003706 Q-loop/lid; other site 713604003707 ABC transporter signature motif; other site 713604003708 Walker B; other site 713604003709 D-loop; other site 713604003710 H-loop/switch region; other site 713604003711 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 713604003712 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 713604003713 Walker A/P-loop; other site 713604003714 ATP binding site [chemical binding]; other site 713604003715 Q-loop/lid; other site 713604003716 ABC transporter signature motif; other site 713604003717 Walker B; other site 713604003718 D-loop; other site 713604003719 H-loop/switch region; other site 713604003720 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 713604003721 TM-ABC transporter signature motif; other site 713604003722 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 713604003723 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 713604003724 TM-ABC transporter signature motif; other site 713604003725 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604003726 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 713604003727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003729 NACHT domain; Region: NACHT; pfam05729 713604003730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604003732 active site 713604003733 phosphorylation site [posttranslational modification] 713604003734 intermolecular recognition site; other site 713604003735 dimerization interface [polypeptide binding]; other site 713604003736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003737 DNA binding residues [nucleotide binding] 713604003738 Putative sensor; Region: Sensor; pfam13796 713604003739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604003740 Histidine kinase; Region: HisKA_3; pfam07730 713604003741 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604003742 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604003743 Walker A/P-loop; other site 713604003744 ATP binding site [chemical binding]; other site 713604003745 Q-loop/lid; other site 713604003746 ABC transporter signature motif; other site 713604003747 Walker B; other site 713604003748 D-loop; other site 713604003749 H-loop/switch region; other site 713604003750 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 713604003751 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 713604003752 FtsX-like permease family; Region: FtsX; pfam02687 713604003753 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 713604003754 Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs; Region: CE4_SlAXE_like; cd10953 713604003755 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604003756 NodB motif; other site 713604003757 active site 713604003758 catalytic site [active] 713604003759 Zn binding site [ion binding]; other site 713604003760 dimer interface [polypeptide binding]; other site 713604003761 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604003762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003763 Walker A/P-loop; other site 713604003764 ATP binding site [chemical binding]; other site 713604003765 Q-loop/lid; other site 713604003766 ABC transporter signature motif; other site 713604003767 Walker B; other site 713604003768 D-loop; other site 713604003769 H-loop/switch region; other site 713604003770 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604003771 Uncharacterized conserved protein [Function unknown]; Region: COG3391 713604003772 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604003773 Phosphoesterase family; Region: Phosphoesterase; pfam04185 713604003774 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604003775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604003776 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604003777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604003778 putative substrate translocation pore; other site 713604003779 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 713604003780 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604003781 NAD binding site [chemical binding]; other site 713604003782 catalytic residues [active] 713604003783 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 713604003784 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604003785 Glucose dehydrogenase; Region: glucose_DH; cd08230 713604003786 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604003787 NADP binding site [chemical binding]; other site 713604003788 catalytic Zn binding site [ion binding]; other site 713604003789 structural Zn binding site [ion binding]; other site 713604003790 dimer interface [polypeptide binding]; other site 713604003791 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604003792 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604003793 Q-X-W motif; other site 713604003794 putative sugar binding sites [chemical binding]; other site 713604003795 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604003796 Chitin binding domain; Region: Chitin_bind_3; pfam03067 713604003797 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604003798 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604003799 Protein of unknown function DUF72; Region: DUF72; pfam01904 713604003800 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 713604003801 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 713604003802 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 713604003803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 713604003804 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604003805 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604003806 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604003807 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604003808 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 713604003809 Zn binding site [ion binding]; other site 713604003810 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604003811 MarR family; Region: MarR_2; cl17246 713604003812 RHS Repeat; Region: RHS_repeat; cl11982 713604003813 RHS Repeat; Region: RHS_repeat; pfam05593 713604003814 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604003815 RHS Repeat; Region: RHS_repeat; cl11982 713604003816 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604003817 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604003818 RHS Repeat; Region: RHS_repeat; cl11982 713604003819 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604003820 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604003821 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 713604003822 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 713604003823 DinB superfamily; Region: DinB_2; pfam12867 713604003824 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 713604003825 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604003826 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604003827 putative NAD(P) binding site [chemical binding]; other site 713604003828 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604003829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003830 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604003831 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604003832 putative NAD(P) binding site [chemical binding]; other site 713604003833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604003834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604003835 ATP binding site [chemical binding]; other site 713604003836 Mg2+ binding site [ion binding]; other site 713604003837 G-X-G motif; other site 713604003838 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 713604003839 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604003840 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604003841 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604003842 G1 box; other site 713604003843 GTP/Mg2+ binding site [chemical binding]; other site 713604003844 G2 box; other site 713604003845 Switch I region; other site 713604003846 G3 box; other site 713604003847 Switch II region; other site 713604003848 G5 box; other site 713604003849 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604003850 short chain dehydrogenase; Provisional; Region: PRK06523 713604003851 classical (c) SDRs; Region: SDR_c; cd05233 713604003852 NAD(P) binding site [chemical binding]; other site 713604003853 active site 713604003854 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604003855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604003856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 713604003857 dimerization interface [polypeptide binding]; other site 713604003858 short chain dehydrogenase; Provisional; Region: PRK06500 713604003859 classical (c) SDRs; Region: SDR_c; cd05233 713604003860 NAD(P) binding site [chemical binding]; other site 713604003861 active site 713604003862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003864 hypothetical protein; Provisional; Region: PRK06184 713604003865 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604003866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604003869 Transposase; Region: HTH_Tnp_1; cl17663 713604003870 putative transposase OrfB; Reviewed; Region: PHA02517 713604003871 HTH-like domain; Region: HTH_21; pfam13276 713604003872 Integrase core domain; Region: rve; pfam00665 713604003873 Integrase core domain; Region: rve_3; pfam13683 713604003874 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 713604003875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604003876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003878 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604003879 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604003880 active site 713604003881 catalytic tetrad [active] 713604003882 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604003883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604003884 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604003885 DNA binding residues [nucleotide binding] 713604003886 putative transposase OrfB; Reviewed; Region: PHA02517 713604003887 HTH-like domain; Region: HTH_21; pfam13276 713604003888 Integrase core domain; Region: rve; pfam00665 713604003889 Integrase core domain; Region: rve_3; pfam13683 713604003890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604003891 Transposase; Region: HTH_Tnp_1; cl17663 713604003892 AAA ATPase domain; Region: AAA_16; pfam13191 713604003893 NB-ARC domain; Region: NB-ARC; pfam00931 713604003894 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604003896 binding surface 713604003897 TPR motif; other site 713604003898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604003899 binding surface 713604003900 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003901 TPR motif; other site 713604003902 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003903 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604003904 MarR family; Region: MarR_2; pfam12802 713604003905 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 713604003906 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 713604003907 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604003908 MarR family; Region: MarR; pfam01047 713604003909 DoxX-like family; Region: DoxX_2; pfam13564 713604003910 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604003911 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604003912 putative NAD(P) binding site [chemical binding]; other site 713604003913 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 713604003914 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 713604003915 putative active site [active] 713604003916 metal binding site [ion binding]; metal-binding site 713604003917 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 713604003918 active site 713604003919 catalytic residues [active] 713604003920 metal binding site [ion binding]; metal-binding site 713604003921 AMP-binding domain protein; Validated; Region: PRK08315 713604003922 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604003923 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 713604003924 acyl-activating enzyme (AAE) consensus motif; other site 713604003925 putative AMP binding site [chemical binding]; other site 713604003926 putative active site [active] 713604003927 putative CoA binding site [chemical binding]; other site 713604003928 Predicted acyl esterases [General function prediction only]; Region: COG2936 713604003929 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604003930 GAF domain; Region: GAF_2; pfam13185 713604003931 GAF domain; Region: GAF; cl17456 713604003932 Histidine kinase; Region: HisKA_3; pfam07730 713604003933 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604003934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604003935 ATP binding site [chemical binding]; other site 713604003936 Mg2+ binding site [ion binding]; other site 713604003937 G-X-G motif; other site 713604003938 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 713604003940 active site 713604003941 phosphorylation site [posttranslational modification] 713604003942 intermolecular recognition site; other site 713604003943 dimerization interface [polypeptide binding]; other site 713604003944 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003945 DNA binding residues [nucleotide binding] 713604003946 dimerization interface [polypeptide binding]; other site 713604003947 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 713604003948 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604003949 active site 713604003950 Int/Topo IB signature motif; other site 713604003951 DNA binding site [nucleotide binding] 713604003952 Helix-turn-helix domain; Region: HTH_17; cl17695 713604003953 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604003954 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604003955 putative sugar binding sites [chemical binding]; other site 713604003956 Q-X-W motif; other site 713604003957 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 713604003958 ribonuclease Z; Reviewed; Region: PRK00055 713604003959 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 713604003960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604003961 active site 713604003962 phosphorylation site [posttranslational modification] 713604003963 intermolecular recognition site; other site 713604003964 dimerization interface [polypeptide binding]; other site 713604003965 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 713604003966 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604003967 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604003968 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604003969 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604003970 ligand binding site [chemical binding]; other site 713604003971 flexible hinge region; other site 713604003972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604003973 ATP binding site [chemical binding]; other site 713604003974 Mg2+ binding site [ion binding]; other site 713604003975 G-X-G motif; other site 713604003976 Carboxylesterase family; Region: COesterase; pfam00135 713604003977 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604003978 substrate binding pocket [chemical binding]; other site 713604003979 catalytic triad [active] 713604003980 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 713604003981 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 713604003982 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604003983 von Willebrand factor type A domain; Region: VWA_2; pfam13519 713604003984 metal ion-dependent adhesion site (MIDAS); other site 713604003985 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 713604003986 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 713604003987 Transposase; Region: DEDD_Tnp_IS110; pfam01548 713604003988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 713604003989 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 713604003990 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 713604003991 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 713604003992 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 713604003993 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 713604003994 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 713604003995 Moco binding site; other site 713604003996 metal coordination site [ion binding]; other site 713604003997 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 713604003998 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 713604003999 FAD binding pocket [chemical binding]; other site 713604004000 FAD binding motif [chemical binding]; other site 713604004001 phosphate binding motif [ion binding]; other site 713604004002 beta-alpha-beta structure motif; other site 713604004003 NAD binding pocket [chemical binding]; other site 713604004004 Right handed beta helix region; Region: Beta_helix; pfam13229 713604004005 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604004006 Interdomain contacts; other site 713604004007 Cytokine receptor motif; other site 713604004008 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604004009 Interdomain contacts; other site 713604004010 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604004011 DNA binding residues [nucleotide binding] 713604004012 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604004013 nucleotide binding site [chemical binding]; other site 713604004014 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604004015 Dynamin family; Region: Dynamin_N; pfam00350 713604004016 G1 box; other site 713604004017 GTP/Mg2+ binding site [chemical binding]; other site 713604004018 G2 box; other site 713604004019 Switch I region; other site 713604004020 G3 box; other site 713604004021 Switch II region; other site 713604004022 G4 box; other site 713604004023 G5 box; other site 713604004024 AAA domain; Region: AAA_28; pfam13521 713604004025 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 713604004026 homotrimer interaction site [polypeptide binding]; other site 713604004027 putative active site [active] 713604004028 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604004029 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604004030 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604004031 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604004032 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604004033 acyl-activating enzyme (AAE) consensus motif; other site 713604004034 acyl-activating enzyme (AAE) consensus motif; other site 713604004035 putative AMP binding site [chemical binding]; other site 713604004036 putative active site [active] 713604004037 putative CoA binding site [chemical binding]; other site 713604004038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004040 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604004041 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604004042 catalytic residue [active] 713604004043 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604004044 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 713604004045 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604004046 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604004047 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604004048 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604004049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604004050 substrate binding pocket [chemical binding]; other site 713604004051 membrane-bound complex binding site; other site 713604004052 hinge residues; other site 713604004053 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 713604004054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604004055 dimer interface [polypeptide binding]; other site 713604004056 conserved gate region; other site 713604004057 putative PBP binding loops; other site 713604004058 ABC-ATPase subunit interface; other site 713604004059 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 713604004060 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 713604004061 Walker A/P-loop; other site 713604004062 ATP binding site [chemical binding]; other site 713604004063 Q-loop/lid; other site 713604004064 ABC transporter signature motif; other site 713604004065 Walker B; other site 713604004066 D-loop; other site 713604004067 H-loop/switch region; other site 713604004068 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604004069 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604004070 catalytic residue [active] 713604004071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 713604004072 YheO-like PAS domain; Region: PAS_6; pfam08348 713604004073 HTH domain; Region: HTH_22; pfam13309 713604004074 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604004075 active site 713604004076 TDP-binding site; other site 713604004077 glycosyltransferase, MGT family; Region: MGT; TIGR01426 713604004078 acceptor substrate-binding pocket; other site 713604004079 homodimer interface [polypeptide binding]; other site 713604004080 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604004081 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604004082 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604004083 Walker A/P-loop; other site 713604004084 ATP binding site [chemical binding]; other site 713604004085 Q-loop/lid; other site 713604004086 ABC transporter signature motif; other site 713604004087 Walker B; other site 713604004088 D-loop; other site 713604004089 H-loop/switch region; other site 713604004090 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604004091 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 713604004092 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604004093 DNA polymerase IV; Provisional; Region: PRK03348 713604004094 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 713604004095 active site 713604004096 DNA binding site [nucleotide binding] 713604004097 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 713604004098 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604004099 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004100 DNA-binding site [nucleotide binding]; DNA binding site 713604004101 FCD domain; Region: FCD; pfam07729 713604004102 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604004103 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604004104 TM-ABC transporter signature motif; other site 713604004105 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 713604004106 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604004107 Walker A/P-loop; other site 713604004108 ATP binding site [chemical binding]; other site 713604004109 Q-loop/lid; other site 713604004110 ABC transporter signature motif; other site 713604004111 Walker B; other site 713604004112 D-loop; other site 713604004113 H-loop/switch region; other site 713604004114 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604004115 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 713604004116 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604004117 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 713604004118 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 713604004119 putative active site [active] 713604004120 putative metal binding site [ion binding]; other site 713604004121 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 713604004122 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 713604004123 substrate binding pocket [chemical binding]; other site 713604004124 chain length determination region; other site 713604004125 substrate-Mg2+ binding site; other site 713604004126 catalytic residues [active] 713604004127 aspartate-rich region 1; other site 713604004128 active site lid residues [active] 713604004129 aspartate-rich region 2; other site 713604004130 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604004131 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604004132 ligand binding site [chemical binding]; other site 713604004133 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604004134 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604004135 ligand binding site [chemical binding]; other site 713604004136 flexible hinge region; other site 713604004137 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 713604004138 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 713604004139 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604004140 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 713604004141 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 713604004142 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 713604004143 potential frameshift: common BLAST hit: gi|300783451|ref|YP_003763742.1| SARP family transcriptional regulator 713604004144 PhoD-like phosphatase; Region: PhoD; pfam09423 713604004145 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 713604004146 putative active site [active] 713604004147 putative metal binding site [ion binding]; other site 713604004148 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 713604004149 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 713604004150 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 713604004151 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 713604004152 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604004153 alpha-glucosidase; Provisional; Region: PRK10137 713604004154 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 713604004155 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604004156 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604004157 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 713604004158 peptidase domain interface [polypeptide binding]; other site 713604004159 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604004160 active site 713604004161 catalytic triad [active] 713604004162 calcium binding site [ion binding]; other site 713604004163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604004164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604004165 ATP binding site [chemical binding]; other site 713604004166 Mg2+ binding site [ion binding]; other site 713604004167 G-X-G motif; other site 713604004168 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604004169 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 713604004170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604004171 NAD(P) binding site [chemical binding]; other site 713604004172 active site 713604004173 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 713604004174 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 713604004175 NMT1-like family; Region: NMT1_2; pfam13379 713604004176 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 713604004177 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604004178 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604004179 Walker A/P-loop; other site 713604004180 ATP binding site [chemical binding]; other site 713604004181 Q-loop/lid; other site 713604004182 ABC transporter signature motif; other site 713604004183 Walker B; other site 713604004184 D-loop; other site 713604004185 H-loop/switch region; other site 713604004186 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604004187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604004188 dimer interface [polypeptide binding]; other site 713604004189 conserved gate region; other site 713604004190 putative PBP binding loops; other site 713604004191 ABC-ATPase subunit interface; other site 713604004192 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 713604004193 Strictosidine synthase; Region: Str_synth; pfam03088 713604004194 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 713604004195 DEAD-like helicases superfamily; Region: DEXDc; smart00487 713604004196 ATP binding site [chemical binding]; other site 713604004197 Mg++ binding site [ion binding]; other site 713604004198 motif III; other site 713604004199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604004200 nucleotide binding region [chemical binding]; other site 713604004201 ATP-binding site [chemical binding]; other site 713604004202 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604004203 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604004204 active site 713604004205 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604004206 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 713604004207 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 713604004208 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 713604004209 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 713604004210 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 713604004211 RNA binding site [nucleotide binding]; other site 713604004212 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 713604004213 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 713604004214 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 713604004215 putative active site [active] 713604004216 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 713604004217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604004218 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604004219 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604004220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604004221 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604004222 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 713604004223 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604004224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604004225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004227 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604004228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004230 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604004231 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 713604004232 acyl-activating enzyme (AAE) consensus motif; other site 713604004233 AMP binding site [chemical binding]; other site 713604004234 active site 713604004235 CoA binding site [chemical binding]; other site 713604004236 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604004237 CoenzymeA binding site [chemical binding]; other site 713604004238 subunit interaction site [polypeptide binding]; other site 713604004239 PHB binding site; other site 713604004240 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 713604004241 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 713604004242 substrate binding site [chemical binding]; other site 713604004243 dimer interface [polypeptide binding]; other site 713604004244 NADP binding site [chemical binding]; other site 713604004245 catalytic residues [active] 713604004246 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604004247 active site 2 [active] 713604004248 active site 1 [active] 713604004249 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 713604004250 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 713604004251 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 713604004252 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 713604004253 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 713604004254 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 713604004255 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 713604004256 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 713604004257 FAD binding pocket [chemical binding]; other site 713604004258 FAD binding motif [chemical binding]; other site 713604004259 phosphate binding motif [ion binding]; other site 713604004260 beta-alpha-beta structure motif; other site 713604004261 NAD(p) ribose binding residues [chemical binding]; other site 713604004262 NAD binding pocket [chemical binding]; other site 713604004263 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 713604004264 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604004265 catalytic loop [active] 713604004266 iron binding site [ion binding]; other site 713604004267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604004268 non-specific DNA binding site [nucleotide binding]; other site 713604004269 salt bridge; other site 713604004270 sequence-specific DNA binding site [nucleotide binding]; other site 713604004271 cyclase homology domain; Region: CHD; cd07302 713604004272 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 713604004273 nucleotidyl binding site; other site 713604004274 metal binding site [ion binding]; metal-binding site 713604004275 dimer interface [polypeptide binding]; other site 713604004276 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604004277 Ligand Binding Site [chemical binding]; other site 713604004278 DivIVA protein; Region: DivIVA; pfam05103 713604004279 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604004280 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 713604004281 NAD(P) binding site [chemical binding]; other site 713604004282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004284 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 713604004285 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604004286 dimer interface [polypeptide binding]; other site 713604004287 substrate binding site [chemical binding]; other site 713604004288 metal binding site [ion binding]; metal-binding site 713604004289 putative acyltransferase; Provisional; Region: PRK05790 713604004290 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604004291 dimer interface [polypeptide binding]; other site 713604004292 active site 713604004293 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 713604004294 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 713604004295 Walker A; other site 713604004296 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 713604004297 active site 713604004298 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604004299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004300 DNA-binding site [nucleotide binding]; DNA binding site 713604004301 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604004302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004303 homodimer interface [polypeptide binding]; other site 713604004304 catalytic residue [active] 713604004305 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604004306 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604004307 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 713604004308 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 713604004309 tetramer interface [polypeptide binding]; other site 713604004310 active site 713604004311 Mg2+/Mn2+ binding site [ion binding]; other site 713604004312 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 713604004313 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 713604004314 Na binding site [ion binding]; other site 713604004315 Protein of unknown function, DUF485; Region: DUF485; pfam04341 713604004316 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604004317 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604004318 Na binding site [ion binding]; other site 713604004319 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 713604004320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604004321 active site 713604004322 phosphorylation site [posttranslational modification] 713604004323 intermolecular recognition site; other site 713604004324 dimerization interface [polypeptide binding]; other site 713604004325 LytTr DNA-binding domain; Region: LytTR; smart00850 713604004326 Histidine kinase; Region: His_kinase; pfam06580 713604004327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604004328 ATP binding site [chemical binding]; other site 713604004329 Mg2+ binding site [ion binding]; other site 713604004330 G-X-G motif; other site 713604004331 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 713604004332 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 713604004333 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 713604004334 putative ligand binding site [chemical binding]; other site 713604004335 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604004336 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604004337 TM-ABC transporter signature motif; other site 713604004338 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604004339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604004340 Walker A/P-loop; other site 713604004341 ATP binding site [chemical binding]; other site 713604004342 Q-loop/lid; other site 713604004343 ABC transporter signature motif; other site 713604004344 Walker B; other site 713604004345 D-loop; other site 713604004346 H-loop/switch region; other site 713604004347 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 713604004348 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 713604004349 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604004350 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604004351 DNA binding site [nucleotide binding] 713604004352 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604004353 dimerization interface [polypeptide binding]; other site 713604004354 ligand binding site [chemical binding]; other site 713604004355 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604004356 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604004357 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604004358 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604004359 integral membrane protein; Region: integ_memb_HG; TIGR03954 713604004360 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604004361 MarR family; Region: MarR; pfam01047 713604004362 Domain of unknown function DUF77; Region: DUF77; pfam01910 713604004363 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632 713604004364 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 713604004365 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 713604004366 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604004367 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604004368 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 713604004369 putative homodimer interface [polypeptide binding]; other site 713604004370 putative active site pocket [active] 713604004371 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 713604004372 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604004373 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604004374 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 713604004375 active site residue [active] 713604004376 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 713604004377 Immunoglobulin domain; Region: Ig; cl11960 713604004378 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604004379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604004380 Walker A/P-loop; other site 713604004381 ATP binding site [chemical binding]; other site 713604004382 Q-loop/lid; other site 713604004383 ABC transporter signature motif; other site 713604004384 Walker B; other site 713604004385 D-loop; other site 713604004386 H-loop/switch region; other site 713604004387 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 713604004388 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604004389 substrate binding site [chemical binding]; other site 713604004390 oxyanion hole (OAH) forming residues; other site 713604004391 trimer interface [polypeptide binding]; other site 713604004392 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604004393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604004394 S-adenosylmethionine binding site [chemical binding]; other site 713604004395 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 713604004396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 713604004397 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604004398 LysR substrate binding domain; Region: LysR_substrate; pfam03466 713604004399 dimerization interface [polypeptide binding]; other site 713604004400 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 713604004401 active site 713604004402 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 713604004403 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604004404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004405 DNA-binding site [nucleotide binding]; DNA binding site 713604004406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004408 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604004409 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604004410 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604004411 hypothetical protein; Provisional; Region: PRK08244 713604004412 hypothetical protein; Provisional; Region: PRK07236 713604004413 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604004414 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604004415 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604004416 MarR family; Region: MarR_2; pfam12802 713604004417 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604004418 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604004419 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604004420 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604004421 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604004422 active site 713604004423 catalytic tetrad [active] 713604004424 hypothetical protein; Provisional; Region: PRK06834 713604004425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604004426 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604004427 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604004428 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604004429 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 713604004430 active site 713604004431 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 713604004432 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 713604004433 trimer interface [polypeptide binding]; other site 713604004434 active site 713604004435 substrate binding site [chemical binding]; other site 713604004436 CoA binding site [chemical binding]; other site 713604004437 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 713604004438 threonine dehydratase; Validated; Region: PRK08639 713604004439 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 713604004440 tetramer interface [polypeptide binding]; other site 713604004441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004442 catalytic residue [active] 713604004443 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 713604004444 putative Ile/Val binding site [chemical binding]; other site 713604004445 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604004446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604004447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604004448 DNA binding residues [nucleotide binding] 713604004449 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604004450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604004451 non-specific DNA binding site [nucleotide binding]; other site 713604004452 salt bridge; other site 713604004453 sequence-specific DNA binding site [nucleotide binding]; other site 713604004454 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 713604004455 Domain of unknown function (DUF955); Region: DUF955; pfam06114 713604004456 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 713604004457 isocitrate lyase; Provisional; Region: PRK15063 713604004458 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 713604004459 tetramer interface [polypeptide binding]; other site 713604004460 active site 713604004461 Mg2+/Mn2+ binding site [ion binding]; other site 713604004462 malate synthase A; Region: malate_syn_A; TIGR01344 713604004463 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 713604004464 active site 713604004465 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 713604004466 PA/protease or protease-like domain interface [polypeptide binding]; other site 713604004467 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 713604004468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004470 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 713604004471 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604004472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604004473 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604004474 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604004475 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604004476 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604004477 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 713604004478 catalytic residues [active] 713604004479 dimer interface [polypeptide binding]; other site 713604004480 Uncharacterized conserved protein [Function unknown]; Region: COG1543 713604004481 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 713604004482 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 713604004483 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604004484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604004485 S-adenosylmethionine binding site [chemical binding]; other site 713604004486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 713604004487 EDD domain protein, DegV family; Region: DegV; TIGR00762 713604004488 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 713604004489 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 713604004490 Ligand binding site [chemical binding]; other site 713604004491 Electron transfer flavoprotein domain; Region: ETF; pfam01012 713604004492 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 713604004493 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 713604004494 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 713604004495 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 713604004496 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604004497 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604004498 putative acyl-acceptor binding pocket; other site 713604004499 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604004500 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604004501 putative NAD(P) binding site [chemical binding]; other site 713604004502 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604004503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604004504 DNA binding residues [nucleotide binding] 713604004505 dimerization interface [polypeptide binding]; other site 713604004506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604004507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604004508 putative substrate translocation pore; other site 713604004509 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 713604004510 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 713604004511 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604004512 catalytic residue [active] 713604004513 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 713604004514 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604004515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604004516 Coenzyme A binding pocket [chemical binding]; other site 713604004517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604004518 Coenzyme A binding pocket [chemical binding]; other site 713604004519 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 713604004520 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 713604004521 Scramblase; Region: Scramblase; pfam03803 713604004522 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 713604004523 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 713604004524 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 713604004525 nucleotide binding pocket [chemical binding]; other site 713604004526 K-X-D-G motif; other site 713604004527 catalytic site [active] 713604004528 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 713604004529 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 713604004530 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 713604004531 Dimer interface [polypeptide binding]; other site 713604004532 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604004533 Coenzyme A binding pocket [chemical binding]; other site 713604004534 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 713604004535 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 713604004536 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 713604004537 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 713604004538 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 713604004539 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 713604004540 GatB domain; Region: GatB_Yqey; smart00845 713604004541 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604004542 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604004543 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604004544 Methane oxygenase PmoA; Region: PmoA; pfam14100 713604004545 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604004546 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604004547 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 713604004548 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 713604004549 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604004550 putative ligand binding site [chemical binding]; other site 713604004551 putative NAD binding site [chemical binding]; other site 713604004552 catalytic site [active] 713604004553 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 713604004554 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 713604004555 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 713604004556 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604004557 PYR/PP interface [polypeptide binding]; other site 713604004558 dimer interface [polypeptide binding]; other site 713604004559 TPP binding site [chemical binding]; other site 713604004560 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 713604004561 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 713604004562 TPP-binding site [chemical binding]; other site 713604004563 dimer interface [polypeptide binding]; other site 713604004564 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 713604004565 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 713604004566 putative valine binding site [chemical binding]; other site 713604004567 dimer interface [polypeptide binding]; other site 713604004568 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 713604004569 ketol-acid reductoisomerase; Provisional; Region: PRK05479 713604004570 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 713604004571 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 713604004572 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604004573 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604004574 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604004575 replicative DNA helicase; Provisional; Region: PRK05973 713604004576 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 713604004577 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 713604004578 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 713604004579 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 713604004580 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604004581 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604004582 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604004583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004585 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 713604004586 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 713604004587 ligand binding site [chemical binding]; other site 713604004588 NAD binding site [chemical binding]; other site 713604004589 dimerization interface [polypeptide binding]; other site 713604004590 catalytic site [active] 713604004591 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 713604004592 putative L-serine binding site [chemical binding]; other site 713604004593 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 713604004594 putative active site [active] 713604004595 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 713604004596 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 713604004597 tartrate dehydrogenase; Region: TTC; TIGR02089 713604004598 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 713604004599 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 713604004600 active site 713604004601 catalytic residues [active] 713604004602 metal binding site [ion binding]; metal-binding site 713604004603 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 713604004604 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 713604004605 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604004606 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604004607 hypothetical protein; Provisional; Region: PRK06185 713604004608 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604004609 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 713604004610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604004611 motif II; other site 713604004612 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 713604004613 IHF - DNA interface [nucleotide binding]; other site 713604004614 IHF dimer interface [polypeptide binding]; other site 713604004615 cyclase homology domain; Region: CHD; cd07302 713604004616 nucleotidyl binding site; other site 713604004617 metal binding site [ion binding]; metal-binding site 713604004618 dimer interface [polypeptide binding]; other site 713604004619 NB-ARC domain; Region: NB-ARC; pfam00931 713604004620 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604004623 binding surface 713604004624 TPR motif; other site 713604004625 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604004627 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604004628 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604004629 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 713604004630 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 713604004631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004633 Lsr2; Region: Lsr2; pfam11774 713604004634 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 713604004635 IHF - DNA interface [nucleotide binding]; other site 713604004636 IHF dimer interface [polypeptide binding]; other site 713604004637 HerA helicase [Replication, recombination, and repair]; Region: COG0433 713604004638 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 713604004639 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 713604004640 active site 713604004641 metal binding site [ion binding]; metal-binding site 713604004642 DNA binding site [nucleotide binding] 713604004643 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 713604004644 AAA domain; Region: AAA_23; pfam13476 713604004645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604004646 Walker A/P-loop; other site 713604004647 ATP binding site [chemical binding]; other site 713604004648 Q-loop/lid; other site 713604004649 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 713604004650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604004651 ABC transporter signature motif; other site 713604004652 Walker B; other site 713604004653 D-loop; other site 713604004654 H-loop/switch region; other site 713604004655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 713604004656 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 713604004657 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604004658 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604004659 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604004660 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604004661 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604004662 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604004663 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 713604004664 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 713604004665 substrate binding site [chemical binding]; other site 713604004666 ligand binding site [chemical binding]; other site 713604004667 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 713604004668 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 713604004669 substrate binding site [chemical binding]; other site 713604004670 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 713604004671 IHF - DNA interface [nucleotide binding]; other site 713604004672 IHF dimer interface [polypeptide binding]; other site 713604004673 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 713604004674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 713604004675 NB-ARC domain; Region: NB-ARC; pfam00931 713604004676 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004677 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 713604004678 active site 713604004679 Ap6A binding site [chemical binding]; other site 713604004680 nudix motif; other site 713604004681 metal binding site [ion binding]; metal-binding site 713604004682 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604004683 catalytic core [active] 713604004684 polyphosphate kinase; Provisional; Region: PRK05443 713604004685 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 713604004686 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 713604004687 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 713604004688 putative domain interface [polypeptide binding]; other site 713604004689 putative active site [active] 713604004690 catalytic site [active] 713604004691 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 713604004692 putative domain interface [polypeptide binding]; other site 713604004693 putative active site [active] 713604004694 catalytic site [active] 713604004695 Guanylyl transferase CofC like; Region: CofC; cl17472 713604004696 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604004697 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604004698 putative acyl-acceptor binding pocket; other site 713604004699 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 713604004700 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 713604004701 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 713604004702 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 713604004703 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 713604004704 active site 713604004705 homotetramer interface [polypeptide binding]; other site 713604004706 homodimer interface [polypeptide binding]; other site 713604004707 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604004708 active site 713604004709 ApbE family; Region: ApbE; pfam02424 713604004710 FMN-binding domain; Region: FMN_bind; cl01081 713604004711 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 713604004712 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 713604004713 FAD binding pocket [chemical binding]; other site 713604004714 FAD binding motif [chemical binding]; other site 713604004715 phosphate binding motif [ion binding]; other site 713604004716 beta-alpha-beta structure motif; other site 713604004717 NAD binding pocket [chemical binding]; other site 713604004718 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604004719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604004720 active site 713604004721 phosphorylation site [posttranslational modification] 713604004722 intermolecular recognition site; other site 713604004723 dimerization interface [polypeptide binding]; other site 713604004724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604004725 DNA binding site [nucleotide binding] 713604004726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604004727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604004728 dimer interface [polypeptide binding]; other site 713604004729 phosphorylation site [posttranslational modification] 713604004730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604004731 ATP binding site [chemical binding]; other site 713604004732 Mg2+ binding site [ion binding]; other site 713604004733 G-X-G motif; other site 713604004734 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 713604004735 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604004736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004737 DNA-binding site [nucleotide binding]; DNA binding site 713604004738 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604004739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004740 homodimer interface [polypeptide binding]; other site 713604004741 catalytic residue [active] 713604004742 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 713604004743 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 713604004744 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604004745 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 713604004746 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604004747 AsnC family; Region: AsnC_trans_reg; pfam01037 713604004748 thiamine monophosphate kinase; Provisional; Region: PRK05731 713604004749 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 713604004750 ATP binding site [chemical binding]; other site 713604004751 dimerization interface [polypeptide binding]; other site 713604004752 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 713604004753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604004754 Coenzyme A binding pocket [chemical binding]; other site 713604004755 alpha-galactosidase; Region: PLN02808; cl17638 713604004756 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 713604004757 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 713604004758 trimer interface [polypeptide binding]; other site 713604004759 putative metal binding site [ion binding]; other site 713604004760 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 713604004761 ligand binding site [chemical binding]; other site 713604004762 active site 713604004763 UGI interface [polypeptide binding]; other site 713604004764 catalytic site [active] 713604004765 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604004766 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 713604004767 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 713604004768 DAK2 domain; Region: Dak2; pfam02734 713604004769 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 713604004770 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 713604004771 generic binding surface II; other site 713604004772 ssDNA binding site; other site 713604004773 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604004774 ATP binding site [chemical binding]; other site 713604004775 putative Mg++ binding site [ion binding]; other site 713604004776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604004777 nucleotide binding region [chemical binding]; other site 713604004778 ATP-binding site [chemical binding]; other site 713604004779 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 713604004780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604004781 Coenzyme A binding pocket [chemical binding]; other site 713604004782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004784 Erythromycin esterase; Region: Erythro_esteras; pfam05139 713604004785 Caspase domain; Region: Peptidase_C14; pfam00656 713604004786 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 713604004787 calcium binding site 2 [ion binding]; other site 713604004788 active site 713604004789 catalytic triad [active] 713604004790 calcium binding site 1 [ion binding]; other site 713604004791 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604004792 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 713604004793 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604004794 pyruvate carboxylase; Reviewed; Region: PRK12999 713604004795 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604004796 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604004797 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 713604004798 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 713604004799 active site 713604004800 catalytic residues [active] 713604004801 metal binding site [ion binding]; metal-binding site 713604004802 homodimer binding site [polypeptide binding]; other site 713604004803 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604004804 carboxyltransferase (CT) interaction site; other site 713604004805 biotinylation site [posttranslational modification]; other site 713604004806 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 713604004807 active site 713604004808 Mn binding site [ion binding]; other site 713604004809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004810 DNA-binding site [nucleotide binding]; DNA binding site 713604004811 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604004812 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604004813 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604004814 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604004815 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 713604004816 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604004817 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604004818 mce related protein; Region: MCE; pfam02470 713604004819 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604004820 mce related protein; Region: MCE; pfam02470 713604004821 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604004822 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604004823 mce related protein; Region: MCE; pfam02470 713604004824 mce related protein; Region: MCE; pfam02470 713604004825 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604004826 mce related protein; Region: MCE; pfam02470 713604004827 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604004828 mce related protein; Region: MCE; pfam02470 713604004829 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604004830 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604004831 Permease; Region: Permease; pfam02405 713604004832 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604004833 Permease; Region: Permease; pfam02405 713604004834 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 713604004835 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 713604004836 hypothetical protein; Provisional; Region: PRK08244 713604004837 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604004838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604004839 non-specific DNA binding site [nucleotide binding]; other site 713604004840 salt bridge; other site 713604004841 sequence-specific DNA binding site [nucleotide binding]; other site 713604004842 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 713604004843 structural tetrad; other site 713604004844 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604004845 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 713604004846 structural tetrad; other site 713604004847 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604004848 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 713604004849 Family description; Region: UvrD_C_2; pfam13538 713604004850 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 713604004851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604004852 S-adenosylmethionine binding site [chemical binding]; other site 713604004853 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 713604004854 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 713604004855 active site 713604004856 (T/H)XGH motif; other site 713604004857 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 713604004858 active site 713604004859 barstar interaction site; other site 713604004860 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 713604004861 active site 713604004862 RNA polymerase factor sigma-70; Validated; Region: PRK09047 713604004863 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604004864 DNA binding residues [nucleotide binding] 713604004865 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 713604004866 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 713604004867 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 713604004868 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 713604004869 ribonuclease III; Reviewed; Region: rnc; PRK00102 713604004870 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 713604004871 dimerization interface [polypeptide binding]; other site 713604004872 active site 713604004873 metal binding site [ion binding]; metal-binding site 713604004874 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 713604004875 dsRNA binding site [nucleotide binding]; other site 713604004876 Right handed beta helix region; Region: Beta_helix; pfam13229 713604004877 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 713604004878 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 713604004879 DNA binding site [nucleotide binding] 713604004880 catalytic residue [active] 713604004881 H2TH interface [polypeptide binding]; other site 713604004882 putative catalytic residues [active] 713604004883 turnover-facilitating residue; other site 713604004884 intercalation triad [nucleotide binding]; other site 713604004885 8OG recognition residue [nucleotide binding]; other site 713604004886 putative reading head residues; other site 713604004887 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604004888 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 713604004889 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 713604004890 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604004891 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604004892 Predicted membrane protein [Function unknown]; Region: COG4709 713604004893 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604004894 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604004895 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 713604004896 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 713604004897 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604004898 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 713604004899 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 713604004900 catalytic triad [active] 713604004901 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604004902 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 713604004903 NAD(P) binding site [chemical binding]; other site 713604004904 catalytic residues [active] 713604004905 short chain dehydrogenase; Provisional; Region: PRK06057 713604004906 classical (c) SDRs; Region: SDR_c; cd05233 713604004907 NAD(P) binding site [chemical binding]; other site 713604004908 active site 713604004909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604004910 non-specific DNA binding site [nucleotide binding]; other site 713604004911 salt bridge; other site 713604004912 sequence-specific DNA binding site [nucleotide binding]; other site 713604004913 glycine dehydrogenase; Provisional; Region: PRK05367 713604004914 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 713604004915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004916 tetramer interface [polypeptide binding]; other site 713604004917 catalytic residue [active] 713604004918 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 713604004919 tetramer interface [polypeptide binding]; other site 713604004920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004921 catalytic residue [active] 713604004922 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 713604004923 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 713604004924 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 713604004925 lipoyl attachment site [posttranslational modification]; other site 713604004926 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 713604004927 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 713604004928 dimer interface [polypeptide binding]; other site 713604004929 active site 713604004930 glycine-pyridoxal phosphate binding site [chemical binding]; other site 713604004931 folate binding site [chemical binding]; other site 713604004932 lipoyl synthase; Provisional; Region: PRK05481 713604004933 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604004934 FeS/SAM binding site; other site 713604004935 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 713604004936 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 713604004937 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 713604004938 Protein of unknown function (DUF433); Region: DUF433; cl01030 713604004939 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604004940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004941 DNA-binding site [nucleotide binding]; DNA binding site 713604004942 FCD domain; Region: FCD; pfam07729 713604004943 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 713604004944 Transglycosylase; Region: Transgly; pfam00912 713604004945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604004946 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604004947 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 713604004948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604004949 S-adenosylmethionine binding site [chemical binding]; other site 713604004950 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604004951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004952 DNA-binding site [nucleotide binding]; DNA binding site 713604004953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604004954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004955 homodimer interface [polypeptide binding]; other site 713604004956 catalytic residue [active] 713604004957 hypothetical protein; Provisional; Region: PRK07236 713604004958 Pilus assembly protein, PilP; Region: PilP; pfam04351 713604004959 short chain dehydrogenase; Provisional; Region: PRK07201 713604004960 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 713604004961 putative NAD(P) binding site [chemical binding]; other site 713604004962 active site 713604004963 putative substrate binding site [chemical binding]; other site 713604004964 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 713604004965 classical (c) SDRs; Region: SDR_c; cd05233 713604004966 NAD(P) binding site [chemical binding]; other site 713604004967 NAD binding site [chemical binding]; other site 713604004968 active site 713604004969 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604004970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604004971 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604004972 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604004973 DNA binding residues [nucleotide binding] 713604004974 dimer interface [polypeptide binding]; other site 713604004975 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 713604004976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604004977 putative substrate translocation pore; other site 713604004978 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604004979 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604004980 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604004981 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 713604004982 metal binding site [ion binding]; metal-binding site 713604004983 substrate binding pocket [chemical binding]; other site 713604004984 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 713604004985 classical (c) SDRs; Region: SDR_c; cd05233 713604004986 NAD(P) binding site [chemical binding]; other site 713604004987 active site 713604004988 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 713604004989 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604004990 ligand binding site [chemical binding]; other site 713604004991 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604004992 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604004993 Walker A/P-loop; other site 713604004994 ATP binding site [chemical binding]; other site 713604004995 Q-loop/lid; other site 713604004996 ABC transporter signature motif; other site 713604004997 Walker B; other site 713604004998 D-loop; other site 713604004999 H-loop/switch region; other site 713604005000 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604005001 ABC transporter; Region: ABC_tran; pfam00005 713604005002 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604005003 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604005004 TM-ABC transporter signature motif; other site 713604005005 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604005006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005007 DNA-binding site [nucleotide binding]; DNA binding site 713604005008 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604005009 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604005010 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604005011 active site 713604005012 catalytic tetrad [active] 713604005013 Amidohydrolase; Region: Amidohydro_2; pfam04909 713604005014 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 713604005015 active site 713604005016 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 713604005017 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604005018 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604005019 DNA binding residues [nucleotide binding] 713604005020 Domain of unknown function (DUF202); Region: DUF202; cl09954 713604005021 Domain of unknown function (DUF202); Region: DUF202; cl09954 713604005022 GtrA-like protein; Region: GtrA; pfam04138 713604005023 transcription termination factor Rho; Provisional; Region: PRK12678 713604005024 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 713604005025 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 713604005026 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 713604005027 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 713604005028 dimerization interface [polypeptide binding]; other site 713604005029 ligand binding site [chemical binding]; other site 713604005030 NADP binding site [chemical binding]; other site 713604005031 catalytic site [active] 713604005032 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 713604005033 Melibiase; Region: Melibiase; pfam02065 713604005034 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604005035 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604005036 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604005037 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604005038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604005039 dimer interface [polypeptide binding]; other site 713604005040 conserved gate region; other site 713604005041 ABC-ATPase subunit interface; other site 713604005042 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604005043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604005044 dimer interface [polypeptide binding]; other site 713604005045 conserved gate region; other site 713604005046 putative PBP binding loops; other site 713604005047 ABC-ATPase subunit interface; other site 713604005048 alpha-galactosidase; Region: PLN02808; cl17638 713604005049 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 713604005050 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 713604005051 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 713604005052 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604005053 dimer interface [polypeptide binding]; other site 713604005054 active site 713604005055 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 713604005056 heterodimer interface [polypeptide binding]; other site 713604005057 multimer interface [polypeptide binding]; other site 713604005058 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 713604005059 active site 713604005060 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 713604005061 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 713604005062 heterodimer interface [polypeptide binding]; other site 713604005063 active site 713604005064 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604005065 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604005066 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604005067 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604005068 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 713604005069 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604005070 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604005071 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 713604005072 metal-binding site 713604005073 MoxR-like ATPases [General function prediction only]; Region: COG0714 713604005074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604005075 Walker A motif; other site 713604005076 ATP binding site [chemical binding]; other site 713604005077 Walker B motif; other site 713604005078 arginine finger; other site 713604005079 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 713604005080 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 713604005081 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 713604005082 metal ion-dependent adhesion site (MIDAS); other site 713604005083 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 713604005084 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 713604005085 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 713604005086 XdhC Rossmann domain; Region: XdhC_C; pfam13478 713604005087 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604005088 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604005089 catalytic loop [active] 713604005090 iron binding site [ion binding]; other site 713604005091 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604005092 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 713604005093 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604005094 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604005095 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604005096 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 713604005097 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 713604005098 putative hydrophobic ligand binding site [chemical binding]; other site 713604005099 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604005100 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604005101 metal binding site [ion binding]; metal-binding site 713604005102 active site 713604005103 I-site; other site 713604005104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604005105 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604005106 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604005107 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604005108 active site 713604005109 catalytic tetrad [active] 713604005110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005112 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604005113 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 713604005114 sugar binding site [chemical binding]; other site 713604005115 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604005116 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604005117 active site 713604005118 metal binding site [ion binding]; metal-binding site 713604005119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604005120 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604005121 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 713604005122 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604005123 PYR/PP interface [polypeptide binding]; other site 713604005124 dimer interface [polypeptide binding]; other site 713604005125 TPP binding site [chemical binding]; other site 713604005126 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604005127 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604005128 TPP-binding site [chemical binding]; other site 713604005129 KduI/IolB family; Region: KduI; pfam04962 713604005130 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604005131 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 713604005132 substrate binding site [chemical binding]; other site 713604005133 ATP binding site [chemical binding]; other site 713604005134 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604005135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604005136 Walker A/P-loop; other site 713604005137 ATP binding site [chemical binding]; other site 713604005138 Q-loop/lid; other site 713604005139 ABC transporter signature motif; other site 713604005140 Walker B; other site 713604005141 D-loop; other site 713604005142 H-loop/switch region; other site 713604005143 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604005144 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604005145 TM-ABC transporter signature motif; other site 713604005146 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 713604005147 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604005148 putative ligand binding site [chemical binding]; other site 713604005149 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604005150 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604005151 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604005152 DNA binding site [nucleotide binding] 713604005153 domain linker motif; other site 713604005154 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604005155 dimerization interface [polypeptide binding]; other site 713604005156 ligand binding site [chemical binding]; other site 713604005157 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604005158 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604005159 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604005160 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 713604005161 active site 713604005162 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 713604005163 dimer interface [polypeptide binding]; other site 713604005164 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 713604005165 Ligand Binding Site [chemical binding]; other site 713604005166 Molecular Tunnel; other site 713604005167 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 713604005168 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 713604005169 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604005170 Soluble P-type ATPase [General function prediction only]; Region: COG4087 713604005171 K+-transporting ATPase, c chain; Region: KdpC; cl00944 713604005172 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 713604005173 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 713604005174 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 713604005175 Ligand Binding Site [chemical binding]; other site 713604005176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604005177 dimer interface [polypeptide binding]; other site 713604005178 phosphorylation site [posttranslational modification] 713604005179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604005180 ATP binding site [chemical binding]; other site 713604005181 Mg2+ binding site [ion binding]; other site 713604005182 G-X-G motif; other site 713604005183 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 713604005184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604005185 active site 713604005186 phosphorylation site [posttranslational modification] 713604005187 intermolecular recognition site; other site 713604005188 dimerization interface [polypeptide binding]; other site 713604005189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604005190 DNA binding site [nucleotide binding] 713604005191 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604005192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604005193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005194 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005195 acylphosphatase; Provisional; Region: PRK14422 713604005196 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 713604005197 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 713604005198 Walker A/P-loop; other site 713604005199 ATP binding site [chemical binding]; other site 713604005200 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 713604005201 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 713604005202 ABC transporter signature motif; other site 713604005203 Walker B; other site 713604005204 D-loop; other site 713604005205 H-loop/switch region; other site 713604005206 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 713604005207 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 713604005208 Na binding site [ion binding]; other site 713604005209 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 713604005210 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 713604005211 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 713604005212 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604005213 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604005214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604005215 Coenzyme A binding pocket [chemical binding]; other site 713604005216 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604005217 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604005218 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604005219 malate synthase A; Region: malate_syn_A; TIGR01344 713604005220 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 713604005221 active site 713604005222 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 713604005223 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 713604005224 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604005225 MarR family; Region: MarR_2; pfam12802 713604005226 MarR family; Region: MarR_2; cl17246 713604005227 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 713604005228 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604005229 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 713604005230 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 713604005231 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604005232 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604005233 catalytic loop [active] 713604005234 iron binding site [ion binding]; other site 713604005235 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604005236 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 713604005237 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 713604005238 active site 713604005239 putative substrate binding pocket [chemical binding]; other site 713604005240 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 713604005241 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604005242 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604005243 alpha-galactosidase; Region: PLN02808; cl17638 713604005244 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604005245 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604005246 putative sugar binding sites [chemical binding]; other site 713604005247 Q-X-W motif; other site 713604005248 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005250 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604005251 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604005252 urate oxidase; Region: urate_oxi; TIGR03383 713604005253 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 713604005254 active site 713604005255 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 713604005256 active site 713604005257 homotetramer interface [polypeptide binding]; other site 713604005258 putative OHCU decarboxylase; Provisional; Region: PRK13798 713604005259 Domain of unknown function DUF77; Region: DUF77; cl00307 713604005260 HTH domain; Region: HTH_22; pfam13309 713604005261 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 713604005262 allantoinase; Region: allantoinase; TIGR03178 713604005263 active site 713604005264 allantoicase; Provisional; Region: PRK13257 713604005265 Allantoicase repeat; Region: Allantoicase; pfam03561 713604005266 Allantoicase repeat; Region: Allantoicase; pfam03561 713604005267 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 713604005268 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 713604005269 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 713604005270 homodimer interface [polypeptide binding]; other site 713604005271 substrate-cofactor binding pocket; other site 713604005272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604005273 catalytic residue [active] 713604005274 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 713604005275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005276 NAD(P) binding site [chemical binding]; other site 713604005277 active site 713604005278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604005280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604005281 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604005282 putative dimerization interface [polypeptide binding]; other site 713604005283 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604005284 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604005285 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604005286 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 713604005287 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 713604005288 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 713604005289 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 713604005290 Nitrogen regulatory protein P-II; Region: P-II; smart00938 713604005291 PII uridylyl-transferase; Provisional; Region: PRK03381 713604005292 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 713604005293 metal binding triad; other site 713604005294 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 713604005295 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604005296 Zn2+ binding site [ion binding]; other site 713604005297 Mg2+ binding site [ion binding]; other site 713604005298 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 713604005299 hypothetical protein; Provisional; Region: PRK06834 713604005300 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604005301 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 713604005302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005303 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604005304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604005305 metal binding site [ion binding]; metal-binding site 713604005306 active site 713604005307 I-site; other site 713604005308 short chain dehydrogenase; Provisional; Region: PRK06172 713604005309 classical (c) SDRs; Region: SDR_c; cd05233 713604005310 NAD(P) binding site [chemical binding]; other site 713604005311 active site 713604005312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005314 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 713604005315 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 713604005316 heterodimer interface [polypeptide binding]; other site 713604005317 DNA binding site [nucleotide binding] 713604005318 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604005319 MarR family; Region: MarR_2; cl17246 713604005320 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604005321 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604005322 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 713604005323 Walker A/P-loop; other site 713604005324 ATP binding site [chemical binding]; other site 713604005325 Q-loop/lid; other site 713604005326 ABC transporter signature motif; other site 713604005327 Walker B; other site 713604005328 D-loop; other site 713604005329 H-loop/switch region; other site 713604005330 signal recognition particle protein; Provisional; Region: PRK10867 713604005331 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 713604005332 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 713604005333 P loop; other site 713604005334 GTP binding site [chemical binding]; other site 713604005335 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 713604005336 Signal peptide binding domain; Region: SRP_SPB; pfam02978 713604005337 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604005338 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604005339 active site 713604005340 CAAX protease self-immunity; Region: Abi; pfam02517 713604005341 CAAX protease self-immunity; Region: Abi; pfam02517 713604005342 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 713604005343 hypothetical protein; Provisional; Region: PRK02821 713604005344 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 713604005345 G-X-X-G motif; other site 713604005346 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 713604005347 RimM N-terminal domain; Region: RimM; pfam01782 713604005348 PRC-barrel domain; Region: PRC; pfam05239 713604005349 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 713604005350 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 713604005351 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 713604005352 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 713604005353 Catalytic site [active] 713604005354 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 713604005355 RNA/DNA hybrid binding site [nucleotide binding]; other site 713604005356 active site 713604005357 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 713604005358 hypothetical protein; Reviewed; Region: PRK12497 713604005359 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 713604005360 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 713604005361 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 713604005362 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 713604005363 DNA protecting protein DprA; Region: dprA; TIGR00732 713604005364 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 713604005365 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 713604005366 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604005367 active site 713604005368 DNA binding site [nucleotide binding] 713604005369 Int/Topo IB signature motif; other site 713604005370 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 713604005371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604005372 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604005373 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604005374 DNA binding residues [nucleotide binding] 713604005375 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 713604005376 Peptidase family M23; Region: Peptidase_M23; pfam01551 713604005377 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 713604005378 rRNA interaction site [nucleotide binding]; other site 713604005379 S8 interaction site; other site 713604005380 putative laminin-1 binding site; other site 713604005381 elongation factor Ts; Provisional; Region: tsf; PRK09377 713604005382 UBA/TS-N domain; Region: UBA; pfam00627 713604005383 Elongation factor TS; Region: EF_TS; pfam00889 713604005384 Elongation factor TS; Region: EF_TS; pfam00889 713604005385 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 713604005386 putative nucleotide binding site [chemical binding]; other site 713604005387 uridine monophosphate binding site [chemical binding]; other site 713604005388 homohexameric interface [polypeptide binding]; other site 713604005389 ribosome recycling factor; Reviewed; Region: frr; PRK00083 713604005390 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 713604005391 hinge region; other site 713604005392 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 713604005393 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 713604005394 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604005395 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604005396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604005397 S-adenosylmethionine binding site [chemical binding]; other site 713604005398 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604005399 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604005400 dimerization interface [polypeptide binding]; other site 713604005401 putative DNA binding site [nucleotide binding]; other site 713604005402 putative Zn2+ binding site [ion binding]; other site 713604005403 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 713604005404 putative PBP binding regions; other site 713604005405 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 713604005406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604005407 Walker A/P-loop; other site 713604005408 ATP binding site [chemical binding]; other site 713604005409 Q-loop/lid; other site 713604005410 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 713604005411 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 713604005412 siderophore binding site; other site 713604005413 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604005414 TPP-binding site [chemical binding]; other site 713604005415 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 713604005416 PYR/PP interface [polypeptide binding]; other site 713604005417 dimer interface [polypeptide binding]; other site 713604005418 TPP binding site [chemical binding]; other site 713604005419 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 713604005420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604005421 FeS/SAM binding site; other site 713604005422 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 713604005423 PA14 domain; Region: PA14; cl08459 713604005424 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604005425 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604005426 Creatinine amidohydrolase; Region: Creatininase; pfam02633 713604005427 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604005428 FAD binding domain; Region: FAD_binding_4; pfam01565 713604005429 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604005430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604005431 dimer interface [polypeptide binding]; other site 713604005432 conserved gate region; other site 713604005433 putative PBP binding loops; other site 713604005434 ABC-ATPase subunit interface; other site 713604005435 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604005436 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604005437 Walker A/P-loop; other site 713604005438 ATP binding site [chemical binding]; other site 713604005439 Q-loop/lid; other site 713604005440 ABC transporter signature motif; other site 713604005441 Walker B; other site 713604005442 D-loop; other site 713604005443 H-loop/switch region; other site 713604005444 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 713604005445 cytosine deaminase; Provisional; Region: PRK05985 713604005446 active site 713604005447 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604005448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604005449 non-specific DNA binding site [nucleotide binding]; other site 713604005450 salt bridge; other site 713604005451 sequence-specific DNA binding site [nucleotide binding]; other site 713604005452 Cupin domain; Region: Cupin_2; pfam07883 713604005453 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 713604005454 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 713604005455 FMN-binding pocket [chemical binding]; other site 713604005456 flavin binding motif; other site 713604005457 phosphate binding motif [ion binding]; other site 713604005458 beta-alpha-beta structure motif; other site 713604005459 NAD binding pocket [chemical binding]; other site 713604005460 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604005461 catalytic loop [active] 713604005462 iron binding site [ion binding]; other site 713604005463 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604005464 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 713604005465 active site 713604005466 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 713604005467 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 713604005468 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 713604005469 putative [Fe4-S4] binding site [ion binding]; other site 713604005470 putative molybdopterin cofactor binding site [chemical binding]; other site 713604005471 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 713604005472 putative molybdopterin cofactor binding site; other site 713604005473 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604005474 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604005475 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604005476 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 713604005477 DNA binding residues [nucleotide binding] 713604005478 putative dimer interface [polypeptide binding]; other site 713604005479 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604005480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604005481 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 713604005482 MoaE interaction surface [polypeptide binding]; other site 713604005483 MoeB interaction surface [polypeptide binding]; other site 713604005484 thiocarboxylated glycine; other site 713604005485 VPS10 domain; Region: VPS10; smart00602 713604005486 VPS10 domain; Region: VPS10; smart00602 713604005487 YCII-related domain; Region: YCII; cl00999 713604005488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005489 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604005490 NAD(P) binding site [chemical binding]; other site 713604005491 active site 713604005492 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604005493 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 713604005494 putative NAD(P) binding site [chemical binding]; other site 713604005495 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604005496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604005497 non-specific DNA binding site [nucleotide binding]; other site 713604005498 salt bridge; other site 713604005499 sequence-specific DNA binding site [nucleotide binding]; other site 713604005500 YCII-related domain; Region: YCII; cl00999 713604005501 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604005502 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604005503 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604005504 DNA binding residues [nucleotide binding] 713604005505 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604005506 substrate binding site [chemical binding]; other site 713604005507 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604005508 oxyanion hole (OAH) forming residues; other site 713604005509 trimer interface [polypeptide binding]; other site 713604005510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005512 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 713604005513 ArsC family; Region: ArsC; pfam03960 713604005514 catalytic residues [active] 713604005515 threonine synthase; Validated; Region: PRK08197 713604005516 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 713604005517 homodimer interface [polypeptide binding]; other site 713604005518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604005519 catalytic residue [active] 713604005520 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 713604005521 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 713604005522 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604005523 classical (c) SDRs; Region: SDR_c; cd05233 713604005524 NAD(P) binding site [chemical binding]; other site 713604005525 active site 713604005526 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604005527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604005528 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604005529 dimerization interface [polypeptide binding]; other site 713604005530 substrate binding pocket [chemical binding]; other site 713604005531 Cytochrome P450; Region: p450; cl12078 713604005532 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604005533 Cytochrome P450; Region: p450; cl12078 713604005534 Serine hydrolase; Region: Ser_hydrolase; cl17834 713604005535 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604005536 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604005537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604005538 non-specific DNA binding site [nucleotide binding]; other site 713604005539 salt bridge; other site 713604005540 sequence-specific DNA binding site [nucleotide binding]; other site 713604005541 AAA domain; Region: AAA_22; pfam13401 713604005542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604005543 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604005544 binding surface 713604005545 TPR motif; other site 713604005546 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604005547 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604005548 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604005549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604005550 binding surface 713604005551 TPR motif; other site 713604005552 TPR repeat; Region: TPR_11; pfam13414 713604005553 hypothetical protein; Provisional; Region: PRK08317 713604005554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604005555 S-adenosylmethionine binding site [chemical binding]; other site 713604005556 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604005557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005558 DNA-binding site [nucleotide binding]; DNA binding site 713604005559 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604005560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604005561 homodimer interface [polypeptide binding]; other site 713604005562 catalytic residue [active] 713604005563 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604005564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604005565 putative substrate translocation pore; other site 713604005566 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 713604005567 active site 713604005568 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 713604005569 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 713604005570 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 713604005571 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 713604005572 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 713604005573 RIP metalloprotease RseP; Region: TIGR00054 713604005574 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 713604005575 active site 713604005576 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 713604005577 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 713604005578 putative substrate binding region [chemical binding]; other site 713604005579 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 713604005580 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 713604005581 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 713604005582 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604005583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604005584 S-adenosylmethionine binding site [chemical binding]; other site 713604005585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604005586 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604005587 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 713604005588 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604005589 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 713604005590 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 713604005591 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604005592 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604005593 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 713604005594 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 713604005595 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 713604005596 active site 713604005597 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604005598 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604005599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604005600 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604005601 Walker A/P-loop; other site 713604005602 ATP binding site [chemical binding]; other site 713604005603 Q-loop/lid; other site 713604005604 ABC transporter signature motif; other site 713604005605 Walker B; other site 713604005606 D-loop; other site 713604005607 H-loop/switch region; other site 713604005608 Uncharacterized conserved protein [Function unknown]; Region: COG3595 713604005609 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604005610 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604005611 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005612 DNA-binding site [nucleotide binding]; DNA binding site 713604005613 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604005614 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 713604005615 mycothione reductase; Reviewed; Region: PRK07846 713604005616 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604005617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604005618 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604005619 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 713604005620 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 713604005621 cleavage site 713604005622 active site 713604005623 substrate binding sites [chemical binding]; other site 713604005624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604005625 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 713604005626 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604005627 catalytic residue [active] 713604005628 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 713604005629 DEAD-like helicases superfamily; Region: DEXDc; smart00487 713604005630 ATP binding site [chemical binding]; other site 713604005631 Mg++ binding site [ion binding]; other site 713604005632 motif III; other site 713604005633 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604005634 nucleotide binding region [chemical binding]; other site 713604005635 ATP-binding site [chemical binding]; other site 713604005636 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 713604005637 ATP binding site [chemical binding]; other site 713604005638 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 713604005639 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604005640 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604005641 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604005642 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604005643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604005644 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604005645 dimerization interface [polypeptide binding]; other site 713604005646 substrate binding pocket [chemical binding]; other site 713604005647 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 713604005648 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 713604005649 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604005650 hypothetical protein; Validated; Region: PRK02101 713604005651 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604005652 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 713604005653 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604005654 putative ligand binding site [chemical binding]; other site 713604005655 putative NAD binding site [chemical binding]; other site 713604005656 catalytic site [active] 713604005657 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 713604005658 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604005659 active site 713604005660 prolyl-tRNA synthetase; Provisional; Region: PRK09194 713604005661 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 713604005662 dimer interface [polypeptide binding]; other site 713604005663 motif 1; other site 713604005664 active site 713604005665 motif 2; other site 713604005666 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 713604005667 putative deacylase active site [active] 713604005668 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604005669 active site 713604005670 motif 3; other site 713604005671 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 713604005672 anticodon binding site; other site 713604005673 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 713604005674 Predicted membrane protein [Function unknown]; Region: COG2733 713604005675 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604005676 RHS Repeat; Region: RHS_repeat; pfam05593 713604005677 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604005678 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 713604005679 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 713604005680 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 713604005681 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604005682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604005683 active site 713604005684 phosphorylation site [posttranslational modification] 713604005685 intermolecular recognition site; other site 713604005686 dimerization interface [polypeptide binding]; other site 713604005687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604005688 DNA binding residues [nucleotide binding] 713604005689 Putative sensor; Region: Sensor; pfam13796 713604005690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604005691 Histidine kinase; Region: HisKA_3; pfam07730 713604005692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604005693 ATP binding site [chemical binding]; other site 713604005694 Mg2+ binding site [ion binding]; other site 713604005695 G-X-G motif; other site 713604005696 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 713604005697 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 713604005698 putative di-iron ligands [ion binding]; other site 713604005699 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 713604005700 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 713604005701 FAD binding pocket [chemical binding]; other site 713604005702 FAD binding motif [chemical binding]; other site 713604005703 phosphate binding motif [ion binding]; other site 713604005704 beta-alpha-beta structure motif; other site 713604005705 NAD binding pocket [chemical binding]; other site 713604005706 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604005707 catalytic loop [active] 713604005708 iron binding site [ion binding]; other site 713604005709 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 713604005710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005711 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 713604005712 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 713604005713 ligand binding site [chemical binding]; other site 713604005714 homodimer interface [polypeptide binding]; other site 713604005715 NAD(P) binding site [chemical binding]; other site 713604005716 trimer interface B [polypeptide binding]; other site 713604005717 trimer interface A [polypeptide binding]; other site 713604005718 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 713604005719 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 713604005720 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 713604005721 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 713604005722 Lsr2; Region: Lsr2; pfam11774 713604005723 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 713604005724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604005725 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604005726 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 713604005727 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 713604005728 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 713604005729 dimer interface [polypeptide binding]; other site 713604005730 active site 713604005731 acyl carrier protein; Provisional; Region: acpP; PRK00982 713604005732 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 713604005733 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 713604005734 dimer interface [polypeptide binding]; other site 713604005735 active site 713604005736 CoA binding pocket [chemical binding]; other site 713604005737 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 713604005738 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 713604005739 putative dimer interface [polypeptide binding]; other site 713604005740 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604005741 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604005742 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 713604005743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604005744 Walker A/P-loop; other site 713604005745 ATP binding site [chemical binding]; other site 713604005746 Q-loop/lid; other site 713604005747 ABC transporter signature motif; other site 713604005748 Walker B; other site 713604005749 D-loop; other site 713604005750 H-loop/switch region; other site 713604005751 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 713604005752 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604005753 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 713604005754 L-lactate permease; Region: Lactate_perm; cl00701 713604005755 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 713604005756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005758 short chain dehydrogenase; Provisional; Region: PRK06500 713604005759 classical (c) SDRs; Region: SDR_c; cd05233 713604005760 NAD(P) binding site [chemical binding]; other site 713604005761 active site 713604005762 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 713604005763 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604005764 phosphate binding site [ion binding]; other site 713604005765 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 713604005766 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 713604005767 dimer interface [polypeptide binding]; other site 713604005768 TPP-binding site [chemical binding]; other site 713604005769 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 713604005770 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 713604005771 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 713604005772 dimer interface [polypeptide binding]; other site 713604005773 catalytic triad [active] 713604005774 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 713604005775 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 713604005776 catalytic residues [active] 713604005777 catalytic nucleophile [active] 713604005778 Recombinase; Region: Recombinase; pfam07508 713604005779 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 713604005780 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 713604005781 catalytic residues [active] 713604005782 catalytic nucleophile [active] 713604005783 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 713604005784 DNA methylase; Region: N6_N4_Mtase; pfam01555 713604005785 Replication-relaxation; Region: Replic_Relax; pfam13814 713604005786 AAA-like domain; Region: AAA_10; pfam12846 713604005787 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604005788 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 713604005789 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 713604005790 Zn binding site [ion binding]; other site 713604005791 Immunity protein Imm1; Region: Imm1; pfam14430 713604005792 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 713604005793 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604005794 cleavage site 713604005795 active site 713604005796 substrate binding sites [chemical binding]; other site 713604005797 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 713604005798 catalytic residues [active] 713604005799 catalytic nucleophile [active] 713604005800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604005801 non-specific DNA binding site [nucleotide binding]; other site 713604005802 salt bridge; other site 713604005803 sequence-specific DNA binding site [nucleotide binding]; other site 713604005804 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604005805 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604005806 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 713604005807 active site 713604005808 Zn binding site [ion binding]; other site 713604005809 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 713604005810 ATP binding site [chemical binding]; other site 713604005811 substrate interface [chemical binding]; other site 713604005812 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 713604005813 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604005814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604005815 Domain of unknown function (DUF955); Region: DUF955; pfam06114 713604005816 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 713604005817 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 713604005818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604005819 putative substrate translocation pore; other site 713604005820 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604005821 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604005822 MarR family; Region: MarR_2; pfam12802 713604005823 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604005824 Cupin domain; Region: Cupin_2; pfam07883 713604005825 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604005826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604005827 active site 713604005828 oxidoreductase; Provisional; Region: PRK06196 713604005829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005830 NAD(P) binding site [chemical binding]; other site 713604005831 active site 713604005832 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604005833 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604005834 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604005835 catalytic residue [active] 713604005836 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604005837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005838 DNA-binding site [nucleotide binding]; DNA binding site 713604005839 FCD domain; Region: FCD; pfam07729 713604005840 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 713604005841 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604005842 active site 713604005843 metal binding site [ion binding]; metal-binding site 713604005844 hexamer interface [polypeptide binding]; other site 713604005845 Predicted acyl esterases [General function prediction only]; Region: COG2936 713604005846 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604005847 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 713604005848 Aspartase; Region: Aspartase; cd01357 713604005849 active sites [active] 713604005850 tetramer interface [polypeptide binding]; other site 713604005851 L-asparaginase II; Region: Asparaginase_II; pfam06089 713604005852 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 713604005853 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604005854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005855 DNA-binding site [nucleotide binding]; DNA binding site 713604005856 FCD domain; Region: FCD; pfam07729 713604005857 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 713604005858 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 713604005859 active site 713604005860 PHP Thumb interface [polypeptide binding]; other site 713604005861 metal binding site [ion binding]; metal-binding site 713604005862 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 713604005863 generic binding surface II; other site 713604005864 generic binding surface I; other site 713604005865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604005866 putative substrate translocation pore; other site 713604005867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604005868 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 713604005869 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 713604005870 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 713604005871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 713604005872 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604005873 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 713604005874 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 713604005875 nucleophile elbow; other site 713604005876 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604005877 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 713604005878 lipoyl synthase; Provisional; Region: PRK05481 713604005879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604005880 FeS/SAM binding site; other site 713604005881 short chain dehydrogenase; Provisional; Region: PRK06197 713604005882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005883 NAD(P) binding site [chemical binding]; other site 713604005884 active site 713604005885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005887 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604005888 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604005889 lipoate-protein ligase B; Provisional; Region: PRK14345 713604005890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005891 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 713604005892 NAD(P) binding site [chemical binding]; other site 713604005893 active site 713604005894 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 713604005895 E3 interaction surface; other site 713604005896 lipoyl attachment site [posttranslational modification]; other site 713604005897 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 713604005898 E3 interaction surface; other site 713604005899 lipoyl attachment site [posttranslational modification]; other site 713604005900 e3 binding domain; Region: E3_binding; pfam02817 713604005901 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 713604005902 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 713604005903 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 713604005904 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604005905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604005906 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604005907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604005908 Coenzyme A binding pocket [chemical binding]; other site 713604005909 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 713604005910 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 713604005911 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 713604005912 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 713604005913 multifunctional aminopeptidase A; Provisional; Region: PRK00913 713604005914 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 713604005915 interface (dimer of trimers) [polypeptide binding]; other site 713604005916 Substrate-binding/catalytic site; other site 713604005917 Zn-binding sites [ion binding]; other site 713604005918 Protein of unknown function (DUF402); Region: DUF402; pfam04167 713604005919 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 713604005920 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 713604005921 homodimer interface [polypeptide binding]; other site 713604005922 substrate-cofactor binding pocket; other site 713604005923 catalytic residue [active] 713604005924 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 713604005925 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 713604005926 putative dimer interface [polypeptide binding]; other site 713604005927 active site pocket [active] 713604005928 putative cataytic base [active] 713604005929 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 713604005930 substrate binding site; other site 713604005931 dimer interface; other site 713604005932 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604005933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005934 DNA-binding site [nucleotide binding]; DNA binding site 713604005935 UTRA domain; Region: UTRA; cl17743 713604005936 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 713604005937 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 713604005938 ATP binding site [chemical binding]; other site 713604005939 active site 713604005940 substrate binding site [chemical binding]; other site 713604005941 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604005942 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604005943 active site 713604005944 catalytic tetrad [active] 713604005945 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 713604005946 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 713604005947 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 713604005948 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604005949 substrate binding site [chemical binding]; other site 713604005950 ATP binding site [chemical binding]; other site 713604005951 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 713604005952 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 713604005953 active site 713604005954 dimer interface [polypeptide binding]; other site 713604005955 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 713604005956 Ligand Binding Site [chemical binding]; other site 713604005957 Molecular Tunnel; other site 713604005958 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 713604005959 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 713604005960 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 713604005961 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604005962 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604005963 conserved cys residue [active] 713604005964 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604005965 EamA-like transporter family; Region: EamA; pfam00892 713604005966 EamA-like transporter family; Region: EamA; pfam00892 713604005967 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 713604005968 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 713604005969 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 713604005970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 713604005971 active site 713604005972 phosphorylation site [posttranslational modification] 713604005973 intermolecular recognition site; other site 713604005974 dimerization interface [polypeptide binding]; other site 713604005975 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 713604005976 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 713604005977 Cytochrome c; Region: Cytochrom_C; pfam00034 713604005978 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 713604005979 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 713604005980 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604005981 iron-sulfur cluster [ion binding]; other site 713604005982 [2Fe-2S] cluster binding site [ion binding]; other site 713604005983 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 713604005984 heme bH binding site [chemical binding]; other site 713604005985 Qi binding site; other site 713604005986 intrachain domain interface; other site 713604005987 heme bL binding site [chemical binding]; other site 713604005988 interchain domain interface [polypeptide binding]; other site 713604005989 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 713604005990 Qo binding site; other site 713604005991 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 713604005992 intrachain domain interface; other site 713604005993 Qi binding site; other site 713604005994 Qo binding site; other site 713604005995 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 713604005996 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604005997 AsnC family; Region: AsnC_trans_reg; pfam01037 713604005998 hypothetical protein; Validated; Region: PRK07883 713604005999 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 713604006000 active site 713604006001 catalytic site [active] 713604006002 substrate binding site [chemical binding]; other site 713604006003 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 713604006004 GIY-YIG motif/motif A; other site 713604006005 active site 713604006006 catalytic site [active] 713604006007 putative DNA binding site [nucleotide binding]; other site 713604006008 metal binding site [ion binding]; metal-binding site 713604006009 YacP-like NYN domain; Region: NYN_YacP; cl01491 713604006010 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604006011 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604006012 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604006013 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604006014 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 713604006015 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 713604006016 putative hydrophobic ligand binding site [chemical binding]; other site 713604006017 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604006018 Cytochrome P450; Region: p450; cl12078 713604006019 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604006020 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 713604006021 inhibitor-cofactor binding pocket; inhibition site 713604006022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604006023 catalytic residue [active] 713604006024 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 713604006025 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 713604006026 Sulfate transporter family; Region: Sulfate_transp; pfam00916 713604006027 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 713604006028 active site clefts [active] 713604006029 zinc binding site [ion binding]; other site 713604006030 dimer interface [polypeptide binding]; other site 713604006031 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 713604006032 Sulfate transporter family; Region: Sulfate_transp; pfam00916 713604006033 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 713604006034 active site clefts [active] 713604006035 zinc binding site [ion binding]; other site 713604006036 dimer interface [polypeptide binding]; other site 713604006037 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 713604006038 AAA domain; Region: AAA_26; pfam13500 713604006039 biotin synthase; Validated; Region: PRK06256 713604006040 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604006041 FeS/SAM binding site; other site 713604006042 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 713604006043 Peptidase family M48; Region: Peptidase_M48; cl12018 713604006044 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 713604006045 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604006046 nudix motif; other site 713604006047 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 713604006048 quinolinate synthetase; Provisional; Region: PRK09375 713604006049 L-aspartate oxidase; Provisional; Region: PRK06175 713604006050 L-aspartate oxidase; Provisional; Region: PRK07804 713604006051 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 713604006052 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 713604006053 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 713604006054 dimerization interface [polypeptide binding]; other site 713604006055 active site 713604006056 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604006057 catalytic residues [active] 713604006058 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 713604006059 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 713604006060 Proteins of 100 residues with WXG; Region: WXG100; cl02005 713604006061 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604006062 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604006063 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604006064 acyl-activating enzyme (AAE) consensus motif; other site 713604006065 acyl-activating enzyme (AAE) consensus motif; other site 713604006066 AMP binding site [chemical binding]; other site 713604006067 active site 713604006068 CoA binding site [chemical binding]; other site 713604006069 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604006070 cleavage site 713604006071 active site 713604006072 substrate binding sites [chemical binding]; other site 713604006073 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 713604006074 Septum formation; Region: Septum_form; pfam13845 713604006075 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 713604006076 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604006077 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 713604006078 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604006079 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604006080 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 713604006081 Flagellar FliJ protein; Region: FliJ; pfam02050 713604006082 hypothetical protein; Validated; Region: PRK00153 713604006083 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 713604006084 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 713604006085 Protein of unknown function (DUF690); Region: DUF690; cl04939 713604006086 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604006087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604006088 active site 713604006089 phosphorylation site [posttranslational modification] 713604006090 intermolecular recognition site; other site 713604006091 dimerization interface [polypeptide binding]; other site 713604006092 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604006093 DNA binding residues [nucleotide binding] 713604006094 dimerization interface [polypeptide binding]; other site 713604006095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604006096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604006097 active site 713604006098 phosphorylation site [posttranslational modification] 713604006099 intermolecular recognition site; other site 713604006100 dimerization interface [polypeptide binding]; other site 713604006101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604006102 DNA binding residues [nucleotide binding] 713604006103 dimerization interface [polypeptide binding]; other site 713604006104 Predicted amidohydrolase [General function prediction only]; Region: COG0388 713604006105 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 713604006106 putative active site [active] 713604006107 catalytic triad [active] 713604006108 putative dimer interface [polypeptide binding]; other site 713604006109 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 713604006110 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 713604006111 NAD binding site [chemical binding]; other site 713604006112 dimerization interface [polypeptide binding]; other site 713604006113 product binding site; other site 713604006114 substrate binding site [chemical binding]; other site 713604006115 zinc binding site [ion binding]; other site 713604006116 catalytic residues [active] 713604006117 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 713604006118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604006119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604006120 homodimer interface [polypeptide binding]; other site 713604006121 catalytic residue [active] 713604006122 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 713604006123 putative active site pocket [active] 713604006124 4-fold oligomerization interface [polypeptide binding]; other site 713604006125 metal binding residues [ion binding]; metal-binding site 713604006126 3-fold/trimer interface [polypeptide binding]; other site 713604006127 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 713604006128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604006129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006130 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604006131 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604006132 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 713604006133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006134 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 713604006135 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 713604006136 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 713604006137 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 713604006138 DNA binding residues [nucleotide binding] 713604006139 dimer interface [polypeptide binding]; other site 713604006140 [2Fe-2S] cluster binding site [ion binding]; other site 713604006141 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604006142 TPP-binding site [chemical binding]; other site 713604006143 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 713604006144 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 713604006145 PYR/PP interface [polypeptide binding]; other site 713604006146 dimer interface [polypeptide binding]; other site 713604006147 TPP binding site [chemical binding]; other site 713604006148 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 713604006149 nudix motif; other site 713604006150 NIPSNAP; Region: NIPSNAP; pfam07978 713604006151 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006152 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006153 active site 713604006154 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 713604006155 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 713604006156 putative active site [active] 713604006157 oxyanion strand; other site 713604006158 catalytic triad [active] 713604006159 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 713604006160 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 713604006161 catalytic residues [active] 713604006162 classical (c) SDRs; Region: SDR_c; cd05233 713604006163 NAD(P) binding site [chemical binding]; other site 713604006164 active site 713604006165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604006166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006167 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 713604006168 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 713604006169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604006170 Coenzyme A binding pocket [chemical binding]; other site 713604006171 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 713604006172 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 713604006173 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 713604006174 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604006175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604006176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604006177 DNA binding residues [nucleotide binding] 713604006178 Phytase; Region: Phytase; cl17685 713604006179 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 713604006180 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 713604006181 substrate binding site [chemical binding]; other site 713604006182 glutamase interaction surface [polypeptide binding]; other site 713604006183 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 713604006184 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 713604006185 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604006186 short chain dehydrogenase; Provisional; Region: PRK06101 713604006187 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 713604006188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604006189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006190 anthranilate synthase component I; Provisional; Region: PRK13571 713604006191 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 713604006192 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 713604006193 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 713604006194 active site 713604006195 ribulose/triose binding site [chemical binding]; other site 713604006196 phosphate binding site [ion binding]; other site 713604006197 substrate (anthranilate) binding pocket [chemical binding]; other site 713604006198 product (indole) binding pocket [chemical binding]; other site 713604006199 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 713604006200 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 713604006201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604006202 catalytic residue [active] 713604006203 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 713604006204 substrate binding site [chemical binding]; other site 713604006205 active site 713604006206 catalytic residues [active] 713604006207 heterodimer interface [polypeptide binding]; other site 713604006208 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604006209 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 713604006210 DNA binding residues [nucleotide binding] 713604006211 putative dimer interface [polypeptide binding]; other site 713604006212 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 713604006213 putative active site [active] 713604006214 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 713604006215 amidase catalytic site [active] 713604006216 Zn binding residues [ion binding]; other site 713604006217 substrate binding site [chemical binding]; other site 713604006218 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 713604006219 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604006220 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 713604006221 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604006222 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 713604006223 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 713604006224 metal binding site [ion binding]; metal-binding site 713604006225 dimer interface [polypeptide binding]; other site 713604006226 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 713604006227 short chain dehydrogenase; Provisional; Region: PRK07814 713604006228 classical (c) SDRs; Region: SDR_c; cd05233 713604006229 NAD(P) binding site [chemical binding]; other site 713604006230 active site 713604006231 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 713604006232 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 713604006233 active site 713604006234 dimer interface [polypeptide binding]; other site 713604006235 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 713604006236 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 713604006237 active site 713604006238 FMN binding site [chemical binding]; other site 713604006239 substrate binding site [chemical binding]; other site 713604006240 3Fe-4S cluster binding site [ion binding]; other site 713604006241 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 713604006242 domain interface; other site 713604006243 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 713604006244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604006245 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 713604006246 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604006247 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 713604006248 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 713604006249 classical (c) SDRs; Region: SDR_c; cd05233 713604006250 NAD(P) binding site [chemical binding]; other site 713604006251 active site 713604006252 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604006253 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604006254 salt bridge; other site 713604006255 non-specific DNA binding site [nucleotide binding]; other site 713604006256 sequence-specific DNA binding site [nucleotide binding]; other site 713604006257 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 713604006258 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 713604006259 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 713604006260 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604006261 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604006262 active site 713604006263 ATP binding site [chemical binding]; other site 713604006264 substrate binding site [chemical binding]; other site 713604006265 activation loop (A-loop); other site 713604006266 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604006267 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604006268 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604006269 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604006270 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604006271 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604006272 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 713604006273 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604006274 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 713604006275 active site lid residues [active] 713604006276 substrate binding pocket [chemical binding]; other site 713604006277 catalytic residues [active] 713604006278 substrate-Mg2+ binding site; other site 713604006279 aspartate-rich region 1; other site 713604006280 aspartate-rich region 2; other site 713604006281 phytoene desaturase; Region: crtI_fam; TIGR02734 713604006282 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604006283 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 713604006284 substrate binding pocket [chemical binding]; other site 713604006285 chain length determination region; other site 713604006286 substrate-Mg2+ binding site; other site 713604006287 catalytic residues [active] 713604006288 aspartate-rich region 1; other site 713604006289 active site lid residues [active] 713604006290 aspartate-rich region 2; other site 713604006291 Alkylmercury lyase; Region: MerB; pfam03243 713604006292 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 713604006293 FAD binding site [chemical binding]; other site 713604006294 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 713604006295 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 713604006296 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 713604006297 putative deacylase active site [active] 713604006298 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604006299 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604006300 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 713604006301 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604006302 Coenzyme A binding pocket [chemical binding]; other site 713604006303 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 713604006304 active site 713604006305 catalytic residues [active] 713604006306 metal binding site [ion binding]; metal-binding site 713604006307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604006308 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 713604006309 ATP binding site [chemical binding]; other site 713604006310 putative Mg++ binding site [ion binding]; other site 713604006311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604006312 nucleotide binding region [chemical binding]; other site 713604006313 ATP-binding site [chemical binding]; other site 713604006314 DEAD/H associated; Region: DEAD_assoc; pfam08494 713604006315 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604006316 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604006317 putative DNA binding site [nucleotide binding]; other site 713604006318 putative Zn2+ binding site [ion binding]; other site 713604006319 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604006320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006321 D-galactonate transporter; Region: 2A0114; TIGR00893 713604006322 putative substrate translocation pore; other site 713604006323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006324 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 713604006325 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 713604006326 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 713604006327 rod-share determining protein MreBH; Provisional; Region: PRK13929 713604006328 nucleotide binding site [chemical binding]; other site 713604006329 putative NEF/HSP70 interaction site [polypeptide binding]; other site 713604006330 SBD interface [polypeptide binding]; other site 713604006331 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 713604006332 recombinase A; Provisional; Region: recA; PRK09354 713604006333 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 713604006334 hexamer interface [polypeptide binding]; other site 713604006335 Walker A motif; other site 713604006336 ATP binding site [chemical binding]; other site 713604006337 Walker B motif; other site 713604006338 recombination regulator RecX; Reviewed; Region: recX; PRK00117 713604006339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006340 putative substrate translocation pore; other site 713604006341 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 713604006342 active site 713604006343 intersubunit interface [polypeptide binding]; other site 713604006344 catalytic residue [active] 713604006345 phosphogluconate dehydratase; Validated; Region: PRK09054 713604006346 6-phosphogluconate dehydratase; Region: edd; TIGR01196 713604006347 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 713604006348 L-aspartate oxidase; Provisional; Region: PRK06175 713604006349 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 713604006350 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 713604006351 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604006352 catalytic loop [active] 713604006353 iron binding site [ion binding]; other site 713604006354 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 713604006355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604006356 Coenzyme A binding pocket [chemical binding]; other site 713604006357 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604006358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604006359 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604006360 non-specific DNA binding site [nucleotide binding]; other site 713604006361 salt bridge; other site 713604006362 sequence-specific DNA binding site [nucleotide binding]; other site 713604006363 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 713604006364 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 713604006365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604006366 NAD(P) binding site [chemical binding]; other site 713604006367 active site 713604006368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604006369 dimer interface [polypeptide binding]; other site 713604006370 conserved gate region; other site 713604006371 putative PBP binding loops; other site 713604006372 ABC-ATPase subunit interface; other site 713604006373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604006374 dimer interface [polypeptide binding]; other site 713604006375 conserved gate region; other site 713604006376 putative PBP binding loops; other site 713604006377 ABC-ATPase subunit interface; other site 713604006378 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604006379 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604006380 substrate binding pocket [chemical binding]; other site 713604006381 membrane-bound complex binding site; other site 713604006382 hinge residues; other site 713604006383 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 713604006384 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 713604006385 Walker A/P-loop; other site 713604006386 ATP binding site [chemical binding]; other site 713604006387 Q-loop/lid; other site 713604006388 ABC transporter signature motif; other site 713604006389 Walker B; other site 713604006390 D-loop; other site 713604006391 H-loop/switch region; other site 713604006392 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604006393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604006394 active site 713604006395 phosphorylation site [posttranslational modification] 713604006396 intermolecular recognition site; other site 713604006397 dimerization interface [polypeptide binding]; other site 713604006398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604006399 DNA binding site [nucleotide binding] 713604006400 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 713604006401 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604006402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604006403 dimer interface [polypeptide binding]; other site 713604006404 phosphorylation site [posttranslational modification] 713604006405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604006406 ATP binding site [chemical binding]; other site 713604006407 Mg2+ binding site [ion binding]; other site 713604006408 G-X-G motif; other site 713604006409 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 713604006410 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 713604006411 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604006412 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604006413 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 713604006414 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 713604006415 active site 713604006416 