-- dump date 20140618_202958 -- class Genbank::misc_feature -- table misc_feature_note -- id note 713604000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604000002 Walker A motif; other site 713604000003 ATP binding site [chemical binding]; other site 713604000004 Walker B motif; other site 713604000005 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 713604000006 DnaA box-binding interface [nucleotide binding]; other site 713604000007 DNA polymerase III subunit beta; Validated; Region: PRK07761 713604000008 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 713604000009 putative DNA binding surface [nucleotide binding]; other site 713604000010 dimer interface [polypeptide binding]; other site 713604000011 beta-clamp/clamp loader binding surface; other site 713604000012 beta-clamp/translesion DNA polymerase binding surface; other site 713604000013 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 713604000014 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604000015 recombination protein F; Reviewed; Region: recF; PRK00064 713604000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 713604000017 Walker A/P-loop; other site 713604000018 ATP binding site [chemical binding]; other site 713604000019 Q-loop/lid; other site 713604000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604000021 ABC transporter signature motif; other site 713604000022 Walker B; other site 713604000023 D-loop; other site 713604000024 H-loop/switch region; other site 713604000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 713604000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 713604000027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 713604000028 anchoring element; other site 713604000029 dimer interface [polypeptide binding]; other site 713604000030 ATP binding site [chemical binding]; other site 713604000031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 713604000032 active site 713604000033 putative metal-binding site [ion binding]; other site 713604000034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 713604000035 DNA gyrase subunit A; Validated; Region: PRK05560 713604000036 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 713604000037 CAP-like domain; other site 713604000038 active site 713604000039 primary dimer interface [polypeptide binding]; other site 713604000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604000046 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 713604000047 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604000048 active site 713604000049 DNA binding site [nucleotide binding] 713604000050 Int/Topo IB signature motif; other site 713604000051 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604000052 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 713604000053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604000054 non-specific DNA binding site [nucleotide binding]; other site 713604000055 salt bridge; other site 713604000056 sequence-specific DNA binding site [nucleotide binding]; other site 713604000057 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604000058 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604000059 non-specific DNA binding site [nucleotide binding]; other site 713604000060 salt bridge; other site 713604000061 sequence-specific DNA binding site [nucleotide binding]; other site 713604000062 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604000063 active site 713604000064 metal binding site [ion binding]; metal-binding site 713604000065 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604000066 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 713604000067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604000068 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604000069 Walker A/P-loop; other site 713604000070 ATP binding site [chemical binding]; other site 713604000071 Q-loop/lid; other site 713604000072 ABC transporter signature motif; other site 713604000073 Walker B; other site 713604000074 D-loop; other site 713604000075 H-loop/switch region; other site 713604000076 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604000077 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604000078 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604000079 DNA binding site [nucleotide binding] 713604000080 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604000081 Predicted ATPase [General function prediction only]; Region: COG3903 713604000082 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604000083 Cytochrome P450; Region: p450; cl12078 713604000084 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 713604000085 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 713604000086 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604000087 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 713604000088 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 713604000089 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 713604000090 active site 713604000091 Rhomboid family; Region: Rhomboid; pfam01694 713604000092 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 713604000093 putative septation inhibitor protein; Reviewed; Region: PRK00159 713604000094 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 713604000095 active site 713604000096 catalytic site [active] 713604000097 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604000098 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604000099 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 713604000100 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604000101 Walker A/P-loop; other site 713604000102 ATP binding site [chemical binding]; other site 713604000103 Q-loop/lid; other site 713604000104 ABC transporter signature motif; other site 713604000105 Walker B; other site 713604000106 D-loop; other site 713604000107 H-loop/switch region; other site 713604000108 Putative sensor; Region: Sensor; pfam13796 713604000109 Histidine kinase; Region: HisKA_3; pfam07730 713604000110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604000111 ATP binding site [chemical binding]; other site 713604000112 Mg2+ binding site [ion binding]; other site 713604000113 G-X-G motif; other site 713604000114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604000115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604000116 active site 713604000117 phosphorylation site [posttranslational modification] 713604000118 intermolecular recognition site; other site 713604000119 dimerization interface [polypeptide binding]; other site 713604000120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604000121 DNA binding residues [nucleotide binding] 713604000122 dimerization interface [polypeptide binding]; other site 713604000123 ferredoxin-NADP+ reductase; Region: PLN02852 713604000124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604000125 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 713604000126 Glutamine amidotransferase class-I; Region: GATase; pfam00117 713604000127 glutamine binding [chemical binding]; other site 713604000128 catalytic triad [active] 713604000129 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604000130 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604000131 Walker A/P-loop; other site 713604000132 ATP binding site [chemical binding]; other site 713604000133 Q-loop/lid; other site 713604000134 ABC transporter signature motif; other site 713604000135 Walker B; other site 713604000136 D-loop; other site 713604000137 H-loop/switch region; other site 713604000138 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 713604000139 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604000140 active site 713604000141 ATP binding site [chemical binding]; other site 713604000142 substrate binding site [chemical binding]; other site 713604000143 activation loop (A-loop); other site 713604000144 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604000145 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604000146 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604000147 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604000148 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604000149 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604000150 active site 713604000151 ATP binding site [chemical binding]; other site 713604000152 substrate binding site [chemical binding]; other site 713604000153 activation loop (A-loop); other site 713604000154 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 713604000155 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 713604000156 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 713604000157 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 713604000158 active site 713604000159 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 713604000160 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 713604000161 phosphopeptide binding site; other site 713604000162 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 713604000163 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 713604000164 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 713604000165 phosphopeptide binding site; other site 713604000166 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604000167 cleavage site 713604000168 active site 713604000169 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604000170 active site 713604000171 substrate binding sites [chemical binding]; other site 713604000172 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 713604000173 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604000174 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604000175 active site 713604000176 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604000177 sugar binding site [chemical binding]; other site 713604000178 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 713604000179 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604000180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604000181 catalytic residue [active] 713604000182 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604000183 active site 713604000184 putative catalytic site [active] 713604000185 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 713604000186 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604000187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604000188 DNA-binding site [nucleotide binding]; DNA binding site 713604000189 FCD domain; Region: FCD; pfam07729 713604000190 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 713604000191 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 713604000192 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604000193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604000194 dimer interface [polypeptide binding]; other site 713604000195 conserved gate region; other site 713604000196 putative PBP binding loops; other site 713604000197 ABC-ATPase subunit interface; other site 713604000198 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604000199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604000200 dimer interface [polypeptide binding]; other site 713604000201 conserved gate region; other site 713604000202 putative PBP binding loops; other site 713604000203 ABC-ATPase subunit interface; other site 713604000204 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 713604000205 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604000206 Walker A/P-loop; other site 713604000207 ATP binding site [chemical binding]; other site 713604000208 Q-loop/lid; other site 713604000209 ABC transporter signature motif; other site 713604000210 Walker B; other site 713604000211 D-loop; other site 713604000212 H-loop/switch region; other site 713604000213 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604000214 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 713604000215 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604000216 Walker A/P-loop; other site 713604000217 ATP binding site [chemical binding]; other site 713604000218 Q-loop/lid; other site 713604000219 ABC transporter signature motif; other site 713604000220 Walker B; other site 713604000221 D-loop; other site 713604000222 H-loop/switch region; other site 713604000223 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604000224 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604000225 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604000226 NAD(P) binding site [chemical binding]; other site 713604000227 catalytic residues [active] 713604000228 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 713604000229 classical (c) SDRs; Region: SDR_c; cd05233 713604000230 NAD(P) binding site [chemical binding]; other site 713604000231 active site 713604000232 amidase; Provisional; Region: PRK07042 713604000233 Amidase; Region: Amidase; cl11426 713604000234 Transposase; Region: DEDD_Tnp_IS110; pfam01548 713604000235 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 713604000236 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 713604000237 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604000238 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000239 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604000240 DNA binding residues [nucleotide binding] 713604000241 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 713604000242 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 713604000243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604000244 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604000245 NAD(P) binding site [chemical binding]; other site 713604000246 active site 713604000247 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 713604000248 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 713604000249 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604000250 active site 713604000251 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 713604000252 FAD binding domain; Region: FAD_binding_4; pfam01565 713604000253 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 713604000254 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 713604000255 dimer interface [polypeptide binding]; other site 713604000256 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 713604000257 active site 713604000258 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604000259 substrate binding site [chemical binding]; other site 713604000260 catalytic residue [active] 713604000261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604000262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604000263 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604000264 beta-galactosidase; Region: BGL; TIGR03356 713604000265 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604000266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604000267 salt bridge; other site 713604000268 non-specific DNA binding site [nucleotide binding]; other site 713604000269 sequence-specific DNA binding site [nucleotide binding]; other site 713604000270 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604000271 Phosphotransferase enzyme family; Region: APH; pfam01636 713604000272 active site 713604000273 ATP binding site [chemical binding]; other site 713604000274 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604000275 Copper resistance protein D; Region: CopD; pfam05425 713604000276 CopC domain; Region: CopC; pfam04234 713604000277 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 713604000278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604000279 putative PBP binding loops; other site 713604000280 dimer interface [polypeptide binding]; other site 713604000281 ABC-ATPase subunit interface; other site 713604000282 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 713604000283 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 713604000284 Walker A/P-loop; other site 713604000285 ATP binding site [chemical binding]; other site 713604000286 Q-loop/lid; other site 713604000287 ABC transporter signature motif; other site 713604000288 Walker B; other site 713604000289 D-loop; other site 713604000290 H-loop/switch region; other site 713604000291 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 713604000292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604000293 dimer interface [polypeptide binding]; other site 713604000294 conserved gate region; other site 713604000295 putative PBP binding loops; other site 713604000296 ABC-ATPase subunit interface; other site 713604000297 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 713604000298 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 713604000299 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 713604000300 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604000301 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604000302 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604000303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604000304 S-adenosylmethionine binding site [chemical binding]; other site 713604000305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604000306 NAD(P) binding site [chemical binding]; other site 713604000307 active site 713604000308 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 713604000309 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 713604000310 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 713604000311 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604000312 active site 713604000313 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 713604000314 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 713604000315 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604000316 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604000317 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 713604000318 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604000319 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 713604000320 putative dimer interface [polypeptide binding]; other site 713604000321 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604000322 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604000323 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604000324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000325 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604000326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604000327 putative substrate translocation pore; other site 713604000328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604000329 salt bridge; other site 713604000330 non-specific DNA binding site [nucleotide binding]; other site 713604000331 sequence-specific DNA binding site [nucleotide binding]; other site 713604000332 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604000333 Histidine kinase; Region: HisKA_3; pfam07730 713604000334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604000335 ATP binding site [chemical binding]; other site 713604000336 Mg2+ binding site [ion binding]; other site 713604000337 G-X-G motif; other site 713604000338 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604000339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604000340 active site 713604000341 phosphorylation site [posttranslational modification] 713604000342 intermolecular recognition site; other site 713604000343 dimerization interface [polypeptide binding]; other site 713604000344 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604000345 DNA binding residues [nucleotide binding] 713604000346 dimerization interface [polypeptide binding]; other site 713604000347 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 713604000348 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 713604000349 NADP-binding site; other site 713604000350 homotetramer interface [polypeptide binding]; other site 713604000351 substrate binding site [chemical binding]; other site 713604000352 homodimer interface [polypeptide binding]; other site 713604000353 active site 713604000354 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 713604000355 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604000356 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604000357 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604000358 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604000359 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604000360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604000361 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604000362 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 713604000363 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604000364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000365 Putative zinc-finger; Region: zf-HC2; pfam13490 713604000366 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 713604000367 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 713604000368 putative DNA binding site [nucleotide binding]; other site 713604000369 catalytic residue [active] 713604000370 putative H2TH interface [polypeptide binding]; other site 713604000371 putative catalytic residues [active] 713604000372 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604000373 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 713604000374 Histidine kinase; Region: His_kinase; pfam06580 713604000375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604000376 ATP binding site [chemical binding]; other site 713604000377 Mg2+ binding site [ion binding]; other site 713604000378 G-X-G motif; other site 713604000379 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 713604000380 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 713604000381 tandem repeat interface [polypeptide binding]; other site 713604000382 oligomer interface [polypeptide binding]; other site 713604000383 active site residues [active] 713604000384 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 713604000385 active site 713604000386 catalytic residues [active] 713604000387 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 713604000388 metal binding site [ion binding]; metal-binding site 713604000389 ligand binding site [chemical binding]; other site 713604000390 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 713604000391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604000392 active site 713604000393 phosphorylation site [posttranslational modification] 713604000394 intermolecular recognition site; other site 713604000395 dimerization interface [polypeptide binding]; other site 713604000396 LytTr DNA-binding domain; Region: LytTR; smart00850 713604000397 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604000398 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604000399 Na binding site [ion binding]; other site 713604000400 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 713604000401 active site residue [active] 713604000402 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 713604000403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604000404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604000405 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604000406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604000407 putative substrate translocation pore; other site 713604000408 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 713604000409 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604000410 Cytochrome P450; Region: p450; cl12078 713604000411 Protein of unknown function (DUF952); Region: DUF952; pfam06108 713604000412 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604000413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000414 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604000415 DNA binding residues [nucleotide binding] 713604000416 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 713604000417 Ferritin-like domain; Region: Ferritin; pfam00210 713604000418 ferroxidase diiron center [ion binding]; other site 713604000419 arginine deiminase; Provisional; Region: PRK01388 713604000420 CAAX protease self-immunity; Region: Abi; pfam02517 713604000421 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604000422 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 713604000423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604000424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604000425 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 713604000426 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604000427 metal ion-dependent adhesion site (MIDAS); other site 713604000428 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 713604000429 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604000430 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 713604000431 Protein of unknown function (DUF998); Region: DUF998; pfam06197 713604000432 Predicted membrane protein [Function unknown]; Region: COG2119 713604000433 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 713604000434 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 713604000435 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 713604000436 active site triad [active] 713604000437 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 713604000438 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 713604000439 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 713604000440 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 713604000441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604000442 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 713604000443 Walker A/P-loop; other site 713604000444 ATP binding site [chemical binding]; other site 713604000445 ABC transporter; Region: ABC_tran; pfam00005 713604000446 Q-loop/lid; other site 713604000447 ABC transporter signature motif; other site 713604000448 Walker B; other site 713604000449 D-loop; other site 713604000450 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 713604000451 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 713604000452 Walker A/P-loop; other site 713604000453 ATP binding site [chemical binding]; other site 713604000454 Q-loop/lid; other site 713604000455 ABC transporter signature motif; other site 713604000456 Walker B; other site 713604000457 D-loop; other site 713604000458 H-loop/switch region; other site 713604000459 GAF domain; Region: GAF; cl17456 713604000460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604000461 Histidine kinase; Region: HisKA_3; pfam07730 713604000462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604000463 ATP binding site [chemical binding]; other site 713604000464 Mg2+ binding site [ion binding]; other site 713604000465 G-X-G motif; other site 713604000466 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604000467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604000468 active site 713604000469 phosphorylation site [posttranslational modification] 713604000470 intermolecular recognition site; other site 713604000471 dimerization interface [polypeptide binding]; other site 713604000472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604000473 DNA binding residues [nucleotide binding] 713604000474 dimerization interface [polypeptide binding]; other site 713604000475 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 713604000476 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604000477 active site 713604000478 putative catalytic site [active] 713604000479 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 713604000480 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 713604000481 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 713604000482 active site 713604000483 catalytic site [active] 713604000484 substrate binding site [chemical binding]; other site 713604000485 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 713604000486 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 713604000487 homodimer interface [polypeptide binding]; other site 713604000488 chemical substrate binding site [chemical binding]; other site 713604000489 oligomer interface [polypeptide binding]; other site 713604000490 metal binding site [ion binding]; metal-binding site 713604000491 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604000492 pantothenate kinase; Provisional; Region: PRK05439 713604000493 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 713604000494 ATP-binding site [chemical binding]; other site 713604000495 CoA-binding site [chemical binding]; other site 713604000496 Mg2+-binding site [ion binding]; other site 713604000497 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 713604000498 ADP-ribose binding site [chemical binding]; other site 713604000499 prephenate dehydratase; Provisional; Region: PRK11898 713604000500 Prephenate dehydratase; Region: PDT; pfam00800 713604000501 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 713604000502 putative L-Phe binding site [chemical binding]; other site 713604000503 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604000504 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604000505 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 713604000506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604000507 putative substrate translocation pore; other site 713604000508 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 713604000509 Septum formation; Region: Septum_form; pfam13845 713604000510 Septum formation; Region: Septum_form; pfam13845 713604000511 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 713604000512 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 713604000513 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 713604000514 haloalkane dehalogenase; Provisional; Region: PRK00870 713604000515 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 713604000516 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604000517 inhibitor-cofactor binding pocket; inhibition site 713604000518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604000519 catalytic residue [active] 713604000520 seryl-tRNA synthetase; Provisional; Region: PRK05431 713604000521 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 713604000522 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 713604000523 dimer interface [polypeptide binding]; other site 713604000524 active site 713604000525 motif 1; other site 713604000526 motif 2; other site 713604000527 motif 3; other site 713604000528 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 713604000529 Predicted dehydrogenase [General function prediction only]; Region: COG0579 713604000530 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604000531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604000532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604000533 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604000534 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604000535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604000536 non-specific DNA binding site [nucleotide binding]; other site 713604000537 salt bridge; other site 713604000538 sequence-specific DNA binding site [nucleotide binding]; other site 713604000539 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604000540 DNA binding site [nucleotide binding] 713604000541 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604000542 AAA ATPase domain; Region: AAA_16; pfam13191 713604000543 Predicted ATPase [General function prediction only]; Region: COG3903 713604000544 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 713604000545 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 713604000546 inhibitor-cofactor binding pocket; inhibition site 713604000547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604000548 catalytic residue [active] 713604000549 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604000550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604000551 NAD(P) binding site [chemical binding]; other site 713604000552 active site 713604000553 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604000554 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604000555 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 713604000556 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 713604000557 trimer interface [polypeptide binding]; other site 713604000558 active site 713604000559 substrate binding site [chemical binding]; other site 713604000560 CoA binding site [chemical binding]; other site 713604000561 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604000562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000563 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604000564 DNA binding residues [nucleotide binding] 713604000565 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 713604000566 Peptidase family M28; Region: Peptidase_M28; pfam04389 713604000567 putative metal binding site [ion binding]; other site 713604000568 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604000569 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604000570 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604000571 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 713604000572 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 713604000573 inhibitor-cofactor binding pocket; inhibition site 713604000574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604000575 catalytic residue [active] 713604000576 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604000577 putative trimer interface [polypeptide binding]; other site 713604000578 putative CoA binding site [chemical binding]; other site 713604000579 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 713604000580 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604000581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604000582 NAD(P) binding site [chemical binding]; other site 713604000583 active site 713604000584 AMP-binding enzyme; Region: AMP-binding; pfam00501 713604000585 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604000586 acyl-activating enzyme (AAE) consensus motif; other site 713604000587 AMP binding site [chemical binding]; other site 713604000588 active site 713604000589 CoA binding site [chemical binding]; other site 713604000590 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 713604000591 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604000592 NAD(P) binding site [chemical binding]; other site 713604000593 catalytic residues [active] 713604000594 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 713604000595 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604000596 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604000597 putative acyl-acceptor binding pocket; other site 713604000598 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 713604000599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604000600 active site 713604000601 motif I; other site 713604000602 motif II; other site 713604000603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604000604 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604000605 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604000606 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 713604000607 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604000608 UDP-galactopyranose mutase; Region: GLF; pfam03275 713604000609 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 713604000610 active site 713604000611 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 713604000612 short chain dehydrogenase; Provisional; Region: PRK07904 713604000613 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 713604000614 NAD(P) binding site [chemical binding]; other site 713604000615 active site 713604000616 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604000617 FAD binding domain; Region: FAD_binding_4; pfam01565 713604000618 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 713604000619 Predicted membrane protein [Function unknown]; Region: COG2246 713604000620 GtrA-like protein; Region: GtrA; pfam04138 713604000621 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604000622 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604000623 active site 713604000624 EspG family; Region: ESX-1_EspG; pfam14011 713604000625 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604000626 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604000627 active site 713604000628 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 713604000629 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 713604000630 Walker A/P-loop; other site 713604000631 ATP binding site [chemical binding]; other site 713604000632 Q-loop/lid; other site 713604000633 ABC transporter signature motif; other site 713604000634 Walker B; other site 713604000635 D-loop; other site 713604000636 H-loop/switch region; other site 713604000637 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 713604000638 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604000639 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 713604000640 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604000641 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604000642 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604000643 catalytic residue [active] 713604000644 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 713604000645 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 713604000646 NAD(P) binding site [chemical binding]; other site 713604000647 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 713604000648 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 713604000649 PA/protease or protease-like domain interface [polypeptide binding]; other site 713604000650 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 713604000651 Peptidase family M28; Region: Peptidase_M28; pfam04389 713604000652 active site 713604000653 metal binding site [ion binding]; metal-binding site 713604000654 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604000655 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604000656 MarR family; Region: MarR; pfam01047 713604000657 MarR family; Region: MarR_2; cl17246 713604000658 Patatin-like phospholipase; Region: Patatin; pfam01734 713604000659 nucleophile elbow; other site 713604000660 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604000661 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604000662 active site 713604000663 metal binding site [ion binding]; metal-binding site 713604000664 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 713604000665 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 713604000666 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713604000667 RNA binding surface [nucleotide binding]; other site 713604000668 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 713604000669 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604000670 classical (c) SDRs; Region: SDR_c; cd05233 713604000671 NAD(P) binding site [chemical binding]; other site 713604000672 active site 713604000673 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 713604000674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604000675 active site 713604000676 phosphorylation site [posttranslational modification] 713604000677 intermolecular recognition site; other site 713604000678 dimerization interface [polypeptide binding]; other site 713604000679 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 713604000680 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 713604000681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604000682 Mg2+ binding site [ion binding]; other site 713604000683 G-X-G motif; other site 713604000684 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604000685 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604000686 Walker A/P-loop; other site 713604000687 ATP binding site [chemical binding]; other site 713604000688 Q-loop/lid; other site 713604000689 ABC transporter signature motif; other site 713604000690 Walker B; other site 713604000691 D-loop; other site 713604000692 H-loop/switch region; other site 713604000693 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604000694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604000695 dimer interface [polypeptide binding]; other site 713604000696 conserved gate region; other site 713604000697 putative PBP binding loops; other site 713604000698 ABC-ATPase subunit interface; other site 713604000699 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 713604000700 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604000701 substrate binding pocket [chemical binding]; other site 713604000702 membrane-bound complex binding site; other site 713604000703 hinge residues; other site 713604000704 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 713604000705 polypeptide substrate binding site [polypeptide binding]; other site 713604000706 active site 713604000707 AAA ATPase domain; Region: AAA_16; pfam13191 713604000708 Predicted ATPase [General function prediction only]; Region: COG3899 713604000709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604000710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604000711 DNA binding residues [nucleotide binding] 713604000712 dimerization interface [polypeptide binding]; other site 713604000713 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 713604000714 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 713604000715 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604000716 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604000717 putative DNA binding site [nucleotide binding]; other site 713604000718 putative Zn2+ binding site [ion binding]; other site 713604000719 AsnC family; Region: AsnC_trans_reg; pfam01037 713604000720 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 713604000721 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 713604000722 dimer interface [polypeptide binding]; other site 713604000723 active site 713604000724 CoA binding pocket [chemical binding]; other site 713604000725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604000726 dimerization interface [polypeptide binding]; other site 713604000727 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 713604000728 cyclase homology domain; Region: CHD; cd07302 713604000729 nucleotidyl binding site; other site 713604000730 metal binding site [ion binding]; metal-binding site 713604000731 dimer interface [polypeptide binding]; other site 713604000732 Leucine carboxyl methyltransferase; Region: LCM; cl01306 713604000733 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604000734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604000735 DNA-binding site [nucleotide binding]; DNA binding site 713604000736 FCD domain; Region: FCD; pfam07729 713604000737 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 713604000738 hypothetical protein; Provisional; Region: PRK10621 713604000739 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 713604000740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604000741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604000742 homodimer interface [polypeptide binding]; other site 713604000743 catalytic residue [active] 713604000744 Dienelactone hydrolase family; Region: DLH; pfam01738 713604000745 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 713604000746 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604000747 acyl-activating enzyme (AAE) consensus motif; other site 713604000748 AMP binding site [chemical binding]; other site 713604000749 active site 713604000750 CoA binding site [chemical binding]; other site 713604000751 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 713604000752 Cellulose binding domain; Region: CBM_2; pfam00553 713604000753 Glyco_18 domain; Region: Glyco_18; smart00636 713604000754 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 713604000755 active site 713604000756 Cellulose binding domain; Region: CBM_2; pfam00553 713604000757 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 713604000758 active site 713604000759 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 713604000760 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604000761 inhibitor-cofactor binding pocket; inhibition site 713604000762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604000763 catalytic residue [active] 713604000764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604000765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604000766 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604000767 putative dimerization interface [polypeptide binding]; other site 713604000768 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 713604000769 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 713604000770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604000771 binding surface 713604000772 TPR motif; other site 713604000773 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 713604000774 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604000775 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604000776 3D domain; Region: 3D; cl01439 713604000777 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 713604000778 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 713604000779 dimer interface [polypeptide binding]; other site 713604000780 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604000781 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604000782 active site 713604000783 catalytic tetrad [active] 713604000784 MarR family; Region: MarR_2; pfam12802 713604000785 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604000786 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604000787 ATP binding site [chemical binding]; other site 713604000788 Mg2+ binding site [ion binding]; other site 713604000789 G-X-G motif; other site 713604000790 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 713604000791 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000792 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604000793 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604000794 DNA binding residues [nucleotide binding] 713604000795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604000796 Transcription factor WhiB; Region: Whib; pfam02467 713604000797 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604000798 anti sigma factor interaction site; other site 713604000799 regulatory phosphorylation site [posttranslational modification]; other site 713604000800 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 713604000801 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604000802 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604000803 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 713604000804 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604000805 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604000806 Walker A/P-loop; other site 713604000807 ATP binding site [chemical binding]; other site 713604000808 Q-loop/lid; other site 713604000809 ABC transporter signature motif; other site 713604000810 Walker B; other site 713604000811 D-loop; other site 713604000812 H-loop/switch region; other site 713604000813 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 713604000814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604000815 dimerization interface [polypeptide binding]; other site 713604000816 putative Zn2+ binding site [ion binding]; other site 713604000817 putative DNA binding site [nucleotide binding]; other site 713604000818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604000819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604000820 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 713604000821 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604000822 NAD binding site [chemical binding]; other site 713604000823 substrate binding site [chemical binding]; other site 713604000824 putative active site [active] 713604000825 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 713604000826 active site 713604000827 catalytic triad [active] 713604000828 oxyanion hole [active] 713604000829 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604000830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000831 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604000832 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 713604000833 NodB motif; other site 713604000834 active site 713604000835 catalytic site [active] 713604000836 metal binding site [ion binding]; metal-binding site 713604000837 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 713604000838 putative hydrophobic ligand binding site [chemical binding]; other site 713604000839 protein interface [polypeptide binding]; other site 713604000840 gate; other site 713604000841 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 713604000842 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 713604000843 prephenate dehydrogenase; Validated; Region: PRK06545 713604000844 prephenate dehydrogenase; Validated; Region: PRK08507 713604000845 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 713604000846 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 713604000847 active site 713604000848 FMN binding site [chemical binding]; other site 713604000849 2,4-decadienoyl-CoA binding site; other site 713604000850 catalytic residue [active] 713604000851 4Fe-4S cluster binding site [ion binding]; other site 713604000852 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 713604000853 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604000854 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604000855 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 713604000856 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 713604000857 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 713604000858 active site 713604000859 nucleophile elbow; other site 713604000860 Leucine carboxyl methyltransferase; Region: LCM; cl01306 713604000861 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604000862 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604000863 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 713604000864 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604000865 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604000866 substrate binding pocket [chemical binding]; other site 713604000867 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604000868 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 713604000869 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 713604000870 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604000871 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604000872 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604000873 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604000874 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 713604000875 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 713604000876 tetramer interface [polypeptide binding]; other site 713604000877 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 713604000878 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604000879 DinB superfamily; Region: DinB_2; pfam12867 713604000880 AAA domain; Region: AAA_33; pfam13671 713604000881 AAA domain; Region: AAA_17; pfam13207 713604000882 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 713604000883 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604000884 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604000885 active site 713604000886 Cellulose synthase-like protein; Region: PLN02893 713604000887 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604000888 catalytic core [active] 713604000889 Alginate lyase; Region: Alginate_lyase; pfam05426 713604000890 Homeodomain-like domain; Region: HTH_23; pfam13384 713604000891 Winged helix-turn helix; Region: HTH_29; pfam13551 713604000892 Homeodomain-like domain; Region: HTH_32; pfam13565 713604000893 DDE superfamily endonuclease; Region: DDE_3; pfam13358 713604000894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 713604000895 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 713604000896 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604000897 cleavage site 713604000898 active site 713604000899 substrate binding sites [chemical binding]; other site 713604000900 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604000901 active site 713604000902 ATP binding site [chemical binding]; other site 713604000903 substrate binding site [chemical binding]; other site 713604000904 activation loop (A-loop); other site 713604000905 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 713604000906 active site 713604000907 zinc binding site [ion binding]; other site 713604000908 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 713604000909 active site 713604000910 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 713604000911 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 713604000912 active site 713604000913 NAD binding site [chemical binding]; other site 713604000914 metal binding site [ion binding]; metal-binding site 713604000915 thiamine pyrophosphate protein; Validated; Region: PRK08199 713604000916 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604000917 PYR/PP interface [polypeptide binding]; other site 713604000918 dimer interface [polypeptide binding]; other site 713604000919 TPP binding site [chemical binding]; other site 713604000920 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604000921 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 713604000922 TPP-binding site [chemical binding]; other site 713604000923 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604000924 DNA-binding site [nucleotide binding]; DNA binding site 713604000925 RNA-binding motif; other site 713604000926 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604000927 metal-binding site [ion binding] 713604000928 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 713604000929 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 713604000930 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604000931 TPP-binding site [chemical binding]; other site 713604000932 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 713604000933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604000934 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604000935 substrate binding pocket [chemical binding]; other site 713604000936 membrane-bound complex binding site; other site 713604000937 hinge residues; other site 713604000938 Protein kinase domain; Region: Pkinase; pfam00069 713604000939 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604000940 active site 713604000941 ATP binding site [chemical binding]; other