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 713604006417 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 713604006418 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 713604006419 putative catalytic site [active] 713604006420 putative metal binding site [ion binding]; other site 713604006421 putative phosphate binding site [ion binding]; other site 713604006422 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 713604006423 putative sugar binding site [chemical binding]; other site 713604006424 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604006425 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 713604006426 active site 713604006427 ATP binding site [chemical binding]; other site 713604006428 substrate binding site [chemical binding]; other site 713604006429 activation loop (A-loop); other site 713604006430 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 713604006431 active site 713604006432 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604006433 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604006434 putative sugar binding sites [chemical binding]; other site 713604006435 Q-X-W motif; other site 713604006436 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604006437 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 713604006438 hypothetical protein; Provisional; Region: PRK07236 713604006439 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604006440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006441 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604006442 hypothetical protein; Provisional; Region: PRK06753 713604006443 hypothetical protein; Provisional; Region: PRK07236 713604006444 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 713604006445 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 713604006446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604006447 FeS/SAM binding site; other site 713604006448 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 713604006449 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 713604006450 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 713604006451 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 713604006452 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 713604006453 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 713604006454 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 713604006455 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 713604006456 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 713604006457 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604006458 active site 713604006459 HIGH motif; other site 713604006460 nucleotide binding site [chemical binding]; other site 713604006461 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604006462 active site 713604006463 KMSKS motif; other site 713604006464 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 713604006465 tRNA binding surface [nucleotide binding]; other site 713604006466 anticodon binding site; other site 713604006467 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604006468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006469 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604006470 putative DNA binding site [nucleotide binding]; other site 713604006471 putative Zn2+ binding site [ion binding]; other site 713604006472 GTPases [General function prediction only]; Region: HflX; COG2262 713604006473 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 713604006474 HflX GTPase family; Region: HflX; cd01878 713604006475 G1 box; other site 713604006476 GTP/Mg2+ binding site [chemical binding]; other site 713604006477 Switch I region; other site 713604006478 G2 box; other site 713604006479 G3 box; other site 713604006480 Switch II region; other site 713604006481 G4 box; other site 713604006482 G5 box; other site 713604006483 LexA repressor; Validated; Region: PRK00215 713604006484 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 713604006485 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 713604006486 Catalytic site [active] 713604006487 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 713604006488 ATP cone domain; Region: ATP-cone; pfam03477 713604006489 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 713604006490 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 713604006491 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 713604006492 active site 713604006493 dimer interface [polypeptide binding]; other site 713604006494 effector binding site; other site 713604006495 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 713604006496 TSCPD domain; Region: TSCPD; pfam12637 713604006497 NB-ARC domain; Region: NB-ARC; pfam00931 713604006498 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 713604006499 dinuclear metal binding motif [ion binding]; other site 713604006500 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 713604006501 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 713604006502 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 713604006503 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604006504 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604006505 TIGR03086 family protein; Region: TIGR03086 713604006506 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604006507 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604006508 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604006509 DNA-binding site [nucleotide binding]; DNA binding site 713604006510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604006511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604006512 homodimer interface [polypeptide binding]; other site 713604006513 catalytic residue [active] 713604006514 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 713604006515 conserved hypothetical protein; Region: TIGR02231 713604006516 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 713604006517 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 713604006518 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 713604006519 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604006520 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 713604006521 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 713604006522 putative active site [active] 713604006523 FAD binding domain; Region: FAD_binding_4; pfam01565 713604006524 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604006525 Berberine and berberine like; Region: BBE; pfam08031 713604006526 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604006527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604006528 active site 713604006529 phosphorylation site [posttranslational modification] 713604006530 intermolecular recognition site; other site 713604006531 dimerization interface [polypeptide binding]; other site 713604006532 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604006533 DNA binding residues [nucleotide binding] 713604006534 dimerization interface [polypeptide binding]; other site 713604006535 Histidine kinase; Region: HisKA_3; pfam07730 713604006536 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604006537 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 713604006538 Peptidase family M23; Region: Peptidase_M23; pfam01551 713604006539 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 713604006540 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 713604006541 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 713604006542 NAD binding site [chemical binding]; other site 713604006543 homodimer interface [polypeptide binding]; other site 713604006544 active site 713604006545 substrate binding site [chemical binding]; other site 713604006546 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 713604006547 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 713604006548 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 713604006549 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 713604006550 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 713604006551 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 713604006552 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 713604006553 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 713604006554 active site residue [active] 713604006555 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 713604006556 active site residue [active] 713604006557 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 713604006558 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 713604006559 active site 713604006560 Zn binding site [ion binding]; other site 713604006561 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604006562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604006563 Coenzyme A binding pocket [chemical binding]; other site 713604006564 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 713604006565 CoA binding domain; Region: CoA_binding_2; pfam13380 713604006566 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 713604006567 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 713604006568 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604006569 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604006570 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006571 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604006572 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006573 active site 713604006574 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006575 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 713604006576 FAD binding site [chemical binding]; other site 713604006577 substrate binding site [chemical binding]; other site 713604006578 catalytic base [active] 713604006579 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604006580 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 713604006581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604006582 NAD(P) binding site [chemical binding]; other site 713604006583 active site 713604006584 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604006585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604006586 NAD(P) binding site [chemical binding]; other site 713604006587 active site 713604006588 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604006589 Permease; Region: Permease; pfam02405 713604006590 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604006591 Permease; Region: Permease; pfam02405 713604006592 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006593 mce related protein; Region: MCE; pfam02470 713604006594 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604006595 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006596 mce related protein; Region: MCE; pfam02470 713604006597 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006598 mce related protein; Region: MCE; pfam02470 713604006599 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006600 mce related protein; Region: MCE; pfam02470 713604006601 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006602 mce related protein; Region: MCE; pfam02470 713604006603 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604006604 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006605 mce related protein; Region: MCE; pfam02470 713604006606 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 713604006607 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604006608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604006609 homodimer interface [polypeptide binding]; other site 713604006610 catalytic residue [active] 713604006611 Ferritin-like domain; Region: Ferritin_2; pfam13668 713604006612 hypothetical protein; Provisional; Region: PRK07236 713604006613 hypothetical protein; Provisional; Region: PRK06847 713604006614 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604006615 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604006616 DNA binding site [nucleotide binding] 713604006617 domain linker motif; other site 713604006618 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604006619 ligand binding site [chemical binding]; other site 713604006620 dimerization interface [polypeptide binding]; other site 713604006621 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604006622 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604006623 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604006624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604006625 dimer interface [polypeptide binding]; other site 713604006626 putative PBP binding loops; other site 713604006627 ABC-ATPase subunit interface; other site 713604006628 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604006629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604006630 dimer interface [polypeptide binding]; other site 713604006631 conserved gate region; other site 713604006632 putative PBP binding loops; other site 713604006633 ABC-ATPase subunit interface; other site 713604006634 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604006635 beta-galactosidase; Region: BGL; TIGR03356 713604006636 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 713604006637 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 713604006638 acyl-activating enzyme (AAE) consensus motif; other site 713604006639 putative AMP binding site [chemical binding]; other site 713604006640 putative active site [active] 713604006641 putative CoA binding site [chemical binding]; other site 713604006642 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604006643 active site 713604006644 metal binding site [ion binding]; metal-binding site 713604006645 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 713604006646 putative hydrophobic ligand binding site [chemical binding]; other site 713604006647 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 713604006648 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 713604006649 DTAP/Switch II; other site 713604006650 Switch I; other site 713604006651 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 713604006652 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604006653 nucleotide binding site [chemical binding]; other site 713604006654 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604006655 nudix motif; other site 713604006656 YacP-like NYN domain; Region: NYN_YacP; cl01491 713604006657 carboxylate-amine ligase; Provisional; Region: PRK13517 713604006658 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 713604006659 Esterase/lipase [General function prediction only]; Region: COG1647 713604006660 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604006661 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604006662 putative acyl-acceptor binding pocket; other site 713604006663 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 713604006664 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 713604006665 phosphofructokinase; Region: PFK_mixed; TIGR02483 713604006666 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 713604006667 active site 713604006668 ADP/pyrophosphate binding site [chemical binding]; other site 713604006669 dimerization interface [polypeptide binding]; other site 713604006670 allosteric effector site; other site 713604006671 fructose-1,6-bisphosphate binding site; other site 713604006672 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604006673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604006674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604006675 DNA binding residues [nucleotide binding] 713604006676 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 713604006677 active sites [active] 713604006678 tetramer interface [polypeptide binding]; other site 713604006679 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 713604006680 apolar tunnel; other site 713604006681 heme binding site [chemical binding]; other site 713604006682 dimerization interface [polypeptide binding]; other site 713604006683 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604006684 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604006685 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604006686 dimerization interface [polypeptide binding]; other site 713604006687 putative DNA binding site [nucleotide binding]; other site 713604006688 putative Zn2+ binding site [ion binding]; other site 713604006689 Glyco_18 domain; Region: Glyco_18; smart00636 713604006690 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 713604006691 active site 713604006692 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 713604006693 pyruvate kinase; Provisional; Region: PRK06247 713604006694 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 713604006695 domain interfaces; other site 713604006696 active site 713604006697 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 713604006698 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 713604006699 active site 713604006700 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 713604006701 catalytic triad [active] 713604006702 dimer interface [polypeptide binding]; other site 713604006703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604006704 non-specific DNA binding site [nucleotide binding]; other site 713604006705 sequence-specific DNA binding site [nucleotide binding]; other site 713604006706 salt bridge; other site 713604006707 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604006708 Predicted ATPase [General function prediction only]; Region: COG3899 713604006709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604006710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604006711 DNA binding residues [nucleotide binding] 713604006712 dimerization interface [polypeptide binding]; other site 713604006713 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 713604006714 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 713604006715 NAD(P) binding site [chemical binding]; other site 713604006716 catalytic residues [active] 713604006717 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 713604006718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006719 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006720 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006721 active site 713604006722 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604006723 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604006724 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604006725 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604006726 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604006727 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604006728 substrate binding site [chemical binding]; other site 713604006729 oxyanion hole (OAH) forming residues; other site 713604006730 trimer interface [polypeptide binding]; other site 713604006731 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 713604006732 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604006733 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604006734 Glucitol operon activator protein (GutM); Region: GutM; cl01890 713604006735 integral membrane protein; Region: integ_memb_HG; TIGR03954 713604006736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006737 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604006738 putative substrate translocation pore; other site 713604006739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604006740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006741 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 713604006742 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 713604006743 Na binding site [ion binding]; other site 713604006744 Protein of unknown function, DUF485; Region: DUF485; pfam04341 713604006745 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604006746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604006747 ATP binding site [chemical binding]; other site 713604006748 Mg2+ binding site [ion binding]; other site 713604006749 G-X-G motif; other site 713604006750 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604006751 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604006752 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604006753 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604006754 G1 box; other site 713604006755 GTP/Mg2+ binding site [chemical binding]; other site 713604006756 G2 box; other site 713604006757 Switch I region; other site 713604006758 G3 box; other site 713604006759 Switch II region; other site 713604006760 G4 box; other site 713604006761 G5 box; other site 713604006762 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 713604006763 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 713604006764 putative hydrophobic ligand binding site [chemical binding]; other site 713604006765 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604006766 dimerization interface [polypeptide binding]; other site 713604006767 putative DNA binding site [nucleotide binding]; other site 713604006768 putative Zn2+ binding site [ion binding]; other site 713604006769 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 713604006770 B12 binding site [chemical binding]; other site 713604006771 cobalt ligand [ion binding]; other site 713604006772 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 713604006773 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604006774 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 713604006775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604006776 S-adenosylmethionine binding site [chemical binding]; other site 713604006777 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604006778 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604006779 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604006780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604006782 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006783 active site 713604006784 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006785 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006786 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006787 active site 713604006788 SNF2 Helicase protein; Region: DUF3670; pfam12419 713604006789 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 713604006790 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604006791 ATP binding site [chemical binding]; other site 713604006792 putative Mg++ binding site [ion binding]; other site 713604006793 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 713604006794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604006795 nucleotide binding region [chemical binding]; other site 713604006796 ATP-binding site [chemical binding]; other site 713604006797 Uncharacterized conserved protein [Function unknown]; Region: COG4279 713604006798 SWIM zinc finger; Region: SWIM; pfam04434 713604006799 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604006800 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604006801 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604006802 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 713604006803 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 713604006804 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604006805 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604006806 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006807 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006808 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006809 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006810 active site 713604006811 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 713604006812 active site 713604006813 catalytic site [active] 713604006814 DUF35 OB-fold domain; Region: DUF35; pfam01796 713604006815 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604006816 active site 2 [active] 713604006817 active site 1 [active] 713604006818 lipid-transfer protein; Provisional; Region: PRK07855 713604006819 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604006820 active site 713604006821 Riboflavin kinase; Region: Flavokinase; smart00904 713604006822 enoyl-CoA hydratase; Region: PLN02864 713604006823 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 713604006824 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 713604006825 dimer interaction site [polypeptide binding]; other site 713604006826 substrate-binding tunnel; other site 713604006827 active site 713604006828 catalytic site [active] 713604006829 substrate binding site [chemical binding]; other site 713604006830 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 713604006831 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 713604006832 FAD binding pocket [chemical binding]; other site 713604006833 FAD binding motif [chemical binding]; other site 713604006834 phosphate binding motif [ion binding]; other site 713604006835 beta-alpha-beta structure motif; other site 713604006836 NAD(p) ribose binding residues [chemical binding]; other site 713604006837 NAD binding pocket [chemical binding]; other site 713604006838 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 713604006839 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604006840 catalytic loop [active] 713604006841 iron binding site [ion binding]; other site 713604006842 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 713604006843 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 713604006844 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 713604006845 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604006846 hypothetical protein; Validated; Region: PRK07121 713604006847 Predicted oxidoreductase [General function prediction only]; Region: COG3573 713604006848 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006849 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 713604006850 Flavin binding site [chemical binding]; other site 713604006851 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 713604006852 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604006853 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 713604006854 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 713604006855 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 713604006856 active site 713604006857 Fe binding site [ion binding]; other site 713604006858 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 713604006859 Smr domain; Region: Smr; pfam01713 713604006860 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604006861 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 713604006862 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604006863 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 713604006864 putative di-iron ligands [ion binding]; other site 713604006865 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 713604006866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604006867 Walker A/P-loop; other site 713604006868 ATP binding site [chemical binding]; other site 713604006869 Q-loop/lid; other site 713604006870 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 713604006871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604006872 Walker A/P-loop; other site 713604006873 ATP binding site [chemical binding]; other site 713604006874 Q-loop/lid; other site 713604006875 ABC transporter signature motif; other site 713604006876 Walker B; other site 713604006877 D-loop; other site 713604006878 H-loop/switch region; other site 713604006879 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604006880 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 713604006881 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604006882 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604006883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604006884 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604006885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604006886 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 713604006887 putative substrate binding pocket [chemical binding]; other site 713604006888 putative dimerization interface [polypeptide binding]; other site 713604006889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604006891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604006892 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604006893 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604006894 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 713604006895 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 713604006896 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006897 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006898 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604006899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604006900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604006901 DNA binding residues [nucleotide binding] 713604006902 Putative zinc-finger; Region: zf-HC2; pfam13490 713604006903 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604006904 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604006905 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006906 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006907 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006908 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006909 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 713604006910 amidohydrolase; Region: amidohydrolases; TIGR01891 713604006911 metal binding site [ion binding]; metal-binding site 713604006912 dimer interface [polypeptide binding]; other site 713604006913 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604006914 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604006915 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 713604006916 active site 713604006917 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604006918 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604006919 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 713604006920 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604006921 dimer interface [polypeptide binding]; other site 713604006922 active site 713604006923 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604006924 Cytochrome P450; Region: p450; cl12078 713604006925 Dienelactone hydrolase family; Region: DLH; pfam01738 713604006926 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 713604006927 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 713604006928 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 713604006929 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 713604006930 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604006931 active site 713604006932 lipid-transfer protein; Provisional; Region: PRK07937 713604006933 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604006934 active site 713604006935 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 713604006936 DUF35 OB-fold domain; Region: DUF35; pfam01796 713604006937 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 713604006938 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 713604006939 DUF35 OB-fold domain; Region: DUF35; pfam01796 713604006940 enoyl-CoA hydratase; Provisional; Region: PRK07799 713604006941 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604006942 substrate binding site [chemical binding]; other site 713604006943 oxyanion hole (OAH) forming residues; other site 713604006944 trimer interface [polypeptide binding]; other site 713604006945 acyl-CoA synthetase; Validated; Region: PRK07798 713604006946 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604006947 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 713604006948 acyl-activating enzyme (AAE) consensus motif; other site 713604006949 acyl-activating enzyme (AAE) consensus motif; other site 713604006950 putative AMP binding site [chemical binding]; other site 713604006951 putative active site [active] 713604006952 putative CoA binding site [chemical binding]; other site 713604006953 Nitronate monooxygenase; Region: NMO; pfam03060 713604006954 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 713604006955 FMN binding site [chemical binding]; other site 713604006956 substrate binding site [chemical binding]; other site 713604006957 putative catalytic residue [active] 713604006958 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 713604006959 cleavage site 713604006960 active site 713604006961 substrate binding sites [chemical binding]; other site 713604006962 amino acid transporter; Region: 2A0306; TIGR00909 713604006963 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604006964 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604006965 DNA-binding site [nucleotide binding]; DNA binding site 713604006966 UTRA domain; Region: UTRA; pfam07702 713604006967 fumarate hydratase; Provisional; Region: PRK15389 713604006968 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 713604006969 Fumarase C-terminus; Region: Fumerase_C; pfam05683 713604006970 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 713604006971 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 713604006972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604006973 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604006974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604006975 DNA binding residues [nucleotide binding] 713604006976 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 713604006977 dimerization interface [polypeptide binding]; other site 713604006978 putative tRNAtyr binding site [nucleotide binding]; other site 713604006979 putative active site [active] 713604006980 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 713604006981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604006982 S-adenosylmethionine binding site [chemical binding]; other site 713604006983 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 713604006984 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 713604006985 metal binding site [ion binding]; metal-binding site 713604006986 putative dimer interface [polypeptide binding]; other site 713604006987 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 713604006988 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604006989 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 713604006990 substrate binding site [chemical binding]; other site 713604006991 ATP binding site [chemical binding]; other site 713604006992 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 713604006993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 713604006994 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 713604006995 SpoOM protein; Region: Spo0M; pfam07070 713604006996 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 713604006997 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 713604006998 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 713604006999 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 713604007000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604007001 ATP binding site [chemical binding]; other site 713604007002 putative Mg++ binding site [ion binding]; other site 713604007003 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 713604007004 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 713604007005 putative ligand binding site [chemical binding]; other site 713604007006 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604007007 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604007008 Walker A/P-loop; other site 713604007009 ATP binding site [chemical binding]; other site 713604007010 Q-loop/lid; other site 713604007011 ABC transporter signature motif; other site 713604007012 Walker B; other site 713604007013 D-loop; other site 713604007014 H-loop/switch region; other site 713604007015 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 713604007016 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604007017 TM-ABC transporter signature motif; other site 713604007018 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604007019 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604007020 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 713604007021 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604007022 amino acid transporter; Region: 2A0306; TIGR00909 713604007023 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 713604007024 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 713604007025 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 713604007026 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 713604007027 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 713604007028 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 713604007029 active site 713604007030 catalytic site [active] 713604007031 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 713604007032 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 713604007033 active site 713604007034 catalytic site [active] 713604007035 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 713604007036 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 713604007037 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 713604007038 catalytic site [active] 713604007039 active site 713604007040 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 713604007041 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 713604007042 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 713604007043 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 713604007044 active site 713604007045 catalytic site [active] 713604007046 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 713604007047 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 713604007048 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 713604007049 active site 713604007050 catalytic site [active] 713604007051 trehalose synthase; Region: treS_nterm; TIGR02456 713604007052 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 713604007053 active site 713604007054 catalytic site [active] 713604007055 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 713604007056 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 713604007057 glycogen branching enzyme; Provisional; Region: PRK05402 713604007058 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 713604007059 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 713604007060 active site 713604007061 catalytic site [active] 713604007062 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 713604007063 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 713604007064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604007065 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604007066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604007067 DNA binding residues [nucleotide binding] 713604007068 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604007069 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604007070 nucleotide binding site [chemical binding]; other site 713604007071 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 713604007072 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 713604007073 active site 713604007074 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 713604007075 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 713604007076 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 713604007077 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 713604007078 trimer interface [polypeptide binding]; other site 713604007079 active site 713604007080 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 713604007081 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 713604007082 generic binding surface II; other site 713604007083 ssDNA binding site; other site 713604007084 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 713604007085 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 713604007086 TrkA-N domain; Region: TrkA_N; pfam02254 713604007087 TrkA-C domain; Region: TrkA_C; pfam02080 713604007088 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 713604007089 TrkA-N domain; Region: TrkA_N; pfam02254 713604007090 TrkA-C domain; Region: TrkA_C; pfam02080 713604007091 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 713604007092 K+ potassium transporter; Region: K_trans; cl15781 713604007093 TRAM domain; Region: TRAM; pfam01938 713604007094 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 713604007095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604007096 S-adenosylmethionine binding site [chemical binding]; other site 713604007097 TIGR03086 family protein; Region: TIGR03086 713604007098 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604007099 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604007100 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 713604007101 NAD(P) binding site [chemical binding]; other site 713604007102 catalytic residues [active] 713604007103 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 713604007104 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 713604007105 TPP-binding site; other site 713604007106 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 713604007107 PYR/PP interface [polypeptide binding]; other site 713604007108 dimer interface [polypeptide binding]; other site 713604007109 TPP binding site [chemical binding]; other site 713604007110 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604007111 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604007112 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604007113 DNA binding site [nucleotide binding] 713604007114 domain linker motif; other site 713604007115 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604007116 ligand binding site [chemical binding]; other site 713604007117 dimerization interface [polypeptide binding]; other site 713604007118 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 713604007119 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 713604007120 tetrameric interface [polypeptide binding]; other site 713604007121 NAD binding site [chemical binding]; other site 713604007122 catalytic residues [active] 713604007123 substrate binding site [chemical binding]; other site 713604007124 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 713604007125 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604007126 PYR/PP interface [polypeptide binding]; other site 713604007127 dimer interface [polypeptide binding]; other site 713604007128 TPP binding site [chemical binding]; other site 713604007129 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604007130 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 713604007131 TPP-binding site [chemical binding]; other site 713604007132 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 713604007133 agmatinase; Region: agmatinase; TIGR01230 713604007134 oligomer interface [polypeptide binding]; other site 713604007135 putative active site [active] 713604007136 Mn binding site [ion binding]; other site 713604007137 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 713604007138 Na binding site [ion binding]; other site 713604007139 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 713604007140 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604007141 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604007142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604007143 active site 713604007144 phosphorylation site [posttranslational modification] 713604007145 intermolecular recognition site; other site 713604007146 dimerization interface [polypeptide binding]; other site 713604007147 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604007148 DNA binding site [nucleotide binding] 713604007149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604007150 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604007151 dimerization interface [polypeptide binding]; other site 713604007152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604007153 dimer interface [polypeptide binding]; other site 713604007154 phosphorylation site [posttranslational modification] 713604007155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604007156 ATP binding site [chemical binding]; other site 713604007157 Mg2+ binding site [ion binding]; other site 713604007158 G-X-G motif; other site 713604007159 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604007160 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604007161 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 713604007162 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 713604007163 active site 713604007164 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604007165 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 713604007166 substrate binding site [chemical binding]; other site 713604007167 oxyanion hole (OAH) forming residues; other site 713604007168 trimer interface [polypeptide binding]; other site 713604007169 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604007170 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604007171 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604007172 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 713604007173 dimer interface [polypeptide binding]; other site 713604007174 active site 713604007175 allophanate hydrolase; Provisional; Region: PRK08186 713604007176 Amidase; Region: Amidase; cl11426 713604007177 urea carboxylase; Region: urea_carbox; TIGR02712 713604007178 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604007179 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604007180 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 713604007181 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 713604007182 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 713604007183 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604007184 carboxyltransferase (CT) interaction site; other site 713604007185 biotinylation site [posttranslational modification]; other site 713604007186 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604007187 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 713604007188 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 713604007189 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 713604007190 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 713604007191 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 713604007192 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 713604007193 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 713604007194 catalytic site [active] 713604007195 putative active site [active] 713604007196 putative substrate binding site [chemical binding]; other site 713604007197 Helicase and RNase D C-terminal; Region: HRDC; smart00341 713604007198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604007199 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604007200 active site 713604007201 phosphorylation site [posttranslational modification] 713604007202 intermolecular recognition site; other site 713604007203 dimerization interface [polypeptide binding]; other site 713604007204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604007205 DNA binding residues [nucleotide binding] 713604007206 dimerization interface [polypeptide binding]; other site 713604007207 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 713604007208 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 713604007209 substrate binding site [chemical binding]; other site 713604007210 active site 713604007211 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 713604007212 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604007213 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 713604007214 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604007215 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604007216 hypothetical protein; Provisional; Region: PRK05409 713604007217 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604007218 TIGR04222 domain; Region: near_uncomplex 713604007219 TIGR04222 domain; Region: near_uncomplex 713604007220 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 713604007221 SelR domain; Region: SelR; pfam01641 713604007222 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604007223 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604007224 active site 713604007225 ATP binding site [chemical binding]; other site 713604007226 substrate binding site [chemical binding]; other site 713604007227 activation loop (A-loop); other site 713604007228 Uncharacterized conserved protein [Function unknown]; Region: COG0398 713604007229 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 713604007230 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 713604007231 nucleotide binding site [chemical binding]; other site 713604007232 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 713604007233 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604007234 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 713604007235 RNA binding site [nucleotide binding]; other site 713604007236 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604007237 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604007238 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 713604007239 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 713604007240 Glutamate binding site [chemical binding]; other site 713604007241 NAD binding site [chemical binding]; other site 713604007242 catalytic residues [active] 713604007243 potential frameshift: common BLAST hit: gi|300784568|ref|YP_003764859.1| proline dehydrogenase 713604007244 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 713604007245 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 713604007246 catalytic residues [active] 713604007247 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 713604007248 YCII-related domain; Region: YCII; cl00999 713604007249 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 713604007250 putative dimer interface [polypeptide binding]; other site 713604007251 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604007252 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604007253 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604007254 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604007255 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604007256 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604007257 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 713604007258 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 713604007259 active site 713604007260 DNA binding site [nucleotide binding] 713604007261 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 713604007262 DNA binding site [nucleotide binding] 713604007263 Asp23 family; Region: Asp23; cl00574 713604007264 Asp23 family; Region: Asp23; pfam03780 713604007265 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 713604007266 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604007267 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604007268 DNA binding residues [nucleotide binding] 713604007269 hypothetical protein; Provisional; Region: PRK14059 713604007270 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 713604007271 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 713604007272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604007273 Walker A motif; other site 713604007274 ATP binding site [chemical binding]; other site 713604007275 Walker B motif; other site 713604007276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604007277 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 713604007278 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 713604007279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 713604007280 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 713604007281 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604007282 inhibitor-cofactor binding pocket; inhibition site 713604007283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604007284 catalytic residue [active] 713604007285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604007286 dimerization interface [polypeptide binding]; other site 713604007287 putative DNA binding site [nucleotide binding]; other site 713604007288 putative Zn2+ binding site [ion binding]; other site 713604007289 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 713604007290 putative hydrophobic ligand binding site [chemical binding]; other site 713604007291 CLM binding site; other site 713604007292 L1 loop; other site 713604007293 DNA binding site [nucleotide binding] 713604007294 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 713604007295 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 713604007296 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604007297 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 713604007298 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604007299 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 713604007300 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 713604007301 CrcB-like protein; Region: CRCB; pfam02537 713604007302 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 713604007303 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604007304 catalytic residue [active] 713604007305 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 713604007306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604007307 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 713604007308 IucA / IucC family; Region: IucA_IucC; pfam04183 713604007309 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 713604007310 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 713604007311 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604007312 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604007313 FAD binding domain; Region: FAD_binding_4; pfam01565 713604007314 Berberine and berberine like; Region: BBE; pfam08031 713604007315 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 713604007316 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 713604007317 AAA ATPase domain; Region: AAA_16; pfam13191 713604007318 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 713604007319 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604007320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604007321 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604007322 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 713604007323 protein-splicing catalytic site; other site 713604007324 thioester formation/cholesterol transfer; other site 713604007325 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 713604007326 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 713604007327 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604007328 FeS/SAM binding site; other site 713604007329 alkylmercury lyase; Provisional; Region: PRK13239 713604007330 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 713604007331 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 713604007332 dimer interface [polypeptide binding]; other site 713604007333 anticodon binding site; other site 713604007334 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 713604007335 homodimer interface [polypeptide binding]; other site 713604007336 motif 1; other site 713604007337 active site 713604007338 motif 2; other site 713604007339 GAD domain; Region: GAD; pfam02938 713604007340 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604007341 active site 713604007342 motif 3; other site 713604007343 Domain of unknown function (DUF389); Region: DUF389; cl00781 713604007344 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 713604007345 active site 713604007346 catalytic triad [active] 713604007347 oxyanion hole [active] 713604007348 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604007349 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 713604007350 active site 713604007351 metal binding site [ion binding]; metal-binding site 713604007352 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604007353 Cytochrome P450; Region: p450; cl12078 713604007354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007356 recombination factor protein RarA; Reviewed; Region: PRK13342 713604007357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604007358 Walker A motif; other site 713604007359 ATP binding site [chemical binding]; other site 713604007360 Walker B motif; other site 713604007361 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 713604007362 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604007363 active site 713604007364 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 713604007365 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 713604007366 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 713604007367 motif 1; other site 713604007368 active site 713604007369 motif 2; other site 713604007370 motif 3; other site 713604007371 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 713604007372 DHHA1 domain; Region: DHHA1; pfam02272 713604007373 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 713604007374 YceG-like family; Region: YceG; pfam02618 713604007375 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 713604007376 dimerization interface [polypeptide binding]; other site 713604007377 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 713604007378 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 713604007379 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 713604007380 shikimate binding site; other site 713604007381 NAD(P) binding site [chemical binding]; other site 713604007382 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 713604007383 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604007384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604007385 S-adenosylmethionine binding site [chemical binding]; other site 713604007386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007388 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604007389 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 713604007390 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 713604007391 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604007392 dimerization interface [polypeptide binding]; other site 713604007393 NAD binding site [chemical binding]; other site 713604007394 ligand binding site [chemical binding]; other site 713604007395 catalytic site [active] 713604007396 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604007397 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604007398 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 713604007399 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 713604007400 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 713604007401 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604007402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604007403 DNA-binding site [nucleotide binding]; DNA binding site 713604007404 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 713604007405 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 713604007406 active site turn [active] 713604007407 phosphorylation site [posttranslational modification] 713604007408 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 713604007409 HPr interaction site; other site 713604007410 glycerol kinase (GK) interaction site [polypeptide binding]; other site 713604007411 active site 713604007412 phosphorylation site [posttranslational modification] 713604007413 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604007414 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 713604007415 iron-sulfur cluster [ion binding]; other site 713604007416 [2Fe-2S] cluster binding site [ion binding]; other site 713604007417 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 713604007418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604007419 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604007420 DNA binding residues [nucleotide binding] 713604007421 Putative zinc-finger; Region: zf-HC2; pfam13490 713604007422 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 713604007423 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 713604007424 Tetramer interface [polypeptide binding]; other site 713604007425 active site 713604007426 FMN-binding site [chemical binding]; other site 713604007427 shikimate kinase; Reviewed; Region: aroK; PRK00131 713604007428 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 713604007429 ADP binding site [chemical binding]; other site 713604007430 magnesium binding site [ion binding]; other site 713604007431 putative shikimate binding site; other site 713604007432 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 713604007433 active site 713604007434 dimer interface [polypeptide binding]; other site 713604007435 metal binding site [ion binding]; metal-binding site 713604007436 Dehydroquinase class II; Region: DHquinase_II; pfam01220 713604007437 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 713604007438 trimer interface [polypeptide binding]; other site 713604007439 active site 713604007440 dimer interface [polypeptide binding]; other site 713604007441 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604007442 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604007443 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 713604007444 putative dimer interface [polypeptide binding]; other site 713604007445 ligand binding site [chemical binding]; other site 713604007446 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 713604007447 active site 713604007448 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 713604007449 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 713604007450 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 713604007451 active site 713604007452 elongation factor P; Validated; Region: PRK00529 713604007453 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 713604007454 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 713604007455 RNA binding site [nucleotide binding]; other site 713604007456 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 713604007457 RNA binding site [nucleotide binding]; other site 713604007458 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 713604007459 putative RNA binding site [nucleotide binding]; other site 713604007460 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604007461 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604007462 active site 713604007463 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604007464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604007465 non-specific DNA binding site [nucleotide binding]; other site 713604007466 salt bridge; other site 713604007467 sequence-specific DNA binding site [nucleotide binding]; other site 713604007468 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 713604007469 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 713604007470 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 713604007471 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 713604007472 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 713604007473 dihydroorotase; Validated; Region: pyrC; PRK09357 713604007474 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604007475 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 713604007476 active site 713604007477 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 713604007478 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 713604007479 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 713604007480 catalytic site [active] 713604007481 subunit interface [polypeptide binding]; other site 713604007482 Predicted ATPase [General function prediction only]; Region: COG4637 713604007483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604007484 Walker A/P-loop; other site 713604007485 ATP binding site [chemical binding]; other site 713604007486 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 713604007487 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 713604007488 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604007489 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 713604007490 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 713604007491 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604007492 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604007493 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 713604007494 IMP binding site; other site 713604007495 dimer interface [polypeptide binding]; other site 713604007496 interdomain contacts; other site 713604007497 partial ornithine binding site; other site 713604007498 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 713604007499 active site 713604007500 dimer interface [polypeptide binding]; other site 713604007501 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 713604007502 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 713604007503 catalytic site [active] 713604007504 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 713604007505 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 713604007506 Flavoprotein; Region: Flavoprotein; pfam02441 713604007507 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 713604007508 S-adenosylmethionine synthetase; Validated; Region: PRK05250 713604007509 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 713604007510 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 713604007511 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 713604007512 primosome assembly protein PriA; Provisional; Region: PRK14873 713604007513 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 713604007514 CotH protein; Region: CotH; pfam08757 713604007515 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 713604007516 putative substrate binding pocket [chemical binding]; other site 713604007517 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 713604007518 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 713604007519 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 713604007520 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 713604007521 putative active site [active] 713604007522 substrate binding site [chemical binding]; other site 713604007523 putative cosubstrate binding site; other site 713604007524 catalytic site [active] 713604007525 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 713604007526 substrate binding site [chemical binding]; other site 713604007527 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 713604007528 putative RNA binding site [nucleotide binding]; other site 713604007529 16S rRNA methyltransferase B; Provisional; Region: PRK14902 713604007530 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 713604007531 Flavoprotein; Region: Flavoprotein; cl08021 713604007532 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604007533 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604007534 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 713604007535 dimer interface [polypeptide binding]; other site 713604007536 Alkaline phosphatase homologues; Region: alkPPc; smart00098 713604007537 active site 713604007538 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604007539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604007540 active site 713604007541 phosphorylation site [posttranslational modification] 713604007542 intermolecular recognition site; other site 713604007543 dimerization interface [polypeptide binding]; other site 713604007544 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604007545 DNA binding residues [nucleotide binding] 713604007546 dimerization interface [polypeptide binding]; other site 713604007547 Histidine kinase; Region: HisKA_3; pfam07730 713604007548 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604007549 ATP binding site [chemical binding]; other site 713604007550 Mg2+ binding site [ion binding]; other site 713604007551 G-X-G motif; other site 713604007552 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 713604007553 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 713604007554 substrate binding site [chemical binding]; other site 713604007555 hexamer interface [polypeptide binding]; other site 713604007556 metal binding site [ion binding]; metal-binding site 713604007557 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 713604007558 Lumazine binding domain; Region: Lum_binding; pfam00677 713604007559 Lumazine binding domain; Region: Lum_binding; pfam00677 713604007560 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 713604007561 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 713604007562 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 713604007563 dimerization interface [polypeptide binding]; other site 713604007564 active site 713604007565 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 713604007566 homopentamer interface [polypeptide binding]; other site 713604007567 active site 713604007568 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 713604007569 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 713604007570 putative catalytic site [active] 713604007571 putative phosphate binding site [ion binding]; other site 713604007572 active site 713604007573 metal binding site A [ion binding]; metal-binding site 713604007574 DNA binding site [nucleotide binding] 713604007575 putative AP binding site [nucleotide binding]; other site 713604007576 putative metal binding site B [ion binding]; other site 713604007577 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604007578 cleavage site 713604007579 active site 713604007580 substrate binding sites [chemical binding]; other site 713604007581 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 713604007582 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 713604007583 active site 713604007584 GIY-YIG motif/motif A; other site 713604007585 catalytic site [active] 713604007586 putative DNA binding site [nucleotide binding]; other site 713604007587 metal binding site [ion binding]; metal-binding site 713604007588 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 713604007589 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 713604007590 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 713604007591 dimer interface [polypeptide binding]; other site 713604007592 phosphate binding site [ion binding]; other site 713604007593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 713604007594 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 713604007595 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 713604007596 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 713604007597 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 713604007598 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 713604007599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007601 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 713604007602 Ca binding site [ion binding]; other site 713604007603 Ca binding site (active) [ion binding]; other site 713604007604 ligand binding site [chemical binding]; other site 713604007605 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604007606 Interdomain contacts; other site 713604007607 Cytokine receptor motif; other site 713604007608 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604007609 Interdomain contacts; other site 713604007610 Cytokine receptor motif; other site 713604007611 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604007612 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604007613 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 713604007614 substrate binding site [chemical binding]; other site 713604007615 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 713604007616 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 713604007617 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604007618 MAEBL; Provisional; Region: PTZ00121 713604007619 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 713604007620 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604007621 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604007622 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604007623 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604007624 dimerization interface [polypeptide binding]; other site 713604007625 putative DNA binding site [nucleotide binding]; other site 713604007626 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604007627 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604007628 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 713604007629 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 713604007630 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 713604007631 Phosphoglycerate kinase; Region: PGK; pfam00162 713604007632 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 713604007633 substrate binding site [chemical binding]; other site 713604007634 hinge regions; other site 713604007635 ADP binding site [chemical binding]; other site 713604007636 catalytic site [active] 713604007637 triosephosphate isomerase; Provisional; Region: PRK14567 713604007638 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 713604007639 substrate binding site [chemical binding]; other site 713604007640 dimer interface [polypeptide binding]; other site 713604007641 catalytic triad [active] 713604007642 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 713604007643 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604007644 Histidine kinase; Region: HisKA_3; pfam07730 713604007645 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604007646 ATP binding site [chemical binding]; other site 713604007647 Mg2+ binding site [ion binding]; other site 713604007648 G-X-G motif; other site 713604007649 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 713604007650 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 713604007651 putative active site [active] 713604007652 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 713604007653 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 713604007654 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 713604007655 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 713604007656 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 713604007657 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 713604007658 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 713604007659 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 713604007660 putative active site [active] 713604007661 transaldolase; Provisional; Region: PRK03903 713604007662 catalytic residue [active] 713604007663 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 713604007664 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 713604007665 TPP-binding site [chemical binding]; other site 713604007666 dimer interface [polypeptide binding]; other site 713604007667 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 713604007668 PYR/PP interface [polypeptide binding]; other site 713604007669 dimer interface [polypeptide binding]; other site 713604007670 TPP binding site [chemical binding]; other site 713604007671 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604007672 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 713604007673 UbiA prenyltransferase family; Region: UbiA; pfam01040 713604007674 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 713604007675 Part of AAA domain; Region: AAA_19; pfam13245 713604007676 Family description; Region: UvrD_C_2; pfam13538 713604007677 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 713604007678 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 713604007679 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 713604007680 NADP binding site [chemical binding]; other site 713604007681 dimer interface [polypeptide binding]; other site 713604007682 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 713604007683 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604007684 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604007685 Di-iron ligands [ion binding]; other site 713604007686 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 713604007687 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 713604007688 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604007689 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604007690 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604007691 Walker A/P-loop; other site 713604007692 ATP binding site [chemical binding]; other site 713604007693 Q-loop/lid; other site 713604007694 ABC transporter signature motif; other site 713604007695 Walker B; other site 713604007696 D-loop; other site 713604007697 H-loop/switch region; other site 713604007698 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 713604007699 Predicted transcriptional regulator [Transcription]; Region: COG2345 713604007700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604007701 putative DNA binding site [nucleotide binding]; other site 713604007702 putative Zn2+ binding site [ion binding]; other site 713604007703 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 713604007704 FeS assembly protein SufB; Region: sufB; TIGR01980 713604007705 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 713604007706 FeS assembly protein SufD; Region: sufD; TIGR01981 713604007707 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 713604007708 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 713604007709 Walker A/P-loop; other site 713604007710 ATP binding site [chemical binding]; other site 713604007711 Q-loop/lid; other site 713604007712 ABC transporter signature motif; other site 713604007713 Walker B; other site 713604007714 D-loop; other site 713604007715 H-loop/switch region; other site 713604007716 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604007717 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 713604007718 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604007719 catalytic residue [active] 713604007720 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 713604007721 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 713604007722 trimerization site [polypeptide binding]; other site 713604007723 active site 713604007724 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 713604007725 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 713604007726 hypothetical protein; Provisional; Region: PRK02237 713604007727 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 713604007728 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 713604007729 Catalytic site [active] 713604007730 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 713604007731 ABC1 family; Region: ABC1; cl17513 713604007732 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 713604007733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604007734 Histidine kinase; Region: HisKA_3; pfam07730 713604007735 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604007736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604007737 active site 713604007738 phosphorylation site [posttranslational modification] 713604007739 intermolecular recognition site; other site 713604007740 dimerization interface [polypeptide binding]; other site 713604007741 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604007742 DNA binding residues [nucleotide binding] 713604007743 dimerization interface [polypeptide binding]; other site 713604007744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604007745 S-adenosylmethionine binding site [chemical binding]; other site 713604007746 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 713604007747 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 713604007748 CysD dimerization site [polypeptide binding]; other site 713604007749 G1 box; other site 713604007750 putative GEF interaction site [polypeptide binding]; other site 713604007751 GTP/Mg2+ binding site [chemical binding]; other site 713604007752 Switch I region; other site 713604007753 G2 box; other site 713604007754 G3 box; other site 713604007755 Switch II region; other site 713604007756 G4 box; other site 713604007757 G5 box; other site 713604007758 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 713604007759 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 713604007760 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 713604007761 ligand-binding site [chemical binding]; other site 713604007762 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 713604007763 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 713604007764 Active Sites [active] 713604007765 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604007766 short chain dehydrogenase; Provisional; Region: PRK07890 713604007767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604007768 NAD(P) binding site [chemical binding]; other site 713604007769 active site 713604007770 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 713604007771 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604007772 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604007773 active site 713604007774 TDP-binding site; other site 713604007775 acceptor substrate-binding pocket; other site 713604007776 homodimer interface [polypeptide binding]; other site 713604007777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007778 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604007779 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604007780 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604007781 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604007782 metal binding site [ion binding]; metal-binding site 713604007783 active site 713604007784 I-site; other site 713604007785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604007786 dimerization interface [polypeptide binding]; other site 713604007787 putative DNA binding site [nucleotide binding]; other site 713604007788 putative Zn2+ binding site [ion binding]; other site 713604007789 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 713604007790 putative hydrophobic ligand binding site [chemical binding]; other site 713604007791 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604007792 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 713604007793 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604007794 Zn2+ binding site [ion binding]; other site 713604007795 Mg2+ binding site [ion binding]; other site 713604007796 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 713604007797 putative active site [active] 713604007798 putative catalytic triad [active] 713604007799 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 713604007800 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 713604007801 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 713604007802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604007803 Walker A/P-loop; other site 713604007804 ATP binding site [chemical binding]; other site 713604007805 Q-loop/lid; other site 713604007806 ABC transporter signature motif; other site 713604007807 Walker B; other site 713604007808 D-loop; other site 713604007809 H-loop/switch region; other site 713604007810 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604007811 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604007812 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604007813 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604007814 MarR family; Region: MarR_2; pfam12802 713604007815 MarR family; Region: MarR_2; cl17246 713604007816 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604007817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604007818 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604007819 Walker A/P-loop; other site 713604007820 ATP binding site [chemical binding]; other site 713604007821 Q-loop/lid; other site 713604007822 ABC transporter signature motif; other site 713604007823 Walker B; other site 713604007824 D-loop; other site 713604007825 H-loop/switch region; other site 713604007826 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604007827 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604007828 hypothetical protein; Provisional; Region: PRK02947 713604007829 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 713604007830 putative active site [active] 713604007831 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604007832 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 713604007833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604007834 S-adenosylmethionine binding site [chemical binding]; other site 713604007835 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604007836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604007837 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604007838 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 713604007839 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 713604007840 catalytic triad [active] 713604007841 PAS fold; Region: PAS_4; pfam08448 713604007842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604007843 putative active site [active] 713604007844 heme pocket [chemical binding]; other site 713604007845 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604007846 metal binding site [ion binding]; metal-binding site 713604007847 active site 713604007848 I-site; other site 713604007849 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604007850 Cytochrome P450; Region: p450; cl12078 713604007851 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604007852 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604007853 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604007854 nudix motif; other site 713604007855 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 713604007856 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 713604007857 dimer interface [polypeptide binding]; other site 713604007858 putative radical transfer pathway; other site 713604007859 diiron center [ion binding]; other site 713604007860 tyrosyl radical; other site 713604007861 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 713604007862 ATP cone domain; Region: ATP-cone; pfam03477 713604007863 Class I ribonucleotide reductase; Region: RNR_I; cd01679 713604007864 active site 713604007865 dimer interface [polypeptide binding]; other site 713604007866 catalytic residues [active] 713604007867 effector binding site; other site 713604007868 R2 peptide binding site; other site 713604007869 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 713604007870 enoyl-CoA hydratase; Provisional; Region: PRK08260 713604007871 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604007872 substrate binding site [chemical binding]; other site 713604007873 oxyanion hole (OAH) forming residues; other site 713604007874 trimer interface [polypeptide binding]; other site 713604007875 HEAT repeats; Region: HEAT_2; pfam13646 713604007876 TIGR03084 family protein; Region: TIGR03084 713604007877 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604007878 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 713604007879 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604007880 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604007881 active site 713604007882 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 713604007883 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 713604007884 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 713604007885 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604007886 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604007887 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 713604007888 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604007889 carboxyltransferase (CT) interaction site; other site 713604007890 biotinylation site [posttranslational modification]; other site 713604007891 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604007892 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604007893 active site 713604007894 short chain dehydrogenase; Provisional; Region: PRK08278 713604007895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604007896 NAD(P) binding site [chemical binding]; other site 713604007897 active site 713604007898 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007900 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 713604007901 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 713604007902 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 713604007903 active site 713604007904 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604007905 metal binding site [ion binding]; metal-binding site 713604007906 active site 713604007907 I-site; other site 713604007908 oxidase reductase; Provisional; Region: PTZ00273 713604007909 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 713604007910 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 713604007911 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 713604007912 nucleoside/Zn binding site; other site 713604007913 dimer interface [polypeptide binding]; other site 713604007914 catalytic motif [active] 713604007915 HTH domain; Region: HTH_11; pfam08279 713604007916 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604007917 WYL domain; Region: WYL; pfam13280 713604007918 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604007919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007921 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 713604007922 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 713604007923 dimer interface [polypeptide binding]; other site 713604007924 active site 713604007925 CoA binding pocket [chemical binding]; other site 713604007926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007928 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604007929 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604007930 putative sugar binding sites [chemical binding]; other site 713604007931 Q-X-W motif; other site 713604007932 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 713604007933 active site 713604007934 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604007935 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604007936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007937 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604007938 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604007939 DNA binding residues [nucleotide binding] 713604007940 dimer interface [polypeptide binding]; other site 713604007941 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604007942 Helix-turn-helix domain; Region: HTH_31; pfam13560 713604007943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604007944 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604007945 Walker A/P-loop; other site 713604007946 ATP binding site [chemical binding]; other site 713604007947 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 713604007948 structural tetrad; other site 713604007949 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604007950 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 713604007951 structural tetrad; other site 713604007952 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 713604007953 hypothetical protein; Provisional; Region: PRK07236 713604007954 hypothetical protein; Provisional; Region: PRK06834 713604007955 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604007956 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604007957 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604007958 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604007959 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604007960 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604007961 AsnC family; Region: AsnC_trans_reg; pfam01037 713604007962 CHAT domain; Region: CHAT; pfam12770 713604007963 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604007964 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604007965 MarR family; Region: MarR_2; pfam12802 713604007966 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604007967 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604007968 RDD family; Region: RDD; pfam06271 713604007969 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604007970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604007971 active site 713604007972 phosphorylation site [posttranslational modification] 713604007973 intermolecular recognition site; other site 713604007974 dimerization interface [polypeptide binding]; other site 713604007975 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604007976 DNA binding residues [nucleotide binding] 713604007977 dimerization interface [polypeptide binding]; other site 713604007978 Histidine kinase; Region: HisKA_3; pfam07730 713604007979 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604007980 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 713604007981 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604007982 active site 713604007983 catalytic residues [active] 713604007984 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604007985 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604007986 dimerization interface [polypeptide binding]; other site 713604007987 ligand binding site [chemical binding]; other site 713604007988 4Fe-4S binding domain; Region: Fer4; pfam00037 713604007989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007992 short chain dehydrogenase; Provisional; Region: PRK08263 713604007993 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604007994 NADP binding site [chemical binding]; other site 713604007995 active site 713604007996 steroid binding site; other site 713604007997 OsmC-like protein; Region: OsmC; cl00767 713604007998 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604007999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604008000 putative Zn2+ binding site [ion binding]; other site 713604008001 putative DNA binding site [nucleotide binding]; other site 713604008002 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604008003 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 713604008004 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 713604008005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604008006 S-adenosylmethionine binding site [chemical binding]; other site 713604008007 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 713604008008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604008009 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 713604008010 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 713604008011 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604008012 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604008013 DNA binding residues [nucleotide binding] 713604008014 cell division protein FtsZ; Validated; Region: PRK09330 713604008015 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 713604008016 nucleotide binding site [chemical binding]; other site 713604008017 SulA interaction site; other site 713604008018 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 713604008019 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 713604008020 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 713604008021 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604008022 catalytic residue [active] 713604008023 Protein of unknown function (DUF552); Region: DUF552; pfam04472 713604008024 Predicted integral membrane protein [Function unknown]; Region: COG0762 713604008025 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604008026 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 713604008027 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 713604008028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604008029 putative DNA binding site [nucleotide binding]; other site 713604008030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008031 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604008032 putative substrate translocation pore; other site 713604008033 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 713604008034 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 713604008035 HIGH motif; other site 713604008036 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 713604008037 active site 713604008038 KMSKS motif; other site 713604008039 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 713604008040 tRNA binding surface [nucleotide binding]; other site 713604008041 anticodon binding site; other site 713604008042 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 713604008043 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604008044 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604008045 dimerization interface [polypeptide binding]; other site 713604008046 putative DNA binding site [nucleotide binding]; other site 713604008047 putative Zn2+ binding site [ion binding]; other site 713604008048 potassium/proton antiporter; Reviewed; Region: PRK05326 713604008049 TrkA-C domain; Region: TrkA_C; pfam02080 713604008050 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604008051 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604008052 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604008053 catalytic residue [active] 713604008054 lipoprotein signal peptidase; Provisional; Region: PRK14764 713604008055 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 713604008056 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 713604008057 RNA binding surface [nucleotide binding]; other site 713604008058 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 713604008059 active site 713604008060 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 713604008061 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 713604008062 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 713604008063 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 713604008064 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 713604008065 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 713604008066 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604008067 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 713604008068 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604008069 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 713604008070 active site 713604008071 catalytic site [active] 713604008072 exopolyphosphatase; Region: exo_poly_only; TIGR03706 713604008073 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 713604008074 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 713604008075 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 713604008076 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 713604008077 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 713604008078 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 713604008079 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604008080 motif II; other site 713604008081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604008082 dimerization interface [polypeptide binding]; other site 713604008083 putative DNA binding site [nucleotide binding]; other site 713604008084 putative Zn2+ binding site [ion binding]; other site 713604008085 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604008086 CoenzymeA binding site [chemical binding]; other site 713604008087 subunit interaction site [polypeptide binding]; other site 713604008088 PHB binding site; other site 713604008089 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604008090 MarR family; Region: MarR_2; pfam12802 713604008091 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604008092 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604008093 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604008094 nucleotide binding site [chemical binding]; other site 713604008095 Butyrate kinase [Energy production and conversion]; Region: COG3426 713604008096 Domain of unknown function (DUF427); Region: DUF427; pfam04248 713604008097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 713604008098 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 713604008099 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 713604008100 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604008101 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604008102 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 713604008103 Predicted integral membrane protein [Function unknown]; Region: COG5660 713604008104 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 713604008105 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604008106 DNA binding residues [nucleotide binding] 713604008107 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604008108 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604008109 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604008110 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604008111 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604008112 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 713604008113 catalytic loop [active] 713604008114 iron binding site [ion binding]; other site 713604008115 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604008116 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604008117 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 713604008118 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604008119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008121 short chain dehydrogenase; Provisional; Region: PRK08263 713604008122 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604008123 NADP binding site [chemical binding]; other site 713604008124 active site 713604008125 steroid binding site; other site 713604008126 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604008127 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604008128 active site 713604008129 catalytic tetrad [active] 713604008130 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604008131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604008132 Walker A motif; other site 713604008133 ATP binding site [chemical binding]; other site 713604008134 Walker B motif; other site 713604008135 arginine finger; other site 713604008136 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604008137 metal ion-dependent adhesion site (MIDAS); other site 713604008138 adenosine deaminase; Provisional; Region: PRK09358 713604008139 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 713604008140 active site 713604008141 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 713604008142 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 713604008143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604008144 ATP binding site [chemical binding]; other site 713604008145 putative Mg++ binding site [ion binding]; other site 713604008146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604008147 nucleotide binding region [chemical binding]; other site 713604008148 ATP-binding site [chemical binding]; other site 713604008149 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 713604008150 HRDC domain; Region: HRDC; pfam00570 713604008151 short chain dehydrogenase; Provisional; Region: PRK12937 713604008152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604008153 NAD(P) binding site [chemical binding]; other site 713604008154 active site 713604008155 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604008156 DinB superfamily; Region: DinB_2; pfam12867 713604008157 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 713604008158 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 713604008159 DNA binding residues [nucleotide binding] 713604008160 dimer interface [polypeptide binding]; other site 713604008161 [2Fe-2S] cluster binding site [ion binding]; other site 713604008162 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604008163 Predicted flavoprotein [General function prediction only]; Region: COG0431 713604008164 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604008165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604008166 dimerization interface [polypeptide binding]; other site 713604008167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604008168 dimer interface [polypeptide binding]; other site 713604008169 phosphorylation site [posttranslational modification] 713604008170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604008171 ATP binding site [chemical binding]; other site 713604008172 Mg2+ binding site [ion binding]; other site 713604008173 G-X-G motif; other site 713604008174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604008175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604008176 active site 713604008177 phosphorylation site [posttranslational modification] 713604008178 intermolecular recognition site; other site 713604008179 dimerization interface [polypeptide binding]; other site 713604008180 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604008181 DNA binding site [nucleotide binding] 713604008182 PAP2 superfamily; Region: PAP2; pfam01569 713604008183 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 713604008184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604008185 catalytic residue [active] 713604008186 hypothetical protein; Provisional; Region: PRK08266 713604008187 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604008188 PYR/PP interface [polypeptide binding]; other site 713604008189 dimer interface [polypeptide binding]; other site 713604008190 TPP binding site [chemical binding]; other site 713604008191 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604008192 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 713604008193 TPP-binding site [chemical binding]; other site 713604008194 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604008195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 713604008196 DNA-binding site [nucleotide binding]; DNA binding site 713604008197 FCD domain; Region: FCD; pfam07729 713604008198 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604008199 Pirin-related protein [General function prediction only]; Region: COG1741 713604008200 Pirin; Region: Pirin; pfam02678 713604008201 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 713604008202 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 713604008203 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 713604008204 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 713604008205 dimer interface [polypeptide binding]; other site 713604008206 ssDNA binding site [nucleotide binding]; other site 713604008207 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604008208 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604008209 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 713604008210 Transglycosylase; Region: Transgly; pfam00912 713604008211 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604008212 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604008213 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604008214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604008215 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604008216 Q-loop/lid; other site 713604008217 ABC transporter signature motif; other site 713604008218 Walker B; other site 713604008219 D-loop; other site 713604008220 H-loop/switch region; other site 713604008221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604008222 Walker A/P-loop; other site 713604008223 ATP binding site [chemical binding]; other site 713604008224 MarR family; Region: MarR_2; cl17246 713604008225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604008226 dimerization interface [polypeptide binding]; other site 713604008227 putative DNA binding site [nucleotide binding]; other site 713604008228 putative Zn2+ binding site [ion binding]; other site 713604008229 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 713604008230 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 713604008231 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 713604008232 putative NAD(P) binding site [chemical binding]; other site 713604008233 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604008234 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 713604008235 dimer interface [polypeptide binding]; other site 713604008236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604008237 Coenzyme A binding pocket [chemical binding]; other site 713604008238 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604008239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604008240 ATP binding site [chemical binding]; other site 713604008241 Mg2+ binding site [ion binding]; other site 713604008242 G-X-G motif; other site 713604008243 Carboxylesterase family; Region: COesterase; pfam00135 713604008244 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604008245 substrate binding pocket [chemical binding]; other site 713604008246 catalytic triad [active] 713604008247 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604008248 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604008249 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604008250 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604008251 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 713604008252 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604008253 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604008254 catalytic loop [active] 713604008255 iron binding site [ion binding]; other site 713604008256 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604008257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008259 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 713604008260 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 713604008261 tetrameric interface [polypeptide binding]; other site 713604008262 NAD binding site [chemical binding]; other site 713604008263 catalytic residues [active] 713604008264 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604008265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604008266 DNA-binding site [nucleotide binding]; DNA binding site 713604008267 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 713604008268 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 713604008269 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604008270 NAD binding site [chemical binding]; other site 713604008271 catalytic Zn binding site [ion binding]; other site 713604008272 structural Zn binding site [ion binding]; other site 713604008273 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604008274 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 713604008275 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 713604008276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604008277 ATP binding site [chemical binding]; other site 713604008278 Mg2+ binding site [ion binding]; other site 713604008279 G-X-G motif; other site 713604008280 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 713604008281 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 713604008282 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 713604008283 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604008284 MarR family; Region: MarR; pfam01047 713604008285 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604008286 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 713604008287 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 713604008288 putative dimer interface [polypeptide binding]; other site 713604008289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604008290 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604008291 NAD(P) binding site [chemical binding]; other site 713604008292 active site 713604008293 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 713604008294 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 713604008295 D-pathway; other site 713604008296 Putative ubiquinol binding site [chemical binding]; other site 713604008297 Low-spin heme (heme b) binding site [chemical binding]; other site 713604008298 Putative water exit pathway; other site 713604008299 Binuclear center (heme o3/CuB) [ion binding]; other site 713604008300 K-pathway; other site 713604008301 Putative proton exit pathway; other site 713604008302 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 713604008303 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 713604008304 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 713604008305 active site 713604008306 catalytic site [active] 713604008307 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 713604008308 dimanganese center [ion binding]; other site 713604008309 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604008310 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 713604008311 NADP binding site [chemical binding]; other site 713604008312 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604008313 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604008314 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604008315 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 713604008316 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 713604008317 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604008318 active site 713604008319 catalytic triad [active] 713604008320 oxyanion hole [active] 713604008321 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604008322 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604008323 DNA binding site [nucleotide binding] 713604008324 domain linker motif; other site 713604008325 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604008326 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604008327 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604008328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008329 dimer interface [polypeptide binding]; other site 713604008330 conserved gate region; other site 713604008331 putative PBP binding loops; other site 713604008332 ABC-ATPase subunit interface; other site 713604008333 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604008334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008335 dimer interface [polypeptide binding]; other site 713604008336 conserved gate region; other site 713604008337 putative PBP binding loops; other site 713604008338 ABC-ATPase subunit interface; other site 713604008339 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 713604008340 legume lectins; Region: lectin_L-type; cl14058 713604008341 homotetramer interaction site [polypeptide binding]; other site 713604008342 hypothetical protein; Provisional; Region: PRK06215 713604008343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008344 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604008345 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604008346 active site 713604008347 catalytic tetrad [active] 713604008348 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604008349 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604008350 conserved cys residue [active] 713604008351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604008352 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604008353 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604008354 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604008355 active site 713604008356 catalytic tetrad [active] 713604008357 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 713604008358 dimer interface [polypeptide binding]; other site 713604008359 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604008360 HTH domain; Region: HTH_11; pfam08279 713604008361 WYL domain; Region: WYL; pfam13280 713604008362 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 713604008363 Ligand Binding Site [chemical binding]; other site 713604008364 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 713604008365 AIR carboxylase; Region: AIRC; smart01001 713604008366 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 713604008367 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 713604008368 Amidohydrolase; Region: Amidohydro_2; pfam04909 713604008369 active site 713604008370 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604008371 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604008372 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 713604008373 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604008374 metal binding site [ion binding]; metal-binding site 713604008375 substrate binding pocket [chemical binding]; other site 713604008376 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604008377 classical (c) SDRs; Region: SDR_c; cd05233 713604008378 NAD(P) binding site [chemical binding]; other site 713604008379 active site 713604008380 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 713604008381 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604008382 ligand binding site [chemical binding]; other site 713604008383 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 713604008384 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604008385 Walker A/P-loop; other site 713604008386 ATP binding site [chemical binding]; other site 713604008387 Q-loop/lid; other site 713604008388 ABC transporter signature motif; other site 713604008389 Walker B; other site 713604008390 D-loop; other site 713604008391 H-loop/switch region; other site 713604008392 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604008393 ABC transporter; Region: ABC_tran; pfam00005 713604008394 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604008395 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604008396 TM-ABC transporter signature motif; other site 713604008397 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604008398 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604008399 active site 713604008400 catalytic tetrad [active] 713604008401 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 713604008402 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 713604008403 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604008404 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604008405 putative sugar binding sites [chemical binding]; other site 713604008406 Q-X-W motif; other site 713604008407 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604008408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604008409 DNA-binding site [nucleotide binding]; DNA binding site 713604008410 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604008411 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604008412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008413 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604008414 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604008415 DNA binding site [nucleotide binding] 713604008416 domain linker motif; other site 713604008417 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604008418 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 713604008419 ligand binding site [chemical binding]; other site 713604008420 dimerization interface (open form) [polypeptide binding]; other site 713604008421 dimerization interface (closed form) [polypeptide binding]; other site 713604008422 acyl-CoA synthetase; Validated; Region: PRK07788 713604008423 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008424 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604008425 putative AMP binding site [chemical binding]; other site 713604008426 putative active site [active] 713604008427 acyl-activating enzyme (AAE) consensus motif; other site 713604008428 putative CoA binding site [chemical binding]; other site 713604008429 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604008430 Lsr2; Region: Lsr2; pfam11774 713604008431 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008432 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604008433 acyl-activating enzyme (AAE) consensus motif; other site 713604008434 AMP binding site [chemical binding]; other site 713604008435 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008436 Condensation domain; Region: Condensation; pfam00668 713604008437 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008438 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008439 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008440 acyl-activating enzyme (AAE) consensus motif; other site 713604008441 AMP binding site [chemical binding]; other site 713604008442 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008443 Condensation domain; Region: Condensation; pfam00668 713604008444 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008445 Condensation domain; Region: Condensation; pfam00668 713604008446 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008447 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008448 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 713604008449 acyl-activating enzyme (AAE) consensus motif; other site 713604008450 AMP binding site [chemical binding]; other site 713604008451 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008452 Condensation domain; Region: Condensation; pfam00668 713604008453 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008454 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008455 Condensation domain; Region: Condensation; pfam00668 713604008456 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008457 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008458 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008459 acyl-activating enzyme (AAE) consensus motif; other site 713604008460 AMP binding site [chemical binding]; other site 713604008461 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008462 Condensation domain; Region: Condensation; pfam00668 713604008463 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008464 Condensation domain; Region: Condensation; pfam00668 713604008465 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008466 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008467 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008468 acyl-activating enzyme (AAE) consensus motif; other site 713604008469 AMP binding site [chemical binding]; other site 713604008470 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008471 MbtH-like protein; Region: MbtH; cl01279 713604008472 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604008473 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604008474 peptide synthase; Provisional; Region: PRK12316 713604008475 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008476 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008477 acyl-activating enzyme (AAE) consensus motif; other site 713604008478 AMP binding site [chemical binding]; other site 713604008479 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008480 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008481 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008482 acyl-activating enzyme (AAE) consensus motif; other site 713604008483 AMP binding site [chemical binding]; other site 713604008484 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008485 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008486 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008487 acyl-activating enzyme (AAE) consensus motif; other site 713604008488 AMP binding site [chemical binding]; other site 713604008489 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008490 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008491 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008492 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008493 acyl-activating enzyme (AAE) consensus motif; other site 713604008494 AMP binding site [chemical binding]; other site 713604008495 active site 713604008496 CoA binding site [chemical binding]; other site 713604008497 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008498 Condensation domain; Region: Condensation; pfam00668 713604008499 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008500 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008501 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008502 acyl-activating enzyme (AAE) consensus motif; other site 713604008503 AMP binding site [chemical binding]; other site 713604008504 active site 713604008505 CoA binding site [chemical binding]; other site 713604008506 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008507 Condensation domain; Region: Condensation; pfam00668 713604008508 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008509 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604008510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008511 putative substrate translocation pore; other site 713604008512 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604008513 Cytochrome P450; Region: p450; cl12078 713604008514 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604008515 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604008516 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604008517 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604008518 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604008519 putative NAD(P) binding site [chemical binding]; other site 713604008520 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604008521 Zn2+ binding site [ion binding]; other site 713604008522 Mg2+ binding site [ion binding]; other site 713604008523 Chitin binding domain; Region: Chitin_bind_3; pfam03067 713604008524 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604008525 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 713604008526 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 713604008527 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 713604008528 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604008529 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604008530 DNA binding residues [nucleotide binding] 713604008531 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 713604008532 putative hydrophobic ligand binding site [chemical binding]; other site 713604008533 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604008534 anti sigma factor interaction site; other site 713604008535 regulatory phosphorylation site [posttranslational modification]; other site 713604008536 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 713604008537 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604008538 active site 713604008539 metal binding site [ion binding]; metal-binding site 713604008540 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 713604008541 active site 713604008542 catalytic triad [active] 713604008543 oxyanion hole [active] 713604008544 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604008545 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604008546 NAD(P) binding site [chemical binding]; other site 713604008547 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 713604008548 classical (c) SDRs; Region: SDR_c; cd05233 713604008549 NAD(P) binding site [chemical binding]; other site 713604008550 active site 713604008551 classical (c) SDRs; Region: SDR_c; cd05233 713604008552 NAD(P) binding site [chemical binding]; other site 713604008553 active site 713604008554 RibD C-terminal domain; Region: RibD_C; cl17279 713604008555 enoyl-CoA hydratase; Provisional; Region: PRK06210 713604008556 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604008557 substrate binding site [chemical binding]; other site 713604008558 oxyanion hole (OAH) forming residues; other site 713604008559 trimer interface [polypeptide binding]; other site 713604008560 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 713604008561 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604008562 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604008563 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604008564 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604008565 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008566 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008567 acyl-activating enzyme (AAE) consensus motif; other site 713604008568 AMP binding site [chemical binding]; other site 713604008569 active site 713604008570 CoA binding site [chemical binding]; other site 713604008571 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 713604008572 active site 713604008573 substrate binding pocket [chemical binding]; other site 713604008574 homodimer interaction site [polypeptide binding]; other site 713604008575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008577 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604008578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604008579 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604008580 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 713604008581 active site 713604008582 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604008583 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 713604008584 active site 713604008585 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604008586 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 713604008587 FAD binding site [chemical binding]; other site 713604008588 substrate binding site [chemical binding]; other site 713604008589 catalytic base [active] 713604008590 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 713604008591 putative active site [active] 713604008592 putative substrate binding site [chemical binding]; other site 713604008593 ATP binding site [chemical binding]; other site 713604008594 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 713604008595 putative active site [active] 713604008596 putative catalytic site [active] 713604008597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604008598 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 713604008599 NAD(P) binding site [chemical binding]; other site 713604008600 active site 713604008601 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 713604008602 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604008603 active site pocket [active] 713604008604 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604008605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604008606 DNA-binding site [nucleotide binding]; DNA binding site 713604008607 FCD domain; Region: FCD; pfam07729 713604008608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604008609 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604008610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008611 dimer interface [polypeptide binding]; other site 713604008612 conserved gate region; other site 713604008613 putative PBP binding loops; other site 713604008614 ABC-ATPase subunit interface; other site 713604008615 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604008616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008617 dimer interface [polypeptide binding]; other site 713604008618 conserved gate region; other site 713604008619 putative PBP binding loops; other site 713604008620 ABC-ATPase subunit interface; other site 713604008621 hypothetical protein; Validated; Region: PRK08245 713604008622 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604008623 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604008624 active site 713604008625 ATP binding site [chemical binding]; other site 713604008626 substrate binding site [chemical binding]; other site 713604008627 activation loop (A-loop); other site 713604008628 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 713604008629 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604008630 DNA binding site [nucleotide binding] 713604008631 UbiA prenyltransferase family; Region: UbiA; pfam01040 713604008632 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 713604008633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604008634 Histidine kinase; Region: HisKA_3; pfam07730 713604008635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604008636 ATP binding site [chemical binding]; other site 713604008637 Mg2+ binding site [ion binding]; other site 713604008638 G-X-G motif; other site 713604008639 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604008640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604008641 active site 713604008642 phosphorylation site [posttranslational modification] 713604008643 intermolecular recognition site; other site 713604008644 dimerization interface [polypeptide binding]; other site 713604008645 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604008646 DNA binding residues [nucleotide binding] 713604008647 dimerization interface [polypeptide binding]; other site 713604008648 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604008649 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 713604008650 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604008651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008652 putative substrate translocation pore; other site 713604008653 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 713604008654 Zn binding site [ion binding]; other site 713604008655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604008656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604008657 dimerization interface [polypeptide binding]; other site 713604008658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604008659 dimer interface [polypeptide binding]; other site 713604008660 phosphorylation site [posttranslational modification] 713604008661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604008662 ATP binding site [chemical binding]; other site 713604008663 Mg2+ binding site [ion binding]; other site 713604008664 G-X-G motif; other site 713604008665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604008666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604008667 active site 713604008668 phosphorylation site [posttranslational modification] 713604008669 intermolecular recognition site; other site 713604008670 dimerization interface [polypeptide binding]; other site 713604008671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604008672 DNA binding site [nucleotide binding] 713604008673 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604008674 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604008675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604008676 Walker A/P-loop; other site 713604008677 ATP binding site [chemical binding]; other site 713604008678 Q-loop/lid; other site 713604008679 ABC transporter signature motif; other site 713604008680 Walker B; other site 713604008681 D-loop; other site 713604008682 H-loop/switch region; other site 713604008683 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604008684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604008685 NAD(P) binding site [chemical binding]; other site 713604008686 active site 713604008687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008689 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604008690 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604008691 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604008692 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604008693 Walker A/P-loop; other site 713604008694 ATP binding site [chemical binding]; other site 713604008695 Q-loop/lid; other site 713604008696 ABC transporter signature motif; other site 713604008697 Walker B; other site 713604008698 D-loop; other site 713604008699 H-loop/switch region; other site 713604008700 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 713604008701 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 713604008702 nucleotide binding pocket [chemical binding]; other site 713604008703 K-X-D-G motif; other site 713604008704 catalytic site [active] 713604008705 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 713604008706 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 713604008707 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604008708 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604008709 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 713604008710 catalytic residues [active] 713604008711 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 713604008712 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604008713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604008714 DNA binding residues [nucleotide binding] 713604008715 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 713604008716 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604008717 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604008718 HTH domain; Region: HTH_11; pfam08279 713604008719 WYL domain; Region: WYL; pfam13280 713604008720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604008721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008722 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 713604008723 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 713604008724 tetramer interface [polypeptide binding]; other site 713604008725 active site 713604008726 Mg2+/Mn2+ binding site [ion binding]; other site 713604008727 TIGR03086 family protein; Region: TIGR03086 713604008728 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604008729 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604008730 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604008731 DNA binding residues [nucleotide binding] 713604008732 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 713604008733 MarR family; Region: MarR_2; pfam12802 713604008734 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 713604008735 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 713604008736 active site 713604008737 catalytic site [active] 713604008738 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 713604008739 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 713604008740 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 713604008741 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604008742 putative ligand binding site [chemical binding]; other site 713604008743 putative NAD binding site [chemical binding]; other site 713604008744 catalytic site [active] 713604008745 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604008746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008747 dimer interface [polypeptide binding]; other site 713604008748 conserved gate region; other site 713604008749 putative PBP binding loops; other site 713604008750 ABC-ATPase subunit interface; other site 713604008751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008752 dimer interface [polypeptide binding]; other site 713604008753 conserved gate region; other site 713604008754 putative PBP binding loops; other site 713604008755 ABC-ATPase subunit interface; other site 713604008756 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604008757 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604008758 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 713604008759 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604008760 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604008761 dimerization interface [polypeptide binding]; other site 713604008762 ligand binding site [chemical binding]; other site 713604008763 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604008764 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604008765 active site 713604008766 ATP binding site [chemical binding]; other site 713604008767 substrate binding site [chemical binding]; other site 713604008768 activation loop (A-loop); other site 713604008769 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604008770 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604008771 DNA binding site [nucleotide binding] 713604008772 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604008773 dimerization interface [polypeptide binding]; other site 713604008774 ligand binding site [chemical binding]; other site 713604008775 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604008776 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 713604008777 active site 713604008778 ATP binding site [chemical binding]; other site 713604008779 substrate binding site [chemical binding]; other site 713604008780 activation loop (A-loop); other site 713604008781 Cellulose binding domain; Region: CBM_2; pfam00553 713604008782 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604008783 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604008784 active site 713604008785 ATP binding site [chemical binding]; other site 713604008786 substrate binding site [chemical binding]; other site 713604008787 activation loop (A-loop); other site 713604008788 Cellulose binding domain; Region: CBM_2; pfam00553 713604008789 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604008790 anti sigma factor interaction site; other site 713604008791 regulatory phosphorylation site [posttranslational modification]; other site 713604008792 Polysulphide reductase, NrfD; Region: NrfD; cl01295 713604008793 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 713604008794 4Fe-4S binding domain; Region: Fer4_6; pfam12837 713604008795 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604008796 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604008797 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604008798 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 713604008799 molybdopterin cofactor binding site; other site 713604008800 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604008801 benzoate transport; Region: 2A0115; TIGR00895 713604008802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008803 putative substrate translocation pore; other site 713604008804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008805 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604008806 anti sigma factor interaction site; other site 713604008807 regulatory phosphorylation site [posttranslational modification]; other site 713604008808 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604008809 DinB superfamily; Region: DinB_2; pfam12867 713604008810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604008811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604008812 non-specific DNA binding site [nucleotide binding]; other site 713604008813 salt bridge; other site 713604008814 sequence-specific DNA binding site [nucleotide binding]; other site 713604008815 Cupin domain; Region: Cupin_2; pfam07883 713604008816 Homeodomain-like domain; Region: HTH_23; pfam13384 713604008817 Winged helix-turn helix; Region: HTH_29; pfam13551 713604008818 Homeodomain-like domain; Region: HTH_32; pfam13565 713604008819 DDE superfamily endonuclease; Region: DDE_3; pfam13358 713604008820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 713604008821 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604008822 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604008823 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604008824 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 713604008825 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 713604008826 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 713604008827 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 713604008828 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604008829 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604008830 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604008831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604008832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 713604008833 dimerization interface [polypeptide binding]; other site 713604008834 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 713604008835 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 713604008836 putative Iron-sulfur protein interface [polypeptide binding]; other site 713604008837 proximal heme binding site [chemical binding]; other site 713604008838 distal heme binding site [chemical binding]; other site 713604008839 putative dimer interface [polypeptide binding]; other site 713604008840 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 713604008841 L-aspartate oxidase; Provisional; Region: PRK06175 713604008842 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 713604008843 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 713604008844 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 713604008845 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 713604008846 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604008847 dimerization interface [polypeptide binding]; other site 713604008848 putative DNA binding site [nucleotide binding]; other site 713604008849 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604008850 putative Zn2+ binding site [ion binding]; other site 713604008851 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 713604008852 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 713604008853 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604008854 MarR family; Region: MarR; pfam01047 713604008855 MarR family; Region: MarR_2; cl17246 713604008856 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 713604008857 Phosphoesterase family; Region: Phosphoesterase; pfam04185 713604008858 Domain of unknown function (DUF756); Region: DUF756; pfam05506 713604008859 Domain of unknown function (DUF756); Region: DUF756; pfam05506 713604008860 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 713604008861 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 713604008862 O-methyltransferase; Region: Methyltransf_2; pfam00891 713604008863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604008864 sequence-specific DNA binding site [nucleotide binding]; other site 713604008865 salt bridge; other site 713604008866 Cupin domain; Region: Cupin_2; pfam07883 713604008867 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 713604008868 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 713604008869 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604008870 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 713604008871 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 713604008872 dihydrodipicolinate synthase; Region: dapA; TIGR00674 713604008873 active site 713604008874 inhibitor site; inhibition site 713604008875 dimer interface [polypeptide binding]; other site 713604008876 catalytic residue [active] 713604008877 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 713604008878 Proline racemase; Region: Pro_racemase; pfam05544 713604008879 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604008880 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604008881 active site 713604008882 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604008883 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604008884 ligand binding site [chemical binding]; other site 713604008885 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604008886 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604008887 ligand binding site [chemical binding]; other site 713604008888 flexible hinge region; other site 713604008889 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 713604008890 substrate binding pocket [chemical binding]; other site 713604008891 substrate-Mg2+ binding site; other site 713604008892 aspartate-rich region 1; other site 713604008893 aspartate-rich region 2; other site 713604008894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604008895 S-adenosylmethionine binding site [chemical binding]; other site 713604008896 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604008897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008898 dimer interface [polypeptide binding]; other site 713604008899 conserved gate region; other site 713604008900 ABC-ATPase subunit interface; other site 713604008901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008902 dimer interface [polypeptide binding]; other site 713604008903 conserved gate region; other site 713604008904 putative PBP binding loops; other site 713604008905 ABC-ATPase subunit interface; other site 713604008906 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604008907 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604008908 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 713604008909 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 713604008910 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 713604008911 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 713604008912 active site 713604008913 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 713604008914 active site 713604008915 DNA binding site [nucleotide binding] 713604008916 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 713604008917 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 713604008918 DNA binding site [nucleotide binding] 713604008919 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 713604008920 nucleotide binding site [chemical binding]; other site 713604008921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008923 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604008924 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604008925 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604008926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604008927 S-adenosylmethionine binding site [chemical binding]; other site 713604008928 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 713604008929 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 713604008930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604008931 motif II; other site 713604008932 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 713604008933 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 713604008934 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 713604008935 active site 713604008936 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604008937 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604008938 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 713604008939 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008940 acyl-activating enzyme (AAE) consensus motif; other site 713604008941 AMP binding site [chemical binding]; other site 713604008942 active site 713604008943 CoA binding site [chemical binding]; other site 713604008944 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604008945 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604008946 substrate binding site [chemical binding]; other site 713604008947 oxyanion hole (OAH) forming residues; other site 713604008948 trimer interface [polypeptide binding]; other site 713604008949 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604008950 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008951 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604008952 acyl-activating enzyme (AAE) consensus motif; other site 713604008953 acyl-activating enzyme (AAE) consensus motif; other site 713604008954 putative AMP binding site [chemical binding]; other site 713604008955 putative active site [active] 713604008956 putative CoA binding site [chemical binding]; other site 713604008957 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 713604008958 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 713604008959 catalytic Zn binding site [ion binding]; other site 713604008960 NAD binding site [chemical binding]; other site 713604008961 structural Zn binding site [ion binding]; other site 713604008962 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604008963 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604008964 NAD(P) binding site [chemical binding]; other site 713604008965 catalytic residues [active] 713604008966 BNR repeat-like domain; Region: BNR_2; pfam13088 713604008967 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 713604008968 Asp-box motif; other site 713604008969 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604008970 anti sigma factor interaction site; other site 713604008971 regulatory phosphorylation site [posttranslational modification]; other site 713604008972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604008973 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604008974 NAD(P) binding site [chemical binding]; other site 713604008975 active site 713604008976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008978 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 713604008979 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 713604008980 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 713604008981 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604008982 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604008983 ATP binding site [chemical binding]; other site 713604008984 Mg2+ binding site [ion binding]; other site 713604008985 G-X-G motif; other site 713604008986 SET domain; Region: SET; cl02566 713604008987 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008988 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604008989 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008990 acyl-activating enzyme (AAE) consensus motif; other site 713604008991 AMP binding site [chemical binding]; other site 713604008992 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 713604008993 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604008994 putative trimer interface [polypeptide binding]; other site 713604008995 putative CoA binding site [chemical binding]; other site 713604008996 Cellulose binding domain; Region: CBM_2; pfam00553 713604008997 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 713604008998 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 713604008999 active site 713604009000 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 713604009001 substrate binding site [chemical binding]; other site 713604009002 active site 713604009003 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 713604009004 metal binding site [ion binding]; metal-binding site 713604009005 ligand binding site [chemical binding]; other site 713604009006 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604009007 CBD_II domain; Region: CBD_II; smart00637 713604009008 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 713604009009 active site 713604009010 catalytic triad [active] 713604009011 oxyanion hole [active] 713604009012 Cellulose binding domain; Region: CBM_2; pfam00553 713604009013 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 713604009014 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 713604009015 active site 713604009016 catalytic triad [active] 713604009017 oxyanion hole [active] 713604009018 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009019 putative sugar binding sites [chemical binding]; other site 713604009020 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009021 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009022 putative sugar binding sites [chemical binding]; other site 713604009023 Q-X-W motif; other site 713604009024 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 713604009025 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 713604009026 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009027 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009028 putative sugar binding sites [chemical binding]; other site 713604009029 Q-X-W motif; other site 713604009030 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604009031 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009032 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009033 putative sugar binding sites [chemical binding]; other site 713604009034 Q-X-W motif; other site 713604009035 Right handed beta helix region; Region: Beta_helix; pfam13229 713604009036 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009037 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009038 putative sugar binding sites [chemical binding]; other site 713604009039 Q-X-W motif; other site 713604009040 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604009041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604009042 DNA-binding site [nucleotide binding]; DNA binding site 713604009043 FCD domain; Region: FCD; pfam07729 713604009044 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 713604009045 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009046 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009047 putative sugar binding sites [chemical binding]; other site 713604009048 Q-X-W motif; other site 713604009049 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604009050 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604009051 DNA binding site [nucleotide binding] 713604009052 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 713604009053 putative dimerization interface [polypeptide binding]; other site 713604009054 putative ligand binding site [chemical binding]; other site 713604009055 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604009056 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009057 putative sugar binding sites [chemical binding]; other site 713604009058 Q-X-W motif; other site 713604009059 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604009060 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 713604009061 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009062 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009063 putative sugar binding sites [chemical binding]; other site 713604009064 Q-X-W motif; other site 713604009065 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 713604009066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009070 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604009071 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604009073 DNA binding residues [nucleotide binding] 713604009074 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604009075 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 713604009076 putative NAD(P) binding site [chemical binding]; other site 713604009077 active site 713604009078 thiamine pyrophosphate protein; Provisional; Region: PRK08273 713604009079 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 713604009080 PYR/PP interface [polypeptide binding]; other site 713604009081 dimer interface [polypeptide binding]; other site 713604009082 tetramer interface [polypeptide binding]; other site 713604009083 TPP binding site [chemical binding]; other site 713604009084 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604009085 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 713604009086 TPP-binding site [chemical binding]; other site 713604009087 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604009088 MarR family; Region: MarR_2; pfam12802 713604009089 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 713604009090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604009091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604009092 ATP binding site [chemical binding]; other site 713604009093 Mg2+ binding site [ion binding]; other site 713604009094 G-X-G motif; other site 713604009095 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 713604009096 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604009097 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 713604009098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604009099 DNA-binding site [nucleotide binding]; DNA binding site 713604009100 transcriptional regulator protein; Region: phnR; TIGR03337 713604009101 UTRA domain; Region: UTRA; pfam07702 713604009102 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 713604009103 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 713604009104 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 713604009105 active site 713604009106 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604009107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604009108 dimer interface [polypeptide binding]; other site 713604009109 conserved gate region; other site 713604009110 putative PBP binding loops; other site 713604009111 ABC-ATPase subunit interface; other site 713604009112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604009113 dimer interface [polypeptide binding]; other site 713604009114 conserved gate region; other site 713604009115 putative PBP binding loops; other site 713604009116 ABC-ATPase subunit interface; other site 713604009117 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604009118 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604009119 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 713604009120 active site 713604009121 catalytic residues [active] 713604009122 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 713604009123 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604009124 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 713604009125 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 713604009126 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604009127 catalytic residue [active] 713604009128 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604009129 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604009130 active site 713604009131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604009132 putative DNA binding site [nucleotide binding]; other site 713604009133 putative Zn2+ binding site [ion binding]; other site 713604009134 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 713604009135 Low molecular weight phosphatase family; Region: LMWPc; cl00105 713604009136 active site 713604009137 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604009138 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009139 active site 713604009140 Predicted ATPase [General function prediction only]; Region: COG3903 713604009141 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604009142 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604009143 DNA binding residues [nucleotide binding] 713604009144 dimerization interface [polypeptide binding]; other site 713604009145 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604009146 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604009147 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604009148 metal binding site [ion binding]; metal-binding site 713604009149 active site 713604009150 I-site; other site 713604009151 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604009152 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604009153 DNA binding site [nucleotide binding] 713604009154 domain linker motif; other site 713604009155 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604009156 dimerization interface [polypeptide binding]; other site 713604009157 ligand binding site [chemical binding]; other site 713604009158 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 713604009159 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 713604009160 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604009161 hydrophobic ligand binding site; other site 713604009162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009164 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604009165 active site 713604009166 substrate binding sites [chemical binding]; other site 713604009167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009168 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 713604009169 DNA-binding interface [nucleotide binding]; DNA binding site 713604009170 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604009171 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009172 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604009173 DNA binding residues [nucleotide binding] 713604009174 MarR family; Region: MarR; pfam01047 713604009175 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 713604009176 dimerization interface [polypeptide binding]; other site 713604009177 active site 713604009178 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 713604009179 active site 713604009180 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604009181 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 713604009182 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 713604009183 putative substrate binding site [chemical binding]; other site 713604009184 active site 713604009185 serine/threonine protein kinase; Provisional; Region: PRK14879 713604009186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009188 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604009189 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604009190 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604009191 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604009192 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604009193 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 713604009194 synthetase active site [active] 713604009195 NTP binding site [chemical binding]; other site 713604009196 metal binding site [ion binding]; metal-binding site 713604009197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009198 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604009199 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604009200 Cytochrome P450; Region: p450; cl12078 713604009201 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 713604009202 active site 713604009203 Zn binding site [ion binding]; other site 713604009204 LysE type translocator; Region: LysE; cl00565 713604009205 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 713604009206 HSP70 interaction site [polypeptide binding]; other site 713604009207 Nuclease-related domain; Region: NERD; pfam08378 713604009208 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604009209 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 713604009210 acyl-activating enzyme (AAE) consensus motif; other site 713604009211 AMP binding site [chemical binding]; other site 713604009212 active site 713604009213 CoA binding site [chemical binding]; other site 713604009214 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604009215 DinB superfamily; Region: DinB_2; pfam12867 713604009216 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 713604009217 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604009218 substrate binding pocket [chemical binding]; other site 713604009219 membrane-bound complex binding site; other site 713604009220 hinge residues; other site 713604009221 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 713604009222 active site 713604009223 catalytic residues [active] 713604009224 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604009225 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 713604009226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604009227 putative substrate translocation pore; other site 713604009228 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604009229 acyl-CoA synthetase; Validated; Region: PRK05850 713604009230 acyl-activating enzyme (AAE) consensus motif; other site 713604009231 active site 713604009232 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604009233 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604009234 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 713604009235 active site 713604009236 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604009237 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604009238 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604009239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009240 KR domain; Region: KR; pfam08659 713604009241 NAD(P) binding site [chemical binding]; other site 713604009242 active site 713604009243 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604009244 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 713604009245 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 713604009246 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 713604009247 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604009248 Putative esterase; Region: Esterase; pfam00756 713604009249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 713604009250 Secretory lipase; Region: LIP; pfam03583 713604009251 Secretory lipase; Region: LIP; pfam03583 713604009252 potential frameshift: common BLAST hit: gi|290962205|ref|YP_003493387.1| esterase 713604009253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009255 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604009256 short chain dehydrogenase; Provisional; Region: PRK07856 713604009257 classical (c) SDRs; Region: SDR_c; cd05233 713604009258 NAD(P) binding site [chemical binding]; other site 713604009259 active site 713604009260 short chain dehydrogenase; Provisional; Region: PRK07791 713604009261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009262 NAD(P) binding site [chemical binding]; other site 713604009263 active site 713604009264 enoyl-CoA hydratase; Provisional; Region: PRK06495 713604009265 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604009266 substrate binding site [chemical binding]; other site 713604009267 oxyanion hole (OAH) forming residues; other site 713604009268 trimer interface [polypeptide binding]; other site 713604009269 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 713604009270 Coenzyme A transferase; Region: CoA_trans; cl17247 713604009271 Nitronate monooxygenase; Region: NMO; pfam03060 713604009272 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 713604009273 FMN binding site [chemical binding]; other site 713604009274 substrate binding site [chemical binding]; other site 713604009275 putative catalytic residue [active] 713604009276 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 713604009277 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604009278 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604009279 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 713604009280 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604009281 dimer interface [polypeptide binding]; other site 713604009282 active site 713604009283 short chain dehydrogenase; Provisional; Region: PRK07831 713604009284 classical (c) SDRs; Region: SDR_c; cd05233 713604009285 NAD(P) binding site [chemical binding]; other site 713604009286 active site 713604009287 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009288 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 713604009289 active site 713604009290 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 713604009291 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604009292 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 713604009293 acyl-activating enzyme (AAE) consensus motif; other site 713604009294 putative AMP binding site [chemical binding]; other site 713604009295 putative active site [active] 713604009296 putative CoA binding site [chemical binding]; other site 713604009297 enoyl-CoA hydratase; Provisional; Region: PRK08290 713604009298 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604009299 substrate binding site [chemical binding]; other site 713604009300 oxyanion hole (OAH) forming residues; other site 713604009301 trimer interface [polypeptide binding]; other site 713604009302 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604009303 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009304 active site 713604009305 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604009306 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604009307 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009308 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 713604009309 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009310 active site 713604009311 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604009312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 713604009314 Putative zinc-finger; Region: zf-HC2; pfam13490 713604009315 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 713604009316 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604009317 putative metal binding site [ion binding]; other site 713604009318 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604009319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604009320 DNA-binding site [nucleotide binding]; DNA binding site 713604009321 FCD domain; Region: FCD; pfam07729 713604009322 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 713604009323 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604009324 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 713604009325 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 713604009326 active site 713604009327 substrate binding site [chemical binding]; other site 713604009328 Mg2+ binding site [ion binding]; other site 713604009329 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 713604009330 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604009331 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604009332 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009333 NAD(P) binding site [chemical binding]; other site 713604009334 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604009335 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604009336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604009337 dimerization interface [polypeptide binding]; other site 713604009338 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 713604009339 cyclase homology domain; Region: CHD; cd07302 713604009340 nucleotidyl binding site; other site 713604009341 metal binding site [ion binding]; metal-binding site 713604009342 dimer interface [polypeptide binding]; other site 713604009343 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 713604009344 Ferredoxin [Energy production and conversion]; Region: COG1146 713604009345 4Fe-4S binding domain; Region: Fer4; pfam00037 713604009346 ferredoxin-NADP+ reductase; Region: PLN02852 713604009347 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604009348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009350 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604009351 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 713604009352 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 713604009353 alpha-galactosidase; Region: PLN02808; cl17638 713604009354 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 713604009355 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009356 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009357 putative sugar binding sites [chemical binding]; other site 713604009358 Q-X-W motif; other site 713604009359 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604009360 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604009361 DNA binding site [nucleotide binding] 713604009362 domain linker motif; other site 713604009363 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604009364 dimerization interface [polypeptide binding]; other site 713604009365 ligand binding site [chemical binding]; other site 713604009366 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604009367 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604009368 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604009369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604009370 putative PBP binding loops; other site 713604009371 ABC-ATPase subunit interface; other site 713604009372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604009373 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604009374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 713604009375 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 713604009376 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009377 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009378 putative sugar binding sites [chemical binding]; other site 713604009379 Q-X-W motif; other site 713604009380 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009381 putative sugar binding sites [chemical binding]; other site 713604009382 Q-X-W motif; other site 713604009383 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009384 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 713604009385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 713604009386 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 713604009387 Ca binding site [ion binding]; other site 713604009388 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 713604009389 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 713604009390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009391 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 713604009392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604009393 putative substrate translocation pore; other site 713604009394 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604009395 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604009396 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604009397 nucleotide binding site [chemical binding]; other site 713604009398 amino acid transporter; Region: 2A0306; TIGR00909 713604009399 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604009400 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604009401 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604009402 N-acetylmannosamine kinase; Provisional; Region: PRK05082 713604009403 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604009404 nucleotide binding site [chemical binding]; other site 713604009405 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604009406 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604009407 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604009408 DNA binding site [nucleotide binding] 713604009409 domain linker motif; other site 713604009410 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604009411 ligand binding site [chemical binding]; other site 713604009412 dimerization interface [polypeptide binding]; other site 713604009413 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A; Region: PNGaseA; pfam12222 713604009414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604009415 S-adenosylmethionine binding site [chemical binding]; other site 713604009416 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604009417 Cytochrome P450; Region: p450; cl12078 713604009418 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 713604009419 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 713604009420 RibD C-terminal domain; Region: RibD_C; pfam01872 713604009421 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604009422 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 713604009423 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 713604009424 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 713604009425 probable active site [active] 713604009426 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604009427 MarR family; Region: MarR; pfam01047 713604009428 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 713604009429 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604009430 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 713604009431 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 713604009432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604009433 salt bridge; other site 713604009434 non-specific DNA binding site [nucleotide binding]; other site 713604009435 sequence-specific DNA binding site [nucleotide binding]; other site 713604009436 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604009437 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604009438 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 713604009439 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604009440 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 713604009441 putative active site [active] 713604009442 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604009443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009444 NAD(P) binding site [chemical binding]; other site 713604009445 active site 713604009446 acyl-CoA synthetase; Validated; Region: PRK06188 713604009447 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604009448 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604009449 putative active site [active] 713604009450 putative CoA binding site [chemical binding]; other site 713604009451 putative AMP binding site [chemical binding]; other site 713604009452 Survival protein SurE; Region: SurE; cl00448 713604009453 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604009454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604009455 DNA binding residues [nucleotide binding] 713604009456 Putative zinc-finger; Region: zf-HC2; pfam13490 713604009457 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604009458 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 713604009459 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009460 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 713604009461 NAD(P) binding site [chemical binding]; other site 713604009462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009463 NAD(P) binding site [chemical binding]; other site 713604009464 active site 713604009465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009467 D-glutamate deacylase; Validated; Region: PRK09061 713604009468 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604009469 active site 713604009470 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604009471 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 713604009472 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 713604009473 metal binding site [ion binding]; metal-binding site 713604009474 dimer interface [polypeptide binding]; other site 713604009475 Uncharacterized conserved protein [Function unknown]; Region: COG3375 713604009476 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 713604009477 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 713604009478 active site 713604009479 octamer interface [polypeptide binding]; other site 713604009480 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604009481 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604009482 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 713604009483 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 713604009484 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 713604009485 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604009486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604009487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604009488 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604009489 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604009490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604009491 Walker A/P-loop; other site 713604009492 ATP binding site [chemical binding]; other site 713604009493 Q-loop/lid; other site 713604009494 ABC transporter signature motif; other site 713604009495 Walker B; other site 713604009496 D-loop; other site 713604009497 H-loop/switch region; other site 713604009498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604009499 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604009500 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604009501 Walker A/P-loop; other site 713604009502 ATP binding site [chemical binding]; other site 713604009503 Q-loop/lid; other site 713604009504 ABC transporter signature motif; other site 713604009505 Walker B; other site 713604009506 D-loop; other site 713604009507 H-loop/switch region; other site 713604009508 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604009509 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 713604009510 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 713604009511 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 713604009512 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604009513 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604009514 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604009515 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604009516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604009517 putative substrate translocation pore; other site 713604009518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009519 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604009520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604009521 S-adenosylmethionine binding site [chemical binding]; other site 713604009522 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 713604009523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009524 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604009525 NAD(P) binding site [chemical binding]; other site 713604009526 active site 713604009527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604009528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604009529 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604009530 Cytochrome P450; Region: p450; cl12078 713604009531 LexA repressor; Validated; Region: PRK00215 713604009532 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 713604009533 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 713604009534 Catalytic site [active] 713604009535 Chitin binding domain; Region: Chitin_bind_3; pfam03067 713604009536 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604009537 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604009538 putative NAD(P) binding site [chemical binding]; other site 713604009539 glycoside hydrolase family 64: beta-1,3-glucanase B (GluB)-like; Region: GH64-GluB-like; cd09220 713604009540 substrate binding pocket [chemical binding]; other site 713604009541 catalytic residues [active] 713604009542 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 713604009543 metal binding site [ion binding]; metal-binding site 713604009544 ligand binding site [chemical binding]; other site 713604009545 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604009546 hydrophobic ligand binding site; other site 713604009547 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 713604009548 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 713604009549 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604009550 substrate binding site [chemical binding]; other site 713604009551 ATP binding site [chemical binding]; other site 713604009552 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 713604009553 active site 713604009554 intersubunit interface [polypeptide binding]; other site 713604009555 Zn2+ binding site [ion binding]; other site 713604009556 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 713604009557 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 713604009558 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 713604009559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009560 NAD(P) binding site [chemical binding]; other site 713604009561 active site 713604009562 Predicted permease; Region: DUF318; cl17795 713604009563 TIGR03943 family protein; Region: TIGR03943 713604009564 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 713604009565 NMT1/THI5 like; Region: NMT1; pfam09084 713604009566 AAA ATPase domain; Region: AAA_16; pfam13191 713604009567 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604009568 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604009569 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604009570 DNA binding residues [nucleotide binding] 713604009571 dimerization interface [polypeptide binding]; other site 713604009572 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 713604009573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009574 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 713604009575 NAD(P) binding site [chemical binding]; other site 713604009576 active site 713604009577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009579 acyl-CoA synthetase; Validated; Region: PRK06188 713604009580 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604009581 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604009582 putative active site [active] 713604009583 putative CoA binding site [chemical binding]; other site 713604009584 putative AMP binding site [chemical binding]; other site 713604009585 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604009586 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604009587 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 713604009588 classical (c) SDRs; Region: SDR_c; cd05233 713604009589 NAD(P) binding site [chemical binding]; other site 713604009590 active site 713604009591 Phosphopantetheine attachment site; Region: PP-binding; cl09936 713604009592 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 713604009593 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 713604009594 dimer interface [polypeptide binding]; other site 713604009595 active site 713604009596 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604009597 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604009598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 713604009599 DNA-binding site [nucleotide binding]; DNA binding site 713604009600 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604009601 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 713604009602 substrate binding site [chemical binding]; other site 713604009603 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604009604 hydrophobic ligand binding site; other site 713604009605 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009606 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 713604009607 NAD(P) binding site [chemical binding]; other site 713604009608 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 713604009609 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604009610 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604009611 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 713604009612 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604009613 AAA ATPase domain; Region: AAA_16; pfam13191 713604009614 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604009615 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604009616 DNA binding residues [nucleotide binding] 713604009617 dimerization interface [polypeptide binding]; other site 713604009618 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604009619 metal-binding site [ion binding] 713604009620 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 713604009621 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604009622 metal-binding site [ion binding] 713604009623 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604009624 Soluble P-type ATPase [General function prediction only]; Region: COG4087 713604009625 Peptidase family M48; Region: Peptidase_M48; cl12018 713604009626 Penicillinase repressor; Region: Pencillinase_R; cl17580 713604009627 Domain of unknown function (DUF305); Region: DUF305; pfam03713 713604009628 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604009629 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 713604009630 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 713604009631 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 713604009632 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604009633 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604009635 DNA binding residues [nucleotide binding] 713604009636 Putative zinc-finger; Region: zf-HC2; pfam13490 713604009637 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 713604009638 putative hydrophobic ligand binding site [chemical binding]; other site 713604009639 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604009640 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009642 TIGR01777 family protein; Region: yfcH 713604009643 NAD(P) binding site [chemical binding]; other site 713604009644 active site 713604009645 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 713604009646 SNF2 Helicase protein; Region: DUF3670; pfam12419 713604009647 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604009648 ATP binding site [chemical binding]; other site 713604009649 putative Mg++ binding site [ion binding]; other site 713604009650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604009651 nucleotide binding region [chemical binding]; other site 713604009652 ATP-binding site [chemical binding]; other site 713604009653 Uncharacterized conserved protein [Function unknown]; Region: COG4279 713604009654 AAA domain; Region: AAA_33; pfam13671 713604009655 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604009656 G1 box; other site 713604009657 GTP/Mg2+ binding site [chemical binding]; other site 713604009658 G2 box; other site 713604009659 Switch I region; other site 713604009660 Family description; Region: UvrD_C_2; pfam13538 713604009661 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604009662 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 713604009663 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604009664 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 713604009665 enterobactin exporter EntS; Provisional; Region: PRK10489 713604009666 hypothetical protein; Provisional; Region: PRK06185 713604009667 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604009668 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 713604009669 BNR repeat-like domain; Region: BNR_2; pfam13088 713604009670 BNR repeat-like domain; Region: BNR_2; pfam13088 713604009671 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 713604009672 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 713604009673 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 713604009674 active site 713604009675 FMN binding site [chemical binding]; other site 713604009676 substrate binding site [chemical binding]; other site 713604009677 3Fe-4S cluster binding site [ion binding]; other site 713604009678 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604009679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604009680 active site 713604009681 phosphorylation site [posttranslational modification] 713604009682 intermolecular recognition site; other site 713604009683 dimerization interface [polypeptide binding]; other site 713604009684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604009685 DNA binding site [nucleotide binding] 713604009686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604009687 HAMP domain; Region: HAMP; pfam00672 713604009688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604009689 dimer interface [polypeptide binding]; other site 713604009690 phosphorylation site [posttranslational modification] 713604009691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604009692 ATP binding site [chemical binding]; other site 713604009693 Mg2+ binding site [ion binding]; other site 713604009694 G-X-G motif; other site 713604009695 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 713604009696 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604009697 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604009698 Walker A/P-loop; other site 713604009699 ATP binding site [chemical binding]; other site 713604009700 Q-loop/lid; other site 713604009701 ABC transporter signature motif; other site 713604009702 Walker B; other site 713604009703 D-loop; other site 713604009704 H-loop/switch region; other site 713604009705 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 713604009706 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 713604009707 FtsX-like permease family; Region: FtsX; pfam02687 713604009708 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009709 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604009710 NAD(P) binding site [chemical binding]; other site 713604009711 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604009712 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604009713 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604009716 Histidine kinase; Region: HisKA_3; pfam07730 713604009717 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604009718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604009719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604009720 active site 713604009721 phosphorylation site [posttranslational modification] 713604009722 intermolecular recognition site; other site 713604009723 dimerization interface [polypeptide binding]; other site 713604009724 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604009725 DNA binding residues [nucleotide binding] 713604009726 dimerization interface [polypeptide binding]; other site 713604009727 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604009728 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604009729 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604009730 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604009731 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 713604009732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604009734 Histidine kinase; Region: HisKA_3; pfam07730 713604009735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604009736 Response regulator receiver domain; Region: Response_reg; pfam00072 713604009737 active site 713604009738 phosphorylation site [posttranslational modification] 713604009739 intermolecular recognition site; other site 713604009740 dimerization interface [polypeptide binding]; other site 713604009741 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 713604009742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009743 NAD(P) binding site [chemical binding]; other site 713604009744 active site 713604009745 ribonuclease; Region: Ribonuclease; pfam00545 713604009746 active site 713604009747 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 713604009748 putative hydrophobic ligand binding site [chemical binding]; other site 713604009749 protein interface [polypeptide binding]; other site 713604009750 gate; other site 713604009751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604009752 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604009753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009755 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 713604009756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009757 NAD(P) binding site [chemical binding]; other site 713604009758 active site 713604009759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009760 active site 713604009761 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 713604009762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009763 NAD(P) binding site [chemical binding]; other site 713604009764 active site 713604009765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604009766 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 713604009767 benzoyl-CoA-dihydrodiol lyase; Region: benzo_boxC; TIGR03222 713604009768 CHAT domain; Region: CHAT; cl17868 713604009769 AAA domain; Region: AAA_22; pfam13401 713604009770 CHAT domain; Region: CHAT; cl17868 713604009771 SIR2-like domain; Region: SIR2_2; pfam13289 713604009772 DYW family of nucleic acid deaminases; Region: DYW_deaminase; pfam14432 713604009773 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604009774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009775 NAD(P) binding site [chemical binding]; other site 713604009776 active site 713604009777 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 713604009778 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604009779 Cytochrome P450; Region: p450; cl12078 713604009780 MarR family; Region: MarR_2; pfam12802 713604009781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 713604009782 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009783 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604009784 putative sugar binding sites [chemical binding]; other site 713604009785 Q-X-W motif; other site 713604009786 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009787 putative sugar binding sites [chemical binding]; other site 713604009788 Q-X-W motif; other site 713604009789 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009790 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604009791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604009792 active site 713604009793 phosphorylation site [posttranslational modification] 713604009794 intermolecular recognition site; other site 713604009795 dimerization interface [polypeptide binding]; other site 713604009796 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604009797 DNA binding site [nucleotide binding] 713604009798 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604009799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604009800 ATP binding site [chemical binding]; other site 713604009801 Mg2+ binding site [ion binding]; other site 713604009802 G-X-G motif; other site 713604009803 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 713604009804 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 713604009805 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 713604009806 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604009807 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604009808 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 713604009809 NodB motif; other site 713604009810 active site 713604009811 catalytic site [active] 713604009812 metal binding site [ion binding]; metal-binding site 713604009813 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604009814 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604009815 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604009816 ATP binding site [chemical binding]; other site 713604009817 Mg2+ binding site [ion binding]; other site 713604009818 G-X-G motif; other site 713604009819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604009820 PAS domain; Region: PAS_9; pfam13426 713604009821 putative active site [active] 713604009822 heme pocket [chemical binding]; other site 713604009823 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 713604009824 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 713604009825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604009826 S-adenosylmethionine binding site [chemical binding]; other site 713604009827 PAS domain; Region: PAS_9; pfam13426 713604009828 CheB methylesterase; Region: CheB_methylest; pfam01339 713604009829 hypothetical protein; Provisional; Region: PRK07236 713604009830 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 713604009831 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604009832 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604009833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604009835 TPR motif; other site 713604009836 binding surface 713604009837 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604009838 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604009839 putative NAD(P) binding site [chemical binding]; other site 713604009840 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009841 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009842 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 713604009843 alanine dehydrogenase; Region: alaDH; TIGR00518 713604009844 putative active site [active] 713604009845 putative ligand binding site [chemical binding]; other site 713604009846 putative NAD(P) binding site [chemical binding]; other site 713604009847 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 713604009848 active site clefts [active] 713604009849 zinc binding site [ion binding]; other site 713604009850 dimer interface [polypeptide binding]; other site 713604009851 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604009852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009854 WHG domain; Region: WHG; pfam13305 713604009855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009857 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604009858 Cupin domain; Region: Cupin_2; pfam07883 713604009859 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604009860 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 713604009861 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604009862 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604009863 anti sigma factor interaction site; other site 713604009864 regulatory phosphorylation site [posttranslational modification]; other site 713604009865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009867 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604009868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009869 NAD(P) binding site [chemical binding]; other site 713604009870 active site 713604009871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 713604009872 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604009873 WD40 repeats; Region: WD40; smart00320 713604009874 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 713604009875 structural tetrad; other site 713604009876 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604009877 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 713604009878 structural tetrad; other site 713604009879 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604009880 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604009881 DNA binding residues [nucleotide binding] 713604009882 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604009883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009884 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604009885 DNA binding residues [nucleotide binding] 713604009886 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604009887 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 713604009888 classical (c) SDRs; Region: SDR_c; cd05233 713604009889 NAD(P) binding site [chemical binding]; other site 713604009890 active site 713604009891 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604009892 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 713604009893 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604009894 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604009895 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 713604009896 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604009897 active site 713604009898 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604009899 Peptidase M15; Region: Peptidase_M15_3; cl01194 713604009900 Helix-turn-helix domain; Region: HTH_31; pfam13560 713604009901 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 713604009902 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604009903 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604009904 DNA binding site [nucleotide binding] 713604009905 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604009906 AAA ATPase domain; Region: AAA_16; pfam13191 713604009907 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604009908 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604009909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604009910 TPR motif; other site 713604009911 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604009912 binding surface 713604009913 NTPase; Region: NTPase_1; cl17478 713604009914 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604009915 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604009916 DNA binding residues [nucleotide binding] 713604009917 dimerization interface [polypeptide binding]; other site 713604009918 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 713604009919 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604009920 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604009921 active site 713604009922 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009923 acyl carrier protein; Provisional; Region: PRK07639 713604009924 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 713604009925 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 713604009926 dimer interface [polypeptide binding]; other site 713604009927 active site 713604009928 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604009929 catalytic residues [active] 713604009930 substrate binding site [chemical binding]; other site 713604009931 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604009932 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 713604009933 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 713604009934 Condensation domain; Region: Condensation; pfam00668 713604009935 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604009936 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604009937 Walker A/P-loop; other site 713604009938 ATP binding site [chemical binding]; other site 713604009939 Q-loop/lid; other site 713604009940 ABC transporter signature motif; other site 713604009941 Walker B; other site 713604009942 D-loop; other site 713604009943 H-loop/switch region; other site 713604009944 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604009945 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604009946 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 713604009947 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 713604009948 Amidinotransferase; Region: Amidinotransf; cl12043 713604009949 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 713604009950 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 713604009951 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 713604009952 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604009953 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604009954 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604009955 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604009956 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 713604009957 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604009958 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604009959 catalytic loop [active] 713604009960 iron binding site [ion binding]; other site 713604009961 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604009962 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009963 alpha-galactosidase; Region: PLN02808; cl17638 713604009964 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 713604009965 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 713604009966 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604009967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009968 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604009969 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604009970 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604009971 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604009972 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604009973 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604009974 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604009975 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604009976 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604009977 classical (c) SDRs; Region: SDR_c; cd05233 713604009978 NAD(P) binding site [chemical binding]; other site 713604009979 active site 713604009980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604009981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604009982 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604009983 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604009984 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009985 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604009986 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604009987 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604009988 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604009989 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604009990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009992 WHG domain; Region: WHG; pfam13305 713604009993 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009995 WHG domain; Region: WHG; pfam13305 713604009996 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009997 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604009998 NAD(P) binding site [chemical binding]; other site 713604009999 Protein of unknown function (DUF998); Region: DUF998; pfam06197 713604010000 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604010001 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604010002 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604010003 dimerization interface [polypeptide binding]; other site 713604010004 putative DNA binding site [nucleotide binding]; other site 713604010005 putative Zn2+ binding site [ion binding]; other site 713604010006 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604010007 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604010008 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 713604010009 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 713604010010 putative dimerization interface [polypeptide binding]; other site 713604010011 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604010012 catalytic triad [active] 713604010013 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604010014 active site 713604010015 catalytic triad [active] 713604010016 oxyanion hole [active] 713604010017 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 713604010018 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 713604010019 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604010020 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 713604010021 substrate binding site [chemical binding]; other site 713604010022 active site 713604010023 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 713604010024 active site 713604010025 catalytic triad [active] 713604010026 oxyanion hole [active] 713604010027 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604010028 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604010029 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010030 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010031 putative sugar binding sites [chemical binding]; other site 713604010032 Q-X-W motif; other site 713604010033 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604010034 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 713604010035 active site 713604010036 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604010037 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604010038 Condensation domain; Region: Condensation; pfam00668 713604010039 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604010040 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604010041 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 713604010042 acyl-activating enzyme (AAE) consensus motif; other site 713604010043 AMP binding site [chemical binding]; other site 713604010044 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604010045 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604010046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604010047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604010048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604010049 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 713604010050 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604010051 acyl-activating enzyme (AAE) consensus motif; other site 713604010052 AMP binding site [chemical binding]; other site 713604010053 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604010054 Condensation domain; Region: Condensation; pfam00668 713604010055 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604010056 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604010057 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604010058 Condensation domain; Region: Condensation; pfam00668 713604010059 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604010060 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604010061 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010062 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 713604010063 acyl-activating enzyme (AAE) consensus motif; other site 713604010064 AMP binding site [chemical binding]; other site 713604010065 active site 713604010066 CoA binding site [chemical binding]; other site 713604010067 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604010068 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010069 ApbE family; Region: ApbE; pfam02424 713604010070 FMN-binding domain; Region: FMN_bind; cl01081 713604010071 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 713604010072 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 713604010073 FAD binding pocket [chemical binding]; other site 713604010074 FAD binding motif [chemical binding]; other site 713604010075 phosphate binding motif [ion binding]; other site 713604010076 beta-alpha-beta structure motif; other site 713604010077 NAD binding pocket [chemical binding]; other site 713604010078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604010079 dimerization interface [polypeptide binding]; other site 713604010080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604010081 dimer interface [polypeptide binding]; other site 713604010082 phosphorylation site [posttranslational modification] 713604010083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604010084 ATP binding site [chemical binding]; other site 713604010085 Mg2+ binding site [ion binding]; other site 713604010086 G-X-G motif; other site 713604010087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604010088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604010089 active site 713604010090 phosphorylation site [posttranslational modification] 713604010091 intermolecular recognition site; other site 713604010092 dimerization interface [polypeptide binding]; other site 713604010093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604010094 DNA binding site [nucleotide binding] 713604010095 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604010096 active site 713604010097 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 713604010098 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604010099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604010100 active site 713604010101 phosphorylation site [posttranslational modification] 713604010102 intermolecular recognition site; other site 713604010103 dimerization interface [polypeptide binding]; other site 713604010104 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604010105 DNA binding residues [nucleotide binding] 713604010106 dimerization interface [polypeptide binding]; other site 713604010107 Histidine kinase; Region: HisKA_3; pfam07730 713604010108 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604010109 hypothetical protein; Provisional; Region: PRK06184 713604010110 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604010111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604010112 S-adenosylmethionine binding site [chemical binding]; other site 713604010113 Transposase, Mutator family; Region: Transposase_mut; pfam00872 713604010114 Transposase, Mutator family; Region: Transposase_mut; pfam00872 713604010115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010117 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 713604010118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604010119 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 713604010120 NAD(P) binding site [chemical binding]; other site 713604010121 active site 713604010122 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604010123 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604010124 putative DNA binding site [nucleotide binding]; other site 713604010125 putative Zn2+ binding site [ion binding]; other site 713604010126 AsnC family; Region: AsnC_trans_reg; pfam01037 713604010127 EamA-like transporter family; Region: EamA; pfam00892 713604010128 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604010129 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604010130 putative NAD(P) binding site [chemical binding]; other site 713604010131 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604010132 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 713604010133 NmrA-like family; Region: NmrA; pfam05368 713604010134 NADP binding site [chemical binding]; other site 713604010135 active site 713604010136 regulatory binding site [polypeptide binding]; other site 713604010137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604010138 MarR family; Region: MarR; pfam01047 713604010139 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604010140 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604010141 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604010142 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 713604010143 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010144 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010145 putative sugar binding sites [chemical binding]; other site 713604010146 Q-X-W motif; other site 713604010147 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604010148 Interdomain contacts; other site 713604010149 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604010150 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604010151 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604010152 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 713604010153 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 713604010154 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604010155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604010156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604010157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604010158 salt bridge; other site 713604010159 non-specific DNA binding site [nucleotide binding]; other site 713604010160 sequence-specific DNA binding site [nucleotide binding]; other site 713604010161 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604010162 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604010163 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604010164 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 713604010165 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604010166 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604010167 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604010168 catalytic loop [active] 713604010169 iron binding site [ion binding]; other site 713604010170 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604010171 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604010172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604010173 putative substrate translocation pore; other site 713604010174 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 713604010175 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604010176 catalytic Zn binding site [ion binding]; other site 713604010177 NAD(P) binding site [chemical binding]; other site 713604010178 structural Zn binding site [ion binding]; other site 713604010179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604010180 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604010181 sequence-specific DNA binding site [nucleotide binding]; other site 713604010182 salt bridge; other site 713604010183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604010184 salt bridge; other site 713604010185 non-specific DNA binding site [nucleotide binding]; other site 713604010186 sequence-specific DNA binding site [nucleotide binding]; other site 713604010187 Uncharacterized conserved protein [Function unknown]; Region: COG4925 713604010188 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 713604010189 RibD C-terminal domain; Region: RibD_C; cl17279 713604010190 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 713604010191 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604010192 active site 713604010193 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604010194 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 713604010195 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 713604010196 WHG domain; Region: WHG; pfam13305 713604010197 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 713604010198 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604010199 dimerization interface [polypeptide binding]; other site 713604010200 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 713604010201 putative active cleft [active] 713604010202 MarR family; Region: MarR_2; pfam12802 713604010203 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604010204 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604010205 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 713604010206 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 713604010207 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 713604010208 substrate binding site [chemical binding]; other site 713604010209 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604010210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604010211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010212 putative PBP binding loops; other site 713604010213 dimer interface [polypeptide binding]; other site 713604010214 ABC-ATPase subunit interface; other site 713604010215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604010216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010217 dimer interface [polypeptide binding]; other site 713604010218 conserved gate region; other site 713604010219 putative PBP binding loops; other site 713604010220 ABC-ATPase subunit interface; other site 713604010221 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604010222 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 713604010223 Walker A/P-loop; other site 713604010224 ATP binding site [chemical binding]; other site 713604010225 Q-loop/lid; other site 713604010226 ABC transporter signature motif; other site 713604010227 Walker B; other site 713604010228 D-loop; other site 713604010229 H-loop/switch region; other site 713604010230 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604010231 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604010232 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604010233 Walker A/P-loop; other site 713604010234 ATP binding site [chemical binding]; other site 713604010235 Q-loop/lid; other site 713604010236 ABC transporter signature motif; other site 713604010237 Walker B; other site 713604010238 D-loop; other site 713604010239 H-loop/switch region; other site 713604010240 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604010241 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 713604010242 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604010243 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604010244 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604010245 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604010246 ligand binding site [chemical binding]; other site 713604010247 dimerization interface [polypeptide binding]; other site 713604010248 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010249 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010250 putative sugar binding sites [chemical binding]; other site 713604010251 Q-X-W motif; other site 713604010252 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 713604010253 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 713604010254 active site 713604010255 catalytic triad [active] 713604010256 oxyanion hole [active] 713604010257 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010258 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010259 putative sugar binding sites [chemical binding]; other site 713604010260 Q-X-W motif; other site 713604010261 MarR family; Region: MarR_2; cl17246 713604010262 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604010263 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604010264 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 713604010265 Melibiase; Region: Melibiase; pfam02065 713604010266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010267 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010268 active site 713604010269 Cupin; Region: Cupin_6; pfam12852 713604010270 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604010271 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604010272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604010273 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604010274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010275 hypothetical protein; Provisional; Region: PRK06126 713604010276 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604010277 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 713604010278 active site 713604010279 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 713604010280 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 713604010281 active site 713604010282 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604010283 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604010284 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604010285 DNA binding residues [nucleotide binding] 713604010286 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604010287 iron-sulfur cluster [ion binding]; other site 713604010288 [2Fe-2S] cluster binding site [ion binding]; other site 713604010289 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 713604010290 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 713604010291 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 713604010292 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 713604010293 active site 713604010294 catalytic triad [active] 713604010295 oxyanion hole [active] 713604010296 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604010297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604010298 active site 713604010299 phosphorylation site [posttranslational modification] 713604010300 intermolecular recognition site; other site 713604010301 dimerization interface [polypeptide binding]; other site 713604010302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604010303 DNA binding site [nucleotide binding] 713604010304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604010305 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604010306 dimerization interface [polypeptide binding]; other site 713604010307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604010308 dimer interface [polypeptide binding]; other site 713604010309 phosphorylation site [posttranslational modification] 713604010310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604010311 ATP binding site [chemical binding]; other site 713604010312 Mg2+ binding site [ion binding]; other site 713604010313 G-X-G motif; other site 713604010314 Acyltransferase family; Region: Acyl_transf_3; pfam01757 713604010315 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604010316 Methyltransferase domain; Region: Methyltransf_26; pfam13659 713604010317 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604010318 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604010319 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604010320 DNA binding residues [nucleotide binding] 713604010321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604010322 S-adenosylmethionine binding site [chemical binding]; other site 713604010323 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604010324 putative DNA binding site [nucleotide binding]; other site 713604010325 dimerization interface [polypeptide binding]; other site 713604010326 putative Zn2+ binding site [ion binding]; other site 713604010327 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 713604010328 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604010329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604010330 non-specific DNA binding site [nucleotide binding]; other site 713604010331 salt bridge; other site 713604010332 sequence-specific DNA binding site [nucleotide binding]; other site 713604010333 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 713604010334 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 713604010335 Acylphosphatase; Region: Acylphosphatase; pfam00708 713604010336 HypF finger; Region: zf-HYPF; pfam07503 713604010337 HypF finger; Region: zf-HYPF; pfam07503 713604010338 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 713604010339 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604010340 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 713604010341 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 713604010342 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 713604010343 dimerization interface [polypeptide binding]; other site 713604010344 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 713604010345 ATP binding site [chemical binding]; other site 713604010346 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 713604010347 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 713604010348 HupF/HypC family; Region: HupF_HypC; pfam01455 713604010349 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 713604010350 nickel binding site [ion binding]; other site 713604010351 NifU-like domain; Region: NifU; cl00484 713604010352 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 713604010353 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 713604010354 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 713604010355 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 713604010356 dimer interface [polypeptide binding]; other site 713604010357 active site 713604010358 HupF/HypC family; Region: HupF_HypC; cl00394 713604010359 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 713604010360 dimer interface [polypeptide binding]; other site 713604010361 active site 713604010362 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010363 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010364 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010365 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010366 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010367 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010368 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 713604010369 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 713604010370 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604010371 RHS Repeat; Region: RHS_repeat; pfam05593 713604010372 RHS Repeat; Region: RHS_repeat; pfam05593 713604010373 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604010374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604010375 NAD(P) binding site [chemical binding]; other site 713604010376 active site 713604010377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604010378 sequence-specific DNA binding site [nucleotide binding]; other site 713604010379 salt bridge; other site 713604010380 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604010381 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 713604010382 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604010383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604010384 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604010385 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604010386 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604010387 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010388 substrate binding site [chemical binding]; other site 713604010389 oxyanion hole (OAH) forming residues; other site 713604010390 trimer interface [polypeptide binding]; other site 713604010391 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 713604010392 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604010393 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604010394 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604010395 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604010396 putative NAD(P) binding site [chemical binding]; other site 713604010397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010399 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604010400 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604010401 putative NAD(P) binding site [chemical binding]; other site 713604010402 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604010403 classical (c) SDRs; Region: SDR_c; cd05233 713604010404 NAD(P) binding site [chemical binding]; other site 713604010405 active site 713604010406 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604010407 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604010408 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604010409 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 713604010410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604010411 NAD(P) binding site [chemical binding]; other site 713604010412 active site 713604010413 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604010414 classical (c) SDRs; Region: SDR_c; cd05233 713604010415 NAD(P) binding site [chemical binding]; other site 713604010416 active site 713604010417 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604010418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010420 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 713604010421 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010422 acyl-activating enzyme (AAE) consensus motif; other site 713604010423 active site 713604010424 AMP binding site [chemical binding]; other site 713604010425 CoA binding site [chemical binding]; other site 713604010426 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 713604010427 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 713604010428 putative ligand binding site [chemical binding]; other site 713604010429 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 713604010430 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604010431 TM-ABC transporter signature motif; other site 713604010432 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 713604010433 TM-ABC transporter signature motif; other site 713604010434 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604010435 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 713604010436 Walker A/P-loop; other site 713604010437 ATP binding site [chemical binding]; other site 713604010438 Q-loop/lid; other site 713604010439 ABC transporter signature motif; other site 713604010440 Walker B; other site 713604010441 D-loop; other site 713604010442 H-loop/switch region; other site 713604010443 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 713604010444 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 713604010445 Walker A/P-loop; other site 713604010446 ATP binding site [chemical binding]; other site 713604010447 Q-loop/lid; other site 713604010448 ABC transporter signature motif; other site 713604010449 Walker B; other site 713604010450 D-loop; other site 713604010451 H-loop/switch region; other site 713604010452 enoyl-CoA hydratase; Provisional; Region: PRK06210 713604010453 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010454 substrate binding site [chemical binding]; other site 713604010455 oxyanion hole (OAH) forming residues; other site 713604010456 trimer interface [polypeptide binding]; other site 713604010457 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010458 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 713604010459 FAD binding site [chemical binding]; other site 713604010460 substrate binding site [chemical binding]; other site 713604010461 catalytic base [active] 713604010462 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604010463 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010464 AMP binding site [chemical binding]; other site 713604010465 active site 713604010466 acyl-activating enzyme (AAE) consensus motif; other site 713604010467 CoA binding site [chemical binding]; other site 713604010468 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 713604010469 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 713604010470 active site 713604010471 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 713604010472 catalytic triad [active] 713604010473 dimer interface [polypeptide binding]; other site 713604010474 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604010475 active site 2 [active] 713604010476 active site 1 [active] 713604010477 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604010478 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010479 substrate binding site [chemical binding]; other site 713604010480 oxyanion hole (OAH) forming residues; other site 713604010481 trimer interface [polypeptide binding]; other site 713604010482 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010483 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010484 active site 713604010485 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 713604010486 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 713604010487 NAD binding site [chemical binding]; other site 713604010488 catalytic residues [active] 713604010489 Domain of unknown function (DUF222); Region: DUF222; pfam02720 713604010490 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604010491 active site 713604010492 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604010493 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604010494 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 713604010495 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604010496 dimer interface [polypeptide binding]; other site 713604010497 active site 713604010498 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 713604010499 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 713604010500 FMN binding site [chemical binding]; other site 713604010501 substrate binding site [chemical binding]; other site 713604010502 putative catalytic residue [active] 713604010503 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604010504 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 713604010505 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604010506 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604010507 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 713604010508 tetramerization interface [polypeptide binding]; other site 713604010509 NAD(P) binding site [chemical binding]; other site 713604010510 catalytic residues [active] 713604010511 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 713604010512 CoA binding domain; Region: CoA_binding_2; pfam13380 713604010513 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 713604010514 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 713604010515 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010516 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604010517 active site 713604010518 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 713604010519 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 713604010520 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 713604010521 active site 713604010522 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 713604010523 catalytic triad [active] 713604010524 dimer interface [polypeptide binding]; other site 713604010525 Amidohydrolase; Region: Amidohydro_2; pfam04909 713604010526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010528 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010529 active site 713604010530 Amidohydrolase; Region: Amidohydro_2; pfam04909 713604010531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010532 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 713604010533 DUF35 OB-fold domain; Region: DUF35; pfam01796 713604010534 lipid-transfer protein; Provisional; Region: PRK08256 713604010535 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604010536 active site 713604010537 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 713604010538 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604010539 NAD binding site [chemical binding]; other site 713604010540 homodimer interface [polypeptide binding]; other site 713604010541 homotetramer interface [polypeptide binding]; other site 713604010542 active site 713604010543 Predicted membrane protein [Function unknown]; Region: COG2259 713604010544 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 713604010545 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604010546 dimer interface [polypeptide binding]; other site 713604010547 active site 713604010548 enoyl-CoA hydratase; Provisional; Region: PRK08252 713604010549 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010550 substrate binding site [chemical binding]; other site 713604010551 oxyanion hole (OAH) forming residues; other site 713604010552 trimer interface [polypeptide binding]; other site 713604010553 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604010554 CoenzymeA binding site [chemical binding]; other site 713604010555 subunit interaction site [polypeptide binding]; other site 713604010556 PHB binding site; other site 713604010557 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604010558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604010559 short chain dehydrogenase; Provisional; Region: PRK07791 713604010560 NAD(P) binding site [chemical binding]; other site 713604010561 active site 713604010562 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604010563 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604010564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604010565 NAD(P) binding site [chemical binding]; other site 713604010566 active site 713604010567 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604010568 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010569 substrate binding site [chemical binding]; other site 713604010570 oxyanion hole (OAH) forming residues; other site 713604010571 trimer interface [polypeptide binding]; other site 713604010572 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604010573 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010574 substrate binding site [chemical binding]; other site 713604010575 oxyanion hole (OAH) forming residues; other site 713604010576 trimer interface [polypeptide binding]; other site 713604010577 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010578 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604010579 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604010580 active site 713604010581 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010582 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010583 active site 713604010584 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604010585 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010586 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010587 acyl-activating enzyme (AAE) consensus motif; other site 713604010588 acyl-activating enzyme (AAE) consensus motif; other site 713604010589 active site 713604010590 AMP binding site [chemical binding]; other site 713604010591 CoA binding site [chemical binding]; other site 713604010592 lipid-transfer protein; Provisional; Region: PRK07855 713604010593 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604010594 active site 713604010595 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 713604010596 DUF35 OB-fold domain; Region: DUF35; pfam01796 713604010597 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 713604010598 putative active site [active] 713604010599 putative catalytic site [active] 713604010600 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604010601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604010602 DNA-binding site [nucleotide binding]; DNA binding site 713604010603 FCD domain; Region: FCD; pfam07729 713604010604 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010605 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010606 active site 713604010607 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 713604010608 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 713604010609 conserved cys residue [active] 713604010610 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604010611 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 713604010612 NAD(P) binding site [chemical binding]; other site 713604010613 catalytic residues [active] 713604010614 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010615 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010616 active site 713604010617 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010618 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604010619 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604010620 active site 713604010621 enoyl-CoA hydratase; Provisional; Region: PRK08260 713604010622 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010623 substrate binding site [chemical binding]; other site 713604010624 oxyanion hole (OAH) forming residues; other site 713604010625 trimer interface [polypeptide binding]; other site 713604010626 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604010627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604010628 DNA-binding site [nucleotide binding]; DNA binding site 713604010629 FCD domain; Region: FCD; pfam07729 713604010630 short chain dehydrogenase; Provisional; Region: PRK06180 713604010631 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604010632 NADP binding site [chemical binding]; other site 713604010633 active site 713604010634 steroid binding site; other site 713604010635 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 713604010636 dihydropteroate synthase; Region: DHPS; TIGR01496 713604010637 substrate binding pocket [chemical binding]; other site 713604010638 dimer interface [polypeptide binding]; other site 713604010639 inhibitor binding site; inhibition site 713604010640 acyl-CoA synthetase; Validated; Region: PRK07798 713604010641 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010642 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 713604010643 acyl-activating enzyme (AAE) consensus motif; other site 713604010644 acyl-activating enzyme (AAE) consensus motif; other site 713604010645 putative AMP binding site [chemical binding]; other site 713604010646 putative active site [active] 713604010647 putative CoA binding site [chemical binding]; other site 713604010648 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604010649 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604010650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010651 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604010652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010654 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604010655 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 713604010656 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 713604010657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604010658 sequence-specific DNA binding site [nucleotide binding]; other site 713604010659 salt bridge; other site 713604010660 AAA ATPase domain; Region: AAA_16; pfam13191 713604010661 NB-ARC domain; Region: NB-ARC; pfam00931 713604010662 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 713604010663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604010664 TPR motif; other site 713604010665 binding surface 713604010666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604010667 TPR motif; other site 713604010668 binding surface 713604010669 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604010670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 713604010671 MOSC domain; Region: MOSC; pfam03473 713604010672 3-alpha domain; Region: 3-alpha; pfam03475 713604010673 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 713604010674 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 713604010675 FAD binding pocket [chemical binding]; other site 713604010676 FAD binding motif [chemical binding]; other site 713604010677 phosphate binding motif [ion binding]; other site 713604010678 beta-alpha-beta structure motif; other site 713604010679 NAD binding pocket [chemical binding]; other site 713604010680 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604010681 catalytic loop [active] 713604010682 iron binding site [ion binding]; other site 713604010683 dimerization interface [polypeptide binding]; other site 713604010684 putative DNA binding site [nucleotide binding]; other site 713604010685 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604010686 putative Zn2+ binding site [ion binding]; other site 713604010687 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604010688 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604010689 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 713604010690 hypothetical protein; Provisional; Region: PRK07907 713604010691 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 713604010692 active site 713604010693 metal binding site [ion binding]; metal-binding site 713604010694 dimer interface [polypeptide binding]; other site 713604010695 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 713604010696 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 713604010697 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604010698 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604010699 Short C-terminal domain; Region: SHOCT; pfam09851 713604010700 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604010701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604010702 DNA binding residues [nucleotide binding] 713604010703 dimerization interface [polypeptide binding]; other site 713604010704 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 713604010705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 713604010706 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 713604010707 Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399 713604010708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604010709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604010710 DNA binding residues [nucleotide binding] 713604010711 Domain of unknown function DUF20; Region: UPF0118; pfam01594 713604010712 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 713604010713 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 713604010714 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604010715 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604010716 alpha-galactosidase; Provisional; Region: PRK15076 713604010717 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 713604010718 NAD binding site [chemical binding]; other site 713604010719 sugar binding site [chemical binding]; other site 713604010720 divalent metal binding site [ion binding]; other site 713604010721 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604010722 dimer interface [polypeptide binding]; other site 713604010723 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604010724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010725 dimer interface [polypeptide binding]; other site 713604010726 conserved gate region; other site 713604010727 putative PBP binding loops; other site 713604010728 ABC-ATPase subunit interface; other site 713604010729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010730 dimer interface [polypeptide binding]; other site 713604010731 conserved gate region; other site 713604010732 putative PBP binding loops; other site 713604010733 ABC-ATPase subunit interface; other site 713604010734 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604010735 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604010736 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 713604010737 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 713604010738 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604010739 putative DNA binding site [nucleotide binding]; other site 713604010740 putative Zn2+ binding site [ion binding]; other site 713604010741 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604010742 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 713604010743 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 713604010744 dimer interface [polypeptide binding]; other site 713604010745 active site 713604010746 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 713604010747 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 713604010748 potential frameshift: common BLAST hit: gi|300785811|ref|YP_003766102.1| integral membrane protein 713604010749 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 713604010750 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604010751 ATP binding site [chemical binding]; other site 713604010752 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 713604010753 intersubunit interface [polypeptide binding]; other site 713604010754 active site 713604010755 zinc binding site [ion binding]; other site 713604010756 Na+ binding site [ion binding]; other site 713604010757 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604010758 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604010759 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010760 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010761 putative sugar binding sites [chemical binding]; other site 713604010762 Q-X-W motif; other site 713604010763 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604010764 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010765 acyl-activating enzyme (AAE) consensus motif; other site 713604010766 AMP binding site [chemical binding]; other site 713604010767 active site 713604010768 CoA binding site [chemical binding]; other site 713604010769 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604010770 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604010771 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604010772 active site 713604010773 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604010774 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604010775 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604010776 putative NADP binding site [chemical binding]; other site 713604010777 KR domain; Region: KR; pfam08659 713604010778 active site 713604010779 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604010780 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604010781 Cytochrome P450; Region: p450; cl12078 713604010782 Electron transfer DM13; Region: DM13; pfam10517 713604010783 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604010784 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 713604010785 NAD(P) binding site [chemical binding]; other site 713604010786 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604010787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604010788 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604010789 DNA binding residues [nucleotide binding] 713604010790 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 713604010791 endoglucanase; Region: PLN02308 713604010792 Cellulose binding domain; Region: CBM_3; smart01067 713604010793 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604010794 Interdomain contacts; other site 713604010795 Cytokine receptor motif; other site 713604010796 Cellulose binding domain; Region: CBM_3; pfam00942 713604010797 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 713604010798 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 713604010799 Putative Ig domain; Region: He_PIG; pfam05345 713604010800 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010801 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010802 putative sugar binding sites [chemical binding]; other site 713604010803 Q-X-W motif; other site 713604010804 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 713604010805 active site 713604010806 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604010807 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010808 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010809 putative sugar binding sites [chemical binding]; other site 713604010810 Q-X-W motif; other site 713604010811 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 713604010812 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604010813 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604010814 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604010815 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604010816 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 713604010817 active site 713604010818 substrate binding site [chemical binding]; other site 713604010819 cosubstrate binding site; other site 713604010820 catalytic site [active] 713604010821 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 713604010822 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010823 substrate binding site [chemical binding]; other site 713604010824 oxyanion hole (OAH) forming residues; other site 713604010825 trimer interface [polypeptide binding]; other site 713604010826 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604010827 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604010828 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604010829 AAA domain; Region: AAA_22; pfam13401 713604010830 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 713604010831 Catalytic site [active] 713604010832 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 713604010833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604010834 Walker A/P-loop; other site 713604010835 ATP binding site [chemical binding]; other site 713604010836 Q-loop/lid; other site 713604010837 ABC transporter signature motif; other site 713604010838 Walker B; other site 713604010839 D-loop; other site 713604010840 H-loop/switch region; other site 713604010841 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604010842 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604010843 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604010844 DNA binding residues [nucleotide binding] 713604010845 acyl-CoA synthetase; Validated; Region: PRK07867 713604010846 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 713604010847 acyl-activating enzyme (AAE) consensus motif; other site 713604010848 putative AMP binding site [chemical binding]; other site 713604010849 putative active site [active] 713604010850 putative CoA binding site [chemical binding]; other site 713604010851 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604010852 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604010853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010854 short chain dehydrogenase; Provisional; Region: PRK06197 713604010855 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 713604010856 putative NAD(P) binding site [chemical binding]; other site 713604010857 active site 713604010858 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 713604010859 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604010860 active site pocket [active] 713604010861 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604010862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010863 dimer interface [polypeptide binding]; other site 713604010864 conserved gate region; other site 713604010865 putative PBP binding loops; other site 713604010866 ABC-ATPase subunit interface; other site 713604010867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010868 dimer interface [polypeptide binding]; other site 713604010869 conserved gate region; other site 713604010870 putative PBP binding loops; other site 713604010871 ABC-ATPase subunit interface; other site 713604010872 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604010873 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604010874 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604010875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604010876 DNA-binding site [nucleotide binding]; DNA binding site 713604010877 FCD domain; Region: FCD; pfam07729 713604010878 Domain of unknown function (DUF718); Region: DUF718; pfam05336 713604010879 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604010880 active site 713604010881 TDP-binding site; other site 713604010882 acceptor substrate-binding pocket; other site 713604010883 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604010884 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604010885 active site 713604010886 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604010887 Cytochrome P450; Region: p450; cl12078 713604010888 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 713604010889 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 713604010890 active site 713604010891 iron coordination sites [ion binding]; other site 713604010892 substrate binding pocket [chemical binding]; other site 713604010893 potential frameshift: common BLAST hit: gi|300785851|ref|YP_003766142.1| non-ribosomal peptide synthetase/polyketide synthase 713604010894 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 713604010895 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604010896 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604010897 acyl-activating enzyme (AAE) consensus motif; other site 713604010898 AMP binding site [chemical binding]; other site 713604010899 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604010900 short chain dehydrogenase; Provisional; Region: PRK07041 713604010901 classical (c) SDRs; Region: SDR_c; cd05233 713604010902 NAD(P) binding site [chemical binding]; other site 713604010903 active site 713604010904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010906 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 713604010907 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 713604010908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604010909 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604010910 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604010911 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604010912 hypothetical protein; Validated; Region: PRK05868 713604010913 hypothetical protein; Provisional; Region: PRK07236 713604010914 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604010915 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604010916 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604010917 nucleotide binding site [chemical binding]; other site 713604010918 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604010919 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604010920 potential frameshift: common BLAST hit: gi|300785864|ref|YP_003766155.1| sugar ABC transporter ATPase 713604010921 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604010922 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604010923 TM-ABC transporter signature motif; other site 713604010924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 713604010925 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604010926 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604010927 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604010928 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604010929 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604010930 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 713604010931 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604010932 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 713604010933 putative NAD(P) binding site [chemical binding]; other site 713604010934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010936 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604010937 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604010938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010940 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010941 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010942 putative sugar binding sites [chemical binding]; other site 713604010943 Q-X-W motif; other site 713604010944 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 713604010945 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010946 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010947 putative sugar binding sites [chemical binding]; other site 713604010948 Q-X-W motif; other site 713604010949 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 713604010950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 713604010951 putative sugar binding sites [chemical binding]; other site 713604010952 Q-X-W motif; other site 713604010953 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 713604010954 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 713604010955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010957 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 713604010958 Cellulose binding domain; Region: CBM_2; pfam00553 713604010959 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 713604010960 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010961 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010962 putative sugar binding sites [chemical binding]; other site 713604010963 Q-X-W motif; other site 713604010964 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604010965 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010966 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010967 putative sugar binding sites [chemical binding]; other site 713604010968 Q-X-W motif; other site 713604010969 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604010970 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010971 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010972 putative sugar binding sites [chemical binding]; other site 713604010973 Q-X-W motif; other site 713604010974 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 713604010975 active site 713604010976 cinnamyl-alcohol dehydrogenase; Region: PLN02514 713604010977 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 713604010978 putative NAD(P) binding site [chemical binding]; other site 713604010979 putative substrate binding site [chemical binding]; other site 713604010980 catalytic Zn binding site [ion binding]; other site 713604010981 structural Zn binding site [ion binding]; other site 713604010982 dimer interface [polypeptide binding]; other site 713604010983 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010984 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010985 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604010986 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010987 acyl-activating enzyme (AAE) consensus motif; other site 713604010988 AMP binding site [chemical binding]; other site 713604010989 active site 713604010990 CoA binding site [chemical binding]; other site 713604010991 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604010992 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604010993 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604010994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604010995 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604010996 putative substrate translocation pore; other site 713604010997 Tannase and feruloyl esterase; Region: Tannase; pfam07519 713604010998 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604010999 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 713604011000 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604011001 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604011002 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 713604011003 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604011004 CBD_II domain; Region: CBD_II; smart00637 713604011005 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604011006 acyl carrier protein; Provisional; Region: acpP; PRK00982 713604011007 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 713604011008 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 713604011009 dimer interface [polypeptide binding]; other site 713604011010 active site 713604011011 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 713604011012 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 713604011013 dimer interface [polypeptide binding]; other site 713604011014 active site 713604011015 CoA binding pocket [chemical binding]; other site 713604011016 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 713604011017 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 713604011018 active site 713604011019 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604011020 Cytochrome P450; Region: p450; cl12078 713604011021 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604011022 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604011023 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604011024 acyl-activating enzyme (AAE) consensus motif; other site 713604011025 acyl-activating enzyme (AAE) consensus motif; other site 713604011026 AMP binding site [chemical binding]; other site 713604011027 active site 713604011028 CoA binding site [chemical binding]; other site 713604011029 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604011030 extended (e) SDRs; Region: SDR_e; cd08946 713604011031 NAD(P) binding site [chemical binding]; other site 713604011032 active site 713604011033 substrate binding site [chemical binding]; other site 713604011034 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604011035 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604011036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604011037 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604011038 dimerization interface [polypeptide binding]; other site 713604011039 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604011040 short chain dehydrogenase; Provisional; Region: PRK06523 713604011041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011042 NAD(P) binding site [chemical binding]; other site 713604011043 active site 713604011044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011045 NAD(P) binding site [chemical binding]; other site 713604011046 active site 713604011047 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604011048 MarR family; Region: MarR; pfam01047 713604011049 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604011050 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604011051 NB-ARC domain; Region: NB-ARC; pfam00931 713604011052 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604011053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604011054 binding surface 713604011055 TPR motif; other site 713604011056 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604011057 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604011058 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 713604011059 active site 713604011060 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 713604011061 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 713604011062 dimer interface [polypeptide binding]; other site 713604011063 active site 713604011064 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604011065 catalytic residues [active] 713604011066 substrate binding site [chemical binding]; other site 713604011067 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 713604011068 active site 713604011069 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604011070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604011071 active site 713604011072 phosphorylation site [posttranslational modification] 713604011073 intermolecular recognition site; other site 713604011074 dimerization interface [polypeptide binding]; other site 713604011075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604011076 DNA binding residues [nucleotide binding] 713604011077 dimerization interface [polypeptide binding]; other site 713604011078 Putative sensor; Region: Sensor; pfam13796 713604011079 Histidine kinase; Region: HisKA_3; pfam07730 713604011080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604011081 Mg2+ binding site [ion binding]; other site 713604011082 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604011083 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604011084 Walker A/P-loop; other site 713604011085 ATP binding site [chemical binding]; other site 713604011086 Q-loop/lid; other site 713604011087 ABC transporter signature motif; other site 713604011088 Walker B; other site 713604011089 D-loop; other site 713604011090 H-loop/switch region; other site 713604011091 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 713604011092 FtsX-like permease family; Region: FtsX; pfam02687 713604011093 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 713604011094 FtsX-like permease family; Region: FtsX; pfam02687 713604011095 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 713604011096 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604011097 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 713604011098 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 713604011099 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604011100 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604011101 active site 713604011102 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 713604011103 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604011104 dimer interface [polypeptide binding]; other site 713604011105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604011106 catalytic residue [active] 713604011107 Condensation domain; Region: Condensation; pfam00668 713604011108 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604011109 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604011110 acyl-activating enzyme (AAE) consensus motif; other site 713604011111 AMP binding site [chemical binding]; other site 713604011112 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011113 Condensation domain; Region: Condensation; pfam00668 713604011114 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604011115 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604011116 acyl-activating enzyme (AAE) consensus motif; other site 713604011117 AMP binding site [chemical binding]; other site 713604011118 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011119 Condensation domain; Region: Condensation; pfam00668 713604011120 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604011121 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604011122 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604011123 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604011124 active site 713604011125 CoA binding site [chemical binding]; other site 713604011126 AMP binding site [chemical binding]; other site 713604011127 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011128 Thioesterase domain; Region: Thioesterase; pfam00975 713604011129 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604011130 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604011131 MbtH-like protein; Region: MbtH; cl01279 713604011132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604011133 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604011134 Walker A/P-loop; other site 713604011135 ATP binding site [chemical binding]; other site 713604011136 Q-loop/lid; other site 713604011137 ABC transporter signature motif; other site 713604011138 Walker B; other site 713604011139 D-loop; other site 713604011140 H-loop/switch region; other site 713604011141 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 713604011142 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604011143 dimer interface [polypeptide binding]; other site 713604011144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604011145 catalytic residue [active] 713604011146 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 713604011147 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 713604011148 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604011149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011150 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 713604011151 NAD(P) binding site [chemical binding]; other site 713604011152 active site 713604011153 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 713604011154 active site 713604011155 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 713604011156 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 713604011157 dimer interface [polypeptide binding]; other site 713604011158 active site 713604011159 acyl carrier protein; Provisional; Region: acpP; PRK00982 713604011160 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604011161 DNA binding site [nucleotide binding] 713604011162 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604011163 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636 713604011164 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 713604011165 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 713604011166 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 713604011167 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 713604011168 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604011169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604011170 dimerization interface [polypeptide binding]; other site 713604011171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604011172 dimer interface [polypeptide binding]; other site 713604011173 phosphorylation site [posttranslational modification] 713604011174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604011175 ATP binding site [chemical binding]; other site 713604011176 Mg2+ binding site [ion binding]; other site 713604011177 G-X-G motif; other site 713604011178 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604011179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604011180 active site 713604011181 phosphorylation site [posttranslational modification] 713604011182 intermolecular recognition site; other site 713604011183 dimerization interface [polypeptide binding]; other site 713604011184 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604011185 DNA binding site [nucleotide binding] 713604011186 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604011187 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604011188 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 713604011189 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 713604011190 active site 713604011191 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604011192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604011193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604011194 dimerization interface [polypeptide binding]; other site 713604011195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011196 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604011197 NAD(P) binding site [chemical binding]; other site 713604011198 active site 713604011199 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604011200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604011201 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604011202 putative substrate translocation pore; other site 713604011203 PaaX-like protein; Region: PaaX; pfam07848 713604011204 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 713604011205 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 713604011206 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 713604011207 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604011208 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604011209 FkbH-like domain; Region: FkbH; TIGR01686 713604011210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604011211 active site 713604011212 motif I; other site 713604011213 motif II; other site 713604011214 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604011215 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604011216 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604011217 active site 713604011218 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011219 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604011220 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604011221 acyl-activating enzyme (AAE) consensus motif; other site 713604011222 AMP binding site [chemical binding]; other site 713604011223 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011224 Condensation domain; Region: Condensation; pfam00668 713604011225 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604011226 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604011227 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 713604011228 acyl-activating enzyme (AAE) consensus motif; other site 713604011229 AMP binding site [chemical binding]; other site 713604011230 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011231 Condensation domain; Region: Condensation; pfam00668 713604011232 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604011233 Condensation domain; Region: Condensation; pfam00668 713604011234 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604011235 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604011236 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011237 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604011238 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 713604011239 active site 713604011240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011241 Condensation domain; Region: Condensation; pfam00668 713604011242 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604011243 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604011244 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011245 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604011246 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 713604011247 active site 713604011248 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 713604011249 metal ion-dependent adhesion site (MIDAS); other site 713604011250 Calx-beta domain; Region: Calx-beta; pfam03160 713604011251 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 713604011252 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 713604011253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604011254 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 713604011255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604011256 S-adenosylmethionine binding site [chemical binding]; other site 713604011257 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 713604011258 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 713604011259 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 713604011260 active site lid residues [active] 713604011261 substrate binding pocket [chemical binding]; other site 713604011262 catalytic residues [active] 713604011263 substrate-Mg2+ binding site; other site 713604011264 aspartate-rich region 1; other site 713604011265 aspartate-rich region 2; other site 713604011266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604011267 phytoene desaturase; Region: crtI_fam; TIGR02734 713604011268 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 713604011269 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 713604011270 substrate binding pocket [chemical binding]; other site 713604011271 chain length determination region; other site 713604011272 substrate-Mg2+ binding site; other site 713604011273 catalytic residues [active] 713604011274 aspartate-rich region 1; other site 713604011275 active site lid residues [active] 713604011276 aspartate-rich region 2; other site 713604011277 Protein of unknown function (DUF422); Region: DUF422; cl00991 713604011278 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 713604011279 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 713604011280 active site 713604011281 phytoene desaturase; Region: crtI_fam; TIGR02734 713604011282 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 713604011283 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 713604011284 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604011285 DNA binding residues [nucleotide binding] 713604011286 B12 binding domain; Region: B12-binding_2; cl03653 713604011287 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 713604011288 B12 binding site [chemical binding]; other site 713604011289 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604011290 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 713604011291 DNA binding residues [nucleotide binding] 713604011292 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 713604011293 iron-sulfur cluster [ion binding]; other site 713604011294 [2Fe-2S] cluster binding site [ion binding]; other site 713604011295 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604011296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604011297 dimer interface [polypeptide binding]; other site 713604011298 conserved gate region; other site 713604011299 putative PBP binding loops; other site 713604011300 ABC-ATPase subunit interface; other site 713604011301 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 713604011302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604011303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604011304 dimer interface [polypeptide binding]; other site 713604011305 ABC-ATPase subunit interface; other site 713604011306 putative PBP binding loops; other site 713604011307 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604011308 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604011309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604011310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604011311 DNA binding site [nucleotide binding] 713604011312 domain linker motif; other site 713604011313 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604011314 dimerization interface [polypeptide binding]; other site 713604011315 ligand binding site [chemical binding]; other site 713604011316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604011317 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604011318 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604011319 Cellulose binding domain; Region: CBM_2; pfam00553 713604011320 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604011321 TIGR03086 family protein; Region: TIGR03086 713604011322 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604011323 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 713604011324 putative hydrophobic ligand binding site [chemical binding]; other site 713604011325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604011326 dimerization interface [polypeptide binding]; other site 713604011327 putative DNA binding site [nucleotide binding]; other site 713604011328 putative Zn2+ binding site [ion binding]; other site 713604011329 Cellulose binding domain; Region: CBM_2; pfam00553 713604011330 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604011331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011332 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 713604011333 NAD(P) binding site [chemical binding]; other site 713604011334 active site 713604011335 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604011336 PAS fold; Region: PAS_3; pfam08447 713604011337 putative active site [active] 713604011338 heme pocket [chemical binding]; other site 713604011339 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604011340 GAF domain; Region: GAF; pfam01590 713604011341 PAS domain S-box; Region: sensory_box; TIGR00229 713604011342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604011343 putative active site [active] 713604011344 heme pocket [chemical binding]; other site 713604011345 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604011346 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604011347 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604011348 ATP binding site [chemical binding]; other site 713604011349 Mg2+ binding site [ion binding]; other site 713604011350 G-X-G motif; other site 713604011351 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604011352 regulatory phosphorylation site [posttranslational modification]; other site 713604011353 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604011354 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604011355 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 713604011356 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 713604011357 Alginate lyase; Region: Alginate_lyase2; pfam08787 713604011358 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 713604011359 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 713604011360 dimer interface [polypeptide binding]; other site 713604011361 active site 713604011362 heme binding site [chemical binding]; other site 713604011363 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 713604011364 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 713604011365 metal binding site 2 [ion binding]; metal-binding site 713604011366 putative DNA binding helix; other site 713604011367 metal binding site 1 [ion binding]; metal-binding site 713604011368 dimer interface [polypeptide binding]; other site 713604011369 structural Zn2+ binding site [ion binding]; other site 713604011370 thymidylate synthase; Reviewed; Region: thyA; PRK01827 713604011371 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 713604011372 dimerization interface [polypeptide binding]; other site 713604011373 active site 713604011374 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604011375 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 713604011376 folate binding site [chemical binding]; other site 713604011377 NADP+ binding site [chemical binding]; other site 713604011378 choline dehydrogenase; Region: betA; TIGR01810 713604011379 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604011380 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 713604011381 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 713604011382 NAD(P) binding site [chemical binding]; other site 713604011383 catalytic residues [active] 713604011384 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 713604011385 catalytic site [active] 713604011386 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 713604011387 PLD-like domain; Region: PLDc_2; pfam13091 713604011388 putative active site [active] 713604011389 catalytic site [active] 713604011390 NACHT domain; Region: NACHT; pfam05729 713604011391 AAA ATPase domain; Region: AAA_16; pfam13191 713604011392 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 713604011393 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 713604011394 FMN-binding pocket [chemical binding]; other site 713604011395 flavin binding motif; other site 713604011396 phosphate binding motif [ion binding]; other site 713604011397 beta-alpha-beta structure motif; other site 713604011398 NAD binding pocket [chemical binding]; other site 713604011399 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604011400 catalytic loop [active] 713604011401 iron binding site [ion binding]; other site 713604011402 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 713604011403 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 713604011404 iron-sulfur cluster [ion binding]; other site 713604011405 [2Fe-2S] cluster binding site [ion binding]; other site 713604011406 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604011407 hydrophobic ligand binding site; other site 713604011408 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604011409 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604011410 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604011411 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 713604011412 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 713604011413 homodimer interface [polypeptide binding]; other site 713604011414 putative substrate binding pocket [chemical binding]; other site 713604011415 diiron center [ion binding]; other site 713604011416 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 713604011417 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 713604011418 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 713604011419 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 713604011420 RNase_H superfamily; Region: RNase_H_2; pfam13482 713604011421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604011422 AAA domain; Region: AAA_11; pfam13086 713604011423 Walker A motif; other site 713604011424 ATP binding site [chemical binding]; other site 713604011425 AAA domain; Region: AAA_12; pfam13087 713604011426 short chain dehydrogenase; Provisional; Region: PRK07109 713604011427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011428 NAD(P) binding site [chemical binding]; other site 713604011429 active site 713604011430 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 713604011431 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604011432 putative metal binding site [ion binding]; other site 713604011433 ChaB; Region: ChaB; pfam06150 713604011434 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 713604011435 CheB methylesterase; Region: CheB_methylest; pfam01339 713604011436 CheB methylesterase; Region: CheB_methylest; pfam01339 713604011437 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604011438 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604011439 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 713604011440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604011441 S-adenosylmethionine binding site [chemical binding]; other site 713604011442 PAS fold; Region: PAS; pfam00989 713604011443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 713604011444 putative active site [active] 713604011445 heme pocket [chemical binding]; other site 713604011446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604011447 PAS domain; Region: PAS_9; pfam13426 713604011448 putative active site [active] 713604011449 heme pocket [chemical binding]; other site 713604011450 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604011451 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 713604011452 active site 713604011453 HIGH motif; other site 713604011454 nucleotide binding site [chemical binding]; other site 713604011455 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604011456 active site 713604011457 KMSKS motif; other site 713604011458 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 713604011459 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604011460 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604011461 ATP binding site [chemical binding]; other site 713604011462 Mg2+ binding site [ion binding]; other site 713604011463 G-X-G motif; other site 713604011464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604011465 putative substrate translocation pore; other site 713604011466 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 713604011467 Uncharacterized conserved protein [Function unknown]; Region: COG4198 713604011468 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 713604011469 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604011470 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 713604011471 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 713604011472 active site 713604011473 DNA binding site [nucleotide binding] 713604011474 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 713604011475 DNA binding site [nucleotide binding] 713604011476 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 713604011477 nucleotide binding site [chemical binding]; other site 713604011478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604011479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604011480 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 713604011481 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 713604011482 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 713604011483 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 713604011484 active site 713604011485 dimer interface [polypeptide binding]; other site 713604011486 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 713604011487 putative sialic acid transporter; Region: 2A0112; TIGR00891 713604011488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604011489 putative substrate translocation pore; other site 713604011490 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 713604011491 catalytic site [active] 713604011492 BNR repeat-like domain; Region: BNR_2; pfam13088 713604011493 Asp-box motif; other site 713604011494 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 713604011495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604011496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604011497 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 713604011498 putative dimerization interface [polypeptide binding]; other site 713604011499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604011500 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604011501 dimerization interface [polypeptide binding]; other site 713604011502 substrate binding pocket [chemical binding]; other site 713604011503 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 713604011504 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604011505 putative NAD(P) binding site [chemical binding]; other site 713604011506 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604011507 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604011508 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604011509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604011510 S-adenosylmethionine binding site [chemical binding]; other site 713604011511 Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226 713604011512 putative active site [active] 713604011513 Zn binding site [ion binding]; other site 713604011514 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 713604011515 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604011516 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604011517 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 713604011518 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604011519 carboxyltransferase (CT) interaction site; other site 713604011520 biotinylation site [posttranslational modification]; other site 713604011521 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 713604011522 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 713604011523 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 713604011524 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 713604011525 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 713604011526 active site 713604011527 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604011528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604011529 DNA-binding site [nucleotide binding]; DNA binding site 713604011530 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604011531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604011532 homodimer interface [polypeptide binding]; other site 713604011533 catalytic residue [active] 713604011534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604011535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604011536 putative substrate translocation pore; other site 713604011537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604011538 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604011539 hydrophobic ligand binding site; other site 713604011540 Bifunctional nuclease; Region: DNase-RNase; pfam02577 713604011541 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604011542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604011543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604011544 DNA binding residues [nucleotide binding] 713604011545 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604011546 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 713604011547 acyl-CoA synthetase; Validated; Region: PRK05850 713604011548 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604011549 acyl-activating enzyme (AAE) consensus motif; other site 713604011550 active site 713604011551 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 713604011552 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604011553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604011554 S-adenosylmethionine binding site [chemical binding]; other site 713604011555 Hemerythrin-like domain; Region: Hr-like; cd12108 713604011556 Fe binding site [ion binding]; other site 713604011557 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 713604011558 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 713604011559 nucleotide binding site [chemical binding]; other site 713604011560 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604011561 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604011562 substrate binding site [chemical binding]; other site 713604011563 ATP binding site [chemical binding]; other site 713604011564 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 713604011565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604011566 ATP binding site [chemical binding]; other site 713604011567 putative Mg++ binding site [ion binding]; other site 713604011568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604011569 nucleotide binding region [chemical binding]; other site 713604011570 ATP-binding site [chemical binding]; other site 713604011571 ANTAR domain; Region: ANTAR; pfam03861 713604011572 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604011573 anti sigma factor interaction site; other site 713604011574 regulatory phosphorylation site [posttranslational modification]; other site 713604011575 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604011576 GAF domain; Region: GAF; pfam01590 713604011577 GAF domain; Region: GAF_2; pfam13185 713604011578 ANTAR domain; Region: ANTAR; pfam03861 713604011579 GAF domain; Region: GAF; pfam01590 713604011580 GAF domain; Region: GAF_2; pfam13185 713604011581 ANTAR domain; Region: ANTAR; pfam03861 713604011582 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 713604011583 nucleotide binding site [chemical binding]; other site 713604011584 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604011585 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 713604011586 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604011587 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604011588 substrate binding pocket [chemical binding]; other site 713604011589 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604011590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604011591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604011592 DoxX-like family; Region: DoxX_2; pfam13564 713604011593 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604011594 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 713604011595 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 713604011596 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604011597 iron-sulfur cluster [ion binding]; other site 713604011598 [2Fe-2S] cluster binding site [ion binding]; other site 713604011599 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 713604011600 NAD-dependent deacetylase; Provisional; Region: PRK05333 713604011601 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 713604011602 NAD+ binding site [chemical binding]; other site 713604011603 substrate binding site [chemical binding]; other site 713604011604 Zn binding site [ion binding]; other site 713604011605 TIGR03086 family protein; Region: TIGR03086 713604011606 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 713604011607 heme-binding site [chemical binding]; other site 713604011608 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 713604011609 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 713604011610 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604011611 non-specific DNA binding site [nucleotide binding]; other site 713604011612 salt bridge; other site 713604011613 sequence-specific DNA binding site [nucleotide binding]; other site 713604011614 Cupin domain; Region: Cupin_2; pfam07883 713604011615 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 713604011616 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604011617 Coenzyme A binding pocket [chemical binding]; other site 713604011618 Cupin domain; Region: Cupin_2; pfam07883 713604011619 elongation factor Tu; Reviewed; Region: PRK12736 713604011620 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 713604011621 G1 box; other site 713604011622 GEF interaction site [polypeptide binding]; other site 713604011623 GTP/Mg2+ binding site [chemical binding]; other site 713604011624 Switch I region; other site 713604011625 G2 box; other site 713604011626 G3 box; other site 713604011627 Switch II region; other site 713604011628 G4 box; other site 713604011629 G5 box; other site 713604011630 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 713604011631 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 713604011632 Antibiotic Binding Site [chemical binding]; other site 713604011633 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 713604011634 Right handed beta helix region; Region: Beta_helix; pfam13229 713604011635 acetaldehyde dehydrogenase; Validated; Region: PRK08300 713604011636 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 713604011637 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 713604011638 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 713604011639 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 713604011640 active site 713604011641 catalytic residues [active] 713604011642 metal binding site [ion binding]; metal-binding site 713604011643 DmpG-like communication domain; Region: DmpG_comm; pfam07836 713604011644 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604011645 hypothetical protein; Provisional; Region: PRK06834 713604011646 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604011647 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604011648 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604011649 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 713604011650 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 713604011651 Amidase; Region: Amidase; cl11426 713604011652 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604011653 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604011654 LysE type translocator; Region: LysE; cl00565 713604011655 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 713604011656 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 713604011657 DNA binding site [nucleotide binding] 713604011658 active site 713604011659 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 713604011660 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 713604011661 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 713604011662 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 713604011663 DNA binding site [nucleotide binding] 713604011664 active site 713604011665 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604011666 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604011667 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604011668 DNA binding residues [nucleotide binding] 713604011669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604011670 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 713604011671 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604011672 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 713604011673 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604011674 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604011675 putative DNA binding site [nucleotide binding]; other site 713604011676 putative Zn2+ binding site [ion binding]; other site 713604011677 AsnC family; Region: AsnC_trans_reg; pfam01037 713604011678 hypothetical protein; Provisional; Region: PRK06541 713604011679 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604011680 inhibitor-cofactor binding pocket; inhibition site 713604011681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604011682 catalytic residue [active] 713604011683 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604011684 Cytochrome P450; Region: p450; cl12078 713604011685 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604011686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604011687 DNA binding residues [nucleotide binding] 713604011688 dimerization interface [polypeptide binding]; other site 713604011689 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604011690 active site 713604011691 catalytic triad [active] 713604011692 calcium binding site [ion binding]; other site 713604011693 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604011694 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604011695 active site 713604011696 ATP binding site [chemical binding]; other site 713604011697 substrate binding site [chemical binding]; other site 713604011698 activation loop (A-loop); other site 713604011699 CBD_II domain; Region: CBD_II; smart00637 713604011700 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 713604011701 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604011702 active site 713604011703 heat shock protein 90; Provisional; Region: PRK05218 713604011704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604011705 ATP binding site [chemical binding]; other site 713604011706 Mg2+ binding site [ion binding]; other site 713604011707 G-X-G motif; other site 713604011708 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 713604011709 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 713604011710 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 713604011711 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 713604011712 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 713604011713 CopC domain; Region: CopC; pfam04234 713604011714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 713604011715 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604011716 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604011717 DNA binding residues [nucleotide binding] 713604011718 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604011719 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604011720 active site 713604011721 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 713604011722 oxidoreductase; Provisional; Region: PRK12743 713604011723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011724 NAD(P) binding site [chemical binding]; other site 713604011725 active site 713604011726 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 713604011727 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 713604011728 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 713604011729 putative active site [active] 713604011730 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604011731 active site 713604011732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604011733 active site 713604011734 motif I; other site 713604011735 motif II; other site 713604011736 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 713604011737 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604011738 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604011739 NAD(P) binding site [chemical binding]; other site 713604011740 catalytic residues [active] 713604011741 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 713604011742 translation initiation factor IF-2 subunit beta; Provisional; Region: PRK12336 713604011743 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604011744 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 713604011745 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604011746 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 713604011747 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 713604011748 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 713604011749 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 713604011750 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 713604011751 putative active site [active] 713604011752 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604011753 classical (c) SDRs; Region: SDR_c; cd05233 713604011754 NAD(P) binding site [chemical binding]; other site 713604011755 active site 713604011756 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604011757 substrate binding site [chemical binding]; other site 713604011758 ATP binding site [chemical binding]; other site 713604011759 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604011760 active site 713604011761 HIGH motif; other site 713604011762 nucleotide binding site [chemical binding]; other site 713604011763 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 713604011764 dimer interface [polypeptide binding]; other site 713604011765 active site 713604011766 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 713604011767 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 713604011768 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604011769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011770 NAD(P) binding site [chemical binding]; other site 713604011771 active site 713604011772 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 713604011773 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604011774 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604011775 active site 713604011776 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604011777 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604011778 active site 713604011779 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 713604011780 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 713604011781 putative ADP-binding pocket [chemical binding]; other site 713604011782 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604011783 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604011784 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 713604011785 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 713604011786 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 713604011787 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604011788 NAD binding site [chemical binding]; other site 713604011789 catalytic Zn binding site [ion binding]; other site 713604011790 structural Zn binding site [ion binding]; other site 713604011791 Predicted acyl esterases [General function prediction only]; Region: COG2936 713604011792 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604011793 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604011794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011795 NAD(P) binding site [chemical binding]; other site 713604011796 active site 713604011797 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 713604011798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604011799 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604011800 hydrophobic ligand binding site; other site 713604011801 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 713604011802 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604011803 active site 713604011804 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604011805 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 713604011806 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 713604011807 active site 713604011808 DNA binding site [nucleotide binding] 713604011809 Int/Topo IB signature motif; other site 713604011810 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 713604011811 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 713604011812 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 713604011813 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 713604011814 [2Fe-2S] cluster binding site [ion binding]; other site 713604011815 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604011816 putative methyltransferase; Provisional; Region: PRK14967 713604011817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604011818 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 713604011819 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604011820 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 713604011821 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604011822 anti sigma factor interaction site; other site 713604011823 regulatory phosphorylation site [posttranslational modification]; other site 713604011824 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604011825 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 713604011826 Hemerythrin-like domain; Region: Hr-like; cd12108 713604011827 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 713604011828 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604011829 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604011830 catalytic residue [active] 713604011831 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 713604011832 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 713604011833 amidohydrolase; Region: amidohydrolases; TIGR01891 713604011834 metal binding site [ion binding]; metal-binding site 713604011835 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 713604011836 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 713604011837 substrate binding pocket [chemical binding]; other site 713604011838 active site 713604011839 iron coordination sites [ion binding]; other site 713604011840 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 713604011841 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 713604011842 active site 713604011843 non-prolyl cis peptide bond; other site 713604011844 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604011845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604011846 putative PBP binding loops; other site 713604011847 dimer interface [polypeptide binding]; other site 713604011848 ABC-ATPase subunit interface; other site 713604011849 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604011850 