site 713604000942 substrate binding site [chemical binding]; other site 713604000943 activation loop (A-loop); other site 713604000944 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 713604000945 active site 2 [active] 713604000946 active site 1 [active] 713604000947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604000948 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604000949 putative substrate translocation pore; other site 713604000950 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604000951 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604000952 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604000953 DNA binding residues [nucleotide binding] 713604000954 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 713604000955 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 713604000956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 713604000957 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604000958 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604000959 DNA-binding site [nucleotide binding]; DNA binding site 713604000960 RNA-binding motif; other site 713604000961 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604000962 Int/Topo IB signature motif; other site 713604000963 DNA binding site [nucleotide binding] 713604000964 Helix-turn-helix domain; Region: HTH_17; cl17695 713604000965 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 713604000966 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 713604000967 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 713604000968 cofactor binding site; other site 713604000969 DNA binding site [nucleotide binding] 713604000970 substrate interaction site [chemical binding]; other site 713604000971 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 713604000972 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 713604000973 polymerase nucleotide-binding site; other site 713604000974 DNA-binding residues [nucleotide binding]; DNA binding site 713604000975 nucleotide binding site [chemical binding]; other site 713604000976 primase nucleotide-binding site [nucleotide binding]; other site 713604000977 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 713604000978 dimer interface [polypeptide binding]; other site 713604000979 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 713604000980 ssDNA binding site [nucleotide binding]; other site 713604000981 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604000982 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 713604000983 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 713604000984 nudix motif; other site 713604000985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604000986 Coenzyme A binding pocket [chemical binding]; other site 713604000987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604000988 YCII-related domain; Region: YCII; cl00999 713604000989 N-acetyltransferase; Region: Acetyltransf_2; cl00949 713604000990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604000991 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 713604000992 putative active site [active] 713604000993 heme pocket [chemical binding]; other site 713604000994 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604000995 putative active site [active] 713604000996 heme pocket [chemical binding]; other site 713604000997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604000998 putative active site [active] 713604000999 heme pocket [chemical binding]; other site 713604001000 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604001001 metal binding site [ion binding]; metal-binding site 713604001002 active site 713604001003 I-site; other site 713604001004 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604001005 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604001006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604001007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604001008 xanthine permease; Region: pbuX; TIGR03173 713604001009 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 713604001010 substrate binding site [chemical binding]; other site 713604001011 THF binding site; other site 713604001012 zinc-binding site [ion binding]; other site 713604001013 NIPSNAP; Region: NIPSNAP; pfam07978 713604001014 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604001015 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604001016 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604001017 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604001018 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604001019 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604001020 Clp amino terminal domain; Region: Clp_N; pfam02861 713604001021 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604001022 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 713604001023 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 713604001024 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604001025 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604001026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604001027 non-specific DNA binding site [nucleotide binding]; other site 713604001028 salt bridge; other site 713604001029 sequence-specific DNA binding site [nucleotide binding]; other site 713604001030 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604001031 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604001032 Methyltransferase domain; Region: Methyltransf_26; pfam13659 713604001033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001034 S-adenosylmethionine binding site [chemical binding]; other site 713604001035 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604001036 YtkA-like; Region: YtkA; pfam13115 713604001037 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604001038 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 713604001039 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604001040 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604001041 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 713604001042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604001043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604001044 amidase; Provisional; Region: PRK06061 713604001045 Amidase; Region: Amidase; cl11426 713604001046 RibD C-terminal domain; Region: RibD_C; cl17279 713604001047 D-cysteine desulfhydrase; Validated; Region: PRK03910 713604001048 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 713604001049 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604001050 catalytic residue [active] 713604001051 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 713604001052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 713604001053 Clp amino terminal domain; Region: Clp_N; pfam02861 713604001054 Clp amino terminal domain; Region: Clp_N; pfam02861 713604001055 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 713604001056 Predicted membrane protein [Function unknown]; Region: COG2364 713604001057 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604001058 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604001059 DNA-binding site [nucleotide binding]; DNA binding site 713604001060 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604001061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001062 homodimer interface [polypeptide binding]; other site 713604001063 catalytic residue [active] 713604001064 aminotransferase; Validated; Region: PRK07777 713604001065 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604001066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001067 homodimer interface [polypeptide binding]; other site 713604001068 catalytic residue [active] 713604001069 Protein of unknown function (DUF445); Region: DUF445; pfam04286 713604001070 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604001071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604001072 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604001073 active site 713604001074 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 713604001075 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 713604001076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604001077 Walker A/P-loop; other site 713604001078 ATP binding site [chemical binding]; other site 713604001079 Q-loop/lid; other site 713604001080 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 713604001081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001082 S-adenosylmethionine binding site [chemical binding]; other site 713604001083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604001084 non-specific DNA binding site [nucleotide binding]; other site 713604001085 salt bridge; other site 713604001086 sequence-specific DNA binding site [nucleotide binding]; other site 713604001087 CT11-RanBPM; Region: CRA; smart00757 713604001088 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 713604001089 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 713604001090 putative deacylase active site [active] 713604001091 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 713604001092 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 713604001093 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 713604001094 active sites [active] 713604001095 tetramer interface [polypeptide binding]; other site 713604001096 Cadmium resistance transporter; Region: Cad; pfam03596 713604001097 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 713604001098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604001099 dimer interface [polypeptide binding]; other site 713604001100 conserved gate region; other site 713604001101 putative PBP binding loops; other site 713604001102 ABC-ATPase subunit interface; other site 713604001103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604001104 dimer interface [polypeptide binding]; other site 713604001105 conserved gate region; other site 713604001106 putative PBP binding loops; other site 713604001107 ABC-ATPase subunit interface; other site 713604001108 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 713604001109 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 713604001110 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604001111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001112 S-adenosylmethionine binding site [chemical binding]; other site 713604001113 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604001114 MarR family; Region: MarR; pfam01047 713604001115 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604001116 hydrophobic ligand binding site; other site 713604001117 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 713604001118 Prostaglandin dehydrogenases; Region: PGDH; cd05288 713604001119 NAD(P) binding site [chemical binding]; other site 713604001120 substrate binding site [chemical binding]; other site 713604001121 dimer interface [polypeptide binding]; other site 713604001122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604001123 motif II; other site 713604001124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604001125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604001126 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 713604001127 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 713604001128 putative NAD(P) binding site [chemical binding]; other site 713604001129 putative substrate binding site [chemical binding]; other site 713604001130 catalytic Zn binding site [ion binding]; other site 713604001131 structural Zn binding site [ion binding]; other site 713604001132 dimer interface [polypeptide binding]; other site 713604001133 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 713604001134 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 713604001135 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 713604001136 putative active site [active] 713604001137 putative substrate binding site [chemical binding]; other site 713604001138 putative cosubstrate binding site; other site 713604001139 catalytic site [active] 713604001140 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604001141 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604001142 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604001143 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 713604001144 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 713604001145 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 713604001146 FAD binding domain; Region: FAD_binding_4; pfam01565 713604001147 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 713604001148 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 713604001149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 713604001150 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 713604001151 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604001152 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604001153 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604001154 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 713604001155 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 713604001156 putative ADP-binding pocket [chemical binding]; other site 713604001157 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 713604001158 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 713604001159 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604001160 catalytic core [active] 713604001161 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 713604001162 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604001163 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 713604001164 dimerization interface [polypeptide binding]; other site 713604001165 DNA binding residues [nucleotide binding] 713604001166 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604001167 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604001168 active site 713604001169 catalytic tetrad [active] 713604001170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604001171 dimer interface [polypeptide binding]; other site 713604001172 phosphorylation site [posttranslational modification] 713604001173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604001174 ATP binding site [chemical binding]; other site 713604001175 Mg2+ binding site [ion binding]; other site 713604001176 G-X-G motif; other site 713604001177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604001178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604001179 active site 713604001180 phosphorylation site [posttranslational modification] 713604001181 intermolecular recognition site; other site 713604001182 dimerization interface [polypeptide binding]; other site 713604001183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604001184 DNA binding site [nucleotide binding] 713604001185 exopolyphosphatase; Region: exo_poly_only; TIGR03706 713604001186 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 713604001187 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 713604001188 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604001189 DNA interaction; other site 713604001190 Metal-binding active site; metal-binding site 713604001191 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 713604001192 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604001193 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 713604001194 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 713604001195 DNA binding domain, excisionase family; Region: excise; TIGR01764 713604001196 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 713604001197 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604001198 putative NAD(P) binding site [chemical binding]; other site 713604001199 active site 713604001200 putative substrate binding site [chemical binding]; other site 713604001201 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604001202 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 713604001203 putative acyl-acceptor binding pocket; other site 713604001204 Putative sensor; Region: Sensor; pfam13796 713604001205 Histidine kinase; Region: HisKA_3; pfam07730 713604001206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604001207 ATP binding site [chemical binding]; other site 713604001208 Mg2+ binding site [ion binding]; other site 713604001209 G-X-G motif; other site 713604001210 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604001211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604001212 active site 713604001213 phosphorylation site [posttranslational modification] 713604001214 intermolecular recognition site; other site 713604001215 dimerization interface [polypeptide binding]; other site 713604001216 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 713604001217 DNA binding residues [nucleotide binding] 713604001218 CAAX protease self-immunity; Region: Abi; pfam02517 713604001219 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 713604001220 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 713604001221 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 713604001222 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604001223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604001224 DNA binding residues [nucleotide binding] 713604001225 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604001226 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604001227 acyl-activating enzyme (AAE) consensus motif; other site 713604001228 AMP binding site [chemical binding]; other site 713604001229 active site 713604001230 CoA binding site [chemical binding]; other site 713604001231 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 713604001232 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 713604001233 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 713604001234 Moco binding site; other site 713604001235 metal coordination site [ion binding]; other site 713604001236 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 713604001237 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 713604001238 CoA binding domain; Region: CoA_binding; smart00881 713604001239 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 713604001240 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 713604001241 tRNA; other site 713604001242 putative tRNA binding site [nucleotide binding]; other site 713604001243 putative NADP binding site [chemical binding]; other site 713604001244 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 713604001245 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 713604001246 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 713604001247 domain interfaces; other site 713604001248 active site 713604001249 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 713604001250 active site 713604001251 homodimer interface [polypeptide binding]; other site 713604001252 SAM binding site [chemical binding]; other site 713604001253 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 713604001254 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 713604001255 active site 713604001256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604001257 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604001258 NAD(P) binding site [chemical binding]; other site 713604001259 active site 713604001260 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604001261 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 713604001262 dimer interface [polypeptide binding]; other site 713604001263 active site 713604001264 Schiff base residues; other site 713604001265 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 713604001266 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 713604001267 HlyD family secretion protein; Region: HlyD_3; pfam13437 713604001268 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 713604001269 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604001270 Walker A/P-loop; other site 713604001271 ATP binding site [chemical binding]; other site 713604001272 Q-loop/lid; other site 713604001273 ABC transporter signature motif; other site 713604001274 Walker B; other site 713604001275 D-loop; other site 713604001276 H-loop/switch region; other site 713604001277 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 713604001278 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 713604001279 FtsX-like permease family; Region: FtsX; pfam02687 713604001280 TspO/MBR family; Region: TspO_MBR; pfam03073 713604001281 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 713604001282 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604001283 inhibitor-cofactor binding pocket; inhibition site 713604001284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001285 catalytic residue [active] 713604001286 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604001287 catalytic core [active] 713604001288 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 713604001289 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 713604001290 catalytic residues [active] 713604001291 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 713604001292 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 713604001293 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 713604001294 ResB-like family; Region: ResB; pfam05140 713604001295 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 713604001296 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 713604001297 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 713604001298 DNA binding residues [nucleotide binding] 713604001299 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604001300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604001301 putative DNA binding site [nucleotide binding]; other site 713604001302 putative Zn2+ binding site [ion binding]; other site 713604001303 AsnC family; Region: AsnC_trans_reg; pfam01037 713604001304 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 713604001305 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 713604001306 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604001307 catalytic residue [active] 713604001308 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 713604001309 UbiA prenyltransferase family; Region: UbiA; pfam01040 713604001310 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 713604001311 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604001312 acyl-activating enzyme (AAE) consensus motif; other site 713604001313 AMP binding site [chemical binding]; other site 713604001314 active site 713604001315 CoA binding site [chemical binding]; other site 713604001316 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604001317 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 713604001318 substrate binding site [chemical binding]; other site 713604001319 oxyanion hole (OAH) forming residues; other site 713604001320 trimer interface [polypeptide binding]; other site 713604001321 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 713604001322 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 713604001323 dimer interface [polypeptide binding]; other site 713604001324 tetramer interface [polypeptide binding]; other site 713604001325 PYR/PP interface [polypeptide binding]; other site 713604001326 TPP binding site [chemical binding]; other site 713604001327 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 713604001328 TPP-binding site; other site 713604001329 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 713604001330 Zn binding site [ion binding]; other site 713604001331 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 713604001332 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 713604001333 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 713604001334 active site 713604001335 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604001336 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 713604001337 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 713604001338 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 713604001339 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604001340 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 713604001341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001342 S-adenosylmethionine binding site [chemical binding]; other site 713604001343 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 713604001344 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 713604001345 NADH dehydrogenase subunit B; Validated; Region: PRK06411 713604001346 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 713604001347 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 713604001348 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 713604001349 NADH dehydrogenase subunit D; Validated; Region: PRK06075 713604001350 NADH dehydrogenase subunit E; Validated; Region: PRK07539 713604001351 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 713604001352 putative dimer interface [polypeptide binding]; other site 713604001353 [2Fe-2S] cluster binding site [ion binding]; other site 713604001354 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 713604001355 SLBB domain; Region: SLBB; pfam10531 713604001356 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 713604001357 NADH dehydrogenase subunit G; Validated; Region: PRK07860 713604001358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604001359 catalytic loop [active] 713604001360 iron binding site [ion binding]; other site 713604001361 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 713604001362 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604001363 molybdopterin cofactor binding site; other site 713604001364 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 713604001365 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 713604001366 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 713604001367 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 713604001368 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 713604001369 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 713604001370 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 713604001371 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 713604001372 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 713604001373 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 713604001374 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 713604001375 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 713604001376 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 713604001377 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 713604001378 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 713604001379 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 713604001380 EspG family; Region: ESX-1_EspG; pfam14011 713604001381 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 713604001382 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 713604001383 substrate binding pocket [chemical binding]; other site 713604001384 chain length determination region; other site 713604001385 substrate-Mg2+ binding site; other site 713604001386 catalytic residues [active] 713604001387 aspartate-rich region 1; other site 713604001388 active site lid residues [active] 713604001389 aspartate-rich region 2; other site 713604001390 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604001391 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604001392 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 713604001393 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 713604001394 TPP-binding site [chemical binding]; other site 713604001395 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 713604001396 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 713604001397 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 713604001398 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 713604001399 dimer interface [polypeptide binding]; other site 713604001400 PYR/PP interface [polypeptide binding]; other site 713604001401 TPP binding site [chemical binding]; other site 713604001402 substrate binding site [chemical binding]; other site 713604001403 enoyl-CoA hydratase; Provisional; Region: PRK05870 713604001404 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604001405 substrate binding site [chemical binding]; other site 713604001406 oxyanion hole (OAH) forming residues; other site 713604001407 trimer interface [polypeptide binding]; other site 713604001408 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604001409 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604001410 AsnC family; Region: AsnC_trans_reg; pfam01037 713604001411 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 713604001412 Amidinotransferase; Region: Amidinotransf; pfam02274 713604001413 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 713604001414 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604001415 putative active site [active] 713604001416 putative metal binding site [ion binding]; other site 713604001417 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 713604001418 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 713604001419 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 713604001420 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 713604001421 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 713604001422 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 713604001423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604001424 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 713604001425 Chain length determinant protein; Region: Wzz; cl15801 713604001426 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 713604001427 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 713604001428 active site 713604001429 dimer interface [polypeptide binding]; other site 713604001430 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 713604001431 Ligand Binding Site [chemical binding]; other site 713604001432 Molecular Tunnel; other site 713604001433 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604001434 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 713604001435 putative NAD(P) binding site [chemical binding]; other site 713604001436 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604001437 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604001438 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 713604001439 Right handed beta helix region; Region: Beta_helix; pfam13229 713604001440 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604001441 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604001442 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 713604001443 active site 713604001444 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604001445 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604001446 Right handed beta helix region; Region: Beta_helix; pfam13229 713604001447 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 713604001448 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604001449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604001450 catalytic residue [active] 713604001451 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 713604001452 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 713604001453 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 713604001454 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 713604001455 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 713604001456 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 713604001457 active site 713604001458 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 713604001459 M28 Zn-Peptidases; Region: M28_like_3; cd05644 713604001460 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 713604001461 active site 713604001462 metal binding site [ion binding]; metal-binding site 713604001463 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 713604001464 extended (e) SDRs; Region: SDR_e; cd08946 713604001465 NAD(P) binding site [chemical binding]; other site 713604001466 active site 713604001467 substrate binding site [chemical binding]; other site 713604001468 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 713604001469 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 713604001470 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604001471 active site 713604001472 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 713604001473 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604001474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604001475 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 713604001476 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604001477 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604001478 Uncharacterized conserved protein [Function unknown]; Region: COG3391 713604001479 heat shock protein HtpX; Provisional; Region: PRK03072 713604001480 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604001481 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 713604001482 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 713604001483 active site 713604001484 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 713604001485 non-prolyl cis peptide bond; other site 713604001486 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 713604001487 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 713604001488 substrate binding site; other site 713604001489 tetramer interface; other site 713604001490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 713604001491 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 713604001492 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604001493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001494 S-adenosylmethionine binding site [chemical binding]; other site 713604001495 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 713604001496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604001497 Walker A motif; other site 713604001498 ATP binding site [chemical binding]; other site 713604001499 Walker B motif; other site 713604001500 arginine finger; other site 713604001501 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 713604001502 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604001503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001504 S-adenosylmethionine binding site [chemical binding]; other site 713604001505 putative acetyltransferase; Provisional; Region: PRK03624 713604001506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604001507 Coenzyme A binding pocket [chemical binding]; other site 713604001508 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604001509 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604001510 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604001511 metal binding site [ion binding]; metal-binding site 713604001512 active site 713604001513 I-site; other site 713604001514 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604001515 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 713604001516 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 713604001517 active site 713604001518 catalytic site [active] 713604001519 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 713604001520 active site 713604001521 catalytic site [active] 713604001522 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 713604001523 active site 713604001524 catalytic triad [active] 713604001525 oxyanion hole [active] 713604001526 Predicted transcriptional regulators [Transcription]; Region: COG1725 713604001527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604001528 DNA-binding site [nucleotide binding]; DNA binding site 713604001529 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604001530 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604001531 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 713604001532 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 713604001533 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 713604001534 putative homodimer interface [polypeptide binding]; other site 713604001535 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 713604001536 heterodimer interface [polypeptide binding]; other site 713604001537 homodimer interface [polypeptide binding]; other site 713604001538 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 713604001539 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 713604001540 23S rRNA interface [nucleotide binding]; other site 713604001541 putative thiostrepton binding site; other site 713604001542 L7/L12 interface [polypeptide binding]; other site 713604001543 L25 interface [polypeptide binding]; other site 713604001544 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 713604001545 mRNA/rRNA interface [nucleotide binding]; other site 713604001546 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604001547 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604001548 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 713604001549 23S rRNA interface [nucleotide binding]; other site 713604001550 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 713604001551 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 713604001552 L11 interface [polypeptide binding]; other site 713604001553 putative EF-Tu interaction site [polypeptide binding]; other site 713604001554 putative EF-G interaction site [polypeptide binding]; other site 713604001555 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 713604001556 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 713604001557 Walker A/P-loop; other site 713604001558 ATP binding site [chemical binding]; other site 713604001559 Q-loop/lid; other site 713604001560 ABC transporter signature motif; other site 713604001561 Walker B; other site 713604001562 D-loop; other site 713604001563 H-loop/switch region; other site 713604001564 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604001565 Permease; Region: Permease; pfam02405 713604001566 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604001567 Permease; Region: Permease; pfam02405 713604001568 mce related protein; Region: MCE; pfam02470 713604001569 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604001570 mce related protein; Region: MCE; pfam02470 713604001571 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604001572 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604001573 mce related protein; Region: MCE; pfam02470 713604001574 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604001575 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 713604001576 linker region; other site 713604001577 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604001578 mce related protein; Region: MCE; pfam02470 713604001579 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604001580 mce related protein; Region: MCE; pfam02470 713604001581 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604001582 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604001583 mce related protein; Region: MCE; pfam02470 713604001584 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604001585 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604001586 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604001587 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604001588 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604001589 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001590 Cytochrome P450; Region: p450; cl12078 713604001591 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604001592 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604001593 acyl-activating enzyme (AAE) consensus motif; other site 713604001594 AMP binding site [chemical binding]; other site 713604001595 active site 713604001596 CoA binding site [chemical binding]; other site 713604001597 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001598 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001599 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001600 active site 713604001601 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001602 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001603 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001604 putative NADP binding site [chemical binding]; other site 713604001605 KR domain; Region: KR; pfam08659 713604001606 active site 713604001607 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001608 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001609 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001610 active site 713604001611 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001612 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001613 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001614 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 713604001615 active site 713604001616 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604001617 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001618 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 713604001619 KR domain; Region: KR; pfam08659 713604001620 NADP binding site [chemical binding]; other site 713604001621 active site 713604001622 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001623 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001624 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001625 active site 713604001626 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001627 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001628 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001629 putative NADP binding site [chemical binding]; other site 713604001630 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001631 active site 713604001632 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001633 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001634 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001635 active site 713604001636 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001637 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001638 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001639 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001640 putative NADP binding site [chemical binding]; other site 713604001641 active site 713604001642 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001643 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001644 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001645 active site 713604001646 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001647 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001648 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001649 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001650 putative NADP binding site [chemical binding]; other site 713604001651 active site 713604001652 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001653 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001654 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001655 active site 713604001656 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001657 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001658 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001659 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001660 putative NADP binding site [chemical binding]; other site 713604001661 active site 713604001662 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001663 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001664 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001665 active site 713604001666 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001667 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001668 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001669 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001670 putative NADP binding site [chemical binding]; other site 713604001671 active site 713604001672 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001673 Erythronolide synthase docking; Region: Docking; pfam08990 713604001674 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001675 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001676 active site 713604001677 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001678 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001679 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001680 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001681 putative NADP binding site [chemical binding]; other site 713604001682 active site 713604001683 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001684 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604001685 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604001686 active site 713604001687 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604001688 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604001689 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604001690 putative NADP binding site [chemical binding]; other site 713604001691 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604001692 active site 713604001693 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604001694 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 713604001695 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 713604001696 dimer interface [polypeptide binding]; other site 713604001697 active site 713604001698 metal binding site [ion binding]; metal-binding site 713604001699 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 713604001700 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 713604001701 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 713604001702 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 713604001703 shikimate binding site; other site 713604001704 NAD(P) binding site [chemical binding]; other site 713604001705 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 713604001706 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 713604001707 inhibitor-cofactor binding pocket; inhibition site 713604001708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001709 catalytic residue [active] 713604001710 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604001711 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604001712 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604001713 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 713604001714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604001715 motif II; other site 713604001716 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604001717 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 713604001718 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604001719 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604001720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604001721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604001722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604001723 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604001724 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604001725 Cytochrome P450; Region: p450; cl12078 713604001726 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001727 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001728 Cytochrome P450; Region: p450; cl12078 713604001729 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 713604001730 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 713604001731 inhibitor-cofactor binding pocket; inhibition site 713604001732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001733 catalytic residue [active] 713604001734 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604001735 homodimer interface [polypeptide binding]; other site 713604001736 active site 713604001737 TDP-binding site; other site 713604001738 acceptor substrate-binding pocket; other site 713604001739 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 713604001740 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604001741 acetylornithine transaminase; Region: PLN00144 713604001742 inhibitor-cofactor binding pocket; inhibition site 713604001743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604001744 catalytic residue [active] 713604001745 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604001746 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604001747 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604001748 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604001749 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604001750 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604001751 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604001752 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604001753 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 713604001754 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 713604001755 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 713604001756 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604001757 acyltransferase PapA5; Provisional; Region: PRK09294 713604001758 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604001759 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604001760 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001761 Cytochrome P450; Region: p450; cl12078 713604001762 tocopherol O-methyltransferase; Region: PLN02244 713604001763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604001764 S-adenosylmethionine binding site [chemical binding]; other site 713604001765 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604001766 TPP-binding site [chemical binding]; other site 713604001767 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 713604001768 PYR/PP interface [polypeptide binding]; other site 713604001769 dimer interface [polypeptide binding]; other site 713604001770 TPP binding site [chemical binding]; other site 713604001771 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001772 Cytochrome P450; Region: p450; cl12078 713604001773 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 713604001774 Dehydroquinase class II; Region: DHquinase_II; pfam01220 713604001775 active site 713604001776 trimer interface [polypeptide binding]; other site 713604001777 dimer interface [polypeptide binding]; other site 713604001778 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604001779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604001780 DNA binding residues [nucleotide binding] 713604001781 dimerization interface [polypeptide binding]; other site 713604001782 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 713604001783 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 713604001784 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 713604001785 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 713604001786 RPB1 interaction site [polypeptide binding]; other site 713604001787 RPB10 interaction site [polypeptide binding]; other site 713604001788 RPB11 interaction site [polypeptide binding]; other site 713604001789 RPB3 interaction site [polypeptide binding]; other site 713604001790 RPB12 interaction site [polypeptide binding]; other site 713604001791 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 713604001792 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 713604001793 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 713604001794 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 713604001795 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 713604001796 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 713604001797 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 713604001798 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 713604001799 DNA binding site [nucleotide binding] 713604001800 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 713604001801 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 713604001802 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604001803 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604001804 putative DNA binding site [nucleotide binding]; other site 713604001805 putative Zn2+ binding site [ion binding]; other site 713604001806 AsnC family; Region: AsnC_trans_reg; pfam01037 713604001807 Double zinc ribbon; Region: DZR; pfam12773 713604001808 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604001809 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604001810 ligand binding site [chemical binding]; other site 713604001811 flexible hinge region; other site 713604001812 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 713604001813 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 713604001814 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 713604001815 S17 interaction site [polypeptide binding]; other site 713604001816 S8 interaction site; other site 713604001817 16S rRNA interaction site [nucleotide binding]; other site 713604001818 streptomycin interaction site [chemical binding]; other site 713604001819 23S rRNA interaction site [nucleotide binding]; other site 713604001820 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 713604001821 30S ribosomal protein S7; Validated; Region: PRK05302 713604001822 elongation factor G; Reviewed; Region: PRK00007 713604001823 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 713604001824 G1 box; other site 713604001825 putative GEF interaction site [polypeptide binding]; other site 713604001826 GTP/Mg2+ binding site [chemical binding]; other site 713604001827 Switch I region; other site 713604001828 G2 box; other site 713604001829 G3 box; other site 713604001830 Switch II region; other site 713604001831 G4 box; other site 713604001832 G5 box; other site 713604001833 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 713604001834 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 713604001835 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 713604001836 elongation factor Tu; Reviewed; Region: PRK00049 713604001837 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 713604001838 G1 box; other site 713604001839 GEF interaction site [polypeptide binding]; other site 713604001840 GTP/Mg2+ binding site [chemical binding]; other site 713604001841 Switch I region; other site 713604001842 G2 box; other site 713604001843 G3 box; other site 713604001844 Switch II region; other site 713604001845 G4 box; other site 713604001846 G5 box; other site 713604001847 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 713604001848 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 713604001849 Antibiotic Binding Site [chemical binding]; other site 713604001850 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 713604001851 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 713604001852 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 713604001853 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 713604001854 