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604011851 Walker A/P-loop; other site 713604011852 ATP binding site [chemical binding]; other site 713604011853 Q-loop/lid; other site 713604011854 ABC transporter signature motif; other site 713604011855 Walker B; other site 713604011856 D-loop; other site 713604011857 H-loop/switch region; other site 713604011858 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 713604011859 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 713604011860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604011861 membrane-bound complex binding site; other site 713604011862 hinge residues; other site 713604011863 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604011864 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604011865 HTH domain; Region: HTH_11; pfam08279 713604011866 WYL domain; Region: WYL; pfam13280 713604011867 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604011868 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604011869 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604011870 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604011871 Predicted ATPase [General function prediction only]; Region: COG3903 713604011872 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604011873 hypothetical protein; Validated; Region: PRK05868 713604011874 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 713604011875 nucleotide binding site/active site [active] 713604011876 HIT family signature motif; other site 713604011877 catalytic residue [active] 713604011878 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604011879 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 713604011880 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 713604011881 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604011882 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604011883 MarR family; Region: MarR; pfam01047 713604011884 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 713604011885 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 713604011886 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 713604011887 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 713604011888 dinuclear metal binding motif [ion binding]; other site 713604011889 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 713604011890 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604011891 catalytic loop [active] 713604011892 iron binding site [ion binding]; other site 713604011893 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 713604011894 FAD binding pocket [chemical binding]; other site 713604011895 conserved FAD binding motif [chemical binding]; other site 713604011896 phosphate binding motif [ion binding]; other site 713604011897 beta-alpha-beta structure motif; other site 713604011898 NAD binding pocket [chemical binding]; other site 713604011899 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 713604011900 dimerization interface [polypeptide binding]; other site 713604011901 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 713604011902 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 713604011903 active site 713604011904 Domain of unknown function DUF59; Region: DUF59; pfam01883 713604011905 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 713604011906 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 713604011907 NAD binding site [chemical binding]; other site 713604011908 substrate binding site [chemical binding]; other site 713604011909 catalytic Zn binding site [ion binding]; other site 713604011910 structural Zn binding site [ion binding]; other site 713604011911 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 713604011912 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 713604011913 ring oligomerisation interface [polypeptide binding]; other site 713604011914 ATP/Mg binding site [chemical binding]; other site 713604011915 stacking interactions; other site 713604011916 hinge regions; other site 713604011917 TIR domain; Region: TIR_2; pfam13676 713604011918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604011919 non-specific DNA binding site [nucleotide binding]; other site 713604011920 salt bridge; other site 713604011921 sequence-specific DNA binding site [nucleotide binding]; other site 713604011922 AAA ATPase domain; Region: AAA_16; pfam13191 713604011923 NB-ARC domain; Region: NB-ARC; pfam00931 713604011924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604011925 binding surface 713604011926 TPR motif; other site 713604011927 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604011928 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604011929 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604011930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604011931 Coenzyme A binding pocket [chemical binding]; other site 713604011932 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604011933 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604011934 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604011935 classical (c) SDRs; Region: SDR_c; cd05233 713604011936 NAD(P) binding site [chemical binding]; other site 713604011937 active site 713604011938 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 713604011939 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604011940 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 713604011941 putative dimer interface [polypeptide binding]; other site 713604011942 N-terminal domain interface [polypeptide binding]; other site 713604011943 putative substrate binding pocket (H-site) [chemical binding]; other site 713604011944 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604011945 MarR family; Region: MarR_2; pfam12802 713604011946 Uncharacterized conserved protein [Function unknown]; Region: COG2353 713604011947 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604011948 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604011949 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 713604011950 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 713604011951 alpha-glucosidase; Provisional; Region: PRK10426 713604011952 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 713604011953 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 713604011954 putative active site [active] 713604011955 putative catalytic site [active] 713604011956 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604011957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604011958 dimer interface [polypeptide binding]; other site 713604011959 conserved gate region; other site 713604011960 putative PBP binding loops; other site 713604011961 ABC-ATPase subunit interface; other site 713604011962 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604011963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604011964 putative PBP binding loops; other site 713604011965 dimer interface [polypeptide binding]; other site 713604011966 ABC-ATPase subunit interface; other site 713604011967 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604011968 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604011969 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604011970 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604011971 DNA binding site [nucleotide binding] 713604011972 domain linker motif; other site 713604011973 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604011974 dimerization interface [polypeptide binding]; other site 713604011975 ligand binding site [chemical binding]; other site 713604011976 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604011977 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604011978 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 713604011979 ligand binding site [chemical binding]; other site 713604011980 metal binding site [ion binding]; metal-binding site 713604011981 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604011982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604011983 S-adenosylmethionine binding site [chemical binding]; other site 713604011984 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604011985 Cytochrome P450; Region: p450; cl12078 713604011986 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604011987 PAS domain; Region: PAS_9; pfam13426 713604011988 putative active site [active] 713604011989 heme pocket [chemical binding]; other site 713604011990 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604011991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604011992 metal binding site [ion binding]; metal-binding site 713604011993 active site 713604011994 I-site; other site 713604011995 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604011996 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 713604011997 putative FMN binding site [chemical binding]; other site 713604011998 putative dimer interface [polypeptide binding]; other site 713604011999 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 713604012000 4Fe-4S binding domain; Region: Fer4; pfam00037 713604012001 Cysteine-rich domain; Region: CCG; pfam02754 713604012002 Cysteine-rich domain; Region: CCG; pfam02754 713604012003 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 713604012004 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 713604012005 phosphopeptide binding site; other site 713604012006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012007 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604012008 putative substrate translocation pore; other site 713604012009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604012010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604012011 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 713604012012 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 713604012013 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 713604012014 shikimate binding site; other site 713604012015 NAD(P) binding site [chemical binding]; other site 713604012016 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604012017 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 713604012018 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604012019 active site 713604012020 metal binding site [ion binding]; metal-binding site 713604012021 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604012022 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604012023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012024 dimer interface [polypeptide binding]; other site 713604012025 conserved gate region; other site 713604012026 putative PBP binding loops; other site 713604012027 ABC-ATPase subunit interface; other site 713604012028 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604012029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012030 dimer interface [polypeptide binding]; other site 713604012031 conserved gate region; other site 713604012032 putative PBP binding loops; other site 713604012033 ABC-ATPase subunit interface; other site 713604012034 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604012035 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 713604012036 AAA ATPase domain; Region: AAA_16; pfam13191 713604012037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604012038 binding surface 713604012039 TPR repeat; Region: TPR_11; pfam13414 713604012040 TPR motif; other site 713604012041 TPR repeat; Region: TPR_11; pfam13414 713604012042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604012043 TPR motif; other site 713604012044 binding surface 713604012045 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 713604012046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604012047 binding surface 713604012048 TPR motif; other site 713604012049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604012050 binding surface 713604012051 TPR motif; other site 713604012052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604012053 binding surface 713604012054 TPR motif; other site 713604012055 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 713604012056 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 713604012057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604012059 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 713604012060 YcaO-like family; Region: YcaO; pfam02624 713604012061 Protein of unknown function (DUF419); Region: DUF419; cl15265 713604012062 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604012063 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604012064 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 713604012065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604012066 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604012067 DNA binding residues [nucleotide binding] 713604012068 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604012069 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604012070 Histidine kinase; Region: HisKA_3; pfam07730 713604012071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604012072 Mg2+ binding site [ion binding]; other site 713604012073 G-X-G motif; other site 713604012074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604012075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604012076 active site 713604012077 phosphorylation site [posttranslational modification] 713604012078 intermolecular recognition site; other site 713604012079 dimerization interface [polypeptide binding]; other site 713604012080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604012081 DNA binding residues [nucleotide binding] 713604012082 dimerization interface [polypeptide binding]; other site 713604012083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604012084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604012085 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604012086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604012087 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 713604012088 GTP cyclohydrolase I; Provisional; Region: PLN03044 713604012089 active site 713604012090 Predicted transcriptional regulator [Transcription]; Region: COG2345 713604012091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604012092 putative DNA binding site [nucleotide binding]; other site 713604012093 putative Zn2+ binding site [ion binding]; other site 713604012094 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012095 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012096 DNA binding site [nucleotide binding] 713604012097 domain linker motif; other site 713604012098 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 713604012099 ligand binding site [chemical binding]; other site 713604012100 dimerization interface (open form) [polypeptide binding]; other site 713604012101 dimerization interface (closed form) [polypeptide binding]; other site 713604012102 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 713604012103 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 713604012104 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 713604012105 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 713604012106 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 713604012107 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 713604012108 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604012109 classical (c) SDRs; Region: SDR_c; cd05233 713604012110 NAD(P) binding site [chemical binding]; other site 713604012111 active site 713604012112 Cellulose binding domain; Region: CBM_2; pfam00553 713604012113 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 713604012114 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 713604012115 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 713604012116 putative catalytic site [active] 713604012117 putative metal binding site [ion binding]; other site 713604012118 putative phosphate binding site [ion binding]; other site 713604012119 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012120 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012121 DNA binding site [nucleotide binding] 713604012122 domain linker motif; other site 713604012123 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 713604012124 ligand binding site [chemical binding]; other site 713604012125 dimerization interface (open form) [polypeptide binding]; other site 713604012126 dimerization interface (closed form) [polypeptide binding]; other site 713604012127 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 713604012128 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604012129 putative ligand binding site [chemical binding]; other site 713604012130 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 713604012131 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604012132 Walker A/P-loop; other site 713604012133 ATP binding site [chemical binding]; other site 713604012134 Q-loop/lid; other site 713604012135 ABC transporter signature motif; other site 713604012136 Walker B; other site 713604012137 D-loop; other site 713604012138 H-loop/switch region; other site 713604012139 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604012140 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012141 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012142 TM-ABC transporter signature motif; other site 713604012143 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012144 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012145 TM-ABC transporter signature motif; other site 713604012146 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604012147 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604012148 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604012149 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 713604012150 ribulokinase; Provisional; Region: PRK04123 713604012151 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604012152 nucleotide binding site [chemical binding]; other site 713604012153 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 713604012154 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 713604012155 intersubunit interface [polypeptide binding]; other site 713604012156 active site 713604012157 Zn2+ binding site [ion binding]; other site 713604012158 L-arabinose isomerase; Provisional; Region: PRK02929 713604012159 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 713604012160 hexamer (dimer of trimers) interface [polypeptide binding]; other site 713604012161 trimer interface [polypeptide binding]; other site 713604012162 substrate binding site [chemical binding]; other site 713604012163 Mn binding site [ion binding]; other site 713604012164 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 713604012165 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 713604012166 putative ligand binding site [chemical binding]; other site 713604012167 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 713604012168 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604012169 Walker A/P-loop; other site 713604012170 ATP binding site [chemical binding]; other site 713604012171 Q-loop/lid; other site 713604012172 ABC transporter signature motif; other site 713604012173 Walker B; other site 713604012174 D-loop; other site 713604012175 H-loop/switch region; other site 713604012176 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604012177 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012178 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012179 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012180 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012181 TM-ABC transporter signature motif; other site 713604012182 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604012183 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604012184 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012185 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 713604012186 ligand binding site [chemical binding]; other site 713604012187 dimerization interface (open form) [polypeptide binding]; other site 713604012188 dimerization interface (closed form) [polypeptide binding]; other site 713604012189 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604012190 Cytochrome P450; Region: p450; cl12078 713604012191 glycerol kinase; Provisional; Region: glpK; PRK00047 713604012192 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 713604012193 N- and C-terminal domain interface [polypeptide binding]; other site 713604012194 active site 713604012195 MgATP binding site [chemical binding]; other site 713604012196 catalytic site [active] 713604012197 metal binding site [ion binding]; metal-binding site 713604012198 putative homotetramer interface [polypeptide binding]; other site 713604012199 glycerol binding site [chemical binding]; other site 713604012200 homodimer interface [polypeptide binding]; other site 713604012201 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 713604012202 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604012203 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604012204 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604012205 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 713604012206 amphipathic channel; other site 713604012207 Asn-Pro-Ala signature motifs; other site 713604012208 glycerol kinase; Provisional; Region: glpK; PRK00047 713604012209 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 713604012210 N- and C-terminal domain interface [polypeptide binding]; other site 713604012211 active site 713604012212 MgATP binding site [chemical binding]; other site 713604012213 catalytic site [active] 713604012214 metal binding site [ion binding]; metal-binding site 713604012215 putative homotetramer interface [polypeptide binding]; other site 713604012216 glycerol binding site [chemical binding]; other site 713604012217 homodimer interface [polypeptide binding]; other site 713604012218 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 713604012219 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604012220 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604012221 Phosphotransferase enzyme family; Region: APH; pfam01636 713604012222 active site 713604012223 substrate binding site [chemical binding]; other site 713604012224 ATP binding site [chemical binding]; other site 713604012225 argininosuccinate synthase; Validated; Region: PRK05370 713604012226 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 713604012227 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604012228 putative NAD(P) binding site [chemical binding]; other site 713604012229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604012230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604012231 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604012232 DNA binding site [nucleotide binding] 713604012233 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604012234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604012235 AAA domain; Region: AAA_22; pfam13401 713604012236 Walker A motif; other site 713604012237 ATP binding site [chemical binding]; other site 713604012238 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604012239 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604012240 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604012241 binding surface 713604012242 TPR motif; other site 713604012243 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 713604012244 putative active site [active] 713604012245 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604012246 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604012247 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604012248 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604012249 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604012250 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604012251 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 713604012252 FAD binding domain; Region: FAD_binding_4; pfam01565 713604012253 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 713604012254 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012255 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012256 DNA binding site [nucleotide binding] 713604012257 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604012258 ligand binding site [chemical binding]; other site 713604012259 dimerization interface [polypeptide binding]; other site 713604012260 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604012261 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604012262 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604012263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604012264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604012265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012266 dimer interface [polypeptide binding]; other site 713604012267 putative PBP binding loops; other site 713604012268 ABC-ATPase subunit interface; other site 713604012269 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604012270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012271 dimer interface [polypeptide binding]; other site 713604012272 conserved gate region; other site 713604012273 putative PBP binding loops; other site 713604012274 ABC-ATPase subunit interface; other site 713604012275 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604012276 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604012277 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604012278 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604012279 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604012280 Methane oxygenase PmoA; Region: PmoA; pfam14100 713604012281 Amb_all domain; Region: Amb_all; smart00656 713604012282 Pectate lyase; Region: Pectate_lyase; pfam03211 713604012283 Pectinesterase; Region: Pectinesterase; pfam01095 713604012284 putative pectinesterase; Region: PLN02432; cl01911 713604012285 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 713604012286 substrate binding site [chemical binding]; other site 713604012287 active site 713604012288 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 713604012289 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 713604012290 Beta-galactosidase, domain 2; Region: BetaGal_dom2; pfam10435 713604012291 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 713604012292 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 713604012293 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 713604012294 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604012295 anti sigma factor interaction site; other site 713604012296 regulatory phosphorylation site [posttranslational modification]; other site 713604012297 DNA binding site [nucleotide binding] 713604012298 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604012299 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604012300 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604012301 Ligand Binding Site [chemical binding]; other site 713604012302 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604012303 Ligand Binding Site [chemical binding]; other site 713604012304 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 713604012305 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 713604012306 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 713604012307 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 713604012308 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 713604012309 Type II/IV secretion system protein; Region: T2SE; pfam00437 713604012310 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 713604012311 Walker A motif; other site 713604012312 ATP binding site [chemical binding]; other site 713604012313 Walker B motif; other site 713604012314 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 713604012315 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604012316 Walker A motif; other site 713604012317 ATP binding site [chemical binding]; other site 713604012318 Walker B motif; other site 713604012319 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 713604012320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604012321 TIGR01777 family protein; Region: yfcH 713604012322 NAD(P) binding site [chemical binding]; other site 713604012323 active site 713604012324 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604012325 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604012326 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604012327 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 713604012328 NAD(P) binding site [chemical binding]; other site 713604012329 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 713604012330 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 713604012331 ligand binding site; other site 713604012332 oligomer interface; other site 713604012333 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 713604012334 dimer interface [polypeptide binding]; other site 713604012335 N-terminal domain interface [polypeptide binding]; other site 713604012336 sulfate 1 binding site; other site 713604012337 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 713604012338 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604012339 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604012340 Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; pfam02752 713604012341 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604012342 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604012343 anti sigma factor interaction site; other site 713604012344 regulatory phosphorylation site [posttranslational modification]; other site 713604012345 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 713604012346 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604012347 DNA binding residues [nucleotide binding] 713604012348 B12 binding domain; Region: B12-binding_2; pfam02607 713604012349 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 713604012350 putative hydrophobic ligand binding site [chemical binding]; other site 713604012351 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604012352 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604012353 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604012354 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604012355 sugar binding site [chemical binding]; other site 713604012356 TROVE domain; Region: TROVE; pfam05731 713604012357 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 713604012358 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604012359 elongation factor G; Reviewed; Region: PRK13351 713604012360 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604012361 G1 box; other site 713604012362 GTP/Mg2+ binding site [chemical binding]; other site 713604012363 G2 box; other site 713604012364 Switch I region; other site 713604012365 G3 box; other site 713604012366 Switch II region; other site 713604012367 G4 box; other site 713604012368 G5 box; other site 713604012369 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 713604012370 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 713604012371 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 713604012372 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604012373 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604012374 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604012375 catalytic residue [active] 713604012376 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 713604012377 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 713604012378 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604012379 hydrophobic ligand binding site; other site 713604012380 hypothetical protein; Provisional; Region: PRK06185 713604012381 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604012382 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604012383 MarR family; Region: MarR; pfam01047 713604012384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012385 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604012386 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604012387 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 713604012388 active site 713604012389 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604012390 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604012391 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604012392 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 713604012393 acyl-CoA synthetase; Validated; Region: PRK05850 713604012394 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604012395 acyl-activating enzyme (AAE) consensus motif; other site 713604012396 active site 713604012397 Predicted esterase [General function prediction only]; Region: COG0627 713604012398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604012399 NAD(P) binding site [chemical binding]; other site 713604012400 active site 713604012401 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604012402 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604012403 active site 713604012404 TDP-binding site; other site 713604012405 acceptor substrate-binding pocket; other site 713604012406 homodimer interface [polypeptide binding]; other site 713604012407 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 713604012408 Uncharacterized conserved protein [Function unknown]; Region: COG1434 713604012409 putative active site [active] 713604012410 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 713604012411 ATP-NAD kinase; Region: NAD_kinase; pfam01513 713604012412 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 713604012413 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604012414 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604012415 short chain dehydrogenase; Provisional; Region: PRK05650 713604012416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604012417 NAD(P) binding site [chemical binding]; other site 713604012418 active site 713604012419 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604012420 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604012421 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604012422 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604012423 Cytochrome P450; Region: p450; cl12078 713604012424 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604012425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604012426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604012427 NB-ARC domain; Region: NB-ARC; pfam00931 713604012428 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 713604012429 regulatory protein interface [polypeptide binding]; other site 713604012430 active site 713604012431 regulatory phosphorylation site [posttranslational modification]; other site 713604012432 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 713604012433 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 713604012434 active site 713604012435 P-loop; other site 713604012436 phosphorylation site [posttranslational modification] 713604012437 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 713604012438 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 713604012439 active site 713604012440 phosphorylation site [posttranslational modification] 713604012441 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 713604012442 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 713604012443 putative substrate binding site [chemical binding]; other site 713604012444 putative ATP binding site [chemical binding]; other site 713604012445 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604012446 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604012447 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 713604012448 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 713604012449 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 713604012450 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 713604012451 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 713604012452 ATP binding site [chemical binding]; other site 713604012453 Asp23 family; Region: Asp23; pfam03780 713604012454 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 713604012455 active site 713604012456 catalytic triad [active] 713604012457 oxyanion hole [active] 713604012458 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 713604012459 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604012460 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604012461 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012462 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012463 DNA binding site [nucleotide binding] 713604012464 domain linker motif; other site 713604012465 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604012466 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604012467 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604012468 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 713604012469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012470 dimer interface [polypeptide binding]; other site 713604012471 conserved gate region; other site 713604012472 putative PBP binding loops; other site 713604012473 ABC-ATPase subunit interface; other site 713604012474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604012475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012476 dimer interface [polypeptide binding]; other site 713604012477 conserved gate region; other site 713604012478 putative PBP binding loops; other site 713604012479 ABC-ATPase subunit interface; other site 713604012480 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012481 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012482 DNA binding site [nucleotide binding] 713604012483 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 713604012484 putative ligand binding site [chemical binding]; other site 713604012485 putative dimerization interface [polypeptide binding]; other site 713604012486 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604012487 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 713604012488 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604012489 NodB motif; other site 713604012490 active site 713604012491 catalytic site [active] 713604012492 metal binding site [ion binding]; metal-binding site 713604012493 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604012494 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604012495 Di-iron ligands [ion binding]; other site 713604012496 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604012497 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604012498 DNA-binding site [nucleotide binding]; DNA binding site 713604012499 RNA-binding motif; other site 713604012500 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 713604012501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604012502 S-adenosylmethionine binding site [chemical binding]; other site 713604012503 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604012504 FAD binding domain; Region: FAD_binding_4; pfam01565 713604012505 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604012506 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 713604012507 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 713604012508 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 713604012509 oligomer interface [polypeptide binding]; other site 713604012510 metal binding site [ion binding]; metal-binding site 713604012511 metal binding site [ion binding]; metal-binding site 713604012512 putative Cl binding site [ion binding]; other site 713604012513 aspartate ring; other site 713604012514 basic sphincter; other site 713604012515 hydrophobic gate; other site 713604012516 periplasmic entrance; other site 713604012517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604012518 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 713604012519 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012520 dimerization interface [polypeptide binding]; other site 713604012521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012522 dimerization interface [polypeptide binding]; other site 713604012523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012524 dimerization interface [polypeptide binding]; other site 713604012525 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 713604012526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012527 dimerization interface [polypeptide binding]; other site 713604012528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012529 dimerization interface [polypeptide binding]; other site 713604012530 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012531 dimerization interface [polypeptide binding]; other site 713604012532 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012533 dimerization interface [polypeptide binding]; other site 713604012534 GAF domain; Region: GAF_2; pfam13185 713604012535 GAF domain; Region: GAF; pfam01590 713604012536 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 713604012537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604012538 ATP binding site [chemical binding]; other site 713604012539 Mg2+ binding site [ion binding]; other site 713604012540 G-X-G motif; other site 713604012541 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 713604012542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604012543 active site 713604012544 phosphorylation site [posttranslational modification] 713604012545 intermolecular recognition site; other site 713604012546 dimerization interface [polypeptide binding]; other site 713604012547 ANTAR domain; Region: ANTAR; pfam03861 713604012548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604012549 PAS fold; Region: PAS_3; pfam08447 713604012550 putative active site [active] 713604012551 heme pocket [chemical binding]; other site 713604012552 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604012553 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 713604012554 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 713604012555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604012556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604012557 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 713604012558 putative dimerization interface [polypeptide binding]; other site 713604012559 pyruvate dehydrogenase; Provisional; Region: PRK06546 713604012560 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 713604012561 PYR/PP interface [polypeptide binding]; other site 713604012562 dimer interface [polypeptide binding]; other site 713604012563 tetramer interface [polypeptide binding]; other site 713604012564 TPP binding site [chemical binding]; other site 713604012565 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604012566 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 713604012567 TPP-binding site [chemical binding]; other site 713604012568 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 713604012569 Fructosamine kinase; Region: Fructosamin_kin; cl17579 713604012570 Protein of unknown function (DUF419); Region: DUF419; pfam04237 713604012571 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 713604012572 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 713604012573 Zn binding site [ion binding]; other site 713604012574 Protein of unknown function, DUF488; Region: DUF488; cl01246 713604012575 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604012576 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604012577 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604012578 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012579 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012580 DNA binding site [nucleotide binding] 713604012581 domain linker motif; other site 713604012582 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604012583 dimerization interface [polypeptide binding]; other site 713604012584 ligand binding site [chemical binding]; other site 713604012585 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 713604012586 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604012587 Walker A/P-loop; other site 713604012588 ATP binding site [chemical binding]; other site 713604012589 Q-loop/lid; other site 713604012590 ABC transporter signature motif; other site 713604012591 Walker B; other site 713604012592 D-loop; other site 713604012593 H-loop/switch region; other site 713604012594 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604012595 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012596 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012597 TM-ABC transporter signature motif; other site 713604012598 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012599 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012600 TM-ABC transporter signature motif; other site 713604012601 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 713604012602 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 713604012603 ligand binding site [chemical binding]; other site 713604012604 Domain of unknown function (DUF718); Region: DUF718; pfam05336 713604012605 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 713604012606 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 713604012607 short chain dehydrogenase; Validated; Region: PRK08324 713604012608 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 713604012609 active site 713604012610 Zn2+ binding site [ion binding]; other site 713604012611 intersubunit interface [polypeptide binding]; other site 713604012612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604012613 NAD(P) binding site [chemical binding]; other site 713604012614 active site 713604012615 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 713604012616 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 713604012617 hexamer (dimer of trimers) interface [polypeptide binding]; other site 713604012618 substrate binding site [chemical binding]; other site 713604012619 trimer interface [polypeptide binding]; other site 713604012620 Mn binding site [ion binding]; other site 713604012621 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 713604012622 N- and C-terminal domain interface [polypeptide binding]; other site 713604012623 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 713604012624 active site 713604012625 putative catalytic site [active] 713604012626 metal binding site [ion binding]; metal-binding site 713604012627 ATP binding site [chemical binding]; other site 713604012628 carbohydrate binding site [chemical binding]; other site 713604012629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604012630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604012631 active site 713604012632 phosphorylation site [posttranslational modification] 713604012633 intermolecular recognition site; other site 713604012634 dimerization interface [polypeptide binding]; other site 713604012635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604012636 DNA binding residues [nucleotide binding] 713604012637 dimerization interface [polypeptide binding]; other site 713604012638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604012639 Histidine kinase; Region: HisKA_3; pfam07730 713604012640 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012641 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012642 DNA binding site [nucleotide binding] 713604012643 domain linker motif; other site 713604012644 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 713604012645 putative dimerization interface [polypeptide binding]; other site 713604012646 putative ligand binding site [chemical binding]; other site 713604012647 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604012648 putative metal binding site [ion binding]; other site 713604012649 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604012650 putative metal binding site [ion binding]; other site 713604012651 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 713604012652 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 713604012653 active site 713604012654 catalytic site [active] 713604012655 Domain of unknown function (DUF305); Region: DUF305; cl17794 713604012656 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604012657 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604012658 sugar binding site [chemical binding]; other site 713604012659 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 713604012660 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604012661 active site 713604012662 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604012663 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 713604012664 DNA polymerase IV; Validated; Region: PRK03858 713604012665 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 713604012666 active site 713604012667 DNA binding site [nucleotide binding] 713604012668 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604012669 Leucine carboxyl methyltransferase; Region: LCM; cl01306 713604012670 Lsr2; Region: Lsr2; pfam11774 713604012671 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604012672 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 713604012673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604012674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604012675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604012676 dimerization interface [polypeptide binding]; other site 713604012677 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 713604012678 CoA binding domain; Region: CoA_binding; pfam02629 713604012679 CoA-ligase; Region: Ligase_CoA; pfam00549 713604012680 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 713604012681 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 713604012682 CoA-ligase; Region: Ligase_CoA; pfam00549 713604012683 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604012684 hypothetical protein; Provisional; Region: PRK05858 713604012685 PYR/PP interface [polypeptide binding]; other site 713604012686 dimer interface [polypeptide binding]; other site 713604012687 TPP binding site [chemical binding]; other site 713604012688 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604012689 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 713604012690 TPP-binding site; other site 713604012691 dimer interface [polypeptide binding]; other site 713604012692 formyl-coenzyme A transferase; Provisional; Region: PRK05398 713604012693 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604012694 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 713604012695 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 713604012696 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 713604012697 CoA binding domain; Region: CoA_binding_2; pfam13380 713604012698 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 713604012699 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 713604012700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012701 putative substrate translocation pore; other site 713604012702 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604012703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604012704 DNA-binding site [nucleotide binding]; DNA binding site 713604012705 FCD domain; Region: FCD; pfam07729 713604012706 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 713604012707 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 713604012708 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 713604012709 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 713604012710 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604012711 molybdopterin cofactor binding site; other site 713604012712 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 713604012713 molybdopterin cofactor binding site; other site 713604012714 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 713604012715 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 713604012716 putative dimer interface [polypeptide binding]; other site 713604012717 [2Fe-2S] cluster binding site [ion binding]; other site 713604012718 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 713604012719 SLBB domain; Region: SLBB; pfam10531 713604012720 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 713604012721 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604012722 catalytic loop [active] 713604012723 iron binding site [ion binding]; other site 713604012724 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 713604012725 4Fe-4S binding domain; Region: Fer4; pfam00037 713604012726 Molybdopterin oxidoreductase Fe4S4 domain; Region: Molybdop_Fe4S4; pfam04879 713604012727 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 713604012728 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604012729 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 713604012730 glyoxylate carboligase; Provisional; Region: PRK11269 713604012731 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604012732 PYR/PP interface [polypeptide binding]; other site 713604012733 dimer interface [polypeptide binding]; other site 713604012734 TPP binding site [chemical binding]; other site 713604012735 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604012736 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604012737 TPP-binding site [chemical binding]; other site 713604012738 4-hydroxybenzoyl-CoA reductase, beta subunit; Region: 4hydrxCoA_B; TIGR03195 713604012739 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 713604012740 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604012741 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 713604012742 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604012743 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 713604012744 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604012745 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604012746 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 713604012747 nucleoside/Zn binding site; other site 713604012748 dimer interface [polypeptide binding]; other site 713604012749 catalytic motif [active] 713604012750 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 713604012751 Sulfate transporter family; Region: Sulfate_transp; pfam00916 713604012752 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 713604012753 putative active site pocket [active] 713604012754 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 713604012755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604012756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604012757 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 713604012758 Domain interface; other site 713604012759 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 713604012760 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604012761 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 713604012762 SPFH domain / Band 7 family; Region: Band_7; pfam01145 713604012763 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 713604012764 nudix motif; other site 713604012765 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 713604012766 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604012767 hypothetical protein; Provisional; Region: PRK07588 713604012768 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604012769 putative DNA binding site [nucleotide binding]; other site 713604012770 putative Zn2+ binding site [ion binding]; other site 713604012771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 713604012772 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 713604012773 DNA-binding interface [nucleotide binding]; DNA binding site 713604012774 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604012775 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 713604012776 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604012777 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 713604012778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012780 DNA binding site [nucleotide binding] 713604012781 domain linker motif; other site 713604012782 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604012783 dimerization interface [polypeptide binding]; other site 713604012784 ligand binding site [chemical binding]; other site 713604012785 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 713604012786 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 713604012787 glutaminase; Provisional; Region: PRK00971 713604012788 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 713604012789 AAA domain; Region: AAA_12; pfam13087 713604012790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 713604012791 YheO-like PAS domain; Region: PAS_6; pfam08348 713604012792 HTH domain; Region: HTH_22; pfam13309 713604012793 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 713604012794 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 713604012795 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604012796 catalytic residue [active] 713604012797 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604012798 phosphate binding site [ion binding]; other site 713604012799 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 713604012800 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604012801 phosphate binding site [ion binding]; other site 713604012802 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604012803 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 713604012804 active site 713604012805 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 713604012806 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604012807 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 713604012808 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 713604012809 putative NADP binding site [chemical binding]; other site 713604012810 active site 713604012811 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604012812 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604012813 active site 713604012814 Acyl transferase domain; Region: Acyl_transf_1; cl08282 713604012815 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 713604012816 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 713604012817 Phosphopantetheine attachment site; Region: PP-binding; cl09936 713604012818 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604012819 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604012820 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 713604012821 catalytic site [active] 713604012822 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604012823 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604012824 classical (c) SDRs; Region: SDR_c; cd05233 713604012825 NAD(P) binding site [chemical binding]; other site 713604012826 active site 713604012827 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604012828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012829 putative substrate translocation pore; other site 713604012830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012831 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 713604012832 histidinol-phosphatase; Provisional; Region: PRK05588 713604012833 active site 713604012834 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 713604012835 nucleotide binding site [chemical binding]; other site 713604012836 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 713604012837 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604012838 dimer interface [polypeptide binding]; other site 713604012839 active site 713604012840 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604012841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604012842 dimerization interface [polypeptide binding]; other site 713604012843 putative DNA binding site [nucleotide binding]; other site 713604012844 putative Zn2+ binding site [ion binding]; other site 713604012845 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 713604012846 sugar binding site [chemical binding]; other site 713604012847 CARDB; Region: CARDB; pfam07705 713604012848 CARDB; Region: CARDB; pfam07705 713604012849 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604012850 putative metal binding site [ion binding]; other site 713604012851 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 713604012852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604012853 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604012854 NAD(P) binding site [chemical binding]; other site 713604012855 active site 713604012856 ATP phosphoribosyltransferase; Region: HisG; cl15266 713604012857 DoxX-like family; Region: DoxX_2; pfam13564 713604012858 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604012859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604012860 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604012861 dimerization interface [polypeptide binding]; other site 713604012862 substrate binding pocket [chemical binding]; other site 713604012863 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 713604012864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604012865 motif II; other site 713604012866 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604012867 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604012868 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604012869 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604012870 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012872 DNA binding site [nucleotide binding] 713604012873 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604012874 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 713604012875 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 713604012876 hypothetical protein; Provisional; Region: PRK07906 713604012877 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 713604012878 putative metal binding site [ion binding]; other site 713604012879 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604012880 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604012881 hypothetical protein; Provisional; Region: PRK08317 713604012882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604012883 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604012884 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604012885 DNA binding residues [nucleotide binding] 713604012886 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604012887 putative DNA binding site [nucleotide binding]; other site 713604012888 putative Zn2+ binding site [ion binding]; other site 713604012889 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604012890 hydrophobic ligand binding site; other site 713604012891 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604012892 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604012893 active site 713604012894 catalytic tetrad [active] 713604012895 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604012896 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 713604012897 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 713604012898 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604012899 catalytic core [active] 713604012900 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 713604012901 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 713604012902 active site 713604012903 Zn binding site [ion binding]; other site 713604012904 Clp protease; Region: CLP_protease; pfam00574 713604012905 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 713604012906 oligomer interface [polypeptide binding]; other site 713604012907 active site residues [active] 713604012908 malate dehydrogenase; Provisional; Region: PRK05442 713604012909 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 713604012910 NAD(P) binding site [chemical binding]; other site 713604012911 dimer interface [polypeptide binding]; other site 713604012912 malate binding site [chemical binding]; other site 713604012913 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604012914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604012915 putative DNA binding site [nucleotide binding]; other site 713604012916 putative Zn2+ binding site [ion binding]; other site 713604012917 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604012918 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604012919 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 713604012920 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 713604012921 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604012922 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604012923 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604012924 sugar binding site [chemical binding]; other site 713604012925 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604012926 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604012927 Tannase and feruloyl esterase; Region: Tannase; pfam07519 713604012928 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604012929 Cupin domain; Region: Cupin_2; cl17218 713604012930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604012931 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604012932 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604012933 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604012934 NAD(P) binding site [chemical binding]; other site 713604012935 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 713604012936 hypothetical protein; Provisional; Region: PRK07906 713604012937 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 713604012938 putative metal binding site [ion binding]; other site 713604012939 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 713604012940 SxDxEG motif; other site 713604012941 active site 713604012942 metal binding site [ion binding]; metal-binding site 713604012943 homopentamer interface [polypeptide binding]; other site 713604012944 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 713604012945 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 713604012946 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604012947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012948 putative PBP binding loops; other site 713604012949 dimer interface [polypeptide binding]; other site 713604012950 ABC-ATPase subunit interface; other site 713604012951 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604012952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012953 dimer interface [polypeptide binding]; other site 713604012954 conserved gate region; other site 713604012955 putative PBP binding loops; other site 713604012956 ABC-ATPase subunit interface; other site 713604012957 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 713604012958 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604012959 Walker A/P-loop; other site 713604012960 ATP binding site [chemical binding]; other site 713604012961 Q-loop/lid; other site 713604012962 ABC transporter signature motif; other site 713604012963 Walker B; other site 713604012964 D-loop; other site 713604012965 H-loop/switch region; other site 713604012966 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604012967 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604012968 Walker A/P-loop; other site 713604012969 ATP binding site [chemical binding]; other site 713604012970 Q-loop/lid; other site 713604012971 ABC transporter signature motif; other site 713604012972 Walker B; other site 713604012973 D-loop; other site 713604012974 H-loop/switch region; other site 713604012975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604012976 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 713604012977 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 713604012978 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 713604012979 dimer interface [polypeptide binding]; other site 713604012980 catalytic triad [active] 713604012981 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 713604012982 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604012983 conserved hypothetical protein; Region: TIGR03847 713604012984 conserved hypothetical protein; Region: TIGR03843 713604012985 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 713604012986 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 713604012987 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 713604012988 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 713604012989 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 713604012990 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 713604012991 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 713604012992 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604012993 active site 713604012994 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 713604012995 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 713604012996 Mechanosensitive ion channel; Region: MS_channel; pfam00924 713604012997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012998 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604012999 putative substrate translocation pore; other site 713604013000 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604013001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013002 hypothetical protein; Provisional; Region: PRK06834 713604013003 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604013004 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604013005 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604013006 active site 713604013007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013008 dimerization interface [polypeptide binding]; other site 713604013009 putative DNA binding site [nucleotide binding]; other site 713604013010 putative Zn2+ binding site [ion binding]; other site 713604013011 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 713604013012 putative hydrophobic ligand binding site [chemical binding]; other site 713604013013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013015 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 713604013016 active site 713604013017 catalytic triad [active] 713604013018 oxyanion hole [active] 713604013019 RibD C-terminal domain; Region: RibD_C; cl17279 713604013020 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604013021 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 713604013022 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604013023 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604013024 active site 713604013025 DNA binding site [nucleotide binding] 713604013026 Int/Topo IB signature motif; other site 713604013027 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604013028 YCII-related domain; Region: YCII; cl00999 713604013029 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604013030 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604013031 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013032 dimerization interface [polypeptide binding]; other site 713604013033 putative DNA binding site [nucleotide binding]; other site 713604013034 putative Zn2+ binding site [ion binding]; other site 713604013035 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 713604013036 putative hydrophobic ligand binding site [chemical binding]; other site 713604013037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013038 Cupin; Region: Cupin_6; pfam12852 713604013039 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604013040 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604013041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604013042 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604013043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604013044 NAD(P) binding site [chemical binding]; other site 713604013045 active site 713604013046 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 713604013047 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 713604013048 YCII-related domain; Region: YCII; cl00999 713604013049 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604013050 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604013051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604013052 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604013053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013055 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604013056 Cytochrome P450; Region: p450; cl12078 713604013057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013059 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604013060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013061 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604013062 Walker A/P-loop; other site 713604013063 ATP binding site [chemical binding]; other site 713604013064 Q-loop/lid; other site 713604013065 ABC transporter signature motif; other site 713604013066 Walker B; other site 713604013067 D-loop; other site 713604013068 H-loop/switch region; other site 713604013069 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604013070 SNF2 Helicase protein; Region: DUF3670; pfam12419 713604013071 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 713604013072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604013073 ATP binding site [chemical binding]; other site 713604013074 putative Mg++ binding site [ion binding]; other site 713604013075 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 713604013076 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604013077 nucleotide binding region [chemical binding]; other site 713604013078 ATP-binding site [chemical binding]; other site 713604013079 Uncharacterized conserved protein [Function unknown]; Region: COG4279 713604013080 SWIM zinc finger; Region: SWIM; pfam04434 713604013081 hypothetical protein; Provisional; Region: PRK07236 713604013082 hypothetical protein; Validated; Region: PRK05868 713604013083 hypothetical protein; Provisional; Region: PRK07236 713604013084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013086 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604013087 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 713604013088 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604013089 active site 713604013090 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 713604013091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013092 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604013093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604013094 salt bridge; other site 713604013095 non-specific DNA binding site [nucleotide binding]; other site 713604013096 sequence-specific DNA binding site [nucleotide binding]; other site 713604013097 Cupin domain; Region: Cupin_2; cl17218 713604013098 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 713604013099 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604013100 hydrophobic ligand binding site; other site 713604013101 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013102 dimerization interface [polypeptide binding]; other site 713604013103 putative DNA binding site [nucleotide binding]; other site 713604013104 putative Zn2+ binding site [ion binding]; other site 713604013105 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 713604013106 putative hydrophobic ligand binding site [chemical binding]; other site 713604013107 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604013108 active site 713604013109 DNA binding site [nucleotide binding] 713604013110 Int/Topo IB signature motif; other site 713604013111 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 713604013112 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 713604013113 putative active site [active] 713604013114 catalytic site [active] 713604013115 putative metal binding site [ion binding]; other site 713604013116 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 713604013117 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604013118 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 713604013119 thymidine kinase; Provisional; Region: PRK04296 713604013120 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604013121 ATP binding site [chemical binding]; other site 713604013122 Walker A motif; other site 713604013123 Walker B motif; other site 713604013124 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 713604013125 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 713604013126 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 713604013127 dimer interface [polypeptide binding]; other site 713604013128 ADP-ribose binding site [chemical binding]; other site 713604013129 active site 713604013130 nudix motif; other site 713604013131 metal binding site [ion binding]; metal-binding site 713604013132 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 713604013133 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604013134 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604013135 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 713604013136 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 713604013137 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 713604013138 Ligand binding site; other site 713604013139 Putative Catalytic site; other site 713604013140 DXD motif; other site 713604013141 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 713604013142 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 713604013143 putative active site [active] 713604013144 catalytic triad [active] 713604013145 putative dimer interface [polypeptide binding]; other site 713604013146 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 713604013147 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604013148 active site 713604013149 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 713604013150 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 713604013151 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604013152 conserved cys residue [active] 713604013153 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604013154 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604013155 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604013156 DNA binding site [nucleotide binding] 713604013157 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604013158 AAA ATPase domain; Region: AAA_16; pfam13191 713604013159 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604013160 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604013161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604013162 TPR motif; other site 713604013163 binding surface 713604013164 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604013165 Homeodomain-like domain; Region: HTH_23; pfam13384 713604013166 Winged helix-turn helix; Region: HTH_29; pfam13551 713604013167 Homeodomain-like domain; Region: HTH_32; pfam13565 713604013168 DDE superfamily endonuclease; Region: DDE_3; pfam13358 713604013169 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 713604013170 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 713604013171 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 713604013172 active site 713604013173 zinc binding site [ion binding]; other site 713604013174 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604013175 DNA binding site [nucleotide binding] 713604013176 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604013177 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 713604013178 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 713604013179 active site 713604013180 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604013181 active site 713604013182 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 713604013183 B12 binding site [chemical binding]; other site 713604013184 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 713604013185 substrate binding site [chemical binding]; other site 713604013186 B12 cofactor binding site [chemical binding]; other site 713604013187 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 713604013188 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 713604013189 asparagine synthetase A; Reviewed; Region: PRK06462 713604013190 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604013191 motif 1; other site 713604013192 dimer interface [polypeptide binding]; other site 713604013193 active site 713604013194 motif 2; other site 713604013195 motif 3; other site 713604013196 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604013197 phosphate binding site [ion binding]; other site 713604013198 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 713604013199 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013200 acyl-activating enzyme (AAE) consensus motif; other site 713604013201 AMP binding site [chemical binding]; other site 713604013202 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 713604013203 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 713604013204 homodimer interface [polypeptide binding]; other site 713604013205 substrate-cofactor binding pocket; other site 713604013206 catalytic residue [active] 713604013207 FkbH-like domain; Region: FkbH; TIGR01686 713604013208 Acid Phosphatase; Region: Acid_PPase; cl17256 713604013209 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604013210 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604013211 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604013212 active site 713604013213 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604013214 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 713604013215 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604013216 catalytic residue [active] 713604013217 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 713604013218 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 713604013219 active sites [active] 713604013220 tetramer interface [polypeptide binding]; other site 713604013221 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 713604013222 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604013223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604013224 dimer interface [polypeptide binding]; other site 713604013225 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604013226 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 713604013227 acyl carrier protein; Provisional; Region: PRK07081 713604013228 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 713604013229 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604013230 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604013231 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604013232 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604013233 Condensation domain; Region: Condensation; pfam00668 713604013234 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013235 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013236 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013237 acyl-activating enzyme (AAE) consensus motif; other site 713604013238 AMP binding site [chemical binding]; other site 713604013239 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013240 Condensation domain; Region: Condensation; pfam00668 713604013241 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604013242 Condensation domain; Region: Condensation; pfam00668 713604013243 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013244 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013245 acyl-activating enzyme (AAE) consensus motif; other site 713604013246 AMP binding site [chemical binding]; other site 713604013247 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013248 Condensation domain; Region: Condensation; pfam00668 713604013249 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013250 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013251 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013252 acyl-activating enzyme (AAE) consensus motif; other site 713604013253 AMP binding site [chemical binding]; other site 713604013254 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013255 Condensation domain; Region: Condensation; pfam00668 713604013256 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013257 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013258 Condensation domain; Region: Condensation; pfam00668 713604013259 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604013260 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604013261 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604013262 MbtH-like protein; Region: MbtH; cl01279 713604013263 Condensation domain; Region: Condensation; pfam00668 713604013264 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013265 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013266 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013267 Condensation domain; Region: Condensation; pfam00668 713604013268 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013269 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013270 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013271 acyl-activating enzyme (AAE) consensus motif; other site 713604013272 AMP binding site [chemical binding]; other site 713604013273 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013274 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013275 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013276 acyl-activating enzyme (AAE) consensus motif; other site 713604013277 AMP binding site [chemical binding]; other site 713604013278 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013279 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 713604013280 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 713604013281 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604013282 allantoate amidohydrolase; Reviewed; Region: PRK09290 713604013283 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 713604013284 active site 713604013285 metal binding site [ion binding]; metal-binding site 713604013286 dimer interface [polypeptide binding]; other site 713604013287 Helix-turn-helix domain; Region: HTH_20; pfam12840 713604013288 Methyltransferase domain; Region: Methyltransf_18; pfam12847 713604013289 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604013290 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604013291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604013292 homodimer interface [polypeptide binding]; other site 713604013293 catalytic residue [active] 713604013294 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604013295 Predicted ATPase [General function prediction only]; Region: COG3903 713604013296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604013297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604013298 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 713604013299 putative substrate binding pocket [chemical binding]; other site 713604013300 putative dimerization interface [polypeptide binding]; other site 713604013301 hypothetical protein; Provisional; Region: PRK07236 713604013302 FAD binding domain; Region: FAD_binding_3; pfam01494 713604013303 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 713604013304 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604013305 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604013306 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604013307 NIPSNAP; Region: NIPSNAP; pfam07978 713604013308 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 713604013309 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 713604013310 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604013311 active site pocket [active] 713604013312 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604013313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604013314 DNA-binding site [nucleotide binding]; DNA binding site 713604013315 FCD domain; Region: FCD; pfam07729 713604013316 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604013317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604013318 dimer interface [polypeptide binding]; other site 713604013319 conserved gate region; other site 713604013320 ABC-ATPase subunit interface; other site 713604013321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604013322 dimer interface [polypeptide binding]; other site 713604013323 conserved gate region; other site 713604013324 putative PBP binding loops; other site 713604013325 ABC-ATPase subunit interface; other site 713604013326 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604013327 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 713604013328 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604013329 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604013330 MbtH-like protein; Region: MbtH; cl01279 713604013331 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013332 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013333 acyl-activating enzyme (AAE) consensus motif; other site 713604013334 AMP binding site [chemical binding]; other site 713604013335 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013336 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 713604013337 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604013338 dimer interface [polypeptide binding]; other site 713604013339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604013340 catalytic residue [active] 713604013341 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 713604013342 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 713604013343 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 713604013344 B12 binding site [chemical binding]; other site 713604013345 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 713604013346 substrate binding site [chemical binding]; other site 713604013347 B12 cofactor binding site [chemical binding]; other site 713604013348 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 713604013349 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 713604013350 aspartate racemase; Region: asp_race; TIGR00035 713604013351 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 713604013352 Condensation domain; Region: Condensation; pfam00668 713604013353 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013354 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013355 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013356 acyl-activating enzyme (AAE) consensus motif; other site 713604013357 AMP binding site [chemical binding]; other site 713604013358 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013359 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 713604013360 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013361 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013362 acyl-activating enzyme (AAE) consensus motif; other site 713604013363 AMP binding site [chemical binding]; other site 713604013364 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013365 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 713604013366 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 713604013367 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604013368 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 713604013369 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013370 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013371 acyl-activating enzyme (AAE) consensus motif; other site 713604013372 AMP binding site [chemical binding]; other site 713604013373 Condensation domain; Region: Condensation; pfam00668 713604013374 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013375 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013376 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013377 acyl-activating enzyme (AAE) consensus motif; other site 713604013378 AMP binding site [chemical binding]; other site 713604013379 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013380 Condensation domain; Region: Condensation; pfam00668 713604013381 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604013382 Condensation domain; Region: Condensation; pfam00668 713604013383 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013384 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604013385 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604013386 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604013387 DNA binding site [nucleotide binding] 713604013388 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604013389 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604013390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604013391 TPR motif; other site 713604013392 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604013393 binding surface 713604013394 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 713604013395 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604013396 DNA binding residues [nucleotide binding] 713604013397 putative dimer interface [polypeptide binding]; other site 713604013398 HEAT repeats; Region: HEAT_2; pfam13646 713604013399 Leishmanolysin; Region: Peptidase_M8; pfam01457 713604013400 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604013401 Switch II region; other site 713604013402 G4 box; other site 713604013403 G5 box; other site 713604013404 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 713604013405 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604013406 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604013407 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604013408 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604013409 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604013410 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604013411 putative sugar binding sites [chemical binding]; other site 713604013412 Q-X-W motif; other site 713604013413 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 713604013414 active site 713604013415 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604013416 Cytochrome P450; Region: p450; pfam00067 713604013417 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604013418 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604013419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604013420 S-adenosylmethionine binding site [chemical binding]; other site 713604013421 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604013422 MarR family; Region: MarR_2; pfam12802 713604013423 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604013424 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604013425 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 713604013426 Uncharacterized conserved protein [Function unknown]; Region: COG1359 713604013427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604013428 Histidine kinase; Region: HisKA_3; pfam07730 713604013429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604013430 ATP binding site [chemical binding]; other site 713604013431 Mg2+ binding site [ion binding]; other site 713604013432 G-X-G motif; other site 713604013433 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604013434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604013435 active site 713604013436 phosphorylation site [posttranslational modification] 713604013437 intermolecular recognition site; other site 713604013438 dimerization interface [polypeptide binding]; other site 713604013439 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604013440 DNA binding residues [nucleotide binding] 713604013441 dimerization interface [polypeptide binding]; other site 713604013442 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604013443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604013444 DNA binding residues [nucleotide binding] 713604013445 dimerization interface [polypeptide binding]; other site 713604013446 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 713604013447 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 713604013448 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 713604013449 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 713604013450 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 713604013451 metal ion-dependent adhesion site (MIDAS); other site 713604013452 potential frameshift: common BLAST hit: gi|256379384|ref|YP_003103044.1| FHA domain containing protein 713604013453 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 713604013454 phage tail protein domain; Region: tail_TIGR02242 713604013455 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 713604013456 PAAR motif; Region: PAAR_motif; pfam05488 713604013457 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 713604013458 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 713604013459 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 713604013460 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 713604013461 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 713604013462 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 713604013463 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 713604013464 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 713604013465 Phage-related protein [Function unknown]; Region: COG5412 713604013466 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 713604013467 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604013468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604013469 ATP binding site [chemical binding]; other site 713604013470 Walker A motif; other site 713604013471 Walker B motif; other site 713604013472 arginine finger; other site 713604013473 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 713604013474 Right handed beta helix region; Region: Beta_helix; pfam13229 713604013475 hypothetical protein; Provisional; Region: PRK08204 713604013476 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604013477 active site 713604013478 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 713604013479 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604013480 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604013481 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604013482 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604013483 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 713604013484 active site 713604013485 citrylCoA binding site [chemical binding]; other site 713604013486 oxalacetate binding site [chemical binding]; other site 713604013487 coenzyme A binding site [chemical binding]; other site 713604013488 catalytic triad [active] 713604013489 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 713604013490 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 713604013491 active site 713604013492 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604013493 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 713604013494 active site 713604013495 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 713604013496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013497 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 713604013498 Walker A/P-loop; other site 713604013499 ATP binding site [chemical binding]; other site 713604013500 Q-loop/lid; other site 713604013501 ABC transporter signature motif; other site 713604013502 Walker B; other site 713604013503 D-loop; other site 713604013504 H-loop/switch region; other site 713604013505 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604013506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013507 Walker A/P-loop; other site 713604013508 ATP binding site [chemical binding]; other site 713604013509 Q-loop/lid; other site 713604013510 ABC transporter signature motif; other site 713604013511 Walker B; other site 713604013512 D-loop; other site 713604013513 H-loop/switch region; other site 713604013514 hypothetical protein; Validated; Region: PRK05868 713604013515 hypothetical protein; Provisional; Region: PRK07236 713604013516 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604013517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604013518 short chain dehydrogenase; Provisional; Region: PRK06180 713604013519 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604013520 NADP binding site [chemical binding]; other site 713604013521 active site 713604013522 steroid binding site; other site 713604013523 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604013524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604013525 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604013526 dimerization interface [polypeptide binding]; other site 713604013527 substrate binding pocket [chemical binding]; other site 713604013528 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 713604013529 active site residue [active] 713604013530 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 713604013531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013532 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604013533 active site 713604013534 catalytic triad [active] 713604013535 oxyanion hole [active] 713604013536 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013537 putative DNA binding site [nucleotide binding]; other site 713604013538 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604013539 putative Zn2+ binding site [ion binding]; other site 713604013540 AsnC family; Region: AsnC_trans_reg; pfam01037 713604013541 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 713604013542 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 713604013543 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 713604013544 active site 713604013545 5'-3' exonuclease (including N-terminal domain of PolI) [DNA replication, recombination, and repair]; Region: Exo; COG0258 713604013546 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 713604013547 active site 713604013548 metal binding site 1 [ion binding]; metal-binding site 713604013549 putative 5' ssDNA interaction site; other site 713604013550 metal binding site 3; metal-binding site 713604013551 metal binding site 2 [ion binding]; metal-binding site 713604013552 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 713604013553 putative DNA binding site [nucleotide binding]; other site 713604013554 putative metal binding site [ion binding]; other site 713604013555 hypothetical protein; Provisional; Region: PRK01346 713604013556 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 713604013557 hypothetical protein; Provisional; Region: PRK01346 713604013558 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 713604013559 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 713604013560 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 713604013561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604013562 ATP binding site [chemical binding]; other site 713604013563 putative Mg++ binding site [ion binding]; other site 713604013564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604013565 nucleotide binding region [chemical binding]; other site 713604013566 ATP-binding site [chemical binding]; other site 713604013567 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 713604013568 diacylglycerol kinase; Reviewed; Region: PRK11914 713604013569 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 713604013570 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 713604013571 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 713604013572 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 713604013573 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604013574 WYL domain; Region: WYL; pfam13280 713604013575 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604013576 WYL domain; Region: WYL; pfam13280 713604013577 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604013578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013579 dimerization interface [polypeptide binding]; other site 713604013580 putative DNA binding site [nucleotide binding]; other site 713604013581 putative Zn2+ binding site [ion binding]; other site 713604013582 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604013583 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604013584 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604013585 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 713604013586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604013587 NAD(P) binding site [chemical binding]; other site 713604013588 active site 713604013589 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 713604013590 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 713604013591 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 713604013592 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 713604013593 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 713604013594 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 713604013595 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604013596 active site 713604013597 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 713604013598 active site 713604013599 Pup-like protein; Region: Pup; pfam05639 713604013600 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 713604013601 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 713604013602 nudix motif; other site 713604013603 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 713604013604 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604013605 active site 713604013606 catalytic tetrad [active] 713604013607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013608 dimerization interface [polypeptide binding]; other site 713604013609 putative DNA binding site [nucleotide binding]; other site 713604013610 putative Zn2+ binding site [ion binding]; other site 713604013611 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604013612 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 713604013613 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 713604013614 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 713604013615 EamA-like transporter family; Region: EamA; pfam00892 713604013616 proteasome ATPase; Region: pup_AAA; TIGR03689 713604013617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604013618 Walker A motif; other site 713604013619 ATP binding site [chemical binding]; other site 713604013620 Walker B motif; other site 713604013621 arginine finger; other site 713604013622 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 713604013623 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 713604013624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604013625 S-adenosylmethionine binding site [chemical binding]; other site 713604013626 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 713604013627 active site 713604013628 putative substrate binding region [chemical binding]; other site 713604013629 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 713604013630 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 713604013631 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 713604013632 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604013633 P-loop; other site 713604013634 Magnesium ion binding site [ion binding]; other site 713604013635 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604013636 Magnesium ion binding site [ion binding]; other site 713604013637 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 713604013638 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 713604013639 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 713604013640 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 713604013641 homodimer interface [polypeptide binding]; other site 713604013642 putative metal binding site [ion binding]; other site 713604013643 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 713604013644 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 713604013645 DNA binding site [nucleotide binding] 713604013646 active site 713604013647 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 713604013648 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 713604013649 AlkA N-terminal domain; Region: AlkA_N; pfam06029 713604013650 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 713604013651 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 713604013652 minor groove reading motif; other site 713604013653 helix-hairpin-helix signature motif; other site 713604013654 substrate binding pocket [chemical binding]; other site 713604013655 active site 713604013656 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 713604013657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604013658 motif II; other site 713604013659 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 713604013660 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 713604013661 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 713604013662 substrate binding pocket [chemical binding]; other site 713604013663 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 713604013664 B12 binding site [chemical binding]; other site 713604013665 cobalt ligand [ion binding]; other site 713604013666 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 713604013667 PAC2 family; Region: PAC2; pfam09754 713604013668 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604013669 active site 713604013670 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604013671 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604013672 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604013673 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604013674 active site 713604013675 metal binding site [ion binding]; metal-binding site 713604013676 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604013677 alkylmercury lyase; Provisional; Region: PRK13239 713604013678 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604013679 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604013680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 713604013681 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013682 dimerization interface [polypeptide binding]; other site 713604013683 putative DNA binding site [nucleotide binding]; other site 713604013684 putative Zn2+ binding site [ion binding]; other site 713604013685 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604013686 MarR family; Region: MarR_2; cl17246 713604013687 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 713604013688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013689 Walker A/P-loop; other site 713604013690 ATP binding site [chemical binding]; other site 713604013691 Q-loop/lid; other site 713604013692 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604013693 ABC transporter signature motif; other site 713604013694 Walker B; other site 713604013695 D-loop; other site 713604013696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013697 Walker A/P-loop; other site 713604013698 ATP binding site [chemical binding]; other site 713604013699 Q-loop/lid; other site 713604013700 ABC transporter signature motif; other site 713604013701 Walker B; other site 713604013702 D-loop; other site 713604013703 H-loop/switch region; other site 713604013704 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604013705 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 713604013706 active site 713604013707 HIGH motif; other site 713604013708 nucleotide binding site [chemical binding]; other site 713604013709 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604013710 active site 713604013711 KMSKS motif; other site 713604013712 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 713604013713 putative tRNA binding surface [nucleotide binding]; other site 713604013714 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604013715 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 713604013716 DNA binding residues [nucleotide binding] 713604013717 dimer interface [polypeptide binding]; other site 713604013718 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 713604013719 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604013720 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604013721 active site 713604013722 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 713604013723 Protein of unknown function, DUF484; Region: DUF484; cl17449 713604013724 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 713604013725 metal ion-dependent adhesion site (MIDAS); other site 713604013726 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 713604013727 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 713604013728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604013729 ferrochelatase; Reviewed; Region: hemH; PRK00035 713604013730 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 713604013731 C-terminal domain interface [polypeptide binding]; other site 713604013732 active site 713604013733 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 713604013734 active site 713604013735 N-terminal domain interface [polypeptide binding]; other site 713604013736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013738 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604013739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604013740 putative substrate translocation pore; other site 713604013741 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 713604013742 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 713604013743 NAD binding site [chemical binding]; other site 713604013744 homotetramer interface [polypeptide binding]; other site 713604013745 homodimer interface [polypeptide binding]; other site 713604013746 substrate binding site [chemical binding]; other site 713604013747 active site 713604013748 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 713604013749 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 713604013750 NAD(P) binding site [chemical binding]; other site 713604013751 homotetramer interface [polypeptide binding]; other site 713604013752 homodimer interface [polypeptide binding]; other site 713604013753 active site 713604013754 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 713604013755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604013756 putative substrate translocation pore; other site 713604013757 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604013758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604013759 active site 713604013760 phosphorylation site [posttranslational modification] 713604013761 intermolecular recognition site; other site 713604013762 dimerization interface [polypeptide binding]; other site 713604013763 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604013764 DNA binding site [nucleotide binding] 713604013765 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604013766 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604013767 dimerization interface [polypeptide binding]; other site 713604013768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604013769 dimer interface [polypeptide binding]; other site 713604013770 phosphorylation site [posttranslational modification] 713604013771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604013772 ATP binding site [chemical binding]; other site 713604013773 Mg2+ binding site [ion binding]; other site 713604013774 G-X-G motif; other site 713604013775 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 713604013776 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 713604013777 active site 713604013778 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 713604013779 hypothetical protein; Provisional; Region: PRK13685 713604013780 von Willebrand factor type A domain; Region: VWA_2; pfam13519 713604013781 metal ion-dependent adhesion site (MIDAS); other site 713604013782 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 713604013783 Protein of unknown function DUF58; Region: DUF58; pfam01882 713604013784 MoxR-like ATPases [General function prediction only]; Region: COG0714 713604013785 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 713604013786 ATP binding site [chemical binding]; other site 713604013787 Walker A motif; other site 713604013788 Walker B motif; other site 713604013789 arginine finger; other site 713604013790 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 713604013791 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 713604013792 GTP binding site; other site 713604013793 Methyltransferase domain; Region: Methyltransf_12; pfam08242 713604013794 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604013795 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604013796 aconitate hydratase; Validated; Region: PRK09277 713604013797 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 713604013798 substrate binding site [chemical binding]; other site 713604013799 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 713604013800 ligand binding site [chemical binding]; other site 713604013801 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 713604013802 substrate binding site [chemical binding]; other site 713604013803 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 713604013804 MgtC family; Region: MgtC; pfam02308 713604013805 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604013806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013808 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604013809 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604013810 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 713604013811 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 713604013812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604013813 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 713604013814 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 713604013815 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 713604013816 putative active site [active] 713604013817 putative dimer interface [polypeptide binding]; other site 713604013818 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 713604013819 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 713604013820 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604013821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604013822 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604013823 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604013824 putative dimerization interface [polypeptide binding]; other site 713604013825 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 713604013826 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 713604013827 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 713604013828 NAD(P) binding pocket [chemical binding]; other site 713604013829 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 713604013830 EspG family; Region: ESX-1_EspG; pfam14011 713604013831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013833 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 713604013834 Domain of unknown function DUF21; Region: DUF21; pfam01595 713604013835 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 713604013836 Transporter associated domain; Region: CorC_HlyC; smart01091 713604013837 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 713604013838 Domain of unknown function DUF21; Region: DUF21; pfam01595 713604013839 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 713604013840 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604013841 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604013842 active site 713604013843 catalytic tetrad [active] 713604013844 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604013845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604013846 non-specific DNA binding site [nucleotide binding]; other site 713604013847 salt bridge; other site 713604013848 sequence-specific DNA binding site [nucleotide binding]; other site 713604013849 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604013850 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 713604013851 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604013852 NAD binding site [chemical binding]; other site 713604013853 substrate binding site [chemical binding]; other site 713604013854 active site 713604013855 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 713604013856 Ligand binding site; other site 713604013857 Putative Catalytic site; other site 713604013858 DXD motif; other site 713604013859 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604013860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604013861 NAD(P) binding site [chemical binding]; other site 713604013862 active site 713604013863 glycine dehydrogenase; Provisional; Region: PRK05367 713604013864 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 713604013865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604013866 tetramer interface [polypeptide binding]; other site 713604013867 catalytic residue [active] 713604013868 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 713604013869 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604013870 catalytic residue [active] 713604013871 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 713604013872 DNA binding residues [nucleotide binding] 713604013873 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604013874 putative dimer interface [polypeptide binding]; other site 713604013875 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 713604013876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013877 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 713604013878 catalytic residues [active] 713604013879 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604013880 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 713604013881 DNA binding residues [nucleotide binding] 713604013882 putative dimer interface [polypeptide binding]; other site 713604013883 Bifunctional nuclease; Region: DNase-RNase; pfam02577 713604013884 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604013885 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604013886 DNA binding residues [nucleotide binding] 713604013887 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 713604013888 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 713604013889 phosphopeptide binding site; other site 713604013890 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 713604013891 lipoyl attachment site [posttranslational modification]; other site 713604013892 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 713604013893 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 713604013894 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 713604013895 active site 713604013896 acyl-activating enzyme (AAE) consensus motif; other site 713604013897 putative CoA binding site [chemical binding]; other site 713604013898 AMP binding site [chemical binding]; other site 713604013899 enoyl-CoA hydratase; Provisional; Region: PRK06142 713604013900 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604013901 substrate binding site [chemical binding]; other site 713604013902 oxyanion hole (OAH) forming residues; other site 713604013903 trimer interface [polypeptide binding]; other site 713604013904 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604013905 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604013906 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 713604013907 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 713604013908 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 713604013909 homodimer interface [polypeptide binding]; other site 713604013910 active site 713604013911 SAM binding site [chemical binding]; other site 713604013912 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 713604013913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604013914 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604013915 Walker A motif; other site 713604013916 ATP binding site [chemical binding]; other site 713604013917 Walker B motif; other site 713604013918 arginine finger; other site 713604013919 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 713604013920 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 713604013921 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 713604013922 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604013923 MarR family; Region: MarR; pfam01047 713604013924 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604013925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604013926 putative substrate translocation pore; other site 713604013927 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 713604013928 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604013929 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 713604013930 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 713604013931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604013932 catalytic residue [active] 713604013933 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 713604013934 MFS/sugar transport protein; Region: MFS_2; pfam13347 713604013935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604013936 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604013937 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 713604013938 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 713604013939 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013940 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013941 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604013942 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604013943 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604013944 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 713604013945 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 713604013946 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604013947 active site 713604013948 putative catalytic site [active] 713604013949 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 713604013950 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 713604013951 active site 713604013952 dimer interface [polypeptide binding]; other site 713604013953 non-prolyl cis peptide bond; other site 713604013954 insertion regions; other site 713604013955 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 713604013956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604013957 substrate binding pocket [chemical binding]; other site 713604013958 membrane-bound complex binding site; other site 713604013959 hinge residues; other site 713604013960 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604013961 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604013962 Walker A/P-loop; other site 713604013963 ATP binding site [chemical binding]; other site 713604013964 Q-loop/lid; other site 713604013965 ABC transporter signature motif; other site 713604013966 Walker B; other site 713604013967 D-loop; other site 713604013968 H-loop/switch region; other site 713604013969 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604013970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604013971 putative PBP binding loops; other site 713604013972 ABC-ATPase subunit interface; other site 713604013973 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 713604013974 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604013975 active site 713604013976 motif 3; other site 713604013977 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 713604013978 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604013979 DinB superfamily; Region: DinB_2; pfam12867 713604013980 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604013981 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604013982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013983 Walker A/P-loop; other site 713604013984 ATP binding site [chemical binding]; other site 713604013985 Q-loop/lid; other site 713604013986 ABC transporter signature motif; other site 713604013987 Walker B; other site 713604013988 D-loop; other site 713604013989 H-loop/switch region; other site 713604013990 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604013991 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604013992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013993 Walker A/P-loop; other site 713604013994 ATP binding site [chemical binding]; other site 713604013995 Q-loop/lid; other site 713604013996 ABC transporter signature motif; other site 713604013997 Walker B; other site 713604013998 D-loop; other site 713604013999 H-loop/switch region; other site 713604014000 MbtH-like protein; Region: MbtH; cl01279 713604014001 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 713604014002 intersubunit interface [polypeptide binding]; other site 713604014003 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 713604014004 tetramerization interface [polypeptide binding]; other site 713604014005 active site 713604014006 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604014007 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604014008 acyl-activating enzyme (AAE) consensus motif; other site 713604014009 AMP binding site [chemical binding]; other site 713604014010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604014011 S-adenosylmethionine binding site [chemical binding]; other site 713604014012 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014013 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014014 Condensation domain; Region: Condensation; pfam00668 713604014015 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604014016 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604014017 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604014018 acyl-activating enzyme (AAE) consensus motif; other site 713604014019 AMP binding site [chemical binding]; other site 713604014020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604014021 S-adenosylmethionine binding site [chemical binding]; other site 713604014022 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014023 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014024 Condensation domain; Region: Condensation; pfam00668 713604014025 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604014026 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604014027 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604014028 acyl-activating enzyme (AAE) consensus motif; other site 713604014029 AMP binding site [chemical binding]; other site 713604014030 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 713604014031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604014032 S-adenosylmethionine binding site [chemical binding]; other site 713604014033 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014034 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014035 Condensation domain; Region: Condensation; pfam00668 713604014036 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604014037 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604014038 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604014039 acyl-activating enzyme (AAE) consensus motif; other site 713604014040 AMP binding site [chemical binding]; other site 713604014041 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014042 Condensation domain; Region: Condensation; pfam00668 713604014043 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604014044 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604014045 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604014046 acyl-activating enzyme (AAE) consensus motif; other site 713604014047 AMP binding site [chemical binding]; other site 713604014048 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014049 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 713604014050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 713604014051 ABC-ATPase subunit interface; other site 713604014052 dimer interface [polypeptide binding]; other site 713604014053 putative PBP binding regions; other site 713604014054 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 713604014055 ABC-ATPase subunit interface; other site 713604014056 dimer interface [polypeptide binding]; other site 713604014057 putative PBP binding regions; other site 713604014058 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 713604014059 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 713604014060 Walker A/P-loop; other site 713604014061 ATP binding site [chemical binding]; other site 713604014062 Q-loop/lid; other site 713604014063 ABC transporter signature motif; other site 713604014064 Walker B; other site 713604014065 D-loop; other site 713604014066 H-loop/switch region; other site 713604014067 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604014068 DinB superfamily; Region: DinB_2; pfam12867 713604014069 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 713604014070 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604014071 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 713604014072 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 713604014073 active site 713604014074 substrate binding site [chemical binding]; other site 713604014075 cosubstrate binding site; other site 713604014076 catalytic site [active] 713604014077 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 713604014078 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 713604014079 Melibiase; Region: Melibiase; pfam02065 713604014080 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604014081 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604014082 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604014083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014084 putative PBP binding loops; other site 713604014085 ABC-ATPase subunit interface; other site 713604014086 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604014087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014088 dimer interface [polypeptide binding]; other site 713604014089 conserved gate region; other site 713604014090 putative PBP binding loops; other site 713604014091 ABC-ATPase subunit interface; other site 713604014092 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 713604014093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604014094 Walker A/P-loop; other site 713604014095 ATP binding site [chemical binding]; other site 713604014096 Q-loop/lid; other site 713604014097 ABC transporter signature motif; other site 713604014098 Walker B; other site 713604014099 D-loop; other site 713604014100 H-loop/switch region; other site 713604014101 ABC transporter; Region: ABC_tran_2; pfam12848 713604014102 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604014103 PaaX-like protein; Region: PaaX; pfam07848 713604014104 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 713604014105 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604014106 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604014107 substrate binding site [chemical binding]; other site 713604014108 oxyanion hole (OAH) forming residues; other site 713604014109 trimer interface [polypeptide binding]; other site 713604014110 CBD_II domain; Region: CBD_II; smart00637 713604014111 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604014112 Interdomain contacts; other site 713604014113 Cytokine receptor motif; other site 713604014114 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604014115 Interdomain contacts; other site 713604014116 Cytokine receptor motif; other site 713604014117 Glyco_18 domain; Region: Glyco_18; smart00636 713604014118 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 713604014119 active site 713604014120 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604014121 DNA binding site [nucleotide binding] 713604014122 active site 713604014123 Int/Topo IB signature motif; other site 713604014124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604014125 Transposase; Region: HTH_Tnp_1; pfam01527 713604014126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 713604014127 HTH-like domain; Region: HTH_21; pfam13276 713604014128 Integrase core domain; Region: rve; pfam00665 713604014129 Integrase core domain; Region: rve_3; pfam13683 713604014130 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 713604014131 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604014132 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 713604014133 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604014134 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014135 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014136 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014137 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014138 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014139 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014140 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014141 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604014143 binding surface 713604014144 TPR motif; other site 713604014145 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604014147 binding surface 713604014148 TPR motif; other site 713604014149 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014150 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604014152 binding surface 713604014153 TPR motif; other site 713604014154 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014155 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604014156 DNA binding site [nucleotide binding] 713604014157 Int/Topo IB signature motif; other site 713604014158 active site 713604014159 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 713604014160 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604014161 active site 713604014162 metal binding site [ion binding]; metal-binding site 713604014163 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 713604014164 active site 713604014165 catalytic residues [active] 713604014166 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 713604014167 MarR family; Region: MarR_2; pfam12802 713604014168 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604014169 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604014170 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 713604014171 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 713604014172 active site 713604014173 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604014174 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604014175 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604014176 Cellulose binding domain; Region: CBM_2; cl17741 713604014177 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 713604014178 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604014179 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 713604014180 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604014181 DNA interaction; other site 713604014182 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604014183 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 713604014184 metal binding site [ion binding]; metal-binding site 713604014185 substrate binding pocket [chemical binding]; other site 713604014186 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 713604014187 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604014188 DNA binding site [nucleotide binding] 713604014189 domain linker motif; other site 713604014190 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604014191 dimerization interface [polypeptide binding]; other site 713604014192 ligand binding site [chemical binding]; other site 713604014193 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 713604014194 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604014195 metal binding site [ion binding]; metal-binding site 713604014196 substrate binding pocket [chemical binding]; other site 713604014197 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604014198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014199 dimer interface [polypeptide binding]; other site 713604014200 conserved gate region; other site 713604014201 putative PBP binding loops; other site 713604014202 ABC-ATPase subunit interface; other site 713604014203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 713604014204 NMT1/THI5 like; Region: NMT1; pfam09084 713604014205 substrate binding pocket [chemical binding]; other site 713604014206 membrane-bound complex binding site; other site 713604014207 hinge residues; other site 713604014208 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604014209 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604014210 Walker A/P-loop; other site 713604014211 ATP binding site [chemical binding]; other site 713604014212 Q-loop/lid; other site 713604014213 ABC transporter signature motif; other site 713604014214 Walker B; other site 713604014215 D-loop; other site 713604014216 H-loop/switch region; other site 713604014217 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604014218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604014219 dimerization interface [polypeptide binding]; other site 713604014220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604014221 dimer interface [polypeptide binding]; other site 713604014222 phosphorylation site [posttranslational modification] 713604014223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604014224 Mg2+ binding site [ion binding]; other site 713604014225 G-X-G motif; other site 713604014226 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604014227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604014228 active site 713604014229 phosphorylation site [posttranslational modification] 713604014230 intermolecular recognition site; other site 713604014231 dimerization interface [polypeptide binding]; other site 713604014232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604014233 DNA binding site [nucleotide binding] 713604014234 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604014235 MarR family; Region: MarR_2; pfam12802 713604014236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604014237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014238 putative substrate translocation pore; other site 713604014239 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604014240 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604014241 MarR family; Region: MarR_2; cl17246 713604014242 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 713604014243 amphipathic channel; other site 713604014244 Asn-Pro-Ala signature motifs; other site 713604014245 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604014246 iron-sulfur cluster [ion binding]; other site 713604014247 [2Fe-2S] cluster binding site [ion binding]; other site 713604014248 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 713604014249 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 713604014250 PYR/PP interface [polypeptide binding]; other site 713604014251 dimer interface [polypeptide binding]; other site 713604014252 tetramer interface [polypeptide binding]; other site 713604014253 TPP binding site [chemical binding]; other site 713604014254 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604014255 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604014256 TPP-binding site [chemical binding]; other site 713604014257 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604014258 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604014259 classical (c) SDRs; Region: SDR_c; cd05233 713604014260 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604014261 NAD(P) binding site [chemical binding]; other site 713604014262 active site 713604014263 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 713604014264 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604014265 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604014266 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 713604014267 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604014268 active site 713604014269 metal binding site [ion binding]; metal-binding site 713604014270 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604014271 active site 713604014272 metal binding site [ion binding]; metal-binding site 713604014273 hypothetical protein; Provisional; Region: PRK06847 713604014274 hypothetical protein; Provisional; Region: PRK07236 713604014275 Putative cyclase; Region: Cyclase; pfam04199 713604014276 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604014277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604014278 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 713604014279 substrate binding pocket [chemical binding]; other site 713604014280 dimerization interface [polypeptide binding]; other site 713604014281 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604014282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014283 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604014284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604014285 Walker A/P-loop; other site 713604014286 ATP binding site [chemical binding]; other site 713604014287 Q-loop/lid; other site 713604014288 ABC transporter signature motif; other site 713604014289 Walker B; other site 713604014290 D-loop; other site 713604014291 H-loop/switch region; other site 713604014292 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604014293 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604014294 TM-ABC transporter signature motif; other site 713604014295 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604014296 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604014297 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604014298 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604014299 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604014300 DNA binding residues [nucleotide binding] 713604014301 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 713604014302 peptidase domain interface [polypeptide binding]; other site 713604014303 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604014304 active site 713604014305 catalytic triad [active] 713604014306 calcium binding site [ion binding]; other site 713604014307 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 713604014308 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604014309 active site 713604014310 catalytic triad [active] 713604014311 oxyanion hole [active] 713604014312 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 713604014313 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 713604014314 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604014315 active site 713604014316 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 713604014317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604014318 FeS/SAM binding site; other site 713604014319 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604014320 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604014321 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 713604014322 active site 713604014323 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 713604014324 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604014325 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604014326 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604014327 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604014328 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604014329 Cytochrome P450; Region: p450; cl12078 713604014330 CsbD-like; Region: CsbD; pfam05532 713604014331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604014332 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 713604014333 NAD(P) binding site [chemical binding]; other site 713604014334 active site 713604014335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604014336 sequence-specific DNA binding site [nucleotide binding]; other site 713604014337 salt bridge; other site 713604014338 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604014339 G1 box; other site 713604014340 GTP/Mg2+ binding site [chemical binding]; other site 713604014341 G2 box; other site 713604014342 Switch I region; other site 713604014343 G3 box; other site 713604014344 Switch II region; other site 713604014345 G4 box; other site 713604014346 G5 box; other site 713604014347 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 713604014348 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 713604014349 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 713604014350 selenocysteine synthase; Provisional; Region: PRK04311 713604014351 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604014352 potential protein location (hypothetical protein RAM_26065 [Amycolatopsis mediterranei S699]) that overlaps RNA (tRNA-U) 713604014353 selenium donor protein; Region: selD; TIGR00476 713604014354 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 713604014355 dimerization interface [polypeptide binding]; other site 713604014356 putative ATP binding site [chemical binding]; other site 713604014357 hypothetical protein; Provisional; Region: PRK06771 713604014358 Isochorismatase family; Region: Isochorismatase; pfam00857 713604014359 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 713604014360 catalytic triad [active] 713604014361 conserved cis-peptide bond; other site 713604014362 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 713604014363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604014364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604014365 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 713604014366 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 713604014367 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 713604014368 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604014369 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604014370 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 713604014371 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604014372 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604014373 Predicted membrane protein [Function unknown]; Region: COG2259 713604014374 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 713604014375 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604014376 putative active site [active] 713604014377 putative metal binding site [ion binding]; other site 713604014378 Peptidase M15; Region: Peptidase_M15_3; cl01194 713604014379 haloalkane dehalogenase; Provisional; Region: PRK03592 713604014380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604014381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014382 RibD C-terminal domain; Region: RibD_C; cl17279 713604014383 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604014384 Sulfatase; Region: Sulfatase; cl17466 713604014385 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 713604014386 VanZ like family; Region: VanZ; pfam04892 713604014387 RDD family; Region: RDD; pfam06271 713604014388 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604014389 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 713604014390 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604014391 anti sigma factor interaction site; other site 713604014392 regulatory phosphorylation site [posttranslational modification]; other site 713604014393 MMPL family; Region: MMPL; pfam03176 713604014394 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604014395 MarR family; Region: MarR_2; pfam12802 713604014396 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 713604014397 spermidine synthase; Provisional; Region: PRK00811 713604014398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604014399 S-adenosylmethionine binding site [chemical binding]; other site 713604014400 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 713604014401 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 713604014402 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 713604014403 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604014404 catalytic residue [active] 713604014405 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 713604014406 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604014407 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604014408 putative sugar binding sites [chemical binding]; other site 713604014409 Q-X-W motif; other site 713604014410 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 713604014411 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 713604014412 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604014413 MarR family; Region: MarR_2; cl17246 713604014414 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 713604014415 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014416 acyl-activating enzyme (AAE) consensus motif; other site 713604014417 active site 713604014418 AMP binding site [chemical binding]; other site 713604014419 CoA binding site [chemical binding]; other site 713604014420 TPR repeat; Region: TPR_11; pfam13414 713604014421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604014422 binding surface 713604014423 TPR motif; other site 713604014424 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 713604014425 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604014426 anti sigma factor interaction site; other site 713604014427 regulatory phosphorylation site [posttranslational modification]; other site 713604014428 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 713604014429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604014430 active site 713604014431 phosphorylation site [posttranslational modification] 713604014432 intermolecular recognition site; other site 713604014433 dimerization interface [polypeptide binding]; other site 713604014434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604014435 PAS domain; Region: PAS_9; pfam13426 713604014436 putative active site [active] 713604014437 heme pocket [chemical binding]; other site 713604014438 PAS domain S-box; Region: sensory_box; TIGR00229 713604014439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604014440 putative active site [active] 713604014441 heme pocket [chemical binding]; other site 713604014442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604014443 Histidine kinase; Region: HisKA_3; pfam07730 713604014444 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604014445 ATP binding site [chemical binding]; other site 713604014446 Mg2+ binding site [ion binding]; other site 713604014447 G-X-G motif; other site 713604014448 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604014449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604014450 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604014451 DNA binding residues [nucleotide binding] 713604014452 dimerization interface [polypeptide binding]; other site 713604014453 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 713604014454 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 713604014455 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 713604014456 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 713604014457 nucleotide binding site [chemical binding]; other site 713604014458 putative NEF/HSP70 interaction site [polypeptide binding]; other site 713604014459 SBD interface [polypeptide binding]; other site 713604014460 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604014461 Dynamin family; Region: Dynamin_N; pfam00350 713604014462 G1 box; other site 713604014463 GTP/Mg2+ binding site [chemical binding]; other site 713604014464 G2 box; other site 713604014465 Switch I region; other site 713604014466 G3 box; other site 713604014467 Switch II region; other site 713604014468 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 713604014469 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 713604014470 Dynamin family; Region: Dynamin_N; pfam00350 713604014471 G1 box; other site 713604014472 G1 box; other site 713604014473 GTP/Mg2+ binding site [chemical binding]; other site 713604014474 GTP/Mg2+ binding site [chemical binding]; other site 713604014475 G2 box; other site 713604014476 Switch I region; other site 713604014477 G3 box; other site 713604014478 Switch II region; other site 713604014479 G4 box; other site 713604014480 G5 box; other site 713604014481 Predicted ATPase [General function prediction only]; Region: COG3899 713604014482 AAA ATPase domain; Region: AAA_16; pfam13191 713604014483 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604014484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604014485 DNA binding residues [nucleotide binding] 713604014486 dimerization interface [polypeptide binding]; other site 713604014487 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 713604014488 active site 713604014489 catalytic site [active] 713604014490 hypothetical protein; Provisional; Region: PRK07236 713604014491 hypothetical protein; Provisional; Region: PRK07588 713604014492 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 713604014493 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 713604014494 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 713604014495 substrate binding pocket [chemical binding]; other site 713604014496 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 713604014497 B12 binding site [chemical binding]; other site 713604014498 cobalt ligand [ion binding]; other site 713604014499 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 713604014500 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604014501 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604014502 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 713604014503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014504 putative substrate translocation pore; other site 713604014505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014506 Cellulose binding domain; Region: CBM_2; pfam00553 713604014507 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 713604014508 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604014509 putative NAD(P) binding site [chemical binding]; other site 713604014510 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 713604014511 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 713604014512 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604014513 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 713604014514 Cellulose binding domain; Region: CBM_2; pfam00553 713604014515 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604014516 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604014517 active site 713604014518 catalytic tetrad [active] 713604014519 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 713604014520 putative active cleft [active] 713604014521 dimerization interface [polypeptide binding]; other site 713604014522 Chitin binding domain; Region: Chitin_bind_3; pfam03067 713604014523 Cellulose binding domain; Region: CBM_2; pfam00553 713604014524 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604014525 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604014526 DNA binding site [nucleotide binding] 713604014527 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604014528 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 713604014529 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604014530 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604014531 Cellulose binding domain; Region: CBM_2; pfam00553 713604014532 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 713604014533 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 713604014534 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 713604014535 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604014536 Cellulose binding domain; Region: CBM_2; pfam00553 713604014537 Cellulose binding domain; Region: CBM_2; pfam00553 713604014538 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 713604014539 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604014540 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604014541 DNA binding site [nucleotide binding] 713604014542 domain linker motif; other site 713604014543 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604014544 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604014545 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604014546 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604014547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014548 dimer interface [polypeptide binding]; other site 713604014549 conserved gate region; other site 713604014550 ABC-ATPase subunit interface; other site 713604014551 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604014552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014553 dimer interface [polypeptide binding]; other site 713604014554 conserved gate region; other site 713604014555 putative PBP binding loops; other site 713604014556 ABC-ATPase subunit interface; other site 713604014557 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604014558 beta-galactosidase; Region: BGL; TIGR03356 713604014559 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 713604014560 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 713604014561 FOG: CBS domain [General function prediction only]; Region: COG0517 713604014562 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 713604014563 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 713604014564 Fe-S cluster binding site [ion binding]; other site 713604014565 active site 713604014566 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 713604014567 nucleotide binding site [chemical binding]; other site 713604014568 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 713604014569 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 713604014570 active site 713604014571 DNA binding site [nucleotide binding] 713604014572 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 713604014573 DNA binding site [nucleotide binding] 713604014574 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 713604014575 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 713604014576 putative DNA binding site [nucleotide binding]; other site 713604014577 putative homodimer interface [polypeptide binding]; other site 713604014578 GAF domain; Region: GAF_2; pfam13185 713604014579 GAF domain; Region: GAF; pfam01590 713604014580 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 713604014581 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604014582 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 713604014583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604014584 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604014585 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 713604014586 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604014587 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604014588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604014589 DNA binding residues [nucleotide binding] 713604014590 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 713604014591 putative active site; other site 713604014592 putative metal binding residues [ion binding]; other site 713604014593 signature motif; other site 713604014594 putative triphosphate binding site [ion binding]; other site 713604014595 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 713604014596 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 713604014597 ANTAR domain; Region: ANTAR; pfam03861 713604014598 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 713604014599 putative hydrophobic ligand binding site [chemical binding]; other site 713604014600 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 713604014601 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 713604014602 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604014603 anti sigma factor interaction site; other site 713604014604 regulatory phosphorylation site [posttranslational modification]; other site 713604014605 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 713604014606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604014607 Amidinotransferase; Region: Amidinotransf; cl12043 713604014608 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604014609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604014610 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604014611 dimerization interface [polypeptide binding]; other site 713604014612 substrate binding pocket [chemical binding]; other site 713604014613 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 713604014614 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 713604014615 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604014616 catalytic residue [active] 713604014617 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 713604014618 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 713604014619 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 713604014620 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 713604014621 active site 713604014622 catalytic triad [active] 713604014623 oxyanion hole [active] 713604014624 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604014625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014626 putative substrate translocation pore; other site 713604014627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604014628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604014629 Coenzyme A binding pocket [chemical binding]; other site 713604014630 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604014631 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604014632 RHS Repeat; Region: RHS_repeat; pfam05593 713604014633 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604014634 RHS Repeat; Region: RHS_repeat; pfam05593 713604014635 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604014636 RHS Repeat; Region: RHS_repeat; cl11982 713604014637 RHS Repeat; Region: RHS_repeat; pfam05593 713604014638 RHS protein; Region: RHS; pfam03527 713604014639 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604014640 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 713604014641 EspG family; Region: ESX-1_EspG; pfam14011 713604014642 Domain of unknown function (DUF222); Region: DUF222; pfam02720 713604014643 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604014644 active site 713604014645 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 713604014646 Flavin Reductases; Region: FlaRed; cl00801 713604014647 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604014648 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 713604014649 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604014650 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 713604014651 catalytic loop [active] 713604014652 iron binding site [ion binding]; other site 713604014653 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604014654 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604014655 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604014656 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604014657 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 713604014658 RibD C-terminal domain; Region: RibD_C; cl17279 713604014659 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604014660 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014661 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604014662 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604014663 DNA binding site [nucleotide binding] 713604014664 domain linker motif; other site 713604014665 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604014666 dimerization interface [polypeptide binding]; other site 713604014667 ligand binding site [chemical binding]; other site 713604014668 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014669 sugar binding site [chemical binding]; other site 713604014670 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014671 sugar binding site [chemical binding]; other site 713604014672 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604014673 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604014674 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604014675 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604014676 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014677 sugar binding site [chemical binding]; other site 713604014678 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014679 sugar binding site [chemical binding]; other site 713604014680 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 713604014681 active site 713604014682 catalytic residues [active] 713604014683 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014684 sugar binding site [chemical binding]; other site 713604014685 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 713604014686 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604014687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604014688 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604014689 MarR family; Region: MarR; pfam01047 713604014690 MarR family; Region: MarR_2; cl17246 713604014691 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 713604014692 dimerization interface [polypeptide binding]; other site 713604014693 active site 713604014694 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 713604014695 substrate binding site [chemical binding]; other site 713604014696 THF binding site; other site 713604014697 zinc-binding site [ion binding]; other site 713604014698 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 713604014699 DNA polymerase IV; Validated; Region: PRK03352 713604014700 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 713604014701 active site 713604014702 DNA binding site [nucleotide binding] 713604014703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604014704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014705 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 713604014706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604014707 Coenzyme A binding pocket [chemical binding]; other site 713604014708 Adenosylhomocysteinase; Provisional; Region: PTZ00075 713604014709 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 713604014710 homotetramer interface [polypeptide binding]; other site 713604014711 ligand binding site [chemical binding]; other site 713604014712 catalytic site [active] 713604014713 NAD binding site [chemical binding]; other site 713604014714 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 713604014715 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 713604014716 putative DNA binding site [nucleotide binding]; other site 713604014717 putative homodimer interface [polypeptide binding]; other site 713604014718 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604014719 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604014720 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604014721 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604014722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604014723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604014724 ATP binding site [chemical binding]; other site 713604014725 Mg2+ binding site [ion binding]; other site 713604014726 G-X-G motif; other site 713604014727 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604014728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014729 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604014730 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604014731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604014732 Walker A/P-loop; other site 713604014733 ATP binding site [chemical binding]; other site 713604014734 Q-loop/lid; other site 713604014735 ABC transporter signature motif; other site 713604014736 Walker B; other site 713604014737 D-loop; other site 713604014738 H-loop/switch region; other site 713604014739 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604014740 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604014741 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 713604014742 Walker A/P-loop; other site 713604014743 ATP binding site [chemical binding]; other site 713604014744 Q-loop/lid; other site 713604014745 ABC transporter signature motif; other site 713604014746 Walker B; other site 713604014747 D-loop; other site 713604014748 H-loop/switch region; other site 713604014749 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 713604014750 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 713604014751 active site 713604014752 DNA binding site [nucleotide binding] 713604014753 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604014754 AAA ATPase domain; Region: AAA_16; pfam13191 713604014755 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 713604014756 conserved cys residue [active] 713604014757 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 713604014758 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604014759 conserved cys residue [active] 713604014760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604014761 YibE/F-like protein; Region: YibE_F; pfam07907 713604014762 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 713604014763 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 713604014764 active site 713604014765 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 713604014766 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 713604014767 AAA domain; Region: AAA_17; pfam13207 713604014768 enoyl-CoA hydratase; Provisional; Region: PRK06127 713604014769 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604014770 substrate binding site [chemical binding]; other site 713604014771 oxyanion hole (OAH) forming residues; other site 713604014772 trimer interface [polypeptide binding]; other site 713604014773 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604014774 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604014775 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604014776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604014777 DNA binding residues [nucleotide binding] 713604014778 dimerization interface [polypeptide binding]; other site 713604014779 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 713604014780 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 713604014781 MarR family; Region: MarR_2; pfam12802 713604014782 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604014783 hypothetical protein; Provisional; Region: PRK08204 713604014784 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604014785 active site 713604014786 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 713604014787 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604014788 Zn2+ binding site [ion binding]; other site 713604014789 Mg2+ binding site [ion binding]; other site 713604014790 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 713604014791 synthetase active site [active] 713604014792 NTP binding site [chemical binding]; other site 713604014793 metal binding site [ion binding]; metal-binding site 713604014794 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 713604014795 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 713604014796 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604014797 active site 713604014798 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 713604014799 Protein export membrane protein; Region: SecD_SecF; cl14618 713604014800 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 713604014801 Protein export membrane protein; Region: SecD_SecF; cl14618 713604014802 Preprotein translocase subunit; Region: YajC; cl00806 713604014803 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 713604014804 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604014805 Walker A motif; other site 713604014806 ATP binding site [chemical binding]; other site 713604014807 Walker B motif; other site 713604014808 arginine finger; other site 713604014809 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 713604014810 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 713604014811 RuvA N terminal domain; Region: RuvA_N; pfam01330 713604014812 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 713604014813 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 713604014814 active site 713604014815 putative DNA-binding cleft [nucleotide binding]; other site 713604014816 dimer interface [polypeptide binding]; other site 713604014817 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 713604014818 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 713604014819 hypothetical protein; Validated; Region: PRK00110 713604014820 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 713604014821 predicted active site [active] 713604014822 catalytic triad [active] 713604014823 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 713604014824 AzlC protein; Region: AzlC; pfam03591 713604014825 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604014826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604014827 non-specific DNA binding site [nucleotide binding]; other site 713604014828 salt bridge; other site 713604014829 sequence-specific DNA binding site [nucleotide binding]; other site 713604014830 Cupin domain; Region: Cupin_2; cl17218 713604014831 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 713604014832 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604014833 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604014834 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604014835 active site 713604014836 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604014837 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014838 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604014839 acyl-activating enzyme (AAE) consensus motif; other site 713604014840 AMP binding site [chemical binding]; other site 713604014841 active site 713604014842 CoA binding site [chemical binding]; other site 713604014843 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014844 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604014845 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 713604014846 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 713604014847 active site 713604014848 multimer interface [polypeptide binding]; other site 713604014849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604014850 putative Zn2+ binding site [ion binding]; other site 713604014851 putative DNA binding site [nucleotide binding]; other site 713604014852 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604014853 FAD binding domain; Region: FAD_binding_4; pfam01565 713604014854 Berberine and berberine like; Region: BBE; pfam08031 713604014855 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 713604014856 elongation factor G; Reviewed; Region: PRK12740 713604014857 G1 box; other site 713604014858 putative GEF interaction site [polypeptide binding]; other site 713604014859 GTP/Mg2+ binding site [chemical binding]; other site 713604014860 Switch I region; other site 713604014861 G2 box; other site 713604014862 G3 box; other site 713604014863 Switch II region; other site 713604014864 G4 box; other site 713604014865 G5 box; other site 713604014866 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 713604014867 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 713604014868 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 713604014869 XdhC Rossmann domain; Region: XdhC_C; pfam13478 713604014870 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604014871 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604014872 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 713604014873 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 713604014874 putative acyl-acceptor binding pocket; other site 713604014875 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 713604014876 MarR family; Region: MarR_2; pfam12802 713604014877 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 713604014878 nucleotide binding site/active site [active] 713604014879 HIT family signature motif; other site 713604014880 catalytic residue [active] 713604014881 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 713604014882 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 713604014883 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 713604014884 active site 713604014885 dimer interface [polypeptide binding]; other site 713604014886 motif 1; other site 713604014887 motif 2; other site 713604014888 motif 3; other site 713604014889 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 713604014890 anticodon binding site; other site 713604014891 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 713604014892 putative FMN binding site [chemical binding]; other site 713604014893 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 713604014894 Bacterial sugar transferase; Region: Bac_transf; pfam02397 713604014895 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 713604014896 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604014897 active site 713604014898 DNA binding site [nucleotide binding] 713604014899 Int/Topo IB signature motif; other site 713604014900 Lsr2; Region: Lsr2; pfam11774 713604014901 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604014902 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604014903 Peptidase family M41; Region: Peptidase_M41; pfam01434 713604014904 Predicted membrane protein [Function unknown]; Region: COG4280 713604014905 Predicted permease; Region: DUF318; pfam03773 713604014906 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 713604014907 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604014908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014909 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604014910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604014911 NAD(P) binding site [chemical binding]; other site 713604014912 active site 713604014913 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604014914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604014915 substrate binding site [chemical binding]; other site 713604014916 oxyanion hole (OAH) forming residues; other site 713604014917 trimer interface [polypeptide binding]; other site 713604014918 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 713604014919 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014920 acyl-activating enzyme (AAE) consensus motif; other site 713604014921 AMP binding site [chemical binding]; other site 713604014922 active site 713604014923 CoA binding site [chemical binding]; other site 713604014924 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 713604014925 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604014926 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 713604014927 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 713604014928 metal binding site [ion binding]; metal-binding site 713604014929 dimer interface [polypeptide binding]; other site 713604014930 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604014931 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604014932 AsnC family; Region: AsnC_trans_reg; pfam01037 713604014933 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604014934 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604014935 AsnC family; Region: AsnC_trans_reg; pfam01037 713604014936 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604014937 MarR family; Region: MarR_2; pfam12802 713604014938 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604014939 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604014940 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604014941 active site 713604014942 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604014943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604014944 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604014945 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 713604014946 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 713604014947 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604014948 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604014949 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014950 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 713604014951 acyl-activating enzyme (AAE) consensus motif; other site 713604014952 putative AMP binding site [chemical binding]; other site 713604014953 putative active site [active] 713604014954 putative CoA binding site [chemical binding]; other site 713604014955 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604014956 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604014957 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 713604014958 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 713604014959 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 713604014960 putative active site [active] 713604014961 putative metal binding site [ion binding]; other site 713604014962 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604014963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014964 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 713604014965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604014966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014967 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 713604014968 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 713604014969 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 713604014970 Predicted amidohydrolase [General function prediction only]; Region: COG0388 713604014971 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 713604014972 active site 713604014973 catalytic triad [active] 713604014974 dimer interface [polypeptide binding]; other site 713604014975 Right handed beta helix region; Region: Beta_helix; pfam13229 713604014976 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 713604014977 active site 713604014978 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 713604014979 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 713604014980 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604014981 putative ligand binding site [chemical binding]; other site 713604014982 putative NAD binding site [chemical binding]; other site 713604014983 catalytic site [active] 713604014984 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604014985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014986 dimer interface [polypeptide binding]; other site 713604014987 conserved gate region; other site 713604014988 putative PBP binding loops; other site 713604014989 ABC-ATPase subunit interface; other site 713604014990 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 713604014991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604014992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604014993 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 713604014994 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604014995 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604014996 ligand binding site [chemical binding]; other site 713604014997 dimerization interface [polypeptide binding]; other site 713604014998 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604014999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604015000 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 713604015001 Strictosidine synthase; Region: Str_synth; pfam03088 713604015002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604015004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015005 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 713604015006 classical (c) SDRs; Region: SDR_c; cd05233 713604015007 NAD(P) binding site [chemical binding]; other site 713604015008 active site 713604015009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015010 NAD(P) binding site [chemical binding]; other site 713604015011 active site 713604015012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015014 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 713604015015 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604015016 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 713604015017 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 713604015018 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 713604015019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015020 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604015021 putative substrate translocation pore; other site 713604015022 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 713604015023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604015024 DNA-binding site [nucleotide binding]; DNA binding site 713604015025 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604015026 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 713604015027 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 713604015028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604015029 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 713604015030 RHS Repeat; Region: RHS_repeat; cl11982 713604015031 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604015032 RHS Repeat; Region: RHS_repeat; cl11982 713604015033 RHS Repeat; Region: RHS_repeat; pfam05593 713604015034 RHS Repeat; Region: RHS_repeat; pfam05593 713604015035 RHS Repeat; Region: RHS_repeat; pfam05593 713604015036 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604015037 pyranose oxidase; Region: pyranose_ox; TIGR02462 713604015038 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604015039 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 713604015040 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 713604015041 substrate binding site; other site 713604015042 tetramer interface; other site 713604015043 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604015044 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604015045 acyl-activating enzyme (AAE) consensus motif; other site 713604015046 AMP binding site [chemical binding]; other site 713604015047 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604015048 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604015049 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604015050 Condensation domain; Region: Condensation; pfam00668 713604015051 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604015052 Neocarzinostatin family; Region: Neocarzinostat; pfam00960 713604015053 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015054 homodimer interface [polypeptide binding]; other site 713604015055 active site 713604015056 TDP-binding site; other site 713604015057 acceptor substrate-binding pocket; other site 713604015058 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604015059 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 713604015060 O-methyltransferase; Region: Methyltransf_2; pfam00891 713604015061 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 713604015062 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 713604015063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015065 active site 713604015066 phosphorylation site [posttranslational modification] 713604015067 intermolecular recognition site; other site 713604015068 dimerization interface [polypeptide binding]; other site 713604015069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015070 dimerization interface [polypeptide binding]; other site 713604015071 DNA binding residues [nucleotide binding] 713604015072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604015073 Histidine kinase; Region: HisKA_3; pfam07730 713604015074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015075 ATP binding site [chemical binding]; other site 713604015076 G-X-G motif; other site 713604015077 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604015078 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604015079 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604015080 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604015081 Walker A/P-loop; other site 713604015082 ATP binding site [chemical binding]; other site 713604015083 Q-loop/lid; other site 713604015084 ABC transporter signature motif; other site 713604015085 Walker B; other site 713604015086 D-loop; other site 713604015087 H-loop/switch region; other site 713604015088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015089 NAD(P) binding site [chemical binding]; other site 713604015090 active site 713604015091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604015093 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604015094 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604015095 acyl-activating enzyme (AAE) consensus motif; other site 713604015096 AMP binding site [chemical binding]; other site 713604015097 active site 713604015098 CoA binding site [chemical binding]; other site 713604015099 Condensation domain; Region: Condensation; pfam00668 713604015100 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604015101 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015102 homodimer interface [polypeptide binding]; other site 713604015103 active site 713604015104 TDP-binding site; other site 713604015105 acceptor substrate-binding pocket; other site 713604015106 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015107 homodimer interface [polypeptide binding]; other site 713604015108 active site 713604015109 TDP-binding site; other site 713604015110 acceptor substrate-binding pocket; other site 713604015111 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604015112 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015113 homodimer interface [polypeptide binding]; other site 713604015114 active site 713604015115 TDP-binding site; other site 713604015116 acceptor substrate-binding pocket; other site 713604015117 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604015118 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015119 homodimer interface [polypeptide binding]; other site 713604015120 active site 713604015121 TDP-binding site; other site 713604015122 acceptor substrate-binding pocket; other site 713604015123 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604015124 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015125 homodimer interface [polypeptide binding]; other site 713604015126 active site 713604015127 TDP-binding site; other site 713604015128 acceptor substrate-binding pocket; other site 713604015129 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604015130 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604015131 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604015132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604015133 Walker A/P-loop; other site 713604015134 ATP binding site [chemical binding]; other site 713604015135 Q-loop/lid; other site 713604015136 ABC transporter signature motif; other site 713604015137 Walker B; other site 713604015138 D-loop; other site 713604015139 H-loop/switch region; other site 713604015140 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604015141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604015142 S-adenosylmethionine binding site [chemical binding]; other site 713604015143 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604015144 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015145 homodimer interface [polypeptide binding]; other site 713604015146 active site 713604015147 TDP-binding site; other site 713604015148 acceptor substrate-binding pocket; other site 713604015149 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015150 homodimer interface [polypeptide binding]; other site 713604015151 active site 713604015152 TDP-binding site; other site 713604015153 acceptor substrate-binding pocket; other site 713604015154 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 713604015155 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 713604015156 inhibitor-cofactor binding pocket; inhibition site 713604015157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604015158 catalytic residue [active] 713604015159 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604015160 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604015161 AAA ATPase domain; Region: AAA_16; pfam13191 713604015162 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015163 homodimer interface [polypeptide binding]; other site 713604015164 active site 713604015165 TDP-binding site; other site 713604015166 acceptor substrate-binding pocket; other site 713604015167 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 713604015168 hypothetical protein; Provisional; Region: PRK08296 713604015169 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 713604015170 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 713604015171 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604015172 SchA/CurD like domain; Region: SchA_CurD; pfam04486 713604015173 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604015174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015175 NAD(P) binding site [chemical binding]; other site 713604015176 active site 713604015177 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 713604015178 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 713604015179 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 713604015180 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 713604015181 classical (c) SDRs; Region: SDR_c; cd05233 713604015182 NAD(P) binding site [chemical binding]; other site 713604015183 active site 713604015184 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 713604015185 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 713604015186 putative hydrophobic ligand binding site [chemical binding]; other site 713604015187 active site 713604015188 catalytic residues_2 [active] 713604015189 catalytic residues_1 [active] 713604015190 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604015191 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 713604015192 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 713604015193 active site 713604015194 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 713604015195 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 713604015196 dimer interface [polypeptide binding]; other site 713604015197 active site 713604015198 Cupin domain; Region: Cupin_2; pfam07883 713604015199 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 713604015200 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604015201 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604015202 POT family; Region: PTR2; cl17359 713604015203 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 713604015204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604015205 S-adenosylmethionine binding site [chemical binding]; other site 713604015206 hypothetical protein; Provisional; Region: PRK06126 713604015207 hypothetical protein; Provisional; Region: PRK07236 713604015208 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604015209 FAD binding domain; Region: FAD_binding_3; pfam01494 713604015210 hypothetical protein; Provisional; Region: PRK07236 713604015211 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 713604015212 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 713604015213 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 713604015214 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604015215 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604015216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015217 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604015218 NAD(P) binding site [chemical binding]; other site 713604015219 active site 713604015220 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604015221 Cytochrome P450; Region: p450; cl12078 713604015222 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604015223 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604015224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604015225 S-adenosylmethionine binding site [chemical binding]; other site 713604015226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015227 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604015228 NAD(P) binding site [chemical binding]; other site 713604015229 active site 713604015230 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604015231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015232 NAD(P) binding site [chemical binding]; other site 713604015233 active site 713604015234 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604015235 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604015236 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604015237 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604015238 putative sugar binding sites [chemical binding]; other site 713604015239 Q-X-W motif; other site 713604015240 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604015241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604015242 non-specific DNA binding site [nucleotide binding]; other site 713604015243 salt bridge; other site 713604015244 sequence-specific DNA binding site [nucleotide binding]; other site 713604015245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604015246 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604015247 binding surface 713604015248 TPR motif; other site 713604015249 RHS Repeat; Region: RHS_repeat; pfam05593 713604015250 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604015251 RHS Repeat; Region: RHS_repeat; pfam05593 713604015252 RHS Repeat; Region: RHS_repeat; pfam05593 713604015253 RHS Repeat; Region: RHS_repeat; pfam05593 713604015254 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604015255 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 713604015256 dimer interface [polypeptide binding]; other site 713604015257 Short C-terminal domain; Region: SHOCT; pfam09851 713604015258 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 713604015259 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 713604015260 Sulfate transporter family; Region: Sulfate_transp; pfam00916 713604015261 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 713604015262 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015263 Ligand Binding Site [chemical binding]; other site 713604015264 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 713604015265 FMN binding site [chemical binding]; other site 713604015266 dimer interface [polypeptide binding]; other site 713604015267 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 713604015268 dimer interface [polypeptide binding]; other site 713604015269 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015270 Ligand Binding Site [chemical binding]; other site 713604015271 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 713604015272 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 713604015273 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604015274 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 713604015275 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604015276 motif II; other site 713604015277 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 713604015278 Acetokinase family; Region: Acetate_kinase; cl17229 713604015279 propionate/acetate kinase; Provisional; Region: PRK12379 713604015280 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604015281 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604015282 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 713604015283 CoA binding domain; Region: CoA_binding_2; pfam13380 713604015284 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 713604015285 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 713604015286 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604015287 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604015288 Histidine kinase; Region: HisKA_3; pfam07730 713604015289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604015290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015291 ATP binding site [chemical binding]; other site 713604015292 Mg2+ binding site [ion binding]; other site 713604015293 G-X-G motif; other site 713604015294 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 713604015295 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015297 active site 713604015298 phosphorylation site [posttranslational modification] 713604015299 intermolecular recognition site; other site 713604015300 dimerization interface [polypeptide binding]; other site 713604015301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015302 DNA binding residues [nucleotide binding] 713604015303 dimerization interface [polypeptide binding]; other site 713604015304 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 713604015305 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 713604015306 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 713604015307 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 713604015308 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 713604015309 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 713604015310 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 713604015311 Walker A/P-loop; other site 713604015312 ATP binding site [chemical binding]; other site 713604015313 Q-loop/lid; other site 713604015314 ABC transporter signature motif; other site 713604015315 Walker B; other site 713604015316 D-loop; other site 713604015317 H-loop/switch region; other site 713604015318 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 713604015319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604015320 Walker A/P-loop; other site 713604015321 ATP binding site [chemical binding]; other site 713604015322 Q-loop/lid; other site 713604015323 ABC transporter signature motif; other site 713604015324 Walker B; other site 713604015325 D-loop; other site 713604015326 H-loop/switch region; other site 713604015327 putative phosphoketolase; Provisional; Region: PRK05261 713604015328 XFP N-terminal domain; Region: XFP_N; pfam09364 713604015329 Src Homology 3 domain superfamily; Region: SH3; cl17036 713604015330 peptide ligand binding site [polypeptide binding]; other site 713604015331 XFP C-terminal domain; Region: XFP_C; pfam09363 713604015332 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015333 Ligand Binding Site [chemical binding]; other site 713604015334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015335 Ligand Binding Site [chemical binding]; other site 713604015336 FOG: CBS domain [General function prediction only]; Region: COG0517 713604015337 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604015338 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015339 Ligand Binding Site [chemical binding]; other site 713604015340 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015341 Ligand Binding Site [chemical binding]; other site 713604015342 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 713604015343 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604015344 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015345 Ligand Binding Site [chemical binding]; other site 713604015346 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015347 Ligand Binding Site [chemical binding]; other site 713604015348 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604015349 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604015350 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 713604015351 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 713604015352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604015353 Histidine kinase; Region: HisKA_3; pfam07730 713604015354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015355 ATP binding site [chemical binding]; other site 713604015356 Mg2+ binding site [ion binding]; other site 713604015357 G-X-G motif; other site 713604015358 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015360 active site 713604015361 phosphorylation site [posttranslational modification] 713604015362 intermolecular recognition site; other site 713604015363 dimerization interface [polypeptide binding]; other site 713604015364 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015365 DNA binding residues [nucleotide binding] 713604015366 dimerization interface [polypeptide binding]; other site 713604015367 GAF domain; Region: GAF; cl17456 713604015368 ANTAR domain; Region: ANTAR; pfam03861 713604015369 CAAX protease self-immunity; Region: Abi; pfam02517 713604015370 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604015371 Response regulator receiver domain; Region: Response_reg; pfam00072 713604015372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015373 active site 713604015374 phosphorylation site [posttranslational modification] 713604015375 intermolecular recognition site; other site 713604015376 dimerization interface [polypeptide binding]; other site 713604015377 Cupin domain; Region: Cupin_2; pfam07883 713604015378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015380 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604015381 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015382 active site 713604015383 TDP-binding site; other site 713604015384 acceptor substrate-binding pocket; other site 713604015385 MarR family; Region: MarR_2; pfam12802 713604015386 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604015387 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 713604015388 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604015389 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604015390 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 713604015391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604015392 Histidine kinase; Region: HisKA_3; pfam07730 713604015393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015394 ATP binding site [chemical binding]; other site 713604015395 Mg2+ binding site [ion binding]; other site 713604015396 G-X-G motif; other site 713604015397 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015399 active site 713604015400 phosphorylation site [posttranslational modification] 713604015401 intermolecular recognition site; other site 713604015402 dimerization interface [polypeptide binding]; other site 713604015403 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015404 DNA binding residues [nucleotide binding] 713604015405 dimerization interface [polypeptide binding]; other site 713604015406 Right handed beta helix region; Region: Beta_helix; pfam13229 713604015407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604015408 DNA-binding site [nucleotide binding]; DNA binding site 713604015409 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604015410 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 713604015411 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 713604015412 Catalytic site [active] 713604015413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604015415 catalytic core [active] 713604015416 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604015417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604015418 Transposase; Region: HTH_Tnp_1; cl17663 713604015419 putative transposase OrfB; Reviewed; Region: PHA02517 713604015420 HTH-like domain; Region: HTH_21; pfam13276 713604015421 Integrase core domain; Region: rve; pfam00665 713604015422 Integrase core domain; Region: rve_3; pfam13683 713604015423 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 713604015424 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604015425 RHS Repeat; Region: RHS_repeat; pfam05593 713604015426 RHS Repeat; Region: RHS_repeat; pfam05593 713604015427 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604015428 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 713604015429 protein-splicing catalytic site; other site 713604015430 thioester formation/cholesterol transfer; other site 713604015431 Pretoxin HINT domain; Region: PT-HINT; pfam07591 713604015432 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604015433 calcium mediated ligand binding site; other site 713604015434 intermolecular salt bridges; other site 713604015435 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604015436 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604015437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015438 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604015439 Cytochrome P450; Region: p450; cl12078 713604015440 Fructosamine kinase; Region: Fructosamin_kin; cl17579 713604015441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604015442 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604015443 active site 713604015444 metal binding site [ion binding]; metal-binding site 713604015445 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604015446 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604015447 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 713604015448 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604015449 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604015450 metal binding site [ion binding]; metal-binding site 713604015451 active site 713604015452 I-site; other site 713604015453 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604015454 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604015455 putative sugar binding sites [chemical binding]; other site 713604015456 Q-X-W motif; other site 713604015457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015458 active site 713604015459 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 713604015460 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604015461 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 713604015462 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 713604015463 active site 713604015464 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604015465 dimer interface [polypeptide binding]; other site 713604015466 catalytic residues [active] 713604015467 substrate binding site [chemical binding]; other site 713604015468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604015469 Coenzyme A binding pocket [chemical binding]; other site 713604015470 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604015471 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604015472 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604015473 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604015474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604015475 active site 713604015476 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604015477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604015478 active site 713604015479 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604015480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604015481 Walker A/P-loop; other site 713604015482 ATP binding site [chemical binding]; other site 713604015483 Q-loop/lid; other site 713604015484 ABC transporter signature motif; other site 713604015485 Walker B; other site 713604015486 D-loop; other site 713604015487 H-loop/switch region; other site 713604015488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604015489 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604015490 Walker A/P-loop; other site 713604015491 ATP binding site [chemical binding]; other site 713604015492 Q-loop/lid; other site 713604015493 ABC transporter signature motif; other site 713604015494 Walker B; other site 713604015495 D-loop; other site 713604015496 H-loop/switch region; other site 713604015497 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 713604015498 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 713604015499 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604015500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604015501 S-adenosylmethionine binding site [chemical binding]; other site 713604015502 hypothetical protein; Provisional; Region: PRK07236 713604015503 FAD dependent oxidoreductase; Region: DAO; pfam01266 713604015504 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604015505 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604015506 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604015507 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 713604015508 Cytochrome P450; Region: p450; cl12078 713604015509 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604015510 Cytochrome P450; Region: p450; cl12078 713604015511 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 713604015512 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 713604015513 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604015514 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604015515 benzoate transport; Region: 2A0115; TIGR00895 713604015516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015517 putative substrate translocation pore; other site 713604015518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015519 putative substrate translocation pore; other site 713604015520 NB-ARC domain; Region: NB-ARC; pfam00931 713604015521 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604015522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604015523 binding surface 713604015524 TPR motif; other site 713604015525 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604015526 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604015527 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604015528 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 713604015529 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 713604015530 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 713604015531 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 713604015532 active site 713604015533 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 713604015534 MarR family; Region: MarR_2; pfam12802 713604015535 Predicted flavoprotein [General function prediction only]; Region: COG0431 713604015536 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604015537 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 713604015538 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604015539 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604015540 GAF domain; Region: GAF; pfam01590 713604015541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604015542 hypothetical protein; Provisional; Region: PRK07877 713604015543 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015545 active site 713604015546 phosphorylation site [posttranslational modification] 713604015547 intermolecular recognition site; other site 713604015548 dimerization interface [polypeptide binding]; other site 713604015549 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015550 dimerization interface [polypeptide binding]; other site 713604015551 DNA binding residues [nucleotide binding] 713604015552 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 713604015553 BON domain; Region: BON; pfam04972 713604015554 BON domain; Region: BON; pfam04972 713604015555 BON domain; Region: BON; pfam04972 713604015556 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 713604015557 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 713604015558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604015559 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 713604015560 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604015561 GAF domain; Region: GAF_3; pfam13492 713604015562 ANTAR domain; Region: ANTAR; cl04297 713604015563 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604015564 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604015565 Di-iron ligands [ion binding]; other site 713604015566 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 713604015567 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 713604015568 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604015569 anti sigma factor interaction site; other site 713604015570 regulatory phosphorylation site [posttranslational modification]; other site 713604015571 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604015572 XFP C-terminal domain; Region: XFP_C; pfam09363 713604015573 XFP C-terminal domain; Region: XFP_C; pfam09363 713604015574 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 713604015575 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604015576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015577 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604015578 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604015579 putative sugar binding sites [chemical binding]; other site 713604015580 Q-X-W motif; other site 713604015581 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604015582 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604015583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015584 active site 713604015585 phosphorylation site [posttranslational modification] 713604015586 intermolecular recognition site; other site 713604015587 dimerization interface [polypeptide binding]; other site 713604015588 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604015589 DNA binding site [nucleotide binding] 713604015590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604015591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604015592 dimerization interface [polypeptide binding]; other site 713604015593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604015594 dimer interface [polypeptide binding]; other site 713604015595 phosphorylation site [posttranslational modification] 713604015596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015597 ATP binding site [chemical binding]; other site 713604015598 Mg2+ binding site [ion binding]; other site 713604015599 G-X-G motif; other site 713604015600 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604015601 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 713604015602 putative ADP-binding pocket [chemical binding]; other site 713604015603 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604015604 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 713604015605 AAA ATPase domain; Region: AAA_16; pfam13191 713604015606 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 713604015607 short chain dehydrogenase; Provisional; Region: PRK06523 713604015608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015609 NAD(P) binding site [chemical binding]; other site 713604015610 active site 713604015611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015613 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604015614 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604015615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604015616 YCII-related domain; Region: YCII; cl00999 713604015617 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604015618 dimerization interface [polypeptide binding]; other site 713604015619 putative DNA binding site [nucleotide binding]; other site 713604015620 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 713604015621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604015622 motif II; other site 713604015623 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604015624 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604015625 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604015626 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604015627 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604015628 putative sugar binding sites [chemical binding]; other site 713604015629 Q-X-W motif; other site 713604015630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604015631 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604015632 dimerization interface [polypeptide binding]; other site 713604015633 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 713604015634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015635 NAD(P) binding site [chemical binding]; other site 713604015636 active site 713604015637 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 713604015638 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 713604015639 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604015640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015641 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604015642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015643 NAD(P) binding site [chemical binding]; other site 713604015644 active site 713604015645 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604015646 active site 713604015647 substrate binding site [chemical binding]; other site 713604015648 ATP binding site [chemical binding]; other site 713604015649 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604015650 activation loop (A-loop); other site 713604015651 CBD_II domain; Region: CBD_II; smart00637 713604015652 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 713604015653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604015654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604015655 DNA binding residues [nucleotide binding] 713604015656 Leucine carboxyl methyltransferase; Region: LCM; cl01306 713604015657 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604015658 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604015659 Cytochrome P450; Region: p450; cl12078 713604015660 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 713604015661 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604015662 Cytochrome P450; Region: p450; cl12078 713604015663 hypothetical protein; Provisional; Region: PRK06834 713604015664 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604015665 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604015666 MarR family; Region: MarR_2; pfam12802 713604015667 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604015668 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604015669 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604015670 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604015671 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 713604015672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604015673 active site 713604015674 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604015675 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604015676 AAA ATPase domain; Region: AAA_16; pfam13191 713604015677 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015679 DNA binding residues [nucleotide binding] 713604015680 dimerization interface [polypeptide binding]; other site 713604015681 AAA ATPase domain; Region: AAA_16; pfam13191 713604015682 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015683 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015684 DNA binding residues [nucleotide binding] 713604015685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015686 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 713604015687 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 713604015688 putative heme binding pocket [chemical binding]; other site 713604015689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015690 short chain dehydrogenase; Provisional; Region: PRK07041 713604015691 NAD(P) binding site [chemical binding]; other site 713604015692 active site 713604015693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015694 putative substrate translocation pore; other site 713604015695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015698 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015699 dimerization interface [polypeptide binding]; other site 713604015700 DNA binding residues [nucleotide binding] 713604015701 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 713604015702 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 713604015703 putative active site [active] 713604015704 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 713604015705 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 713604015706 Walker A/P-loop; other site 713604015707 ATP binding site [chemical binding]; other site 713604015708 Q-loop/lid; other site 713604015709 ABC transporter signature motif; other site 713604015710 Walker B; other site 713604015711 D-loop; other site 713604015712 H-loop/switch region; other site 713604015713 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 713604015714 active site 713604015715 catalytic site [active] 713604015716 PBP superfamily domain; Region: PBP_like_2; cl17296 713604015717 PBP superfamily domain; Region: PBP_like_2; cl17296 713604015718 PBP superfamily domain; Region: PBP_like_2; cl17296 713604015719 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 713604015720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604015721 dimer interface [polypeptide binding]; other site 713604015722 conserved gate region; other site 713604015723 putative PBP binding loops; other site 713604015724 ABC-ATPase subunit interface; other site 713604015725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604015726 dimer interface [polypeptide binding]; other site 713604015727 conserved gate region; other site 713604015728 putative PBP binding loops; other site 713604015729 ABC-ATPase subunit interface; other site 713604015730 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604015731 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 713604015732 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604015733 dimerization interface [polypeptide binding]; other site 713604015734 ligand binding site [chemical binding]; other site 713604015735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604015736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604015737 dimerization interface [polypeptide binding]; other site 713604015738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604015739 dimer interface [polypeptide binding]; other site 713604015740 phosphorylation site [posttranslational modification] 713604015741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015742 ATP binding site [chemical binding]; other site 713604015743 Mg2+ binding site [ion binding]; other site 713604015744 G-X-G motif; other site 713604015745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604015746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015747 active site 713604015748 phosphorylation site [posttranslational modification] 713604015749 intermolecular recognition site; other site 713604015750 dimerization interface [polypeptide binding]; other site 713604015751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604015752 DNA binding site [nucleotide binding] 713604015753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604015754 active site 713604015755 Predicted membrane protein [Function unknown]; Region: COG2246 713604015756 GtrA-like protein; Region: GtrA; pfam04138 713604015757 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 713604015758 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604015759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604015762 putative substrate translocation pore; other site 713604015763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015764 hypothetical protein; Provisional; Region: PRK07588 713604015765 hypothetical protein; Provisional; Region: PRK07236 713604015766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015768 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604015769 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604015770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015774 DDE superfamily endonuclease; Region: DDE_5; cl17874 713604015775 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604015776 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604015777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015779 WHG domain; Region: WHG; pfam13305 713604015780 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 713604015781 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604015782 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604015783 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604015784 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 713604015785 DDE superfamily endonuclease; Region: DDE_5; cl17874 713604015786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 713604015787 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604015788 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604015789 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604015790 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604015791 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604015792 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 713604015793 catalytic triad [active] 713604015794 conserved cis-peptide bond; other site 713604015795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015796 NAD(P) binding site [chemical binding]; other site 713604015797 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604015798 Uncharacterized conserved protein [Function unknown]; Region: COG1359 713604015799 hypothetical protein; Provisional; Region: PRK08244 713604015800 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604015801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015803 Cupin domain; Region: Cupin_2; pfam07883 713604015804 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604015805 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604015806 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604015807 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604015808 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604015809 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 713604015810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015811 NAD(P) binding site [chemical binding]; other site 713604015812 active site 713604015813 Cupin domain; Region: Cupin_2; pfam07883 713604015814 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604015815 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604015816 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 713604015817 active site 713604015818 metal binding site [ion binding]; metal-binding site 713604015819 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604015820 DNA-binding site [nucleotide binding]; DNA binding site 713604015821 RNA-binding motif; other site 713604015822 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604015823 DNA-binding site [nucleotide binding]; DNA binding site 713604015824 RNA-binding motif; other site 713604015825 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604015826 DNA-binding site [nucleotide binding]; DNA binding site 713604015827 RNA-binding motif; other site 713604015828 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604015829 DNA-binding site [nucleotide binding]; DNA binding site 713604015830 RNA-binding motif; other site 713604015831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015833 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 713604015834 putative hydrophobic ligand binding site [chemical binding]; other site 713604015835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015836 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 713604015837 NAD(P) binding site [chemical binding]; other site 713604015838 active site 713604015839 YCII-related domain; Region: YCII; cl00999 713604015840 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604015841 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604015842 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604015843 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 713604015844 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604015845 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 713604015846 potassium/proton antiporter; Reviewed; Region: PRK05326 713604015847 TrkA-C domain; Region: TrkA_C; pfam02080 713604015848 SPW repeat; Region: SPW; pfam03779 713604015849 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 713604015850 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 713604015851 D-pathway; other site 713604015852 Putative ubiquinol binding site [chemical binding]; other site 713604015853 Low-spin heme (heme b) binding site [chemical binding]; other site 713604015854 Putative water exit pathway; other site 713604015855 Binuclear center (heme o3/CuB) [ion binding]; other site 713604015856 K-pathway; other site 713604015857 Putative proton exit pathway; other site 713604015858 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604015859 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 713604015860 iron-sulfur cluster [ion binding]; other site 713604015861 [2Fe-2S] cluster binding site [ion binding]; other site 713604015862 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 713604015863 heme bH binding site [chemical binding]; other site 713604015864 Qi binding site; other site 713604015865 intrachain domain interface; other site 713604015866 heme bL binding site [chemical binding]; other site 713604015867 interchain domain interface [polypeptide binding]; other site 713604015868 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 713604015869 Qo binding site; other site 713604015870 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 713604015871 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604015872 hypothetical protein; Provisional; Region: PRK07588 713604015873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604015874 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604015875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015877 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604015878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015879 active site 713604015880 phosphorylation site [posttranslational modification] 713604015881 intermolecular recognition site; other site 713604015882 dimerization interface [polypeptide binding]; other site 713604015883 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604015884 DNA binding site [nucleotide binding] 713604015885 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604015886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604015887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604015888 dimer interface [polypeptide binding]; other site 713604015889 phosphorylation site [posttranslational modification] 713604015890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015891 ATP binding site [chemical binding]; other site 713604015892 Mg2+ binding site [ion binding]; other site 713604015893 G-X-G motif; other site 713604015894 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604015895 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604015896 dimerization interface [polypeptide binding]; other site 713604015897 putative DNA binding site [nucleotide binding]; other site 713604015898 putative Zn2+ binding site [ion binding]; other site 713604015899 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 713604015900 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604015901 MarR family; Region: MarR; pfam01047 713604015902 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 713604015903 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 713604015904 Cl- selectivity filter; other site 713604015905 Cl- binding residues [ion binding]; other site 713604015906 pore gating glutamate residue; other site 713604015907 dimer interface [polypeptide binding]; other site 713604015908 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 713604015909 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604015910 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 713604015911 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 713604015912 potential frameshift: common BLAST hit: gi|300787600|ref|YP_003767891.1| formate dehydrogenase alpha subunit, selenocysteine-containing 713604015913 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604015914 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604015915 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604015916 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604015917 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 713604015918 molybdopterin cofactor binding site; other site 713604015919 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 713604015920 4Fe-4S binding domain; Region: Fer4; pfam00037 713604015921 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 713604015922 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 713604015923 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604015924 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604015925 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604015926 active site 713604015927 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 713604015928 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 713604015929 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 713604015930 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 713604015931 transmembrane helices; other site 713604015932 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604015933 potassium/proton antiporter; Reviewed; Region: PRK05326 713604015934 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604015935 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 713604015936 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 713604015937 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 713604015938 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604015939 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 713604015940 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604015941 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 713604015942 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604015943 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604015944 active site 713604015945 catalytic tetrad [active] 713604015946 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 713604015947 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604015948 catalytic Zn binding site [ion binding]; other site 713604015949 NAD(P) binding site [chemical binding]; other site 713604015950 structural Zn binding site [ion binding]; other site 713604015951 short chain dehydrogenase; Provisional; Region: PRK06180 713604015952 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604015953 NADP binding site [chemical binding]; other site 713604015954 active site 713604015955 steroid binding site; other site 713604015956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604015957 salt bridge; other site 713604015958 non-specific DNA binding site [nucleotide binding]; other site 713604015959 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604015960 sequence-specific DNA binding site [nucleotide binding]; other site 713604015961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604015962 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604015963 active site 713604015964 catalytic tetrad [active] 713604015965 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 713604015966 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 713604015967 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604015968 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604015969 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604015970 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604015971 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604015972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604015973 dimer interface [polypeptide binding]; other site 713604015974 conserved gate region; other site 713604015975 putative PBP binding loops; other site 713604015976 ABC-ATPase subunit interface; other site 713604015977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604015978 conserved gate region; other site 713604015979 dimer interface [polypeptide binding]; other site 713604015980 putative PBP binding loops; other site 713604015981 ABC-ATPase subunit interface; other site 713604015982 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604015983 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604015984 DNA binding site [nucleotide binding] 713604015985 domain linker motif; other site 713604015986 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604015987 dimerization interface [polypeptide binding]; other site 713604015988 ligand binding site [chemical binding]; other site 713604015989 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 713604015990 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604015991 dimerization interface [polypeptide binding]; other site 713604015992 ligand binding site [chemical binding]; other site 713604015993 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604015994 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604015995 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 713604015997 DNA binding residues [nucleotide binding] 713604015998 dimerization interface [polypeptide binding]; other site 713604015999 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604016000 DNA binding site [nucleotide binding] 713604016001 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604016002 domain linker motif; other site 713604016003 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604016004 dimerization interface [polypeptide binding]; other site 713604016005 ligand binding site [chemical binding]; other site 713604016006 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 713604016007 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604016008 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604016009 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604016010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604016011 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604016012 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604016013 DDE superfamily endonuclease; Region: DDE_5; cl17874 713604016014 Predicted ATPase [General function prediction only]; Region: COG3903 713604016015 Recombinase; Region: Recombinase; pfam07508 713604016016 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 713604016017 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 713604016018 active site 713604016019 catalytic residues [active] 713604016020 DNA binding site [nucleotide binding] 713604016021 Int/Topo IB signature motif; other site 713604016022 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 713604016023 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 713604016024 ligand binding site [chemical binding]; other site 713604016025 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604016026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604016027 TPR motif; other site 713604016028 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 713604016029 active site 713604016030 iron coordination sites [ion binding]; other site 713604016031 substrate binding pocket [chemical binding]; other site 713604016032 CHAT domain; Region: CHAT; cl17868 713604016033 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604016034 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 713604016035 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 713604016036 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 713604016037 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 713604016038 DDE superfamily endonuclease; Region: DDE_5; cl17874 713604016039 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604016040 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604016041 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 713604016042 Restriction endonuclease; Region: Mrr_cat; pfam04471 713604016043 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 713604016044 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 713604016045 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 713604016046 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 713604016047 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 713604016048 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 713604016049 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 713604016050 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 713604016051 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 713604016052 putative transposase OrfB; Reviewed; Region: PHA02517 713604016053 HTH-like domain; Region: HTH_21; pfam13276 713604016054 Integrase core domain; Region: rve; pfam00665 713604016055 Integrase core domain; Region: rve_3; pfam13683 713604016056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604016057 Transposase; Region: HTH_Tnp_1; cl17663 713604016058 Integrase core domain; Region: rve; pfam00665 713604016059 Integrase core domain; Region: rve_3; pfam13683 713604016060 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 713604016061 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604016062 DDE superfamily endonuclease; Region: DDE_4; cl17710 713604016063 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604016064 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 713604016065 structural tetrad; other site 713604016066 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604016067 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 713604016068 structural tetrad; other site 713604016069 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 713604016070 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 713604016071 catalytic residues [active] 713604016072 catalytic nucleophile [active] 713604016073 Recombinase; Region: Recombinase; pfam07508 713604016074 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 713604016075 Cellulose binding domain; Region: CBM_2; pfam00553 713604016076 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 713604016077 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 713604016078 putative dimer interface [polypeptide binding]; other site 713604016079 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604016080 amidase; Provisional; Region: PRK06170 713604016081 Amidase; Region: Amidase; cl11426 713604016082 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 713604016083 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604016084 DNA binding residues [nucleotide binding] 713604016085 drug binding residues [chemical binding]; other site 713604016086 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 713604016087 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604016088 dimerization interface [polypeptide binding]; other site 713604016089 putative DNA binding site [nucleotide binding]; other site 713604016090 putative Zn2+ binding site [ion binding]; other site 713604016091 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 713604016092 Cation efflux family; Region: Cation_efflux; cl00316 713604016093 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 713604016094 Leucine-rich repeats; other site 713604016095 Substrate binding site [chemical binding]; other site 713604016096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604016097 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604016098 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 713604016099 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604016100 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604016101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604016102 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604016103 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604016104 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604016105 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604016106 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604016107 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 713604016108 metal ion-dependent adhesion site (MIDAS); other site 713604016109 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 713604016110 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604016111 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604016112 active site 713604016113 ATP binding site [chemical binding]; other site 713604016114 substrate binding site [chemical binding]; other site 713604016115 activation loop (A-loop); other site 713604016116 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604016117 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 713604016118 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604016119 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604016120 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604016121 Walker A/P-loop; other site 713604016122 ATP binding site [chemical binding]; other site 713604016123 Q-loop/lid; other site 713604016124 ABC transporter signature motif; other site 713604016125 Walker B; other site 713604016126 D-loop; other site 713604016127 H-loop/switch region; other site 713604016128 Predicted transcriptional regulators [Transcription]; Region: COG1725 713604016129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604016130 DNA-binding site [nucleotide binding]; DNA binding site 713604016131 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 713604016132 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 713604016133 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604016134 dimer interface [polypeptide binding]; other site 713604016135 PYR/PP interface [polypeptide binding]; other site 713604016136 TPP binding site [chemical binding]; other site 713604016137 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604016138 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 713604016139 TPP-binding site [chemical binding]; other site 713604016140 Domain of unknown function (DUF222); Region: DUF222; pfam02720 713604016141 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604016142 active site 713604016143 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604016144 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604016145 putative DNA binding site [nucleotide binding]; other site 713604016146 putative Zn2+ binding site [ion binding]; other site 713604016147 AsnC family; Region: AsnC_trans_reg; pfam01037 713604016148 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 713604016149 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 713604016150 dimer interface [polypeptide binding]; other site 713604016151 PYR/PP interface [polypeptide binding]; other site 713604016152 TPP binding site [chemical binding]; other site 713604016153 substrate binding site [chemical binding]; other site 713604016154 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 713604016155 TPP-binding site; other site 713604016156 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 713604016157 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604016158 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 713604016159 DNA binding residues [nucleotide binding] 713604016160 dimerization interface [polypeptide binding]; other site 713604016161 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 713604016162 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604016163 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 713604016164 CAAX protease self-immunity; Region: Abi; cl00558 713604016165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604016166 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604016167 NAD(P) binding site [chemical binding]; other site 713604016168 active site 713604016169 EamA-like transporter family; Region: EamA; pfam00892 713604016170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604016171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604016172 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604016173 putative dimerization interface [polypeptide binding]; other site 713604016174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604016175 threonine dehydratase; Provisional; Region: PRK08246 713604016176 hypothetical protein; Provisional; Region: PRK06815 713604016177 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604016178 catalytic residue [active] 713604016179 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604016180 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604016181 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604016182 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604016183 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604016184 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 713604016185 transcription termination factor Rho; Provisional; Region: PRK12608 713604016186 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 713604016187 RNA binding site [nucleotide binding]; other site 713604016188 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604016189 Walker A motif; other site 713604016190 ATP binding site [chemical binding]; other site 713604016191 Walker B motif; other site 713604016192 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604016193 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 713604016194 Mg2+ binding site [ion binding]; other site 713604016195 G-X-G motif; other site 713604016196 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 713604016197 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604016198 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604016199 Cellulose binding domain; Region: CBM_2; cl17741 713604016200 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604016201 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604016202 salt bridge; other site 713604016203 non-specific DNA binding site [nucleotide binding]; other site 713604016204 sequence-specific DNA binding site [nucleotide binding]; other site 713604016205 short chain dehydrogenase; Provisional; Region: PRK06180 713604016206 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604016207 NADP binding site [chemical binding]; other site 713604016208 active site 713604016209 steroid binding site; other site 713604016210 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604016211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604016212 NAD(P) binding site [chemical binding]; other site 713604016213 active site 713604016214 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 713604016215 putative substrate binding site [chemical binding]; other site 713604016216 putative ATP binding site [chemical binding]; other site 713604016217 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604016218 catalytic core [active] 713604016219 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604016220 GAF domain; Region: GAF; pfam01590 713604016221 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604016222 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604016223 anti sigma factor interaction site; other site 713604016224 regulatory phosphorylation site [posttranslational modification]; other site 713604016225 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604016226 anti sigma factor interaction site; other site 713604016227 regulatory phosphorylation site [posttranslational modification]; other site 713604016228 GAF domain; Region: GAF; pfam01590 713604016229 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604016230 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 713604016231 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604016232 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604016233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604016234 Mg2+ binding site [ion binding]; other site 713604016235 PAS fold; Region: PAS_4; pfam08448 713604016236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604016237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604016238 dimer interface [polypeptide binding]; other site 713604016239 phosphorylation site [posttranslational modification] 713604016240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604016241 ATP binding site [chemical binding]; other site 713604016242 Mg2+ binding site [ion binding]; other site 713604016243 G-X-G motif; other site 713604016244 Response regulator receiver domain; Region: Response_reg; pfam00072 713604016245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604016246 active site 713604016247 phosphorylation site [posttranslational modification] 713604016248 intermolecular recognition site; other site 713604016249 dimerization interface [polypeptide binding]; other site 713604016250 PAS domain; Region: PAS_9; pfam13426 713604016251 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604016252 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604016253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604016254 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604016255 anti sigma factor interaction site; other site 713604016256 regulatory phosphorylation site [posttranslational modification]; other site 713604016257 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604016258 GAF domain; Region: GAF; pfam01590 713604016259 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 713604016260 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604016261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604016262 ATP binding site [chemical binding]; other site 713604016263 Mg2+ binding site [ion binding]; other site 713604016264 G-X-G motif; other site 713604016265 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 713604016266 Domain interface; other site 713604016267 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 713604016268 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604016269 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 713604016270 putative ligand binding site [chemical binding]; other site 713604016271 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604016272 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604016273 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604016274 active site 713604016275 catalytic tetrad [active] 713604016276 short chain dehydrogenase; Provisional; Region: PRK05854 713604016277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604016278 NAD(P) binding site [chemical binding]; other site 713604016279 active site 713604016280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604016281 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604016282 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604016283 DNA binding site [nucleotide binding] 713604016284 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604016285 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604016286 AAA domain; Region: AAA_22; pfam13401 713604016287 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604016288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604016289 TPR motif; other site 713604016290 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604016291 binding surface 713604016292 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604016293 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604016294 non-specific DNA binding site [nucleotide binding]; other site 713604016295 salt bridge; other site 713604016296 sequence-specific DNA binding site [nucleotide binding]; other site 713604016297 Flavoprotein; Region: Flavoprotein; pfam02441 713604016298 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604016299 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604016300 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 713604016301 active site 713604016302 catalytic residues [active] 713604016303 DNA binding site [nucleotide binding] 713604016304 Int/Topo IB signature motif; other site 713604016305 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 713604016306 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 713604016307 NAD(P) binding site [chemical binding]; other site 713604016308 catalytic residues [active] 713604016309 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604016310 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 713604016311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604016312 non-specific DNA binding site [nucleotide binding]; other site 713604016313 salt bridge; other site 713604016314 sequence-specific DNA binding site [nucleotide binding]; other site 713604016315 Biofilm formation and stress response factor; Region: BsmA; cl01794 713604016316 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604016317 anti sigma factor interaction site; other site 713604016318 regulatory phosphorylation site [posttranslational modification]; other site 713604016319 methionine sulfoxide reductase A; Provisional; Region: PRK14054 713604016320 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 713604016321 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 713604016322 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 713604016323 active site 713604016324 Zn binding site [ion binding]; other site 713604016325 OsmC-like protein; Region: OsmC; pfam02566 713604016326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604016327 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604016328 Walker A/P-loop; other site 713604016329 ATP binding site [chemical binding]; other site 713604016330 Q-loop/lid; other site 713604016331 ABC transporter signature motif; other site 713604016332 Walker B; other site 713604016333 D-loop; other site 713604016334 H-loop/switch region; other site 713604016335 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604016336 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604016337 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604016338 oxidoreductase; Provisional; Region: PRK06196 713604016339 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 713604016340 putative NAD(P) binding site [chemical binding]; other site 713604016341 active site 713604016342 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604016343 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604016344 active site 713604016345 ATP binding site [chemical binding]; other site 713604016346 substrate binding site [chemical binding]; other site 713604016347 activation loop (A-loop); other site 713604016348 YCII-related domain; Region: YCII; cl00999 713604016349 NAD-dependent deacetylase; Provisional; Region: PRK00481 713604016350 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 713604016351 NAD+ binding site [chemical binding]; other site 713604016352 substrate binding site [chemical binding]; other site 713604016353 Zn binding site [ion binding]; other site 713604016354 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 713604016355 ApbE family; Region: ApbE; pfam02424 713604016356 ApbE family; Region: ApbE; pfam02424 713604016357 Phosphoesterase family; Region: Phosphoesterase; pfam04185 713604016358 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604016359 Tannase and feruloyl esterase; Region: Tannase; pfam07519 713604016360 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 713604016361 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604016362 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 713604016363 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 713604016364 YcaO-like family; Region: YcaO; pfam02624 713604016365 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604016366 GAF domain; Region: GAF; pfam01590 713604016367 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604016368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604016369 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604016370 putative substrate translocation pore; other site 713604016371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604016372 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 713604016373 NAD(P) binding site [chemical binding]; other site 713604016374 active site 713604016375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604016376 sequence-specific DNA binding site [nucleotide binding]; other site 713604016377 salt bridge; other site 713604016378 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604016379 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604016380 active site 713604016381 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604016382 HTH domain; Region: HTH_11; pfam08279 713604016383 WYL domain; Region: WYL; pfam13280 713604016384 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604016385 hydrophobic ligand binding site; other site 713604016386 acyl-CoA synthetase; Validated; Region: PRK07788 713604016387 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604016388 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604016389 acyl-activating enzyme (AAE) consensus motif; other site 713604016390 acyl-activating enzyme (AAE) consensus motif; other site 713604016391 AMP binding site [chemical binding]; other site 713604016392 active site 713604016393 CoA binding site [chemical binding]; other site 713604016394 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 713604016395 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604016396 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604016397 MoxR-like ATPases [General function prediction only]; Region: COG0714 713604016398 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 713604016399 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 713604016400 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604016401 metal ion-dependent adhesion site (MIDAS); other site 713604016402 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 713604016403 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604016404 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604016405 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604016406 SCP-2 sterol transfer family; Region: SCP2; pfam02036 713604016407 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604016408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604016409 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 713604016410 substrate binding site [chemical binding]; other site 713604016411 catalytic residues [active] 713604016412 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 713604016413 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 713604016414 dimer interface [polypeptide binding]; other site 713604016415 NADP binding site [chemical binding]; other site 713604016416 catalytic residues [active] 713604016417 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 713604016418 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 713604016419 active site 713604016420 tetramer interface [polypeptide binding]; other site 713604016421 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 713604016422 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 713604016423 catalytic residue [active] 713604016424 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 713604016425 Na binding site [ion binding]; other site 713604016426 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604016427 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604016428 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604016429 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604016430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604016431 NAD(P) binding site [chemical binding]; other site 713604016432 active site 713604016433 Clp amino terminal domain; Region: Clp_N; pfam02861 713604016434 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 713604016435 DNA-binding interface [nucleotide binding]; DNA binding site 713604016436 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604016437 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 713604016438 NodB motif; other site 713604016439 putative active site [active] 713604016440 putative catalytic site [active] 713604016441 putative Zn binding site [ion binding]; other site 713604016442 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604016443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604016444 active site 713604016445 phosphorylation site [posttranslational modification] 713604016446 intermolecular recognition site; other site 713604016447 dimerization interface [polypeptide binding]; other site 713604016448 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604016449 DNA binding residues [nucleotide binding] 713604016450 dimerization interface [polypeptide binding]; other site 713604016451 Phosphotransferase enzyme family; Region: APH; pfam01636 713604016452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604016453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604016454 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604016455 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 713604016456 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 713604016457 FMN-binding pocket [chemical binding]; other site 713604016458 flavin binding motif; other site 713604016459 phosphate binding motif [ion binding]; other site 713604016460 beta-alpha-beta structure motif; other site 713604016461 NAD binding pocket [chemical binding]; other site 713604016462 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604016463 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 713604016464 catalytic loop [active] 713604016465 iron binding site [ion binding]; other site 713604016466 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 713604016467 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 713604016468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604016469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604016470 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 713604016471 active site 713604016472 dimer interface [polypeptide binding]; other site 713604016473 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 713604016474 metal binding site [ion binding]; metal-binding site 713604016475 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 713604016476 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 713604016477 active site 713604016478 FAD binding domain; Region: FAD_binding_3; pfam01494 713604016479 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604016480 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 713604016481 active site 713604016482 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 713604016483 Zn binding site [ion binding]; other site 713604016484 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604016485 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604016486 acyl-activating enzyme (AAE) consensus motif; other site 713604016487 AMP binding site [chemical binding]; other site 713604016488 active site 713604016489 CoA binding site [chemical binding]; other site 713604016490 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604016491 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 713604016492 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604016493 putative trimer interface [polypeptide binding]; other site 713604016494 putative CoA binding site [chemical binding]; other site 713604016495 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604016496 putative trimer interface [polypeptide binding]; other site 713604016497 putative CoA binding site [chemical binding]; other site 713604016498 GTP-binding protein Der; Reviewed; Region: PRK03003 713604016499 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 713604016500 G1 box; other site 713604016501 GTP/Mg2+ binding site [chemical binding]; other site 713604016502 Switch I region; other site 713604016503 G2 box; other site 713604016504 Switch II region; other site 713604016505 G3 box; other site 713604016506 G4 box; other site 713604016507 G5 box; other site 713604016508 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 713604016509 G1 box; other site 713604016510 GTP/Mg2+ binding site [chemical binding]; other site 713604016511 Switch I region; other site 713604016512 G2 box; other site 713604016513 G3 box; other site 713604016514 Switch II region; other site 713604016515 G4 box; other site 713604016516 G5 box; other site 713604016517 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604016518 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604016519 putative acyl-acceptor binding pocket; other site 713604016520 cytidylate kinase; Provisional; Region: cmk; PRK00023 713604016521 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 713604016522 CMP-binding site; other site 713604016523 The sites determining sugar specificity; other site 713604016524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604016525 WHG domain; Region: WHG; pfam13305 713604016526 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 713604016527 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 713604016528 TrkA-C domain; Region: TrkA_C; pfam02080 713604016529 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 713604016530 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 713604016531 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 713604016532 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604016533 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 713604016534 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 713604016535 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713604016536 RNA binding surface [nucleotide binding]; other site 713604016537 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 713604016538 active site 713604016539 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 713604016540 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 713604016541 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 713604016542 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604016543 P-loop; other site 713604016544 Magnesium ion binding site [ion binding]; other site 713604016545 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604016546 Magnesium ion binding site [ion binding]; other site 713604016547 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 713604016548 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604016549 active site 713604016550 DNA binding site [nucleotide binding] 713604016551 Int/Topo IB signature motif; other site 713604016552 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604016553 TM2 domain; Region: TM2; pfam05154 713604016554 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 713604016555 dimer interface [polypeptide binding]; other site 713604016556 ADP-ribose binding site [chemical binding]; other site 713604016557 active site 713604016558 nudix motif; other site 713604016559 metal binding site [ion binding]; metal-binding site 713604016560 CTP synthetase; Validated; Region: pyrG; PRK05380 713604016561 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 713604016562 active site 713604016563 UTP binding site [chemical binding]; other site 713604016564 Catalytic site [active] 713604016565 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 713604016566 active site 713604016567 putative oxyanion hole; other site 713604016568 catalytic triad [active] 713604016569 Acyltransferase family; Region: Acyl_transf_3; pfam01757 713604016570 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604016571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604016572 DNA-binding site [nucleotide binding]; DNA binding site 713604016573 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604016574 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 713604016575 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 713604016576 Na binding site [ion binding]; other site 713604016577 putative substrate binding site [chemical binding]; other site 713604016578 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 713604016579 Alginate lyase; Region: Alginate_lyase; pfam05426 713604016580 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 713604016581 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 713604016582 Thiamine pyrophosphokinase; Region: TPK; cl08415 713604016583 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 713604016584 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 713604016585 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 713604016586 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604016587 putative NAD(P) binding site [chemical binding]; other site 713604016588 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604016589 MarR family; Region: MarR_2; pfam12802 713604016590 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 713604016591 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 713604016592 Walker A/P-loop; other site 713604016593 ATP binding site [chemical binding]; other site 713604016594 Q-loop/lid; other site 713604016595 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 713604016596 ABC transporter signature motif; other site 713604016597 Walker B; other site 713604016598 D-loop; other site 713604016599 H-loop/switch region; other site 713604016600 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 713604016601 ATP-NAD kinase; Region: NAD_kinase; pfam01513 713604016602 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 713604016603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713604016604 RNA binding surface [nucleotide binding]; other site 713604016605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604016606 S-adenosylmethionine binding site [chemical binding]; other site 713604016607 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 713604016608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604016609 active site 713604016610 motif I; other site 713604016611 motif II; other site 713604016612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604016613 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 713604016614 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 713604016615 active site 713604016616 HIGH motif; other site 713604016617 dimer interface [polypeptide binding]; other site 713604016618 KMSKS motif; other site 713604016619 S4 RNA-binding domain; Region: S4; smart00363 713604016620 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 713604016621 active site 713604016622 DNA binding site [nucleotide binding] 713604016623 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 713604016624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 713604016625 argininosuccinate lyase; Provisional; Region: PRK00855 713604016626 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 713604016627 active sites [active] 713604016628 tetramer interface [polypeptide binding]; other site 713604016629 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 713604016630 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 713604016631 arginine repressor; Provisional; Region: PRK03341 713604016632 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 713604016633 ornithine carbamoyltransferase; Provisional; Region: PRK00779 713604016634 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 713604016635 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 713604016636 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 713604016637 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604016638 inhibitor-cofactor binding pocket; inhibition site 713604016639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604016640 catalytic residue [active] 713604016641 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 713604016642 feedback inhibition sensing region; other site 713604016643 homohexameric interface [polypeptide binding]; other site 713604016644 nucleotide binding site [chemical binding]; other site 713604016645 N-acetyl-L-glutamate binding site [chemical binding]; other site 713604016646 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 713604016647 heterotetramer interface [polypeptide binding]; other site 713604016648 active site pocket [active] 713604016649 cleavage site 713604016650 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 713604016651 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 713604016652 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604016653 HTH domain; Region: HTH_11; pfam08279 713604016654 WYL domain; Region: WYL; pfam13280 713604016655 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604016656 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604016657 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 713604016658 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 713604016659 active site 713604016660 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 713604016661 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 713604016662 putative tRNA-binding site [nucleotide binding]; other site 713604016663 B3/4 domain; Region: B3_4; pfam03483 713604016664 tRNA synthetase B5 domain; Region: B5; smart00874 713604016665 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 713604016666 dimer interface [polypeptide binding]; other site 713604016667 motif 1; other site 713604016668 motif 3; other site 713604016669 motif 2; other site 713604016670 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 713604016671 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 713604016672 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 713604016673 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 713604016674 dimer interface [polypeptide binding]; other site 713604016675 motif 1; other site 713604016676 active site 713604016677 motif 2; other site 713604016678 motif 3; other site 713604016679 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 713604016680 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 713604016681 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 713604016682 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 713604016683 23S rRNA binding site [nucleotide binding]; other site 713604016684 L21 binding site [polypeptide binding]; other site 713604016685 L13 binding site [polypeptide binding]; other site 713604016686 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 713604016687 translation initiation factor IF-3; Region: infC; TIGR00168 713604016688 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 713604016689 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 713604016690 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604016691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604016692 DNA-binding site [nucleotide binding]; DNA binding site 713604016693 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 713604016694 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 713604016695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604016696 catalytic residue [active] 713604016697 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 713604016698 homotrimer interaction site [polypeptide binding]; other site 713604016699 putative active site [active] 713604016700 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604016701 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 713604016702 DNA binding site [nucleotide binding] 713604016703 sequence specific DNA binding site [nucleotide binding]; other site 713604016704 putative cAMP binding site [chemical binding]; other site 713604016705 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604016706 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 713604016707 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604016708 substrate binding site [chemical binding]; other site 713604016709 ATP binding site [chemical binding]; other site 713604016710 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 713604016711 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 713604016712 active site 713604016713 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604016714 dimer interface [polypeptide binding]; other site 713604016715 substrate binding site [chemical binding]; other site 713604016716 catalytic residue [active] 713604016717 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 713604016718 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 713604016719 active site 713604016720 putative substrate binding pocket [chemical binding]; other site 713604016721 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604016722 fructuronate transporter; Provisional; Region: PRK10034; cl15264 713604016723 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 713604016724 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604016725 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604016726 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 713604016727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604016728 dimer interface [polypeptide binding]; other site 713604016729 conserved gate region; other site 713604016730 putative PBP binding loops; other site 713604016731 ABC-ATPase subunit interface; other site 713604016732 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604016733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604016734 dimer interface [polypeptide binding]; other site 713604016735 conserved gate region; other site 713604016736 putative PBP binding loops; other site 713604016737 ABC-ATPase subunit interface; other site 713604016738 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 713604016739 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 713604016740 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 713604016741 active site 713604016742 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 713604016743 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 713604016744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604016745 active site 713604016746 phosphorylation site [posttranslational modification] 713604016747 intermolecular recognition site; other site 713604016748 dimerization interface [polypeptide binding]; other site 713604016749 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 713604016750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 713604016751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604016752 ATP binding site [chemical binding]; other site 713604016753 Mg2+ binding site [ion binding]; other site 713604016754 G-X-G motif; other site 713604016755 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 713604016756 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 713604016757 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604016758 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604016759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604016760 putative substrate translocation pore; other site 713604016761 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604016762 hydrophobic ligand binding site; other site 713604016763 Putative zinc-finger; Region: zf-HC2; pfam13490 713604016764 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604016765 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604016766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604016767 DNA binding residues [nucleotide binding] 713604016768 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604016769 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604016770 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 713604016771 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 713604016772 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 713604016773 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 713604016774 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 713604016775 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 713604016776 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 713604016777 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 713604016778 active site 713604016779 Family description; Region: UvrD_C_2; pfam13538 713604016780 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 713604016781 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604016782 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604016783 ligand binding site [chemical binding]; other site 713604016784 flexible hinge region; other site 713604016785 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 713604016786 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 713604016787 RNA/DNA hybrid binding site [nucleotide binding]; other site 713604016788 active site 713604016789 hypothetical protein; Provisional; Region: PRK04233 713604016790 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604016791 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604016792 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 713604016793 Ca binding site [ion binding]; other site 713604016794 Ca binding site (active) [ion binding]; other site 713604016795 ligand binding site [chemical binding]; other site 713604016796 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 713604016797 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604016798 substrate binding pocket [chemical binding]; other site 713604016799 catalytic triad [active] 713604016800 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 713604016801 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 713604016802 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 713604016803 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604016804 catalytic core [active] 713604016805 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 713604016806 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 713604016807 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604016808 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604016809 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604016810 DNA binding site [nucleotide binding] 713604016811 domain linker motif; other site 713604016812 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604016813 dimerization interface [polypeptide binding]; other site 713604016814 ligand binding site [chemical binding]; other site 713604016815 Helix-turn-helix domain; Region: HTH_17; cl17695 713604016816 RES domain; Region: RES; pfam08808 713604016817 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 713604016818 YCII-related domain; Region: YCII; cl00999 713604016819 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 713604016820 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604016821 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 713604016822 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604016823 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604016824 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604016825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604016826 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 713604016827 Walker A/P-loop; other site 713604016828 ATP binding site [chemical binding]; other site 713604016829 Q-loop/lid; other site 713604016830 ABC transporter signature motif; other site 713604016831 Walker B; other site 713604016832 D-loop; other site 713604016833 H-loop/switch region; other site 713604016834 Transposase; Region: DEDD_Tnp_IS110; pfam01548 713604016835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 713604016836 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 713604016837 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 713604016838 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604016839 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604016840 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604016841 substrate binding site [chemical binding]; other site 713604016842 oxyanion hole (OAH) forming residues; other site 713604016843 trimer interface [polypeptide binding]; other site 713604016844 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604016845 hydrophobic ligand binding site; other site 713604016846 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 713604016847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604016848 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604016849 excinuclease ABC subunit B; Provisional; Region: PRK05298 713604016850 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604016851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604016852 nucleotide binding region [chemical binding]; other site 713604016853 ATP-binding site [chemical binding]; other site 713604016854 Ultra-violet resistance protein B; Region: UvrB; pfam12344 713604016855 UvrB/uvrC motif; Region: UVR; pfam02151 713604016856 Protein of unknown function (DUF402); Region: DUF402; cl00979 713604016857 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 713604016858 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 713604016859 CoA-binding site [chemical binding]; other site 713604016860 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 713604016861 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 713604016862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604016863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604016864 WHG domain; Region: WHG; pfam13305 713604016865 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 713604016866 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 713604016867 RNA binding site [nucleotide binding]; other site 713604016868 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 713604016869 RNA binding site [nucleotide binding]; other site 713604016870 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 713604016871 RNA binding site [nucleotide binding]; other site 713604016872 S1 RNA binding domain; Region: S1; pfam00575 713604016873 RNA binding site [nucleotide binding]; other site 713604016874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604016875 S-adenosylmethionine binding site [chemical binding]; other site 713604016876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604016877 Coenzyme A binding pocket [chemical binding]; other site 713604016878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604016879 Walker A/P-loop; other site 713604016880 ATP binding site [chemical binding]; other site 713604016881 Q-loop/lid; other site 713604016882 ABC transporter signature motif; other site 713604016883 Walker B; other site 713604016884 H-loop/switch region; other site 713604016885 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 713604016886 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 713604016887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604016888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604016889 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 713604016890 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 713604016891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604016892 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604016893 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604016894 putative NAD(P) binding site [chemical binding]; other site 713604016895 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604016896 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 713604016897 EF-hand domain pair; Region: EF_hand_5; pfam13499 713604016898 Ca2+ binding site [ion binding]; other site 713604016899 DNA polymerase I; Provisional; Region: PRK05755 713604016900 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 713604016901 active site 713604016902 metal binding site 1 [ion binding]; metal-binding site 713604016903 putative 5' ssDNA interaction site; other site 713604016904 metal binding site 3; metal-binding site 713604016905 metal binding site 2 [ion binding]; metal-binding site 713604016906 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 713604016907 putative DNA binding site [nucleotide binding]; other site 713604016908 putative metal binding site [ion binding]; other site 713604016909 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 713604016910 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 713604016911 active site 713604016912 DNA binding site [nucleotide binding] 713604016913 catalytic site [active] 713604016914 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604016915 CoenzymeA binding site [chemical binding]; other site 713604016916 subunit interaction site [polypeptide binding]; other site 713604016917 PHB binding site; other site 713604016918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604016919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604016920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604016921 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604016922 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 713604016923 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 713604016924 dimerization interface [polypeptide binding]; other site 713604016925 ligand binding site [chemical binding]; other site 713604016926 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 713604016927 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604016928 TM-ABC transporter signature motif; other site 713604016929 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 713604016930 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 713604016931 TM-ABC transporter signature motif; other site 713604016932 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604016933 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 713604016934 Walker A/P-loop; other site 713604016935 ATP binding site [chemical binding]; other site 713604016936 Q-loop/lid; other site 713604016937 ABC transporter signature motif; other site 713604016938 Walker B; other site 713604016939 D-loop; other site 713604016940 H-loop/switch region; other site 713604016941 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 713604016942 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 713604016943 Walker A/P-loop; other site 713604016944 ATP binding site [chemical binding]; other site 713604016945 Q-loop/lid; other site 713604016946 ABC transporter signature motif; other site 713604016947 Walker B; other site 713604016948 D-loop; other site 713604016949 H-loop/switch region; other site 713604016950 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 713604016951 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 713604016952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604016953 active site 713604016954 phosphorylation site [posttranslational modification] 713604016955 intermolecular recognition site; other site 713604016956 dimerization interface [polypeptide binding]; other site 713604016957 ANTAR domain; Region: ANTAR; pfam03861 713604016958 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 713604016959 active site 713604016960 catalytic residues [active] 713604016961 DNA binding site [nucleotide binding] 713604016962 Int/Topo IB signature motif; other site 713604016963 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604016964 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 713604016965 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 713604016966 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 713604016967 cofactor binding site; other site 713604016968 DNA binding site [nucleotide binding] 713604016969 substrate interaction site [chemical binding]; other site 713604016970 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 713604016971 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 713604016972 Ligand Binding Site [chemical binding]; other site 713604016973 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 713604016974 polymerase nucleotide-binding site; other site 713604016975 DNA-binding residues [nucleotide binding]; DNA binding site 713604016976 nucleotide binding site [chemical binding]; other site 713604016977 primase nucleotide-binding site [nucleotide binding]; other site 713604016978 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 713604016979 dimer interface [polypeptide binding]; other site 713604016980 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 713604016981 ssDNA binding site [nucleotide binding]; other site 713604016982 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604016983 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604016984 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 713604016985 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 713604016986 nudix motif; other site 713604016987 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604016988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604016989 DNA-binding site [nucleotide binding]; DNA binding site 713604016990 Phosphotransferase enzyme family; Region: APH; pfam01636 713604016991 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604016992 active site 713604016993 ATP binding site [chemical binding]; other site 713604016994 substrate binding site [chemical binding]; other site 713604016995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604016996 Coenzyme A binding pocket [chemical binding]; other site 713604016997 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 713604016998 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 713604016999 nucleotide binding site/active site [active] 713604017000 HIT family signature motif; other site 713604017001 catalytic residue [active] 713604017002 AAA ATPase domain; Region: AAA_16; pfam13191 713604017003 potential frameshift: common BLAST hit: gi|300787997|ref|YP_003768288.1| integrase 713604017004 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604017005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017007 DNA binding residues [nucleotide binding] 713604017008 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604017009 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 713604017010 EspG family; Region: ESX-1_EspG; pfam14011 713604017011 Histidine kinase; Region: HisKA_3; pfam07730 713604017012 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604017013 ATP binding site [chemical binding]; other site 713604017014 Mg2+ binding site [ion binding]; other site 713604017015 G-X-G motif; other site 713604017016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604017018 active site 713604017019 phosphorylation site [posttranslational modification] 713604017020 intermolecular recognition site; other site 713604017021 dimerization interface [polypeptide binding]; other site 713604017022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017023 DNA binding residues [nucleotide binding] 713604017024 dimerization interface [polypeptide binding]; other site 713604017025 RDD family; Region: RDD; pfam06271 713604017026 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604017027 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604017028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604017030 active site 713604017031 phosphorylation site [posttranslational modification] 713604017032 intermolecular recognition site; other site 713604017033 dimerization interface [polypeptide binding]; other site 713604017034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017035 DNA binding residues [nucleotide binding] 713604017036 dimerization interface [polypeptide binding]; other site 713604017037 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604017038 Histidine kinase; Region: HisKA_3; pfam07730 713604017039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604017040 ATP binding site [chemical binding]; other site 713604017041 Mg2+ binding site [ion binding]; other site 713604017042 G-X-G motif; other site 713604017043 CHAT domain; Region: CHAT; cl17868 713604017044 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604017045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017046 NAD(P) binding site [chemical binding]; other site 713604017047 active site 713604017048 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 713604017049 Q-loop/lid; other site 713604017050 ABC transporter signature motif; other site 713604017051 Walker B; other site 713604017052 D-loop; other site 713604017053 H-loop/switch region; other site 713604017054 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 713604017055 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604017056 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017057 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017058 DNA binding residues [nucleotide binding] 713604017059 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 713604017060 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 713604017061 active site 713604017062 NAD binding site [chemical binding]; other site 713604017063 metal binding site [ion binding]; metal-binding site 713604017064 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 713604017065 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604017066 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604017067 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604017068 NAD(P) binding site [chemical binding]; other site 713604017069 catalytic residues [active] 713604017070 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 713604017071 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604017072 active site pocket [active] 713604017073 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 713604017074 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604017075 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 713604017076 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604017077 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604017078 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604017079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604017080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604017081 non-specific DNA binding site [nucleotide binding]; other site 713604017082 salt bridge; other site 713604017083 sequence-specific DNA binding site [nucleotide binding]; other site 713604017084 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 713604017085 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604017086 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604017087 conserved cys residue [active] 713604017088 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604017089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604017090 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604017091 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604017092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 713604017093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017094 short chain dehydrogenase; Provisional; Region: PRK06197 713604017095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017096 NAD(P) binding site [chemical binding]; other site 713604017097 active site 713604017098 Helix-turn-helix domain; Region: HTH_31; pfam13560 713604017099 ANTAR domain; Region: ANTAR; pfam03861 713604017100 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 713604017101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017102 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604017103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017104 DNA binding residues [nucleotide binding] 713604017105 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604017106 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604017107 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 713604017108 Peptidase family M28; Region: Peptidase_M28; pfam04389 713604017109 metal binding site [ion binding]; metal-binding site 713604017110 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 713604017111 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 713604017112 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604017113 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 713604017114 dimer interface [polypeptide binding]; other site 713604017115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604017116 catalytic residue [active] 713604017117 Condensation domain; Region: Condensation; pfam00668 713604017118 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017119 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604017120 Condensation domain; Region: Condensation; pfam00668 713604017121 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017122 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604017123 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604017124 Condensation domain; Region: Condensation; pfam00668 713604017125 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017126 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604017127 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604017128 active site 713604017129 AMP binding site [chemical binding]; other site 713604017130 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604017131 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604017132 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604017133 acyl-activating enzyme (AAE) consensus motif; other site 713604017134 AMP binding site [chemical binding]; other site 713604017135 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604017136 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604017137 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604017138 acyl-activating enzyme (AAE) consensus motif; other site 713604017139 AMP binding site [chemical binding]; other site 713604017140 Condensation domain; Region: Condensation; pfam00668 713604017141 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017142 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604017143 MbtH-like protein; Region: MbtH; cl01279 713604017144 acyl-CoA synthetase; Validated; Region: PRK05850 713604017145 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604017146 acyl-activating enzyme (AAE) consensus motif; other site 713604017147 active site 713604017148 Condensation domain; Region: Condensation; pfam00668 713604017149 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017150 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604017151 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604017152 acyl-activating enzyme (AAE) consensus motif; other site 713604017153 AMP binding site [chemical binding]; other site 713604017154 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604017155 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604017156 Cytochrome P450; Region: p450; cl12078 713604017157 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 713604017158 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604017159 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604017160 acyl-activating enzyme (AAE) consensus motif; other site 713604017161 AMP binding site [chemical binding]; other site 713604017162 Thioesterase domain; Region: Thioesterase; pfam00975 713604017163 Condensation domain; Region: Condensation; pfam00668 713604017164 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017165 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604017166 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604017167 acyl-activating enzyme (AAE) consensus motif; other site 713604017168 AMP binding site [chemical binding]; other site 713604017169 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604017170 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604017171 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604017172 acyl-activating enzyme (AAE) consensus motif; other site 713604017173 AMP binding site [chemical binding]; other site 713604017174 active site 713604017175 CoA binding site [chemical binding]; other site 713604017176 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604017177 AAA ATPase domain; Region: AAA_16; pfam13191 713604017178 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017179 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017180 DNA binding residues [nucleotide binding] 713604017181 dimerization interface [polypeptide binding]; other site 713604017182 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 713604017183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604017184 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604017185 dimerization interface [polypeptide binding]; other site 713604017186 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 713604017187 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604017188 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604017189 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604017190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604017191 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604017192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017193 NAD(P) binding site [chemical binding]; other site 713604017194 active site 713604017195 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 713604017196 Cell division protein FtsQ; Region: FtsQ; pfam03799 713604017197 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 713604017198 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 713604017199 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713604017200 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713604017201 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 713604017202 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 713604017203 homodimer interface [polypeptide binding]; other site 713604017204 active site 713604017205 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 713604017206 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 713604017207 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 713604017208 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713604017209 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713604017210 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 713604017211 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 713604017212 Mg++ binding site [ion binding]; other site 713604017213 putative catalytic motif [active] 713604017214 putative substrate binding site [chemical binding]; other site 713604017215 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 713604017216 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 713604017217 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713604017218 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713604017219 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 713604017220 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 713604017221 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713604017222 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713604017223 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 713604017224 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 713604017225 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 713604017226 MraW methylase family; Region: Methyltransf_5; pfam01795 713604017227 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 713604017228 cell division protein MraZ; Reviewed; Region: PRK00326 713604017229 MraZ protein; Region: MraZ; pfam02381 713604017230 MraZ protein; Region: MraZ; pfam02381 713604017231 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604017232 EspG family; Region: ESX-1_EspG; pfam14011 713604017233 MoxR-like ATPases [General function prediction only]; Region: COG0714 713604017234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604017235 ATP binding site [chemical binding]; other site 713604017236 Walker A motif; other site 713604017237 Walker B motif; other site 713604017238 arginine finger; other site 713604017239 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 713604017240 Protein of unknown function DUF58; Region: DUF58; pfam01882 713604017241 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 713604017242 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 713604017243 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 713604017244 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 713604017245 active site 713604017246 DNA polymerase IV; Validated; Region: PRK02406 713604017247 DNA binding site [nucleotide binding] 713604017248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604017249 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604017250 S-adenosylmethionine binding site [chemical binding]; other site 713604017251 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 713604017252 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604017253 P-loop; other site 713604017254 Magnesium ion binding site [ion binding]; other site 713604017255 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604017256 Magnesium ion binding site [ion binding]; other site 713604017257 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 713604017258 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 713604017259 putative DNA binding site [nucleotide binding]; other site 713604017260 catalytic residue [active] 713604017261 putative H2TH interface [polypeptide binding]; other site 713604017262 putative catalytic residues [active] 713604017263 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604017264 adenosine deaminase; Provisional; Region: PRK09358 713604017265 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 713604017266 active site 713604017267 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604017268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604017269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604017270 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 713604017271 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 713604017272 quinone interaction residues [chemical binding]; other site 713604017273 active site 713604017274 catalytic residues [active] 713604017275 FMN binding site [chemical binding]; other site 713604017276 substrate binding site [chemical binding]; other site 713604017277 Amidase; Region: Amidase; cl11426 713604017278 allophanate hydrolase; Provisional; Region: PRK08186 713604017279 CobD/Cbib protein; Region: CobD_Cbib; cl00561 713604017280 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 713604017281 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604017282 non-specific DNA binding site [nucleotide binding]; other site 713604017283 salt bridge; other site 713604017284 sequence-specific DNA binding site [nucleotide binding]; other site 713604017285 Competence-damaged protein; Region: CinA; pfam02464 713604017286 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 