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 713604001855 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 713604001856 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 713604001857 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 713604001858 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 713604001859 putative translocon binding site; other site 713604001860 protein-rRNA interface [nucleotide binding]; other site 713604001861 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 713604001862 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 713604001863 G-X-X-G motif; other site 713604001864 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 713604001865 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 713604001866 23S rRNA interface [nucleotide binding]; other site 713604001867 5S rRNA interface [nucleotide binding]; other site 713604001868 putative antibiotic binding site [chemical binding]; other site 713604001869 L25 interface [polypeptide binding]; other site 713604001870 L27 interface [polypeptide binding]; other site 713604001871 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 713604001872 23S rRNA interface [nucleotide binding]; other site 713604001873 putative translocon interaction site; other site 713604001874 signal recognition particle (SRP54) interaction site; other site 713604001875 L23 interface [polypeptide binding]; other site 713604001876 trigger factor interaction site; other site 713604001877 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 713604001878 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 713604001879 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 713604001880 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 713604001881 RNA binding site [nucleotide binding]; other site 713604001882 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 713604001883 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 713604001884 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 713604001885 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 713604001886 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 713604001887 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 713604001888 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 713604001889 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 713604001890 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 713604001891 5S rRNA interface [nucleotide binding]; other site 713604001892 L27 interface [polypeptide binding]; other site 713604001893 23S rRNA interface [nucleotide binding]; other site 713604001894 L5 interface [polypeptide binding]; other site 713604001895 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 713604001896 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 713604001897 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 713604001898 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 713604001899 23S rRNA binding site [nucleotide binding]; other site 713604001900 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 713604001901 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604001902 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 713604001903 SecY translocase; Region: SecY; pfam00344 713604001904 adenylate kinase; Reviewed; Region: adk; PRK00279 713604001905 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 713604001906 AMP-binding site [chemical binding]; other site 713604001907 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 713604001908 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 713604001909 active site 713604001910 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 713604001911 rRNA binding site [nucleotide binding]; other site 713604001912 predicted 30S ribosome binding site; other site 713604001913 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 713604001914 30S ribosomal protein S13; Region: bact_S13; TIGR03631 713604001915 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 713604001916 30S ribosomal protein S11; Validated; Region: PRK05309 713604001917 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 713604001918 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 713604001919 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713604001920 RNA binding surface [nucleotide binding]; other site 713604001921 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 713604001922 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 713604001923 alphaNTD homodimer interface [polypeptide binding]; other site 713604001924 alphaNTD - beta interaction site [polypeptide binding]; other site 713604001925 alphaNTD - beta' interaction site [polypeptide binding]; other site 713604001926 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 713604001927 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 713604001928 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 713604001929 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 713604001930 active site 713604001931 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 713604001932 Protein of unknown function (DUF690); Region: DUF690; cl04939 713604001933 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 713604001934 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604001935 catalytic residues [active] 713604001936 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604001937 active site 713604001938 catalytic residues [active] 713604001939 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 713604001940 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 713604001941 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 713604001942 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604001943 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 713604001944 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604001945 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 713604001946 nucleotide binding site [chemical binding]; other site 713604001947 putative NEF/HSP70 interaction site [polypeptide binding]; other site 713604001948 SBD interface [polypeptide binding]; other site 713604001949 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 713604001950 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 713604001951 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 713604001952 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 713604001953 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 713604001954 23S rRNA interface [nucleotide binding]; other site 713604001955 L3 interface [polypeptide binding]; other site 713604001956 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 713604001957 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 713604001958 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 713604001959 active site 713604001960 substrate binding site [chemical binding]; other site 713604001961 metal binding site [ion binding]; metal-binding site 713604001962 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604001963 acyl-CoA synthetase; Validated; Region: PRK05850 713604001964 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604001965 acyl-activating enzyme (AAE) consensus motif; other site 713604001966 active site 713604001967 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604001968 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604001969 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 713604001970 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 713604001971 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 713604001972 glutaminase active site [active] 713604001973 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 713604001974 dimer interface [polypeptide binding]; other site 713604001975 active site 713604001976 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 713604001977 dimer interface [polypeptide binding]; other site 713604001978 active site 713604001979 Uncharacterized conserved protein [Function unknown]; Region: COG0062 713604001980 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 713604001981 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604001982 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604001983 glycerol kinase; Region: PLN02295 713604001984 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604001985 nucleotide binding site [chemical binding]; other site 713604001986 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 713604001987 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 713604001988 Walker A/P-loop; other site 713604001989 ATP binding site [chemical binding]; other site 713604001990 Q-loop/lid; other site 713604001991 ABC transporter signature motif; other site 713604001992 Walker B; other site 713604001993 D-loop; other site 713604001994 H-loop/switch region; other site 713604001995 TOBE domain; Region: TOBE_2; pfam08402 713604001996 alanine racemase; Reviewed; Region: alr; PRK00053 713604001997 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 713604001998 active site 713604001999 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604002000 dimer interface [polypeptide binding]; other site 713604002001 substrate binding site [chemical binding]; other site 713604002002 catalytic residues [active] 713604002003 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604002004 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604002005 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 713604002006 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 713604002007 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 713604002008 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 713604002009 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604002010 acyl-CoA synthetase; Validated; Region: PRK07787 713604002011 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604002012 acyl-activating enzyme (AAE) consensus motif; other site 713604002013 AMP binding site [chemical binding]; other site 713604002014 active site 713604002015 CoA binding site [chemical binding]; other site 713604002016 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 713604002017 Glycoprotease family; Region: Peptidase_M22; pfam00814 713604002018 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 713604002019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604002020 Coenzyme A binding pocket [chemical binding]; other site 713604002021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604002022 UGMP family protein; Validated; Region: PRK09604 713604002023 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 713604002024 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 713604002025 active site 713604002026 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 713604002027 homodimer interface [polypeptide binding]; other site 713604002028 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 713604002029 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604002030 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604002031 active site 713604002032 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 713604002033 amidase catalytic site [active] 713604002034 Zn binding residues [ion binding]; other site 713604002035 substrate binding site [chemical binding]; other site 713604002036 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604002037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604002038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604002039 dimerization interface [polypeptide binding]; other site 713604002040 putative DNA binding site [nucleotide binding]; other site 713604002041 putative Zn2+ binding site [ion binding]; other site 713604002042 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 713604002043 Low molecular weight phosphatase family; Region: LMWPc; cd00115 713604002044 active site 713604002045 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 713604002046 arsenical-resistance protein; Region: acr3; TIGR00832 713604002047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604002048 dimerization interface [polypeptide binding]; other site 713604002049 putative DNA binding site [nucleotide binding]; other site 713604002050 putative Zn2+ binding site [ion binding]; other site 713604002051 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604002052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604002053 active site 713604002054 metal binding site [ion binding]; metal-binding site 713604002055 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 713604002056 oligomerisation interface [polypeptide binding]; other site 713604002057 mobile loop; other site 713604002058 roof hairpin; other site 713604002059 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 713604002060 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 713604002061 ring oligomerisation interface [polypeptide binding]; other site 713604002062 ATP/Mg binding site [chemical binding]; other site 713604002063 stacking interactions; other site 713604002064 hinge regions; other site 713604002065 Transcription factor WhiB; Region: Whib; pfam02467 713604002066 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 713604002067 DNA binding residues [nucleotide binding] 713604002068 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604002069 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002071 active site 713604002072 phosphorylation site [posttranslational modification] 713604002073 intermolecular recognition site; other site 713604002074 dimerization interface [polypeptide binding]; other site 713604002075 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002076 DNA binding residues [nucleotide binding] 713604002077 dimerization interface [polypeptide binding]; other site 713604002078 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 713604002079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604002080 DNA binding residues [nucleotide binding] 713604002081 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 713604002082 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604002083 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 713604002084 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 713604002085 active site 713604002086 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 713604002087 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604002088 phosphate binding site [ion binding]; other site 713604002089 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604002090 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 713604002091 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604002092 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 713604002093 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604002094 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604002095 FAD binding domain; Region: FAD_binding_4; pfam01565 713604002096 Berberine and berberine like; Region: BBE; pfam08031 713604002097 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604002098 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 713604002099 NAD(P) binding site [chemical binding]; other site 713604002100 catalytic residues [active] 713604002101 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 713604002102 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604002103 catalytic Zn binding site [ion binding]; other site 713604002104 NAD(P) binding site [chemical binding]; other site 713604002105 structural Zn binding site [ion binding]; other site 713604002106 Rhomboid family; Region: Rhomboid; cl11446 713604002107 DinB superfamily; Region: DinB_2; pfam12867 713604002108 GMP synthase; Reviewed; Region: guaA; PRK00074 713604002109 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 713604002110 AMP/PPi binding site [chemical binding]; other site 713604002111 candidate oxyanion hole; other site 713604002112 catalytic triad [active] 713604002113 potential glutamine specificity residues [chemical binding]; other site 713604002114 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 713604002115 ATP Binding subdomain [chemical binding]; other site 713604002116 Ligand Binding sites [chemical binding]; other site 713604002117 Dimerization subdomain; other site 713604002118 PspC domain; Region: PspC; pfam04024 713604002119 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 713604002120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604002121 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 713604002122 PspC domain; Region: PspC; pfam04024 713604002123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604002124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604002125 ATP binding site [chemical binding]; other site 713604002126 Mg2+ binding site [ion binding]; other site 713604002127 G-X-G motif; other site 713604002128 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002130 active site 713604002131 phosphorylation site [posttranslational modification] 713604002132 intermolecular recognition site; other site 713604002133 dimerization interface [polypeptide binding]; other site 713604002134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002135 DNA binding residues [nucleotide binding] 713604002136 dimerization interface [polypeptide binding]; other site 713604002137 EamA-like transporter family; Region: EamA; pfam00892 713604002138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604002139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604002140 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604002141 putative dimerization interface [polypeptide binding]; other site 713604002142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604002143 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604002144 active site 713604002145 ATP binding site [chemical binding]; other site 713604002146 substrate binding site [chemical binding]; other site 713604002147 activation loop (A-loop); other site 713604002148 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604002149 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604002150 active site 713604002151 ATP binding site [chemical binding]; other site 713604002152 substrate binding site [chemical binding]; other site 713604002153 activation loop (A-loop); other site 713604002154 Chorismate mutase type II; Region: CM_2; cl00693 713604002155 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604002156 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 713604002157 Part of AAA domain; Region: AAA_19; pfam13245 713604002158 Family description; Region: UvrD_C_2; pfam13538 713604002159 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 713604002160 Peptidase family M23; Region: Peptidase_M23; pfam01551 713604002161 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 713604002162 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 713604002163 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 713604002164 CoA-ligase; Region: Ligase_CoA; pfam00549 713604002165 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 713604002166 CoA binding domain; Region: CoA_binding; smart00881 713604002167 CoA-ligase; Region: Ligase_CoA; pfam00549 713604002168 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 713604002169 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 713604002170 active site 713604002171 substrate binding site [chemical binding]; other site 713604002172 cosubstrate binding site; other site 713604002173 catalytic site [active] 713604002174 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 713604002175 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 713604002176 purine monophosphate binding site [chemical binding]; other site 713604002177 dimer interface [polypeptide binding]; other site 713604002178 putative catalytic residues [active] 713604002179 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 713604002180 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 713604002181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604002182 Coenzyme A binding pocket [chemical binding]; other site 713604002183 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 713604002184 Zn2+ binding site [ion binding]; other site 713604002185 Mg2+ binding site [ion binding]; other site 713604002186 Y-family of DNA polymerases; Region: PolY; cl12025 713604002187 DNA binding site [nucleotide binding] 713604002188 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 713604002189 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 713604002190 active site 713604002191 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 713604002192 generic binding surface II; other site 713604002193 generic binding surface I; other site 713604002194 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 713604002195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604002196 S-adenosylmethionine binding site [chemical binding]; other site 713604002197 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 713604002198 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 713604002199 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 713604002200 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 713604002201 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 713604002202 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 713604002203 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 713604002204 homodimer interface [polypeptide binding]; other site 713604002205 NADP binding site [chemical binding]; other site 713604002206 substrate binding site [chemical binding]; other site 713604002207 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 713604002208 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604002209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002210 putative substrate translocation pore; other site 713604002211 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604002212 dimerization interface [polypeptide binding]; other site 713604002213 putative DNA binding site [nucleotide binding]; other site 713604002214 putative Zn2+ binding site [ion binding]; other site 713604002215 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604002216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002217 putative substrate translocation pore; other site 713604002218 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 713604002219 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 713604002220 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 713604002221 minor groove reading motif; other site 713604002222 helix-hairpin-helix signature motif; other site 713604002223 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 713604002224 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604002225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604002226 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 713604002227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604002228 S-adenosylmethionine binding site [chemical binding]; other site 713604002229 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 713604002230 isocitrate dehydrogenase; Validated; Region: PRK08299 713604002231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002233 WHG domain; Region: WHG; pfam13305 713604002234 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 713604002235 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 713604002236 putative active site [active] 713604002237 putative catalytic site [active] 713604002238 putative DNA binding site [nucleotide binding]; other site 713604002239 putative phosphate binding site [ion binding]; other site 713604002240 metal binding site A [ion binding]; metal-binding site 713604002241 putative AP binding site [nucleotide binding]; other site 713604002242 putative metal binding site B [ion binding]; other site 713604002243 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 713604002244 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 713604002245 active site 713604002246 HIGH motif; other site 713604002247 dimer interface [polypeptide binding]; other site 713604002248 KMSKS motif; other site 713604002249 AAA domain; Region: AAA_33; pfam13671 713604002250 AAA domain; Region: AAA_17; pfam13207 713604002251 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 713604002252 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604002253 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604002254 active site 713604002255 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604002256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604002257 dimerization interface [polypeptide binding]; other site 713604002258 putative DNA binding site [nucleotide binding]; other site 713604002259 putative Zn2+ binding site [ion binding]; other site 713604002260 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 713604002261 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 713604002262 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604002263 active site 713604002264 catalytic residues [active] 713604002265 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 713604002266 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 713604002267 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 713604002268 L-aspartate oxidase; Provisional; Region: PRK06175 713604002269 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 713604002270 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 713604002271 putative Iron-sulfur protein interface [polypeptide binding]; other site 713604002272 putative proximal heme binding site [chemical binding]; other site 713604002273 putative SdhC-like subunit interface [polypeptide binding]; other site 713604002274 putative distal heme binding site [chemical binding]; other site 713604002275 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 713604002276 putative Iron-sulfur protein interface [polypeptide binding]; other site 713604002277 putative proximal heme binding site [chemical binding]; other site 713604002278 putative SdhD-like interface [polypeptide binding]; other site 713604002279 putative distal heme binding site [chemical binding]; other site 713604002280 alpha-galactosidase; Region: PLN02808; cl17638 713604002281 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 713604002282 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 713604002283 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 713604002284 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 713604002285 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 713604002286 ligand binding site [chemical binding]; other site 713604002287 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 713604002288 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604002289 Walker A/P-loop; other site 713604002290 ATP binding site [chemical binding]; other site 713604002291 Q-loop/lid; other site 713604002292 ABC transporter signature motif; other site 713604002293 Walker B; other site 713604002294 D-loop; other site 713604002295 H-loop/switch region; other site 713604002296 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604002297 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604002298 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 713604002299 TM-ABC transporter signature motif; other site 713604002300 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604002301 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 713604002302 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 713604002303 TM-ABC transporter signature motif; other site 713604002304 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 713604002305 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 713604002306 active site 713604002307 catalytic motif [active] 713604002308 Zn binding site [ion binding]; other site 713604002309 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 713604002310 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 713604002311 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 713604002312 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 713604002313 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 713604002314 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 713604002315 adenosine deaminase; Provisional; Region: PRK09358 713604002316 active site 713604002317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604002319 putative substrate translocation pore; other site 713604002320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604002321 ATP binding site [chemical binding]; other site 713604002322 putative Mg++ binding site [ion binding]; other site 713604002323 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604002324 nucleotide binding region [chemical binding]; other site 713604002325 ATP-binding site [chemical binding]; other site 713604002326 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 713604002327 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 713604002328 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604002329 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604002330 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 713604002331 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 713604002332 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604002333 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 713604002334 putative NAD(P) binding site [chemical binding]; other site 713604002335 catalytic Zn binding site [ion binding]; other site 713604002336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604002337 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604002338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604002339 dimer interface [polypeptide binding]; other site 713604002340 conserved gate region; other site 713604002341 putative PBP binding loops; other site 713604002342 ABC-ATPase subunit interface; other site 713604002343 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604002344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604002345 dimer interface [polypeptide binding]; other site 713604002346 conserved gate region; other site 713604002347 putative PBP binding loops; other site 713604002348 ABC-ATPase subunit interface; other site 713604002349 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 713604002350 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604002351 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604002352 Cytochrome P450; Region: p450; cl12078 713604002353 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604002354 Cytochrome P450; Region: p450; cl12078 713604002355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002357 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 713604002358 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604002359 NAD(P) binding site [chemical binding]; other site 713604002360 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 713604002361 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604002362 NAD(P) binding site [chemical binding]; other site 713604002363 catalytic residues [active] 713604002364 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 713604002365 intersubunit interface [polypeptide binding]; other site 713604002366 active site 713604002367 catalytic residue [active] 713604002368 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604002369 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 713604002370 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 713604002371 active site 713604002372 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604002373 active site 713604002374 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 713604002375 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604002376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604002377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002379 WHG domain; Region: WHG; pfam13305 713604002380 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604002381 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 713604002382 DNA binding residues [nucleotide binding] 713604002383 putative dimer interface [polypeptide binding]; other site 713604002384 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604002385 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604002386 active site 713604002387 catalytic tetrad [active] 713604002388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604002389 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 713604002390 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 713604002391 active site 713604002392 substrate binding site [chemical binding]; other site 713604002393 FMN binding site [chemical binding]; other site 713604002394 putative catalytic residues [active] 713604002395 Cytochrome P450; Region: p450; cl12078 713604002396 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 713604002397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604002398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002399 active site 713604002400 phosphorylation site [posttranslational modification] 713604002401 intermolecular recognition site; other site 713604002402 dimerization interface [polypeptide binding]; other site 713604002403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604002404 DNA binding site [nucleotide binding] 713604002405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604002406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604002407 dimer interface [polypeptide binding]; other site 713604002408 phosphorylation site [posttranslational modification] 713604002409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604002410 ATP binding site [chemical binding]; other site 713604002411 Mg2+ binding site [ion binding]; other site 713604002412 G-X-G motif; other site 713604002413 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 713604002414 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 713604002415 dimer interface [polypeptide binding]; other site 713604002416 motif 1; other site 713604002417 active site 713604002418 motif 2; other site 713604002419 motif 3; other site 713604002420 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 713604002421 anticodon binding site; other site 713604002422 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604002423 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604002424 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604002425 active site 713604002426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604002427 non-specific DNA binding site [nucleotide binding]; other site 713604002428 salt bridge; other site 713604002429 sequence-specific DNA binding site [nucleotide binding]; other site 713604002430 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 713604002431 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604002432 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 713604002433 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 713604002434 active site 713604002435 substrate binding site [chemical binding]; other site 713604002436 metal binding site [ion binding]; metal-binding site 713604002437 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604002438 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604002439 homodimer interface [polypeptide binding]; other site 713604002440 active site 713604002441 TDP-binding site; other site 713604002442 acceptor substrate-binding pocket; other site 713604002443 purine nucleoside phosphorylase; Provisional; Region: PRK08202 713604002444 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 713604002445 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604002446 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604002447 DNA binding residues [nucleotide binding] 713604002448 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604002449 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604002450 active site 713604002451 ATP binding site [chemical binding]; other site 713604002452 substrate binding site [chemical binding]; other site 713604002453 activation loop (A-loop); other site 713604002454 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 713604002455 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 713604002456 heterodimer interface [polypeptide binding]; other site 713604002457 substrate interaction site [chemical binding]; other site 713604002458 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 713604002459 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 713604002460 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 713604002461 active site 713604002462 substrate binding site [chemical binding]; other site 713604002463 coenzyme B12 binding site [chemical binding]; other site 713604002464 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 713604002465 B12 binding site [chemical binding]; other site 713604002466 cobalt ligand [ion binding]; other site 713604002467 membrane ATPase/protein kinase; Provisional; Region: PRK09435 713604002468 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 713604002469 Walker A; other site 713604002470 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 713604002471 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 713604002472 metal binding site [ion binding]; metal-binding site 713604002473 putative dimer interface [polypeptide binding]; other site 713604002474 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 713604002475 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 713604002476 putative active site [active] 713604002477 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 713604002478 dimerization interface [polypeptide binding]; other site 713604002479 putative active site pocket [active] 713604002480 putative catalytic residue [active] 713604002481 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 713604002482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604002483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604002484 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604002485 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604002486 active site 713604002487 putative catalytic site [active] 713604002488 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604002489 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604002490 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604002491 glycerol kinase; Provisional; Region: glpK; PRK00047 713604002492 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 713604002493 N- and C-terminal domain interface [polypeptide binding]; other site 713604002494 active site 713604002495 MgATP binding site [chemical binding]; other site 713604002496 catalytic site [active] 713604002497 metal binding site [ion binding]; metal-binding site 713604002498 putative homotetramer interface [polypeptide binding]; other site 713604002499 glycerol binding site [chemical binding]; other site 713604002500 homodimer interface [polypeptide binding]; other site 713604002501 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 713604002502 amphipathic channel; other site 713604002503 Asn-Pro-Ala signature motifs; other site 713604002504 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 713604002505 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604002506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002507 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 713604002508 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 713604002509 putative NAD(P) binding site [chemical binding]; other site 713604002510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604002511 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604002512 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604002513 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 713604002514 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604002515 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 713604002516 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 713604002517 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604002518 carboxyltransferase (CT) interaction site; other site 713604002519 biotinylation site [posttranslational modification]; other site 713604002520 2,4-diaminobutyrate 4-transaminases; Region: dat; TIGR00709 713604002521 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 713604002522 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 713604002523 Maf-like protein; Region: Maf; pfam02545 713604002524 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 713604002525 active site 713604002526 dimer interface [polypeptide binding]; other site 713604002527 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604002528 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604002529 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604002530 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604002531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002532 putative substrate translocation pore; other site 713604002533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002534 putative substrate translocation pore; other site 713604002535 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604002536 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604002537 TROVE domain; Region: TROVE; pfam05731 713604002538 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604002539 metal ion-dependent adhesion site (MIDAS); other site 713604002540 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604002541 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604002542 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604002543 MarR family; Region: MarR_2; pfam12802 713604002544 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 713604002545 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 713604002546 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 713604002547 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604002548 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 713604002549 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002551 active site 713604002552 phosphorylation site [posttranslational modification] 713604002553 intermolecular recognition site; other site 713604002554 dimerization interface [polypeptide binding]; other site 713604002555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002556 DNA binding residues [nucleotide binding] 713604002557 dimerization interface [polypeptide binding]; other site 713604002558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604002559 Histidine kinase; Region: HisKA_3; pfam07730 713604002560 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604002561 Mg2+ binding site [ion binding]; other site 713604002562 G-X-G motif; other site 713604002563 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 713604002564 putative hydrophobic ligand binding site [chemical binding]; other site 713604002565 MarR family; Region: MarR_2; pfam12802 713604002566 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 713604002567 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604002568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002570 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604002571 hypothetical protein; Provisional; Region: PRK07588 713604002572 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604002573 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604002574 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 713604002575 short chain dehydrogenase; Provisional; Region: PRK06500 713604002576 classical (c) SDRs; Region: SDR_c; cd05233 713604002577 NAD(P) binding site [chemical binding]; other site 713604002578 active site 713604002579 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604002580 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604002581 conserved cys residue [active] 713604002582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604002583 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 713604002584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604002585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604002586 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604002587 dimerization interface [polypeptide binding]; other site 713604002588 substrate binding pocket [chemical binding]; other site 713604002589 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604002590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002592 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604002593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604002594 S-adenosylmethionine binding site [chemical binding]; other site 713604002595 RibD C-terminal domain; Region: RibD_C; cl17279 713604002596 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604002597 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604002598 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 713604002599 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 713604002600 FMN binding site [chemical binding]; other site 713604002601 active site 713604002602 substrate binding site [chemical binding]; other site 713604002603 catalytic residue [active] 713604002604 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604002605 active site 713604002606 metal binding site [ion binding]; metal-binding site 713604002607 Histidine kinase; Region: HisKA_3; pfam07730 713604002608 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604002609 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002611 active site 713604002612 phosphorylation site [posttranslational modification] 713604002613 intermolecular recognition site; other site 713604002614 dimerization interface [polypeptide binding]; other site 713604002615 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002616 DNA binding residues [nucleotide binding] 713604002617 dimerization interface [polypeptide binding]; other site 713604002618 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604002619 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604002620 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 713604002621 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 713604002622 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 713604002623 Bacterial PH domain; Region: DUF304; pfam03703 713604002624 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 713604002625 active site 713604002626 catalytic residues [active] 713604002627 metal binding site [ion binding]; metal-binding site 713604002628 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 713604002629 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604002630 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604002631 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 713604002632 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 713604002633 active site 713604002634 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604002635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002636 active site 713604002637 phosphorylation site [posttranslational modification] 713604002638 intermolecular recognition site; other site 713604002639 dimerization interface [polypeptide binding]; other site 713604002640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604002641 DNA binding site [nucleotide binding] 713604002642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604002643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604002644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604002645 ATP binding site [chemical binding]; other site 713604002646 Mg2+ binding site [ion binding]; other site 713604002647 G-X-G motif; other site 713604002648 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002650 DNA binding residues [nucleotide binding] 713604002651 dimerization interface [polypeptide binding]; other site 713604002652 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002654 active site 713604002655 phosphorylation site [posttranslational modification] 713604002656 intermolecular recognition site; other site 713604002657 dimerization interface [polypeptide binding]; other site 713604002658 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002659 DNA binding residues [nucleotide binding] 713604002660 dimerization interface [polypeptide binding]; other site 713604002661 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604002662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604002663 NAD(P) binding site [chemical binding]; other site 713604002664 active site 713604002665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002666 putative substrate translocation pore; other site 713604002667 Predicted membrane protein [Function unknown]; Region: COG2246 713604002668 GtrA-like protein; Region: GtrA; pfam04138 713604002669 GtrA-like protein; Region: GtrA; pfam04138 713604002670 Predicted membrane protein [Function unknown]; Region: COG2246 713604002671 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604002672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604002673 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604002674 DNA binding residues [nucleotide binding] 713604002675 Putative zinc-finger; Region: zf-HC2; pfam13490 713604002676 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 713604002677 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 713604002678 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 713604002679 ATP-grasp domain; Region: ATP-grasp; pfam02222 713604002680 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 713604002681 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604002682 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604002683 acyl-activating enzyme (AAE) consensus motif; other site 713604002684 AMP binding site [chemical binding]; other site 713604002685 active site 713604002686 CoA binding site [chemical binding]; other site 713604002687 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604002688 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604002689 active site 713604002690 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 713604002691 Lipase (class 2); Region: Lipase_2; pfam01674 713604002692 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604002693 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 713604002694 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 713604002695 Predicted membrane protein [Function unknown]; Region: COG2259 713604002696 TIGR03089 family protein; Region: TIGR03089 713604002697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604002698 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604002699 NAD(P) binding site [chemical binding]; other site 713604002700 active site 713604002701 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604002702 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604002703 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 713604002704 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 713604002705 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 713604002706 NAD binding site [chemical binding]; other site 713604002707 substrate binding site [chemical binding]; other site 713604002708 homodimer interface [polypeptide binding]; other site 713604002709 active site 713604002710 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 713604002711 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 713604002712 NADP binding site [chemical binding]; other site 713604002713 active site 713604002714 putative substrate binding site [chemical binding]; other site 713604002715 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 713604002716 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604002717 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604002718 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 713604002719 Probable Catalytic site; other site 713604002720 metal-binding site 713604002721 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604002722 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604002723 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604002724 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 713604002725 Probable Catalytic site; other site 713604002726 metal-binding site 713604002727 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 713604002728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604002729 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604002730 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 713604002731 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 713604002732 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604002733 Probable Catalytic site; other site 713604002734 metal-binding site 713604002735 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 713604002736 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 713604002737 active site 713604002738 Substrate binding site; other site 713604002739 Mg++ binding site; other site 713604002740 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604002741 putative CoA binding site [chemical binding]; other site 713604002742 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 713604002743 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 713604002744 minor groove reading motif; other site 713604002745 helix-hairpin-helix signature motif; other site 713604002746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604002747 DNA-binding site [nucleotide binding]; DNA binding site 713604002748 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 713604002749 nudix motif; other site 713604002750 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 713604002751 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 713604002752 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 713604002753 putative FMN binding site [chemical binding]; other site 713604002754 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 713604002755 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 713604002756 dimer interface [polypeptide binding]; other site 713604002757 phosphate binding site [ion binding]; other site 713604002758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604002759 Coenzyme A binding pocket [chemical binding]; other site 713604002760 Ferredoxin [Energy production and conversion]; Region: COG1146 713604002761 4Fe-4S binding domain; Region: Fer4; pfam00037 713604002762 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 713604002763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604002764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604002765 homodimer interface [polypeptide binding]; other site 713604002766 catalytic residue [active] 713604002767 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002768 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002769 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604002770 