713604017287 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 713604017288 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 713604017289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604017290 FeS/SAM binding site; other site 713604017291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604017292 Coenzyme A binding pocket [chemical binding]; other site 713604017293 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 713604017294 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 713604017295 FMN binding site [chemical binding]; other site 713604017296 dimer interface [polypeptide binding]; other site 713604017297 RloB-like protein; Region: RloB; pfam13707 713604017298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604017299 AAA domain; Region: AAA_21; pfam13304 713604017300 Walker A/P-loop; other site 713604017301 ATP binding site [chemical binding]; other site 713604017302 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 713604017303 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604017304 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 713604017305 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604017306 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604017307 putative acyl-acceptor binding pocket; other site 713604017308 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 713604017309 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604017310 EamA-like transporter family; Region: EamA; pfam00892 713604017311 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 713604017312 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604017313 metal ion-dependent adhesion site (MIDAS); other site 713604017314 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 713604017315 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604017316 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 713604017317 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 713604017318 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 713604017319 dimer interface [polypeptide binding]; other site 713604017320 active site 713604017321 catalytic residue [active] 713604017322 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604017323 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604017324 active site 713604017325 ATP binding site [chemical binding]; other site 713604017326 substrate binding site [chemical binding]; other site 713604017327 activation loop (A-loop); other site 713604017328 Septum formation; Region: Septum_form; pfam13845 713604017329 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 713604017330 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 713604017331 Uncharacterized conserved protein [Function unknown]; Region: COG3603 713604017332 Family description; Region: ACT_7; pfam13840 713604017333 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 713604017334 HicB family; Region: HicB; pfam05534 713604017335 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604017336 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604017337 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604017338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 713604017339 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604017340 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604017341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604017342 sequence-specific DNA binding site [nucleotide binding]; other site 713604017343 salt bridge; other site 713604017344 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604017345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604017346 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604017347 dimerization interface [polypeptide binding]; other site 713604017348 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 713604017349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604017350 dihydrodipicolinate reductase; Provisional; Region: PRK00048 713604017351 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 713604017352 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 713604017353 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 713604017354 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 713604017355 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 713604017356 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 713604017357 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 713604017358 oligomer interface [polypeptide binding]; other site 713604017359 RNA binding site [nucleotide binding]; other site 713604017360 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 713604017361 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 713604017362 RNase E interface [polypeptide binding]; other site 713604017363 trimer interface [polypeptide binding]; other site 713604017364 active site 713604017365 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 713604017366 putative nucleic acid binding region [nucleotide binding]; other site 713604017367 G-X-X-G motif; other site 713604017368 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 713604017369 RNA binding site [nucleotide binding]; other site 713604017370 domain interface; other site 713604017371 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 713604017372 16S/18S rRNA binding site [nucleotide binding]; other site 713604017373 S13e-L30e interaction site [polypeptide binding]; other site 713604017374 25S rRNA binding site [nucleotide binding]; other site 713604017375 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 713604017376 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 713604017377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604017378 non-specific DNA binding site [nucleotide binding]; other site 713604017379 salt bridge; other site 713604017380 sequence-specific DNA binding site [nucleotide binding]; other site 713604017381 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 713604017382 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 713604017383 active site 713604017384 Riboflavin kinase; Region: Flavokinase; smart00904 713604017385 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 713604017386 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 713604017387 RNA binding site [nucleotide binding]; other site 713604017388 active site 713604017389 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 713604017390 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604017391 active site 713604017392 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604017393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604017394 putative substrate translocation pore; other site 713604017395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604017396 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 713604017397 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 713604017398 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 713604017399 DHH family; Region: DHH; pfam01368 713604017400 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 713604017401 Methyltransferase domain; Region: Methyltransf_26; pfam13659 713604017402 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 713604017403 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 713604017404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604017407 S-adenosylmethionine binding site [chemical binding]; other site 713604017408 Putative esterase; Region: Esterase; pfam00756 713604017409 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 713604017410 Protein of unknown function (DUF503); Region: DUF503; pfam04456 713604017411 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 713604017412 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 713604017413 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 713604017414 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 713604017415 G1 box; other site 713604017416 putative GEF interaction site [polypeptide binding]; other site 713604017417 GTP/Mg2+ binding site [chemical binding]; other site 713604017418 Switch I region; other site 713604017419 G2 box; other site 713604017420 G3 box; other site 713604017421 Switch II region; other site 713604017422 G4 box; other site 713604017423 G5 box; other site 713604017424 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 713604017425 Translation-initiation factor 2; Region: IF-2; pfam11987 713604017426 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 713604017427 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 713604017428 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 713604017429 NusA N-terminal domain; Region: NusA_N; pfam08529 713604017430 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 713604017431 RNA binding site [nucleotide binding]; other site 713604017432 homodimer interface [polypeptide binding]; other site 713604017433 NusA-like KH domain; Region: KH_5; pfam13184 713604017434 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 713604017435 G-X-X-G motif; other site 713604017436 ribosome maturation protein RimP; Reviewed; Region: PRK00092 713604017437 Sm and related proteins; Region: Sm_like; cl00259 713604017438 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 713604017439 putative oligomer interface [polypeptide binding]; other site 713604017440 putative RNA binding site [nucleotide binding]; other site 713604017441 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 713604017442 dinuclear metal binding motif [ion binding]; other site 713604017443 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604017444 catalytic residue [active] 713604017445 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 713604017446 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 713604017447 oligomerization interface [polypeptide binding]; other site 713604017448 active site 713604017449 metal binding site [ion binding]; metal-binding site 713604017450 Predicted membrane protein [Function unknown]; Region: COG3428 713604017451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017452 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 713604017453 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604017454 Histidine kinase; Region: HisKA_3; pfam07730 713604017455 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604017456 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604017458 active site 713604017459 phosphorylation site [posttranslational modification] 713604017460 intermolecular recognition site; other site 713604017461 dimerization interface [polypeptide binding]; other site 713604017462 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017463 DNA binding residues [nucleotide binding] 713604017464 dimerization interface [polypeptide binding]; other site 713604017465 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 713604017466 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 713604017467 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604017468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604017469 dimerization interface [polypeptide binding]; other site 713604017470 putative DNA binding site [nucleotide binding]; other site 713604017471 putative Zn2+ binding site [ion binding]; other site 713604017472 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 713604017473 putative hydrophobic ligand binding site [chemical binding]; other site 713604017474 protein interface [polypeptide binding]; other site 713604017475 gate; other site 713604017476 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604017477 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 713604017478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604017479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604017480 active site 713604017481 phosphorylation site [posttranslational modification] 713604017482 intermolecular recognition site; other site 713604017483 dimerization interface [polypeptide binding]; other site 713604017484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604017485 DNA binding site [nucleotide binding] 713604017486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604017487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604017488 dimer interface [polypeptide binding]; other site 713604017489 phosphorylation site [posttranslational modification] 713604017490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604017491 ATP binding site [chemical binding]; other site 713604017492 Mg2+ binding site [ion binding]; other site 713604017493 G-X-G motif; other site 713604017494 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017496 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 713604017497 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604017498 AAA domain; Region: AAA_22; pfam13401 713604017499 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017500 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604017502 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 713604017503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604017504 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604017505 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604017506 enoyl-CoA hydratase; Provisional; Region: PRK08252 713604017507 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604017508 substrate binding site [chemical binding]; other site 713604017509 oxyanion hole (OAH) forming residues; other site 713604017510 trimer interface [polypeptide binding]; other site 713604017511 acetoacetate decarboxylase; Provisional; Region: PRK02265 713604017512 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 713604017513 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604017514 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604017515 acyl-coenzyme A oxidase; Region: PLN02526 713604017516 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604017517 active site 713604017518 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604017519 short chain dehydrogenase; Provisional; Region: PRK07024 713604017520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017521 NAD(P) binding site [chemical binding]; other site 713604017522 active site 713604017523 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604017524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017526 DNA binding residues [nucleotide binding] 713604017527 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604017528 Transcription factor WhiB; Region: Whib; pfam02467 713604017529 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604017530 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604017531 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604017532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017534 DNA binding residues [nucleotide binding] 713604017535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604017536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604017537 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604017538 dimerization interface [polypeptide binding]; other site 713604017539 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 713604017540 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 713604017541 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 713604017542 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 713604017543 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 713604017544 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 713604017545 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604017546 Cytochrome P450; Region: p450; cl12078 713604017547 Winged helix-turn helix; Region: HTH_29; pfam13551 713604017548 Homeodomain-like domain; Region: HTH_32; pfam13565 713604017549 DDE superfamily endonuclease; Region: DDE_3; pfam13358 713604017550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017551 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604017552 NAD(P) binding site [chemical binding]; other site 713604017553 active site 713604017554 RibD C-terminal domain; Region: RibD_C; cl17279 713604017555 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604017556 dimerization interface [polypeptide binding]; other site 713604017557 putative DNA binding site [nucleotide binding]; other site 713604017558 putative Zn2+ binding site [ion binding]; other site 713604017559 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 713604017560 putative hydrophobic ligand binding site [chemical binding]; other site 713604017561 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604017562 DNA binding site [nucleotide binding] 713604017563 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604017564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604017565 binding surface 713604017566 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017567 TPR motif; other site 713604017568 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017569 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 713604017570 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 713604017571 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 713604017572 kynureninase; Region: kynureninase; TIGR01814 713604017573 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604017574 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604017575 catalytic residue [active] 713604017576 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604017577 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 713604017578 haloalkane dehalogenase; Provisional; Region: PRK03592 713604017579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017581 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 713604017582 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604017583 Di-iron ligands [ion binding]; other site 713604017584 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 713604017585 Rubredoxin; Region: Rubredoxin; pfam00301 713604017586 iron binding site [ion binding]; other site 713604017587 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604017588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604017589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604017590 ATP binding site [chemical binding]; other site 713604017591 Mg2+ binding site [ion binding]; other site 713604017592 G-X-G motif; other site 713604017593 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604017594 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604017595 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604017596 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604017597 G2 box; other site 713604017598 Switch I region; other site 713604017599 G3 box; other site 713604017600 Switch II region; other site 713604017601 GTP/Mg2+ binding site [chemical binding]; other site 713604017602 G4 box; other site 713604017603 G5 box; other site 713604017604 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 713604017605 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 713604017606 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017607 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604017608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017610 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 713604017611 Cupin domain; Region: Cupin_2; cl17218 713604017612 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604017613 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604017614 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 713604017615 inhibitor binding site; inhibition site 713604017616 active site 713604017617 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604017618 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604017619 YCII-related domain; Region: YCII; cl00999 713604017620 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604017621 PGAP1-like protein; Region: PGAP1; pfam07819 713604017622 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604017623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017625 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604017626 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604017627 putative NAD(P) binding site [chemical binding]; other site 713604017628 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604017629 AAA ATPase domain; Region: AAA_16; pfam13191 713604017630 Caspase domain; Region: Peptidase_C14; pfam00656 713604017631 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 713604017632 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 713604017633 nucleotide binding site [chemical binding]; other site 713604017634 putative NEF/HSP70 interaction site [polypeptide binding]; other site 713604017635 SBD interface [polypeptide binding]; other site 713604017636 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604017637 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604017638 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604017639 active site 713604017640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017641 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 713604017642 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604017643 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604017644 putative sugar binding sites [chemical binding]; other site 713604017645 Q-X-W motif; other site 713604017646 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604017647 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604017648 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604017649 putative sugar binding sites [chemical binding]; other site 713604017650 Q-X-W motif; other site 713604017651 DEAD-like helicases superfamily; Region: DEXDc; smart00487 713604017652 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604017653 Family description; Region: UvrD_C_2; pfam13538 713604017654 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604017655 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017656 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017657 DNA binding residues [nucleotide binding] 713604017658 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604017659 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604017660 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604017661 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 713604017662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017664 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017665 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017666 DNA binding residues [nucleotide binding] 713604017667 dimerization interface [polypeptide binding]; other site 713604017668 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 713604017669 polypeptide substrate binding site [polypeptide binding]; other site 713604017670 active site 713604017671 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604017672 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 713604017673 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604017674 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604017675 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604017676 active site 713604017677 catalytic triad [active] 713604017678 oxyanion hole [active] 713604017679 Phosphotransferase enzyme family; Region: APH; pfam01636 713604017680 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 713604017681 active site 713604017682 ATP binding site [chemical binding]; other site 713604017683 substrate binding site [chemical binding]; other site 713604017684 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 713604017685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017686 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604017687 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604017688 active site 713604017689 TDP-binding site; other site 713604017690 acceptor substrate-binding pocket; other site 713604017691 homodimer interface [polypeptide binding]; other site 713604017692 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604017693 DNA binding site [nucleotide binding] 713604017694 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604017695 AAA ATPase domain; Region: AAA_16; pfam13191 713604017696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604017697 TPR motif; other site 713604017698 binding surface 713604017699 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604017701 binding surface 713604017702 TPR motif; other site 713604017703 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604017704 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 713604017705 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604017706 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604017707 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604017708 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604017709 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604017710 active site 713604017711 catalytic tetrad [active] 713604017712 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604017713 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 713604017714 AAA ATPase domain; Region: AAA_16; pfam13191 713604017715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017716 DNA binding residues [nucleotide binding] 713604017717 dimerization interface [polypeptide binding]; other site 713604017718 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604017719 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 713604017720 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604017721 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604017722 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604017723 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604017724 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604017725 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604017726 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 713604017727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017728 dimerization interface [polypeptide binding]; other site 713604017729 DNA binding residues [nucleotide binding] 713604017730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604017731 acyl-coenzyme A oxidase; Region: PLN02526 713604017732 active site 713604017733 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 713604017734 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 713604017735 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 713604017736 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604017737 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 713604017738 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 713604017739 acyl-activating enzyme (AAE) consensus motif; other site 713604017740 putative AMP binding site [chemical binding]; other site 713604017741 putative active site [active] 713604017742 putative CoA binding site [chemical binding]; other site 713604017743 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604017744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017745 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604017746 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604017747 AAA ATPase domain; Region: AAA_16; pfam13191 713604017748 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017749 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017750 DNA binding residues [nucleotide binding] 713604017751 dimerization interface [polypeptide binding]; other site 713604017752 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017753 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017754 DNA binding residues [nucleotide binding] 713604017755 dimerization interface [polypeptide binding]; other site 713604017756 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604017757 Predicted acyl esterases [General function prediction only]; Region: COG2936 713604017758 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604017759 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 713604017760 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 713604017761 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604017762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604017763 putative substrate translocation pore; other site 713604017764 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 713604017765 putative ligand binding site [chemical binding]; other site 713604017766 putative catalytic site [active] 713604017767 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 713604017768 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 713604017769 sugar binding site [chemical binding]; other site 713604017770 Muconolactone delta-isomerase; Region: MIase; cl01992 713604017771 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604017772 anti sigma factor interaction site; other site 713604017773 regulatory phosphorylation site [posttranslational modification]; other site 713604017774 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 713604017775 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 713604017776 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604017777 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604017778 ATP binding site [chemical binding]; other site 713604017779 Mg2+ binding site [ion binding]; other site 713604017780 G-X-G motif; other site 713604017781 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604017782 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 713604017783 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604017784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604017785 Walker A/P-loop; other site 713604017786 ATP binding site [chemical binding]; other site 713604017787 Q-loop/lid; other site 713604017788 ABC transporter signature motif; other site 713604017789 Walker B; other site 713604017790 D-loop; other site 713604017791 H-loop/switch region; other site 713604017792 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604017793 Histidine kinase; Region: HisKA_3; pfam07730 713604017794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604017795 ATP binding site [chemical binding]; other site 713604017796 Mg2+ binding site [ion binding]; other site 713604017797 G-X-G motif; other site 713604017798 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604017800 active site 713604017801 phosphorylation site [posttranslational modification] 713604017802 intermolecular recognition site; other site 713604017803 dimerization interface [polypeptide binding]; other site 713604017804 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017805 DNA binding residues [nucleotide binding] 713604017806 dimerization interface [polypeptide binding]; other site 713604017807 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604017808 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604017809 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 713604017810 Penicillinase repressor; Region: Pencillinase_R; pfam03965 713604017811 Peptidase family M48; Region: Peptidase_M48; cl12018 713604017812 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 713604017813 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 713604017814 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604017815 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 713604017816 Walker A/P-loop; other site 713604017817 ATP binding site [chemical binding]; other site 713604017818 Q-loop/lid; other site 713604017819 ABC transporter signature motif; other site 713604017820 Walker B; other site 713604017821 D-loop; other site 713604017822 H-loop/switch region; other site 713604017823 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604017824 Histidine kinase; Region: HisKA_3; pfam07730 713604017825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604017826 ATP binding site [chemical binding]; other site 713604017827 Mg2+ binding site [ion binding]; other site 713604017828 G-X-G motif; other site 713604017829 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604017831 active site 713604017832 phosphorylation site [posttranslational modification] 713604017833 intermolecular recognition site; other site 713604017834 dimerization interface [polypeptide binding]; other site 713604017835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017836 dimerization interface [polypeptide binding]; other site 713604017837 DNA binding residues [nucleotide binding] 713604017838 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604017839 CheB methylesterase; Region: CheB_methylest; pfam01339 713604017840 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017841 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017842 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604017843 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 713604017844 NADP binding site [chemical binding]; other site 713604017845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017846 NAD(P) binding site [chemical binding]; other site 713604017847 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604017848 active site 713604017849 Cupin domain; Region: Cupin_2; pfam07883 713604017850 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 713604017851 DJ-1 family protein; Region: not_thiJ; TIGR01383 713604017852 conserved cys residue [active] 713604017853 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604017854 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604017855 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604017856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604017857 putative substrate translocation pore; other site 713604017858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604017859 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 713604017860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017861 NAD(P) binding site [chemical binding]; other site 713604017862 active site 713604017863 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604017864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017865 NAD(P) binding site [chemical binding]; other site 713604017866 active site 713604017867 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 713604017868 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604017869 MarR family; Region: MarR_2; pfam12802 713604017870 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604017871 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604017872 conserved cys residue [active] 713604017873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604017874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604017875 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604017876 Zn2+ binding site [ion binding]; other site 713604017877 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 713604017878 Mg2+ binding site [ion binding]; other site 713604017879 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 713604017880 homotrimer interaction site [polypeptide binding]; other site 713604017881 putative active site [active] 713604017882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017883 GAF domain; Region: GAF; pfam01590 713604017884 ANTAR domain; Region: ANTAR; pfam03861 713604017885 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 713604017886 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604017887 metal-binding site [ion binding] 713604017888 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604017889 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604017890 metal-binding site [ion binding] 713604017891 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 713604017892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017893 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017894 DNA binding residues [nucleotide binding] 713604017895 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604017896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017898 DNA binding residues [nucleotide binding] 713604017899 Putative zinc-finger; Region: zf-HC2; pfam13490 713604017900 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 713604017901 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 713604017902 DJ-1 family protein; Region: not_thiJ; TIGR01383 713604017903 conserved cys residue [active] 713604017904 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 713604017905 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 713604017906 Walker A/P-loop; other site 713604017907 ATP binding site [chemical binding]; other site 713604017908 Q-loop/lid; other site 713604017909 ABC transporter signature motif; other site 713604017910 Walker B; other site 713604017911 D-loop; other site 713604017912 H-loop/switch region; other site 713604017913 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 713604017914 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 713604017915 putative PBP binding regions; other site 713604017916 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 713604017917 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 713604017918 intersubunit interface [polypeptide binding]; other site 713604017919 CopC domain; Region: CopC; pfam04234 713604017920 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 713604017921 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604017922 metal-binding site [ion binding] 713604017923 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604017924 Soluble P-type ATPase [General function prediction only]; Region: COG4087 713604017925 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 713604017926 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 713604017927 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 713604017928 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 713604017929 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 713604017930 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604017931 anti sigma factor interaction site; other site 713604017932 regulatory phosphorylation site [posttranslational modification]; other site 713604017933 ANTAR domain; Region: ANTAR; pfam03861 713604017934 GAF domain; Region: GAF; pfam01590 713604017935 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 713604017936 ANTAR domain; Region: ANTAR; pfam03861 713604017937 ANTAR domain; Region: ANTAR; pfam03861 713604017938 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 713604017939 GAF domain; Region: GAF; pfam01590 713604017940 GAF domain; Region: GAF_2; pfam13185 713604017941 ANTAR domain; Region: ANTAR; pfam03861 713604017942 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604017943 OsmC-like protein; Region: OsmC; cl00767 713604017944 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604017945 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 713604017946 molybdopterin cofactor binding site; other site 713604017947 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 713604017948 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 713604017949 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 713604017950 NAD binding site [chemical binding]; other site 713604017951 catalytic Zn binding site [ion binding]; other site 713604017952 structural Zn binding site [ion binding]; other site 713604017953 ANTAR domain; Region: ANTAR; pfam03861 713604017954 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 713604017955 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 713604017956 putative NAD(P) binding site [chemical binding]; other site 713604017957 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604017958 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 713604017959 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 713604017960 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604017961 NAD(P) binding site [chemical binding]; other site 713604017962 catalytic residues [active] 713604017963 Predicted membrane protein [Function unknown]; Region: COG4129 713604017964 thiamine pyrophosphate protein; Provisional; Region: PRK08273 713604017965 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 713604017966 PYR/PP interface [polypeptide binding]; other site 713604017967 dimer interface [polypeptide binding]; other site 713604017968 tetramer interface [polypeptide binding]; other site 713604017969 TPP binding site [chemical binding]; other site 713604017970 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604017971 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 713604017972 TPP-binding site [chemical binding]; other site 713604017973 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 713604017974 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604017975 putative active site pocket [active] 713604017976 putative metal binding site [ion binding]; other site 713604017977 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604017978 FAD binding domain; Region: FAD_binding_4; pfam01565 713604017979 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 713604017980 ChaB; Region: ChaB; pfam06150 713604017981 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 713604017982 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 713604017983 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 713604017984 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604017985 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 713604017986 XFP N-terminal domain; Region: XFP_N; pfam09364 713604017987 putative phosphoketolase; Provisional; Region: PRK05261 713604017988 XFP C-terminal domain; Region: XFP_C; pfam09363 713604017989 Hemerythrin-like domain; Region: Hr-like; cd12108 713604017990 Fe binding site [ion binding]; other site 713604017991 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 713604017992 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 713604017993 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604017994 NAD binding site [chemical binding]; other site 713604017995 catalytic Zn binding site [ion binding]; other site 713604017996 structural Zn binding site [ion binding]; other site 713604017997 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 713604017998 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 713604017999 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 713604018000 transmembrane helices; other site 713604018001 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604018002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604018003 Walker A/P-loop; other site 713604018004 ATP binding site [chemical binding]; other site 713604018005 Q-loop/lid; other site 713604018006 ABC transporter signature motif; other site 713604018007 Walker B; other site 713604018008 D-loop; other site 713604018009 H-loop/switch region; other site 713604018010 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 713604018011 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604018012 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 713604018013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604018014 S-adenosylmethionine binding site [chemical binding]; other site 713604018015 DNA primase; Validated; Region: dnaG; PRK05667 713604018016 CHC2 zinc finger; Region: zf-CHC2; pfam01807 713604018017 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 713604018018 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 713604018019 active site 713604018020 metal binding site [ion binding]; metal-binding site 713604018021 interdomain interaction site; other site 713604018022 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 713604018023 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 713604018024 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604018025 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604018026 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604018027 DNA binding residues [nucleotide binding] 713604018028 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604018029 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604018030 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604018031 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604018032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604018033 MarR family; Region: MarR_2; pfam12802 713604018034 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604018035 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604018036 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 713604018037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018038 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604018039 DinB superfamily; Region: DinB_2; pfam12867 713604018040 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 713604018041 serpin-like protein; Provisional; Region: PHA02660 713604018042 reactive center loop; other site 713604018043 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 713604018044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604018045 Zn2+ binding site [ion binding]; other site 713604018046 Mg2+ binding site [ion binding]; other site 713604018047 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 713604018048 Uncharacterized conserved protein [Function unknown]; Region: COG1434 713604018049 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 713604018050 putative active site [active] 713604018051 Response regulator receiver domain; Region: Response_reg; pfam00072 713604018052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018053 active site 713604018054 phosphorylation site [posttranslational modification] 713604018055 intermolecular recognition site; other site 713604018056 dimerization interface [polypeptide binding]; other site 713604018057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604018058 DNA binding residues [nucleotide binding] 713604018059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604018060 Histidine kinase; Region: HisKA_3; pfam07730 713604018061 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604018062 ATP binding site [chemical binding]; other site 713604018063 Mg2+ binding site [ion binding]; other site 713604018064 G-X-G motif; other site 713604018065 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604018066 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604018067 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604018068 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604018069 Walker A/P-loop; other site 713604018070 ATP binding site [chemical binding]; other site 713604018071 Q-loop/lid; other site 713604018072 ABC transporter signature motif; other site 713604018073 Walker B; other site 713604018074 D-loop; other site 713604018075 H-loop/switch region; other site 713604018076 glycyl-tRNA synthetase; Provisional; Region: PRK04173 713604018077 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604018078 motif 1; other site 713604018079 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 713604018080 motif 1; other site 713604018081 dimer interface [polypeptide binding]; other site 713604018082 active site 713604018083 motif 2; other site 713604018084 motif 3; other site 713604018085 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 713604018086 anticodon binding site; other site 713604018087 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604018088 active site 713604018089 putative catalytic site [active] 713604018090 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 713604018091 active site 713604018092 catalytic site [active] 713604018093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604018094 dimerization interface [polypeptide binding]; other site 713604018095 putative DNA binding site [nucleotide binding]; other site 713604018096 putative Zn2+ binding site [ion binding]; other site 713604018097 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 713604018098 metal binding site 2 [ion binding]; metal-binding site 713604018099 putative DNA binding helix; other site 713604018100 metal binding site 1 [ion binding]; metal-binding site 713604018101 dimer interface [polypeptide binding]; other site 713604018102 structural Zn2+ binding site [ion binding]; other site 713604018103 TIGR03943 family protein; Region: TIGR03943 713604018104 Predicted permease; Region: DUF318; cl17795 713604018105 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 713604018106 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 713604018107 catalytic residue [active] 713604018108 putative FPP diphosphate binding site; other site 713604018109 putative FPP binding hydrophobic cleft; other site 713604018110 dimer interface [polypeptide binding]; other site 713604018111 putative IPP diphosphate binding site; other site 713604018112 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 713604018113 Recombination protein O N terminal; Region: RecO_N; pfam11967 713604018114 Recombination protein O C terminal; Region: RecO_C; pfam02565 713604018115 Interferon-induced transmembrane protein; Region: CD225; pfam04505 713604018116 RDD family; Region: RDD; pfam06271 713604018117 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 713604018118 Interferon-induced transmembrane protein; Region: CD225; pfam04505 713604018119 Interferon-induced transmembrane protein; Region: CD225; pfam04505 713604018120 GTPase Era; Reviewed; Region: era; PRK00089 713604018121 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 713604018122 G1 box; other site 713604018123 GTP/Mg2+ binding site [chemical binding]; other site 713604018124 Switch I region; other site 713604018125 G2 box; other site 713604018126 Switch II region; other site 713604018127 G3 box; other site 713604018128 G4 box; other site 713604018129 G5 box; other site 713604018130 KH domain; Region: KH_2; pfam07650 713604018131 Domain of unknown function DUF21; Region: DUF21; pfam01595 713604018132 FOG: CBS domain [General function prediction only]; Region: COG0517 713604018133 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 713604018134 Transporter associated domain; Region: CorC_HlyC; smart01091 713604018135 metal-binding heat shock protein; Provisional; Region: PRK00016 713604018136 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 713604018137 PhoH-like protein; Region: PhoH; pfam02562 713604018138 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 713604018139 nucleotide binding site/active site [active] 713604018140 HIT family signature motif; other site 713604018141 catalytic residue [active] 713604018142 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 713604018143 chaperone protein DnaJ; Provisional; Region: PRK14278 713604018144 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 713604018145 HSP70 interaction site [polypeptide binding]; other site 713604018146 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 713604018147 Zn binding sites [ion binding]; other site 713604018148 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 713604018149 dimer interface [polypeptide binding]; other site 713604018150 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 713604018151 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 713604018152 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604018153 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604018154 active site 713604018155 catalytic tetrad [active] 713604018156 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 713604018157 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 713604018158 tetrameric interface [polypeptide binding]; other site 713604018159 NAD binding site [chemical binding]; other site 713604018160 catalytic residues [active] 713604018161 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 713604018162 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 713604018163 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604018164 Subtilisin inhibitor-like; Region: SSI; cl11594 713604018165 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604018166 sequence-specific DNA binding site [nucleotide binding]; other site 713604018167 salt bridge; other site 713604018168 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604018169 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 713604018170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604018171 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018172 dimerization interface [polypeptide binding]; other site 713604018173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604018174 dimer interface [polypeptide binding]; other site 713604018175 phosphorylation site [posttranslational modification] 713604018176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018177 ATP binding site [chemical binding]; other site 713604018178 Mg2+ binding site [ion binding]; other site 713604018179 G-X-G motif; other site 713604018180 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604018181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018182 active site 713604018183 phosphorylation site [posttranslational modification] 713604018184 intermolecular recognition site; other site 713604018185 dimerization interface [polypeptide binding]; other site 713604018186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604018187 DNA binding site [nucleotide binding] 713604018188 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 713604018189 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 713604018190 Na binding site [ion binding]; other site 713604018191 putative substrate binding site [chemical binding]; other site 713604018192 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 713604018193 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 713604018194 active site 713604018195 catalytic triad [active] 713604018196 dimer interface [polypeptide binding]; other site 713604018197 phenylhydantoinase; Validated; Region: PRK08323 713604018198 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 713604018199 tetramer interface [polypeptide binding]; other site 713604018200 active site 713604018201 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604018202 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 713604018203 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604018204 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604018205 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604018206 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604018207 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 713604018208 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 713604018209 FAD binding pocket [chemical binding]; other site 713604018210 FAD binding motif [chemical binding]; other site 713604018211 phosphate binding motif [ion binding]; other site 713604018212 NAD binding pocket [chemical binding]; other site 713604018213 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604018214 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604018215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018216 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604018217 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604018218 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604018219 putative NAD(P) binding site [chemical binding]; other site 713604018220 coproporphyrinogen III oxidase; Validated; Region: PRK05628 713604018221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604018222 FeS/SAM binding site; other site 713604018223 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 713604018224 putative dimer interface [polypeptide binding]; other site 713604018225 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604018226 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 713604018227 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713604018228 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713604018229 60S ribosomal protein L37a; Provisional; Region: PTZ00255; cl00875 713604018230 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 713604018231 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 713604018232 Active Sites [active] 713604018233 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 713604018234 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 713604018235 Active Sites [active] 713604018236 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 713604018237 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 713604018238 CysD dimerization site [polypeptide binding]; other site 713604018239 G1 box; other site 713604018240 putative GEF interaction site [polypeptide binding]; other site 713604018241 GTP/Mg2+ binding site [chemical binding]; other site 713604018242 Switch I region; other site 713604018243 G2 box; other site 713604018244 G3 box; other site 713604018245 Switch II region; other site 713604018246 G4 box; other site 713604018247 G5 box; other site 713604018248 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 713604018249 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 713604018250 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 713604018251 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 713604018252 putative active site [active] 713604018253 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 713604018254 active site 713604018255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018256 Mg2+ binding site [ion binding]; other site 713604018257 G-X-G motif; other site 713604018258 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 713604018259 enoyl-CoA hydratase; Provisional; Region: PRK07827 713604018260 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604018261 substrate binding site [chemical binding]; other site 713604018262 oxyanion hole (OAH) forming residues; other site 713604018263 trimer interface [polypeptide binding]; other site 713604018264 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 713604018265 putative RNAase interaction site [polypeptide binding]; other site 713604018266 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 713604018267 active site 713604018268 barstar interaction site; other site 713604018269 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604018270 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604018271 NAD(P) binding site [chemical binding]; other site 713604018272 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604018273 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604018274 amino acid transporter; Region: 2A0306; TIGR00909 713604018275 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 713604018276 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 713604018277 Nitronate monooxygenase; Region: NMO; pfam03060 713604018278 FMN binding site [chemical binding]; other site 713604018279 substrate binding site [chemical binding]; other site 713604018280 putative catalytic residue [active] 713604018281 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604018282 MarR family; Region: MarR_2; pfam12802 713604018283 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 713604018284 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 713604018285 active site 713604018286 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 713604018287 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604018288 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 713604018289 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604018290 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 713604018291 putative active site [active] 713604018292 GTP-binding protein LepA; Provisional; Region: PRK05433 713604018293 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 713604018294 G1 box; other site 713604018295 putative GEF interaction site [polypeptide binding]; other site 713604018296 GTP/Mg2+ binding site [chemical binding]; other site 713604018297 Switch I region; other site 713604018298 G2 box; other site 713604018299 G3 box; other site 713604018300 Switch II region; other site 713604018301 G4 box; other site 713604018302 G5 box; other site 713604018303 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 713604018304 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 713604018305 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 713604018306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604018307 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604018308 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604018309 active site 713604018310 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 713604018311 EamA-like transporter family; Region: EamA; pfam00892 713604018312 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 713604018313 hypothetical protein; Reviewed; Region: PRK07914 713604018314 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 713604018315 threonine synthase; Validated; Region: PRK07591 713604018316 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 713604018317 homodimer interface [polypeptide binding]; other site 713604018318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604018319 catalytic residue [active] 713604018320 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 713604018321 Competence protein; Region: Competence; pfam03772 713604018322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604018323 SLBB domain; Region: SLBB; pfam10531 713604018324 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 713604018325 EDD domain protein, DegV family; Region: DegV; TIGR00762 713604018326 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 713604018327 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604018328 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604018329 catalytic core [active] 713604018330 Oligomerisation domain; Region: Oligomerisation; cl00519 713604018331 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 713604018332 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 713604018333 active site 713604018334 (T/H)XGH motif; other site 713604018335 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 713604018336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604018337 ATP binding site [chemical binding]; other site 713604018338 putative Mg++ binding site [ion binding]; other site 713604018339 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604018340 nucleotide binding region [chemical binding]; other site 713604018341 ATP-binding site [chemical binding]; other site 713604018342 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604018343 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 713604018344 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 713604018345 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 713604018346 active site 713604018347 HIGH motif; other site 713604018348 KMSK motif region; other site 713604018349 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 713604018350 tRNA binding surface [nucleotide binding]; other site 713604018351 anticodon binding site; other site 713604018352 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604018353 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 713604018354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604018355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604018357 short chain dehydrogenase; Provisional; Region: PRK07041 713604018358 NAD(P) binding site [chemical binding]; other site 713604018359 active site 713604018360 gamma-glutamyl kinase; Provisional; Region: PRK05429 713604018361 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 713604018362 nucleotide binding site [chemical binding]; other site 713604018363 homotetrameric interface [polypeptide binding]; other site 713604018364 putative phosphate binding site [ion binding]; other site 713604018365 putative allosteric binding site; other site 713604018366 PUA domain; Region: PUA; pfam01472 713604018367 GTPase CgtA; Reviewed; Region: obgE; PRK12296 713604018368 GTP1/OBG; Region: GTP1_OBG; pfam01018 713604018369 Obg GTPase; Region: Obg; cd01898 713604018370 G1 box; other site 713604018371 GTP/Mg2+ binding site [chemical binding]; other site 713604018372 Switch I region; other site 713604018373 G2 box; other site 713604018374 G3 box; other site 713604018375 Switch II region; other site 713604018376 G4 box; other site 713604018377 G5 box; other site 713604018378 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 713604018379 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 713604018380 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 713604018381 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 713604018382 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 713604018383 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 713604018384 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 713604018385 homodimer interface [polypeptide binding]; other site 713604018386 oligonucleotide binding site [chemical binding]; other site 713604018387 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 713604018388 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604018389 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604018390 active site 713604018391 catalytic residues [active] 713604018392 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604018393 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604018394 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604018395 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604018396 nodulation ABC transporter NodI; Provisional; Region: PRK13537 713604018397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604018398 Walker A/P-loop; other site 713604018399 ATP binding site [chemical binding]; other site 713604018400 Q-loop/lid; other site 713604018401 ABC transporter signature motif; other site 713604018402 Walker B; other site 713604018403 D-loop; other site 713604018404 H-loop/switch region; other site 713604018405 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 713604018406 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604018407 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604018408 active site 713604018409 metal binding site [ion binding]; metal-binding site 713604018410 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604018411 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604018412 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 713604018413 active site 713604018414 multimer interface [polypeptide binding]; other site 713604018415 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 713604018416 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 713604018417 putative active site [active] 713604018418 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604018419 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604018420 Penicillin amidase; Region: Penicil_amidase; pfam01804 713604018421 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604018422 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604018423 active site 713604018424 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604018425 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 713604018426 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 713604018427 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713604018428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604018429 S-adenosylmethionine binding site [chemical binding]; other site 713604018430 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 713604018431 active site 713604018432 catalytic triad [active] 713604018433 oxyanion hole [active] 713604018434 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604018435 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604018436 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604018437 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 713604018438 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604018439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604018440 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604018441 dimerization interface [polypeptide binding]; other site 713604018442 substrate binding pocket [chemical binding]; other site 713604018443 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 713604018444 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 713604018445 HIGH motif; other site 713604018446 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 713604018447 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 713604018448 active site 713604018449 KMSKS motif; other site 713604018450 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 713604018451 tRNA binding surface [nucleotide binding]; other site 713604018452 anticodon binding site; other site 713604018453 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 713604018454 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604018455 MarR family; Region: MarR; pfam01047 713604018456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604018457 putative substrate translocation pore; other site 713604018458 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 713604018459 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 713604018460 putative molybdopterin cofactor binding site [chemical binding]; other site 713604018461 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 713604018462 putative molybdopterin cofactor binding site; other site 713604018463 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604018464 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 713604018465 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 713604018466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604018467 putative substrate translocation pore; other site 713604018468 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 713604018469 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 713604018470 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 713604018471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604018472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018473 WHG domain; Region: WHG; pfam13305 713604018474 Putative esterase; Region: Esterase; pfam00756 713604018475 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 713604018476 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604018477 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 713604018478 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 713604018479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604018480 Walker A motif; other site 713604018481 ATP binding site [chemical binding]; other site 713604018482 Walker B motif; other site 713604018483 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 713604018484 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 713604018485 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 713604018486 oligomer interface [polypeptide binding]; other site 713604018487 active site residues [active] 713604018488 Clp protease; Region: CLP_protease; pfam00574 713604018489 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 713604018490 oligomer interface [polypeptide binding]; other site 713604018491 active site residues [active] 713604018492 trigger factor; Provisional; Region: tig; PRK01490 713604018493 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 713604018494 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 713604018495 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604018496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018497 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604018498 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 713604018499 putative di-iron ligands [ion binding]; other site 713604018500 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 713604018501 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 713604018502 FAD binding pocket [chemical binding]; other site 713604018503 FAD binding motif [chemical binding]; other site 713604018504 phosphate binding motif [ion binding]; other site 713604018505 beta-alpha-beta structure motif; other site 713604018506 NAD(p) ribose binding residues [chemical binding]; other site 713604018507 NAD binding pocket [chemical binding]; other site 713604018508 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 713604018509 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604018510 catalytic loop [active] 713604018511 iron binding site [ion binding]; other site 713604018512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604018513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604018514 dimer interface [polypeptide binding]; other site 713604018515 phosphorylation site [posttranslational modification] 713604018516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018517 ATP binding site [chemical binding]; other site 713604018518 Mg2+ binding site [ion binding]; other site 713604018519 G-X-G motif; other site 713604018520 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 713604018521 thiamine monophosphate kinase; Provisional; Region: PRK05731 713604018522 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 713604018523 ATP binding site [chemical binding]; other site 713604018524 dimerization interface [polypeptide binding]; other site 713604018525 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 713604018526 trimer interface [polypeptide binding]; other site 713604018527 active site 713604018528 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604018529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604018530 non-specific DNA binding site [nucleotide binding]; other site 713604018531 salt bridge; other site 713604018532 sequence-specific DNA binding site [nucleotide binding]; other site 713604018533 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604018534 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604018535 ligand binding site [chemical binding]; other site 713604018536 flexible hinge region; other site 713604018537 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 713604018538 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604018539 active site 713604018540 Predicted membrane protein [Function unknown]; Region: COG2246 713604018541 GtrA-like protein; Region: GtrA; pfam04138 713604018542 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 713604018543 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604018544 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604018545 DNA binding site [nucleotide binding] 713604018546 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604018547 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 713604018548 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 713604018549 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604018550 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604018551 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 713604018552 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604018553 active site 713604018554 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 713604018555 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 713604018556 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604018557 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604018558 Walker A/P-loop; other site 713604018559 ATP binding site [chemical binding]; other site 713604018560 Q-loop/lid; other site 713604018561 ABC transporter signature motif; other site 713604018562 Walker B; other site 713604018563 D-loop; other site 713604018564 H-loop/switch region; other site 713604018565 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 713604018566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018567 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604018568 active site 713604018569 catalytic residues [active] 713604018570 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604018571 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 713604018572 non-specific DNA interactions [nucleotide binding]; other site 713604018573 DNA binding site [nucleotide binding] 713604018574 sequence specific DNA binding site [nucleotide binding]; other site 713604018575 putative cAMP binding site [chemical binding]; other site 713604018576 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604018577 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604018578 xylose isomerase; Provisional; Region: PRK12677 713604018579 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 713604018580 Trehalose utilisation; Region: ThuA; pfam06283 713604018581 MarR family; Region: MarR; pfam01047 713604018582 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604018583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604018584 putative substrate translocation pore; other site 713604018585 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604018586 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604018587 active site 713604018588 catalytic tetrad [active] 713604018589 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604018590 Ycf48-like protein; Provisional; Region: PRK13684 713604018591 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604018592 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 713604018593 intracellular protease, PfpI family; Region: PfpI; TIGR01382 713604018594 proposed catalytic triad [active] 713604018595 conserved cys residue [active] 713604018596 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604018597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018598 dimerization interface [polypeptide binding]; other site 713604018599 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 713604018600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018601 dimerization interface [polypeptide binding]; other site 713604018602 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018603 dimerization interface [polypeptide binding]; other site 713604018604 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018605 dimerization interface [polypeptide binding]; other site 713604018606 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 713604018607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018608 dimerization interface [polypeptide binding]; other site 713604018609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018610 dimerization interface [polypeptide binding]; other site 713604018611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018612 dimerization interface [polypeptide binding]; other site 713604018613 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018614 dimerization interface [polypeptide binding]; other site 713604018615 GAF domain; Region: GAF_2; pfam13185 713604018616 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604018617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604018618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604018619 dimer interface [polypeptide binding]; other site 713604018620 phosphorylation site [posttranslational modification] 713604018621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018622 ATP binding site [chemical binding]; other site 713604018623 Mg2+ binding site [ion binding]; other site 713604018624 G-X-G motif; other site 713604018625 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 713604018626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018627 active site 713604018628 phosphorylation site [posttranslational modification] 713604018629 intermolecular recognition site; other site 713604018630 dimerization interface [polypeptide binding]; other site 713604018631 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 713604018632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604018633 S-adenosylmethionine binding site [chemical binding]; other site 713604018634 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 713604018635 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604018636 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604018637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604018638 non-specific DNA binding site [nucleotide binding]; other site 713604018639 salt bridge; other site 713604018640 sequence-specific DNA binding site [nucleotide binding]; other site 713604018641 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 713604018642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 713604018643 motif II; other site 713604018644 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 713604018645 active site 713604018646 NTP binding site [chemical binding]; other site 713604018647 metal binding triad [ion binding]; metal-binding site 713604018648 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 713604018649 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604018650 putative NAD(P) binding site [chemical binding]; other site 713604018651 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 713604018652 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 713604018653 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 713604018654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604018655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604018656 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604018657 dimerization interface [polypeptide binding]; other site 713604018658 substrate binding pocket [chemical binding]; other site 713604018659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604018660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018661 short chain dehydrogenase; Provisional; Region: PRK06500 713604018662 classical (c) SDRs; Region: SDR_c; cd05233 713604018663 NAD(P) binding site [chemical binding]; other site 713604018664 active site 713604018665 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 713604018666 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 713604018667 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604018668 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604018669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604018670 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604018671 NAD(P) binding site [chemical binding]; other site 713604018672 active site 713604018673 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604018674 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604018675 alpha-galactosidase; Region: PLN02808; cl17638 713604018676 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 713604018677 Ca binding site [ion binding]; other site 713604018678 Ca binding site (active) [ion binding]; other site 713604018679 ligand binding site [chemical binding]; other site 713604018680 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604018681 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604018682 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604018683 AAA domain; Region: AAA_27; pfam13514 713604018684 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604018685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018686 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 713604018687 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 713604018688 ring oligomerisation interface [polypeptide binding]; other site 713604018689 ATP/Mg binding site [chemical binding]; other site 713604018690 stacking interactions; other site 713604018691 hinge regions; other site 713604018692 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 713604018693 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 713604018694 putative DNA binding site [nucleotide binding]; other site 713604018695 catalytic residue [active] 713604018696 putative H2TH interface [polypeptide binding]; other site 713604018697 putative catalytic residues [active] 713604018698 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604018699 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 713604018700 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 713604018701 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604018702 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 713604018703 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 713604018704 catalytic residues [active] 713604018705 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 713604018706 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 713604018707 Zn binding site [ion binding]; other site 713604018708 Repair protein; Region: Repair_PSII; pfam04536 713604018709 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 713604018710 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604018711 active site 713604018712 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 713604018713 Mechanosensitive ion channel; Region: MS_channel; pfam00924 713604018714 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 713604018715 apolar tunnel; other site 713604018716 heme binding site [chemical binding]; other site 713604018717 dimerization interface [polypeptide binding]; other site 713604018718 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 713604018719 active site 713604018720 catalytic site [active] 713604018721 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 713604018722 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 713604018723 active site 713604018724 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 713604018725 transcription termination factor Rho; Provisional; Region: PRK12678 713604018726 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 713604018727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604018728 Walker A/P-loop; other site 713604018729 ATP binding site [chemical binding]; other site 713604018730 Q-loop/lid; other site 713604018731 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604018732 ABC transporter; Region: ABC_tran_2; pfam12848 713604018733 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604018734 Copper resistance protein D; Region: CopD; pfam05425 713604018735 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 713604018736 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604018737 catalytic core [active] 713604018738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604018739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018740 ATP binding site [chemical binding]; other site 713604018741 Mg2+ binding site [ion binding]; other site 713604018742 G-X-G motif; other site 713604018743 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 713604018744 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604018745 inhibitor-cofactor binding pocket; inhibition site 713604018746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604018747 catalytic residue [active] 713604018748 choline dehydrogenase; Validated; Region: PRK02106 713604018749 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604018750 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 713604018751 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 713604018752 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604018753 active site 713604018754 choline dehydrogenase; Validated; Region: PRK02106 713604018755 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604018756 conserved hypothetical protein; Region: TIGR02246 713604018757 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604018758 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 713604018759 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 713604018760 dimer interface [polypeptide binding]; other site 713604018761 catalytic triad [active] 713604018762 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604018763 conserved hypothetical protein; Region: TIGR02246 713604018764 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 713604018765 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 713604018766 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604018767 NAD binding site [chemical binding]; other site 713604018768 catalytic residues [active] 713604018769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604018770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604018771 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604018772 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604018773 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604018774 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604018775 active site 713604018776 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604018777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604018778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604018779 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 713604018780 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 713604018781 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604018782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604018783 NAD(P) binding site [chemical binding]; other site 713604018784 active site 713604018785 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 713604018786 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 713604018787 active site 713604018788 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604018789 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 713604018790 active site 713604018791 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604018792 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604018793 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 713604018794 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604018795 putative NADP binding site [chemical binding]; other site 713604018796 active site 713604018797 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604018798 TIGR03084 family protein; Region: TIGR03084 713604018799 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604018800 Wyosine base formation; Region: Wyosine_form; pfam08608 713604018801 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 713604018802 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 713604018803 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604018804 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 713604018805 Cytochrome P450; Region: p450; pfam00067 713604018806 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604018807 Family description; Region: VCBS; pfam13517 713604018808 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 713604018809 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 713604018810 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 713604018811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604018812 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604018813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604018814 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604018815 DNA binding site [nucleotide binding] 713604018816 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604018817 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604018818 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604018819 SCP-2 sterol transfer family; Region: SCP2; cl01225 713604018820 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604018821 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604018822 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604018823 YCII-related domain; Region: YCII; cl00999 713604018824 TIGR03084 family protein; Region: TIGR03084 713604018825 Wyosine base formation; Region: Wyosine_form; pfam08608 713604018826 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 713604018827 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 713604018828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604018829 Histidine kinase; Region: HisKA_3; pfam07730 713604018830 Histidine kinase; Region: HisKA_3; pfam07730 713604018831 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604018832 ATP binding site [chemical binding]; other site 713604018833 Mg2+ binding site [ion binding]; other site 713604018834 G-X-G motif; other site 713604018835 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604018836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018837 active site 713604018838 phosphorylation site [posttranslational modification] 713604018839 intermolecular recognition site; other site 713604018840 dimerization interface [polypeptide binding]; other site 713604018841 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604018842 DNA binding residues [nucleotide binding] 713604018843 dimerization interface [polypeptide binding]; other site 713604018844 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604018845 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604018846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604018847 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604018848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018849 active site 713604018850 phosphorylation site [posttranslational modification] 713604018851 intermolecular recognition site; other site 713604018852 dimerization interface [polypeptide binding]; other site 713604018853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604018854 DNA binding residues [nucleotide binding] 713604018855 dimerization interface [polypeptide binding]; other site 713604018856 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604018857 Histidine kinase; Region: HisKA_3; pfam07730 713604018858 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 713604018859 NADPH bind site [chemical binding]; other site 713604018860 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 713604018861 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 713604018862 YcaO-like family; Region: YcaO; pfam02624 713604018863 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604018864 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604018865 CopC domain; Region: CopC; cl01012 713604018866 Copper resistance protein D; Region: CopD; cl00563 713604018867 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604018868 CAAX protease self-immunity; Region: Abi; pfam02517 713604018869 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 713604018870 putative homotetramer interface [polypeptide binding]; other site 713604018871 putative homodimer interface [polypeptide binding]; other site 713604018872 putative allosteric switch controlling residues; other site 713604018873 putative metal binding site [ion binding]; other site 713604018874 putative homodimer-homodimer interface [polypeptide binding]; other site 713604018875 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 713604018876 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604018877 metal-binding site [ion binding] 713604018878 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604018879 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604018880 metal-binding site [ion binding] 713604018881 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 713604018882 active site 713604018883 SAM binding site [chemical binding]; other site 713604018884 homodimer interface [polypeptide binding]; other site 713604018885 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604018886 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604018887 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 713604018888 malonic semialdehyde reductase; Provisional; Region: PRK10538 713604018889 putative NAD(P) binding site [chemical binding]; other site 713604018890 homotetramer interface [polypeptide binding]; other site 713604018891 homodimer interface [polypeptide binding]; other site 713604018892 active site 713604018893 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 713604018894 FO synthase; Reviewed; Region: fbiC; PRK09234 713604018895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604018896 FeS/SAM binding site; other site 713604018897 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604018898 FeS/SAM binding site; other site 713604018899 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 713604018900 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 713604018901 Probable molybdopterin binding domain; Region: MoCF_biosynth; smart00852 713604018902 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 713604018903 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604018904 Methyltransferase domain; Region: Methyltransf_11; pfam08241 713604018905 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604018906 putative metal binding site [ion binding]; other site 713604018907 Right handed beta helix region; Region: Beta_helix; pfam13229 713604018908 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604018909 sugar binding site [chemical binding]; other site 713604018910 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604018911 putative metal binding site [ion binding]; other site 713604018912 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 713604018913 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604018914 sugar binding site [chemical binding]; other site 713604018915 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604018916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018917 active site 713604018918 phosphorylation site [posttranslational modification] 713604018919 intermolecular recognition site; other site 713604018920 dimerization interface [polypeptide binding]; other site 713604018921 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604018922 DNA binding site [nucleotide binding] 713604018923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604018924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018925 dimerization interface [polypeptide binding]; other site 713604018926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604018927 dimer interface [polypeptide binding]; other site 713604018928 phosphorylation site [posttranslational modification] 713604018929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018930 ATP binding site [chemical binding]; other site 713604018931 Mg2+ binding site [ion binding]; other site 713604018932 G-X-G motif; other site 713604018933 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604018934 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604018935 DNA binding site [nucleotide binding] 713604018936 domain linker motif; other site 713604018937 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 713604018938 putative dimerization interface [polypeptide binding]; other site 713604018939 putative ligand binding site [chemical binding]; other site 713604018940 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604018941 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604018942 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604018943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604018944 dimer interface [polypeptide binding]; other site 713604018945 conserved gate region; other site 713604018946 putative PBP binding loops; other site 713604018947 ABC-ATPase subunit interface; other site 713604018948 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604018949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604018950 dimer interface [polypeptide binding]; other site 713604018951 conserved gate region; other site 713604018952 putative PBP binding loops; other site 713604018953 ABC-ATPase subunit interface; other site 713604018954 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 713604018955 active site 713604018956 catalytic site [active] 713604018957 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 713604018958 AAA ATPase domain; Region: AAA_16; pfam13191 713604018959 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604018960 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 713604018961 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 713604018962 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 713604018963 Ligand Binding Site [chemical binding]; other site 713604018964 Molecular Tunnel; other site 713604018965 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604018966 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604018967 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604018968 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 713604018969 Uncharacterized conserved protein [Function unknown]; Region: COG5276 713604018970 Uncharacterized conserved protein [Function unknown]; Region: COG5276 713604018971 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 713604018972 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 713604018973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604018974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604018975 LysR substrate binding domain; Region: LysR_substrate; pfam03466 713604018976 dimerization interface [polypeptide binding]; other site 713604018977 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604018978 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 713604018979 NAD(P) binding site [chemical binding]; other site 713604018980 active site 713604018981 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604018982 classical (c) SDRs; Region: SDR_c; cd05233 713604018983 NAD(P) binding site [chemical binding]; other site 713604018984 active site 713604018985 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 713604018986 putative active site [active] 713604018987 putative catalytic triad [active] 713604018988 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604018989 catalytic residues [active] 713604018990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604018991 Coenzyme A binding pocket [chemical binding]; other site 713604018992 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 713604018993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604018994 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604018995 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604018996 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604018997 putative acyl-acceptor binding pocket; other site 713604018998 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604018999 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604019000 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604019001 DNA binding site [nucleotide binding] 713604019002 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604019003 dimerization interface [polypeptide binding]; other site 713604019004 ligand binding site [chemical binding]; other site 713604019005 Protein of unknown function (DUF993); Region: DUF993; pfam06187 713604019006 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604019007 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604019008 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 713604019009 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604019010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604019011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604019012 active site 713604019013 phosphorylation site [posttranslational modification] 713604019014 intermolecular recognition site; other site 713604019015 dimerization interface [polypeptide binding]; other site 713604019016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604019017 DNA binding site [nucleotide binding] 713604019018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604019019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604019020 dimer interface [polypeptide binding]; other site 713604019021 phosphorylation site [posttranslational modification] 713604019022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604019023 ATP binding site [chemical binding]; other site 713604019024 Mg2+ binding site [ion binding]; other site 713604019025 G-X-G motif; other site 713604019026 amino acid transporter; Region: 2A0306; TIGR00909 713604019027 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 713604019028 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 713604019029 Predicted amidohydrolase [General function prediction only]; Region: COG0388 713604019030 putative active site [active] 713604019031 catalytic triad [active] 713604019032 putative dimer interface [polypeptide binding]; other site 713604019033 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604019034 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 713604019035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604019036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019037 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604019038 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604019039 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604019040 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604019041 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 713604019042 active site 713604019043 catalytic triad [active] 713604019044 oxyanion hole [active] 713604019045 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604019046 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 713604019047 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604019048 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 713604019049 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604019050 active site 713604019051 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019052 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604019053 acyl-activating enzyme (AAE) consensus motif; other site 713604019054 AMP binding site [chemical binding]; other site 713604019055 active site 713604019056 CoA binding site [chemical binding]; other site 713604019057 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 713604019058 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 713604019059 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604019060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604019061 dimerization interface [polypeptide binding]; other site 713604019062 putative DNA binding site [nucleotide binding]; other site 713604019063 putative Zn2+ binding site [ion binding]; other site 713604019064 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604019065 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604019066 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604019067 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 713604019068 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604019069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604019070 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604019071 dimerization interface [polypeptide binding]; other site 713604019072 substrate binding pocket [chemical binding]; other site 713604019073 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 713604019074 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 713604019075 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 713604019076 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 713604019077 NAD binding site [chemical binding]; other site 713604019078 Phe binding site; other site 713604019079 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604019080 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604019081 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 713604019082 PaaX-like protein; Region: PaaX; pfam07848 713604019083 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 713604019084 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 713604019085 Creatinine amidohydrolase; Region: Creatininase; pfam02633 713604019086 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019087 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 713604019088 acyl-activating enzyme (AAE) consensus motif; other site 713604019089 AMP binding site [chemical binding]; other site 713604019090 active site 713604019091 CoA binding site [chemical binding]; other site 713604019092 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604019093 classical (c) SDRs; Region: SDR_c; cd05233 713604019094 NAD(P) binding site [chemical binding]; other site 713604019095 active site 713604019096 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604019097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019098 substrate binding site [chemical binding]; other site 713604019099 oxyanion hole (OAH) forming residues; other site 713604019100 trimer interface [polypeptide binding]; other site 713604019101 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 713604019102 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 713604019103 active site 713604019104 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604019105 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604019106 active site 713604019107 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 713604019108 Strictosidine synthase; Region: Str_synth; pfam03088 713604019109 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604019110 catalytic core [active] 713604019111 Phosphotransferase enzyme family; Region: APH; pfam01636 713604019112 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 713604019113 putative active site [active] 713604019114 putative substrate binding site [chemical binding]; other site 713604019115 ATP binding site [chemical binding]; other site 713604019116 short chain dehydrogenase; Provisional; Region: PRK08251 713604019117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019118 NAD(P) binding site [chemical binding]; other site 713604019119 active site 713604019120 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 713604019121 cyclase homology domain; Region: CHD; cd07302 713604019122 AAA ATPase domain; Region: AAA_16; pfam13191 713604019123 Predicted ATPase [General function prediction only]; Region: COG3903 713604019124 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604019125 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604019126 DNA binding residues [nucleotide binding] 713604019127 dimerization interface [polypeptide binding]; other site 713604019128 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604019129 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604019130 acyl-CoA synthetase; Validated; Region: PRK07788 713604019131 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019132 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604019133 acyl-activating enzyme (AAE) consensus motif; other site 713604019134 putative AMP binding site [chemical binding]; other site 713604019135 putative active site [active] 713604019136 putative CoA binding site [chemical binding]; other site 713604019137 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 713604019138 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 713604019139 active site 713604019140 DNA binding site [nucleotide binding] 713604019141 catalytic site [active] 713604019142 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 713604019143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604019144 ATP binding site [chemical binding]; other site 713604019145 putative Mg++ binding site [ion binding]; other site 713604019146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604019147 nucleotide binding region [chemical binding]; other site 713604019148 ATP-binding site [chemical binding]; other site 713604019149 Helicase associated domain (HA2); Region: HA2; pfam04408 713604019150 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 713604019151 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 713604019152 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 713604019153 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 713604019154 putative active site [active] 713604019155 putative substrate binding site [chemical binding]; other site 713604019156 putative FMN binding site [chemical binding]; other site 713604019157 putative catalytic residues [active] 713604019158 Uncharacterized conserved protein [Function unknown]; Region: COG3268 713604019159 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604019160 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604019161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019162 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 713604019163 chitosan binding site [chemical binding]; other site 713604019164 catalytic residues [active] 713604019165 hypothetical protein; Provisional; Region: PRK07945 713604019166 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 713604019167 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 713604019168 active site 713604019169 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 713604019170 active site 713604019171 metal binding site [ion binding]; metal-binding site 713604019172 homotetramer interface [polypeptide binding]; other site 713604019173 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604019174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019175 DNA-binding site [nucleotide binding]; DNA binding site 713604019176 FCD domain; Region: FCD; pfam07729 713604019177 dihydroxy-acid dehydratase; Validated; Region: PRK06131 713604019178 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 713604019179 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 713604019180 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 713604019181 VanW like protein; Region: VanW; pfam04294 713604019182 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604019183 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604019184 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604019185 metal binding site [ion binding]; metal-binding site 713604019186 active site 713604019187 I-site; other site 713604019188 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 713604019189 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 713604019190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604019191 catalytic residue [active] 713604019192 Dienelactone hydrolase family; Region: DLH; pfam01738 713604019193 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604019194 YCII-related domain; Region: YCII; cl00999 713604019195 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 713604019196 rRNA binding site [nucleotide binding]; other site 713604019197 predicted 30S ribosome binding site; other site 713604019198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604019199 Coenzyme A binding pocket [chemical binding]; other site 713604019200 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019201 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604019202 active site 713604019203 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019204 active site 713604019205 metal binding site [ion binding]; metal-binding site 713604019206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019207 DNA-binding site [nucleotide binding]; DNA binding site 713604019208 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604019209 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604019210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604019211 homodimer interface [polypeptide binding]; other site 713604019212 catalytic residue [active] 713604019213 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 713604019214 H2TH interface [polypeptide binding]; other site 713604019215 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 713604019216 DNA binding site [nucleotide binding] 713604019217 putative catalytic residues [active] 713604019218 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604019219 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604019220 DinB superfamily; Region: DinB_2; pfam12867 713604019221 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 713604019222 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 713604019223 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 713604019224 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604019225 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604019226 Cytochrome P450; Region: p450; cl12078 713604019227 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019228 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604019229 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604019230 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019231 Cytochrome P450; Region: p450; cl12078 713604019232 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604019233 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 713604019234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604019235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019236 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604019237 FAD binding domain; Region: FAD_binding_4; pfam01565 713604019238 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 713604019239 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604019240 GAF domain; Region: GAF; pfam01590 713604019241 Histidine kinase; Region: HisKA_3; pfam07730 713604019242 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604019243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604019244 active site 713604019245 phosphorylation site [posttranslational modification] 713604019246 intermolecular recognition site; other site 713604019247 dimerization interface [polypeptide binding]; other site 713604019248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604019249 DNA binding residues [nucleotide binding] 713604019250 dimerization interface [polypeptide binding]; other site 713604019251 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 713604019252 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 713604019253 active site 713604019254 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 713604019255 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 713604019256 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 713604019257 Walker A/P-loop; other site 713604019258 ATP binding site [chemical binding]; other site 713604019259 Q-loop/lid; other site 713604019260 ABC transporter signature motif; other site 713604019261 Walker B; other site 713604019262 D-loop; other site 713604019263 H-loop/switch region; other site 713604019264 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604019265 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 713604019266 Walker A/P-loop; other site 713604019267 ATP binding site [chemical binding]; other site 713604019268 Q-loop/lid; other site 713604019269 ABC transporter signature motif; other site 713604019270 Walker B; other site 713604019271 D-loop; other site 713604019272 H-loop/switch region; other site 713604019273 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 713604019274 TM-ABC transporter signature motif; other site 713604019275 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 713604019276 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 713604019277 TM-ABC transporter signature motif; other site 713604019278 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604019279 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 713604019280 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604019281 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604019282 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604019283 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604019284 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604019285 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 713604019286 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604019287 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 713604019288 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 713604019289 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 713604019290 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 713604019291 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 713604019292 active site 713604019293 dimer interface [polypeptide binding]; other site 713604019294 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 713604019295 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 713604019296 active site 713604019297 FMN binding site [chemical binding]; other site 713604019298 substrate binding site [chemical binding]; other site 713604019299 3Fe-4S cluster binding site [ion binding]; other site 713604019300 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 713604019301 domain interface; other site 713604019302 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 713604019303 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604019304 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 713604019305 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604019306 putative NAD(P) binding site [chemical binding]; other site 713604019307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604019308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019309 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 713604019310 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604019311 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604019312 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 713604019313 cobyric acid synthase; Provisional; Region: PRK00784 713604019314 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 713604019315 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 713604019316 catalytic triad [active] 713604019317 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 713604019318 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 713604019319 homotrimer interface [polypeptide binding]; other site 713604019320 Walker A motif; other site 713604019321 GTP binding site [chemical binding]; other site 713604019322 Walker B motif; other site 713604019323 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 713604019324 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 713604019325 putative dimer interface [polypeptide binding]; other site 713604019326 active site pocket [active] 713604019327 putative cataytic base [active] 713604019328 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 713604019329 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604019330 HTH domain; Region: HTH_11; pfam08279 713604019331 WYL domain; Region: WYL; pfam13280 713604019332 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604019333 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604019334 hypothetical protein; Provisional; Region: PRK07908 713604019335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604019336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604019337 homodimer interface [polypeptide binding]; other site 713604019338 catalytic residue [active] 713604019339 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 713604019340 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 713604019341 catalytic triad [active] 713604019342 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 713604019343 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 713604019344 homodimer interface [polypeptide binding]; other site 713604019345 Walker A motif; other site 713604019346 ATP binding site [chemical binding]; other site 713604019347 hydroxycobalamin binding site [chemical binding]; other site 713604019348 Walker B motif; other site 713604019349 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 713604019350 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 713604019351 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 713604019352 metal ion-dependent adhesion site (MIDAS); other site 713604019353 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 713604019354 active site 713604019355 putative homodimer interface [polypeptide binding]; other site 713604019356 SAM binding site [chemical binding]; other site 713604019357 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 713604019358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604019359 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 713604019360 active site 713604019361 homodimer interface [polypeptide binding]; other site 713604019362 SAM binding site [chemical binding]; other site 713604019363 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604019364 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604019365 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604019366 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 713604019367 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 713604019368 putative FMN binding site [chemical binding]; other site 713604019369 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 713604019370 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 713604019371 active site 713604019372 SAM binding site [chemical binding]; other site 713604019373 homodimer interface [polypeptide binding]; other site 713604019374 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 713604019375 homodimer interface [polypeptide binding]; other site 713604019376 active site 713604019377 SAM binding site [chemical binding]; other site 713604019378 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 713604019379 Precorrin-8X methylmutase; Region: CbiC; pfam02570 713604019380 precorrin-3B synthase; Region: CobG; TIGR02435 713604019381 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713604019382 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713604019383 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604019384 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604019385 Walker A/P-loop; other site 713604019386 ATP binding site [chemical binding]; other site 713604019387 Q-loop/lid; other site 713604019388 ABC transporter signature motif; other site 713604019389 Walker B; other site 713604019390 D-loop; other site 713604019391 H-loop/switch region; other site 713604019392 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604019393 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604019394 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604019395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604019396 non-specific DNA binding site [nucleotide binding]; other site 713604019397 salt bridge; other site 713604019398 sequence-specific DNA binding site [nucleotide binding]; other site 713604019399 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 713604019400 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 713604019401 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 713604019402 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 713604019403 active site 713604019404 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 713604019405 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604019406 RibD C-terminal domain; Region: RibD_C; cl17279 713604019407 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 713604019408 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 713604019409 catalytic motif [active] 713604019410 Zn binding site [ion binding]; other site 713604019411 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604019412 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 713604019413 NAD(P) binding site [chemical binding]; other site 713604019414 catalytic residues [active] 713604019415 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 713604019416 DDE superfamily endonuclease; Region: DDE_5; pfam13546 713604019417 AlkA N-terminal domain; Region: AlkA_N; cl05528 713604019418 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 713604019419 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 713604019420 helix-hairpin-helix signature motif; other site 713604019421 active site 713604019422 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 713604019423 amidohydrolase; Region: amidohydrolases; TIGR01891 713604019424 metal binding site [ion binding]; metal-binding site 713604019425 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604019426 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 713604019427 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 713604019428 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 713604019429 putative active site [active] 713604019430 putative substrate binding site [chemical binding]; other site 713604019431 dimer interface [polypeptide binding]; other site 713604019432 catalytic site [active] 713604019433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604019434 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604019435 putative substrate translocation pore; other site 713604019436 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 713604019437 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 713604019438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 713604019439 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604019440 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 713604019441 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 713604019442 Int/Topo IB signature motif; other site 713604019443 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604019444 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 713604019445 DNA methylase; Region: N6_N4_Mtase; pfam01555 713604019446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 713604019447 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 713604019448 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 713604019449 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604019450 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 713604019451 Walker A motif; other site 713604019452 ATP binding site [chemical binding]; other site 713604019453 Walker B motif; other site 713604019454 hypothetical protein; Provisional; Region: PRK06847 713604019455 hypothetical protein; Provisional; Region: PRK07236 713604019456 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604019457 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604019458 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604019459 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604019460 Helix-turn-helix domain; Region: HTH_31; pfam13560 713604019461 Homeodomain-like domain; Region: HTH_23; pfam13384 713604019462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604019463 sequence-specific DNA binding site [nucleotide binding]; other site 713604019464 salt bridge; other site 713604019465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604019466 sequence-specific DNA binding site [nucleotide binding]; other site 713604019467 salt bridge; other site 713604019468 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604019469 nudix motif; other site 713604019470 potential frameshift: common BLAST hit: gi|256375421|ref|YP_003099081.1| taurine catabolism dioxygenase TauD/TfdA 713604019471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604019472 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 713604019473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019475 active site 713604019476 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604019477 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604019478 NAD(P) binding site [chemical binding]; other site 713604019479 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 713604019480 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 713604019481 tetramer interface [polypeptide binding]; other site 713604019482 TPP-binding site [chemical binding]; other site 713604019483 heterodimer interface [polypeptide binding]; other site 713604019484 phosphorylation loop region [posttranslational modification] 713604019485 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 713604019486 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 713604019487 alpha subunit interface [polypeptide binding]; other site 713604019488 TPP binding site [chemical binding]; other site 713604019489 heterodimer interface [polypeptide binding]; other site 713604019490 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604019491 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604019492 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019493 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604019494 acyl-activating enzyme (AAE) consensus motif; other site 713604019495 acyl-activating enzyme (AAE) consensus motif; other site 713604019496 putative AMP binding site [chemical binding]; other site 713604019497 putative active site [active] 713604019498 putative CoA binding site [chemical binding]; other site 713604019499 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604019500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019501 NAD(P) binding site [chemical binding]; other site 713604019502 active site 713604019503 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604019504 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019505 substrate binding site [chemical binding]; other site 713604019506 oxyanion hole (OAH) forming residues; other site 713604019507 trimer interface [polypeptide binding]; other site 713604019508 Putative cyclase; Region: Cyclase; pfam04199 713604019509 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019510 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019511 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604019512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604019513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019514 active site 713604019515 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 713604019516 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 713604019517 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 713604019518 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 713604019519 active site 713604019520 non-prolyl cis peptide bond; other site 713604019521 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604019522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019523 DNA-binding site [nucleotide binding]; DNA binding site 713604019524 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604019525 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604019526 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 713604019527 NAD(P) binding site [chemical binding]; other site 713604019528 catalytic residues [active] 713604019529 catalytic residues [active] 713604019530 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604019531 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604019532 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604019533 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604019534 Putative cyclase; Region: Cyclase; pfam04199 713604019535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019536 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 713604019537 NAD(P) binding site [chemical binding]; other site 713604019538 active site 713604019539 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604019540 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604019541 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019542 active site 713604019543 metal binding site [ion binding]; metal-binding site 713604019544 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019545 Cytochrome P450; Region: p450; cl12078 713604019546 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604019547 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604019548 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604019549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604019550 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604019551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019552 NAD(P) binding site [chemical binding]; other site 713604019553 active site 713604019554 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604019555 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604019556 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604019557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604019558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019560 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604019561 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604019562 putative NAD(P) binding site [chemical binding]; other site 713604019563 DoxX-like family; Region: DoxX_2; pfam13564 713604019564 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 713604019565 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 713604019566 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 713604019567 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604019568 NAD binding site [chemical binding]; other site 713604019569 substrate binding site [chemical binding]; other site 713604019570 putative active site [active] 713604019571 potential frameshift: common BLAST hit: gi|269125756|ref|YP_003299126.1| NmrA family protein 713604019572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604019573 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 713604019574 Walker A/P-loop; other site 713604019575 ATP binding site [chemical binding]; other site 713604019576 Q-loop/lid; other site 713604019577 ABC transporter signature motif; other site 713604019578 Walker B; other site 713604019579 D-loop; other site 713604019580 H-loop/switch region; other site 713604019581 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604019582 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 713604019583 TM-ABC transporter signature motif; other site 713604019584 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 713604019585 TM-ABC transporter signature motif; other site 713604019586 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604019587 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 713604019588 Walker A/P-loop; other site 713604019589 ATP binding site [chemical binding]; other site 713604019590 Q-loop/lid; other site 713604019591 ABC transporter signature motif; other site 713604019592 Walker B; other site 713604019593 D-loop; other site 713604019594 H-loop/switch region; other site 713604019595 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 713604019596 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 713604019597 putative ligand binding site [chemical binding]; other site 713604019598 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604019599 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019600 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019601 active site 713604019602 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019603 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604019604 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604019605 active site 713604019606 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 713604019607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019608 NAD(P) binding site [chemical binding]; other site 713604019609 active site 713604019610 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019611 DNA-binding site [nucleotide binding]; DNA binding site 713604019612 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604019613 FCD domain; Region: FCD; pfam07729 713604019614 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604019615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019616 DNA-binding site [nucleotide binding]; DNA binding site 713604019617 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604019618 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 713604019619 active site 713604019620 catalytic site [active] 713604019621 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604019622 active site 2 [active] 713604019623 active site 1 [active] 713604019624 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 713604019625 classical (c) SDRs; Region: SDR_c; cd05233 713604019626 NAD(P) binding site [chemical binding]; other site 713604019627 active site 713604019628 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604019629 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 713604019630 NAD(P) binding site [chemical binding]; other site 713604019631 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019633 active site 713604019634 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019635 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604019636 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 713604019637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604019638 active site 713604019639 metal binding site [ion binding]; metal-binding site 713604019640 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 713604019641 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019642 Cytochrome P450; Region: p450; cl12078 713604019643 enoyl-CoA hydratase; Provisional; Region: PRK08252 713604019644 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019645 substrate binding site [chemical binding]; other site 713604019646 oxyanion hole (OAH) forming residues; other site 713604019647 trimer interface [polypeptide binding]; other site 713604019648 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 713604019649 putative active site [active] 713604019650 putative substrate binding site [chemical binding]; other site 713604019651 ATP binding site [chemical binding]; other site 713604019652 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019653 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019654 active site 713604019655 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604019656 classical (c) SDRs; Region: SDR_c; cd05233 713604019657 NAD(P) binding site [chemical binding]; other site 713604019658 active site 713604019659 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 713604019660 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 713604019661 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604019662 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604019663 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604019664 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604019665 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 713604019666 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604019667 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 713604019668 classical (c) SDRs; Region: SDR_c; cd05233 713604019669 NAD(P) binding site [chemical binding]; other site 713604019670 active site 713604019671 Amidohydrolase; Region: Amidohydro_2; pfam04909 713604019672 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 713604019673 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 713604019674 thiolase; Provisional; Region: PRK06158 713604019675 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604019676 active site 713604019677 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 713604019678 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604019679 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604019680 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604019681 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604019682 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 713604019683 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019684 active site 713604019685 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019686 active site 713604019687 metal binding site [ion binding]; metal-binding site 713604019688 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 713604019689 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019690 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019691 active site 713604019692 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 713604019693 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 713604019694 classical (c) SDRs; Region: SDR_c; cd05233 713604019695 NAD(P) binding site [chemical binding]; other site 713604019696 active site 713604019697 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604019698 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 713604019699 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604019700 dimer interface [polypeptide binding]; other site 713604019701 active site 713604019702 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604019703 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604019704 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019705 substrate binding site [chemical binding]; other site 713604019706 oxyanion hole (OAH) forming residues; other site 713604019707 trimer interface [polypeptide binding]; other site 713604019708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019710 active site 713604019711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019712 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604019713 NAD(P) binding site [chemical binding]; other site 713604019714 active site 713604019715 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019716 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604019717 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604019718 acyl-activating enzyme (AAE) consensus motif; other site 713604019719 putative AMP binding site [chemical binding]; other site 713604019720 putative active site [active] 713604019721 putative CoA binding site [chemical binding]; other site 713604019722 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019723 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604019724 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019725 acyl-activating enzyme (AAE) consensus motif; other site 713604019726 acyl-activating enzyme (AAE) consensus motif; other site 713604019727 AMP binding site [chemical binding]; other site 713604019728 active site 713604019729 CoA binding site [chemical binding]; other site 713604019730 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019731 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 713604019732 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604019733 acyl-activating enzyme (AAE) consensus motif; other site 713604019734 putative AMP binding site [chemical binding]; other site 713604019735 putative active site [active] 713604019736 putative CoA binding site [chemical binding]; other site 713604019737 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019738 substrate binding site [chemical binding]; other site 713604019739 oxyanion hole (OAH) forming residues; other site 713604019740 trimer interface [polypeptide binding]; other site 713604019741 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604019742 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 713604019743 dimer interface [polypeptide binding]; other site 713604019744 active site 713604019745 enoyl-CoA hydratase; Provisional; Region: PRK05864 713604019746 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019747 substrate binding site [chemical binding]; other site 713604019748 oxyanion hole (OAH) forming residues; other site 713604019749 trimer interface [polypeptide binding]; other site 713604019750 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604019751 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 713604019752 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604019753 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604019754 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 713604019755 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604019756 active site 713604019757 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604019758 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604019759 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604019760 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019761 substrate binding site [chemical binding]; other site 713604019762 oxyanion hole (OAH) forming residues; other site 713604019763 trimer interface [polypeptide binding]; other site 713604019764 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 713604019765 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 713604019766 dihydropteroate synthase; Region: DHPS; TIGR01496 713604019767 substrate binding pocket [chemical binding]; other site 713604019768 dimer interface [polypeptide binding]; other site 713604019769 inhibitor binding site; inhibition site 713604019770 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604019771 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604019772 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 713604019773 NAD binding site [chemical binding]; other site 713604019774 catalytic residues [active] 713604019775 Predicted acyl esterases [General function prediction only]; Region: COG2936 713604019776 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604019777 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019778 Cytochrome P450; Region: p450; cl12078 713604019779 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 713604019780 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604019781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604019782 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 713604019783 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019784 NAD(P) binding site [chemical binding]; other site 713604019785 active site 713604019786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604019787 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604019788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604019789 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 713604019790 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604019791 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604019792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019793 NAD(P) binding site [chemical binding]; other site 713604019794 active site 713604019795 enoyl-CoA hydratase; Provisional; Region: PRK06688 713604019796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604019797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019798 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604019799 potential frameshift: common BLAST hit: gi|300788950|ref|YP_003769241.1| 2-oxoisovalerate dehydrogenase E1 component 713604019800 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604019801 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019802 Cytochrome P450; Region: p450; cl12078 713604019803 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019804 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604019805 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604019806 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604019807 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 713604019808 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604019809 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604019810 NAD(P) binding site [chemical binding]; other site 713604019811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604019812 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604019813 ATP binding site [chemical binding]; other site 713604019814 Mg2+ binding site [ion binding]; other site 713604019815 G-X-G motif; other site 713604019816 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604019817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604019818 active site 713604019819 phosphorylation site [posttranslational modification] 713604019820 intermolecular recognition site; other site 713604019821 dimerization interface [polypeptide binding]; other site 713604019822 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604019823 DNA binding residues [nucleotide binding] 713604019824 dimerization interface [polypeptide binding]; other site 713604019825 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019826 CoA binding site [chemical binding]; other site 713604019827 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019828 acyl-activating enzyme (AAE) consensus motif; other site 713604019829 active site 713604019830 AMP binding site [chemical binding]; other site 713604019831 CoA binding site [chemical binding]; other site 713604019832 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604019833 galactonate dehydratase; Provisional; Region: PRK14017 713604019834 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 713604019835 active site pocket [active] 713604019836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604019837 D-galactonate transporter; Region: 2A0114; TIGR00893 713604019838 putative substrate translocation pore; other site 713604019839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604019840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604019841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604019842 dimerization interface [polypeptide binding]; other site 713604019843 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604019844 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604019845 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 713604019846 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604019847 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 713604019848 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604019849 NAD binding site [chemical binding]; other site 713604019850 substrate binding site [chemical binding]; other site 713604019851 putative active site [active] 713604019852 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604019853 aldolase II superfamily protein; Provisional; Region: PRK07044 713604019854 intersubunit interface [polypeptide binding]; other site 713604019855 active site 713604019856 Zn2+ binding site [ion binding]; other site 713604019857 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604019858 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604019859 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 713604019860 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604019861 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 713604019862 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604019863 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604019864 Domain of unknown function (DUF336); Region: DUF336; cl01249 713604019865 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604019866 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604019867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604019868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604019869 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604019870 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604019871 DNA binding site [nucleotide binding] 713604019872 domain linker motif; other site 713604019873 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604019874 dimerization interface [polypeptide binding]; other site 713604019875 ligand binding site [chemical binding]; other site 713604019876 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604019877 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604019878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604019879 dimer interface [polypeptide binding]; other site 713604019880 conserved gate region; other site 713604019881 putative PBP binding loops; other site 713604019882 ABC-ATPase subunit interface; other site 713604019883 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604019884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604019885 dimer interface [polypeptide binding]; other site 713604019886 conserved gate region; other site 713604019887 putative PBP binding loops; other site 713604019888 ABC-ATPase subunit interface; other site 713604019889 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 713604019890 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 713604019891 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604019892 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604019893 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604019894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019895 DNA-binding site [nucleotide binding]; DNA binding site 713604019896 FCD domain; Region: FCD; pfam07729 713604019897 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604019898 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604019899 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 713604019900 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604019901 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604019902 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604019903 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604019904 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604019905 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 713604019906 NAD binding site [chemical binding]; other site 713604019907 ligand binding site [chemical binding]; other site 713604019908 catalytic site [active] 713604019909 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 713604019910 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 713604019911 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 713604019912 enoyl-CoA hydratase; Provisional; Region: PRK06495 713604019913 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019914 substrate binding site [chemical binding]; other site 713604019915 oxyanion hole (OAH) forming residues; other site 713604019916 trimer interface [polypeptide binding]; other site 713604019917 glutathione synthetase; Provisional; Region: PRK05246 713604019918 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 713604019919 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 713604019920 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604019921 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 713604019922 active site 713604019923 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604019924 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604019925 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604019926 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 713604019927 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 713604019928 putative C-terminal domain interface [polypeptide binding]; other site 713604019929 putative GSH binding site (G-site) [chemical binding]; other site 713604019930 putative dimer interface [polypeptide binding]; other site 713604019931 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 713604019932 N-terminal domain interface [polypeptide binding]; other site 713604019933 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604019934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019935 DNA-binding site [nucleotide binding]; DNA binding site 713604019936 UTRA domain; Region: UTRA; cl17743 713604019937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604019938 D-galactonate transporter; Region: 2A0114; TIGR00893 713604019939 putative substrate translocation pore; other site 713604019940 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 713604019941 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 713604019942 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 713604019943 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604019944 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604019945 potential frameshift: common BLAST hit: gi|78356950|ref|YP_388399.1| phage head morphogenesis protein 713604019946 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604019947 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604019948 active site 713604019949 substrate binding site [chemical binding]; other site 713604019950 ATP binding site [chemical binding]; other site 713604019951 Domain of unknown function (DUF4417); Region: DUF4417; pfam14386 713604019952 ParB-like nuclease domain; Region: ParB; smart00470 713604019953 Replication-relaxation; Region: Replic_Relax; pfam13814 713604019954 Lsr2; Region: Lsr2; pfam11774 713604019955 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604019956 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 713604019957 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 713604019958 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604019959 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 713604019960 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 713604019961 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604019962 RHS Repeat; Region: RHS_repeat; pfam05593 713604019963 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604019964 RHS Repeat; Region: RHS_repeat; cl11982 713604019965 RHS Repeat; Region: RHS_repeat; cl11982 713604019966 RHS Repeat; Region: RHS_repeat; pfam05593 713604019967 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604019968 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604019969 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604019970 catalytic residue [active] 713604019971 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604019972 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604019973 AAA-like domain; Region: AAA_10; pfam12846 713604019974 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 713604019975 Uncharacterized conserved protein [Function unknown]; Region: COG4278 713604019976 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604019977 substrate binding site [chemical binding]; other site 713604019978 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019979 active site 713604019980 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 713604019981 substrate binding pocket [chemical binding]; other site 713604019982 dimer interface [polypeptide binding]; other site 713604019983 inhibitor binding site; inhibition site 713604019984 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 713604019985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604019986 non-specific DNA binding site [nucleotide binding]; other site 713604019987 salt bridge; other site 713604019988 sequence-specific DNA binding site [nucleotide binding]; other site 713604019989 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 713604019990 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 713604019991 putative transposase OrfB; Reviewed; Region: PHA02517 713604019992 HTH-like domain; Region: HTH_21; pfam13276 713604019993 Integrase core domain; Region: rve; pfam00665 713604019994 Integrase core domain; Region: rve_3; pfam13683 713604019995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604019996 Transposase; Region: HTH_Tnp_1; cl17663 713604019997 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604019998 hydrophobic ligand binding site; other site 713604019999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020000 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604020001 NAD(P) binding site [chemical binding]; other site 713604020002 active site 713604020003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604020004 putative DNA binding site [nucleotide binding]; other site 713604020005 putative Zn2+ binding site [ion binding]; other site 713604020006 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604020007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020008 NAD(P) binding site [chemical binding]; other site 713604020009 active site 713604020010 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604020011 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604020012 FO synthase; Reviewed; Region: fbiC; PRK09234 713604020013 FO synthase; Reviewed; Region: fbiC; PRK09234 713604020014 FO synthase; Reviewed; Region: fbiC; PRK09234 713604020015 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604020016 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604020017 short chain dehydrogenase; Provisional; Region: PRK06172 713604020018 classical (c) SDRs; Region: SDR_c; cd05233 713604020019 NAD(P) binding site [chemical binding]; other site 713604020020 active site 713604020021 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 713604020022 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 713604020023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020024 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 713604020025 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604020026 Cytochrome P450; Region: p450; cl12078 713604020027 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604020028 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604020029 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604020030 DNA binding residues [nucleotide binding] 713604020031 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604020032 FAD binding domain; Region: FAD_binding_4; pfam01565 713604020033 Berberine and berberine like; Region: BBE; pfam08031 713604020034 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604020035 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604020036 RibD C-terminal domain; Region: RibD_C; cl17279 713604020037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604020038 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604020039 putative substrate translocation pore; other site 713604020040 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 713604020041 Leucine rich repeat; Region: LRR_8; pfam13855 713604020042 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604020043 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604020044 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 713604020045 protein-splicing catalytic site; other site 713604020046 thioester formation/cholesterol transfer; other site 713604020047 Pretoxin HINT domain; Region: PT-HINT; pfam07591 713604020048 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604020049 intermolecular salt bridges; other site 713604020050 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604020051 Cellulose binding domain; Region: CBM_2; cl17741 713604020052 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604020053 Methyltransferase domain; Region: Methyltransf_12; pfam08242 713604020054 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604020055 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604020056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020057 Cupin; Region: Cupin_6; pfam12852 713604020058 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604020059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020060 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604020061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020062 NAD(P) binding site [chemical binding]; other site 713604020063 active site 713604020064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604020065 active site 713604020066 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 713604020067 PBP superfamily domain; Region: PBP_like_2; cl17296 713604020068 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 713604020069 active site 713604020070 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 713604020071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020072 dimer interface [polypeptide binding]; other site 713604020073 conserved gate region; other site 713604020074 putative PBP binding loops; other site 713604020075 ABC-ATPase subunit interface; other site 713604020076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020077 dimer interface [polypeptide binding]; other site 713604020078 conserved gate region; other site 713604020079 putative PBP binding loops; other site 713604020080 ABC-ATPase subunit interface; other site 713604020081 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 713604020082 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 713604020083 Walker A/P-loop; other site 713604020084 ATP binding site [chemical binding]; other site 713604020085 Q-loop/lid; other site 713604020086 ABC transporter signature motif; other site 713604020087 Walker B; other site 713604020088 D-loop; other site 713604020089 H-loop/switch region; other site 713604020090 PBP superfamily domain; Region: PBP_like_2; cl17296 713604020091 PBP superfamily domain; Region: PBP_like_2; pfam12849 713604020092 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604020093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020094 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604020095 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604020096 active site 713604020097 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604020098 active site 713604020099 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 713604020100 active site 713604020101 catalytic triad [active] 713604020102 oxyanion hole [active] 713604020103 amidase; Provisional; Region: PRK06170 713604020104 Amidase; Region: Amidase; cl11426 713604020105 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604020106 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604020107 NAD(P) binding site [chemical binding]; other site 713604020108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604020109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604020110 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604020111 putative dimerization interface [polypeptide binding]; other site 713604020112 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604020113 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604020114 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604020115 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604020116 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604020117 putative sugar binding sites [chemical binding]; other site 713604020118 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604020119 putative sugar binding sites [chemical binding]; other site 713604020120 Q-X-W motif; other site 713604020121 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 713604020122 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604020123 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604020124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020125 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 713604020126 NAD(P) binding site [chemical binding]; other site 713604020127 active site 713604020128 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 713604020129 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604020130 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604020131 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 713604020132 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604020133 Walker A/P-loop; other site 713604020134 ATP binding site [chemical binding]; other site 713604020135 Q-loop/lid; other site 713604020136 ABC transporter signature motif; other site 713604020137 Walker B; other site 713604020138 D-loop; other site 713604020139 H-loop/switch region; other site 713604020140 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 713604020141 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 713604020142 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 713604020143 Cellulose binding domain; Region: CBM_2; pfam00553 713604020144 alpha-galactosidase; Region: PLN02808; cl17638 713604020145 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604020146 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604020147 putative sugar binding sites [chemical binding]; other site 713604020148 Q-X-W motif; other site 713604020149 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 713604020150 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 713604020151 putative active site [active] 713604020152 putative catalytic site [active] 713604020153 putative Zn binding site [ion binding]; other site 713604020154 O-Antigen ligase; Region: Wzy_C; pfam04932 713604020155 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 713604020156 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 713604020157 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604020158 putative ADP-binding pocket [chemical binding]; other site 713604020159 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 713604020160 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604020161 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604020162 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 713604020163 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604020164 TM1410 hypothetical-related protein; Region: DUF297; cl00997 713604020165 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 713604020166 Bacterial sugar transferase; Region: Bac_transf; pfam02397 713604020167 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604020168 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 713604020169 active site 713604020170 hypothetical protein; Provisional; Region: PRK07233 713604020171 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604020172 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 713604020173 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 713604020174 active site 713604020175 homodimer interface [polypeptide binding]; other site 713604020176 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 713604020177 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 713604020178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604020179 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604020180 active site 713604020181 metal binding site [ion binding]; metal-binding site 713604020182 Right handed beta helix region; Region: Beta_helix; pfam13229 713604020183 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604020184 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604020185 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604020186 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 713604020187 metal binding site [ion binding]; metal-binding site 713604020188 active site 713604020189 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 713604020190 active site 713604020191 catalytic triad [active] 713604020192 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 713604020193 active site 713604020194 catalytic triad [active] 713604020195 oxyanion hole [active] 713604020196 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604020197 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604020198 Interdomain contacts; other site 713604020199 Cellulose binding domain; Region: CBM_2; pfam00553 713604020200 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 713604020201 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604020202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604020203 DNA binding site [nucleotide binding] 713604020204 domain linker motif; other site 713604020205 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604020206 dimerization interface [polypeptide binding]; other site 713604020207 ligand binding site [chemical binding]; other site 713604020208 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604020209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020210 dimer interface [polypeptide binding]; other site 713604020211 conserved gate region; other site 713604020212 putative PBP binding loops; other site 713604020213 ABC-ATPase subunit interface; other site 713604020214 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 713604020215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020216 putative PBP binding loops; other site 713604020217 ABC-ATPase subunit interface; other site 713604020218 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604020219 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604020220 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 713604020221 active site 713604020222 catalytic triad [active] 713604020223 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604020224 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604020225 anti sigma factor interaction site; other site 713604020226 regulatory phosphorylation site [posttranslational modification]; other site 713604020227 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 713604020228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020230 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604020231 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604020232 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604020233 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 713604020234 catalytic site [active] 713604020235 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604020236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604020237 PAS domain; Region: PAS_9; pfam13426 713604020238 putative active site [active] 713604020239 heme pocket [chemical binding]; other site 713604020240 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604020241 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604020242 anti sigma factor interaction site; other site 713604020243 regulatory phosphorylation site [posttranslational modification]; other site 713604020244 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 713604020245 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 713604020246 dimer interface [polypeptide binding]; other site 713604020247 active site 713604020248 catalytic residue [active] 713604020249 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604020250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604020251 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604020252 putative dimerization interface [polypeptide binding]; other site 713604020253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604020254 S-adenosylmethionine binding site [chemical binding]; other site 713604020255 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 713604020256 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 713604020257 glutaminase active site [active] 713604020258 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 713604020259 dimer interface [polypeptide binding]; other site 713604020260 active site 713604020261 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 713604020262 dimer interface [polypeptide binding]; other site 713604020263 active site 713604020264 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604020265 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604020266 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604020267 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604020268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020269 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604020270 Cytochrome P450; Region: p450; cl12078 713604020271 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604020272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020274 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604020275 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604020276 active site 713604020277 catalytic tetrad [active] 713604020278 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604020279 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604020280 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604020281 MarR family; Region: MarR_2; cl17246 713604020282 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604020283 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 713604020284 Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662 713604020285 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604020286 Interdomain contacts; other site 713604020287 Cytokine receptor motif; other site 713604020288 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 713604020289 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 713604020290 active site 713604020291 PHP Thumb interface [polypeptide binding]; other site 713604020292 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 713604020293 generic binding surface I; other site 713604020294 generic binding surface II; other site 713604020295 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604020296 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604020297 DNA binding residues [nucleotide binding] 713604020298 YCII-related domain; Region: YCII; cl00999 713604020299 RibD C-terminal domain; Region: RibD_C; cl17279 713604020300 arginine decarboxylase; Provisional; Region: PRK15029 713604020301 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 713604020302 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604020303 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604020304 catalytic residue [active] 713604020305 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 713604020306 Y-family of DNA polymerases; Region: PolY; cl12025 713604020307 DNA binding site [nucleotide binding] 713604020308 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604020309 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 713604020310 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604020311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604020312 DNA-binding site [nucleotide binding]; DNA binding site 713604020313 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604020314 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604020315 Walker A/P-loop; other site 713604020316 ATP binding site [chemical binding]; other site 713604020317 Q-loop/lid; other site 713604020318 ABC transporter signature motif; other site 713604020319 Walker B; other site 713604020320 D-loop; other site 713604020321 H-loop/switch region; other site 713604020322 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 713604020323 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 713604020324 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 713604020325 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604020326 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 713604020327 active site 713604020328 catalytic triad [active] 713604020329 oxyanion hole [active] 713604020330 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604020331 classical (c) SDRs; Region: SDR_c; cd05233 713604020332 NAD(P) binding site [chemical binding]; other site 713604020333 active site 713604020334 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 713604020335 Ferritin-like domain; Region: Ferritin; pfam00210 713604020336 ferroxidase diiron center [ion binding]; other site 713604020337 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604020338 CoenzymeA binding site [chemical binding]; other site 713604020339 subunit interaction site [polypeptide binding]; other site 713604020340 PHB binding site; other site 713604020341 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 713604020342 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 713604020343 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604020344 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604020345 G1 box; other site 713604020346 GTP/Mg2+ binding site [chemical binding]; other site 713604020347 G2 box; other site 713604020348 Switch I region; other site 713604020349 G3 box; other site 713604020350 Switch II region; other site 713604020351 G4 box; other site 713604020352 G5 box; other site 713604020353 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604020354 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 713604020355 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604020356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604020357 ATP binding site [chemical binding]; other site 713604020358 Mg2+ binding site [ion binding]; other site 713604020359 G-X-G motif; other site 713604020360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604020361 dimerization interface [polypeptide binding]; other site 713604020362 putative DNA binding site [nucleotide binding]; other site 713604020363 putative Zn2+ binding site [ion binding]; other site 713604020364 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604020365 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 713604020366 putative NAD(P) binding site [chemical binding]; other site 713604020367 active site 713604020368 putative substrate binding site [chemical binding]; other site 713604020369 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 713604020370 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604020371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604020372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604020373 DNA binding residues [nucleotide binding] 713604020374 dimerization interface [polypeptide binding]; other site 713604020375 Tannase and feruloyl esterase; Region: Tannase; pfam07519 713604020376 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604020377 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604020378 active site 713604020379 catalytic tetrad [active] 713604020380 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604020381 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604020382 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 713604020383 active site 713604020384 GAF domain; Region: GAF_2; pfam13185 713604020385 ANTAR domain; Region: ANTAR; pfam03861 713604020386 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 713604020387 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604020388 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604020389 putative sugar binding sites [chemical binding]; other site 713604020390 Q-X-W motif; other site 713604020391 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 713604020392 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 713604020393 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 713604020394 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 713604020395 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604020396 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604020397 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604020398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020399 putative PBP binding loops; other site 713604020400 ABC-ATPase subunit interface; other site 713604020401 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 713604020402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604020403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020404 dimer interface [polypeptide binding]; other site 713604020405 ABC-ATPase subunit interface; other site 713604020406 putative PBP binding loops; other site 713604020407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604020408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604020409 DNA binding site [nucleotide binding] 713604020410 domain linker motif; other site 713604020411 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 713604020412 ligand binding site [chemical binding]; other site 713604020413 dimerization interface (open form) [polypeptide binding]; other site 713604020414 dimerization interface (closed form) [polypeptide binding]; other site 713604020415 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 713604020416 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 713604020417 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604020418 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604020419 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 713604020420 putative NAD(P) binding site [chemical binding]; other site 713604020421 tetracycline repressor protein TetR; Provisional; Region: PRK13756 713604020422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020423 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604020424 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 713604020425 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 713604020426 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 713604020427 Fasciclin domain; Region: Fasciclin; pfam02469 713604020428 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 713604020429 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 713604020430 Moco binding site; other site 713604020431 metal coordination site [ion binding]; other site 713604020432 putative anti-sigmaE protein; Provisional; Region: PRK13920 713604020433 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 713604020434 Anti-sigma-K factor rskA; Region: RskA; pfam10099 713604020435 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 713604020436 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604020437 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604020438 DNA binding residues [nucleotide binding] 713604020439 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 713604020440 acyl-CoA synthetase; Validated; Region: PRK06188 713604020441 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604020442 active site 713604020443 CoA binding site [chemical binding]; other site 713604020444 AMP binding site [chemical binding]; other site 713604020445 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 713604020446 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 713604020447 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 713604020448 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604020449 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604020450 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 713604020451 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 713604020452 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604020453 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713604020454 RNA binding surface [nucleotide binding]; other site 713604020455 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604020456 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604020457 DNA binding residues [nucleotide binding] 713604020458 Cupin domain; Region: Cupin_2; pfam07883 713604020459 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 713604020460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604020461 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604020462 DNA binding residues [nucleotide binding] 713604020463 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604020464 active site 713604020465 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604020466 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604020467 metal binding site [ion binding]; metal-binding site 713604020468 active site 713604020469 I-site; other site 713604020470 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604020471 Putative cyclase; Region: Cyclase; cl00814 713604020472 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604020473 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604020474 Glyco_18 domain; Region: Glyco_18; smart00636 713604020475 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 713604020476 active site 713604020477 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 713604020478 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604020479 catalytic residue [active] 713604020480 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604020481 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604020482 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604020483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604020484 S-adenosylmethionine binding site [chemical binding]; other site 713604020485 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604020486 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 713604020487 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604020488 non-specific DNA binding site [nucleotide binding]; other site 713604020489 salt bridge; other site 713604020490 sequence-specific DNA binding site [nucleotide binding]; other site 713604020491 amidase; Provisional; Region: PRK07869 713604020492 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 713604020493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604020494 S-adenosylmethionine binding site [chemical binding]; other site 713604020495 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604020496 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604020497 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 713604020498 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604020499 Methyltransferase domain; Region: Methyltransf_24; pfam13578 713604020500 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 713604020501 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604020502 metal ion-dependent adhesion site (MIDAS); other site 713604020503 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 713604020504 active site 713604020505 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604020506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604020507 DNA-binding site [nucleotide binding]; DNA binding site 713604020508 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604020509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604020510 homodimer interface [polypeptide binding]; other site 713604020511 catalytic residue [active] 713604020512 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604020513 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604020514 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604020515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604020516 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 713604020517 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 713604020518 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604020519 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604020520 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604020521 protein binding site [polypeptide binding]; other site 713604020522 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 713604020523 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604020524 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 713604020525 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 713604020526 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 713604020527 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 713604020528 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 713604020529 putative active site [active] 713604020530 putative substrate binding site [chemical binding]; other site 713604020531 putative cosubstrate binding site; other site 713604020532 catalytic site [active] 713604020533 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 713604020534 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 713604020535 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 713604020536 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604020537 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 713604020538 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 713604020539 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 713604020540 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 713604020541 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604020542 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604020543 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 713604020544 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 713604020545 dimer interface [polypeptide binding]; other site 713604020546 active site 713604020547 glycine-pyridoxal phosphate binding site [chemical binding]; other site 713604020548 folate binding site [chemical binding]; other site 713604020549 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604020550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604020551 DNA-binding site [nucleotide binding]; DNA binding site 713604020552 FCD domain; Region: FCD; pfam07729 713604020553 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 713604020554 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 713604020555 [2Fe-2S] cluster binding site [ion binding]; other site 713604020556 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 713604020557 putative alpha subunit interface [polypeptide binding]; other site 713604020558 putative active site [active] 713604020559 putative substrate binding site [chemical binding]; other site 713604020560 Fe binding site [ion binding]; other site 713604020561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 713604020562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020563 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604020564 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 713604020565 tetramerization interface [polypeptide binding]; other site 713604020566 NAD(P) binding site [chemical binding]; other site 713604020567 catalytic residues [active] 713604020568 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 713604020569 choline dehydrogenase; Validated; Region: PRK02106 713604020570 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604020571 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 713604020572 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604020573 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 713604020574 [2Fe-2S] cluster binding site [ion binding]; other site 713604020575 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604020576 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604020577 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604020578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020579 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 713604020580 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 713604020581 E3 interaction surface; other site 713604020582 lipoyl attachment site [posttranslational modification]; other site 713604020583 e3 binding domain; Region: E3_binding; pfam02817 713604020584 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 713604020585 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 713604020586 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 713604020587 TPP binding site [chemical binding]; other site 713604020588 alpha subunit interface [polypeptide binding]; other site 713604020589 heterodimer interface [polypeptide binding]; other site 713604020590 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604020591 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 713604020592 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 713604020593 tetramer interface [polypeptide binding]; other site 713604020594 TPP-binding site [chemical binding]; other site 713604020595 heterodimer interface [polypeptide binding]; other site 713604020596 phosphorylation loop region [posttranslational modification] 713604020597 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604020598 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604020599 AsnC family; Region: AsnC_trans_reg; pfam01037 713604020600 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 713604020601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604020602 Coenzyme A binding pocket [chemical binding]; other site 713604020603 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604020604 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604020605 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604020606 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604020607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604020608 active site 713604020609 phosphorylation site [posttranslational modification] 713604020610 intermolecular recognition site; other site 713604020611 dimerization interface [polypeptide binding]; other site 713604020612 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604020613 DNA binding site [nucleotide binding] 713604020614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604020615 dimerization interface [polypeptide binding]; other site 713604020616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604020617 dimer interface [polypeptide binding]; other site 713604020618 phosphorylation site [posttranslational modification] 713604020619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604020620 ATP binding site [chemical binding]; other site 713604020621 Mg2+ binding site [ion binding]; other site 713604020622 G-X-G motif; other site 713604020623 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 713604020624 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604020625 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 713604020626 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604020627 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 713604020628 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 713604020629 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 713604020630 putative active site [active] 713604020631 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604020632 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604020633 active site 713604020634 ATP binding site [chemical binding]; other site 713604020635 substrate binding site [chemical binding]; other site 713604020636 activation loop (A-loop); other site 713604020637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604020638 dimerization interface [polypeptide binding]; other site 713604020639 putative DNA binding site [nucleotide binding]; other site 713604020640 putative Zn2+ binding site [ion binding]; other site 713604020641 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 713604020642 putative hydrophobic ligand binding site [chemical binding]; other site 713604020643 Imelysin; Region: Peptidase_M75; pfam09375 713604020644 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 713604020645 Phosphoesterase family; Region: Phosphoesterase; pfam04185 713604020646 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604020647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604020648 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604020649 anti sigma factor interaction site; other site 713604020650 regulatory phosphorylation site [posttranslational modification]; other site 713604020651 Response regulator receiver domain; Region: Response_reg; pfam00072 713604020652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604020653 active site 713604020654 phosphorylation site [posttranslational modification] 713604020655 intermolecular recognition site; other site 713604020656 dimerization interface [polypeptide binding]; other site 713604020657 CHASE3 domain; Region: CHASE3; pfam05227 713604020658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604020659 dimerization interface [polypeptide binding]; other site 713604020660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604020661 dimer interface [polypeptide binding]; other site 713604020662 phosphorylation site [posttranslational modification] 713604020663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604020664 ATP binding site [chemical binding]; other site 713604020665 Mg2+ binding site [ion binding]; other site 713604020666 G-X-G motif; other site 713604020667 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 713604020668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604020669 active site 713604020670 phosphorylation site [posttranslational modification] 713604020671 intermolecular recognition site; other site 713604020672 dimerization interface [polypeptide binding]; other site 713604020673 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604020674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 713604020675 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 713604020676 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604020677 Secretory lipase; Region: LIP; pfam03583 713604020678 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604020679 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604020680 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604020681 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604020682 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604020683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020684 KR domain; Region: KR; pfam08659 713604020685 NAD(P) binding site [chemical binding]; other site 713604020686 active site 713604020687 mce related protein; Region: MCE; pfam02470 713604020688 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604020689 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604020690 mce related protein; Region: MCE; pfam02470 713604020691 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604020692 mce related protein; Region: MCE; pfam02470 713604020693 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604020694 mce related protein; Region: MCE; pfam02470 713604020695 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604020696 mce related protein; Region: MCE; pfam02470 713604020697 mce related protein; Region: MCE; pfam02470 713604020698 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604020699 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604020700 Permease; Region: Permease; pfam02405 713604020701 Permease; Region: Permease; pfam02405 713604020702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604020703 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604020704 Walker A/P-loop; other site 713604020705 ATP binding site [chemical binding]; other site 713604020706 Q-loop/lid; other site 713604020707 ABC transporter signature motif; other site 713604020708 Walker B; other site 713604020709 D-loop; other site 713604020710 H-loop/switch region; other site 713604020711 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604020712 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604020713 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604020714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604020715 binding surface 713604020716 TPR motif; other site 713604020717 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604020718 CHAT domain; Region: CHAT; pfam12770 713604020719 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604020720 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604020721 active site 713604020722 metal binding site [ion binding]; metal-binding site 713604020723 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 713604020724 Growth-arrest specific micro-tubule binding; Region: GAS; pfam13851 713604020725 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604020726 nudix motif; other site 713604020727 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604020728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020729 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604020730 hypothetical protein; Provisional; Region: PRK14059 713604020731 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 713604020732 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 713604020733 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604020734 active site 713604020735 ATP binding site [chemical binding]; other site 713604020736 substrate binding site [chemical binding]; other site 713604020737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020739 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604020740 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 713604020741 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 713604020742 Hemerythrin-like domain; Region: Hr-like; cd12108 713604020743 Fe binding site [ion binding]; other site 713604020744 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604020745 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604020746 acyl-activating enzyme (AAE) consensus motif; other site 713604020747 AMP binding site [chemical binding]; other site 713604020748 active site 713604020749 CoA binding site [chemical binding]; other site 713604020750 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 713604020751 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604020752 molybdopterin cofactor binding site; other site 713604020753 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 713604020754 molybdopterin cofactor binding site; other site 713604020755 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 713604020756 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604020757 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604020758 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604020759 hydrophobic ligand binding site; other site 713604020760 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604020761 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604020762 Cupin domain; Region: Cupin_2; cl17218 713604020763 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604020764 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604020765 conserved cys residue [active] 713604020766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020770 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604020771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604020772 Coenzyme A binding pocket [chemical binding]; other site 713604020773 Protein of unknown function DUF111; Region: DUF111; cl03398 713604020774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604020775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604020776 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604020777 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 713604020778 Domain of unknown function (DUF222); Region: DUF222; pfam02720 713604020779 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604020780 active site 713604020781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604020782 Coenzyme A binding pocket [chemical binding]; other site 713604020783 short chain dehydrogenase; Provisional; Region: PRK07041 713604020784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020785 NAD(P) binding site [chemical binding]; other site 713604020786 active site 713604020787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604020788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604020789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 713604020790 dimerization interface [polypeptide binding]; other site 713604020791 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604020792 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604020793 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604020794 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 713604020795 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 713604020796 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 713604020797 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604020798 putative active site [active] 713604020799 putative metal binding site [ion binding]; other site 713604020800 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604020801 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604020802 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 713604020803 putative ADP-ribose binding site [chemical binding]; other site 713604020804 putative active site [active] 713604020805 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 713604020806 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 713604020807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604020808 motif II; other site 713604020809 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 713604020810 nudix motif; other site 713604020811 Predicted membrane protein [Function unknown]; Region: COG2259 713604020812 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604020813 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604020814 G1 box; other site 713604020815 GTP/Mg2+ binding site [chemical binding]; other site 713604020816 G2 box; other site 713604020817 Switch I region; other site 713604020818 G3 box; other site 713604020819 Switch II region; other site 713604020820 G4 box; other site 713604020821 G5 box; other site 713604020822 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604020823 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604020824 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604020825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604020826 ATP binding site [chemical binding]; other site 713604020827 Mg2+ binding site [ion binding]; other site 713604020828 G-X-G motif; other site 713604020829 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 713604020830 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604020831 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 713604020832 acyl-activating enzyme (AAE) consensus motif; other site 713604020833 acyl-activating enzyme (AAE) consensus motif; other site 713604020834 putative AMP binding site [chemical binding]; other site 713604020835 putative active site [active] 713604020836 putative CoA binding site [chemical binding]; other site 713604020837 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604020838 classical (c) SDRs; Region: SDR_c; cd05233 713604020839 NAD(P) binding site [chemical binding]; other site 713604020840 active site 713604020841 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604020842 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604020843 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604020844 metal binding site [ion binding]; metal-binding site 713604020845 active site 713604020846 I-site; other site 713604020847 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 713604020848 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604020849 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 713604020850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604020851 non-specific DNA binding site [nucleotide binding]; other site 713604020852 salt bridge; other site 713604020853 sequence-specific DNA binding site [nucleotide binding]; other site 713604020854 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604020855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604020856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020858 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 713604020859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020860 NAD(P) binding site [chemical binding]; other site 713604020861 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604020862 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604020863 conserved cys residue [active] 713604020864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020866 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604020867 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604020868 active site 713604020869 catalytic tetrad [active] 713604020870 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 713604020871 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 713604020872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020873 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 713604020874 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 713604020875 catalytic triad [active] 713604020876 NACHT domain; Region: NACHT; pfam05729 713604020877 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 713604020878 active site 713604020879 dimerization interface [polypeptide binding]; other site 713604020880 ribonuclease PH; Reviewed; Region: rph; PRK00173 713604020881 Ribonuclease PH; Region: RNase_PH_bact; cd11362 713604020882 hexamer interface [polypeptide binding]; other site 713604020883 active site 713604020884 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 713604020885 glutamate racemase; Provisional; Region: PRK00865 713604020886 Rhomboid family; Region: Rhomboid; pfam01694 713604020887 N-acetyltransferase; Region: Acetyltransf_2; cl00949 713604020888 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 713604020889 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 713604020890 aspartate racemase; Region: asp_race; TIGR00035 713604020891 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604020892 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604020893 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 713604020894 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604020895 dimer interface [polypeptide binding]; other site 713604020896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604020897 catalytic residue [active] 713604020898 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 713604020899 MoaE interaction surface [polypeptide binding]; other site 713604020900 MoeB interaction surface [polypeptide binding]; other site 713604020901 thiocarboxylated glycine; other site 713604020902 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 713604020903 MPN+ (JAMM) motif; other site 713604020904 Zinc-binding site [ion binding]; other site 713604020905 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 713604020906 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 713604020907 cleavage site 713604020908 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 713604020909 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 713604020910 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 713604020911 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 713604020912 active site 713604020913 Isochorismatase family; Region: Isochorismatase; pfam00857 713604020914 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 713604020915 catalytic triad [active] 713604020916 conserved cis-peptide bond; other site 713604020917 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 713604020918 active site 713604020919 intersubunit interface [polypeptide binding]; other site 713604020920 catalytic residue [active] 713604020921 BioY family; Region: BioY; pfam02632 713604020922 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 713604020923 DEAD/DEAH box helicase; Region: DEAD; pfam00270 713604020924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604020925 putative Mg++ binding site [ion binding]; other site 713604020926 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 713604020927 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 713604020928 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 713604020929 dimer interface [polypeptide binding]; other site 713604020930 putative active site [active] 713604020931 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 713604020932 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 713604020933 phosphoserine phosphatase SerB; Region: serB; TIGR00338 713604020934 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 713604020935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604020936 motif II; other site 713604020937 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 713604020938 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 713604020939 D-pathway; other site 713604020940 Putative ubiquinol binding site [chemical binding]; other site 713604020941 Low-spin heme (heme b) binding site [chemical binding]; other site 713604020942 Putative water exit pathway; other site 713604020943 Binuclear center (heme o3/CuB) [ion binding]; other site 713604020944 K-pathway; other site 713604020945 Putative proton exit pathway; other site 713604020946 Phosphotransferase enzyme family; Region: APH; pfam01636 713604020947 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604020948 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604020949 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604020950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604020951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604020952 Transposase; Region: HTH_Tnp_1; pfam01527 713604020953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604020954 HTH-like domain; Region: HTH_21; pfam13276 713604020955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 713604020956 Integrase core domain; Region: rve; pfam00665 713604020957 Integrase core domain; Region: rve_3; pfam13683 713604020958 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 713604020959 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 713604020960 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 713604020961 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 713604020962 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604020963 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604020964 catalytic residue [active] 713604020965 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604020966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604020967 putative DNA binding site [nucleotide binding]; other site 713604020968 putative Zn2+ binding site [ion binding]; other site 713604020969 AsnC family; Region: AsnC_trans_reg; pfam01037 713604020970 AAA domain; Region: AAA_17; pfam13207 713604020971 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604020972 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604020973 putative DNA binding site [nucleotide binding]; other site 713604020974 putative Zn2+ binding site [ion binding]; other site 713604020975 AsnC family; Region: AsnC_trans_reg; pfam01037 713604020976 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604020977 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604020978 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 713604020979 nucleoside/Zn binding site; other site 713604020980 dimer interface [polypeptide binding]; other site 713604020981 catalytic motif [active] 713604020982 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 713604020983 homodimer interaction site [polypeptide binding]; other site 713604020984 cofactor binding site; other site 713604020985 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 713604020986 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604020987 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604020988 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 713604020989 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604020990 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604020991 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 713604020992 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 713604020993 dimerization domain swap beta strand [polypeptide binding]; other site 713604020994 regulatory protein interface [polypeptide binding]; other site 713604020995 active site 713604020996 regulatory phosphorylation site [posttranslational modification]; other site 713604020997 DAK2 domain; Region: Dak2; cl03685 713604020998 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 713604020999 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 713604021000 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 713604021001 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 713604021002 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 713604021003 Na binding site [ion binding]; other site 713604021004 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 713604021005 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 713604021006 hypothetical protein; Provisional; Region: PRK03298 713604021007 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 713604021008 dimer interface [polypeptide binding]; other site 713604021009 ADP-ribose binding site [chemical binding]; other site 713604021010 active site 713604021011 nudix motif; other site 713604021012 metal binding site [ion binding]; metal-binding site 713604021013 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 713604021014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604021015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604021016 enoyl-CoA hydratase; Validated; Region: PRK08139 713604021017 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604021018 substrate binding site [chemical binding]; other site 713604021019 oxyanion hole (OAH) forming residues; other site 713604021020 trimer interface [polypeptide binding]; other site 713604021021 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 713604021022 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604021023 conserved cys residue [active] 713604021024 Isochorismatase family; Region: Isochorismatase; pfam00857 713604021025 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 713604021026 catalytic triad [active] 713604021027 conserved cis-peptide bond; other site 713604021028 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 713604021029 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 713604021030 B12 binding site [chemical binding]; other site 713604021031 cobalt ligand [ion binding]; other site 713604021032 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 713604021033 Bacterial PH domain; Region: DUF304; cl01348 713604021034 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604021035 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604021036 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 713604021037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604021038 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604021039 NAD(P) binding site [chemical binding]; other site 713604021040 active site 713604021041 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604021042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604021043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604021044 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 713604021045 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 713604021046 hinge; other site 713604021047 active site 713604021048 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 713604021049 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 713604021050 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 713604021051 hinge; other site 713604021052 active site 713604021053 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 713604021054 ATP synthase, F1 epsilon subunit (delta in mitochondria); Region: ATP_synt_epsi; TIGR01216 713604021055 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 713604021056 gamma subunit interface [polypeptide binding]; other site 713604021057 epsilon subunit interface [polypeptide binding]; other site 713604021058 LBP interface [polypeptide binding]; other site 713604021059 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 713604021060 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 713604021061 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 713604021062 alpha subunit interaction interface [polypeptide binding]; other site 713604021063 Walker A motif; other site 713604021064 ATP binding site [chemical binding]; other site 713604021065 Walker B motif; other site 713604021066 inhibitor binding site; inhibition site 713604021067 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 713604021068 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 713604021069 core domain interface [polypeptide binding]; other site 713604021070 delta subunit interface [polypeptide binding]; other site 713604021071 epsilon subunit interface [polypeptide binding]; other site 713604021072 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 713604021073 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 713604021074 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 713604021075 beta subunit interaction interface [polypeptide binding]; other site 713604021076 Walker A motif; other site 713604021077 ATP binding site [chemical binding]; other site 713604021078 Walker B motif; other site 713604021079 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 713604021080 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 713604021081 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 713604021082 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 713604021083 ATP synthase subunit C; Region: ATP-synt_C; cl00466 713604021084 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 713604021085 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 713604021086 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 713604021087 Mg++ binding site [ion binding]; other site 713604021088 putative catalytic motif [active] 713604021089 substrate binding site [chemical binding]; other site 713604021090 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 713604021091 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 713604021092 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 713604021093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604021094 S-adenosylmethionine binding site [chemical binding]; other site 713604021095 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 713604021096 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 713604021097 Ligand binding site; other site 713604021098 Putative Catalytic site; other site 713604021099 DXD motif; other site 713604021100 Predicted membrane protein [Function unknown]; Region: COG2246 713604021101 GtrA-like protein; Region: GtrA; pfam04138 713604021102 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 713604021103 peptide chain release factor 1; Validated; Region: prfA; PRK00591 713604021104 This domain is found in peptide chain release factors; Region: PCRF; smart00937 713604021105 RF-1 domain; Region: RF-1; pfam00472 713604021106 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 713604021107 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 713604021108 transcription termination factor Rho; Provisional; Region: PRK12608 713604021109 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 713604021110 RNA binding site [nucleotide binding]; other site 713604021111 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 713604021112 multimer interface [polypeptide binding]; other site 713604021113 Walker A motif; other site 713604021114 ATP binding site [chemical binding]; other site 713604021115 Walker B motif; other site 713604021116 homoserine kinase; Provisional; Region: PRK01212 713604021117 threonine synthase; Reviewed; Region: PRK06721 713604021118 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 713604021119 homodimer interface [polypeptide binding]; other site 713604021120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021121 catalytic residue [active] 713604021122 homoserine dehydrogenase; Provisional; Region: PRK06349 713604021123 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 713604021124 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 713604021125 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 713604021126 diaminopimelate decarboxylase; Region: lysA; TIGR01048 713604021127 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 713604021128 active site 713604021129 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604021130 substrate binding site [chemical binding]; other site 713604021131 catalytic residues [active] 713604021132 dimer interface [polypeptide binding]; other site 713604021133 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 713604021134 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 713604021135 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 713604021136 active site 713604021137 HIGH motif; other site 713604021138 KMSK motif region; other site 713604021139 tRNA binding surface [nucleotide binding]; other site 713604021140 DALR anticodon binding domain; Region: DALR_1; smart00836 713604021141 anticodon binding site; other site 713604021142 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 713604021143 Domain of unknown function (DUF305); Region: DUF305; pfam03713 713604021144 RIP homotypic interaction motif; Region: RHIM; pfam12721 713604021145 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 713604021146 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604021147 MarR family; Region: MarR; pfam01047 713604021148 short chain dehydrogenase; Provisional; Region: PRK05993 713604021149 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604021150 NADP binding site [chemical binding]; other site 713604021151 active site 713604021152 steroid binding site; other site 713604021153 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604021154 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604021155 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 713604021156 active site 713604021157 catalytic residues [active] 713604021158 DNA binding site [nucleotide binding] 713604021159 Int/Topo IB signature motif; other site 713604021160 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604021161 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 713604021162 putative NAD(P) binding site [chemical binding]; other site 713604021163 TIGR03086 family protein; Region: TIGR03086 713604021164 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604021165 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604021166 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604021167 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604021168 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604021169 Transposase; Region: HTH_Tnp_1; cl17663 713604021170 putative transposase OrfB; Reviewed; Region: PHA02517 713604021171 HTH-like domain; Region: HTH_21; pfam13276 713604021172 Integrase core domain; Region: rve; pfam00665 713604021173 Integrase core domain; Region: rve_3; pfam13683 713604021174 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 713604021175 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604021176 substrate binding site [chemical binding]; other site 713604021177 ATP binding site [chemical binding]; other site 713604021178 Survival protein SurE; Region: SurE; cl00448 713604021179 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604021180 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604021181 AAA ATPase domain; Region: AAA_16; pfam13191 713604021182 NB-ARC domain; Region: NB-ARC; pfam00931 713604021183 TPR repeat; Region: TPR_11; pfam13414 713604021184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604021185 TPR motif; other site 713604021186 binding surface 713604021187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604021188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604021189 TPR motif; other site 713604021190 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604021191 binding surface 713604021192 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604021193 Cytochrome P450; Region: p450; cl12078 713604021194 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 713604021195 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 713604021196 Right handed beta helix region; Region: Beta_helix; pfam13229 713604021197 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604021198 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604021199 putative sugar binding sites [chemical binding]; other site 713604021200 Q-X-W motif; other site 713604021201 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604021202 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604021203 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604021204 alpha-galactosidase; Region: PLN02808; cl17638 713604021205 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604021206 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604021207 putative sugar binding sites [chemical binding]; other site 713604021208 Q-X-W motif; other site 713604021209 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604021210 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604021211 putative sugar binding sites [chemical binding]; other site 713604021212 Q-X-W motif; other site 713604021213 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 713604021214 active site 713604021215 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 713604021216 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604021217 Interdomain contacts; other site 713604021218 Cytokine receptor motif; other site 713604021219 Cellulose binding domain; Region: CBM_2; cl17741 713604021220 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604021221 MarR family; Region: MarR_2; pfam12802 713604021222 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604021223 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604021224 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604021225 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604021226 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604021227 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604021228 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604021229 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604021230 putative sugar binding sites [chemical binding]; other site 713604021231 Q-X-W motif; other site 713604021232 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604021233 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604021234 putative sugar binding sites [chemical binding]; other site 713604021235 Q-X-W motif; other site 713604021236 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 713604021237 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 713604021238 Cellulose binding domain; Region: CBM_2; pfam00553 713604021239 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604021240 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604021241 DNA binding residues [nucleotide binding] 713604021242 dimer interface [polypeptide binding]; other site 713604021243 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604021244 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604021245 Mg2+ binding site [ion binding]; other site 713604021246 G-X-G motif; other site 713604021247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604021248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604021249 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604021250 hypothetical protein; Provisional; Region: PRK07236 713604021251 hypothetical protein; Provisional; Region: PRK07588 713604021252 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604021253 mce related protein; Region: MCE; pfam02470 713604021254 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604021255 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604021256 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 713604021257 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604021258 Methyltransferase domain; Region: Methyltransf_11; pfam08241 713604021259 PAC2 family; Region: PAC2; pfam09754 713604021260 Uncharacterized conserved protein [Function unknown]; Region: COG3402 713604021261 Bacterial PH domain; Region: DUF304; pfam03703 713604021262 Bacterial PH domain; Region: DUF304; pfam03703 713604021263 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 713604021264 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604021265 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 713604021266 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604021267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604021268 Coenzyme A binding pocket [chemical binding]; other site 713604021269 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604021270 active site 713604021271 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604021272 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 713604021273 inhibitor-cofactor binding pocket; inhibition site 713604021274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021275 catalytic residue [active] 713604021276 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604021277 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604021278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604021279 putative DNA binding site [nucleotide binding]; other site 713604021280 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604021281 putative Zn2+ binding site [ion binding]; other site 713604021282 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604021283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604021284 DNA-binding site [nucleotide binding]; DNA binding site 713604021285 FCD domain; Region: FCD; pfam07729 713604021286 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 713604021287 classical (c) SDRs; Region: SDR_c; cd05233 713604021288 NAD(P) binding site [chemical binding]; other site 713604021289 active site 713604021290 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 713604021291 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 713604021292 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 713604021293 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 713604021294 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 713604021295 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 713604021296 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604021297 PYR/PP interface [polypeptide binding]; other site 713604021298 dimer interface [polypeptide binding]; other site 713604021299 TPP binding site [chemical binding]; other site 713604021300 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604021301 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 713604021302 TPP-binding site [chemical binding]; other site 713604021303 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 713604021304 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 713604021305 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 713604021306 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 713604021307 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 713604021308 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 713604021309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604021310 FeS/SAM binding site; other site 713604021311 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 713604021312 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 713604021313 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 713604021314 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604021315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604021316 proline racemase; Provisional; Region: PRK13969 713604021317 putative amidase; Provisional; Region: PRK06169 713604021318 Amidase; Region: Amidase; pfam01425 713604021319 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 713604021320 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 713604021321 NAD binding site [chemical binding]; other site 713604021322 ligand binding site [chemical binding]; other site 713604021323 catalytic site [active] 713604021324 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 713604021325 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 713604021326 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604021327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604021328 DNA-binding site [nucleotide binding]; DNA binding site 713604021329 FCD domain; Region: FCD; pfam07729 713604021330 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 713604021331 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 713604021332 tartrate dehydrogenase; Region: TTC; TIGR02089 713604021333 succinic semialdehyde dehydrogenase; Region: PLN02278 713604021334 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 713604021335 tetramerization interface [polypeptide binding]; other site 713604021336 NAD(P) binding site [chemical binding]; other site 713604021337 catalytic residues [active] 713604021338 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 713604021339 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604021340 inhibitor-cofactor binding pocket; inhibition site 713604021341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021342 catalytic residue [active] 713604021343 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 713604021344 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604021345 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604021346 active site 713604021347 catalytic tetrad [active] 713604021348 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604021349 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604021350 FAD binding domain; Region: FAD_binding_4; pfam01565 713604021351 hypothetical protein; Validated; Region: PRK07586 713604021352 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604021353 PYR/PP interface [polypeptide binding]; other site 713604021354 dimer interface [polypeptide binding]; other site 713604021355 TPP binding site [chemical binding]; other site 713604021356 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 713604021357 TPP-binding site [chemical binding]; other site 713604021358 dimer interface [polypeptide binding]; other site 713604021359 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604021360 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604021361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604021362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604021363 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 713604021364 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604021365 Histidine kinase; Region: HisKA_3; pfam07730 713604021366 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604021367 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604021368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604021369 active site 713604021370 phosphorylation site [posttranslational modification] 713604021371 intermolecular recognition site; other site 713604021372 dimerization interface [polypeptide binding]; other site 713604021373 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604021374 DNA binding residues [nucleotide binding] 713604021375 dimerization interface [polypeptide binding]; other site 713604021376 MMPL family; Region: MMPL; pfam03176 713604021377 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604021378 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604021379 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 713604021380 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604021381 substrate binding site [chemical binding]; other site 713604021382 oxyanion hole (OAH) forming residues; other site 713604021383 trimer interface [polypeptide binding]; other site 713604021384 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604021385 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604021386 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 713604021387 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604021388 dimer interface [polypeptide binding]; other site 713604021389 active site 713604021390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604021391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604021392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604021393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604021394 HEXXH motif domain; Region: mod_HExxH; TIGR04267 713604021395 TPR repeat; Region: TPR_11; pfam13414 713604021396 NB-ARC domain; Region: NB-ARC; pfam00931 713604021397 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604021398 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604021399 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604021400 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604021401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604021402 Walker A motif; other site 713604021403 ATP binding site [chemical binding]; other site 713604021404 Walker B motif; other site 713604021405 cyclase homology domain; Region: CHD; cd07302 713604021406 metal binding site [ion binding]; metal-binding site 713604021407 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 713604021408 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 713604021409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604021410 active site 713604021411 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604021412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604021413 active site 713604021414 putative transposase OrfB; Reviewed; Region: PHA02517 713604021415 HTH-like domain; Region: HTH_21; pfam13276 713604021416 Integrase core domain; Region: rve; pfam00665 713604021417 Integrase core domain; Region: rve_3; pfam13683 713604021418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604021419 Transposase; Region: HTH_Tnp_1; cl17663 713604021420 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604021421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604021422 non-specific DNA binding site [nucleotide binding]; other site 713604021423 salt bridge; other site 713604021424 sequence-specific DNA binding site [nucleotide binding]; other site 713604021425 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 713604021426 nudix motif; other site 713604021427 Uncharacterized conserved protein [Function unknown]; Region: COG1479 713604021428 Protein of unknown function DUF262; Region: DUF262; pfam03235 713604021429 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604021430 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 713604021431 short chain dehydrogenase; Provisional; Region: PRK06181 713604021432 classical (c) SDRs; Region: SDR_c; cd05233 713604021433 NAD(P) binding site [chemical binding]; other site 713604021434 active site 713604021435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604021436 Coenzyme A binding pocket [chemical binding]; other site 713604021437 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 713604021438 active site 713604021439 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 713604021440 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604021441 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604021442 active site 713604021443 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 713604021444 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604021445 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 713604021446 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 713604021447 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604021448 carboxyltransferase (CT) interaction site; other site 713604021449 biotinylation site [posttranslational modification]; other site 713604021450 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 713604021451 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604021452 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604021453 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 713604021454 active site 713604021455 oxyanion hole [active] 713604021456 catalytic triad [active] 713604021457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604021458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604021459 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 713604021460 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 713604021461 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 713604021462 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 713604021463 homodimer interface [polypeptide binding]; other site 713604021464 substrate-cofactor binding pocket; other site 713604021465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021466 catalytic residue [active] 713604021467 FAD binding domain; Region: FAD_binding_3; pfam01494 713604021468 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604021469 hypothetical protein; Provisional; Region: PRK07236 713604021470 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 713604021471 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604021472 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604021473 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604021474 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 713604021475 putative dimer interface [polypeptide binding]; other site 713604021476 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604021477 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604021478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604021479 S-adenosylmethionine binding site [chemical binding]; other site 713604021480 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604021481 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 713604021482 active site 713604021483 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604021484 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604021485 NAD(P) binding site [chemical binding]; other site 713604021486 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 713604021487 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 713604021488 hexamer interface [polypeptide binding]; other site 713604021489 ligand binding site [chemical binding]; other site 713604021490 putative active site [active] 713604021491 NAD(P) binding site [chemical binding]; other site 713604021492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604021493 ATP binding site [chemical binding]; other site 713604021494 G-X-G motif; other site 713604021495 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604021496 dimerization interface [polypeptide binding]; other site 713604021497 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604021498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604021499 active site 713604021500 dimerization interface [polypeptide binding]; other site 713604021501 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604021502 DNA binding site [nucleotide binding] 713604021503 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604021504 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 713604021505 Walker A/P-loop; other site 713604021506 ATP binding site [chemical binding]; other site 713604021507 Q-loop/lid; other site 713604021508 ABC transporter signature motif; other site 713604021509 Walker B; other site 713604021510 D-loop; other site 713604021511 H-loop/switch region; other site 713604021512 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 713604021513 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604021514 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604021515 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604021516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021517 Walker A/P-loop; other site 713604021518 ATP binding site [chemical binding]; other site 713604021519 Q-loop/lid; other site 713604021520 ABC transporter signature motif; other site 713604021521 Walker B; other site 713604021522 D-loop; other site 713604021523 H-loop/switch region; other site 713604021524 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604021525 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604021526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021527 Walker A/P-loop; other site 713604021528 ATP binding site [chemical binding]; other site 713604021529 Q-loop/lid; other site 713604021530 ABC transporter signature motif; other site 713604021531 Walker B; other site 713604021532 D-loop; other site 713604021533 H-loop/switch region; other site 713604021534 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 713604021535 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 713604021536 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 713604021537 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 713604021538 TPP-binding site [chemical binding]; other site 713604021539 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 713604021540 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604021541 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604021542 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604021543 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604021544 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604021545 active site 713604021546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604021547 Coenzyme A binding pocket [chemical binding]; other site 713604021548 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604021549 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604021550 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604021551 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 713604021552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021553 dimer interface [polypeptide binding]; other site 713604021554 ABC-ATPase subunit interface; other site 713604021555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021556 dimer interface [polypeptide binding]; other site 713604021557 conserved gate region; other site 713604021558 putative PBP binding loops; other site 713604021559 ABC-ATPase subunit interface; other site 713604021560 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 713604021561 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 713604021562 Walker A/P-loop; other site 713604021563 ATP binding site [chemical binding]; other site 713604021564 Q-loop/lid; other site 713604021565 ABC transporter signature motif; other site 713604021566 Walker B; other site 713604021567 D-loop; other site 713604021568 H-loop/switch region; other site 713604021569 Protein of unknown function DUF43; Region: DUF43; pfam01861 713604021570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604021571 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 713604021572 Malic enzyme, N-terminal domain; Region: malic; pfam00390 713604021573 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 713604021574 NAD(P) binding pocket [chemical binding]; other site 713604021575 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 713604021576 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604021577 hydrophobic ligand binding site; other site 713604021578 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604021579 CoenzymeA binding site [chemical binding]; other site 713604021580 subunit interaction site [polypeptide binding]; other site 713604021581 PHB binding site; other site 713604021582 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604021583 catalytic core [active] 713604021584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604021585 Coenzyme A binding pocket [chemical binding]; other site 713604021586 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 713604021587 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 713604021588 Transcription factor WhiB; Region: Whib; pfam02467 713604021589 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 713604021590 PAS fold; Region: PAS_4; pfam08448 713604021591 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 713604021592 Histidine kinase; Region: HisKA_2; pfam07568 713604021593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604021594 ATP binding site [chemical binding]; other site 713604021595 Mg2+ binding site [ion binding]; other site 713604021596 G-X-G motif; other site 713604021597 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 713604021598 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 713604021599 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604021600 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604021601 DNA binding residues [nucleotide binding] 713604021602 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 713604021603 putative deacylase active site [active] 713604021604 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 713604021605 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 713604021606 Predicted GTPases [General function prediction only]; Region: COG1162 713604021607 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 713604021608 GTPase/Zn-binding domain interface [polypeptide binding]; other site 713604021609 GTP/Mg2+ binding site [chemical binding]; other site 713604021610 G4 box; other site 713604021611 G5 box; other site 713604021612 G1 box; other site 713604021613 Switch I region; other site 713604021614 G2 box; other site 713604021615 G3 box; other site 713604021616 Switch II region; other site 713604021617 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 713604021618 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 713604021619 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 713604021620 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 713604021621 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 713604021622 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 713604021623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604021624 active site 713604021625 motif I; other site 713604021626 motif II; other site 713604021627 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604021628 Cytochrome P450; Region: p450; cl12078 713604021629 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 713604021630 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 713604021631 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 713604021632 30S subunit binding site; other site 713604021633 lipoprotein LpqB; Provisional; Region: PRK13615 713604021634 Sporulation and spore germination; Region: Germane; pfam10646 713604021635 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 713604021636 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 713604021637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604021638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604021639 dimer interface [polypeptide binding]; other site 713604021640 phosphorylation site [posttranslational modification] 713604021641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604021642 ATP binding site [chemical binding]; other site 713604021643 Mg2+ binding site [ion binding]; other site 713604021644 G-X-G motif; other site 713604021645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604021646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604021647 active site 713604021648 phosphorylation site [posttranslational modification] 713604021649 intermolecular recognition site; other site 713604021650 dimerization interface [polypeptide binding]; other site 713604021651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604021652 DNA binding site [nucleotide binding] 713604021653 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 713604021654 [2Fe-2S] cluster binding site [ion binding]; other site 713604021655 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604021656 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604021657 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604021658 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604021659 HTH domain; Region: HTH_11; pfam08279 713604021660 WYL domain; Region: WYL; pfam13280 713604021661 FAD dependent oxidoreductase; Region: DAO; pfam01266 713604021662 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604021663 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 713604021664 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 713604021665 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 713604021666 thymidylate kinase; Validated; Region: PRK07933 713604021667 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 713604021668 putative active site [active] 713604021669 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 713604021670 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 713604021671 putative active site [active] 713604021672 HicB family; Region: HicB; pfam05534 713604021673 Adenosylhomocysteinase; Provisional; Region: PTZ00075 713604021674 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 713604021675 homotetramer interface [polypeptide binding]; other site 713604021676 ligand binding site [chemical binding]; other site 713604021677 catalytic site [active] 713604021678 NAD binding site [chemical binding]; other site 713604021679 amino acid transporter; Region: 2A0306; TIGR00909 713604021680 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 713604021681 Cation efflux family; Region: Cation_efflux; pfam01545 713604021682 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604021683 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604021684 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 713604021685 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 713604021686 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 713604021687 Trm112p-like protein; Region: Trm112p; cl01066 713604021688 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 713604021689 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 713604021690 active site 713604021691 substrate binding site [chemical binding]; other site 713604021692 metal binding site [ion binding]; metal-binding site 713604021693 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 713604021694 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 713604021695 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604021696 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604021697 active site 713604021698 Transcription factor WhiB; Region: Whib; pfam02467 713604021699 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 713604021700 active site 713604021701 putative substrate binding region [chemical binding]; other site 713604021702 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 713604021703 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 713604021704 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604021705 Walker A/P-loop; other site 713604021706 ATP binding site [chemical binding]; other site 713604021707 Q-loop/lid; other site 713604021708 ABC transporter signature motif; other site 713604021709 Walker B; other site 713604021710 D-loop; other site 713604021711 H-loop/switch region; other site 713604021712 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604021713 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604021714 Walker A/P-loop; other site 713604021715 ATP binding site [chemical binding]; other site 713604021716 Q-loop/lid; other site 713604021717 ABC transporter signature motif; other site 713604021718 Walker B; other site 713604021719 D-loop; other site 713604021720 H-loop/switch region; other site 713604021721 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604021722 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604021723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021724 dimer interface [polypeptide binding]; other site 713604021725 conserved gate region; other site 713604021726 putative PBP binding loops; other site 713604021727 ABC-ATPase subunit interface; other site 713604021728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604021729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021730 dimer interface [polypeptide binding]; other site 713604021731 conserved gate region; other site 713604021732 putative PBP binding loops; other site 713604021733 ABC-ATPase subunit interface; other site 713604021734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604021735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021736 putative PBP binding loops; other site 713604021737 dimer interface [polypeptide binding]; other site 713604021738 ABC-ATPase subunit interface; other site 713604021739 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 713604021740 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 713604021741 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 713604021742 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 713604021743 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 713604021744 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 713604021745 G1 box; other site 713604021746 putative GEF interaction site [polypeptide binding]; other site 713604021747 GTP/Mg2+ binding site [chemical binding]; other site 713604021748 Switch I region; other site 713604021749 G2 box; other site 713604021750 G3 box; other site 713604021751 Switch II region; other site 713604021752 G4 box; other site 713604021753 G5 box; other site 713604021754 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 713604021755 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 713604021756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 713604021757 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 713604021758 active site 713604021759 HIGH motif; other site 713604021760 dimer interface [polypeptide binding]; other site 713604021761 KMSKS motif; other site 713604021762 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 713604021763 nudix motif; other site 713604021764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604021765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604021766 dimer interface [polypeptide binding]; other site 713604021767 phosphorylation site [posttranslational modification] 713604021768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604021769 ATP binding site [chemical binding]; other site 713604021770 Mg2+ binding site [ion binding]; other site 713604021771 G-X-G motif; other site 713604021772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604021773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604021774 active site 713604021775 phosphorylation site [posttranslational modification] 713604021776 intermolecular recognition site; other site 713604021777 dimerization interface [polypeptide binding]; other site 713604021778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604021779 DNA binding site [nucleotide binding] 713604021780 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 713604021781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021782 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604021783 Walker A/P-loop; other site 713604021784 ATP binding site [chemical binding]; other site 713604021785 Q-loop/lid; other site 713604021786 ABC transporter signature motif; other site 713604021787 Walker B; other site 713604021788 D-loop; other site 713604021789 H-loop/switch region; other site 713604021790 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 713604021791 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 713604021792 Walker A/P-loop; other site 713604021793 ATP binding site [chemical binding]; other site 713604021794 Q-loop/lid; other site 713604021795 ABC transporter signature motif; other site 713604021796 Walker B; other site 713604021797 D-loop; other site 713604021798 H-loop/switch region; other site 713604021799 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 713604021800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604021801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021802 dimer interface [polypeptide binding]; other site 713604021803 conserved gate region; other site 713604021804 putative PBP binding loops; other site 713604021805 ABC-ATPase subunit interface; other site 713604021806 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 713604021807 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604021808 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 713604021809 aromatic arch; other site 713604021810 DCoH dimer interaction site [polypeptide binding]; other site 713604021811 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 713604021812 DCoH tetramer interaction site [polypeptide binding]; other site 713604021813 substrate binding site [chemical binding]; other site 713604021814 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 713604021815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604021816 putative DNA binding site [nucleotide binding]; other site 713604021817 putative Zn2+ binding site [ion binding]; other site 713604021818 GTP-binding protein YchF; Reviewed; Region: PRK09601 713604021819 YchF GTPase; Region: YchF; cd01900 713604021820 G1 box; other site 713604021821 GTP/Mg2+ binding site [chemical binding]; other site 713604021822 Switch I region; other site 713604021823 G2 box; other site 713604021824 Switch II region; other site 713604021825 G3 box; other site 713604021826 G4 box; other site 713604021827 G5 box; other site 713604021828 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 713604021829 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 713604021830 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 713604021831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604021832 AlkA N-terminal domain; Region: AlkA_N; pfam06029 713604021833 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 713604021834 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 713604021835 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 713604021836 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 713604021837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021838 Walker A/P-loop; other site 713604021839 ATP binding site [chemical binding]; other site 713604021840 Q-loop/lid; other site 713604021841 ABC transporter signature motif; other site 713604021842 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 713604021843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021844 Walker B; other site 713604021845 D-loop; other site 713604021846 H-loop/switch region; other site 713604021847 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 713604021848 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604021849 active site 713604021850 metal binding site [ion binding]; metal-binding site 713604021851 DNA binding site [nucleotide binding] 713604021852 RmuC family; Region: RmuC; pfam02646 713604021853 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 713604021854 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 713604021855 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 713604021856 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 713604021857 generic binding surface II; other site 713604021858 generic binding surface I; other site 713604021859 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 713604021860 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 713604021861 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 713604021862 putative active site [active] 713604021863 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 713604021864 active site 713604021865 substrate binding sites [chemical binding]; other site 713604021866 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 713604021867 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604021868 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604021869 fumarate hydratase; Reviewed; Region: fumC; PRK00485 713604021870 Class II fumarases; Region: Fumarase_classII; cd01362 713604021871 active site 713604021872 tetramer interface [polypeptide binding]; other site 713604021873 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604021874 salt bridge; other site 713604021875 non-specific DNA binding site [nucleotide binding]; other site 713604021876 sequence-specific DNA binding site [nucleotide binding]; other site 713604021877 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 713604021878 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 713604021879 active site 713604021880 DNA binding site [nucleotide binding] 713604021881 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 713604021882 DNA binding site [nucleotide binding] 713604021883 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604021884 Domain of unknown function (DUF309); Region: DUF309; pfam03745 713604021885 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 713604021886 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 713604021887 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604021888 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604021889 phosphate binding site [ion binding]; other site 713604021890 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604021891 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 713604021892 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 713604021893 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604021894 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 713604021895 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604021896 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604021897 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604021898 active site 713604021899 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 713604021900 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 713604021901 putative active site [active] 713604021902 PhoH-like protein; Region: PhoH; pfam02562 713604021903 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 713604021904 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 713604021905 catalytic residue [active] 713604021906 putative FPP diphosphate binding site; other site 713604021907 putative FPP binding hydrophobic cleft; other site 713604021908 dimer interface [polypeptide binding]; other site 713604021909 putative IPP diphosphate binding site; other site 713604021910 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 713604021911 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 713604021912 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604021913 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 713604021914 PRC-barrel domain; Region: PRC; pfam05239 713604021915 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 713604021916 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604021917 acyl-coenzyme A oxidase; Region: PLN02636 713604021918 active site 713604021919 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 713604021920 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 713604021921 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 713604021922 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 713604021923 catalytic residues [active] 713604021924 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 713604021925 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 713604021926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604021927 S-adenosylmethionine binding site [chemical binding]; other site 713604021928 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 713604021929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021930 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 713604021931 active site 713604021932 Walker A/P-loop; other site 713604021933 ATP binding site [chemical binding]; other site 713604021934 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 713604021935 active site 713604021936 metal binding site [ion binding]; metal-binding site 713604021937 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 713604021938 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 713604021939 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 713604021940 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 713604021941 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 713604021942 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604021943 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 713604021944 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604021945 AsnC family; Region: AsnC_trans_reg; pfam01037 713604021946 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 713604021947 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 713604021948 dimer interface [polypeptide binding]; other site 713604021949 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 713604021950 active site 713604021951 Fe binding site [ion binding]; other site 713604021952 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 713604021953 threonine dehydratase; Provisional; Region: PRK08198 713604021954 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 713604021955 tetramer interface [polypeptide binding]; other site 713604021956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021957 catalytic residue [active] 713604021958 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 713604021959 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604021960 cystathionine gamma-synthase; Provisional; Region: PRK07811 713604021961 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 713604021962 homodimer interface [polypeptide binding]; other site 713604021963 substrate-cofactor binding pocket; other site 713604021964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021965 catalytic residue [active] 713604021966 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 713604021967 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604021968 dimer interface [polypeptide binding]; other site 713604021969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021970 catalytic residue [active] 713604021971 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 713604021972 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 713604021973 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604021974 dimer interface [polypeptide binding]; other site 713604021975 active site 713604021976 Bax inhibitor 1 like; Region: BaxI_1; cl17691 713604021977 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604021978 active site 713604021979 putative catalytic site [active] 713604021980 short chain dehydrogenase; Provisional; Region: PRK07201 713604021981 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 713604021982 putative NAD(P) binding site [chemical binding]; other site 713604021983 active site 713604021984 putative substrate binding site [chemical binding]; other site 713604021985 classical (c) SDRs; Region: SDR_c; cd05233 713604021986 NAD(P) binding site [chemical binding]; other site 713604021987 active site 713604021988 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 713604021989 amidase; Provisional; Region: PRK12470 713604021990 Amidase; Region: Amidase; cl11426 713604021991 Amidase; Region: Amidase; cl11426 713604021992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604021993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604021994 DNA binding residues [nucleotide binding] 713604021995 dimerization interface [polypeptide binding]; other site 713604021996 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 713604021997 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604021998 DNA binding site [nucleotide binding] 713604021999 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604022000 AAA ATPase domain; Region: AAA_16; pfam13191 713604022001 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604022002 DNA binding site [nucleotide binding] 713604022003 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604022004 AAA ATPase domain; Region: AAA_16; pfam13191 713604022005 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604022006 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604022007 DNA binding residues [nucleotide binding] 713604022008 dimerization interface [polypeptide binding]; other site 713604022009 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604022010 beta-galactosidase; Region: BGL; TIGR03356 713604022011 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604022012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022013 dimer interface [polypeptide binding]; other site 713604022014 conserved gate region; other site 713604022015 putative PBP binding loops; other site 713604022016 ABC-ATPase subunit interface; other site 713604022017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022018 dimer interface [polypeptide binding]; other site 713604022019 putative PBP binding loops; other site 713604022020 ABC-ATPase subunit interface; other site 713604022021 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604022022 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604022023 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604022024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604022025 DNA binding residues [nucleotide binding] 713604022026 dimerization interface [polypeptide binding]; other site 713604022027 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604022028 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 713604022029 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604022030 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604022031 active site 713604022032 catalytic tetrad [active] 713604022033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604022034 putative substrate translocation pore; other site 713604022035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604022036 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604022037 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604022038 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604022039 AsnC family; Region: AsnC_trans_reg; pfam01037 713604022040 Putative zinc-finger; Region: zf-HC2; pfam13490 713604022041 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 713604022042 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604022043 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 713604022044 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604022045 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 713604022046 putative sugar binding site [chemical binding]; other site 713604022047 catalytic residues [active] 713604022048 Thioesterase domain; Region: Thioesterase; pfam00975 713604022049 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 713604022050 active site 713604022051 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 713604022052 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604022053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604022054 TQXA domain; Region: TQXA_dom; TIGR03934 713604022055 Cellulose binding domain; Region: CBM_2; pfam00553 713604022056 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604022057 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 713604022058 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604022059 G1 box; other site 713604022060 GTP/Mg2+ binding site [chemical binding]; other site 713604022061 G2 box; other site 713604022062 Switch I region; other site 713604022063 G3 box; other site 713604022064 Switch II region; other site 713604022065 G4 box; other site 713604022066 G5 box; other site 713604022067 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 713604022068 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 713604022069 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 713604022070 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 713604022071 Phosphotransferase enzyme family; Region: APH; pfam01636 713604022072 putative active site [active] 713604022073 putative substrate binding site [chemical binding]; other site 713604022074 ATP binding site [chemical binding]; other site 713604022075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604022076 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604022077 dimerization interface [polypeptide binding]; other site 713604022078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604022079 dimer interface [polypeptide binding]; other site 713604022080 phosphorylation site [posttranslational modification] 713604022081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022082 ATP binding site [chemical binding]; other site 713604022083 Mg2+ binding site [ion binding]; other site 713604022084 G-X-G motif; other site 713604022085 enolase; Provisional; Region: eno; PRK00077 713604022086 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 713604022087 dimer interface [polypeptide binding]; other site 713604022088 metal binding site [ion binding]; metal-binding site 713604022089 substrate binding pocket [chemical binding]; other site 713604022090 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 713604022091 Catalytic site [active] 713604022092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604022093 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604022094 Walker A/P-loop; other site 713604022095 ATP binding site [chemical binding]; other site 713604022096 Q-loop/lid; other site 713604022097 ABC transporter signature motif; other site 713604022098 Walker B; other site 713604022099 D-loop; other site 713604022100 H-loop/switch region; other site 713604022101 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604022102 AAA ATPase domain; Region: AAA_16; pfam13191 713604022103 AAA domain; Region: AAA_22; pfam13401 713604022104 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604022105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604022106 TPR motif; other site 713604022107 binding surface 713604022108 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604022109 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604022110 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 713604022111 active site 713604022112 catalytic triad [active] 713604022113 oxyanion hole [active] 713604022114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 713604022115 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604022116 Predicted ATPase [General function prediction only]; Region: COG3903 713604022117 hypothetical protein; Provisional; Region: PRK06834 713604022118 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604022119 AAA ATPase domain; Region: AAA_16; pfam13191 713604022120 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604022121 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604022122 DNA binding residues [nucleotide binding] 713604022123 dimerization interface [polypeptide binding]; other site 713604022124 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 713604022125 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 713604022126 AAA ATPase domain; Region: AAA_16; pfam13191 713604022127 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 713604022128 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 713604022129 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 713604022130 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604022131 TIR domain; Region: TIR_2; pfam13676 713604022132 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604022133 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 713604022134 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 713604022135 HEXXH motif domain; Region: mod_HExxH; TIGR04267 713604022136 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604022137 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604022138 DNA binding residues [nucleotide binding] 713604022139 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604022140 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604022141 active site 713604022142 ATP binding site [chemical binding]; other site 713604022143 substrate binding site [chemical binding]; other site 713604022144 activation loop (A-loop); other site 713604022145 PemK-like protein; Region: PemK; pfam02452 713604022146 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604022147 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604022148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022150 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604022151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604022152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604022153 DNA binding residues [nucleotide binding] 713604022154 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 713604022155 active site 713604022156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604022157 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604022158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604022159 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 713604022160 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 713604022161 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 713604022162 nudix motif; other site 713604022163 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 713604022164 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 713604022165 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604022166 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 713604022167 Fe-S cluster binding site [ion binding]; other site 713604022168 DNA binding site [nucleotide binding] 713604022169 active site 713604022170 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 713604022171 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 713604022172 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 713604022173 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604022174 active site 713604022175 catalytic residues [active] 713604022176 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604022177 catalytic residues [active] 713604022178 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 713604022179 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604022180 Walker A/P-loop; other site 713604022181 ATP binding site [chemical binding]; other site 713604022182 Q-loop/lid; other site 713604022183 ABC transporter signature motif; other site 713604022184 Walker B; other site 713604022185 D-loop; other site 713604022186 H-loop/switch region; other site 713604022187 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 713604022188 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604022189 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604022190 Walker A/P-loop; other site 713604022191 ATP binding site [chemical binding]; other site 713604022192 Q-loop/lid; other site 713604022193 ABC transporter signature motif; other site 713604022194 Walker B; other site 713604022195 D-loop; other site 713604022196 H-loop/switch region; other site 713604022197 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 713604022198 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 713604022199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022200 dimer interface [polypeptide binding]; other site 713604022201 conserved gate region; other site 713604022202 putative PBP binding loops; other site 713604022203 ABC-ATPase subunit interface; other site 713604022204 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604022205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022206 dimer interface [polypeptide binding]; other site 713604022207 conserved gate region; other site 713604022208 putative PBP binding loops; other site 713604022209 ABC-ATPase subunit interface; other site 713604022210 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 713604022211 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 713604022212 exopolyphosphatase; Region: exo_poly_only; TIGR03706 713604022213 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 713604022214 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604022215 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604022216 Protein of unknown function (DUF501); Region: DUF501; cl00652 713604022217 Septum formation initiator; Region: DivIC; cl17659 713604022218 enolase; Provisional; Region: eno; PRK00077 713604022219 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 713604022220 dimer interface [polypeptide binding]; other site 713604022221 metal binding site [ion binding]; metal-binding site 713604022222 substrate binding pocket [chemical binding]; other site 713604022223 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 713604022224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604022225 binding surface 713604022226 TPR motif; other site 713604022227 TPR repeat; Region: TPR_11; pfam13414 713604022228 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 713604022229 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604022230 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604022231 Iron permease FTR1 family; Region: FTR1; cl00475 713604022232 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 713604022233 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 713604022234 Imelysin; Region: Peptidase_M75; pfam09375 713604022235 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 713604022236 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 713604022237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022238 WHG domain; Region: WHG; pfam13305 713604022239 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 713604022240 active site 713604022241 catalytic triad [active] 713604022242 oxyanion hole [active] 713604022243 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 713604022244 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 713604022245 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 713604022246 Walker A/P-loop; other site 713604022247 ATP binding site [chemical binding]; other site 713604022248 Q-loop/lid; other site 713604022249 ABC transporter signature motif; other site 713604022250 Walker B; other site 713604022251 D-loop; other site 713604022252 H-loop/switch region; other site 713604022253 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604022254 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604022255 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 713604022256 homodimer interface [polypeptide binding]; other site 713604022257 MazG family protein; Region: mazG; TIGR00444 713604022258 metal binding site [ion binding]; metal-binding site 713604022259 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 713604022260 SurA N-terminal domain; Region: SurA_N_3; cl07813 713604022261 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 713604022262 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 713604022263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604022264 ATP binding site [chemical binding]; other site 713604022265 putative Mg++ binding site [ion binding]; other site 713604022266 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604022267 nucleotide binding region [chemical binding]; other site 713604022268 ATP-binding site [chemical binding]; other site 713604022269 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 713604022270 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 713604022271 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604022272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604022273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604022274 non-specific DNA binding site [nucleotide binding]; other site 713604022275 salt bridge; other site 713604022276 sequence-specific DNA binding site [nucleotide binding]; other site 713604022277 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604022278 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604022279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604022280 S-adenosylmethionine binding site [chemical binding]; other site 713604022281 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604022282 Histidine kinase; Region: HisKA_3; pfam07730 713604022283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022284 ATP binding site [chemical binding]; other site 713604022285 Mg2+ binding site [ion binding]; other site 713604022286 G-X-G motif; other site 713604022287 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604022288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022289 active site 713604022290 phosphorylation site [posttranslational modification] 713604022291 intermolecular recognition site; other site 713604022292 dimerization interface [polypeptide binding]; other site 713604022293 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604022294 DNA binding residues [nucleotide binding] 713604022295 dimerization interface [polypeptide binding]; other site 713604022296 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604022297 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604022298 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 713604022299 classical (c) SDRs; Region: SDR_c; cd05233 713604022300 NAD(P) binding site [chemical binding]; other site 713604022301 active site 713604022302 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 713604022303 Isochorismatase family; Region: Isochorismatase; pfam00857 713604022304 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 713604022305 catalytic triad [active] 713604022306 conserved cis-peptide bond; other site 713604022307 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 713604022308 nudix motif; other site 713604022309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022311 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604022312 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604022313 Di-iron ligands [ion binding]; other site 713604022314 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604022315 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604022316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604022317 metal binding site [ion binding]; metal-binding site 713604022318 active site 713604022319 I-site; other site 713604022320 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 713604022321 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 713604022322 Substrate binding site; other site 713604022323 Mg++ binding site; other site 713604022324 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 713604022325 active site 713604022326 substrate binding site [chemical binding]; other site 713604022327 CoA binding site [chemical binding]; other site 713604022328 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 713604022329 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 713604022330 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604022331 active site 713604022332 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604022333 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604022334 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 713604022335 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604022336 NAD binding site [chemical binding]; other site 713604022337 substrate binding site [chemical binding]; other site 713604022338 putative active site [active] 713604022339 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 713604022340 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 713604022341 5S rRNA interface [nucleotide binding]; other site 713604022342 CTC domain interface [polypeptide binding]; other site 713604022343 L16 interface [polypeptide binding]; other site 713604022344 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 713604022345 putative active site [active] 713604022346 catalytic residue [active] 713604022347 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604022348 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604022349 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604022350 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604022351 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 713604022352 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604022353 acyl-activating enzyme (AAE) consensus motif; other site 713604022354 active site 713604022355 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 713604022356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604022357 ABC transporter; Region: ABC_tran_2; pfam12848 713604022358 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604022359 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 713604022360 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 713604022361 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 713604022362 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 713604022363 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 713604022364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604022365 Walker A/P-loop; other site 713604022366 ATP binding site [chemical binding]; other site 713604022367 Q-loop/lid; other site 713604022368 ABC transporter signature motif; other site 713604022369 Walker B; other site 713604022370 D-loop; other site 713604022371 H-loop/switch region; other site 713604022372 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 713604022373 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 713604022374 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 713604022375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 713604022376 Domain of unknown function (DUF348); Region: DUF348; pfam03990 713604022377 G5 domain; Region: G5; pfam07501 713604022378 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 713604022379 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 713604022380 active site 713604022381 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 713604022382 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 713604022383 active site 713604022384 HIGH motif; other site 713604022385 KMSKS motif; other site 713604022386 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 713604022387 tRNA binding surface [nucleotide binding]; other site 713604022388 anticodon binding site; other site 713604022389 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604022390 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604022391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604022392 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604022393 Walker A/P-loop; other site 713604022394 ATP binding site [chemical binding]; other site 713604022395 Q-loop/lid; other site 713604022396 ABC transporter signature motif; other site 713604022397 Walker B; other site 713604022398 D-loop; other site 713604022399 H-loop/switch region; other site 713604022400 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604022401 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604022402 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 713604022403 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604022404 active site 713604022405 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 713604022406 chorismate binding enzyme; Region: Chorismate_bind; cl10555 713604022407 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604022408 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604022409 NAD(P) binding site [chemical binding]; other site 713604022410 Predicted methyltransferases [General function prediction only]; Region: COG0313 713604022411 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 713604022412 putative SAM binding site [chemical binding]; other site 713604022413 putative homodimer interface [polypeptide binding]; other site 713604022414 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 713604022415 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 713604022416 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604022417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604022418 S-adenosylmethionine binding site [chemical binding]; other site 713604022419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604022420 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604022421 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604022422 active site 713604022423 ATP binding site [chemical binding]; other site 713604022424 substrate binding site [chemical binding]; other site 713604022425 activation loop (A-loop); other site 713604022426 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 713604022427 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 713604022428 acyl-activating enzyme (AAE) consensus motif; other site 713604022429 putative AMP binding site [chemical binding]; other site 713604022430 putative active site [active] 713604022431 putative CoA binding site [chemical binding]; other site 713604022432 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 713604022433 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 713604022434 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 713604022435 active site 713604022436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 713604022438 MOSC domain; Region: MOSC; pfam03473 713604022439 hypothetical protein; Provisional; Region: PRK07079 713604022440 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 713604022441 metal binding site [ion binding]; metal-binding site 713604022442 putative dimer interface [polypeptide binding]; other site 713604022443 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604022444 Predicted flavoprotein [General function prediction only]; Region: COG0431 713604022445 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 713604022446 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604022447 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604022448 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604022449 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604022450 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 713604022451 active site 713604022452 catalytic triad [active] 713604022453 oxyanion hole [active] 713604022454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022455 WHG domain; Region: WHG; pfam13305 713604022456 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 713604022457 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604022458 putative DNA binding site [nucleotide binding]; other site 713604022459 dimerization interface [polypeptide binding]; other site 713604022460 putative Zn2+ binding site [ion binding]; other site 713604022461 MMPL family; Region: MMPL; pfam03176 713604022462 EamA-like transporter family; Region: EamA; pfam00892 713604022463 PAS domain S-box; Region: sensory_box; TIGR00229 713604022464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604022465 putative active site [active] 713604022466 heme pocket [chemical binding]; other site 713604022467 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604022468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604022469 metal binding site [ion binding]; metal-binding site 713604022470 active site 713604022471 I-site; other site 713604022472 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604022473 Cytochrome P450; Region: p450; pfam00067 713604022474 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604022475 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 713604022476 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604022477 P-loop; other site 713604022478 Magnesium ion binding site [ion binding]; other site 713604022479 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604022480 Magnesium ion binding site [ion binding]; other site 713604022481 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604022482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604022483 NmrA-like family; Region: NmrA; pfam05368 713604022484 NAD(P) binding site [chemical binding]; other site 713604022485 active site 713604022486 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 713604022487 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604022488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022489 active site 713604022490 phosphorylation site [posttranslational modification] 713604022491 intermolecular recognition site; other site 713604022492 dimerization interface [polypeptide binding]; other site 713604022493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604022494 DNA binding site [nucleotide binding] 713604022495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604022496 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604022497 dimerization interface [polypeptide binding]; other site 713604022498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604022499 dimer interface [polypeptide binding]; other site 713604022500 phosphorylation site [posttranslational modification] 713604022501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022502 ATP binding site [chemical binding]; other site 713604022503 Mg2+ binding site [ion binding]; other site 713604022504 G-X-G motif; other site 713604022505 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 713604022506 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 713604022507 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 713604022508 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 713604022509 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 713604022510 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 713604022511 NAD binding site [chemical binding]; other site 713604022512 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 713604022513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604022514 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604022515 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604022516 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 713604022517 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604022518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604022519 homodimer interface [polypeptide binding]; other site 713604022520 catalytic residue [active] 713604022521 Condensation domain; Region: Condensation; pfam00668 713604022522 Nonribosomal peptide synthase; Region: NRPS; pfam08415 713604022523 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 713604022524 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604022525 acyl-activating enzyme (AAE) consensus motif; other site 713604022526 AMP binding site [chemical binding]; other site 713604022527 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604022528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604022529 S-adenosylmethionine binding site [chemical binding]; other site 713604022530 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604022531 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604022532 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604022533 Thioesterase domain; Region: Thioesterase; pfam00975 713604022534 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604022535 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604022536 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604022537 active site 713604022538 ATP binding site [chemical binding]; other site 713604022539 substrate binding site [chemical binding]; other site 713604022540 activation loop (A-loop); other site 713604022541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604022542 binding surface 713604022543 TPR motif; other site 713604022544 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604022545 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 713604022546 DNA-binding interface [nucleotide binding]; DNA binding site 713604022547 AIPR protein; Region: AIPR; pfam10592 713604022548 AAA ATPase domain; Region: AAA_16; pfam13191 713604022549 Domain of unknown function DUF87; Region: DUF87; pfam01935 713604022550 AAA-like domain; Region: AAA_10; pfam12846 713604022551 Zonular occludens toxin (Zot); Region: Zot; cl17485 713604022552 DEAD-like helicases superfamily; Region: DEXDc; smart00487 713604022553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604022554 ATP binding site [chemical binding]; other site 713604022555 putative Mg++ binding site [ion binding]; other site 713604022556 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 713604022557 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 713604022558 GH3 auxin-responsive promoter; Region: GH3; pfam03321 713604022559 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 713604022560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604022561 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604022562 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 713604022563 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 713604022564 dimer interface [polypeptide binding]; other site 713604022565 putative functional site; other site 713604022566 putative MPT binding site; other site 713604022567 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 713604022568 active site 713604022569 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 713604022570 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 713604022571 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 713604022572 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 713604022573 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 713604022574 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 713604022575 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 713604022576 MPT binding site; other site 713604022577 trimer interface [polypeptide binding]; other site 713604022578 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604022579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604022580 NAD(P) binding site [chemical binding]; other site 713604022581 active site 713604022582 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 713604022583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604022584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604022585 dimer interface [polypeptide binding]; other site 713604022586 phosphorylation site [posttranslational modification] 713604022587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022588 ATP binding site [chemical binding]; other site 713604022589 Mg2+ binding site [ion binding]; other site 713604022590 G-X-G motif; other site 713604022591 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604022592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022593 active site 713604022594 phosphorylation site [posttranslational modification] 713604022595 intermolecular recognition site; other site 713604022596 dimerization interface [polypeptide binding]; other site 713604022597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604022598 DNA binding site [nucleotide binding] 713604022599 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 713604022600 Ligand binding site; other site 713604022601 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 713604022602 Putative Catalytic site; other site 713604022603 DXD motif; other site 713604022604 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 713604022605 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 713604022606 Moco binding site; other site 713604022607 metal coordination site [ion binding]; other site 713604022608 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 713604022609 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604022610 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604022611 protein binding site [polypeptide binding]; other site 713604022612 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 713604022613 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 713604022614 dimer interface [polypeptide binding]; other site 713604022615 active site 713604022616 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604022617 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 713604022618 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604022619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604022620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604022621 dimerization interface [polypeptide binding]; other site 713604022622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604022623 dimer interface [polypeptide binding]; other site 713604022624 phosphorylation site [posttranslational modification] 713604022625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022626 ATP binding site [chemical binding]; other site 713604022627 Mg2+ binding site [ion binding]; other site 713604022628 G-X-G motif; other site 713604022629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604022630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022631 active site 713604022632 phosphorylation site [posttranslational modification] 713604022633 intermolecular recognition site; other site 713604022634 dimerization interface [polypeptide binding]; other site 713604022635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604022636 DNA binding site [nucleotide binding] 713604022637 Predicted membrane protein [Function unknown]; Region: COG2860 713604022638 UPF0126 domain; Region: UPF0126; pfam03458 713604022639 UPF0126 domain; Region: UPF0126; pfam03458 713604022640 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604022641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022642 active site 713604022643 phosphorylation site [posttranslational modification] 713604022644 intermolecular recognition site; other site 713604022645 dimerization interface [polypeptide binding]; other site 713604022646 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604022647 DNA binding residues [nucleotide binding] 713604022648 dimerization interface [polypeptide binding]; other site 713604022649 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604022650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604022651 S-adenosylmethionine binding site [chemical binding]; other site 713604022652 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604022653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604022654 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604022655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604022656 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 713604022657 dimerization interface [polypeptide binding]; other site 713604022658 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604022659 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604022660 active site 713604022661 catalytic tetrad [active] 713604022662 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604022663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604022664 DNA-binding site [nucleotide binding]; DNA binding site 713604022665 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604022666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604022667 homodimer interface [polypeptide binding]; other site 713604022668 catalytic residue [active] 713604022669 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604022670 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604022671 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604022672 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604022673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604022674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604022675 active site 713604022676 ATP binding site [chemical binding]; other site 713604022677 substrate binding site [chemical binding]; other site 713604022678 activation loop (A-loop); other site 713604022679 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 713604022680 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 713604022681 active site 713604022682 dimerization interface [polypeptide binding]; other site 713604022683 Creatinine amidohydrolase; Region: Creatininase; pfam02633 713604022684 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 713604022685 dimerization interface [polypeptide binding]; other site 713604022686 active site 713604022687 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 713604022688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604022689 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604022690 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604022691 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 713604022692 active site 713604022693 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 713604022694 putative NAD(P) binding site [chemical binding]; other site 713604022695 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604022696 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 713604022697 nucleotide binding site [chemical binding]; other site 713604022698 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 713604022699 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 713604022700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604022701 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 713604022702 putative dimerization interface [polypeptide binding]; other site 713604022703 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604022704 FAD binding domain; Region: FAD_binding_4; pfam01565 713604022705 Berberine and berberine like; Region: BBE; pfam08031 713604022706 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 713604022707 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604022708 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604022709 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604022710 putative Zn2+ binding site [ion binding]; other site 713604022711 putative DNA binding site [nucleotide binding]; other site 713604022712 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 713604022713 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604022714 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604022715 PaaX-like protein; Region: PaaX; pfam07848 713604022716 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 713604022717 