hypothetical protein; Provisional; Region: PRK06184 713604002771 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604002772 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 713604002773 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 713604002774 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604002775 putative trimer interface [polypeptide binding]; other site 713604002776 putative CoA binding site [chemical binding]; other site 713604002777 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 713604002778 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 713604002779 metal binding site [ion binding]; metal-binding site 713604002780 putative dimer interface [polypeptide binding]; other site 713604002781 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 713604002782 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 713604002783 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 713604002784 putative active site [active] 713604002785 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 713604002786 Peptidase family M28; Region: Peptidase_M28; pfam04389 713604002787 active site 713604002788 metal binding site [ion binding]; metal-binding site 713604002789 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 713604002790 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 713604002791 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 713604002792 active site 713604002793 Zn binding site [ion binding]; other site 713604002794 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 713604002795 Helix-turn-helix domain; Region: HTH_19; pfam12844 713604002796 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 713604002797 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 713604002798 active site 713604002799 Zn binding site [ion binding]; other site 713604002800 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 713604002801 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604002802 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604002803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604002804 non-specific DNA binding site [nucleotide binding]; other site 713604002805 salt bridge; other site 713604002806 sequence-specific DNA binding site [nucleotide binding]; other site 713604002807 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604002808 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 713604002809 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 713604002810 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604002811 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604002812 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604002813 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 713604002814 Probable Catalytic site; other site 713604002815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002816 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 713604002817 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 713604002818 Methyltransferase domain; Region: Methyltransf_24; pfam13578 713604002819 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604002820 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604002821 putative acyl-acceptor binding pocket; other site 713604002822 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 713604002823 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 713604002824 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 713604002825 Walker A/P-loop; other site 713604002826 ATP binding site [chemical binding]; other site 713604002827 Q-loop/lid; other site 713604002828 ABC transporter signature motif; other site 713604002829 Walker B; other site 713604002830 D-loop; other site 713604002831 H-loop/switch region; other site 713604002832 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 713604002833 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 713604002834 Walker A/P-loop; other site 713604002835 ATP binding site [chemical binding]; other site 713604002836 Q-loop/lid; other site 713604002837 ABC transporter signature motif; other site 713604002838 Walker B; other site 713604002839 D-loop; other site 713604002840 H-loop/switch region; other site 713604002841 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 713604002842 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 713604002843 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 713604002844 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 713604002845 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604002846 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604002847 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604002848 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604002849 hydrophobic ligand binding site; other site 713604002850 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 713604002851 enoyl-CoA hydratase; Provisional; Region: PRK08140 713604002852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604002853 substrate binding site [chemical binding]; other site 713604002854 oxyanion hole (OAH) forming residues; other site 713604002855 trimer interface [polypeptide binding]; other site 713604002856 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 713604002857 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 713604002858 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 713604002859 interface (dimer of trimers) [polypeptide binding]; other site 713604002860 Substrate-binding/catalytic site; other site 713604002861 Zn-binding sites [ion binding]; other site 713604002862 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 713604002863 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604002864 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 713604002865 putative dimerization interface [polypeptide binding]; other site 713604002866 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604002867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002868 putative substrate translocation pore; other site 713604002869 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604002870 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604002871 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604002872 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 713604002873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604002874 S-adenosylmethionine binding site [chemical binding]; other site 713604002875 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 713604002876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604002877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604002878 DNA binding residues [nucleotide binding] 713604002879 Putative zinc-finger; Region: zf-HC2; pfam13490 713604002880 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604002881 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604002882 sec-independent translocase; Provisional; Region: PRK03100 713604002883 Domain of unknown function DUF59; Region: DUF59; cl00941 713604002884 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 713604002885 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 713604002886 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604002887 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 713604002888 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 713604002889 PRC-barrel domain; Region: PRC; pfam05239 713604002890 MgtE intracellular N domain; Region: MgtE_N; smart00924 713604002891 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 713604002892 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 713604002893 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 713604002894 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 713604002895 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 713604002896 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 713604002897 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604002898 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604002899 active site 713604002900 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604002901 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604002902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604002903 dimer interface [polypeptide binding]; other site 713604002904 conserved gate region; other site 713604002905 putative PBP binding loops; other site 713604002906 ABC-ATPase subunit interface; other site 713604002907 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604002908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604002909 dimer interface [polypeptide binding]; other site 713604002910 conserved gate region; other site 713604002911 putative PBP binding loops; other site 713604002912 ABC-ATPase subunit interface; other site 713604002913 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 713604002914 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 713604002915 Walker A/P-loop; other site 713604002916 ATP binding site [chemical binding]; other site 713604002917 Q-loop/lid; other site 713604002918 ABC transporter signature motif; other site 713604002919 Walker B; other site 713604002920 D-loop; other site 713604002921 H-loop/switch region; other site 713604002922 PspC domain; Region: PspC; pfam04024 713604002923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002925 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 713604002926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604002927 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604002928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604002929 active site 713604002930 phosphorylation site [posttranslational modification] 713604002931 intermolecular recognition site; other site 713604002932 dimerization interface [polypeptide binding]; other site 713604002933 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604002934 DNA binding residues [nucleotide binding] 713604002935 dimerization interface [polypeptide binding]; other site 713604002936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604002937 Histidine kinase; Region: HisKA_3; pfam07730 713604002938 CAAX protease self-immunity; Region: Abi; pfam02517 713604002939 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604002940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604002941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604002942 DNA binding residues [nucleotide binding] 713604002943 ParB-like nuclease domain; Region: ParBc; cl02129 713604002944 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604002945 active site 713604002946 metal binding site [ion binding]; metal-binding site 713604002947 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604002948 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 713604002949 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 713604002950 oligomer interface [polypeptide binding]; other site 713604002951 metal binding site [ion binding]; metal-binding site 713604002952 metal binding site [ion binding]; metal-binding site 713604002953 putative Cl binding site [ion binding]; other site 713604002954 basic sphincter; other site 713604002955 hydrophobic gate; other site 713604002956 periplasmic entrance; other site 713604002957 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 713604002958 putative active site [active] 713604002959 putative catalytic site [active] 713604002960 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 713604002961 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 713604002962 nudix motif; other site 713604002963 Bacterial PH domain; Region: DUF304; pfam03703 713604002964 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 713604002965 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 713604002966 active site 713604002967 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 713604002968 MarC family integral membrane protein; Region: MarC; cl00919 713604002969 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604002970 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604002971 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 713604002972 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 713604002973 DEAD-like helicases superfamily; Region: DEXDc; smart00487 713604002974 ATP binding site [chemical binding]; other site 713604002975 Mg++ binding site [ion binding]; other site 713604002976 motif III; other site 713604002977 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604002978 nucleotide binding region [chemical binding]; other site 713604002979 ATP-binding site [chemical binding]; other site 713604002980 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 713604002981 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 713604002982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002984 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 713604002985 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604002986 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604002987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604002988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604002989 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604002990 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 713604002991 catalytic site [active] 713604002992 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 713604002993 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 713604002994 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 713604002995 ATP binding site [chemical binding]; other site 713604002996 substrate interface [chemical binding]; other site 713604002997 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 713604002998 active site residue [active] 713604002999 TIGR02569 family protein; Region: TIGR02569_actnb 713604003000 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 713604003001 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 713604003002 [4Fe-4S] binding site [ion binding]; other site 713604003003 molybdopterin cofactor binding site; other site 713604003004 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 713604003005 molybdopterin cofactor binding site; other site 713604003006 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604003007 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604003008 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 713604003009 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 713604003010 nitrite reductase subunit NirD; Provisional; Region: PRK14989 713604003011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604003012 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 713604003013 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 713604003014 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713604003015 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 713604003016 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 713604003017 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 713604003018 active site 713604003019 DNA binding site [nucleotide binding] 713604003020 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604003021 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604003022 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604003023 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 713604003024 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604003025 HTH domain; Region: HTH_11; pfam08279 713604003026 WYL domain; Region: WYL; pfam13280 713604003027 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 713604003028 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 713604003029 active site 713604003030 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 713604003031 DNA binding site [nucleotide binding] 713604003032 active site 713604003033 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 713604003034 Part of AAA domain; Region: AAA_19; pfam13245 713604003035 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 713604003036 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 713604003037 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 713604003038 Part of AAA domain; Region: AAA_19; pfam13245 713604003039 Family description; Region: UvrD_C_2; pfam13538 713604003040 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 713604003041 Predicted membrane protein [Function unknown]; Region: COG4270 713604003042 Ion channel; Region: Ion_trans_2; pfam07885 713604003043 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 713604003044 TrkA-N domain; Region: TrkA_N; pfam02254 713604003045 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604003046 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 713604003047 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 713604003048 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 713604003049 MoxR-like ATPases [General function prediction only]; Region: COG0714 713604003050 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 713604003051 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 713604003052 Protein of unknown function DUF58; Region: DUF58; pfam01882 713604003053 Integral membrane protein DUF95; Region: DUF95; pfam01944 713604003054 Predicted membrane protein/domain [Function unknown]; Region: COG1714 713604003055 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604003056 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604003057 active site 713604003058 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604003059 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 713604003060 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 713604003061 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 713604003062 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 713604003063 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 713604003064 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 713604003065 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 713604003066 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 713604003067 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 713604003068 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 713604003069 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 713604003070 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 713604003071 putative NADH binding site [chemical binding]; other site 713604003072 putative active site [active] 713604003073 nudix motif; other site 713604003074 putative metal binding site [ion binding]; other site 713604003075 MarR family; Region: MarR_2; pfam12802 713604003076 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604003077 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604003078 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604003079 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604003080 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604003081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604003082 dimer interface [polypeptide binding]; other site 713604003083 putative PBP binding loops; other site 713604003084 ABC-ATPase subunit interface; other site 713604003085 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604003086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604003087 dimer interface [polypeptide binding]; other site 713604003088 conserved gate region; other site 713604003089 putative PBP binding loops; other site 713604003090 ABC-ATPase subunit interface; other site 713604003091 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 713604003092 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 713604003093 NAD binding site [chemical binding]; other site 713604003094 sugar binding site [chemical binding]; other site 713604003095 divalent metal binding site [ion binding]; other site 713604003096 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604003097 dimer interface [polypeptide binding]; other site 713604003098 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 713604003099 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 713604003100 putative hydrophobic ligand binding site [chemical binding]; other site 713604003101 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604003102 dimerization interface [polypeptide binding]; other site 713604003103 putative DNA binding site [nucleotide binding]; other site 713604003104 putative Zn2+ binding site [ion binding]; other site 713604003105 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 713604003106 GntP family permease; Region: GntP_permease; pfam02447 713604003107 fructuronate transporter; Provisional; Region: PRK10034; cl15264 713604003108 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 713604003109 ATP-binding site [chemical binding]; other site 713604003110 Gluconate-6-phosphate binding site [chemical binding]; other site 713604003111 Shikimate kinase; Region: SKI; pfam01202 713604003112 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604003113 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604003114 DNA-binding site [nucleotide binding]; DNA binding site 713604003115 FCD domain; Region: FCD; pfam07729 713604003116 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 713604003117 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 713604003118 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 713604003119 Low molecular weight phosphatase family; Region: LMWPc; cd00115 713604003120 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 713604003121 active site 713604003122 chorismate mutase; Provisional; Region: PRK09269 713604003123 Chorismate mutase type II; Region: CM_2; cl00693 713604003124 Uncharacterized conserved protein [Function unknown]; Region: COG0327 713604003125 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 713604003126 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 713604003127 Putative zinc ribbon domain; Region: DUF164; pfam02591 713604003128 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 713604003129 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 713604003130 RNA/DNA hybrid binding site [nucleotide binding]; other site 713604003131 active site 713604003132 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604003133 catalytic core [active] 713604003134 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 713604003135 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 713604003136 transmembrane helices; other site 713604003137 AAA ATPase domain; Region: AAA_16; pfam13191 713604003138 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604003140 TPR motif; other site 713604003141 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003142 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003143 DNA binding residues [nucleotide binding] 713604003144 dimerization interface [polypeptide binding]; other site 713604003145 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 713604003146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604003147 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604003148 DNA binding residues [nucleotide binding] 713604003149 Domain of unknown function (DUF4142); Region: DUF4142; cl17876 713604003150 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 713604003151 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604003152 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604003153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604003154 AAA-like domain; Region: AAA_10; pfam12846 713604003155 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604003156 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604003157 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 713604003158 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604003159 RNB domain; Region: RNB; pfam00773 713604003160 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 713604003161 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 713604003162 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 713604003163 intersubunit interface [polypeptide binding]; other site 713604003164 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 713604003165 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604003166 NAD(P) binding site [chemical binding]; other site 713604003167 catalytic residues [active] 713604003168 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 713604003169 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604003170 inhibitor-cofactor binding pocket; inhibition site 713604003171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604003172 catalytic residue [active] 713604003173 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 713604003174 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604003175 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604003176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604003177 DNA-binding site [nucleotide binding]; DNA binding site 713604003178 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 713604003179 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 713604003180 tetrameric interface [polypeptide binding]; other site 713604003181 NAD binding site [chemical binding]; other site 713604003182 catalytic residues [active] 713604003183 substrate binding site [chemical binding]; other site 713604003184 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 713604003185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003186 Walker A/P-loop; other site 713604003187 ATP binding site [chemical binding]; other site 713604003188 Q-loop/lid; other site 713604003189 ABC transporter signature motif; other site 713604003190 Walker B; other site 713604003191 D-loop; other site 713604003192 H-loop/switch region; other site 713604003193 TOBE domain; Region: TOBE_2; pfam08402 713604003194 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604003195 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604003196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604003197 dimer interface [polypeptide binding]; other site 713604003198 conserved gate region; other site 713604003199 putative PBP binding loops; other site 713604003200 ABC-ATPase subunit interface; other site 713604003201 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 713604003202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604003203 dimer interface [polypeptide binding]; other site 713604003204 conserved gate region; other site 713604003205 putative PBP binding loops; other site 713604003206 ABC-ATPase subunit interface; other site 713604003207 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 713604003208 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 713604003209 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 713604003210 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 713604003211 oligomerization interface [polypeptide binding]; other site 713604003212 active site 713604003213 metal binding site [ion binding]; metal-binding site 713604003214 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 713604003215 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 713604003216 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 713604003217 dimer interface [polypeptide binding]; other site 713604003218 putative anticodon binding site; other site 713604003219 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604003220 motif 1; other site 713604003221 dimer interface [polypeptide binding]; other site 713604003222 active site 713604003223 motif 2; other site 713604003224 motif 3; other site 713604003225 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604003226 DinB superfamily; Region: DinB_2; pfam12867 713604003227 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 713604003228 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 713604003229 DNA binding site [nucleotide binding] 713604003230 active site 713604003231 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 713604003232 NAD synthetase; Provisional; Region: PRK13981 713604003233 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 713604003234 multimer interface [polypeptide binding]; other site 713604003235 active site 713604003236 catalytic triad [active] 713604003237 protein interface 1 [polypeptide binding]; other site 713604003238 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 713604003239 homodimer interface [polypeptide binding]; other site 713604003240 NAD binding pocket [chemical binding]; other site 713604003241 ATP binding pocket [chemical binding]; other site 713604003242 Mg binding site [ion binding]; other site 713604003243 active-site loop [active] 713604003244 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 713604003245 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 713604003246 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604003247 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604003248 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 713604003249 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604003250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604003251 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 713604003252 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 713604003253 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604003254 amidase; Provisional; Region: PRK08137 713604003255 Amidase; Region: Amidase; pfam01425 713604003256 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604003257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604003258 putative DNA binding site [nucleotide binding]; other site 713604003259 putative Zn2+ binding site [ion binding]; other site 713604003260 AsnC family; Region: AsnC_trans_reg; pfam01037 713604003261 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 713604003262 active site residue [active] 713604003263 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 713604003264 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 713604003265 catalytic triad [active] 713604003266 Phosphate transporter family; Region: PHO4; cl00396 713604003267 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 713604003268 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 713604003269 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 713604003270 metal binding triad; other site 713604003271 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 713604003272 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 713604003273 metal binding triad; other site 713604003274 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 713604003275 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 713604003276 active site 713604003277 glutamine synthetase, type I; Region: GlnA; TIGR00653 713604003278 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 713604003279 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604003280 RDD family; Region: RDD; pfam06271 713604003281 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 713604003282 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 713604003283 Part of AAA domain; Region: AAA_19; pfam13245 713604003284 Family description; Region: UvrD_C_2; pfam13538 713604003285 HRDC domain; Region: HRDC; pfam00570 713604003286 Transcription factor WhiB; Region: Whib; pfam02467 713604003287 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604003288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604003289 S-adenosylmethionine binding site [chemical binding]; other site 713604003290 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 713604003291 ABC1 family; Region: ABC1; pfam03109 713604003292 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 713604003293 active site 713604003294 ATP binding site [chemical binding]; other site 713604003295 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 713604003296 catalytic loop [active] 713604003297 activation loop (A-loop); other site 713604003298 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 713604003299 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 713604003300 Protein of unknown function DUF45; Region: DUF45; cl00636 713604003301 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 713604003302 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 713604003303 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 713604003304 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604003305 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 713604003306 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 713604003307 hypothetical protein; Validated; Region: PRK00068 713604003308 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604003309 hypothetical protein; Provisional; Region: PRK08244 713604003310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003311 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604003312 peptide chain release factor 2; Validated; Region: prfB; PRK00578 713604003313 This domain is found in peptide chain release factors; Region: PCRF; smart00937 713604003314 RF-1 domain; Region: RF-1; pfam00472 713604003315 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 713604003316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003317 Walker A/P-loop; other site 713604003318 ATP binding site [chemical binding]; other site 713604003319 Q-loop/lid; other site 713604003320 ABC transporter signature motif; other site 713604003321 Walker B; other site 713604003322 D-loop; other site 713604003323 H-loop/switch region; other site 713604003324 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 713604003325 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 713604003326 SmpB-tmRNA interface; other site 713604003327 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 713604003328 active site 713604003329 Acyltransferase family; Region: Acyl_transf_3; pfam01757 713604003330 Domain of unknown function (DUF336); Region: DUF336; cl01249 713604003331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604003333 active site 713604003334 phosphorylation site [posttranslational modification] 713604003335 intermolecular recognition site; other site 713604003336 dimerization interface [polypeptide binding]; other site 713604003337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003338 DNA binding residues [nucleotide binding] 713604003339 dimerization interface [polypeptide binding]; other site 713604003340 Putative sensor; Region: Sensor; pfam13796 713604003341 Histidine kinase; Region: HisKA_3; pfam07730 713604003342 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604003343 Mg2+ binding site [ion binding]; other site 713604003344 G-X-G motif; other site 713604003345 Putative sensor; Region: Sensor; pfam13796 713604003346 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604003347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604003348 metal binding site [ion binding]; metal-binding site 713604003349 active site 713604003350 I-site; other site 713604003351 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604003352 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604003353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604003354 putative DNA binding site [nucleotide binding]; other site 713604003355 putative Zn2+ binding site [ion binding]; other site 713604003356 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604003357 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 713604003358 active sites [active] 713604003359 tetramer interface [polypeptide binding]; other site 713604003360 urocanate hydratase; Provisional; Region: PRK05414 713604003361 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 713604003362 allantoate amidohydrolase; Reviewed; Region: PRK09290 713604003363 active site 713604003364 metal binding site [ion binding]; metal-binding site 713604003365 dimer interface [polypeptide binding]; other site 713604003366 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 713604003367 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604003368 active site 713604003369 imidazolonepropionase; Provisional; Region: PRK14085 713604003370 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604003371 active site 713604003372 hypothetical protein; Provisional; Region: PRK06847 713604003373 hypothetical protein; Provisional; Region: PRK07236 713604003374 Lipase (class 2); Region: Lipase_2; pfam01674 713604003375 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 713604003376 active site 713604003377 catalytic triad [active] 713604003378 dimer interface [polypeptide binding]; other site 713604003379 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 713604003380 Histidine kinase; Region: HisKA_3; pfam07730 713604003381 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604003382 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604003384 active site 713604003385 phosphorylation site [posttranslational modification] 713604003386 intermolecular recognition site; other site 713604003387 dimerization interface [polypeptide binding]; other site 713604003388 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003389 DNA binding residues [nucleotide binding] 713604003390 dimerization interface [polypeptide binding]; other site 713604003391 hypothetical protein; Provisional; Region: PRK06753 713604003392 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604003393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 713604003394 cyclase homology domain; Region: CHD; cd07302 713604003395 nucleotidyl binding site; other site 713604003396 metal binding site [ion binding]; metal-binding site 713604003397 dimer interface [polypeptide binding]; other site 713604003398 NB-ARC domain; Region: NB-ARC; pfam00931 713604003399 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003400 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003401 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604003403 binding surface 713604003404 TPR motif; other site 713604003405 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003406 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003407 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604003408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003409 Walker A/P-loop; other site 713604003410 ATP binding site [chemical binding]; other site 713604003411 Q-loop/lid; other site 713604003412 ABC transporter signature motif; other site 713604003413 Walker B; other site 713604003414 D-loop; other site 713604003415 H-loop/switch region; other site 713604003416 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 713604003417 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 713604003418 ATP binding site [chemical binding]; other site 713604003419 putative Mg++ binding site [ion binding]; other site 713604003420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604003421 nucleotide binding region [chemical binding]; other site 713604003422 ATP-binding site [chemical binding]; other site 713604003423 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 713604003424 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 713604003425 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604003426 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604003427 substrate binding pocket [chemical binding]; other site 713604003428 membrane-bound complex binding site; other site 713604003429 hinge residues; other site 713604003430 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 713604003431 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 713604003432 catalytic residues [active] 713604003433 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604003434 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604003435 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 713604003436 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 713604003437 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604003438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604003439 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604003440 DinB superfamily; Region: DinB_2; pfam12867 713604003441 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604003442 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604003443 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604003444 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 713604003445 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604003446 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604003447 putative sugar binding sites [chemical binding]; other site 713604003448 Q-X-W motif; other site 713604003449 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 713604003450 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 713604003451 CAP-like domain; other site 713604003452 active site 713604003453 primary dimer interface [polypeptide binding]; other site 713604003454 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 713604003455 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 713604003456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604003457 ATP binding site [chemical binding]; other site 713604003458 Mg2+ binding site [ion binding]; other site 713604003459 G-X-G motif; other site 713604003460 DNA gyrase B; Region: DNA_gyraseB; pfam00204 713604003461 ATP binding site [chemical binding]; other site 713604003462 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 713604003463 active site 713604003464 metal binding site [ion binding]; metal-binding site 713604003465 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 713604003466 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 713604003467 homodimer interface [polypeptide binding]; other site 713604003468 putative active site [active] 713604003469 catalytic site [active] 713604003470 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 713604003471 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604003472 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604003473 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604003474 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 713604003475 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604003476 RibD C-terminal domain; Region: RibD_C; cl17279 713604003477 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604003478 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604003479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003481 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604003482 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604003483 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604003484 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604003485 intermolecular salt bridges; other site 713604003486 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604003487 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604003488 TM-ABC transporter signature motif; other site 713604003489 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604003490 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604003491 TM-ABC transporter signature motif; other site 713604003492 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 713604003493 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604003494 Walker A/P-loop; other site 713604003495 ATP binding site [chemical binding]; other site 713604003496 Q-loop/lid; other site 713604003497 ABC transporter signature motif; other site 713604003498 Walker B; other site 713604003499 D-loop; other site 713604003500 H-loop/switch region; other site 713604003501 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604003502 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 713604003503 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604003504 putative ligand binding site [chemical binding]; other site 713604003505 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604003506 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604003507 DNA binding site [nucleotide binding] 713604003508 domain linker motif; other site 713604003509 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604003510 ligand binding site [chemical binding]; other site 713604003511 dimerization interface [polypeptide binding]; other site 713604003512 Predicted ATPase [General function prediction only]; Region: COG4637 713604003513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003514 Walker A/P-loop; other site 713604003515 ATP binding site [chemical binding]; other site 713604003516 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604003517 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604003518 short chain dehydrogenase; Validated; Region: PRK08264 713604003519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604003520 NAD(P) binding site [chemical binding]; other site 713604003521 active site 713604003522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003524 WHG domain; Region: WHG; pfam13305 713604003525 Phosphotransferase enzyme family; Region: APH; pfam01636 713604003526 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604003527 active site 713604003528 ATP binding site [chemical binding]; other site 713604003529 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604003530 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 713604003531 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 713604003532 FAD binding pocket [chemical binding]; other site 713604003533 FAD binding motif [chemical binding]; other site 713604003534 phosphate binding motif [ion binding]; other site 713604003535 NAD binding pocket [chemical binding]; other site 713604003536 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 713604003537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003538 Walker A/P-loop; other site 713604003539 ATP binding site [chemical binding]; other site 713604003540 Q-loop/lid; other site 713604003541 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 713604003542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003543 Walker A/P-loop; other site 713604003544 ATP binding site [chemical binding]; other site 713604003545 Q-loop/lid; other site 713604003546 ABC transporter signature motif; other site 713604003547 Walker B; other site 713604003548 D-loop; other site 713604003549 H-loop/switch region; other site 713604003550 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604003551 Methyltransferase domain; Region: Methyltransf_11; pfam08241 713604003552 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604003553 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 713604003554 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604003555 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 713604003556 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 713604003557 substrate binding pocket [chemical binding]; other site 713604003558 substrate-Mg2+ binding site; other site 713604003559 aspartate-rich region 1; other site 713604003560 active site lid residues [active] 713604003561 aspartate-rich region 2; other site 713604003562 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 713604003563 substrate binding pocket [chemical binding]; other site 713604003564 substrate-Mg2+ binding site; other site 713604003565 aspartate-rich region 1; other site 713604003566 aspartate-rich region 2; other site 713604003567 Predicted acetyltransferase [General function prediction only]; Region: COG2388 713604003568 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604003569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604003570 S-adenosylmethionine binding site [chemical binding]; other site 713604003571 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604003572 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604003573 putative sugar binding sites [chemical binding]; other site 713604003574 Q-X-W motif; other site 713604003575 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604003576 classical (c) SDRs; Region: SDR_c; cd05233 713604003577 NAD(P) binding site [chemical binding]; other site 713604003578 active site 713604003579 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604003580 Cytochrome P450; Region: p450; cl12078 713604003581 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 713604003582 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 713604003583 Dimer interface [polypeptide binding]; other site 713604003584 anticodon binding site; other site 713604003585 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604003586 motif 1; other site 713604003587 dimer interface [polypeptide binding]; other site 713604003588 active site 713604003589 motif 2; other site 713604003590 motif 3; other site 713604003591 short chain dehydrogenase; Provisional; Region: PRK07454 713604003592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604003593 NAD(P) binding site [chemical binding]; other site 713604003594 active site 713604003595 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604003596 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604003597 haloalkane dehalogenase; Provisional; Region: PRK03592 713604003598 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604003599 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604003600 sugar binding site [chemical binding]; other site 713604003601 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604003602 Interdomain contacts; other site 713604003603 Cytokine receptor motif; other site 713604003604 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604003605 Interdomain contacts; other site 713604003606 Cytokine receptor motif; other site 713604003607 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604003608 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604003609 Uncharacterized conserved protein [Function unknown]; Region: COG0393 713604003610 Uncharacterized conserved protein [Function unknown]; Region: COG0393 713604003611 Uncharacterized conserved protein [Function unknown]; Region: COG0393 713604003612 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604003613 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 713604003614 substrate binding site [chemical binding]; other site 713604003615 ATP binding site [chemical binding]; other site 713604003616 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 713604003617 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 713604003618 NAD binding site [chemical binding]; other site 713604003619 sugar binding site [chemical binding]; other site 713604003620 divalent metal binding site [ion binding]; other site 713604003621 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604003622 dimer interface [polypeptide binding]; other site 713604003623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604003624 NAD(P) binding site [chemical binding]; other site 713604003625 active site 713604003626 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 713604003627 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604003628 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 713604003629 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 713604003630 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 713604003631 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 713604003632 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 713604003633 NAD(P) binding site [chemical binding]; other site 713604003634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003635 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604003636 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604003637 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604003638 TIGR03086 family protein; Region: TIGR03086 713604003639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003641 Domain of unknown function DUF11; Region: DUF11; cl17728 713604003642 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604003643 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003645 DNA binding residues [nucleotide binding] 713604003646 dimerization interface [polypeptide binding]; other site 713604003647 Rhomboid family; Region: Rhomboid; pfam01694 713604003648 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 713604003649 dihydropteroate synthase; Region: DHPS; TIGR01496 713604003650 substrate binding pocket [chemical binding]; other site 713604003651 dimer interface [polypeptide binding]; other site 713604003652 inhibitor binding site; inhibition site 713604003653 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604003654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003655 Walker A/P-loop; other site 713604003656 ATP binding site [chemical binding]; other site 713604003657 Q-loop/lid; other site 713604003658 ABC transporter signature motif; other site 713604003659 Walker B; other site 713604003660 D-loop; other site 713604003661 H-loop/switch region; other site 713604003662 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 713604003663 PGAP1-like protein; Region: PGAP1; pfam07819 713604003664 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003665 CHAT domain; Region: CHAT; cl17868 713604003666 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 713604003667 active site 713604003668 catalytic residues [active] 713604003669 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604003670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604003671 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 713604003672 substrate binding pocket [chemical binding]; other site 713604003673 catalytic residues [active] 713604003674 EamA-like transporter family; Region: EamA; pfam00892 713604003675 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 713604003676 EamA-like transporter family; Region: EamA; pfam00892 713604003677 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604003678 MarR family; Region: MarR_2; cl17246 713604003679 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604003680 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 713604003681 active site 713604003682 phosphorylation site [posttranslational modification] 713604003683 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 713604003684 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 713604003685 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 713604003686 active pocket/dimerization site; other site 713604003687 active site 713604003688 phosphorylation site [posttranslational modification] 713604003689 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 713604003690 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604003691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604003692 DNA-binding site [nucleotide binding]; DNA binding site 713604003693 UTRA domain; Region: UTRA; pfam07702 713604003694 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604003695 DNA binding site [nucleotide binding] 713604003696 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604003697 NB-ARC domain; Region: NB-ARC; pfam00931 713604003698 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604003700 binding surface 713604003701 TPR motif; other site 713604003702 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003703 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003704 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604003705 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604003706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604003707 putative substrate translocation pore; other site 713604003708 NMT1-like family; Region: NMT1_2; pfam13379 713604003709 NMT1/THI5 like; Region: NMT1; pfam09084 713604003710 membrane-bound complex binding site; other site 713604003711 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604003712 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 713604003713 Walker A/P-loop; other site 713604003714 ATP binding site [chemical binding]; other site 713604003715 Q-loop/lid; other site 713604003716 ABC transporter signature motif; other site 713604003717 Walker B; other site 713604003718 D-loop; other site 713604003719 H-loop/switch region; other site 713604003720 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 713604003721 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 713604003722 Walker A/P-loop; other site 713604003723 ATP binding site [chemical binding]; other site 713604003724 Q-loop/lid; other site 713604003725 ABC transporter signature motif; other site 713604003726 Walker B; other site 713604003727 D-loop; other site 713604003728 H-loop/switch region; other site 713604003729 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 713604003730 TM-ABC transporter signature motif; other site 713604003731 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 713604003732 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 713604003733 TM-ABC transporter signature motif; other site 713604003734 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604003735 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 713604003736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003738 NACHT domain; Region: NACHT; pfam05729 713604003739 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604003741 active site 713604003742 phosphorylation site [posttranslational modification] 713604003743 intermolecular recognition site; other site 713604003744 dimerization interface [polypeptide binding]; other site 713604003745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003746 DNA binding residues [nucleotide binding] 713604003747 Putative sensor; Region: Sensor; pfam13796 713604003748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604003749 Histidine kinase; Region: HisKA_3; pfam07730 713604003750 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604003751 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604003752 Walker A/P-loop; other site 713604003753 ATP binding site [chemical binding]; other site 713604003754 Q-loop/lid; other site 713604003755 ABC transporter signature motif; other site 713604003756 Walker B; other site 713604003757 D-loop; other site 713604003758 H-loop/switch region; other site 713604003759 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 713604003760 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 713604003761 FtsX-like permease family; Region: FtsX; pfam02687 713604003762 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 713604003763 Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs; Region: CE4_SlAXE_like; cd10953 713604003764 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604003765 NodB motif; other site 713604003766 active site 713604003767 catalytic site [active] 713604003768 Zn binding site [ion binding]; other site 713604003769 dimer interface [polypeptide binding]; other site 713604003770 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604003771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604003772 Walker A/P-loop; other site 713604003773 ATP binding site [chemical binding]; other site 713604003774 Q-loop/lid; other site 713604003775 ABC transporter signature motif; other site 713604003776 Walker B; other site 713604003777 D-loop; other site 713604003778 H-loop/switch region; other site 713604003779 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604003780 Uncharacterized conserved protein [Function unknown]; Region: COG3391 713604003781 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604003782 Phosphoesterase family; Region: Phosphoesterase; pfam04185 713604003783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604003784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604003785 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604003786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604003787 putative substrate translocation pore; other site 713604003788 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 713604003789 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604003790 NAD binding site [chemical binding]; other site 713604003791 catalytic residues [active] 713604003792 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 713604003793 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604003794 Glucose dehydrogenase; Region: glucose_DH; cd08230 713604003795 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604003796 NADP binding site [chemical binding]; other site 713604003797 catalytic Zn binding site [ion binding]; other site 713604003798 structural Zn binding site [ion binding]; other site 713604003799 dimer interface [polypeptide binding]; other site 713604003800 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604003801 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604003802 Q-X-W motif; other site 713604003803 putative sugar binding sites [chemical binding]; other site 713604003804 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604003805 Chitin binding domain; Region: Chitin_bind_3; pfam03067 713604003806 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604003807 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604003808 Protein of unknown function DUF72; Region: DUF72; pfam01904 713604003809 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 713604003810 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 713604003811 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 713604003812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 713604003813 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604003814 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604003815 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 713604003816 Zn binding site [ion binding]; other site 713604003817 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604003818 MarR family; Region: MarR_2; cl17246 713604003819 RHS Repeat; Region: RHS_repeat; cl11982 713604003820 RHS Repeat; Region: RHS_repeat; pfam05593 713604003821 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604003822 RHS Repeat; Region: RHS_repeat; cl11982 713604003823 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604003824 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604003825 RHS Repeat; Region: RHS_repeat; cl11982 713604003826 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604003827 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604003828 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 713604003829 HI0933-like protein; Region: HI0933_like; pfam03486 713604003830 DinB superfamily; Region: DinB_2; pfam12867 713604003831 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 713604003832 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604003833 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604003834 putative NAD(P) binding site [chemical binding]; other site 713604003835 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604003836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003837 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604003838 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604003839 putative NAD(P) binding site [chemical binding]; other site 713604003840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604003841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604003842 ATP binding site [chemical binding]; other site 713604003843 Mg2+ binding site [ion binding]; other site 713604003844 G-X-G motif; other site 713604003845 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 713604003846 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604003847 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604003848 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604003849 G1 box; other site 713604003850 GTP/Mg2+ binding site [chemical binding]; other site 713604003851 G2 box; other site 713604003852 Switch I region; other site 713604003853 G3 box; other site 713604003854 Switch II region; other site 713604003855 G5 box; other site 713604003856 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604003857 short chain dehydrogenase; Provisional; Region: PRK06523 713604003858 classical (c) SDRs; Region: SDR_c; cd05233 713604003859 NAD(P) binding site [chemical binding]; other site 713604003860 active site 713604003861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604003862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604003863 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 713604003864 dimerization interface [polypeptide binding]; other site 713604003865 short chain dehydrogenase; Provisional; Region: PRK06500 713604003866 classical (c) SDRs; Region: SDR_c; cd05233 713604003867 NAD(P) binding site [chemical binding]; other site 713604003868 active site 713604003869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003871 hypothetical protein; Provisional; Region: PRK06184 713604003872 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604003873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604003876 Transposase; Region: HTH_Tnp_1; cl17663 713604003877 putative transposase OrfB; Reviewed; Region: PHA02517 713604003878 HTH-like domain; Region: HTH_21; pfam13276 713604003879 Integrase core domain; Region: rve; pfam00665 713604003880 Integrase core domain; Region: rve_3; pfam13683 713604003881 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 713604003882 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604003883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604003884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604003885 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604003886 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604003887 active site 713604003888 catalytic tetrad [active] 713604003889 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604003890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604003891 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604003892 DNA binding residues [nucleotide binding] 713604003893 putative transposase OrfB; Reviewed; Region: PHA02517 713604003894 HTH-like domain; Region: HTH_21; pfam13276 713604003895 Integrase core domain; Region: rve; pfam00665 713604003896 Integrase core domain; Region: rve_3; pfam13683 713604003897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604003898 Transposase; Region: HTH_Tnp_1; cl17663 713604003899 AAA ATPase domain; Region: AAA_16; pfam13191 713604003900 NB-ARC domain; Region: NB-ARC; pfam00931 713604003901 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604003903 binding surface 713604003904 TPR motif; other site 713604003905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604003906 binding surface 713604003907 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003908 TPR motif; other site 713604003909 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604003910 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604003911 MarR family; Region: MarR_2; pfam12802 713604003912 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 713604003913 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 713604003914 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604003915 MarR family; Region: MarR; pfam01047 713604003916 DoxX-like family; Region: DoxX_2; pfam13564 713604003917 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604003918 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604003919 putative NAD(P) binding site [chemical binding]; other site 713604003920 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 713604003921 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 713604003922 putative active site [active] 713604003923 metal binding site [ion binding]; metal-binding site 713604003924 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 713604003925 active site 713604003926 catalytic residues [active] 713604003927 metal binding site [ion binding]; metal-binding site 713604003928 AMP-binding domain protein; Validated; Region: PRK08315 713604003929 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604003930 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 713604003931 acyl-activating enzyme (AAE) consensus motif; other site 713604003932 putative AMP binding site [chemical binding]; other site 713604003933 putative active site [active] 713604003934 putative CoA binding site [chemical binding]; other site 713604003935 Predicted acyl esterases [General function prediction only]; Region: COG2936 713604003936 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604003937 GAF domain; Region: GAF_2; pfam13185 713604003938 GAF domain; Region: GAF; cl17456 713604003939 Histidine kinase; Region: HisKA_3; pfam07730 713604003940 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604003941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604003942 ATP binding site [chemical binding]; other site 713604003943 Mg2+ binding site [ion binding]; other site 713604003944 G-X-G motif; other site 713604003945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604003946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 713604003947 active site 713604003948 phosphorylation site [posttranslational modification] 713604003949 intermolecular recognition site; other site 713604003950 dimerization interface [polypeptide binding]; other site 713604003951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604003952 DNA binding residues [nucleotide binding] 713604003953 dimerization interface [polypeptide binding]; other site 713604003954 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 713604003955 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604003956 active site 713604003957 Int/Topo IB signature motif; other site 713604003958 DNA binding site [nucleotide binding] 713604003959 Helix-turn-helix domain; Region: HTH_17; cl17695 713604003960 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604003961 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604003962 putative sugar binding sites [chemical binding]; other site 713604003963 Q-X-W motif; other site 713604003964 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 713604003965 ribonuclease Z; Reviewed; Region: PRK00055 713604003966 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 713604003967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604003968 active site 713604003969 phosphorylation site [posttranslational modification] 713604003970 intermolecular recognition site; other site 713604003971 dimerization interface [polypeptide binding]; other site 713604003972 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 713604003973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604003974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604003975 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604003976 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604003977 ligand binding site [chemical binding]; other site 713604003978 flexible hinge region; other site 713604003979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604003980 ATP binding site [chemical binding]; other site 713604003981 Mg2+ binding site [ion binding]; other site 713604003982 G-X-G motif; other site 713604003983 Carboxylesterase family; Region: COesterase; pfam00135 713604003984 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604003985 substrate binding pocket [chemical binding]; other site 713604003986 catalytic triad [active] 713604003987 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 713604003988 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 713604003989 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604003990 von Willebrand factor type A domain; Region: VWA_2; pfam13519 713604003991 metal ion-dependent adhesion site (MIDAS); other site 713604003992 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 713604003993 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 713604003994 Transposase; Region: DEDD_Tnp_IS110; pfam01548 713604003995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 713604003996 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 713604003997 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 713604003998 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 713604003999 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 713604004000 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 713604004001 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 713604004002 Moco binding site; other site 713604004003 metal coordination site [ion binding]; other site 713604004004 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 713604004005 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 713604004006 FAD binding pocket [chemical binding]; other site 713604004007 FAD binding motif [chemical binding]; other site 713604004008 phosphate binding motif [ion binding]; other site 713604004009 beta-alpha-beta structure motif; other site 713604004010 NAD binding pocket [chemical binding]; other site 713604004011 Right handed beta helix region; Region: Beta_helix; pfam13229 713604004012 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604004013 Interdomain contacts; other site 713604004014 Cytokine receptor motif; other site 713604004015 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604004016 Interdomain contacts; other site 713604004017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604004018 DNA binding residues [nucleotide binding] 713604004019 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604004020 nucleotide binding site [chemical binding]; other site 713604004021 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604004022 Dynamin family; Region: Dynamin_N; pfam00350 713604004023 G1 box; other site 713604004024 GTP/Mg2+ binding site [chemical binding]; other site 713604004025 G2 box; other site 713604004026 Switch I region; other site 713604004027 G3 box; other site 713604004028 Switch II region; other site 713604004029 G4 box; other site 713604004030 G5 box; other site 713604004031 AAA domain; Region: AAA_28; pfam13521 713604004032 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 713604004033 homotrimer interaction site [polypeptide binding]; other site 713604004034 putative active site [active] 713604004035 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604004036 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604004037 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604004038 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604004039 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604004040 acyl-activating enzyme (AAE) consensus motif; other site 713604004041 acyl-activating enzyme (AAE) consensus motif; other site 713604004042 putative AMP binding site [chemical binding]; other site 713604004043 putative active site [active] 713604004044 putative CoA binding site [chemical binding]; other site 713604004045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004047 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604004048 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604004049 catalytic residue [active] 713604004050 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604004051 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 713604004052 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604004053 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604004054 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604004055 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604004056 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604004057 substrate binding pocket [chemical binding]; other site 713604004058 membrane-bound complex binding site; other site 713604004059 hinge residues; other site 713604004060 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 713604004061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604004062 dimer interface [polypeptide binding]; other site 713604004063 conserved gate region; other site 713604004064 putative PBP binding loops; other site 713604004065 ABC-ATPase subunit interface; other site 713604004066 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 713604004067 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 713604004068 Walker A/P-loop; other site 713604004069 ATP binding site [chemical binding]; other site 713604004070 Q-loop/lid; other site 713604004071 ABC transporter signature motif; other site 713604004072 Walker B; other site 713604004073 D-loop; other site 713604004074 H-loop/switch region; other site 713604004075 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604004076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604004077 catalytic residue [active] 713604004078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 713604004079 YheO-like PAS domain; Region: PAS_6; pfam08348 713604004080 HTH domain; Region: HTH_22; pfam13309 713604004081 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604004082 active site 713604004083 TDP-binding site; other site 713604004084 glycosyltransferase, MGT family; Region: MGT; TIGR01426 713604004085 acceptor substrate-binding pocket; other site 713604004086 homodimer interface [polypeptide binding]; other site 713604004087 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604004088 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604004089 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604004090 Walker A/P-loop; other site 713604004091 ATP binding site [chemical binding]; other site 713604004092 Q-loop/lid; other site 713604004093 ABC transporter signature motif; other site 713604004094 Walker B; other site 713604004095 D-loop; other site 713604004096 H-loop/switch region; other site 713604004097 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604004098 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 713604004099 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604004100 DNA polymerase IV; Provisional; Region: PRK03348 713604004101 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 713604004102 active site 713604004103 DNA binding site [nucleotide binding] 713604004104 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 713604004105 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604004106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004107 DNA-binding site [nucleotide binding]; DNA binding site 713604004108 FCD domain; Region: FCD; pfam07729 713604004109 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604004110 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604004111 TM-ABC transporter signature motif; other site 713604004112 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 713604004113 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604004114 Walker A/P-loop; other site 713604004115 ATP binding site [chemical binding]; other site 713604004116 Q-loop/lid; other site 713604004117 ABC transporter signature motif; other site 713604004118 Walker B; other site 713604004119 D-loop; other site 713604004120 H-loop/switch region; other site 713604004121 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604004122 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 713604004123 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604004124 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 713604004125 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 713604004126 putative active site [active] 713604004127 putative metal binding site [ion binding]; other site 713604004128 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 713604004129 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 713604004130 substrate binding pocket [chemical binding]; other site 713604004131 chain length determination region; other site 713604004132 substrate-Mg2+ binding site; other site 713604004133 catalytic residues [active] 713604004134 aspartate-rich region 1; other site 713604004135 active site lid residues [active] 713604004136 aspartate-rich region 2; other site 713604004137 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604004138 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604004139 ligand binding site [chemical binding]; other site 713604004140 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604004141 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604004142 ligand binding site [chemical binding]; other site 713604004143 flexible hinge region; other site 713604004144 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 713604004145 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 713604004146 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604004147 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 713604004148 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 713604004149 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 713604004150 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604004151 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604004153 binding surface 713604004154 TPR motif; other site 713604004155 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004156 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604004158 binding surface 713604004159 TPR motif; other site 713604004160 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004161 PhoD-like phosphatase; Region: PhoD; pfam09423 713604004162 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 713604004163 putative active site [active] 713604004164 putative metal binding site [ion binding]; other site 713604004165 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 713604004166 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 713604004167 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 713604004168 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 713604004169 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604004170 alpha-glucosidase; Provisional; Region: PRK10137 713604004171 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 713604004172 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604004173 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604004174 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 713604004175 peptidase domain interface [polypeptide binding]; other site 713604004176 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604004177 active site 713604004178 catalytic triad [active] 713604004179 calcium binding site [ion binding]; other site 713604004180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604004181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604004182 ATP binding site [chemical binding]; other site 713604004183 Mg2+ binding site [ion binding]; other site 713604004184 G-X-G motif; other site 713604004185 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604004186 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 713604004187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604004188 NAD(P) binding site [chemical binding]; other site 713604004189 active site 713604004190 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 713604004191 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 713604004192 NMT1-like family; Region: NMT1_2; pfam13379 713604004193 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 713604004194 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604004195 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604004196 Walker A/P-loop; other site 713604004197 ATP binding site [chemical binding]; other site 713604004198 Q-loop/lid; other site 713604004199 ABC transporter signature motif; other site 713604004200 Walker B; other site 713604004201 D-loop; other site 713604004202 H-loop/switch region; other site 713604004203 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604004204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604004205 dimer interface [polypeptide binding]; other site 713604004206 conserved gate region; other site 713604004207 putative PBP binding loops; other site 713604004208 ABC-ATPase subunit interface; other site 713604004209 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 713604004210 Strictosidine synthase; Region: Str_synth; pfam03088 713604004211 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 713604004212 DEAD-like helicases superfamily; Region: DEXDc; smart00487 713604004213 ATP binding site [chemical binding]; other site 713604004214 Mg++ binding site [ion binding]; other site 713604004215 motif III; other site 713604004216 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604004217 nucleotide binding region [chemical binding]; other site 713604004218 ATP-binding site [chemical binding]; other site 713604004219 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604004220 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604004221 active site 713604004222 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604004223 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 713604004224 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 713604004225 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 713604004226 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 713604004227 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 713604004228 RNA binding site [nucleotide binding]; other site 713604004229 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 713604004230 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 713604004231 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 713604004232 putative active site [active] 713604004233 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 713604004234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604004235 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604004236 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604004237 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 713604004238 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604004239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604004240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004242 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604004243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004245 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604004246 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 713604004247 acyl-activating enzyme (AAE) consensus motif; other site 713604004248 AMP binding site [chemical binding]; other site 713604004249 active site 713604004250 CoA binding site [chemical binding]; other site 713604004251 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604004252 CoenzymeA binding site [chemical binding]; other site 713604004253 subunit interaction site [polypeptide binding]; other site 713604004254 PHB binding site; other site 713604004255 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 713604004256 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 713604004257 substrate binding site [chemical binding]; other site 713604004258 dimer interface [polypeptide binding]; other site 713604004259 NADP binding site [chemical binding]; other site 713604004260 catalytic residues [active] 713604004261 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604004262 active site 2 [active] 713604004263 active site 1 [active] 713604004264 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 713604004265 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 713604004266 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 713604004267 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 713604004268 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 713604004269 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 713604004270 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 713604004271 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 713604004272 FAD binding pocket [chemical binding]; other site 713604004273 FAD binding motif [chemical binding]; other site 713604004274 phosphate binding motif [ion binding]; other site 713604004275 beta-alpha-beta structure motif; other site 713604004276 NAD(p) ribose binding residues [chemical binding]; other site 713604004277 NAD binding pocket [chemical binding]; other site 713604004278 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 713604004279 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604004280 catalytic loop [active] 713604004281 iron binding site [ion binding]; other site 713604004282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604004283 non-specific DNA binding site [nucleotide binding]; other site 713604004284 salt bridge; other site 713604004285 sequence-specific DNA binding site [nucleotide binding]; other site 713604004286 cyclase homology domain; Region: CHD; cd07302 713604004287 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 713604004288 nucleotidyl binding site; other site 713604004289 metal binding site [ion binding]; metal-binding site 713604004290 dimer interface [polypeptide binding]; other site 713604004291 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604004292 Ligand Binding Site [chemical binding]; other site 713604004293 DivIVA protein; Region: DivIVA; pfam05103 713604004294 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604004295 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 713604004296 NAD(P) binding site [chemical binding]; other site 713604004297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004299 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 713604004300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604004301 dimer interface [polypeptide binding]; other site 713604004302 substrate binding site [chemical binding]; other site 713604004303 metal binding site [ion binding]; metal-binding site 713604004304 putative acyltransferase; Provisional; Region: PRK05790 713604004305 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604004306 dimer interface [polypeptide binding]; other site 713604004307 active site 713604004308 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 713604004309 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 713604004310 Walker A; other site 713604004311 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 713604004312 active site 713604004313 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604004314 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004315 DNA-binding site [nucleotide binding]; DNA binding site 713604004316 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604004317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004318 homodimer interface [polypeptide binding]; other site 713604004319 catalytic residue [active] 713604004320 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604004321 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604004322 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 713604004323 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 713604004324 tetramer interface [polypeptide binding]; other site 713604004325 active site 713604004326 Mg2+/Mn2+ binding site [ion binding]; other site 713604004327 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 713604004328 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 713604004329 Na binding site [ion binding]; other site 713604004330 Protein of unknown function, DUF485; Region: DUF485; pfam04341 713604004331 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604004332 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604004333 Na binding site [ion binding]; other site 713604004334 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 713604004335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604004336 active site 713604004337 phosphorylation site [posttranslational modification] 713604004338 intermolecular recognition site; other site 713604004339 dimerization interface [polypeptide binding]; other site 713604004340 LytTr DNA-binding domain; Region: LytTR; smart00850 713604004341 Histidine kinase; Region: His_kinase; pfam06580 713604004342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604004343 ATP binding site [chemical binding]; other site 713604004344 Mg2+ binding site [ion binding]; other site 713604004345 G-X-G motif; other site 713604004346 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 713604004347 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 713604004348 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 713604004349 putative ligand binding site [chemical binding]; other site 713604004350 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604004351 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604004352 TM-ABC transporter signature motif; other site 713604004353 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604004354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604004355 Walker A/P-loop; other site 713604004356 ATP binding site [chemical binding]; other site 713604004357 Q-loop/lid; other site 713604004358 ABC transporter signature motif; other site 713604004359 Walker B; other site 713604004360 D-loop; other site 713604004361 H-loop/switch region; other site 713604004362 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 713604004363 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 713604004364 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604004365 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604004366 DNA binding site [nucleotide binding] 713604004367 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604004368 dimerization interface [polypeptide binding]; other site 713604004369 ligand binding site [chemical binding]; other site 713604004370 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604004371 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604004372 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604004373 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604004374 integral membrane protein; Region: integ_memb_HG; TIGR03954 713604004375 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604004376 MarR family; Region: MarR; pfam01047 713604004377 Domain of unknown function DUF77; Region: DUF77; pfam01910 713604004378 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 713604004379 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 713604004380 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604004381 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604004382 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 713604004383 putative homodimer interface [polypeptide binding]; other site 713604004384 putative active site pocket [active] 713604004385 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 713604004386 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604004387 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604004388 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 713604004389 active site residue [active] 713604004390 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 713604004391 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604004392 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604004393 Walker A/P-loop; other site 713604004394 ATP binding site [chemical binding]; other site 713604004395 Q-loop/lid; other site 713604004396 ABC transporter signature motif; other site 713604004397 Walker B; other site 713604004398 D-loop; other site 713604004399 H-loop/switch region; other site 713604004400 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 713604004401 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604004402 substrate binding site [chemical binding]; other site 713604004403 oxyanion hole (OAH) forming residues; other site 713604004404 trimer interface [polypeptide binding]; other site 713604004405 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604004406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604004407 S-adenosylmethionine binding site [chemical binding]; other site 713604004408 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 713604004409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 713604004410 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604004411 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604004412 LysR substrate binding domain; Region: LysR_substrate; pfam03466 713604004413 dimerization interface [polypeptide binding]; other site 713604004414 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 713604004415 active site 713604004416 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 713604004417 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604004418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004419 DNA-binding site [nucleotide binding]; DNA binding site 713604004420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004422 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604004423 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604004424 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604004425 hypothetical protein; Provisional; Region: PRK08244 713604004426 hypothetical protein; Provisional; Region: PRK07236 713604004427 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604004428 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604004429 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604004430 MarR family; Region: MarR_2; pfam12802 713604004431 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604004432 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604004433 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604004434 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604004435 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604004436 active site 713604004437 catalytic tetrad [active] 713604004438 hypothetical protein; Provisional; Region: PRK06834 713604004439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604004440 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604004441 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604004442 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604004443 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 713604004444 active site 713604004445 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 713604004446 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 713604004447 trimer interface [polypeptide binding]; other site 713604004448 active site 713604004449 substrate binding site [chemical binding]; other site 713604004450 CoA binding site [chemical binding]; other site 713604004451 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 713604004452 threonine dehydratase; Validated; Region: PRK08639 713604004453 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 713604004454 tetramer interface [polypeptide binding]; other site 713604004455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004456 catalytic residue [active] 713604004457 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 713604004458 putative Ile/Val binding site [chemical binding]; other site 713604004459 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604004460 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604004461 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604004462 DNA binding residues [nucleotide binding] 713604004463 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604004464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604004465 non-specific DNA binding site [nucleotide binding]; other site 713604004466 salt bridge; other site 713604004467 sequence-specific DNA binding site [nucleotide binding]; other site 713604004468 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 713604004469 Domain of unknown function (DUF955); Region: DUF955; pfam06114 713604004470 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 713604004471 isocitrate lyase; Provisional; Region: PRK15063 713604004472 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 713604004473 tetramer interface [polypeptide binding]; other site 713604004474 active site 713604004475 Mg2+/Mn2+ binding site [ion binding]; other site 713604004476 malate synthase A; Region: malate_syn_A; TIGR01344 713604004477 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 713604004478 active site 713604004479 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 713604004480 PA/protease or protease-like domain interface [polypeptide binding]; other site 713604004481 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 713604004482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004484 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 713604004485 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604004486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604004487 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604004488 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604004489 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604004490 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604004491 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 713604004492 catalytic residues [active] 713604004493 dimer interface [polypeptide binding]; other site 713604004494 Uncharacterized conserved protein [Function unknown]; Region: COG1543 713604004495 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 713604004496 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 713604004497 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604004498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604004499 S-adenosylmethionine binding site [chemical binding]; other site 713604004500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 713604004501 EDD domain protein, DegV family; Region: DegV; TIGR00762 713604004502 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 713604004503 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 713604004504 Ligand binding site [chemical binding]; other site 713604004505 Electron transfer flavoprotein domain; Region: ETF; pfam01012 713604004506 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 713604004507 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 713604004508 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 713604004509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 713604004510 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604004511 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604004512 putative acyl-acceptor binding pocket; other site 713604004513 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604004514 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604004515 putative NAD(P) binding site [chemical binding]; other site 713604004516 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604004517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604004518 DNA binding residues [nucleotide binding] 713604004519 dimerization interface [polypeptide binding]; other site 713604004520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604004521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604004522 putative substrate translocation pore; other site 713604004523 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 713604004524 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 713604004525 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604004526 catalytic residue [active] 713604004527 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 713604004528 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604004529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604004530 Coenzyme A binding pocket [chemical binding]; other site 713604004531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604004532 Coenzyme A binding pocket [chemical binding]; other site 713604004533 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 713604004534 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 713604004535 Scramblase; Region: Scramblase; pfam03803 713604004536 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 713604004537 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 713604004538 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 713604004539 nucleotide binding pocket [chemical binding]; other site 713604004540 K-X-D-G motif; other site 713604004541 catalytic site [active] 713604004542 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 713604004543 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 713604004544 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 713604004545 Dimer interface [polypeptide binding]; other site 713604004546 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604004547 Coenzyme A binding pocket [chemical binding]; other site 713604004548 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 713604004549 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 713604004550 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 713604004551 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 713604004552 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 713604004553 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 713604004554 GatB domain; Region: GatB_Yqey; smart00845 713604004555 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604004556 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604004557 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604004558 Methane oxygenase PmoA; Region: PmoA; pfam14100 713604004559 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604004560 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604004561 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 713604004562 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 713604004563 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604004564 putative ligand binding site [chemical binding]; other site 713604004565 putative NAD binding site [chemical binding]; other site 713604004566 catalytic site [active] 713604004567 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 713604004568 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 713604004569 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 713604004570 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604004571 PYR/PP interface [polypeptide binding]; other site 713604004572 dimer interface [polypeptide binding]; other site 713604004573 TPP binding site [chemical binding]; other site 713604004574 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 713604004575 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 713604004576 TPP-binding site [chemical binding]; other site 713604004577 dimer interface [polypeptide binding]; other site 713604004578 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 713604004579 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 713604004580 putative valine binding site [chemical binding]; other site 713604004581 dimer interface [polypeptide binding]; other site 713604004582 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 713604004583 ketol-acid reductoisomerase; Provisional; Region: PRK05479 713604004584 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 713604004585 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 713604004586 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604004587 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604004588 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604004589 replicative DNA helicase; Provisional; Region: PRK05973 713604004590 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 713604004591 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 713604004592 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 713604004593 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 713604004594 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604004595 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604004596 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604004597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004599 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 713604004600 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 713604004601 ligand binding site [chemical binding]; other site 713604004602 NAD binding site [chemical binding]; other site 713604004603 dimerization interface [polypeptide binding]; other site 713604004604 catalytic site [active] 713604004605 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 713604004606 putative L-serine binding site [chemical binding]; other site 713604004607 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 713604004608 putative active site [active] 713604004609 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 713604004610 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 713604004611 tartrate dehydrogenase; Region: TTC; TIGR02089 713604004612 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 713604004613 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 713604004614 active site 713604004615 catalytic residues [active] 713604004616 metal binding site [ion binding]; metal-binding site 713604004617 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 713604004618 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 713604004619 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604004620 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604004621 hypothetical protein; Provisional; Region: PRK06185 713604004622 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604004623 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 713604004624 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604004625 motif II; other site 713604004626 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 713604004627 IHF - DNA interface [nucleotide binding]; other site 713604004628 IHF dimer interface [polypeptide binding]; other site 713604004629 cyclase homology domain; Region: CHD; cd07302 713604004630 NB-ARC domain; Region: NB-ARC; pfam00931 713604004631 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004632 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604004634 binding surface 713604004635 TPR motif; other site 713604004636 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604004638 