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 713604022718 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 713604022719 homotrimer interaction site [polypeptide binding]; other site 713604022720 putative active site [active] 713604022721 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 713604022722 hypothetical protein; Provisional; Region: PRK07236 713604022723 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 713604022724 active site 713604022725 FMN binding site [chemical binding]; other site 713604022726 substrate binding site [chemical binding]; other site 713604022727 homotetramer interface [polypeptide binding]; other site 713604022728 catalytic residue [active] 713604022729 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604022730 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604022731 active site 713604022732 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 713604022733 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604022734 beta-galactosidase; Region: BGL; TIGR03356 713604022735 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604022736 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604022737 Walker A/P-loop; other site 713604022738 ATP binding site [chemical binding]; other site 713604022739 Q-loop/lid; other site 713604022740 ABC transporter signature motif; other site 713604022741 Walker B; other site 713604022742 D-loop; other site 713604022743 H-loop/switch region; other site 713604022744 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604022745 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604022746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022747 dimer interface [polypeptide binding]; other site 713604022748 conserved gate region; other site 713604022749 putative PBP binding loops; other site 713604022750 ABC-ATPase subunit interface; other site 713604022751 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604022752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022753 dimer interface [polypeptide binding]; other site 713604022754 conserved gate region; other site 713604022755 putative PBP binding loops; other site 713604022756 ABC-ATPase subunit interface; other site 713604022757 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604022758 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604022759 Walker A/P-loop; other site 713604022760 ATP binding site [chemical binding]; other site 713604022761 Q-loop/lid; other site 713604022762 ABC transporter signature motif; other site 713604022763 Walker B; other site 713604022764 D-loop; other site 713604022765 H-loop/switch region; other site 713604022766 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604022767 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 713604022768 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 713604022769 substrate binding site [chemical binding]; other site 713604022770 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 713604022771 putative switch regulator; other site 713604022772 non-specific DNA interactions [nucleotide binding]; other site 713604022773 DNA binding site [nucleotide binding] 713604022774 sequence specific DNA binding site [nucleotide binding]; other site 713604022775 putative cAMP binding site [chemical binding]; other site 713604022776 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604022777 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604022778 nucleotide binding site [chemical binding]; other site 713604022779 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 713604022780 putative switch regulator; other site 713604022781 non-specific DNA interactions [nucleotide binding]; other site 713604022782 DNA binding site [nucleotide binding] 713604022783 sequence specific DNA binding site [nucleotide binding]; other site 713604022784 putative cAMP binding site [chemical binding]; other site 713604022785 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604022786 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604022787 nucleotide binding site [chemical binding]; other site 713604022788 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 713604022789 active site 713604022790 catalytic residues [active] 713604022791 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604022792 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604022793 putative sugar binding sites [chemical binding]; other site 713604022794 Q-X-W motif; other site 713604022795 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 713604022796 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604022797 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604022798 putative sugar binding sites [chemical binding]; other site 713604022799 Q-X-W motif; other site 713604022800 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 713604022801 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 713604022802 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604022803 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604022804 putative sugar binding sites [chemical binding]; other site 713604022805 Q-X-W motif; other site 713604022806 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604022807 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604022808 putative sugar binding sites [chemical binding]; other site 713604022809 Q-X-W motif; other site 713604022810 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 713604022811 active site 713604022812 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 713604022813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604022814 DNA-binding site [nucleotide binding]; DNA binding site 713604022815 FCD domain; Region: FCD; pfam07729 713604022816 benzoate transport; Region: 2A0115; TIGR00895 713604022817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604022818 putative substrate translocation pore; other site 713604022819 hypothetical protein; Provisional; Region: PRK05463 713604022820 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 713604022821 putative active site [active] 713604022822 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 713604022823 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 713604022824 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 713604022825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604022826 putative DNA binding site [nucleotide binding]; other site 713604022827 dimerization interface [polypeptide binding]; other site 713604022828 putative Zn2+ binding site [ion binding]; other site 713604022829 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 713604022830 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604022831 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 713604022832 putative NAD(P) binding site [chemical binding]; other site 713604022833 catalytic Zn binding site [ion binding]; other site 713604022834 structural Zn binding site [ion binding]; other site 713604022835 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604022836 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604022837 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 713604022838 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 713604022839 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 713604022840 FeoA domain; Region: FeoA; pfam04023 713604022841 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 713604022842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604022843 Coenzyme A binding pocket [chemical binding]; other site 713604022844 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 713604022845 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 713604022846 active site 713604022847 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604022848 substrate binding site [chemical binding]; other site 713604022849 oxyanion hole (OAH) forming residues; other site 713604022850 trimer interface [polypeptide binding]; other site 713604022851 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604022852 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 713604022853 acyl-activating enzyme (AAE) consensus motif; other site 713604022854 putative AMP binding site [chemical binding]; other site 713604022855 putative active site [active] 713604022856 putative CoA binding site [chemical binding]; other site 713604022857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022859 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604022860 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604022861 active site 713604022862 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 713604022863 isochorismate synthase DhbC; Validated; Region: PRK06923 713604022864 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 713604022865 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604022866 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604022867 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 713604022868 dimer interface [polypeptide binding]; other site 713604022869 acyl-activating enzyme (AAE) consensus motif; other site 713604022870 putative active site [active] 713604022871 AMP binding site [chemical binding]; other site 713604022872 putative CoA binding site [chemical binding]; other site 713604022873 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604022874 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604022875 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 713604022876 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604022877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022878 dimer interface [polypeptide binding]; other site 713604022879 conserved gate region; other site 713604022880 putative PBP binding loops; other site 713604022881 ABC-ATPase subunit interface; other site 713604022882 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 713604022883 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604022884 CoenzymeA binding site [chemical binding]; other site 713604022885 subunit interaction site [polypeptide binding]; other site 713604022886 PHB binding site; other site 713604022887 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 713604022888 putative active site [active] 713604022889 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604022890 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604022891 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604022892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604022893 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604022894 DNA binding residues [nucleotide binding] 713604022895 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 713604022896 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 713604022897 NAD binding site [chemical binding]; other site 713604022898 catalytic Zn binding site [ion binding]; other site 713604022899 substrate binding site [chemical binding]; other site 713604022900 structural Zn binding site [ion binding]; other site 713604022901 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 713604022902 putative active site pocket [active] 713604022903 dimerization interface [polypeptide binding]; other site 713604022904 putative catalytic residue [active] 713604022905 FAD binding domain; Region: FAD_binding_4; pfam01565 713604022906 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 713604022907 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022909 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 713604022910 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604022911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604022912 salt bridge; other site 713604022913 non-specific DNA binding site [nucleotide binding]; other site 713604022914 sequence-specific DNA binding site [nucleotide binding]; other site 713604022915 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 713604022916 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 713604022917 Walker A/P-loop; other site 713604022918 ATP binding site [chemical binding]; other site 713604022919 Q-loop/lid; other site 713604022920 ABC transporter signature motif; other site 713604022921 Walker B; other site 713604022922 D-loop; other site 713604022923 H-loop/switch region; other site 713604022924 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 713604022925 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 713604022926 DNA photolyase; Region: DNA_photolyase; pfam00875 713604022927 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 713604022928 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 713604022929 dimer interface [polypeptide binding]; other site 713604022930 active site 713604022931 citrylCoA binding site [chemical binding]; other site 713604022932 NADH binding [chemical binding]; other site 713604022933 cationic pore residues; other site 713604022934 oxalacetate/citrate binding site [chemical binding]; other site 713604022935 coenzyme A binding site [chemical binding]; other site 713604022936 catalytic triad [active] 713604022937 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604022938 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 713604022939 putative substrate binding site [chemical binding]; other site 713604022940 putative ATP binding site [chemical binding]; other site 713604022941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022943 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 713604022944 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604022945 active site 713604022946 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 713604022947 putative active site [active] 713604022948 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 713604022949 putative active site [active] 713604022950 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604022951 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 713604022952 active site 713604022953 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 713604022954 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 713604022955 active site 713604022956 catalytic residues [active] 713604022957 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 713604022958 peptidase domain interface [polypeptide binding]; other site 713604022959 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604022960 active site 713604022961 catalytic triad [active] 713604022962 calcium binding site [ion binding]; other site 713604022963 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022965 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604022966 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 713604022967 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604022968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604022969 putative substrate translocation pore; other site 713604022970 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 713604022971 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604022972 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 713604022973 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604022974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022976 Secretory lipase; Region: LIP; pfam03583 713604022977 UreD urease accessory protein; Region: UreD; cl00530 713604022978 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604022979 AAA domain; Region: AAA_18; pfam13238 713604022980 urease subunit alpha; Reviewed; Region: ureC; PRK13206 713604022981 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 713604022982 subunit interactions [polypeptide binding]; other site 713604022983 active site 713604022984 flap region; other site 713604022985 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 713604022986 gamma-beta subunit interface [polypeptide binding]; other site 713604022987 alpha-beta subunit interface [polypeptide binding]; other site 713604022988 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 713604022989 alpha-gamma subunit interface [polypeptide binding]; other site 713604022990 beta-gamma subunit interface [polypeptide binding]; other site 713604022991 citrate synthase 2; Provisional; Region: PRK12350 713604022992 Citrate synthase; Region: Citrate_synt; pfam00285 713604022993 oxalacetate binding site [chemical binding]; other site 713604022994 citrylCoA binding site [chemical binding]; other site 713604022995 coenzyme A binding site [chemical binding]; other site 713604022996 catalytic triad [active] 713604022997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022999 short chain dehydrogenase; Validated; Region: PRK05855 713604023000 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604023001 classical (c) SDRs; Region: SDR_c; cd05233 713604023002 NAD(P) binding site [chemical binding]; other site 713604023003 active site 713604023004 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604023005 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604023006 Walker A/P-loop; other site 713604023007 ATP binding site [chemical binding]; other site 713604023008 Q-loop/lid; other site 713604023009 ABC transporter signature motif; other site 713604023010 Walker B; other site 713604023011 D-loop; other site 713604023012 H-loop/switch region; other site 713604023013 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604023014 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604023015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604023016 Histidine kinase; Region: HisKA_3; pfam07730 713604023017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604023018 ATP binding site [chemical binding]; other site 713604023019 G-X-G motif; other site 713604023020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604023021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604023022 active site 713604023023 phosphorylation site [posttranslational modification] 713604023024 intermolecular recognition site; other site 713604023025 dimerization interface [polypeptide binding]; other site 713604023026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604023027 DNA binding residues [nucleotide binding] 713604023028 dimerization interface [polypeptide binding]; other site 713604023029 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604023030 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604023031 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604023032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604023033 catalytic residue [active] 713604023034 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 713604023035 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604023036 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604023037 active site 713604023038 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604023039 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 713604023040 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 713604023041 FtsX-like permease family; Region: FtsX; pfam02687 713604023042 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604023043 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604023044 Walker A/P-loop; other site 713604023045 ATP binding site [chemical binding]; other site 713604023046 Q-loop/lid; other site 713604023047 ABC transporter signature motif; other site 713604023048 Walker B; other site 713604023049 D-loop; other site 713604023050 H-loop/switch region; other site 713604023051 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604023052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604023053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604023054 active site 713604023055 phosphorylation site [posttranslational modification] 713604023056 intermolecular recognition site; other site 713604023057 dimerization interface [polypeptide binding]; other site 713604023058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604023059 DNA binding site [nucleotide binding] 713604023060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604023061 dimerization interface [polypeptide binding]; other site 713604023062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604023063 dimer interface [polypeptide binding]; other site 713604023064 phosphorylation site [posttranslational modification] 713604023065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604023066 ATP binding site [chemical binding]; other site 713604023067 Mg2+ binding site [ion binding]; other site 713604023068 G-X-G motif; other site 713604023069 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 713604023070 Protein of unknown function (DUF419); Region: DUF419; pfam04237 713604023071 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 713604023072 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 713604023073 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604023074 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604023075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023076 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 713604023077 heme binding pocket [chemical binding]; other site 713604023078 heme ligand [chemical binding]; other site 713604023079 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 713604023080 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 713604023081 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 713604023082 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 713604023083 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604023084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604023085 putative substrate translocation pore; other site 713604023086 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604023087 MarR family; Region: MarR; pfam01047 713604023088 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 713604023089 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 713604023090 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 713604023091 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 713604023092 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604023093 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 713604023094 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604023095 DNA-binding site [nucleotide binding]; DNA binding site 713604023096 RNA-binding motif; other site 713604023097 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 713604023098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 713604023099 motif II; other site 713604023100 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 713604023101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604023102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023103 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 713604023104 active site 713604023105 diiron metal binding site [ion binding]; other site 713604023106 AMP-binding domain protein; Validated; Region: PRK08315 713604023107 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604023108 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 713604023109 acyl-activating enzyme (AAE) consensus motif; other site 713604023110 putative AMP binding site [chemical binding]; other site 713604023111 putative active site [active] 713604023112 putative CoA binding site [chemical binding]; other site 713604023113 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604023114 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604023115 DNA binding residues [nucleotide binding] 713604023116 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604023117 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604023118 putative sugar binding sites [chemical binding]; other site 713604023119 Q-X-W motif; other site 713604023120 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 713604023121 Asp-box motif; other site 713604023122 Ycf46; Provisional; Region: ycf46; CHL00195 713604023123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023124 Walker A motif; other site 713604023125 ATP binding site [chemical binding]; other site 713604023126 Walker B motif; other site 713604023127 arginine finger; other site 713604023128 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 713604023129 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 713604023130 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604023131 FeS/SAM binding site; other site 713604023132 EspG family; Region: ESX-1_EspG; pfam14011 713604023133 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 713604023134 hypothetical protein; Provisional; Region: PRK11770 713604023135 Domain of unknown function (DUF307); Region: DUF307; pfam03733 713604023136 Domain of unknown function (DUF307); Region: DUF307; pfam03733 713604023137 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604023138 active site 713604023139 metal binding site [ion binding]; metal-binding site 713604023140 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 713604023141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604023142 active site 713604023143 motif I; other site 713604023144 motif II; other site 713604023145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604023146 FtsI repressor; Provisional; Region: PRK10883 713604023147 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 713604023148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604023149 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 713604023150 Walker A/P-loop; other site 713604023151 ATP binding site [chemical binding]; other site 713604023152 Q-loop/lid; other site 713604023153 ABC transporter signature motif; other site 713604023154 Walker B; other site 713604023155 D-loop; other site 713604023156 H-loop/switch region; other site 713604023157 TOBE domain; Region: TOBE; pfam03459 713604023158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604023159 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 713604023160 putative PBP binding loops; other site 713604023161 ABC-ATPase subunit interface; other site 713604023162 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 713604023163 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604023164 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 713604023165 DNA binding residues [nucleotide binding] 713604023166 TOBE domain; Region: TOBE; cl01440 713604023167 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604023168 MarR family; Region: MarR; pfam01047 713604023169 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 713604023170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604023171 FeS/SAM binding site; other site 713604023172 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 713604023173 Ubiquitin-like proteins; Region: UBQ; cl00155 713604023174 charged pocket; other site 713604023175 hydrophobic patch; other site 713604023176 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 713604023177 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 713604023178 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 713604023179 MPT binding site; other site 713604023180 trimer interface [polypeptide binding]; other site 713604023181 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 713604023182 MoaE homodimer interface [polypeptide binding]; other site 713604023183 MoaD interaction [polypeptide binding]; other site 713604023184 active site residues [active] 713604023185 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 713604023186 trimer interface [polypeptide binding]; other site 713604023187 dimer interface [polypeptide binding]; other site 713604023188 putative active site [active] 713604023189 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 713604023190 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 713604023191 Malic enzyme, N-terminal domain; Region: malic; pfam00390 713604023192 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 713604023193 NAD(P) binding pocket [chemical binding]; other site 713604023194 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 713604023195 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604023196 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604023197 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604023198 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604023199 G1 box; other site 713604023200 GTP/Mg2+ binding site [chemical binding]; other site 713604023201 G2 box; other site 713604023202 Switch I region; other site 713604023203 G3 box; other site 713604023204 Switch II region; other site 713604023205 G4 box; other site 713604023206 G5 box; other site 713604023207 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604023208 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604023209 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604023210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604023211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604023212 ATP binding site [chemical binding]; other site 713604023213 Mg2+ binding site [ion binding]; other site 713604023214 G-X-G motif; other site 713604023215 NMT1/THI5 like; Region: NMT1; pfam09084 713604023216 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604023217 substrate binding pocket [chemical binding]; other site 713604023218 membrane-bound complex binding site; other site 713604023219 hinge residues; other site 713604023220 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604023221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604023222 dimer interface [polypeptide binding]; other site 713604023223 conserved gate region; other site 713604023224 putative PBP binding loops; other site 713604023225 ABC-ATPase subunit interface; other site 713604023226 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604023227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604023228 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604023229 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604023230 Walker A/P-loop; other site 713604023231 ATP binding site [chemical binding]; other site 713604023232 Q-loop/lid; other site 713604023233 ABC transporter signature motif; other site 713604023234 Walker B; other site 713604023235 D-loop; other site 713604023236 H-loop/switch region; other site 713604023237 benzoylformate decarboxylase; Reviewed; Region: PRK07092 713604023238 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604023239 dimer interface [polypeptide binding]; other site 713604023240 PYR/PP interface [polypeptide binding]; other site 713604023241 TPP binding site [chemical binding]; other site 713604023242 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604023243 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 713604023244 TPP-binding site [chemical binding]; other site 713604023245 dimer interface [polypeptide binding]; other site 713604023246 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604023247 Helix-turn-helix; Region: HTH_3; pfam01381 713604023248 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 713604023249 peptidase domain interface [polypeptide binding]; other site 713604023250 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604023251 active site 713604023252 catalytic triad [active] 713604023253 calcium binding site [ion binding]; other site 713604023254 potential frameshift: common BLAST hit: gi|256374197|ref|YP_003097857.1| XRE family transcriptional regulator 713604023255 CutC family; Region: CutC; cl01218 713604023256 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604023257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604023258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604023259 ATP binding site [chemical binding]; other site 713604023260 Mg2+ binding site [ion binding]; other site 713604023261 G-X-G motif; other site 713604023262 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 713604023263 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 713604023264 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 713604023265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604023266 ATP binding site [chemical binding]; other site 713604023267 putative Mg++ binding site [ion binding]; other site 713604023268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604023269 nucleotide binding region [chemical binding]; other site 713604023270 ATP-binding site [chemical binding]; other site 713604023271 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 713604023272 Protein of unknown function DUF72; Region: DUF72; pfam01904 713604023273 O-succinylbenzoate synthase; Provisional; Region: PRK02901 713604023274 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 713604023275 active site 713604023276 PspC domain; Region: PspC; pfam04024 713604023277 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 713604023278 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 713604023279 ring oligomerisation interface [polypeptide binding]; other site 713604023280 ATP/Mg binding site [chemical binding]; other site 713604023281 stacking interactions; other site 713604023282 hinge regions; other site 713604023283 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 713604023284 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604023285 active site 713604023286 ATP binding site [chemical binding]; other site 713604023287 substrate binding site [chemical binding]; other site 713604023288 activation loop (A-loop); other site 713604023289 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604023290 DNA-binding site [nucleotide binding]; DNA binding site 713604023291 RNA-binding motif; other site 713604023292 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 713604023293 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 713604023294 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 713604023295 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 713604023296 dimer interface [polypeptide binding]; other site 713604023297 putative functional site; other site 713604023298 putative MPT binding site; other site 713604023299 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604023300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604023301 putative DNA binding site [nucleotide binding]; other site 713604023302 putative Zn2+ binding site [ion binding]; other site 713604023303 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 713604023304 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 713604023305 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 713604023306 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 713604023307 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 713604023308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023309 Walker A motif; other site 713604023310 ATP binding site [chemical binding]; other site 713604023311 Walker B motif; other site 713604023312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023313 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604023314 Walker A motif; other site 713604023315 ATP binding site [chemical binding]; other site 713604023316 Walker B motif; other site 713604023317 arginine finger; other site 713604023318 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 713604023319 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 713604023320 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 713604023321 active site 713604023322 catalytic residues [active] 713604023323 metal binding site [ion binding]; metal-binding site 713604023324 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 713604023325 Domain interface; other site 713604023326 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 713604023327 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604023328 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604023329 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604023330 protein binding site [polypeptide binding]; other site 713604023331 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 713604023332 ThiC-associated domain; Region: ThiC-associated; pfam13667 713604023333 ThiC family; Region: ThiC; pfam01964 713604023334 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 713604023335 dimer interface [polypeptide binding]; other site 713604023336 substrate binding site [chemical binding]; other site 713604023337 ATP binding site [chemical binding]; other site 713604023338 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 713604023339 putative active site [active] 713604023340 catalytic site [active] 713604023341 putative metal binding site [ion binding]; other site 713604023342 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 713604023343 substrate binding site [chemical binding]; other site 713604023344 dimer interface [polypeptide binding]; other site 713604023345 ATP binding site [chemical binding]; other site 713604023346 MarR family; Region: MarR; pfam01047 713604023347 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604023348 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 713604023349 ThiS interaction site; other site 713604023350 putative active site [active] 713604023351 tetramer interface [polypeptide binding]; other site 713604023352 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 713604023353 thiS-thiF/thiG interaction site; other site 713604023354 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 713604023355 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 713604023356 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 713604023357 thiamine phosphate binding site [chemical binding]; other site 713604023358 active site 713604023359 pyrophosphate binding site [ion binding]; other site 713604023360 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 713604023361 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 713604023362 tetramer interface [polypeptide binding]; other site 713604023363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604023364 catalytic residue [active] 713604023365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604023366 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604023367 putative substrate translocation pore; other site 713604023368 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 713604023369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604023370 DNA-binding site [nucleotide binding]; DNA binding site 713604023371 UTRA domain; Region: UTRA; pfam07702 713604023372 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 713604023373 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 713604023374 dimer interface [polypeptide binding]; other site 713604023375 active site 713604023376 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 713604023377 dimer interface [polypeptide binding]; other site 713604023378 active site 713604023379 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 713604023380 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 713604023381 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 713604023382 active site 713604023383 catalytic triad [active] 713604023384 oxyanion hole [active] 713604023385 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 713604023386 ligand binding site [chemical binding]; other site 713604023387 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 713604023388 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604023389 DNA binding site [nucleotide binding] 713604023390 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604023391 NB-ARC domain; Region: NB-ARC; pfam00931 713604023392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604023393 binding surface 713604023394 TPR motif; other site 713604023395 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604023396 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 713604023397 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 713604023398 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 713604023399 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604023400 inhibitor-cofactor binding pocket; inhibition site 713604023401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604023402 catalytic residue [active] 713604023403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604023404 Coenzyme A binding pocket [chemical binding]; other site 713604023405 Patatin-like phospholipase; Region: Patatin; pfam01734 713604023406 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 713604023407 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 713604023408 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604023409 putative NAD(P) binding site [chemical binding]; other site 713604023410 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604023411 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604023412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 713604023413 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 713604023414 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604023415 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604023416 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 713604023417 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 713604023418 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 713604023419 active site 713604023420 dimer interface [polypeptide binding]; other site 713604023421 MarR family; Region: MarR_2; pfam12802 713604023422 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604023423 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604023424 active site 713604023425 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 713604023426 active site 713604023427 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 713604023428 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604023429 acyl-activating enzyme (AAE) consensus motif; other site 713604023430 AMP binding site [chemical binding]; other site 713604023431 active site 713604023432 CoA binding site [chemical binding]; other site 713604023433 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 713604023434 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 713604023435 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604023436 substrate binding site [chemical binding]; other site 713604023437 oxyanion hole (OAH) forming residues; other site 713604023438 trimer interface [polypeptide binding]; other site 713604023439 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604023440 substrate binding site [chemical binding]; other site 713604023441 trimer interface [polypeptide binding]; other site 713604023442 oxyanion hole (OAH) forming residues; other site 713604023443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604023444 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604023445 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604023446 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604023447 PA14 domain; Region: PA14; cl08459 713604023448 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604023449 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604023450 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604023451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023452 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604023453 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604023454 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604023455 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604023456 RibD C-terminal domain; Region: RibD_C; cl17279 713604023457 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604023458 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604023459 MarR family; Region: MarR_2; pfam12802 713604023460 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 713604023461 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 713604023462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604023463 Walker A/P-loop; other site 713604023464 ATP binding site [chemical binding]; other site 713604023465 Q-loop/lid; other site 713604023466 ABC transporter signature motif; other site 713604023467 Walker B; other site 713604023468 D-loop; other site 713604023469 H-loop/switch region; other site 713604023470 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 713604023471 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 713604023472 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 713604023473 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604023474 Zn binding site [ion binding]; other site 713604023475 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 713604023476 NHL repeat; Region: NHL; pfam01436 713604023477 NHL repeat; Region: NHL; pfam01436 713604023478 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 713604023479 Gas vesicle protein; Region: Gas_vesicle; cl02954 713604023480 Gas vesicle protein K; Region: GvpK; pfam05121 713604023481 Gas vesicle protein; Region: Gas_vesicle; cl02954 713604023482 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 713604023483 Gas vesicle protein; Region: Gas_vesicle; pfam00741 713604023484 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 713604023485 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604023486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604023487 active site 713604023488 phosphorylation site [posttranslational modification] 713604023489 intermolecular recognition site; other site 713604023490 dimerization interface [polypeptide binding]; other site 713604023491 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604023492 DNA binding site [nucleotide binding] 713604023493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604023494 dimerization interface [polypeptide binding]; other site 713604023495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604023496 dimer interface [polypeptide binding]; other site 713604023497 phosphorylation site [posttranslational modification] 713604023498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604023499 ATP binding site [chemical binding]; other site 713604023500 Mg2+ binding site [ion binding]; other site 713604023501 G-X-G motif; other site 713604023502 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 713604023503 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713604023504 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 713604023505 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604023506 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604023507 putative NAD(P) binding site [chemical binding]; other site 713604023508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023509 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604023510 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 713604023511 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604023512 L-lactate permease; Region: Lactate_perm; cl00701 713604023513 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 713604023514 HD domain; Region: HD_3; pfam13023 713604023515 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604023516 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604023517 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604023518 YCII-related domain; Region: YCII; cl00999 713604023519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 713604023520 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 713604023521 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604023522 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604023523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604023524 HAMP domain; Region: HAMP; pfam00672 713604023525 dimerization interface [polypeptide binding]; other site 713604023526 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604023527 dimer interface [polypeptide binding]; other site 713604023528 phosphorylation site [posttranslational modification] 713604023529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604023530 ATP binding site [chemical binding]; other site 713604023531 Mg2+ binding site [ion binding]; other site 713604023532 G-X-G motif; other site 713604023533 Predicted membrane protein [Function unknown]; Region: COG3463 713604023534 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 713604023535 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 713604023536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604023537 binding surface 713604023538 TPR motif; other site 713604023539 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604023540 CHAT domain; Region: CHAT; pfam12770 713604023541 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604023542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604023543 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604023544 active site 713604023545 catalytic residues [active] 713604023546 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 713604023547 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604023548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604023549 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604023550 DNA binding residues [nucleotide binding] 713604023551 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604023552 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 713604023553 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604023554 sugar binding site [chemical binding]; other site 713604023555 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 713604023556 Ca binding site [ion binding]; other site 713604023557 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 713604023558 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 713604023559 Ca binding site [ion binding]; other site 713604023560 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 713604023561 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604023562 active site 713604023563 catalytic triad [active] 713604023564 calcium binding site [ion binding]; other site 713604023565 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 713604023566 Erythromycin esterase; Region: Erythro_esteras; pfam05139 713604023567 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 713604023568 DNA binding residues [nucleotide binding] 713604023569 mercuric resistence transcriptional repressor protein MerD; Region: MerD; TIGR02054 713604023570 putative dimer interface [polypeptide binding]; other site 713604023571 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 713604023572 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604023573 DNA binding residues [nucleotide binding] 713604023574 putative dimer interface [polypeptide binding]; other site 713604023575 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604023576 Uncharacterized conserved protein [Function unknown]; Region: COG2966 713604023577 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 713604023578 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 713604023579 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 713604023580 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 713604023581 active site 713604023582 homotetramer interface [polypeptide binding]; other site 713604023583 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 713604023584 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 713604023585 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 713604023586 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604023587 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604023588 dimerization interface [polypeptide binding]; other site 713604023589 putative DNA binding site [nucleotide binding]; other site 713604023590 putative Zn2+ binding site [ion binding]; other site 713604023591 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604023592 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604023593 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604023594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604023595 DNA repair protein RadA; Provisional; Region: PRK11823 713604023596 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604023597 Walker A motif; other site 713604023598 ATP binding site [chemical binding]; other site 713604023599 Walker B motif; other site 713604023600 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 713604023601 Protein of unknown function (DUF461); Region: DUF461; cl01071 713604023602 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 713604023603 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604023604 active site 713604023605 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 713604023606 homotrimer interaction site [polypeptide binding]; other site 713604023607 zinc binding site [ion binding]; other site 713604023608 CDP-binding sites; other site 713604023609 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604023610 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604023611 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 713604023612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604023613 motif II; other site 713604023614 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 713604023615 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604023616 active site 713604023617 HIGH motif; other site 713604023618 nucleotide binding site [chemical binding]; other site 713604023619 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 713604023620 KMSKS motif; other site 713604023621 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 713604023622 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 713604023623 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 713604023624 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 713604023625 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 713604023626 phosphoglycerate mutase; Provisional; Region: PTZ00122 713604023627 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604023628 catalytic core [active] 713604023629 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 713604023630 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 713604023631 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 713604023632 intersubunit interface [polypeptide binding]; other site 713604023633 active site 713604023634 Zn2+ binding site [ion binding]; other site 713604023635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 713604023636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 713604023637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 713604023638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 713604023639 dimer interface [polypeptide binding]; other site 713604023640 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 713604023641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 713604023642 putative PBP binding regions; other site 713604023643 ABC-ATPase subunit interface; other site 713604023644 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 713604023645 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604023646 Walker A/P-loop; other site 713604023647 ATP binding site [chemical binding]; other site 713604023648 Q-loop/lid; other site 713604023649 ABC transporter signature motif; other site 713604023650 Walker B; other site 713604023651 D-loop; other site 713604023652 H-loop/switch region; other site 713604023653 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 713604023654 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 713604023655 intersubunit interface [polypeptide binding]; other site 713604023656 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604023657 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604023658 DNA binding site [nucleotide binding] 713604023659 domain linker motif; other site 713604023660 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 713604023661 putative dimerization interface [polypeptide binding]; other site 713604023662 putative ligand binding site [chemical binding]; other site 713604023663 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 713604023664 active site clefts [active] 713604023665 zinc binding site [ion binding]; other site 713604023666 dimer interface [polypeptide binding]; other site 713604023667 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604023668 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604023669 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 713604023670 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 713604023671 minor groove reading motif; other site 713604023672 helix-hairpin-helix signature motif; other site 713604023673 active site 713604023674 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 713604023675 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 713604023676 amidase catalytic site [active] 713604023677 Zn binding residues [ion binding]; other site 713604023678 substrate binding site [chemical binding]; other site 713604023679 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604023680 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604023681 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604023682 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 713604023683 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 713604023684 Peptidase family M1; Region: Peptidase_M1; pfam01433 713604023685 Zn binding site [ion binding]; other site 713604023686 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604023687 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023688 Walker A motif; other site 713604023689 ATP binding site [chemical binding]; other site 713604023690 Walker B motif; other site 713604023691 arginine finger; other site 713604023692 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 713604023693 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 713604023694 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 713604023695 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604023696 Walker A motif; other site 713604023697 ATP binding site [chemical binding]; other site 713604023698 Walker B motif; other site 713604023699 hypothetical protein; Validated; Region: PRK09169 713604023700 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 713604023701 putative catalytic site [active] 713604023702 putative metal binding site [ion binding]; other site 713604023703 putative phosphate binding site [ion binding]; other site 713604023704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604023705 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604023706 Walker A/P-loop; other site 713604023707 ATP binding site [chemical binding]; other site 713604023708 Q-loop/lid; other site 713604023709 ABC transporter signature motif; other site 713604023710 Walker B; other site 713604023711 D-loop; other site 713604023712 H-loop/switch region; other site 713604023713 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 713604023714 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604023715 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604023716 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604023717 Predicted ATPase [General function prediction only]; Region: COG3903 713604023718 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 713604023719 Zn binding site [ion binding]; other site 713604023720 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 713604023721 putative substrate binding pocket [chemical binding]; other site 713604023722 AC domain interface; other site 713604023723 catalytic triad [active] 713604023724 AB domain interface; other site 713604023725 interchain disulfide; other site 713604023726 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 713604023727 nucleotide binding site [chemical binding]; other site 713604023728 putative NEF/HSP70 interaction site [polypeptide binding]; other site 713604023729 SBD interface [polypeptide binding]; other site 713604023730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604023731 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604023732 non-specific DNA binding site [nucleotide binding]; other site 713604023733 salt bridge; other site 713604023734 sequence-specific DNA binding site [nucleotide binding]; other site 713604023735 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 713604023736 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 713604023737 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 713604023738 Clp amino terminal domain; Region: Clp_N; pfam02861 713604023739 Clp amino terminal domain; Region: Clp_N; pfam02861 713604023740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023741 Walker A motif; other site 713604023742 ATP binding site [chemical binding]; other site 713604023743 Walker B motif; other site 713604023744 arginine finger; other site 713604023745 UvrB/uvrC motif; Region: UVR; pfam02151 713604023746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023747 Walker A motif; other site 713604023748 ATP binding site [chemical binding]; other site 713604023749 Walker B motif; other site 713604023750 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 713604023751 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 713604023752 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604023753 TIGR03086 family protein; Region: TIGR03086 713604023754 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604023755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604023756 Lsr2; Region: Lsr2; pfam11774 713604023757 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 713604023758 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 713604023759 dimer interface [polypeptide binding]; other site 713604023760 putative anticodon binding site; other site 713604023761 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604023762 motif 1; other site 713604023763 dimer interface [polypeptide binding]; other site 713604023764 active site 713604023765 motif 2; other site 713604023766 motif 3; other site 713604023767 Methyltransferase domain; Region: Methyltransf_11; pfam08241 713604023768 pantothenate kinase; Reviewed; Region: PRK13318 713604023769 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 713604023770 tetramerization interface [polypeptide binding]; other site 713604023771 active site 713604023772 Pantoate-beta-alanine ligase; Region: PanC; cd00560 713604023773 pantoate--beta-alanine ligase; Region: panC; TIGR00018 713604023774 active site 713604023775 ATP-binding site [chemical binding]; other site 713604023776 pantoate-binding site; other site 713604023777 HXXH motif; other site 713604023778 Rossmann-like domain; Region: Rossmann-like; pfam10727 713604023779 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 713604023780 Protease prsW family; Region: PrsW-protease; pfam13367 713604023781 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 713604023782 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604023783 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604023784 DNA binding residues [nucleotide binding] 713604023785 dimer interface [polypeptide binding]; other site 713604023786 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 713604023787 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 713604023788 catalytic center binding site [active] 713604023789 ATP binding site [chemical binding]; other site 713604023790 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 713604023791 homooctamer interface [polypeptide binding]; other site 713604023792 active site 713604023793 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 713604023794 dihydropteroate synthase; Region: DHPS; TIGR01496 713604023795 substrate binding pocket [chemical binding]; other site 713604023796 dimer interface [polypeptide binding]; other site 713604023797 inhibitor binding site; inhibition site 713604023798 GTP cyclohydrolase I; Provisional; Region: PLN03044 713604023799 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 713604023800 homodecamer interface [polypeptide binding]; other site 713604023801 active site 713604023802 putative catalytic site residues [active] 713604023803 zinc binding site [ion binding]; other site 713604023804 GTP-CH-I/GFRP interaction surface; other site 713604023805 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 713604023806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023807 Walker A motif; other site 713604023808 ATP binding site [chemical binding]; other site 713604023809 Walker B motif; other site 713604023810 arginine finger; other site 713604023811 Peptidase family M41; Region: Peptidase_M41; pfam01434 713604023812 EspG family; Region: ESX-1_EspG; pfam14011 713604023813 EspG family; Region: ESX-1_EspG; pfam14011 713604023814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604023815 active site 713604023816 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 713604023817 Ligand Binding Site [chemical binding]; other site 713604023818 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 713604023819 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 713604023820 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 713604023821 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 713604023822 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 713604023823 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 713604023824 dimer interface [polypeptide binding]; other site 713604023825 substrate binding site [chemical binding]; other site 713604023826 metal binding sites [ion binding]; metal-binding site 713604023827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604023828 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604023829 putative substrate translocation pore; other site 713604023830 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 713604023831 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 713604023832 dimer interface [polypeptide binding]; other site 713604023833 active site 713604023834 glycine-pyridoxal phosphate binding site [chemical binding]; other site 713604023835 folate binding site [chemical binding]; other site 713604023836 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 713604023837 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 713604023838 23S rRNA interface [nucleotide binding]; other site 713604023839 L7/L12 interface [polypeptide binding]; other site 713604023840 putative thiostrepton binding site; other site 713604023841 L25 interface [polypeptide binding]; other site 713604023842 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 713604023843 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 713604023844 trimer interface [polypeptide binding]; other site 713604023845 putative metal binding site [ion binding]; other site 713604023846 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 713604023847 putative active site [active] 713604023848 Zn binding site [ion binding]; other site 713604023849 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 713604023850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023851 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 713604023852 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 713604023853 EthD domain; Region: EthD; cl17553 713604023854 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604023855 active site 713604023856 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604023857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604023858 non-specific DNA binding site [nucleotide binding]; other site 713604023859 salt bridge; other site 713604023860 sequence-specific DNA binding site [nucleotide binding]; other site 713604023861 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604023862 nudix motif; other site 713604023863 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604023864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604023865 non-specific DNA binding site [nucleotide binding]; other site 713604023866 salt bridge; other site 713604023867 sequence-specific DNA binding site [nucleotide binding]; other site 713604023868 Phosphotransferase enzyme family; Region: APH; pfam01636 713604023869 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 713604023870 substrate binding site [chemical binding]; other site 713604023871 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604023872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604023873 DNA-binding site [nucleotide binding]; DNA binding site 713604023874 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604023875 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 713604023876 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604023877 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 713604023878 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604023879 active site 713604023880 DNA binding site [nucleotide binding] 713604023881 Int/Topo IB signature motif; other site 713604023882 DNA polymerase III subunit delta'; Validated; Region: PRK07940 713604023883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023884 Walker A motif; other site 713604023885 ATP binding site [chemical binding]; other site 713604023886 Walker B motif; other site 713604023887 arginine finger; other site 713604023888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604023889 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604023890 putative substrate translocation pore; other site 713604023891 thymidylate kinase; Validated; Region: tmk; PRK00698 713604023892 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 713604023893 TMP-binding site; other site 713604023894 ATP-binding site [chemical binding]; other site 713604023895 EspG family; Region: ESX-1_EspG; pfam14011 713604023896 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 713604023897 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 713604023898 active site 713604023899 interdomain interaction site; other site 713604023900 putative metal-binding site [ion binding]; other site 713604023901 nucleotide binding site [chemical binding]; other site 713604023902 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 713604023903 domain I; other site 713604023904 phosphate binding site [ion binding]; other site 713604023905 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 713604023906 domain II; other site 713604023907 domain III; other site 713604023908 nucleotide binding site [chemical binding]; other site 713604023909 DNA binding groove [nucleotide binding] 713604023910 catalytic site [active] 713604023911 domain IV; other site 713604023912 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 713604023913 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 713604023914 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 713604023915 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604023916 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 713604023917 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 713604023918 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 713604023919 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604023920 ATP binding site [chemical binding]; other site 713604023921 putative Mg++ binding site [ion binding]; other site 713604023922 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604023923 nucleotide binding region [chemical binding]; other site 713604023924 ATP-binding site [chemical binding]; other site 713604023925 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 713604023926 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 713604023927 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 713604023928 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 713604023929 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604023930 Type II/IV secretion system protein; Region: T2SE; pfam00437 713604023931 Walker A motif; other site 713604023932 ATP binding site [chemical binding]; other site 713604023933 Walker B motif; other site 713604023934 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 713604023935 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 713604023936 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 713604023937 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604023938 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604023939 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604023940 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 713604023941 Beta-lactamase; Region: Beta-lactamase; cl17358 713604023942 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604023943 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 713604023944 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 713604023945 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 713604023946 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 713604023947 putative active site [active] 713604023948 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 713604023949 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 713604023950 putative active site [active] 713604023951 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 713604023952 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 713604023953 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604023954 active site 713604023955 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604023956 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604023957 acetyl-CoA synthetase; Provisional; Region: PRK00174 713604023958 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 713604023959 active site 713604023960 CoA binding site [chemical binding]; other site 713604023961 acyl-activating enzyme (AAE) consensus motif; other site 713604023962 AMP binding site [chemical binding]; other site 713604023963 acetate binding site [chemical binding]; other site 713604023964 Cupin domain; Region: Cupin_2; pfam07883 713604023965 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 713604023966 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 713604023967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604023968 putative substrate translocation pore; other site 713604023969 POT family; Region: PTR2; cl17359 713604023970 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 713604023971 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 713604023972 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604023973 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604023974 hypothetical protein; Validated; Region: PRK05868 713604023975 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604023976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604023977 DNA-binding site [nucleotide binding]; DNA binding site 713604023978 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604023979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023980 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604023981 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 713604023982 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604023983 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 713604023984 putative active site [active] 713604023985 putative CoA binding site [chemical binding]; other site 713604023986 nudix motif; other site 713604023987 metal binding site [ion binding]; metal-binding site 713604023988 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 713604023989 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 713604023990 catalytic residues [active] 713604023991 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 713604023992 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 713604023993 minor groove reading motif; other site 713604023994 helix-hairpin-helix signature motif; other site 713604023995 substrate binding pocket [chemical binding]; other site 713604023996 active site 713604023997 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 713604023998 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604023999 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604024000 ligand binding site [chemical binding]; other site 713604024001 flexible hinge region; other site 713604024002 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 713604024003 putative switch regulator; other site 713604024004 non-specific DNA interactions [nucleotide binding]; other site 713604024005 DNA binding site [nucleotide binding] 713604024006 sequence specific DNA binding site [nucleotide binding]; other site 713604024007 putative cAMP binding site [chemical binding]; other site 713604024008 potential frameshift: common BLAST hit: gi|300790637|ref|YP_003770928.1| transposase IS4 family protein 713604024009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 713604024010 putative DNA binding surface [nucleotide binding]; other site 713604024011 dimer interface [polypeptide binding]; other site 713604024012 beta-clamp/clamp loader binding surface; other site 713604024013 beta-clamp/translesion DNA polymerase binding surface; other site 713604024014 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604024015 AsnC family; Region: AsnC_trans_reg; pfam01037 713604024016 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604024017 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604024018 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 713604024019 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 713604024020 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604024021 substrate binding pocket [chemical binding]; other site 713604024022 catalytic triad [active] 713604024023 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 713604024024 catalytic residues [active] 713604024025 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 713604024026 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 713604024027 nudix motif; other site 713604024028 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 713604024029 homotrimer interaction site [polypeptide binding]; other site 713604024030 putative active site [active] 713604024031 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 713604024032 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 713604024033 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 713604024034 DTAP/Switch II; other site 713604024035 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 713604024036 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 713604024037 P loop; other site 713604024038 Nucleotide binding site [chemical binding]; other site 713604024039 DTAP/Switch II; other site 713604024040 Switch I; other site 713604024041 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 713604024042 Transcription factor WhiB; Region: Whib; pfam02467 713604024043 Transglycosylase; Region: Transgly; pfam00912 713604024044 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 713604024045 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604024046 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604024047 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604024048 active site 713604024049 ATP binding site [chemical binding]; other site 713604024050 substrate binding site [chemical binding]; other site 713604024051 activation loop (A-loop); other site 713604024052 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 713604024053 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604024054 putative active site [active] 713604024055 putative metal binding site [ion binding]; other site 713604024056 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604024057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604024058 S-adenosylmethionine binding site [chemical binding]; other site 713604024059 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604024060 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604024061 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 713604024062 active site 1 [active] 713604024063 dimer interface [polypeptide binding]; other site 713604024064 hexamer interface [polypeptide binding]; other site 713604024065 active site 2 [active] 713604024066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604024067 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 713604024068 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 713604024069 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 713604024070 TIGR03085 family protein; Region: TIGR03085 713604024071 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 713604024072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604024073 catalytic residue [active] 713604024074 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 713604024075 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 713604024076 dimerization interface [polypeptide binding]; other site 713604024077 DPS ferroxidase diiron center [ion binding]; other site 713604024078 ion pore; other site 713604024079 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 713604024080 Predicted flavoprotein [General function prediction only]; Region: COG0431 713604024081 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604024082 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604024083 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604024084 substrate binding pocket [chemical binding]; other site 713604024085 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604024086 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604024087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604024090 putative substrate translocation pore; other site 713604024091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024093 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604024094 putative substrate translocation pore; other site 713604024095 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 713604024096 hypothetical protein; Reviewed; Region: PRK09588 713604024097 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 713604024098 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 713604024099 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 713604024100 aspartate kinase; Reviewed; Region: PRK06635 713604024101 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 713604024102 putative nucleotide binding site [chemical binding]; other site 713604024103 putative catalytic residues [active] 713604024104 putative Mg ion binding site [ion binding]; other site 713604024105 putative aspartate binding site [chemical binding]; other site 713604024106 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 713604024107 putative allosteric regulatory site; other site 713604024108 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 713604024109 putative allosteric regulatory residue; other site 713604024110 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 713604024111 putative FMN binding site [chemical binding]; other site 713604024112 2-isopropylmalate synthase; Validated; Region: PRK03739 713604024113 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 713604024114 active site 713604024115 catalytic residues [active] 713604024116 metal binding site [ion binding]; metal-binding site 713604024117 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 713604024118 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604024119 HTH domain; Region: HTH_11; pfam08279 713604024120 WYL domain; Region: WYL; pfam13280 713604024121 short chain dehydrogenase; Provisional; Region: PRK08303 713604024122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604024123 NAD(P) binding site [chemical binding]; other site 713604024124 active site 713604024125 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604024126 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 713604024127 putative catalytic residues [active] 713604024128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604024129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024130 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604024131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604024132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604024133 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604024134 putative dimerization interface [polypeptide binding]; other site 713604024135 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 713604024136 EamA-like transporter family; Region: EamA; pfam00892 713604024137 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604024138 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 713604024139 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 713604024140 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604024141 YCII-related domain; Region: YCII; cl00999 713604024142 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604024143 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604024144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604024145 DNA binding residues [nucleotide binding] 713604024146 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 713604024147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604024148 Walker A/P-loop; other site 713604024149 ATP binding site [chemical binding]; other site 713604024150 Q-loop/lid; other site 713604024151 ABC transporter signature motif; other site 713604024152 Walker B; other site 713604024153 D-loop; other site 713604024154 H-loop/switch region; other site 713604024155 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 713604024156 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604024157 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604024158 Walker A/P-loop; other site 713604024159 ATP binding site [chemical binding]; other site 713604024160 Q-loop/lid; other site 713604024161 ABC transporter signature motif; other site 713604024162 Walker B; other site 713604024163 D-loop; other site 713604024164 H-loop/switch region; other site 713604024165 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604024166 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 713604024167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024168 dimer interface [polypeptide binding]; other site 713604024169 conserved gate region; other site 713604024170 putative PBP binding loops; other site 713604024171 ABC-ATPase subunit interface; other site 713604024172 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604024173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024174 dimer interface [polypeptide binding]; other site 713604024175 conserved gate region; other site 713604024176 putative PBP binding loops; other site 713604024177 ABC-ATPase subunit interface; other site 713604024178 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 713604024179 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 713604024180 peptide binding site [polypeptide binding]; other site 713604024181 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 713604024182 Ligand binding site; other site 713604024183 Putative Catalytic site; other site 713604024184 DXD motif; other site 713604024185 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604024186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 713604024187 active site 713604024188 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604024189 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 713604024190 recombination protein RecR; Reviewed; Region: recR; PRK00076 713604024191 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 713604024192 RecR protein; Region: RecR; pfam02132 713604024193 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 713604024194 putative active site [active] 713604024195 putative metal-binding site [ion binding]; other site 713604024196 tetramer interface [polypeptide binding]; other site 713604024197 hypothetical protein; Validated; Region: PRK00153 713604024198 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 713604024199 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 713604024200 active site 713604024201 metal binding site [ion binding]; metal-binding site 713604024202 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604024203 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604024204 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604024205 HTH-like domain; Region: HTH_21; pfam13276 713604024206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 713604024207 Integrase core domain; Region: rve; pfam00665 713604024208 Integrase core domain; Region: rve_3; pfam13683 713604024209 Transposase; Region: HTH_Tnp_1; pfam01527 713604024210 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604024211 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 713604024212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604024213 Walker A motif; other site 713604024214 ATP binding site [chemical binding]; other site 713604024215 Walker B motif; other site 713604024216 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 713604024217 Short repeats of unknown function; Region: ALF; pfam03752 713604024218 Short repeats of unknown function; Region: ALF; pfam03752 713604024219 Short repeats of unknown function; Region: ALF; pfam03752 713604024220 Short repeats of unknown function; Region: ALF; pfam03752 713604024221 Short repeats of unknown function; Region: ALF; pfam03752 713604024222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604024223 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604024224 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604024225 G1 box; other site 713604024226 GTP/Mg2+ binding site [chemical binding]; other site 713604024227 G2 box; other site 713604024228 Switch I region; other site 713604024229 G3 box; other site 713604024230 Switch II region; other site 713604024231 G4 box; other site 713604024232 G5 box; other site 713604024233 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604024234 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 713604024235 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604024236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604024237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604024238 ATP binding site [chemical binding]; other site 713604024239 Mg2+ binding site [ion binding]; other site 713604024240 G-X-G motif; other site 713604024241 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604024242 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604024243 Walker A/P-loop; other site 713604024244 ATP binding site [chemical binding]; other site 713604024245 Q-loop/lid; other site 713604024246 ABC transporter signature motif; other site 713604024247 Walker B; other site 713604024248 D-loop; other site 713604024249 H-loop/switch region; other site 713604024250 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604024251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024252 dimer interface [polypeptide binding]; other site 713604024253 conserved gate region; other site 713604024254 putative PBP binding loops; other site 713604024255 ABC-ATPase subunit interface; other site 713604024256 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 713604024257 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 713604024258 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 713604024259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604024260 HAMP domain; Region: HAMP; pfam00672 713604024261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604024262 dimer interface [polypeptide binding]; other site 713604024263 phosphorylation site [posttranslational modification] 713604024264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604024265 ATP binding site [chemical binding]; other site 713604024266 Mg2+ binding site [ion binding]; other site 713604024267 G-X-G motif; other site 713604024268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604024269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604024270 active site 713604024271 phosphorylation site [posttranslational modification] 713604024272 intermolecular recognition site; other site 713604024273 dimerization interface [polypeptide binding]; other site 713604024274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604024275 DNA binding site [nucleotide binding] 713604024276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604024277 Histidine kinase; Region: HisKA_3; pfam07730 713604024278 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604024279 Mg2+ binding site [ion binding]; other site 713604024280 G-X-G motif; other site 713604024281 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604024282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604024283 active site 713604024284 phosphorylation site [posttranslational modification] 713604024285 intermolecular recognition site; other site 713604024286 dimerization interface [polypeptide binding]; other site 713604024287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604024288 DNA binding residues [nucleotide binding] 713604024289 dimerization interface [polypeptide binding]; other site 713604024290 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604024291 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604024292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024293 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 713604024294 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604024295 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604024296 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604024297 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604024298 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604024299 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 713604024300 LGFP repeat; Region: LGFP; pfam08310 713604024301 LGFP repeat; Region: LGFP; pfam08310 713604024302 LGFP repeat; Region: LGFP; pfam08310 713604024303 LGFP repeat; Region: LGFP; pfam08310 713604024304 LGFP repeat; Region: LGFP; pfam08310 713604024305 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604024306 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604024307 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604024308 active site 713604024309 ATP binding site [chemical binding]; other site 713604024310 substrate binding site [chemical binding]; other site 713604024311 activation loop (A-loop); other site 713604024312 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 713604024313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604024314 S-adenosylmethionine binding site [chemical binding]; other site 713604024315 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 713604024316 Protein phosphatase 2C; Region: PP2C; pfam00481 713604024317 active site 713604024318 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604024319 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 713604024320 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 713604024321 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 713604024322 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 713604024323 generic binding surface I; other site 713604024324 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 713604024325 putative active site [active] 713604024326 putative catalytic site [active] 713604024327 putative Mg binding site IVb [ion binding]; other site 713604024328 putative phosphate binding site [ion binding]; other site 713604024329 putative DNA binding site [nucleotide binding]; other site 713604024330 putative Mg binding site IVa [ion binding]; other site 713604024331 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 713604024332 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 713604024333 putative active site [active] 713604024334 putative metal binding site [ion binding]; other site 713604024335 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604024336 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 713604024337 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 713604024338 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604024339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604024340 NAD(P) binding site [chemical binding]; other site 713604024341 active site 713604024342 CsbD-like; Region: CsbD; pfam05532 713604024343 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 713604024344 nucleoside/Zn binding site; other site 713604024345 dimer interface [polypeptide binding]; other site 713604024346 catalytic motif [active] 713604024347 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 713604024348 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 713604024349 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 713604024350 metal binding site [ion binding]; metal-binding site 713604024351 dimer interface [polypeptide binding]; other site 713604024352 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 713604024353 Phosphoesterase family; Region: Phosphoesterase; pfam04185 713604024354 Domain of unknown function (DUF756); Region: DUF756; pfam05506 713604024355 Domain of unknown function (DUF756); Region: DUF756; pfam05506 713604024356 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604024357 active site 713604024358 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604024359 Domain of unknown function (DUF336); Region: DUF336; cl01249 713604024360 RibD C-terminal domain; Region: RibD_C; cl17279 713604024361 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604024362 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 713604024363 active site 713604024364 dimer interface [polypeptide binding]; other site 713604024365 motif 1; other site 713604024366 motif 2; other site 713604024367 motif 3; other site 713604024368 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 713604024369 anticodon binding site; other site 713604024370 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604024371 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604024372 DNA binding residues [nucleotide binding] 713604024373 dimer interface [polypeptide binding]; other site 713604024374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604024375 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 713604024376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024377 dimer interface [polypeptide binding]; other site 713604024378 conserved gate region; other site 713604024379 putative PBP binding loops; other site 713604024380 ABC-ATPase subunit interface; other site 713604024381 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 713604024382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604024383 Walker A/P-loop; other site 713604024384 ATP binding site [chemical binding]; other site 713604024385 Q-loop/lid; other site 713604024386 ABC transporter signature motif; other site 713604024387 Walker B; other site 713604024388 D-loop; other site 713604024389 H-loop/switch region; other site 713604024390 TOBE domain; Region: TOBE_2; pfam08402 713604024391 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 713604024392 hypothetical protein; Provisional; Region: PRK11622 713604024393 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 713604024394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604024395 DNA-binding site [nucleotide binding]; DNA binding site 713604024396 FCD domain; Region: FCD; pfam07729 713604024397 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 713604024398 inhibitor site; inhibition site 713604024399 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 713604024400 active site 713604024401 dimer interface [polypeptide binding]; other site 713604024402 catalytic residue [active] 713604024403 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 713604024404 putative di-iron ligands [ion binding]; other site 713604024405 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 713604024406 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 713604024407 active site 713604024408 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604024409 substrate binding site [chemical binding]; other site 713604024410 catalytic residues [active] 713604024411 dimer interface [polypeptide binding]; other site 713604024412 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604024413 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604024414 AsnC family; Region: AsnC_trans_reg; pfam01037 713604024415 Part of AAA domain; Region: AAA_19; pfam13245 713604024416 Family description; Region: UvrD_C_2; pfam13538 713604024417 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 713604024418 putative active site [active] 713604024419 putative metal binding site [ion binding]; other site 713604024420 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604024421 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604024422 intermolecular salt bridges; other site 713604024423 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604024424 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604024425 active site 713604024426 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604024427 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604024428 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604024429 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 713604024430 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 713604024431 FMN binding site [chemical binding]; other site 713604024432 active site 713604024433 catalytic residues [active] 713604024434 substrate binding site [chemical binding]; other site 713604024435 alpha-galactosidase; Region: PLN02808; cl17638 713604024436 alpha-galactosidase; Region: PLN02808; cl17638 713604024437 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604024438 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604024439 putative sugar binding sites [chemical binding]; other site 713604024440 Q-X-W motif; other site 713604024441 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604024442 DNA-binding site [nucleotide binding]; DNA binding site 713604024443 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604024444 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 713604024445 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 713604024446 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604024447 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604024448 substrate binding site [chemical binding]; other site 713604024449 ATP binding site [chemical binding]; other site 713604024450 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604024451 Isochorismatase family; Region: Isochorismatase; pfam00857 713604024452 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 713604024453 catalytic triad [active] 713604024454 conserved cis-peptide bond; other site 713604024455 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604024456 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604024457 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 713604024458 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 713604024459 active site 713604024460 metal binding site [ion binding]; metal-binding site 713604024461 nudix motif; other site 713604024462 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604024463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604024464 metal binding site [ion binding]; metal-binding site 713604024465 active site 713604024466 I-site; other site 713604024467 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 713604024468 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 713604024469 PhoU domain; Region: PhoU; pfam01895 713604024470 PhoU domain; Region: PhoU; pfam01895 713604024471 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 713604024472 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 713604024473 Walker A/P-loop; other site 713604024474 ATP binding site [chemical binding]; other site 713604024475 Q-loop/lid; other site 713604024476 ABC transporter signature motif; other site 713604024477 Walker B; other site 713604024478 D-loop; other site 713604024479 H-loop/switch region; other site 713604024480 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 713604024481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024482 dimer interface [polypeptide binding]; other site 713604024483 conserved gate region; other site 713604024484 putative PBP binding loops; other site 713604024485 ABC-ATPase subunit interface; other site 713604024486 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 713604024487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024488 dimer interface [polypeptide binding]; other site 713604024489 conserved gate region; other site 713604024490 putative PBP binding loops; other site 713604024491 ABC-ATPase subunit interface; other site 713604024492 PBP superfamily domain; Region: PBP_like_2; cl17296 713604024493 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 713604024494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604024495 Coenzyme A binding pocket [chemical binding]; other site 713604024496 DNA-binding response regulator CreB; Provisional; Region: PRK11083 713604024497 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604024498 DNA binding site [nucleotide binding] 713604024499 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 713604024500 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 713604024501 catalytic residues [active] 713604024502 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 713604024503 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 713604024504 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 713604024505 active site residue [active] 713604024506 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 713604024507 active site residue [active] 713604024508 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 713604024509 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 713604024510 heme-binding site [chemical binding]; other site 713604024511 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 713604024512 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 713604024513 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 713604024514 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 713604024515 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 713604024516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604024517 catalytic residue [active] 713604024518 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 713604024519 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 713604024520 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 713604024521 L-asparaginase II; Region: Asparaginase_II; pfam06089 713604024522 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 713604024523 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 713604024524 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604024525 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604024526 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604024527 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 713604024528 Walker A/P-loop; other site 713604024529 ATP binding site [chemical binding]; other site 713604024530 Q-loop/lid; other site 713604024531 ABC transporter signature motif; other site 713604024532 Walker B; other site 713604024533 D-loop; other site 713604024534 H-loop/switch region; other site 713604024535 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 713604024536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604024537 Walker A/P-loop; other site 713604024538 ATP binding site [chemical binding]; other site 713604024539 Q-loop/lid; other site 713604024540 ABC transporter signature motif; other site 713604024541 Walker B; other site 713604024542 D-loop; other site 713604024543 H-loop/switch region; other site 713604024544 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604024545 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604024546 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604024547 VanZ like family; Region: VanZ; cl01971 713604024548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604024549 Coenzyme A binding pocket [chemical binding]; other site 713604024550 hypothetical protein; Provisional; Region: PRK09256 713604024551 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 713604024552 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 713604024553 dimerization interface [polypeptide binding]; other site 713604024554 putative ATP binding site [chemical binding]; other site 713604024555 amidophosphoribosyltransferase; Provisional; Region: PRK07847 713604024556 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 713604024557 active site 713604024558 tetramer interface [polypeptide binding]; other site 713604024559 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604024560 active site 713604024561 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604024562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604024563 non-specific DNA binding site [nucleotide binding]; other site 713604024564 salt bridge; other site 713604024565 sequence-specific DNA binding site [nucleotide binding]; other site 713604024566 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604024567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604024568 S-adenosylmethionine binding site [chemical binding]; other site 713604024569 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 713604024570 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604024571 active site 713604024572 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 713604024573 active site 713604024574 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604024575 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 713604024576 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 713604024577 Helix-turn-helix domain; Region: HTH_38; pfam13936 713604024578 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 713604024579 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 713604024580 dimerization interface [polypeptide binding]; other site 713604024581 ATP binding site [chemical binding]; other site 713604024582 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 713604024583 dimerization interface [polypeptide binding]; other site 713604024584 ATP binding site [chemical binding]; other site 713604024585 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604024586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604024587 Walker A/P-loop; other site 713604024588 ATP binding site [chemical binding]; other site 713604024589 ABC transporter; Region: ABC_tran; pfam00005 713604024590 Q-loop/lid; other site 713604024591 ABC transporter signature motif; other site 713604024592 Walker B; other site 713604024593 D-loop; other site 713604024594 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604024595 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604024596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604024597 Walker A/P-loop; other site 713604024598 ATP binding site [chemical binding]; other site 713604024599 Q-loop/lid; other site 713604024600 ABC transporter signature motif; other site 713604024601 Walker B; other site 713604024602 D-loop; other site 713604024603 H-loop/switch region; other site 713604024604 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 713604024605 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 713604024606 putative active site [active] 713604024607 catalytic triad [active] 713604024608 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 713604024609 choline dehydrogenase; Validated; Region: PRK02106 713604024610 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604024611 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604024612 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 713604024613 NAD(P) binding site [chemical binding]; other site 713604024614 catalytic residues [active] 713604024615 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 713604024616 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604024617 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 713604024618 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 713604024619 Predicted flavoprotein [General function prediction only]; Region: COG0431 713604024620 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604024621 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 713604024622 ATP binding site [chemical binding]; other site 713604024623 active site 713604024624 substrate binding site [chemical binding]; other site 713604024625 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 713604024626 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 713604024627 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 713604024628 MOSC domain; Region: MOSC; pfam03473 713604024629 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 713604024630 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 713604024631 Walker A/P-loop; other site 713604024632 ATP binding site [chemical binding]; other site 713604024633 Q-loop/lid; other site 713604024634 ABC transporter signature motif; other site 713604024635 Walker B; other site 713604024636 D-loop; other site 713604024637 H-loop/switch region; other site 713604024638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024639 dimer interface [polypeptide binding]; other site 713604024640 conserved gate region; other site 713604024641 putative PBP binding loops; other site 713604024642 ABC-ATPase subunit interface; other site 713604024643 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604024644 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604024645 substrate binding pocket [chemical binding]; other site 713604024646 membrane-bound complex binding site; other site 713604024647 hinge residues; other site 713604024648 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604024649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604024650 substrate binding pocket [chemical binding]; other site 713604024651 membrane-bound complex binding site; other site 713604024652 hinge residues; other site 713604024653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604024654 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604024655 substrate binding pocket [chemical binding]; other site 713604024656 membrane-bound complex binding site; other site 713604024657 hinge residues; other site 713604024658 adenylosuccinate lyase; Region: purB; TIGR00928 713604024659 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 713604024660 tetramer interface [polypeptide binding]; other site 713604024661 galactonate dehydratase; Provisional; Region: PRK14017 713604024662 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 713604024663 metal binding site [ion binding]; metal-binding site 713604024664 substrate binding pocket [chemical binding]; other site 713604024665 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604024666 classical (c) SDRs; Region: SDR_c; cd05233 713604024667 NAD(P) binding site [chemical binding]; other site 713604024668 active site 713604024669 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 713604024670 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604024671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604024672 DNA-binding site [nucleotide binding]; DNA binding site 713604024673 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604024674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 713604024675 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604024676 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604024677 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604024678 DNA binding residues [nucleotide binding] 713604024679 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 713604024680 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604024681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604024682 catalytic residue [active] 713604024683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604024684 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604024685 aspartate aminotransferase; Provisional; Region: PRK05764 713604024686 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604024687 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604024688 homodimer interface [polypeptide binding]; other site 713604024689 catalytic residue [active] 713604024690 Proteins of 100 residues with WXG; Region: WXG100; cl02005 713604024691 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 713604024692 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604024693 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604024694 catalytic residue [active] 713604024695 EspG family; Region: ESX-1_EspG; pfam14011 713604024696 septum formation inhibitor; Reviewed; Region: minC; PRK03511 713604024697 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 713604024698 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 713604024699 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 713604024700 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 713604024701 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 713604024702 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 713604024703 putative active site [active] 713604024704 catalytic site [active] 713604024705 putative metal binding site [ion binding]; other site 713604024706 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604024707 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604024708 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 713604024709 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 713604024710 ligand binding site [chemical binding]; other site 713604024711 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604024712 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604024713 substrate binding site [chemical binding]; other site 713604024714 ATP binding site [chemical binding]; other site 713604024715 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 713604024716 dimerization interface [polypeptide binding]; other site 713604024717 active site 713604024718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024719 putative substrate translocation pore; other site 713604024720 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 713604024721 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 713604024722 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604024723 OsmC-like protein; Region: OsmC; pfam02566 713604024724 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 713604024725 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 713604024726 GDP-binding site [chemical binding]; other site 713604024727 ACT binding site; other site 713604024728 IMP binding site; other site 713604024729 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 713604024730 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604024731 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604024732 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 713604024733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024734 putative substrate translocation pore; other site 713604024735 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604024736 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604024737 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604024738 metal binding site [ion binding]; metal-binding site 713604024739 active site 713604024740 I-site; other site 713604024741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604024742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024743 Secretory lipase; Region: LIP; pfam03583 713604024744 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 713604024745 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 713604024746 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 713604024747 active site 713604024748 intersubunit interface [polypeptide binding]; other site 713604024749 zinc binding site [ion binding]; other site 713604024750 Na+ binding site [ion binding]; other site 713604024751 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604024752 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 713604024753 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604024754 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604024755 active site 713604024756 catalytic tetrad [active] 713604024757 short chain dehydrogenase; Provisional; Region: PRK05872 713604024758 classical (c) SDRs; Region: SDR_c; cd05233 713604024759 NAD(P) binding site [chemical binding]; other site 713604024760 active site 713604024761 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604024762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604024763 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 713604024764 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 713604024765 FMN-binding pocket [chemical binding]; other site 713604024766 flavin binding motif; other site 713604024767 phosphate binding motif [ion binding]; other site 713604024768 beta-alpha-beta structure motif; other site 713604024769 NAD binding pocket [chemical binding]; other site 713604024770 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604024771 catalytic loop [active] 713604024772 iron binding site [ion binding]; other site 713604024773 YCII-related domain; Region: YCII; cl00999 713604024774 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604024775 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604024776 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604024777 DNA binding residues [nucleotide binding] 713604024778 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 713604024779 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 713604024780 active site 713604024781 dimer interface [polypeptide binding]; other site 713604024782 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604024783 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604024784 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 713604024785 putative active site [active] 713604024786 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 713604024787 FAD binding domain; Region: FAD_binding_4; pfam01565 713604024788 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 713604024789 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604024790 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604024791 MarR family; Region: MarR; pfam01047 713604024792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024793 D-galactonate transporter; Region: 2A0114; TIGR00893 713604024794 putative substrate translocation pore; other site 713604024795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024796 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604024797 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604024798 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604024799 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604024800 YceI-like domain; Region: YceI; smart00867 713604024801 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604024802 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604024803 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604024804 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604024805 active site 713604024806 metal binding site [ion binding]; metal-binding site 713604024807 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 713604024808 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 713604024809 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 713604024810 short chain dehydrogenase; Provisional; Region: PRK06123 713604024811 classical (c) SDRs; Region: SDR_c; cd05233 713604024812 NAD(P) binding site [chemical binding]; other site 713604024813 active site 713604024814 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 713604024815 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 713604024816 active site 713604024817 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604024818 substrate binding site [chemical binding]; other site 713604024819 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604024820 ATP binding site [chemical binding]; other site 713604024821 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604024822 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604024823 Walker A/P-loop; other site 713604024824 ATP binding site [chemical binding]; other site 713604024825 Q-loop/lid; other site 713604024826 ABC transporter signature motif; other site 713604024827 Walker B; other site 713604024828 D-loop; other site 713604024829 H-loop/switch region; other site 713604024830 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604024831 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604024832 TM-ABC transporter signature motif; other site 713604024833 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 713604024834 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604024835 ligand binding site [chemical binding]; other site 713604024836 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604024837 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604024838 DNA binding site [nucleotide binding] 713604024839 domain linker motif; other site 713604024840 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604024841 ligand binding site [chemical binding]; other site 713604024842 dimerization interface [polypeptide binding]; other site 713604024843 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604024844 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604024845 ligand binding site [chemical binding]; other site 713604024846 dimerization interface [polypeptide binding]; other site 713604024847 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 713604024848 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 713604024849 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 713604024850 putative [Fe4-S4] binding site [ion binding]; other site 713604024851 putative molybdopterin cofactor binding site [chemical binding]; other site 713604024852 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 713604024853 putative molybdopterin cofactor binding site; other site 713604024854 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604024855 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 713604024856 Asp23 family; Region: Asp23; pfam03780 713604024857 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 713604024858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604024859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604024860 DNA binding residues [nucleotide binding] 713604024861 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604024862 active site 713604024863 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 713604024864 FtsX-like permease family; Region: FtsX; pfam02687 713604024865 FtsX-like permease family; Region: FtsX; pfam02687 713604024866 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604024867 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604024868 Walker A/P-loop; other site 713604024869 ATP binding site [chemical binding]; other site 713604024870 Q-loop/lid; other site 713604024871 ABC transporter signature motif; other site 713604024872 Walker B; other site 713604024873 D-loop; other site 713604024874 H-loop/switch region; other site 713604024875 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 713604024876 classical (c) SDRs; Region: SDR_c; cd05233 713604024877 NAD(P) binding site [chemical binding]; other site 713604024878 active site 713604024879 anthranilate synthase; Provisional; Region: PRK13566 713604024880 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 713604024881 Clp amino terminal domain; Region: Clp_N; pfam02861 713604024882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604024883 Walker A motif; other site 713604024884 ATP binding site [chemical binding]; other site 713604024885 Walker B motif; other site 713604024886 arginine finger; other site 713604024887 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 713604024888 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604024889 Walker A motif; other site 713604024890 ATP binding site [chemical binding]; other site 713604024891 Walker B motif; other site 713604024892 arginine finger; other site 713604024893 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 713604024894 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604024895 MarR family; Region: MarR_2; pfam12802 713604024896 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 713604024897 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 713604024898 heme-binding site [chemical binding]; other site 713604024899 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 713604024900 FAD binding pocket [chemical binding]; other site 713604024901 FAD binding motif [chemical binding]; other site 713604024902 phosphate binding motif [ion binding]; other site 713604024903 beta-alpha-beta structure motif; other site 713604024904 NAD binding pocket [chemical binding]; other site 713604024905 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 713604024906 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 713604024907 heme-binding site [chemical binding]; other site 713604024908 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 713604024909 FAD binding pocket [chemical binding]; other site 713604024910 FAD binding motif [chemical binding]; other site 713604024911 phosphate binding motif [ion binding]; other site 713604024912 beta-alpha-beta structure motif; other site 713604024913 NAD binding pocket [chemical binding]; other site 713604024914 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 713604024915 Chitin binding domain; Region: Chitin_bind_3; pfam03067 713604024916 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 713604024917 Domain of unknown function (DUF305); Region: DUF305; pfam03713 713604024918 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 713604024919 DNA binding residues [nucleotide binding] 713604024920 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604024921 putative dimer interface [polypeptide binding]; other site 713604024922 chaperone protein DnaJ; Provisional; Region: PRK14295 713604024923 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 713604024924 HSP70 interaction site [polypeptide binding]; other site 713604024925 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 713604024926 Zn binding sites [ion binding]; other site 713604024927 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 713604024928 dimer interface [polypeptide binding]; other site 713604024929 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 713604024930 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 713604024931 dimer interface [polypeptide binding]; other site 713604024932 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 713604024933 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 713604024934 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 713604024935 nucleotide binding site [chemical binding]; other site 713604024936 NEF interaction site [polypeptide binding]; other site 713604024937 SBD interface [polypeptide binding]; other site 713604024938 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604024939 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 713604024940 substrate binding site [chemical binding]; other site 713604024941 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604024942 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 713604024943 Coenzyme A binding pocket [chemical binding]; other site 713604024944 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 713604024945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024946 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 713604024947 Cysteine-rich domain; Region: CCG; pfam02754 713604024948 Cysteine-rich domain; Region: CCG; pfam02754 713604024949 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604024950 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 713604024951 Cation efflux family; Region: Cation_efflux; pfam01545 713604024952 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 713604024953 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 713604024954 Domain of unknown function DUF11; Region: DUF11; cl17728 713604024955 Domain of unknown function DUF11; Region: DUF11; pfam01345 713604024956 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604024957 MarR family; Region: MarR; pfam01047 713604024958 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604024959 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 713604024960 trimer interface [polypeptide binding]; other site 713604024961 active site 713604024962 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 713604024963 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604024964 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604024965 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604024966 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604024967 YCII-related domain; Region: YCII; cl00999 713604024968 Cytochrome P450; Region: p450; cl12078 713604024969 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604024970 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604024971 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604024972 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604024973 Protein of unknown function (DUF419); Region: DUF419; cl15265 713604024974 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 713604024975 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 713604024976 putative active site [active] 713604024977 putative metal binding site [ion binding]; other site 713604024978 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 713604024979 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604024980 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604024981 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604024982 VanZ like family; Region: VanZ; pfam04892 713604024983 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 713604024984 active site 713604024985 SUMO-1 interface [polypeptide binding]; other site 713604024986 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604024987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604024988 DNA binding residues [nucleotide binding] 713604024989 dimerization interface [polypeptide binding]; other site 713604024990 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 713604024991 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 713604024992 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 713604024993 FAD binding site [chemical binding]; other site 713604024994 substrate binding site [chemical binding]; other site 713604024995 catalytic residues [active] 713604024996 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 713604024997 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604024998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604024999 salt bridge; other site 713604025000 non-specific DNA binding site [nucleotide binding]; other site 713604025001 sequence-specific DNA binding site [nucleotide binding]; other site 713604025002 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 713604025003 Leucine rich repeat; Region: LRR_8; pfam13855 713604025004 Leucine-rich repeats; other site 713604025005 Substrate binding site [chemical binding]; other site 713604025006 Leucine rich repeat; Region: LRR_8; pfam13855 713604025007 Leucine rich repeat; Region: LRR_8; pfam13855 713604025008 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 713604025009 VanW like protein; Region: VanW; pfam04294 713604025010 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 713604025011 oligomerisation interface [polypeptide binding]; other site 713604025012 mobile loop; other site 713604025013 roof hairpin; other site 713604025014 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604025015 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 713604025016 NHL repeat; Region: NHL; pfam01436 713604025017 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604025018 hydrophobic ligand binding site; other site 713604025019 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 713604025020 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 713604025021 Walker A/P-loop; other site 713604025022 ATP binding site [chemical binding]; other site 713604025023 Q-loop/lid; other site 713604025024 ABC transporter signature motif; other site 713604025025 Walker B; other site 713604025026 D-loop; other site 713604025027 H-loop/switch region; other site 713604025028 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 713604025029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604025030 dimer interface [polypeptide binding]; other site 713604025031 conserved gate region; other site 713604025032 putative PBP binding loops; other site 713604025033 ABC-ATPase subunit interface; other site 713604025034 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604025035 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604025036 substrate binding pocket [chemical binding]; other site 713604025037 membrane-bound complex binding site; other site 713604025038 hinge residues; other site 713604025039 Uncharacterized conserved protein [Function unknown]; Region: COG2308 713604025040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 713604025041 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 713604025042 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 713604025043 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 713604025044 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 713604025045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604025046 NAD(P) binding site [chemical binding]; other site 713604025047 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604025048 hypothetical protein; Provisional; Region: PRK07907 713604025049 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 713604025050 metal binding site [ion binding]; metal-binding site 713604025051 putative dimer interface [polypeptide binding]; other site 713604025052 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 713604025053 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 713604025054 TPP-binding site [chemical binding]; other site 713604025055 heterodimer interface [polypeptide binding]; other site 713604025056 tetramer interface [polypeptide binding]; other site 713604025057 phosphorylation loop region [posttranslational modification] 713604025058 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 713604025059 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 713604025060 alpha subunit interface [polypeptide binding]; other site 713604025061 TPP binding site [chemical binding]; other site 713604025062 heterodimer interface [polypeptide binding]; other site 713604025063 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604025064 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 713604025065 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 713604025066 E3 interaction surface; other site 713604025067 lipoyl attachment site [posttranslational modification]; other site 713604025068 e3 binding domain; Region: E3_binding; pfam02817 713604025069 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 713604025070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604025071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604025072 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604025073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604025074 Walker A/P-loop; other site 713604025075 ATP binding site [chemical binding]; other site 713604025076 Q-loop/lid; other site 713604025077 ABC transporter signature motif; other site 713604025078 Walker B; other site 713604025079 D-loop; other site 713604025080 H-loop/switch region; other site 713604025081 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604025082 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604025083 NAD(P) binding site [chemical binding]; other site 713604025084 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604025085 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604025086 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 713604025087 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 713604025088 additional DNA contacts [nucleotide binding]; other site 713604025089 active site 713604025090 zinc binding site [ion binding]; other site 713604025091 DNA intercalation site [nucleotide binding]; other site 713604025092 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 713604025093 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 713604025094 cofactor binding site; other site 713604025095 DNA binding site [nucleotide binding] 713604025096 substrate interaction site [chemical binding]; other site 713604025097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604025098 ATP binding site [chemical binding]; other site 713604025099 putative Mg++ binding site [ion binding]; other site 713604025100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604025101 nucleotide binding region [chemical binding]; other site 713604025102 ATP-binding site [chemical binding]; other site 713604025103 SCP-2 sterol transfer family; Region: SCP2; pfam02036 713604025104 SCP-2 sterol transfer family; Region: SCP2; pfam02036 713604025105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604025106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604025107 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604025108 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604025109 active site 2 [active] 713604025110 active site 1 [active] 713604025111 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 713604025112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604025113 NAD(P) binding site [chemical binding]; other site 713604025114 active site 713604025115 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 713604025116 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604025117 dimer interface [polypeptide binding]; other site 713604025118 active site 713604025119 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604025120 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604025121 DNA binding residues [nucleotide binding] 713604025122 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 713604025123 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 713604025124 AAA ATPase domain; Region: AAA_16; pfam13191 713604025125 Archaeal ATPase; Region: Arch_ATPase; pfam01637 713604025126 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604025127 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604025128 putative Zn2+ binding site [ion binding]; other site 713604025129 putative DNA binding site [nucleotide binding]; other site 713604025130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604025131 Coenzyme A binding pocket [chemical binding]; other site 713604025132 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 713604025133 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604025134 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 713604025135 Na binding site [ion binding]; other site 713604025136 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 713604025137 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604025138 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604025139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604025140 sequence-specific DNA binding site [nucleotide binding]; other site 713604025141 salt bridge; other site 713604025142 Predicted acetyltransferase [General function prediction only]; Region: COG3393 713604025143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604025144 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 713604025145 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 713604025146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604025147 Walker A/P-loop; other site 713604025148 ATP binding site [chemical binding]; other site 713604025149 Q-loop/lid; other site 713604025150 ABC transporter signature motif; other site 713604025151 Walker B; other site 713604025152 D-loop; other site 713604025153 H-loop/switch region; other site 713604025154 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604025155 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604025156 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604025157 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604025158 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 713604025159 active site 713604025160 substrate-binding site [chemical binding]; other site 713604025161 metal-binding site [ion binding] 713604025162 GTP binding site [chemical binding]; other site 713604025163 Dynamin family; Region: Dynamin_N; pfam00350 713604025164 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604025165 G1 box; other site 713604025166 GTP/Mg2+ binding site [chemical binding]; other site 713604025167 G2 box; other site 713604025168 Switch I region; other site 713604025169 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604025170 G3 box; other site 713604025171 Switch II region; other site 713604025172 GTP/Mg2+ binding site [chemical binding]; other site 713604025173 G4 box; other site 713604025174 G5 box; other site 713604025175 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 713604025176 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 713604025177 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604025178 G1 box; other site 713604025179 GTP/Mg2+ binding site [chemical binding]; other site 713604025180 G2 box; other site 713604025181 Switch I region; other site 713604025182 G3 box; other site 713604025183 Switch II region; other site 713604025184 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604025185 Histidine kinase; Region: HisKA_3; pfam07730 713604025186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604025187 ATP binding site [chemical binding]; other site 713604025188 Mg2+ binding site [ion binding]; other site 713604025189 G-X-G motif; other site 713604025190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604025191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604025192 active site 713604025193 phosphorylation site [posttranslational modification] 713604025194 intermolecular recognition site; other site 713604025195 dimerization interface [polypeptide binding]; other site 713604025196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604025197 DNA binding residues [nucleotide binding] 713604025198 dimerization interface [polypeptide binding]; other site 713604025199 short chain dehydrogenase; Provisional; Region: PRK08303 713604025200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604025201 NAD(P) binding site [chemical binding]; other site 713604025202 active site 713604025203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604025204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604025205 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604025206 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 713604025207 Walker A/P-loop; other site 713604025208 ATP binding site [chemical binding]; other site 713604025209 Q-loop/lid; other site 713604025210 ABC transporter signature motif; other site 713604025211 Walker B; other site 713604025212 D-loop; other site 713604025213 H-loop/switch region; other site 713604025214 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604025215 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604025216 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 713604025217 Walker A/P-loop; other site 713604025218 ATP binding site [chemical binding]; other site 713604025219 Q-loop/lid; other site 713604025220 ABC transporter signature motif; other site 713604025221 Walker B; other site 713604025222 D-loop; other site 713604025223 H-loop/switch region; other site 713604025224 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604025225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604025226 S-adenosylmethionine binding site [chemical binding]; other site 713604025227 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604025228 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604025229 Walker A/P-loop; other site 713604025230 ATP binding site [chemical binding]; other site 713604025231 Q-loop/lid; other site 713604025232 ABC transporter signature motif; other site 713604025233 Walker B; other site 713604025234 D-loop; other site 713604025235 H-loop/switch region; other site 713604025236 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604025237 Histidine kinase; Region: HisKA_3; pfam07730 713604025238 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604025239 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604025240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604025241 active site 713604025242 phosphorylation site [posttranslational modification] 713604025243 intermolecular recognition site; other site 713604025244 dimerization interface [polypeptide binding]; other site 713604025245 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604025246 DNA binding residues [nucleotide binding] 713604025247 dimerization interface [polypeptide binding]; other site 713604025248 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 713604025249 active site 713604025250 putative substrate binding pocket [chemical binding]; other site 713604025251 short chain dehydrogenase; Provisional; Region: PRK08219 713604025252 classical (c) SDRs; Region: SDR_c; cd05233 713604025253 NAD(P) binding site [chemical binding]; other site 713604025254 active site 713604025255 Domain of unknown function DUF11; Region: DUF11; pfam01345 713604025256 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604025257 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 713604025258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604025259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604025260 putative substrate translocation pore; other site 713604025261 MarR family; Region: MarR; pfam01047 713604025262 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 713604025263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604025264 motif II; other site 713604025265 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604025266 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604025267 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604025268 DNA binding residues [nucleotide binding] 713604025269 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 713604025270 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 713604025271 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604025272 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604025273 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 713604025274 Transglycosylase; Region: Transgly; pfam00912 713604025275 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604025276 Transglycosylase; Region: Transgly; pfam00912 713604025277 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 713604025278 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604025279 putative oxidoreductase; Provisional; Region: PRK11579 713604025280 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604025281 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604025282 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604025283 MarR family; Region: MarR_2; pfam12802 713604025284 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604025285 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604025286 Predicted integral membrane protein [Function unknown]; Region: COG5650 713604025287 endonuclease IV; Provisional; Region: PRK01060 713604025288 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 713604025289 AP (apurinic/apyrimidinic) site pocket; other site 713604025290 DNA interaction; other site 713604025291 Metal-binding active site; metal-binding site 713604025292 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 713604025293 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 713604025294 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 713604025295 dimer interface [polypeptide binding]; other site 713604025296 ssDNA binding site [nucleotide binding]; other site 713604025297 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604025298 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 713604025299 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 713604025300 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 713604025301 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 713604025302 EspG family; Region: ESX-1_EspG; pfam14011 713604025303 replicative DNA helicase; Region: DnaB; TIGR00665 713604025304 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 713604025305 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 713604025306 Walker A motif; other site 713604025307 ATP binding site [chemical binding]; other site 713604025308 Walker B motif; other site 713604025309 DNA binding loops [nucleotide binding] 713604025310 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604025311 MarR family; Region: MarR_2; pfam12802 713604025312 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604025313 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 713604025314 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 713604025315 putative active site [active] 713604025316 metal binding site [ion binding]; metal-binding site 713604025317 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 713604025318 Domain of unknown function DUF20; Region: UPF0118; pfam01594 713604025319 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604025320 ATP binding site [chemical binding]; other site 713604025321 G-X-G motif; other site 713604025322 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604025323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604025324 active site 713604025325 phosphorylation site [posttranslational modification] 713604025326 intermolecular recognition site; other site 713604025327 dimerization interface [polypeptide binding]; other site 713604025328 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604025329 DNA binding residues [nucleotide binding] 713604025330 dimerization interface [polypeptide binding]; other site 713604025331 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604025332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604025333 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 713604025334 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 713604025335 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 713604025336 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 713604025337 ParB-like nuclease domain; Region: ParBc; cl02129 713604025338 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 713604025339 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604025340 substrate binding site [chemical binding]; other site 713604025341 dimer interface [polypeptide binding]; other site 713604025342 ATP binding site [chemical binding]; other site 713604025343 EspG family; Region: ESX-1_EspG; pfam14011 713604025344 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 713604025345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604025346 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 713604025347 DNA-binding interface [nucleotide binding]; DNA binding site 713604025348 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604025349 classical (c) SDRs; Region: SDR_c; cd05233 713604025350 NAD(P) binding site [chemical binding]; other site 713604025351 active site 713604025352 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 713604025353 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604025354 active site 713604025355 HIGH motif; other site 713604025356 nucleotide binding site [chemical binding]; other site 713604025357 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 713604025358 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604025359 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604025360 active site 713604025361 KMSKS motif; other site 713604025362 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 713604025363 tRNA binding surface [nucleotide binding]; other site 713604025364 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 713604025365 SdpI/YhfL protein family; Region: SdpI; pfam13630 713604025366 hypothetical protein; Validated; Region: PRK00228 713604025367 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604025368 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 713604025369 active site 713604025370 conformational flexibility of ligand binding pocket; other site 713604025371 ADP-ribosylating toxin turn-turn motif; other site 713604025372 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 713604025373 Region found in RelA / SpoT proteins; Region: RelA_SpoT; smart00954 713604025374 metal binding triad [ion binding]; metal-binding site 713604025375 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 713604025376 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 713604025377 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 713604025378 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 713604025379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604025380 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604025381 ATP binding site [chemical binding]; other site 713604025382 Mg2+ binding site [ion binding]; other site 713604025383 G-X-G motif; other site 713604025384 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 713604025385 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 713604025386 active site 713604025387 NTP binding site [chemical binding]; other site 713604025388 metal binding triad [ion binding]; metal-binding site 713604025389 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 713604025390 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604025391 Zn2+ binding site [ion binding]; other site 713604025392 Mg2+ binding site [ion binding]; other site 713604025393 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 713604025394 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 713604025395 active site 713604025396 Ap6A binding site [chemical binding]; other site 713604025397 nudix motif; other site 713604025398 metal binding site [ion binding]; metal-binding site 713604025399 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 713604025400 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 713604025401 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604025402 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604025403 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604025404 DNA binding residues [nucleotide binding] 713604025405 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 713604025406 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604025407 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604025408 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 713604025409 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 713604025410 catalytic residues [active] 713604025411 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 713604025412 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604025413 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604025414 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 713604025415 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 713604025416 active site 713604025417 metal binding site [ion binding]; metal-binding site 713604025418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604025419 Coenzyme A binding pocket [chemical binding]; other site 713604025420 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 713604025421 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604025422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604025423 homodimer interface [polypeptide binding]; other site 713604025424 catalytic residue [active] 713604025425 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 713604025426 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 713604025427 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604025428 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 713604025429 ParB-like nuclease domain; Region: ParBc; pfam02195 713604025430 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 713604025431 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604025432 P-loop; other site 713604025433 Magnesium ion binding site [ion binding]; other site 713604025434 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604025435 Magnesium ion binding site [ion binding]; other site 713604025436 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 713604025437 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 713604025438 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 713604025439 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 713604025440 G-X-X-G motif; other site 713604025441 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 713604025442 RxxxH motif; other site 713604025443 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 713604025444 Haemolytic domain; Region: Haemolytic; pfam01809 713604025445 Ribosomal protein L34; Region: Ribosomal_L34; cl00370