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604004639 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604004640 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 713604004641 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 713604004642 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004643 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004644 Lsr2; Region: Lsr2; pfam11774 713604004645 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 713604004646 IHF - DNA interface [nucleotide binding]; other site 713604004647 IHF dimer interface [polypeptide binding]; other site 713604004648 HerA helicase [Replication, recombination, and repair]; Region: COG0433 713604004649 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 713604004650 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 713604004651 active site 713604004652 metal binding site [ion binding]; metal-binding site 713604004653 DNA binding site [nucleotide binding] 713604004654 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 713604004655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604004656 ABC transporter signature motif; other site 713604004657 Walker B; other site 713604004658 D-loop; other site 713604004659 H-loop/switch region; other site 713604004660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 713604004661 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 713604004662 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604004663 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604004664 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604004665 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604004666 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604004667 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604004668 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 713604004669 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 713604004670 substrate binding site [chemical binding]; other site 713604004671 ligand binding site [chemical binding]; other site 713604004672 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 713604004673 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 713604004674 substrate binding site [chemical binding]; other site 713604004675 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 713604004676 IHF - DNA interface [nucleotide binding]; other site 713604004677 IHF dimer interface [polypeptide binding]; other site 713604004678 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 713604004679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 713604004680 NB-ARC domain; Region: NB-ARC; pfam00931 713604004681 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604004682 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 713604004683 active site 713604004684 Ap6A binding site [chemical binding]; other site 713604004685 nudix motif; other site 713604004686 metal binding site [ion binding]; metal-binding site 713604004687 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604004688 catalytic core [active] 713604004689 polyphosphate kinase; Provisional; Region: PRK05443 713604004690 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 713604004691 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 713604004692 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 713604004693 putative domain interface [polypeptide binding]; other site 713604004694 putative active site [active] 713604004695 catalytic site [active] 713604004696 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 713604004697 putative domain interface [polypeptide binding]; other site 713604004698 putative active site [active] 713604004699 catalytic site [active] 713604004700 Guanylyl transferase CofC like; Region: CofC; cl17472 713604004701 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604004702 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604004703 putative acyl-acceptor binding pocket; other site 713604004704 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 713604004705 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 713604004706 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 713604004707 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 713604004708 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 713604004709 active site 713604004710 homotetramer interface [polypeptide binding]; other site 713604004711 homodimer interface [polypeptide binding]; other site 713604004712 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604004713 active site 713604004714 ApbE family; Region: ApbE; pfam02424 713604004715 FMN-binding domain; Region: FMN_bind; cl01081 713604004716 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 713604004717 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 713604004718 FAD binding pocket [chemical binding]; other site 713604004719 FAD binding motif [chemical binding]; other site 713604004720 phosphate binding motif [ion binding]; other site 713604004721 beta-alpha-beta structure motif; other site 713604004722 NAD binding pocket [chemical binding]; other site 713604004723 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604004724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604004725 active site 713604004726 phosphorylation site [posttranslational modification] 713604004727 intermolecular recognition site; other site 713604004728 dimerization interface [polypeptide binding]; other site 713604004729 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604004730 DNA binding site [nucleotide binding] 713604004731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604004732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604004733 dimer interface [polypeptide binding]; other site 713604004734 phosphorylation site [posttranslational modification] 713604004735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604004736 ATP binding site [chemical binding]; other site 713604004737 Mg2+ binding site [ion binding]; other site 713604004738 G-X-G motif; other site 713604004739 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 713604004740 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604004741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004742 DNA-binding site [nucleotide binding]; DNA binding site 713604004743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604004744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004745 homodimer interface [polypeptide binding]; other site 713604004746 catalytic residue [active] 713604004747 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 713604004748 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 713604004749 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604004750 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 713604004751 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604004752 AsnC family; Region: AsnC_trans_reg; pfam01037 713604004753 thiamine monophosphate kinase; Provisional; Region: PRK05731 713604004754 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 713604004755 ATP binding site [chemical binding]; other site 713604004756 dimerization interface [polypeptide binding]; other site 713604004757 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 713604004758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604004759 Coenzyme A binding pocket [chemical binding]; other site 713604004760 alpha-galactosidase; Region: PLN02808; cl17638 713604004761 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 713604004762 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 713604004763 trimer interface [polypeptide binding]; other site 713604004764 putative metal binding site [ion binding]; other site 713604004765 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 713604004766 ligand binding site [chemical binding]; other site 713604004767 active site 713604004768 UGI interface [polypeptide binding]; other site 713604004769 catalytic site [active] 713604004770 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604004771 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 713604004772 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 713604004773 DAK2 domain; Region: Dak2; pfam02734 713604004774 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 713604004775 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 713604004776 generic binding surface II; other site 713604004777 ssDNA binding site; other site 713604004778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604004779 ATP binding site [chemical binding]; other site 713604004780 putative Mg++ binding site [ion binding]; other site 713604004781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604004782 nucleotide binding region [chemical binding]; other site 713604004783 ATP-binding site [chemical binding]; other site 713604004784 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 713604004785 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604004786 Coenzyme A binding pocket [chemical binding]; other site 713604004787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604004788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604004789 Erythromycin esterase; Region: Erythro_esteras; pfam05139 713604004790 Caspase domain; Region: Peptidase_C14; pfam00656 713604004791 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 713604004792 calcium binding site 2 [ion binding]; other site 713604004793 active site 713604004794 catalytic triad [active] 713604004795 calcium binding site 1 [ion binding]; other site 713604004796 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 713604004797 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604004798 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 713604004799 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604004800 pyruvate carboxylase; Reviewed; Region: PRK12999 713604004801 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604004802 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604004803 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 713604004804 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 713604004805 active site 713604004806 catalytic residues [active] 713604004807 metal binding site [ion binding]; metal-binding site 713604004808 homodimer binding site [polypeptide binding]; other site 713604004809 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604004810 carboxyltransferase (CT) interaction site; other site 713604004811 biotinylation site [posttranslational modification]; other site 713604004812 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 713604004813 active site 713604004814 Mn binding site [ion binding]; other site 713604004815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004816 DNA-binding site [nucleotide binding]; DNA binding site 713604004817 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604004818 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604004819 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604004820 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604004821 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 713604004822 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604004823 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604004824 mce related protein; Region: MCE; pfam02470 713604004825 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604004826 mce related protein; Region: MCE; pfam02470 713604004827 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604004828 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604004829 mce related protein; Region: MCE; pfam02470 713604004830 mce related protein; Region: MCE; pfam02470 713604004831 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604004832 mce related protein; Region: MCE; pfam02470 713604004833 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604004834 mce related protein; Region: MCE; pfam02470 713604004835 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604004836 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604004837 Permease; Region: Permease; pfam02405 713604004838 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604004839 Permease; Region: Permease; pfam02405 713604004840 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 713604004841 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 713604004842 hypothetical protein; Provisional; Region: PRK08244 713604004843 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604004844 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604004845 non-specific DNA binding site [nucleotide binding]; other site 713604004846 salt bridge; other site 713604004847 sequence-specific DNA binding site [nucleotide binding]; other site 713604004848 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 713604004849 structural tetrad; other site 713604004850 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604004851 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 713604004852 structural tetrad; other site 713604004853 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604004854 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 713604004855 Family description; Region: UvrD_C_2; pfam13538 713604004856 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 713604004857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604004858 S-adenosylmethionine binding site [chemical binding]; other site 713604004859 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 713604004860 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 713604004861 active site 713604004862 (T/H)XGH motif; other site 713604004863 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 713604004864 active site 713604004865 barstar interaction site; other site 713604004866 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 713604004867 active site 713604004868 RNA polymerase factor sigma-70; Validated; Region: PRK09047 713604004869 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604004870 DNA binding residues [nucleotide binding] 713604004871 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 713604004872 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 713604004873 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 713604004874 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 713604004875 ribonuclease III; Reviewed; Region: rnc; PRK00102 713604004876 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 713604004877 dimerization interface [polypeptide binding]; other site 713604004878 active site 713604004879 metal binding site [ion binding]; metal-binding site 713604004880 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 713604004881 dsRNA binding site [nucleotide binding]; other site 713604004882 Right handed beta helix region; Region: Beta_helix; pfam13229 713604004883 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 713604004884 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 713604004885 DNA binding site [nucleotide binding] 713604004886 catalytic residue [active] 713604004887 H2TH interface [polypeptide binding]; other site 713604004888 putative catalytic residues [active] 713604004889 turnover-facilitating residue; other site 713604004890 intercalation triad [nucleotide binding]; other site 713604004891 8OG recognition residue [nucleotide binding]; other site 713604004892 putative reading head residues; other site 713604004893 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604004894 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 713604004895 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 713604004896 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604004897 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604004898 Predicted membrane protein [Function unknown]; Region: COG4709 713604004899 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604004900 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604004901 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 713604004902 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 713604004903 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604004904 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 713604004905 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 713604004906 catalytic triad [active] 713604004907 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604004908 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 713604004909 NAD(P) binding site [chemical binding]; other site 713604004910 catalytic residues [active] 713604004911 short chain dehydrogenase; Provisional; Region: PRK06057 713604004912 classical (c) SDRs; Region: SDR_c; cd05233 713604004913 NAD(P) binding site [chemical binding]; other site 713604004914 active site 713604004915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604004916 non-specific DNA binding site [nucleotide binding]; other site 713604004917 salt bridge; other site 713604004918 sequence-specific DNA binding site [nucleotide binding]; other site 713604004919 glycine dehydrogenase; Provisional; Region: PRK05367 713604004920 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 713604004921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004922 tetramer interface [polypeptide binding]; other site 713604004923 catalytic residue [active] 713604004924 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 713604004925 tetramer interface [polypeptide binding]; other site 713604004926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004927 catalytic residue [active] 713604004928 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 713604004929 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 713604004930 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 713604004931 lipoyl attachment site [posttranslational modification]; other site 713604004932 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 713604004933 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 713604004934 dimer interface [polypeptide binding]; other site 713604004935 active site 713604004936 glycine-pyridoxal phosphate binding site [chemical binding]; other site 713604004937 folate binding site [chemical binding]; other site 713604004938 lipoyl synthase; Provisional; Region: PRK05481 713604004939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604004940 FeS/SAM binding site; other site 713604004941 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 713604004942 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 713604004943 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 713604004944 Homeodomain-like domain; Region: HTH_23; cl17451 713604004945 Protein of unknown function (DUF433); Region: DUF433; cl01030 713604004946 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604004947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004948 DNA-binding site [nucleotide binding]; DNA binding site 713604004949 FCD domain; Region: FCD; pfam07729 713604004950 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604004951 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 713604004952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604004953 S-adenosylmethionine binding site [chemical binding]; other site 713604004954 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604004955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604004956 DNA-binding site [nucleotide binding]; DNA binding site 713604004957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604004958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604004959 homodimer interface [polypeptide binding]; other site 713604004960 catalytic residue [active] 713604004961 hypothetical protein; Provisional; Region: PRK07236 713604004962 Pilus assembly protein, PilP; Region: PilP; pfam04351 713604004963 short chain dehydrogenase; Provisional; Region: PRK07201 713604004964 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 713604004965 putative NAD(P) binding site [chemical binding]; other site 713604004966 active site 713604004967 putative substrate binding site [chemical binding]; other site 713604004968 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 713604004969 classical (c) SDRs; Region: SDR_c; cd05233 713604004970 NAD(P) binding site [chemical binding]; other site 713604004971 NAD binding site [chemical binding]; other site 713604004972 active site 713604004973 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604004974 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604004975 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604004976 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604004977 DNA binding residues [nucleotide binding] 713604004978 dimer interface [polypeptide binding]; other site 713604004979 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 713604004980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604004981 putative substrate translocation pore; other site 713604004982 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604004983 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604004984 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604004985 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 713604004986 metal binding site [ion binding]; metal-binding site 713604004987 substrate binding pocket [chemical binding]; other site 713604004988 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 713604004989 classical (c) SDRs; Region: SDR_c; cd05233 713604004990 NAD(P) binding site [chemical binding]; other site 713604004991 active site 713604004992 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 713604004993 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604004994 ligand binding site [chemical binding]; other site 713604004995 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604004996 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604004997 Walker A/P-loop; other site 713604004998 ATP binding site [chemical binding]; other site 713604004999 Q-loop/lid; other site 713604005000 ABC transporter signature motif; other site 713604005001 Walker B; other site 713604005002 D-loop; other site 713604005003 H-loop/switch region; other site 713604005004 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604005005 ABC transporter; Region: ABC_tran; pfam00005 713604005006 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604005007 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604005008 TM-ABC transporter signature motif; other site 713604005009 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604005010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005011 DNA-binding site [nucleotide binding]; DNA binding site 713604005012 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604005013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604005014 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604005015 active site 713604005016 catalytic tetrad [active] 713604005017 Amidohydrolase; Region: Amidohydro_2; pfam04909 713604005018 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 713604005019 active site 713604005020 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 713604005021 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604005022 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604005023 DNA binding residues [nucleotide binding] 713604005024 Domain of unknown function (DUF202); Region: DUF202; cl09954 713604005025 Domain of unknown function (DUF202); Region: DUF202; cl09954 713604005026 GtrA-like protein; Region: GtrA; pfam04138 713604005027 transcription termination factor Rho; Provisional; Region: PRK12678 713604005028 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 713604005029 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 713604005030 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 713604005031 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 713604005032 dimerization interface [polypeptide binding]; other site 713604005033 ligand binding site [chemical binding]; other site 713604005034 NADP binding site [chemical binding]; other site 713604005035 catalytic site [active] 713604005036 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 713604005037 Melibiase; Region: Melibiase; pfam02065 713604005038 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604005039 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604005040 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604005041 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604005042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604005043 dimer interface [polypeptide binding]; other site 713604005044 conserved gate region; other site 713604005045 ABC-ATPase subunit interface; other site 713604005046 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604005047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604005048 dimer interface [polypeptide binding]; other site 713604005049 conserved gate region; other site 713604005050 putative PBP binding loops; other site 713604005051 ABC-ATPase subunit interface; other site 713604005052 alpha-galactosidase; Region: PLN02808; cl17638 713604005053 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 713604005054 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 713604005055 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 713604005056 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604005057 dimer interface [polypeptide binding]; other site 713604005058 active site 713604005059 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 713604005060 heterodimer interface [polypeptide binding]; other site 713604005061 multimer interface [polypeptide binding]; other site 713604005062 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 713604005063 active site 713604005064 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 713604005065 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 713604005066 heterodimer interface [polypeptide binding]; other site 713604005067 active site 713604005068 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604005069 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604005070 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604005071 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604005072 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 713604005073 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604005074 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604005075 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 713604005076 metal-binding site 713604005077 MoxR-like ATPases [General function prediction only]; Region: COG0714 713604005078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604005079 Walker A motif; other site 713604005080 ATP binding site [chemical binding]; other site 713604005081 Walker B motif; other site 713604005082 arginine finger; other site 713604005083 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 713604005084 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 713604005085 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 713604005086 metal ion-dependent adhesion site (MIDAS); other site 713604005087 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 713604005088 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 713604005089 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 713604005090 XdhC Rossmann domain; Region: XdhC_C; pfam13478 713604005091 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604005092 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604005093 catalytic loop [active] 713604005094 iron binding site [ion binding]; other site 713604005095 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604005096 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 713604005097 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604005098 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604005099 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604005100 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 713604005101 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 713604005102 putative hydrophobic ligand binding site [chemical binding]; other site 713604005103 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604005104 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604005105 metal binding site [ion binding]; metal-binding site 713604005106 active site 713604005107 I-site; other site 713604005108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604005109 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604005110 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604005111 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604005112 active site 713604005113 catalytic tetrad [active] 713604005114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005116 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604005117 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 713604005118 sugar binding site [chemical binding]; other site 713604005119 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604005120 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604005121 active site 713604005122 metal binding site [ion binding]; metal-binding site 713604005123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604005124 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604005125 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 713604005126 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604005127 PYR/PP interface [polypeptide binding]; other site 713604005128 dimer interface [polypeptide binding]; other site 713604005129 TPP binding site [chemical binding]; other site 713604005130 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604005131 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604005132 TPP-binding site [chemical binding]; other site 713604005133 KduI/IolB family; Region: KduI; pfam04962 713604005134 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604005135 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 713604005136 substrate binding site [chemical binding]; other site 713604005137 ATP binding site [chemical binding]; other site 713604005138 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604005139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604005140 Walker A/P-loop; other site 713604005141 ATP binding site [chemical binding]; other site 713604005142 Q-loop/lid; other site 713604005143 ABC transporter signature motif; other site 713604005144 Walker B; other site 713604005145 D-loop; other site 713604005146 H-loop/switch region; other site 713604005147 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604005148 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604005149 TM-ABC transporter signature motif; other site 713604005150 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 713604005151 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604005152 putative ligand binding site [chemical binding]; other site 713604005153 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604005154 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604005155 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604005156 DNA binding site [nucleotide binding] 713604005157 domain linker motif; other site 713604005158 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604005159 dimerization interface [polypeptide binding]; other site 713604005160 ligand binding site [chemical binding]; other site 713604005161 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604005162 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604005163 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604005164 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 713604005165 active site 713604005166 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 713604005167 dimer interface [polypeptide binding]; other site 713604005168 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 713604005169 Ligand Binding Site [chemical binding]; other site 713604005170 Molecular Tunnel; other site 713604005171 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 713604005172 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 713604005173 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604005174 Soluble P-type ATPase [General function prediction only]; Region: COG4087 713604005175 K+-transporting ATPase, c chain; Region: KdpC; cl00944 713604005176 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 713604005177 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 713604005178 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 713604005179 Ligand Binding Site [chemical binding]; other site 713604005180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604005181 dimer interface [polypeptide binding]; other site 713604005182 phosphorylation site [posttranslational modification] 713604005183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604005184 ATP binding site [chemical binding]; other site 713604005185 Mg2+ binding site [ion binding]; other site 713604005186 G-X-G motif; other site 713604005187 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 713604005188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604005189 active site 713604005190 phosphorylation site [posttranslational modification] 713604005191 intermolecular recognition site; other site 713604005192 dimerization interface [polypeptide binding]; other site 713604005193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604005194 DNA binding site [nucleotide binding] 713604005195 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604005196 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604005197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005199 acylphosphatase; Provisional; Region: PRK14422 713604005200 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 713604005201 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 713604005202 Walker A/P-loop; other site 713604005203 ATP binding site [chemical binding]; other site 713604005204 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 713604005205 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 713604005206 ABC transporter signature motif; other site 713604005207 Walker B; other site 713604005208 D-loop; other site 713604005209 H-loop/switch region; other site 713604005210 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 713604005211 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 713604005212 Na binding site [ion binding]; other site 713604005213 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 713604005214 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 713604005215 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 713604005216 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604005217 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604005218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604005219 Coenzyme A binding pocket [chemical binding]; other site 713604005220 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604005221 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604005222 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604005223 malate synthase A; Region: malate_syn_A; TIGR01344 713604005224 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 713604005225 active site 713604005226 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 713604005227 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 713604005228 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604005229 MarR family; Region: MarR_2; pfam12802 713604005230 MarR family; Region: MarR_2; cl17246 713604005231 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 713604005232 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604005233 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 713604005234 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 713604005235 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604005236 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604005237 catalytic loop [active] 713604005238 iron binding site [ion binding]; other site 713604005239 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604005240 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 713604005241 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 713604005242 active site 713604005243 putative substrate binding pocket [chemical binding]; other site 713604005244 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 713604005245 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604005246 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604005247 alpha-galactosidase; Region: PLN02808; cl17638 713604005248 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604005249 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604005250 putative sugar binding sites [chemical binding]; other site 713604005251 Q-X-W motif; other site 713604005252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005254 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604005255 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604005256 urate oxidase; Region: urate_oxi; TIGR03383 713604005257 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 713604005258 active site 713604005259 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 713604005260 active site 713604005261 homotetramer interface [polypeptide binding]; other site 713604005262 putative OHCU decarboxylase; Provisional; Region: PRK13798 713604005263 Domain of unknown function DUF77; Region: DUF77; cl00307 713604005264 HTH domain; Region: HTH_22; pfam13309 713604005265 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 713604005266 allantoinase; Region: allantoinase; TIGR03178 713604005267 active site 713604005268 allantoicase; Provisional; Region: PRK13257 713604005269 Allantoicase repeat; Region: Allantoicase; pfam03561 713604005270 Allantoicase repeat; Region: Allantoicase; pfam03561 713604005271 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 713604005272 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 713604005273 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 713604005274 homodimer interface [polypeptide binding]; other site 713604005275 substrate-cofactor binding pocket; other site 713604005276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604005277 catalytic residue [active] 713604005278 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 713604005279 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005280 NAD(P) binding site [chemical binding]; other site 713604005281 active site 713604005282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604005284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604005285 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604005286 putative dimerization interface [polypeptide binding]; other site 713604005287 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604005288 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604005289 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604005290 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 713604005291 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 713604005292 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 713604005293 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 713604005294 Nitrogen regulatory protein P-II; Region: P-II; smart00938 713604005295 PII uridylyl-transferase; Provisional; Region: PRK03381 713604005296 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 713604005297 metal binding triad; other site 713604005298 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 713604005299 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604005300 Zn2+ binding site [ion binding]; other site 713604005301 Mg2+ binding site [ion binding]; other site 713604005302 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 713604005303 hypothetical protein; Provisional; Region: PRK06834 713604005304 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604005305 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 713604005306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005307 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604005308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604005309 metal binding site [ion binding]; metal-binding site 713604005310 active site 713604005311 I-site; other site 713604005312 short chain dehydrogenase; Provisional; Region: PRK06172 713604005313 classical (c) SDRs; Region: SDR_c; cd05233 713604005314 NAD(P) binding site [chemical binding]; other site 713604005315 active site 713604005316 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005318 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 713604005319 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 713604005320 heterodimer interface [polypeptide binding]; other site 713604005321 DNA binding site [nucleotide binding] 713604005322 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604005323 MarR family; Region: MarR_2; cl17246 713604005324 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604005325 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604005326 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 713604005327 Walker A/P-loop; other site 713604005328 ATP binding site [chemical binding]; other site 713604005329 Q-loop/lid; other site 713604005330 ABC transporter signature motif; other site 713604005331 Walker B; other site 713604005332 D-loop; other site 713604005333 H-loop/switch region; other site 713604005334 signal recognition particle protein; Provisional; Region: PRK10867 713604005335 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 713604005336 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 713604005337 P loop; other site 713604005338 GTP binding site [chemical binding]; other site 713604005339 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 713604005340 Signal peptide binding domain; Region: SRP_SPB; pfam02978 713604005341 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604005342 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604005343 active site 713604005344 CAAX protease self-immunity; Region: Abi; pfam02517 713604005345 CAAX protease self-immunity; Region: Abi; pfam02517 713604005346 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 713604005347 hypothetical protein; Provisional; Region: PRK02821 713604005348 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 713604005349 G-X-X-G motif; other site 713604005350 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 713604005351 RimM N-terminal domain; Region: RimM; pfam01782 713604005352 PRC-barrel domain; Region: PRC; pfam05239 713604005353 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 713604005354 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 713604005355 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 713604005356 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 713604005357 Catalytic site [active] 713604005358 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 713604005359 RNA/DNA hybrid binding site [nucleotide binding]; other site 713604005360 active site 713604005361 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 713604005362 hypothetical protein; Reviewed; Region: PRK12497 713604005363 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 713604005364 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 713604005365 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 713604005366 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 713604005367 DNA protecting protein DprA; Region: dprA; TIGR00732 713604005368 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 713604005369 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 713604005370 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604005371 active site 713604005372 DNA binding site [nucleotide binding] 713604005373 Int/Topo IB signature motif; other site 713604005374 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 713604005375 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604005376 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604005377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604005378 DNA binding residues [nucleotide binding] 713604005379 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 713604005380 Peptidase family M23; Region: Peptidase_M23; pfam01551 713604005381 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 713604005382 rRNA interaction site [nucleotide binding]; other site 713604005383 S8 interaction site; other site 713604005384 putative laminin-1 binding site; other site 713604005385 elongation factor Ts; Provisional; Region: tsf; PRK09377 713604005386 UBA/TS-N domain; Region: UBA; pfam00627 713604005387 Elongation factor TS; Region: EF_TS; pfam00889 713604005388 Elongation factor TS; Region: EF_TS; pfam00889 713604005389 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 713604005390 putative nucleotide binding site [chemical binding]; other site 713604005391 uridine monophosphate binding site [chemical binding]; other site 713604005392 homohexameric interface [polypeptide binding]; other site 713604005393 ribosome recycling factor; Reviewed; Region: frr; PRK00083 713604005394 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 713604005395 hinge region; other site 713604005396 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 713604005397 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 713604005398 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604005399 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604005400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604005401 S-adenosylmethionine binding site [chemical binding]; other site 713604005402 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604005403 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604005404 dimerization interface [polypeptide binding]; other site 713604005405 putative DNA binding site [nucleotide binding]; other site 713604005406 putative Zn2+ binding site [ion binding]; other site 713604005407 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 713604005408 putative PBP binding regions; other site 713604005409 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 713604005410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604005411 Walker A/P-loop; other site 713604005412 ATP binding site [chemical binding]; other site 713604005413 Q-loop/lid; other site 713604005414 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 713604005415 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 713604005416 siderophore binding site; other site 713604005417 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604005418 TPP-binding site [chemical binding]; other site 713604005419 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 713604005420 PYR/PP interface [polypeptide binding]; other site 713604005421 dimer interface [polypeptide binding]; other site 713604005422 TPP binding site [chemical binding]; other site 713604005423 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 713604005424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604005425 FeS/SAM binding site; other site 713604005426 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 713604005427 PA14 domain; Region: PA14; cl08459 713604005428 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604005429 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604005430 Creatinine amidohydrolase; Region: Creatininase; pfam02633 713604005431 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604005432 FAD binding domain; Region: FAD_binding_4; pfam01565 713604005433 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604005434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604005435 dimer interface [polypeptide binding]; other site 713604005436 conserved gate region; other site 713604005437 putative PBP binding loops; other site 713604005438 ABC-ATPase subunit interface; other site 713604005439 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604005440 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604005441 Walker A/P-loop; other site 713604005442 ATP binding site [chemical binding]; other site 713604005443 Q-loop/lid; other site 713604005444 ABC transporter signature motif; other site 713604005445 Walker B; other site 713604005446 D-loop; other site 713604005447 H-loop/switch region; other site 713604005448 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 713604005449 cytosine deaminase; Provisional; Region: PRK05985 713604005450 active site 713604005451 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604005452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604005453 non-specific DNA binding site [nucleotide binding]; other site 713604005454 salt bridge; other site 713604005455 sequence-specific DNA binding site [nucleotide binding]; other site 713604005456 Cupin domain; Region: Cupin_2; pfam07883 713604005457 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 713604005458 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 713604005459 FMN-binding pocket [chemical binding]; other site 713604005460 flavin binding motif; other site 713604005461 phosphate binding motif [ion binding]; other site 713604005462 beta-alpha-beta structure motif; other site 713604005463 NAD binding pocket [chemical binding]; other site 713604005464 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604005465 catalytic loop [active] 713604005466 iron binding site [ion binding]; other site 713604005467 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604005468 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 713604005469 active site 713604005470 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 713604005471 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 713604005472 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 713604005473 putative [Fe4-S4] binding site [ion binding]; other site 713604005474 putative molybdopterin cofactor binding site [chemical binding]; other site 713604005475 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 713604005476 putative molybdopterin cofactor binding site; other site 713604005477 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604005478 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604005479 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604005480 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 713604005481 DNA binding residues [nucleotide binding] 713604005482 putative dimer interface [polypeptide binding]; other site 713604005483 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604005484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604005485 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 713604005486 MoaE interaction surface [polypeptide binding]; other site 713604005487 MoeB interaction surface [polypeptide binding]; other site 713604005488 thiocarboxylated glycine; other site 713604005489 VPS10 domain; Region: VPS10; smart00602 713604005490 VPS10 domain; Region: VPS10; smart00602 713604005491 YCII-related domain; Region: YCII; cl00999 713604005492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005493 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604005494 NAD(P) binding site [chemical binding]; other site 713604005495 active site 713604005496 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604005497 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 713604005498 putative NAD(P) binding site [chemical binding]; other site 713604005499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604005500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604005501 non-specific DNA binding site [nucleotide binding]; other site 713604005502 salt bridge; other site 713604005503 sequence-specific DNA binding site [nucleotide binding]; other site 713604005504 YCII-related domain; Region: YCII; cl00999 713604005505 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604005506 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604005507 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604005508 DNA binding residues [nucleotide binding] 713604005509 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604005510 substrate binding site [chemical binding]; other site 713604005511 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604005512 oxyanion hole (OAH) forming residues; other site 713604005513 trimer interface [polypeptide binding]; other site 713604005514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005516 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 713604005517 ArsC family; Region: ArsC; pfam03960 713604005518 catalytic residues [active] 713604005519 threonine synthase; Validated; Region: PRK08197 713604005520 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 713604005521 homodimer interface [polypeptide binding]; other site 713604005522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604005523 catalytic residue [active] 713604005524 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 713604005525 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604005526 classical (c) SDRs; Region: SDR_c; cd05233 713604005527 NAD(P) binding site [chemical binding]; other site 713604005528 active site 713604005529 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604005530 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604005531 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604005532 dimerization interface [polypeptide binding]; other site 713604005533 substrate binding pocket [chemical binding]; other site 713604005534 Cytochrome P450; Region: p450; cl12078 713604005535 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604005536 Cytochrome P450; Region: p450; cl12078 713604005537 Serine hydrolase; Region: Ser_hydrolase; cl17834 713604005538 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604005539 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604005540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604005541 non-specific DNA binding site [nucleotide binding]; other site 713604005542 salt bridge; other site 713604005543 sequence-specific DNA binding site [nucleotide binding]; other site 713604005544 AAA domain; Region: AAA_22; pfam13401 713604005545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604005546 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604005547 binding surface 713604005548 TPR motif; other site 713604005549 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604005550 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604005551 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604005552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604005553 binding surface 713604005554 TPR motif; other site 713604005555 TPR repeat; Region: TPR_11; pfam13414 713604005556 hypothetical protein; Provisional; Region: PRK08317 713604005557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604005558 S-adenosylmethionine binding site [chemical binding]; other site 713604005559 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604005560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005561 DNA-binding site [nucleotide binding]; DNA binding site 713604005562 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604005563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604005564 homodimer interface [polypeptide binding]; other site 713604005565 catalytic residue [active] 713604005566 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604005567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604005568 putative substrate translocation pore; other site 713604005569 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 713604005570 active site 713604005571 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 713604005572 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 713604005573 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 713604005574 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 713604005575 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 713604005576 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 713604005577 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 713604005578 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 713604005579 putative substrate binding region [chemical binding]; other site 713604005580 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 713604005581 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 713604005582 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 713604005583 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604005584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604005585 S-adenosylmethionine binding site [chemical binding]; other site 713604005586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604005587 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604005588 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 713604005589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604005590 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 713604005591 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 713604005592 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604005593 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 713604005594 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 713604005595 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 713604005596 active site 713604005597 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604005598 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604005599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604005600 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604005601 Walker A/P-loop; other site 713604005602 ATP binding site [chemical binding]; other site 713604005603 Q-loop/lid; other site 713604005604 ABC transporter signature motif; other site 713604005605 Walker B; other site 713604005606 D-loop; other site 713604005607 H-loop/switch region; other site 713604005608 Uncharacterized conserved protein [Function unknown]; Region: COG3595 713604005609 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604005610 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604005611 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005612 DNA-binding site [nucleotide binding]; DNA binding site 713604005613 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604005614 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 713604005615 mycothione reductase; Reviewed; Region: PRK07846 713604005616 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604005617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604005618 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604005619 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 713604005620 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 713604005621 cleavage site 713604005622 active site 713604005623 substrate binding sites [chemical binding]; other site 713604005624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604005625 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 713604005626 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604005627 catalytic residue [active] 713604005628 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 713604005629 DEAD-like helicases superfamily; Region: DEXDc; smart00487 713604005630 ATP binding site [chemical binding]; other site 713604005631 Mg++ binding site [ion binding]; other site 713604005632 motif III; other site 713604005633 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604005634 nucleotide binding region [chemical binding]; other site 713604005635 ATP-binding site [chemical binding]; other site 713604005636 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 713604005637 ATP binding site [chemical binding]; other site 713604005638 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 713604005639 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604005640 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604005641 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604005642 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604005643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604005644 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604005645 dimerization interface [polypeptide binding]; other site 713604005646 substrate binding pocket [chemical binding]; other site 713604005647 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 713604005648 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 713604005649 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604005650 hypothetical protein; Validated; Region: PRK02101 713604005651 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604005652 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604005653 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 713604005654 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604005655 putative ligand binding site [chemical binding]; other site 713604005656 putative NAD binding site [chemical binding]; other site 713604005657 catalytic site [active] 713604005658 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 713604005659 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604005660 active site 713604005661 prolyl-tRNA synthetase; Provisional; Region: PRK09194 713604005662 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 713604005663 dimer interface [polypeptide binding]; other site 713604005664 motif 1; other site 713604005665 active site 713604005666 motif 2; other site 713604005667 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 713604005668 putative deacylase active site [active] 713604005669 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604005670 active site 713604005671 motif 3; other site 713604005672 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 713604005673 anticodon binding site; other site 713604005674 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 713604005675 Predicted membrane protein [Function unknown]; Region: COG2733 713604005676 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604005677 RHS Repeat; Region: RHS_repeat; pfam05593 713604005678 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604005679 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 713604005680 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 713604005681 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604005682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604005683 active site 713604005684 phosphorylation site [posttranslational modification] 713604005685 intermolecular recognition site; other site 713604005686 dimerization interface [polypeptide binding]; other site 713604005687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604005688 DNA binding residues [nucleotide binding] 713604005689 Putative sensor; Region: Sensor; pfam13796 713604005690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604005691 Histidine kinase; Region: HisKA_3; pfam07730 713604005692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604005693 ATP binding site [chemical binding]; other site 713604005694 Mg2+ binding site [ion binding]; other site 713604005695 G-X-G motif; other site 713604005696 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 713604005697 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 713604005698 putative di-iron ligands [ion binding]; other site 713604005699 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 713604005700 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 713604005701 FAD binding pocket [chemical binding]; other site 713604005702 FAD binding motif [chemical binding]; other site 713604005703 phosphate binding motif [ion binding]; other site 713604005704 beta-alpha-beta structure motif; other site 713604005705 NAD binding pocket [chemical binding]; other site 713604005706 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604005707 catalytic loop [active] 713604005708 iron binding site [ion binding]; other site 713604005709 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 713604005710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005711 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 713604005712 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 713604005713 ligand binding site [chemical binding]; other site 713604005714 homodimer interface [polypeptide binding]; other site 713604005715 NAD(P) binding site [chemical binding]; other site 713604005716 trimer interface B [polypeptide binding]; other site 713604005717 trimer interface A [polypeptide binding]; other site 713604005718 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 713604005719 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 713604005720 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 713604005721 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 713604005722 Lsr2; Region: Lsr2; pfam11774 713604005723 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 713604005724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604005725 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604005726 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 713604005727 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 713604005728 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 713604005729 dimer interface [polypeptide binding]; other site 713604005730 active site 713604005731 acyl carrier protein; Provisional; Region: acpP; PRK00982 713604005732 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 713604005733 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 713604005734 dimer interface [polypeptide binding]; other site 713604005735 active site 713604005736 CoA binding pocket [chemical binding]; other site 713604005737 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 713604005738 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 713604005739 putative dimer interface [polypeptide binding]; other site 713604005740 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604005741 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604005742 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 713604005743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604005744 Walker A/P-loop; other site 713604005745 ATP binding site [chemical binding]; other site 713604005746 Q-loop/lid; other site 713604005747 ABC transporter signature motif; other site 713604005748 Walker B; other site 713604005749 D-loop; other site 713604005750 H-loop/switch region; other site 713604005751 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 713604005752 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604005753 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 713604005754 L-lactate permease; Region: Lactate_perm; cl00701 713604005755 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 713604005756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005758 short chain dehydrogenase; Provisional; Region: PRK06500 713604005759 classical (c) SDRs; Region: SDR_c; cd05233 713604005760 NAD(P) binding site [chemical binding]; other site 713604005761 active site 713604005762 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 713604005763 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604005764 phosphate binding site [ion binding]; other site 713604005765 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 713604005766 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 713604005767 dimer interface [polypeptide binding]; other site 713604005768 TPP-binding site [chemical binding]; other site 713604005769 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 713604005770 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 713604005771 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 713604005772 dimer interface [polypeptide binding]; other site 713604005773 catalytic triad [active] 713604005774 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 713604005775 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 713604005776 catalytic residues [active] 713604005777 catalytic nucleophile [active] 713604005778 Recombinase; Region: Recombinase; pfam07508 713604005779 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 713604005780 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 713604005781 DNA methylase; Region: N6_N4_Mtase; pfam01555 713604005782 Replication-relaxation; Region: Replic_Relax; pfam13814 713604005783 AAA-like domain; Region: AAA_10; pfam12846 713604005784 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604005785 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 713604005786 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 713604005787 Zn binding site [ion binding]; other site 713604005788 Immunity protein Imm1; Region: Imm1; pfam14430 713604005789 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 713604005790 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604005791 cleavage site 713604005792 active site 713604005793 substrate binding sites [chemical binding]; other site 713604005794 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 713604005795 catalytic residues [active] 713604005796 catalytic nucleophile [active] 713604005797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604005798 non-specific DNA binding site [nucleotide binding]; other site 713604005799 salt bridge; other site 713604005800 sequence-specific DNA binding site [nucleotide binding]; other site 713604005801 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604005802 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604005803 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 713604005804 ATP binding site [chemical binding]; other site 713604005805 substrate interface [chemical binding]; other site 713604005806 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 713604005807 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604005808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604005809 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 713604005810 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 713604005811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604005812 putative substrate translocation pore; other site 713604005813 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604005814 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604005815 MarR family; Region: MarR_2; pfam12802 713604005816 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604005817 Cupin domain; Region: Cupin_2; pfam07883 713604005818 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604005819 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604005820 active site 713604005821 oxidoreductase; Provisional; Region: PRK06196 713604005822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005823 NAD(P) binding site [chemical binding]; other site 713604005824 active site 713604005825 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604005826 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604005827 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604005828 catalytic residue [active] 713604005829 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604005830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005831 DNA-binding site [nucleotide binding]; DNA binding site 713604005832 FCD domain; Region: FCD; pfam07729 713604005833 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 713604005834 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604005835 active site 713604005836 metal binding site [ion binding]; metal-binding site 713604005837 hexamer interface [polypeptide binding]; other site 713604005838 Predicted acyl esterases [General function prediction only]; Region: COG2936 713604005839 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604005840 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 713604005841 Aspartase; Region: Aspartase; cd01357 713604005842 active sites [active] 713604005843 tetramer interface [polypeptide binding]; other site 713604005844 L-asparaginase II; Region: Asparaginase_II; pfam06089 713604005845 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 713604005846 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604005847 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005848 DNA-binding site [nucleotide binding]; DNA binding site 713604005849 FCD domain; Region: FCD; pfam07729 713604005850 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 713604005851 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 713604005852 active site 713604005853 PHP Thumb interface [polypeptide binding]; other site 713604005854 metal binding site [ion binding]; metal-binding site 713604005855 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 713604005856 generic binding surface II; other site 713604005857 generic binding surface I; other site 713604005858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604005859 putative substrate translocation pore; other site 713604005860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604005861 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 713604005862 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 713604005863 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 713604005864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 713604005865 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604005866 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 713604005867 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 713604005868 nucleophile elbow; other site 713604005869 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604005870 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 713604005871 lipoyl synthase; Provisional; Region: PRK05481 713604005872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604005873 FeS/SAM binding site; other site 713604005874 short chain dehydrogenase; Provisional; Region: PRK06197 713604005875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005876 NAD(P) binding site [chemical binding]; other site 713604005877 active site 713604005878 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604005879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604005880 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604005881 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604005882 lipoate-protein ligase B; Provisional; Region: PRK14345 713604005883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604005884 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 713604005885 NAD(P) binding site [chemical binding]; other site 713604005886 active site 713604005887 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 713604005888 E3 interaction surface; other site 713604005889 lipoyl attachment site [posttranslational modification]; other site 713604005890 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 713604005891 E3 interaction surface; other site 713604005892 lipoyl attachment site [posttranslational modification]; other site 713604005893 e3 binding domain; Region: E3_binding; pfam02817 713604005894 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 713604005895 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 713604005896 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 713604005897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604005898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604005899 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604005900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604005901 Coenzyme A binding pocket [chemical binding]; other site 713604005902 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 713604005903 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 713604005904 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 713604005905 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 713604005906 multifunctional aminopeptidase A; Provisional; Region: PRK00913 713604005907 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 713604005908 interface (dimer of trimers) [polypeptide binding]; other site 713604005909 Substrate-binding/catalytic site; other site 713604005910 Zn-binding sites [ion binding]; other site 713604005911 Protein of unknown function (DUF402); Region: DUF402; pfam04167 713604005912 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 713604005913 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 713604005914 homodimer interface [polypeptide binding]; other site 713604005915 substrate-cofactor binding pocket; other site 713604005916 catalytic residue [active] 713604005917 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 713604005918 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 713604005919 putative dimer interface [polypeptide binding]; other site 713604005920 active site pocket [active] 713604005921 putative cataytic base [active] 713604005922 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 713604005923 substrate binding site; other site 713604005924 dimer interface; other site 713604005925 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604005926 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604005927 DNA-binding site [nucleotide binding]; DNA binding site 713604005928 UTRA domain; Region: UTRA; cl17743 713604005929 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 713604005930 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 713604005931 ATP binding site [chemical binding]; other site 713604005932 active site 713604005933 substrate binding site [chemical binding]; other site 713604005934 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604005935 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604005936 active site 713604005937 catalytic tetrad [active] 713604005938 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 713604005939 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 713604005940 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604005941 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 713604005942 substrate binding site [chemical binding]; other site 713604005943 ATP binding site [chemical binding]; other site 713604005944 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 713604005945 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 713604005946 active site 713604005947 dimer interface [polypeptide binding]; other site 713604005948 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 713604005949 Ligand Binding Site [chemical binding]; other site 713604005950 Molecular Tunnel; other site 713604005951 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 713604005952 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 713604005953 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 713604005954 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604005955 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604005956 conserved cys residue [active] 713604005957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604005958 EamA-like transporter family; Region: EamA; pfam00892 713604005959 EamA-like transporter family; Region: EamA; pfam00892 713604005960 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 713604005961 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 713604005962 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 713604005963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 713604005964 active site 713604005965 phosphorylation site [posttranslational modification] 713604005966 intermolecular recognition site; other site 713604005967 dimerization interface [polypeptide binding]; other site 713604005968 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 713604005969 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 713604005970 Cytochrome c; Region: Cytochrom_C; pfam00034 713604005971 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 713604005972 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 713604005973 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604005974 iron-sulfur cluster [ion binding]; other site 713604005975 [2Fe-2S] cluster binding site [ion binding]; other site 713604005976 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 713604005977 heme bH binding site [chemical binding]; other site 713604005978 Qi binding site; other site 713604005979 intrachain domain interface; other site 713604005980 heme bL binding site [chemical binding]; other site 713604005981 interchain domain interface [polypeptide binding]; other site 713604005982 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 713604005983 Qo binding site; other site 713604005984 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 713604005985 intrachain domain interface; other site 713604005986 Qi binding site; other site 713604005987 Qo binding site; other site 713604005988 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604005989 AsnC family; Region: AsnC_trans_reg; pfam01037 713604005990 hypothetical protein; Validated; Region: PRK07883 713604005991 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 713604005992 active site 713604005993 catalytic site [active] 713604005994 substrate binding site [chemical binding]; other site 713604005995 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 713604005996 GIY-YIG motif/motif A; other site 713604005997 active site 713604005998 catalytic site [active] 713604005999 putative DNA binding site [nucleotide binding]; other site 713604006000 metal binding site [ion binding]; metal-binding site 713604006001 YacP-like NYN domain; Region: NYN_YacP; cl01491 713604006002 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604006003 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604006004 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604006005 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604006006 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 713604006007 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 713604006008 putative hydrophobic ligand binding site [chemical binding]; other site 713604006009 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604006010 Cytochrome P450; Region: p450; cl12078 713604006011 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604006012 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 713604006013 inhibitor-cofactor binding pocket; inhibition site 713604006014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604006015 catalytic residue [active] 713604006016 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 713604006017 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 713604006018 Sulfate transporter family; Region: Sulfate_transp; pfam00916 713604006019 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 713604006020 active site clefts [active] 713604006021 zinc binding site [ion binding]; other site 713604006022 dimer interface [polypeptide binding]; other site 713604006023 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 713604006024 Sulfate transporter family; Region: Sulfate_transp; pfam00916 713604006025 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 713604006026 active site clefts [active] 713604006027 zinc binding site [ion binding]; other site 713604006028 dimer interface [polypeptide binding]; other site 713604006029 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 713604006030 AAA domain; Region: AAA_26; pfam13500 713604006031 biotin synthase; Validated; Region: PRK06256 713604006032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604006033 FeS/SAM binding site; other site 713604006034 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 713604006035 Peptidase family M48; Region: Peptidase_M48; cl12018 713604006036 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 713604006037 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604006038 nudix motif; other site 713604006039 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 713604006040 quinolinate synthetase; Provisional; Region: PRK09375 713604006041 L-aspartate oxidase; Provisional; Region: PRK06175 713604006042 L-aspartate oxidase; Provisional; Region: PRK07804 713604006043 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 713604006044 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 713604006045 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 713604006046 dimerization interface [polypeptide binding]; other site 713604006047 active site 713604006048 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604006049 catalytic residues [active] 713604006050 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 713604006051 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 713604006052 Proteins of 100 residues with WXG; Region: WXG100; cl02005 713604006053 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604006054 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604006055 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604006056 acyl-activating enzyme (AAE) consensus motif; other site 713604006057 acyl-activating enzyme (AAE) consensus motif; other site 713604006058 AMP binding site [chemical binding]; other site 713604006059 active site 713604006060 CoA binding site [chemical binding]; other site 713604006061 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604006062 cleavage site 713604006063 active site 713604006064 substrate binding sites [chemical binding]; other site 713604006065 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 713604006066 Septum formation; Region: Septum_form; pfam13845 713604006067 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 713604006068 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604006069 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 713604006070 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604006071 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604006072 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 713604006073 Flagellar FliJ protein; Region: FliJ; pfam02050 713604006074 hypothetical protein; Validated; Region: PRK00153 713604006075 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 713604006076 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 713604006077 Protein of unknown function (DUF690); Region: DUF690; cl04939 713604006078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604006079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604006080 active site 713604006081 phosphorylation site [posttranslational modification] 713604006082 intermolecular recognition site; other site 713604006083 dimerization interface [polypeptide binding]; other site 713604006084 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604006085 DNA binding residues [nucleotide binding] 713604006086 dimerization interface [polypeptide binding]; other site 713604006087 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604006088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604006089 active site 713604006090 phosphorylation site [posttranslational modification] 713604006091 intermolecular recognition site; other site 713604006092 dimerization interface [polypeptide binding]; other site 713604006093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604006094 DNA binding residues [nucleotide binding] 713604006095 dimerization interface [polypeptide binding]; other site 713604006096 Predicted amidohydrolase [General function prediction only]; Region: COG0388 713604006097 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 713604006098 putative active site [active] 713604006099 catalytic triad [active] 713604006100 putative dimer interface [polypeptide binding]; other site 713604006101 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 713604006102 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 713604006103 NAD binding site [chemical binding]; other site 713604006104 dimerization interface [polypeptide binding]; other site 713604006105 product binding site; other site 713604006106 substrate binding site [chemical binding]; other site 713604006107 zinc binding site [ion binding]; other site 713604006108 catalytic residues [active] 713604006109 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 713604006110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604006111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604006112 homodimer interface [polypeptide binding]; other site 713604006113 catalytic residue [active] 713604006114 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 713604006115 putative active site pocket [active] 713604006116 4-fold oligomerization interface [polypeptide binding]; other site 713604006117 metal binding residues [ion binding]; metal-binding site 713604006118 3-fold/trimer interface [polypeptide binding]; other site 713604006119 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 713604006120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604006121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006122 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604006123 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604006124 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 713604006125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006126 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 713604006127 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 713604006128 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 713604006129 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 713604006130 DNA binding residues [nucleotide binding] 713604006131 dimer interface [polypeptide binding]; other site 713604006132 [2Fe-2S] cluster binding site [ion binding]; other site 713604006133 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604006134 TPP-binding site [chemical binding]; other site 713604006135 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 713604006136 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 713604006137 PYR/PP interface [polypeptide binding]; other site 713604006138 dimer interface [polypeptide binding]; other site 713604006139 TPP binding site [chemical binding]; other site 713604006140 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 713604006141 nudix motif; other site 713604006142 NIPSNAP; Region: NIPSNAP; pfam07978 713604006143 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006144 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006145 active site 713604006146 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 713604006147 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 713604006148 putative active site [active] 713604006149 oxyanion strand; other site 713604006150 catalytic triad [active] 713604006151 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 713604006152 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 713604006153 catalytic residues [active] 713604006154 classical (c) SDRs; Region: SDR_c; cd05233 713604006155 NAD(P) binding site [chemical binding]; other site 713604006156 active site 713604006157 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604006158 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006159 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 713604006160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 713604006161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604006162 Coenzyme A binding pocket [chemical binding]; other site 713604006163 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 713604006164 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 713604006165 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 713604006166 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604006167 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604006168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604006169 DNA binding residues [nucleotide binding] 713604006170 Phytase; Region: Phytase; cl17685 713604006171 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 713604006172 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 713604006173 substrate binding site [chemical binding]; other site 713604006174 glutamase interaction surface [polypeptide binding]; other site 713604006175 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 713604006176 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 713604006177 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604006178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604006179 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604006180 non-specific DNA binding site [nucleotide binding]; other site 713604006181 salt bridge; other site 713604006182 sequence-specific DNA binding site [nucleotide binding]; other site 713604006183 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 713604006184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604006185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006186 anthranilate synthase component I; Provisional; Region: PRK13571 713604006187 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 713604006188 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 713604006189 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 713604006190 active site 713604006191 ribulose/triose binding site [chemical binding]; other site 713604006192 phosphate binding site [ion binding]; other site 713604006193 substrate (anthranilate) binding pocket [chemical binding]; other site 713604006194 product (indole) binding pocket [chemical binding]; other site 713604006195 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 713604006196 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 713604006197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604006198 catalytic residue [active] 713604006199 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 713604006200 substrate binding site [chemical binding]; other site 713604006201 active site 713604006202 catalytic residues [active] 713604006203 heterodimer interface [polypeptide binding]; other site 713604006204 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604006205 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 713604006206 DNA binding residues [nucleotide binding] 713604006207 putative dimer interface [polypeptide binding]; other site 713604006208 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 713604006209 putative active site [active] 713604006210 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 713604006211 amidase catalytic site [active] 713604006212 Zn binding residues [ion binding]; other site 713604006213 substrate binding site [chemical binding]; other site 713604006214 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 713604006215 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604006216 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 713604006217 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604006218 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 713604006219 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 713604006220 metal binding site [ion binding]; metal-binding site 713604006221 dimer interface [polypeptide binding]; other site 713604006222 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 713604006223 short chain dehydrogenase; Provisional; Region: PRK07814 713604006224 classical (c) SDRs; Region: SDR_c; cd05233 713604006225 NAD(P) binding site [chemical binding]; other site 713604006226 active site 713604006227 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 713604006228 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 713604006229 active site 713604006230 dimer interface [polypeptide binding]; other site 713604006231 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 713604006232 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 713604006233 active site 713604006234 FMN binding site [chemical binding]; other site 713604006235 substrate binding site [chemical binding]; other site 713604006236 3Fe-4S cluster binding site [ion binding]; other site 713604006237 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 713604006238 domain interface; other site 713604006239 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 713604006240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604006241 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 713604006242 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604006243 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 713604006244 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 713604006245 classical (c) SDRs; Region: SDR_c; cd05233 713604006246 NAD(P) binding site [chemical binding]; other site 713604006247 active site 713604006248 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604006249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604006250 salt bridge; other site 713604006251 non-specific DNA binding site [nucleotide binding]; other site 713604006252 sequence-specific DNA binding site [nucleotide binding]; other site 713604006253 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 713604006254 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 713604006255 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 713604006256 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604006257 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604006258 active site 713604006259 ATP binding site [chemical binding]; other site 713604006260 substrate binding site [chemical binding]; other site 713604006261 activation loop (A-loop); other site 713604006262 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604006263 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604006264 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604006265 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604006266 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604006267 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 713604006268 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604006269 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 713604006270 active site lid residues [active] 713604006271 substrate binding pocket [chemical binding]; other site 713604006272 catalytic residues [active] 713604006273 substrate-Mg2+ binding site; other site 713604006274 aspartate-rich region 1; other site 713604006275 aspartate-rich region 2; other site 713604006276 phytoene desaturase; Region: crtI_fam; TIGR02734 713604006277 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604006278 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 713604006279 substrate binding pocket [chemical binding]; other site 713604006280 chain length determination region; other site 713604006281 substrate-Mg2+ binding site; other site 713604006282 catalytic residues [active] 713604006283 aspartate-rich region 1; other site 713604006284 active site lid residues [active] 713604006285 aspartate-rich region 2; other site 713604006286 Alkylmercury lyase; Region: MerB; pfam03243 713604006287 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 713604006288 FAD binding site [chemical binding]; other site 713604006289 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 713604006290 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 713604006291 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 713604006292 putative deacylase active site [active] 713604006293 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604006294 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604006295 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 713604006296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604006297 Coenzyme A binding pocket [chemical binding]; other site 713604006298 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 713604006299 active site 713604006300 catalytic residues [active] 713604006301 metal binding site [ion binding]; metal-binding site 713604006302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604006303 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 713604006304 ATP binding site [chemical binding]; other site 713604006305 putative Mg++ binding site [ion binding]; other site 713604006306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604006307 nucleotide binding region [chemical binding]; other site 713604006308 ATP-binding site [chemical binding]; other site 713604006309 DEAD/H associated; Region: DEAD_assoc; pfam08494 713604006310 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604006311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604006312 putative DNA binding site [nucleotide binding]; other site 713604006313 putative Zn2+ binding site [ion binding]; other site 713604006314 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604006315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006316 D-galactonate transporter; Region: 2A0114; TIGR00893 713604006317 putative substrate translocation pore; other site 713604006318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006319 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 713604006320 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 713604006321 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 713604006322 rod-share determining protein MreBH; Provisional; Region: PRK13929 713604006323 nucleotide binding site [chemical binding]; other site 713604006324 putative NEF/HSP70 interaction site [polypeptide binding]; other site 713604006325 SBD interface [polypeptide binding]; other site 713604006326 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 713604006327 recombinase A; Provisional; Region: recA; PRK09354 713604006328 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 713604006329 hexamer interface [polypeptide binding]; other site 713604006330 Walker A motif; other site 713604006331 ATP binding site [chemical binding]; other site 713604006332 Walker B motif; other site 713604006333 recombination regulator RecX; Reviewed; Region: recX; PRK00117 713604006334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006335 putative substrate translocation pore; other site 713604006336 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 713604006337 active site 713604006338 intersubunit interface [polypeptide binding]; other site 713604006339 catalytic residue [active] 713604006340 phosphogluconate dehydratase; Validated; Region: PRK09054 713604006341 6-phosphogluconate dehydratase; Region: edd; TIGR01196 713604006342 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 713604006343 L-aspartate oxidase; Provisional; Region: PRK06175 713604006344 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 713604006345 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 713604006346 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604006347 catalytic loop [active] 713604006348 iron binding site [ion binding]; other site 713604006349 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 713604006350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604006351 Coenzyme A binding pocket [chemical binding]; other site 713604006352 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604006353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604006354 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604006355 non-specific DNA binding site [nucleotide binding]; other site 713604006356 salt bridge; other site 713604006357 sequence-specific DNA binding site [nucleotide binding]; other site 713604006358 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 713604006359 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 713604006360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604006361 NAD(P) binding site [chemical binding]; other site 713604006362 active site 713604006363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604006364 dimer interface [polypeptide binding]; other site 713604006365 conserved gate region; other site 713604006366 putative PBP binding loops; other site 713604006367 ABC-ATPase subunit interface; other site 713604006368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604006369 dimer interface [polypeptide binding]; other site 713604006370 conserved gate region; other site 713604006371 putative PBP binding loops; other site 713604006372 ABC-ATPase subunit interface; other site 713604006373 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604006374 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604006375 substrate binding pocket [chemical binding]; other site 713604006376 membrane-bound complex binding site; other site 713604006377 hinge residues; other site 713604006378 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 713604006379 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 713604006380 Walker A/P-loop; other site 713604006381 ATP binding site [chemical binding]; other site 713604006382 Q-loop/lid; other site 713604006383 ABC transporter signature motif; other site 713604006384 Walker B; other site 713604006385 D-loop; other site 713604006386 H-loop/switch region; other site 713604006387 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604006388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 713604006389 dimerization interface [polypeptide binding]; other site 713604006390 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604006391 DNA binding site [nucleotide binding] 713604006392 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 713604006393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604006394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604006395 dimer interface [polypeptide binding]; other site 713604006396 phosphorylation site [posttranslational modification] 713604006397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604006398 ATP binding site [chemical binding]; other site 713604006399 Mg2+ binding site [ion binding]; other site 713604006400 G-X-G motif; other site 713604006401 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 713604006402 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 713604006403 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604006404 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604006405 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 713604006406 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 713604006407 active site 713604006408 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 713604006409 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 713604006410 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 713604006411 putative catalytic site [active] 713604006412 putative metal binding site [ion binding]; other site 713604006413 putative phosphate binding site [ion binding]; other site 713604006414 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 713604006415 putative sugar binding site [chemical binding]; other site 713604006416 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604006417 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 713604006418 active site 713604006419 ATP binding site [chemical binding]; other site 713604006420 substrate binding site [chemical binding]; other site 713604006421 activation loop (A-loop); other site 713604006422 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 713604006423 active site 713604006424 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604006425 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604006426 putative sugar binding sites [chemical binding]; other site 713604006427 Q-X-W motif; other site 713604006428 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604006429 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 713604006430 hypothetical protein; Provisional; Region: PRK07236 713604006431 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604006432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006433 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604006434 hypothetical protein; Provisional; Region: PRK06753 713604006435 hypothetical protein; Provisional; Region: PRK07236 713604006436 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 713604006437 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 713604006438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604006439 FeS/SAM binding site; other site 713604006440 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 713604006441 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 713604006442 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 713604006443 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 713604006444 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 713604006445 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 713604006446 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 713604006447 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 713604006448 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 713604006449 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604006450 active site 713604006451 HIGH motif; other site 713604006452 nucleotide binding site [chemical binding]; other site 713604006453 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604006454 active site 713604006455 KMSKS motif; other site 713604006456 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 713604006457 tRNA binding surface [nucleotide binding]; other site 713604006458 anticodon binding site; other site 713604006459 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604006460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604006462 putative DNA binding site [nucleotide binding]; other site 713604006463 putative Zn2+ binding site [ion binding]; other site 713604006464 GTPases [General function prediction only]; Region: HflX; COG2262 713604006465 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 713604006466 HflX GTPase family; Region: HflX; cd01878 713604006467 G1 box; other site 713604006468 GTP/Mg2+ binding site [chemical binding]; other site 713604006469 Switch I region; other site 713604006470 G2 box; other site 713604006471 G3 box; other site 713604006472 Switch II region; other site 713604006473 G4 box; other site 713604006474 G5 box; other site 713604006475 LexA repressor; Validated; Region: PRK00215 713604006476 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 713604006477 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 713604006478 Catalytic site [active] 713604006479 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 713604006480 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 713604006481 ATP cone domain; Region: ATP-cone; pfam03477 713604006482 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 713604006483 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 713604006484 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 713604006485 active site 713604006486 dimer interface [polypeptide binding]; other site 713604006487 effector binding site; other site 713604006488 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 713604006489 TSCPD domain; Region: TSCPD; pfam12637 713604006490 NB-ARC domain; Region: NB-ARC; pfam00931 713604006491 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 713604006492 dinuclear metal binding motif [ion binding]; other site 713604006493 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 713604006494 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 713604006495 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 713604006496 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604006497 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 713604006498 TIGR03086 family protein; Region: TIGR03086 713604006499 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604006500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604006501 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604006502 DNA-binding site [nucleotide binding]; DNA binding site 713604006503 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604006504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604006505 homodimer interface [polypeptide binding]; other site 713604006506 catalytic residue [active] 713604006507 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 713604006508 conserved hypothetical protein; Region: TIGR02231 713604006509 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 713604006510 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 713604006511 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 713604006512 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604006513 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 713604006514 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 713604006515 putative active site [active] 713604006516 FAD binding domain; Region: FAD_binding_4; pfam01565 713604006517 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604006518 Berberine and berberine like; Region: BBE; pfam08031 713604006519 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604006520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604006521 active site 713604006522 phosphorylation site [posttranslational modification] 713604006523 intermolecular recognition site; other site 713604006524 dimerization interface [polypeptide binding]; other site 713604006525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604006526 DNA binding residues [nucleotide binding] 713604006527 dimerization interface [polypeptide binding]; other site 713604006528 Histidine kinase; Region: HisKA_3; pfam07730 713604006529 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604006530 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 713604006531 Peptidase family M23; Region: Peptidase_M23; pfam01551 713604006532 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 713604006533 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 713604006534 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 713604006535 NAD binding site [chemical binding]; other site 713604006536 homodimer interface [polypeptide binding]; other site 713604006537 active site 713604006538 substrate binding site [chemical binding]; other site 713604006539 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 713604006540 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 713604006541 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 713604006542 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 713604006543 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 713604006544 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 713604006545 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 713604006546 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 713604006547 active site residue [active] 713604006548 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 713604006549 active site residue [active] 713604006550 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 713604006551 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 713604006552 active site 713604006553 Zn binding site [ion binding]; other site 713604006554 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604006555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604006556 Coenzyme A binding pocket [chemical binding]; other site 713604006557 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 713604006558 CoA binding domain; Region: CoA_binding_2; pfam13380 713604006559 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 713604006560 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 713604006561 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604006562 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604006563 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006564 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604006565 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006566 active site 713604006567 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006568 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 713604006569 FAD binding site [chemical binding]; other site 713604006570 substrate binding site [chemical binding]; other site 713604006571 catalytic base [active] 713604006572 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604006573 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 713604006574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604006575 NAD(P) binding site [chemical binding]; other site 713604006576 active site 713604006577 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604006578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604006579 NAD(P) binding site [chemical binding]; other site 713604006580 active site 713604006581 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604006582 Permease; Region: Permease; pfam02405 713604006583 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604006584 Permease; Region: Permease; pfam02405 713604006585 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006586 mce related protein; Region: MCE; pfam02470 713604006587 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604006588 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006589 mce related protein; Region: MCE; pfam02470 713604006590 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006591 mce related protein; Region: MCE; pfam02470 713604006592 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006593 mce related protein; Region: MCE; pfam02470 713604006594 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006595 mce related protein; Region: MCE; pfam02470 713604006596 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604006597 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604006598 mce related protein; Region: MCE; pfam02470 713604006599 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 713604006600 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604006601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604006602 homodimer interface [polypeptide binding]; other site 713604006603 catalytic residue [active] 713604006604 Ferritin-like domain; Region: Ferritin_2; pfam13668 713604006605 hypothetical protein; Provisional; Region: PRK07236 713604006606 hypothetical protein; Provisional; Region: PRK06847 713604006607 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604006608 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604006609 DNA binding site [nucleotide binding] 713604006610 domain linker motif; other site 713604006611 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604006612 ligand binding site [chemical binding]; other site 713604006613 dimerization interface [polypeptide binding]; other site 713604006614 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604006615 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604006616 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604006617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604006618 dimer interface [polypeptide binding]; other site 713604006619 putative PBP binding loops; other site 713604006620 ABC-ATPase subunit interface; other site 713604006621 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604006622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604006623 dimer interface [polypeptide binding]; other site 713604006624 conserved gate region; other site 713604006625 putative PBP binding loops; other site 713604006626 ABC-ATPase subunit interface; other site 713604006627 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604006628 beta-galactosidase; Region: BGL; TIGR03356 713604006629 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 713604006630 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 713604006631 acyl-activating enzyme (AAE) consensus motif; other site 713604006632 putative AMP binding site [chemical binding]; other site 713604006633 putative active site [active] 713604006634 putative CoA binding site [chemical binding]; other site 713604006635 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604006636 active site 713604006637 metal binding site [ion binding]; metal-binding site 713604006638 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 713604006639 putative hydrophobic ligand binding site [chemical binding]; other site 713604006640 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 713604006641 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 713604006642 DTAP/Switch II; other site 713604006643 Switch I; other site 713604006644 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 713604006645 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604006646 nucleotide binding site [chemical binding]; other site 713604006647 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604006648 nudix motif; other site 713604006649 YacP-like NYN domain; Region: NYN_YacP; cl01491 713604006650 carboxylate-amine ligase; Provisional; Region: PRK13517 713604006651 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 713604006652 Esterase/lipase [General function prediction only]; Region: COG1647 713604006653 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604006654 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604006655 putative acyl-acceptor binding pocket; other site 713604006656 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 713604006657 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 713604006658 phosphofructokinase; Region: PFK_mixed; TIGR02483 713604006659 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 713604006660 active site 713604006661 ADP/pyrophosphate binding site [chemical binding]; other site 713604006662 dimerization interface [polypeptide binding]; other site 713604006663 allosteric effector site; other site 713604006664 fructose-1,6-bisphosphate binding site; other site 713604006665 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604006666 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604006667 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604006668 DNA binding residues [nucleotide binding] 713604006669 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 713604006670 active sites [active] 713604006671 tetramer interface [polypeptide binding]; other site 713604006672 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 713604006673 heme-binding site [chemical binding]; other site 713604006674 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604006675 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604006676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604006677 dimerization interface [polypeptide binding]; other site 713604006678 putative DNA binding site [nucleotide binding]; other site 713604006679 putative Zn2+ binding site [ion binding]; other site 713604006680 Glyco_18 domain; Region: Glyco_18; smart00636 713604006681 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 713604006682 active site 713604006683 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 713604006684 pyruvate kinase; Provisional; Region: PRK06247 713604006685 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 713604006686 active site 713604006687 domain interfaces; other site 713604006688 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 713604006689 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 713604006690 active site 713604006691 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 713604006692 catalytic triad [active] 713604006693 dimer interface [polypeptide binding]; other site 713604006694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604006695 non-specific DNA binding site [nucleotide binding]; other site 713604006696 sequence-specific DNA binding site [nucleotide binding]; other site 713604006697 salt bridge; other site 713604006698 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604006699 Predicted ATPase [General function prediction only]; Region: COG3899 713604006700 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604006701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604006702 DNA binding residues [nucleotide binding] 713604006703 dimerization interface [polypeptide binding]; other site 713604006704 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 713604006705 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 713604006706 NAD(P) binding site [chemical binding]; other site 713604006707 catalytic residues [active] 713604006708 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 713604006709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006710 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006711 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006712 active site 713604006713 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604006714 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604006715 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604006716 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604006717 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604006718 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604006719 substrate binding site [chemical binding]; other site 713604006720 oxyanion hole (OAH) forming residues; other site 713604006721 trimer interface [polypeptide binding]; other site 713604006722 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 713604006723 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604006724 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604006725 Glucitol operon activator protein (GutM); Region: GutM; cl01890 713604006726 integral membrane protein; Region: integ_memb_HG; TIGR03954 713604006727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006728 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604006729 putative substrate translocation pore; other site 713604006730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604006731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006732 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 713604006733 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 713604006734 Na binding site [ion binding]; other site 713604006735 Protein of unknown function, DUF485; Region: DUF485; pfam04341 713604006736 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604006737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604006738 ATP binding site [chemical binding]; other site 713604006739 Mg2+ binding site [ion binding]; other site 713604006740 G-X-G motif; other site 713604006741 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604006742 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604006743 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604006744 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604006745 G1 box; other site 713604006746 GTP/Mg2+ binding site [chemical binding]; other site 713604006747 G2 box; other site 713604006748 Switch I region; other site 713604006749 G3 box; other site 713604006750 Switch II region; other site 713604006751 G4 box; other site 713604006752 G5 box; other site 713604006753 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 713604006754 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 713604006755 putative hydrophobic ligand binding site [chemical binding]; other site 713604006756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604006757 dimerization interface [polypeptide binding]; other site 713604006758 putative DNA binding site [nucleotide binding]; other site 713604006759 putative Zn2+ binding site [ion binding]; other site 713604006760 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 713604006761 B12 binding site [chemical binding]; other site 713604006762 cobalt ligand [ion binding]; other site 713604006763 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 713604006764 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604006765 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 713604006766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604006767 S-adenosylmethionine binding site [chemical binding]; other site 713604006768 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604006769 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604006770 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604006771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604006772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604006773 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006774 active site 713604006775 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006776 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006777 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006778 active site 713604006779 SNF2 Helicase protein; Region: DUF3670; pfam12419 713604006780 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 713604006781 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604006782 ATP binding site [chemical binding]; other site 713604006783 putative Mg++ binding site [ion binding]; other site 713604006784 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 713604006785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604006786 nucleotide binding region [chemical binding]; other site 713604006787 ATP-binding site [chemical binding]; other site 713604006788 Uncharacterized conserved protein [Function unknown]; Region: COG4279 713604006789 SWIM zinc finger; Region: SWIM; pfam04434 713604006790 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604006791 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604006792 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604006793 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 713604006794 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 713604006795 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604006796 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604006797 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006798 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006799 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006800 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604006801 active site 713604006802 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 713604006803 active site 713604006804 catalytic site [active] 713604006805 DUF35 OB-fold domain; Region: DUF35; pfam01796 713604006806 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604006807 active site 2 [active] 713604006808 active site 1 [active] 713604006809 lipid-transfer protein; Provisional; Region: PRK07855 713604006810 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604006811 active site 713604006812 Riboflavin kinase; Region: Flavokinase; smart00904 713604006813 enoyl-CoA hydratase; Region: PLN02864 713604006814 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 713604006815 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 713604006816 dimer interaction site [polypeptide binding]; other site 713604006817 substrate-binding tunnel; other site 713604006818 active site 713604006819 catalytic site [active] 713604006820 substrate binding site [chemical binding]; other site 713604006821 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 713604006822 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 713604006823 FAD binding pocket [chemical binding]; other site 713604006824 FAD binding motif [chemical binding]; other site 713604006825 phosphate binding motif [ion binding]; other site 713604006826 beta-alpha-beta structure motif; other site 713604006827 NAD(p) ribose binding residues [chemical binding]; other site 713604006828 NAD binding pocket [chemical binding]; other site 713604006829 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 713604006830 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604006831 catalytic loop [active] 713604006832 iron binding site [ion binding]; other site 713604006833 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 713604006834 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 713604006835 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 713604006836 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604006837 hypothetical protein; Validated; Region: PRK07121 713604006838 Predicted oxidoreductase [General function prediction only]; Region: COG3573 713604006839 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604006840 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 713604006841 Flavin binding site [chemical binding]; other site 713604006842 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 713604006843 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604006844 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 713604006845 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 713604006846 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 713604006847 active site 713604006848 Fe binding site [ion binding]; other site 713604006849 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 713604006850 Smr domain; Region: Smr; pfam01713 713604006851 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604006852 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 713604006853 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604006854 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 713604006855 putative di-iron ligands [ion binding]; other site 713604006856 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 713604006857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604006858 Walker A/P-loop; other site 713604006859 ATP binding site [chemical binding]; other site 713604006860 Q-loop/lid; other site 713604006861 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 713604006862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604006863 Walker A/P-loop; other site 713604006864 ATP binding site [chemical binding]; other site 713604006865 Q-loop/lid; other site 713604006866 ABC transporter signature motif; other site 713604006867 Walker B; other site 713604006868 D-loop; other site 713604006869 H-loop/switch region; other site 713604006870 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604006871 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 713604006872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604006873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604006874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604006875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604006876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604006877 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 713604006878 putative substrate binding pocket [chemical binding]; other site 713604006879 putative dimerization interface [polypeptide binding]; other site 713604006880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604006881 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604006882 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604006883 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604006884 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604006885 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 713604006886 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 713604006887 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006888 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006889 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604006890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604006891 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604006892 DNA binding residues [nucleotide binding] 713604006893 Putative zinc-finger; Region: zf-HC2; pfam13490 713604006894 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604006895 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604006896 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006897 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006898 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006899 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604006900 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 713604006901 amidohydrolase; Region: amidohydrolases; TIGR01891 713604006902 metal binding site [ion binding]; metal-binding site 713604006903 dimer interface [polypeptide binding]; other site 713604006904 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604006905 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604006906 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 713604006907 active site 713604006908 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604006909 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604006910 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 713604006911 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604006912 dimer interface [polypeptide binding]; other site 713604006913 active site 713604006914 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604006915 Cytochrome P450; Region: p450; cl12078 713604006916 Dienelactone hydrolase family; Region: DLH; pfam01738 713604006917 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 713604006918 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 713604006919 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 713604006920 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 713604006921 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604006922 active site 713604006923 lipid-transfer protein; Provisional; Region: PRK07937 713604006924 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604006925 active site 713604006926 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 713604006927 DUF35 OB-fold domain; Region: DUF35; pfam01796 713604006928 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 713604006929 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 713604006930 DUF35 OB-fold domain; Region: DUF35; pfam01796 713604006931 enoyl-CoA hydratase; Provisional; Region: PRK07799 713604006932 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604006933 substrate binding site [chemical binding]; other site 713604006934 oxyanion hole (OAH) forming residues; other site 713604006935 trimer interface [polypeptide binding]; other site 713604006936 acyl-CoA synthetase; Validated; Region: PRK07798 713604006937 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604006938 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 713604006939 acyl-activating enzyme (AAE) consensus motif; other site 713604006940 acyl-activating enzyme (AAE) consensus motif; other site 713604006941 putative AMP binding site [chemical binding]; other site 713604006942 putative active site [active] 713604006943 putative CoA binding site [chemical binding]; other site 713604006944 Nitronate monooxygenase; Region: NMO; pfam03060 713604006945 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 713604006946 FMN binding site [chemical binding]; other site 713604006947 substrate binding site [chemical binding]; other site 713604006948 putative catalytic residue [active] 713604006949 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 713604006950 cleavage site 713604006951 active site 713604006952 substrate binding sites [chemical binding]; other site 713604006953 amino acid transporter; Region: 2A0306; TIGR00909 713604006954 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604006955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604006956 DNA-binding site [nucleotide binding]; DNA binding site 713604006957 UTRA domain; Region: UTRA; pfam07702 713604006958 fumarate hydratase; Provisional; Region: PRK15389 713604006959 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 713604006960 Fumarase C-terminus; Region: Fumerase_C; pfam05683 713604006961 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 713604006962 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 713604006963 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604006964 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604006965 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604006966 DNA binding residues [nucleotide binding] 713604006967 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 713604006968 dimerization interface [polypeptide binding]; other site 713604006969 putative tRNAtyr binding site [nucleotide binding]; other site 713604006970 putative active site [active] 713604006971 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 713604006972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604006973 S-adenosylmethionine binding site [chemical binding]; other site 713604006974 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 713604006975 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 713604006976 metal binding site [ion binding]; metal-binding site 713604006977 putative dimer interface [polypeptide binding]; other site 713604006978 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 713604006979 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604006980 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 713604006981 substrate binding site [chemical binding]; other site 713604006982 ATP binding site [chemical binding]; other site 713604006983 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 713604006984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 713604006985 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 713604006986 SpoOM protein; Region: Spo0M; pfam07070 713604006987 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 713604006988 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 713604006989 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 713604006990 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 713604006991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604006992 ATP binding site [chemical binding]; other site 713604006993 putative Mg++ binding site [ion binding]; other site 713604006994 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 713604006995 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 713604006996 putative ligand binding site [chemical binding]; other site 713604006997 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604006998 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604006999 Walker A/P-loop; other site 713604007000 ATP binding site [chemical binding]; other site 713604007001 Q-loop/lid; other site 713604007002 ABC transporter signature motif; other site 713604007003 Walker B; other site 713604007004 D-loop; other site 713604007005 H-loop/switch region; other site 713604007006 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 713604007007 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604007008 TM-ABC transporter signature motif; other site 713604007009 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604007010 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604007011 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 713604007012 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604007013 amino acid transporter; Region: 2A0306; TIGR00909 713604007014 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 713604007015 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 713604007016 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 713604007017 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 713604007018 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 713604007019 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 713604007020 active site 713604007021 catalytic site [active] 713604007022 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 713604007023 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 713604007024 active site 713604007025 catalytic site [active] 713604007026 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 713604007027 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 713604007028 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 713604007029 catalytic site [active] 713604007030 active site 713604007031 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 713604007032 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 713604007033 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 713604007034 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 713604007035 active site 713604007036 catalytic site [active] 713604007037 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 713604007038 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 713604007039 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 713604007040 active site 713604007041 catalytic site [active] 713604007042 trehalose synthase; Region: treS_nterm; TIGR02456 713604007043 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 713604007044 active site 713604007045 catalytic site [active] 713604007046 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 713604007047 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 713604007048 glycogen branching enzyme; Provisional; Region: PRK05402 713604007049 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 713604007050 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 713604007051 active site 713604007052 catalytic site [active] 713604007053 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 713604007054 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 713604007055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604007056 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604007057 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604007058 DNA binding residues [nucleotide binding] 713604007059 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604007060 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604007061 nucleotide binding site [chemical binding]; other site 713604007062 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 713604007063 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 713604007064 active site 713604007065 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 713604007066 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 713604007067 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 713604007068 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 713604007069 trimer interface [polypeptide binding]; other site 713604007070 active site 713604007071 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 713604007072 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 713604007073 generic binding surface II; other site 713604007074 ssDNA binding site; other site 713604007075 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 713604007076 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 713604007077 TrkA-N domain; Region: TrkA_N; pfam02254 713604007078 TrkA-C domain; Region: TrkA_C; pfam02080 713604007079 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 713604007080 TrkA-N domain; Region: TrkA_N; pfam02254 713604007081 TrkA-C domain; Region: TrkA_C; pfam02080 713604007082 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 713604007083 K+ potassium transporter; Region: K_trans; cl15781 713604007084 TRAM domain; Region: TRAM; pfam01938 713604007085 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 713604007086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604007087 S-adenosylmethionine binding site [chemical binding]; other site 713604007088 TIGR03086 family protein; Region: TIGR03086 713604007089 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604007090 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604007091 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 713604007092 NAD(P) binding site [chemical binding]; other site 713604007093 catalytic residues [active] 713604007094 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 713604007095 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 713604007096 TPP-binding site; other site 713604007097 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 713604007098 PYR/PP interface [polypeptide binding]; other site 713604007099 dimer interface [polypeptide binding]; other site 713604007100 TPP binding site [chemical binding]; other site 713604007101 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604007102 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 713604007103 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604007104 ligand binding site [chemical binding]; other site 713604007105 dimerization interface [polypeptide binding]; other site 713604007106 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 713604007107 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 713604007108 tetrameric interface [polypeptide binding]; other site 713604007109 NAD binding site [chemical binding]; other site 713604007110 catalytic residues [active] 713604007111 substrate binding site [chemical binding]; other site 713604007112 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 713604007113 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604007114 PYR/PP interface [polypeptide binding]; other site 713604007115 dimer interface [polypeptide binding]; other site 713604007116 TPP binding site [chemical binding]; other site 713604007117 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604007118 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 713604007119 TPP-binding site [chemical binding]; other site 713604007120 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 713604007121 agmatinase; Region: agmatinase; TIGR01230 713604007122 oligomer interface [polypeptide binding]; other site 713604007123 putative active site [active] 713604007124 Mn binding site [ion binding]; other site 713604007125 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 713604007126 Na binding site [ion binding]; other site 713604007127 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 713604007128 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604007129 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604007130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604007131 active site 713604007132 phosphorylation site [posttranslational modification] 713604007133 intermolecular recognition site; other site 713604007134 dimerization interface [polypeptide binding]; other site 713604007135 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604007136 DNA binding site [nucleotide binding] 713604007137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604007138 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604007139 dimerization interface [polypeptide binding]; other site 713604007140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604007141 dimer interface [polypeptide binding]; other site 713604007142 phosphorylation site [posttranslational modification] 713604007143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604007144 ATP binding site [chemical binding]; other site 713604007145 Mg2+ binding site [ion binding]; other site 713604007146 G-X-G motif; other site 713604007147 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604007148 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604007149 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 713604007150 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 713604007151 active site 713604007152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604007153 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 713604007154 substrate binding site [chemical binding]; other site 713604007155 oxyanion hole (OAH) forming residues; other site 713604007156 trimer interface [polypeptide binding]; other site 713604007157 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604007158 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604007159 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604007160 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 713604007161 dimer interface [polypeptide binding]; other site 713604007162 active site 713604007163 allophanate hydrolase; Provisional; Region: PRK08186 713604007164 Amidase; Region: Amidase; cl11426 713604007165 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604007166 urea carboxylase; Region: urea_carbox; TIGR02712 713604007167 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604007168 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 713604007169 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 713604007170 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 713604007171 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604007172 carboxyltransferase (CT) interaction site; other site 713604007173 biotinylation site [posttranslational modification]; other site 713604007174 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 713604007175 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 713604007176 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 713604007177 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 713604007178 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 713604007179 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 713604007180 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 713604007181 catalytic site [active] 713604007182 putative active site [active] 713604007183 putative substrate binding site [chemical binding]; other site 713604007184 Helicase and RNase D C-terminal; Region: HRDC; smart00341 713604007185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604007186 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604007187 active site 713604007188 phosphorylation site [posttranslational modification] 713604007189 intermolecular recognition site; other site 713604007190 dimerization interface [polypeptide binding]; other site 713604007191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604007192 DNA binding residues [nucleotide binding] 713604007193 dimerization interface [polypeptide binding]; other site 713604007194 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 713604007195 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 713604007196 substrate binding site [chemical binding]; other site 713604007197 active site 713604007198 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 713604007199 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604007200 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 713604007201 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604007202 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604007203 hypothetical protein; Provisional; Region: PRK05409 713604007204 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604007205 TIGR04222 domain; Region: near_uncomplex 713604007206 TIGR04222 domain; Region: near_uncomplex 713604007207 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 713604007208 SelR domain; Region: SelR; pfam01641 713604007209 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604007210 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604007211 active site 713604007212 ATP binding site [chemical binding]; other site 713604007213 substrate binding site [chemical binding]; other site 713604007214 activation loop (A-loop); other site 713604007215 Uncharacterized conserved protein [Function unknown]; Region: COG0398 713604007216 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 713604007217 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 713604007218 nucleotide binding site [chemical binding]; other site 713604007219 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 713604007220 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604007221 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 713604007222 RNA binding site [nucleotide binding]; other site 713604007223 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604007224 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604007225 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 713604007226 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 713604007227 Glutamate binding site [chemical binding]; other site 713604007228 NAD binding site [chemical binding]; other site 713604007229 catalytic residues [active] 713604007230 Proline dehydrogenase; Region: Pro_dh; cl03282 713604007231 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 713604007232 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 713604007233 catalytic residues [active] 713604007234 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 713604007235 YCII-related domain; Region: YCII; cl00999 713604007236 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 713604007237 putative dimer interface [polypeptide binding]; other site 713604007238 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604007239 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604007240 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604007241 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604007242 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604007243 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604007244 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 713604007245 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 713604007246 active site 713604007247 DNA binding site [nucleotide binding] 713604007248 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 713604007249 DNA binding site [nucleotide binding] 713604007250 Asp23 family; Region: Asp23; cl00574 713604007251 Asp23 family; Region: Asp23; pfam03780 713604007252 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 713604007253 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604007254 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604007255 DNA binding residues [nucleotide binding] 713604007256 hypothetical protein; Provisional; Region: PRK14059 713604007257 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 713604007258 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 713604007259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604007260 Walker A motif; other site 713604007261 ATP binding site [chemical binding]; other site 713604007262 Walker B motif; other site 713604007263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604007264 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 713604007265 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 713604007266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 713604007267 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 713604007268 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604007269 inhibitor-cofactor binding pocket; inhibition site 713604007270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604007271 catalytic residue [active] 713604007272 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604007273 dimerization interface [polypeptide binding]; other site 713604007274 putative DNA binding site [nucleotide binding]; other site 713604007275 putative Zn2+ binding site [ion binding]; other site 713604007276 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 713604007277 putative hydrophobic ligand binding site [chemical binding]; other site 713604007278 CLM binding site; other site 713604007279 L1 loop; other site 713604007280 DNA binding site [nucleotide binding] 713604007281 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 713604007282 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 713604007283 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604007284 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 713604007285 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604007286 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 713604007287 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 713604007288 CrcB-like protein; Region: CRCB; pfam02537 713604007289 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 713604007290 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604007291 catalytic residue [active] 713604007292 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 713604007293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604007294 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 713604007295 IucA / IucC family; Region: IucA_IucC; pfam04183 713604007296 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 713604007297 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 713604007298 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 713604007299 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604007300 FAD binding domain; Region: FAD_binding_4; pfam01565 713604007301 Berberine and berberine like; Region: BBE; pfam08031 713604007302 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 713604007303 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 713604007304 AAA ATPase domain; Region: AAA_16; pfam13191 713604007305 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 713604007306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604007307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604007308 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604007309 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 713604007310 protein-splicing catalytic site; other site 713604007311 thioester formation/cholesterol transfer; other site 713604007312 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 713604007313 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 713604007314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604007315 FeS/SAM binding site; other site 713604007316 alkylmercury lyase; Provisional; Region: PRK13239 713604007317 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 713604007318 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 713604007319 dimer interface [polypeptide binding]; other site 713604007320 anticodon binding site; other site 713604007321 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 713604007322 homodimer interface [polypeptide binding]; other site 713604007323 motif 1; other site 713604007324 active site 713604007325 motif 2; other site 713604007326 GAD domain; Region: GAD; pfam02938 713604007327 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604007328 active site 713604007329 motif 3; other site 713604007330 Domain of unknown function (DUF389); Region: DUF389; cl00781 713604007331 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 713604007332 active site 713604007333 catalytic triad [active] 713604007334 oxyanion hole [active] 713604007335 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604007336 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 713604007337 active site 713604007338 metal binding site [ion binding]; metal-binding site 713604007339 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604007340 Cytochrome P450; Region: p450; cl12078 713604007341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007343 recombination factor protein RarA; Reviewed; Region: PRK13342 713604007344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604007345 Walker A motif; other site 713604007346 ATP binding site [chemical binding]; other site 713604007347 Walker B motif; other site 713604007348 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 713604007349 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604007350 active site 713604007351 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 713604007352 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604007353 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 713604007354 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 713604007355 motif 1; other site 713604007356 active site 713604007357 motif 2; other site 713604007358 motif 3; other site 713604007359 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 713604007360 DHHA1 domain; Region: DHHA1; pfam02272 713604007361 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 713604007362 YceG-like family; Region: YceG; pfam02618 713604007363 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 713604007364 dimerization interface [polypeptide binding]; other site 713604007365 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 713604007366 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 713604007367 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 713604007368 shikimate binding site; other site 713604007369 NAD(P) binding site [chemical binding]; other site 713604007370 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 713604007371 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604007372 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604007373 S-adenosylmethionine binding site [chemical binding]; other site 713604007374 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007376 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604007377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 713604007378 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 713604007379 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604007380 dimerization interface [polypeptide binding]; other site 713604007381 NAD binding site [chemical binding]; other site 713604007382 ligand binding site [chemical binding]; other site 713604007383 catalytic site [active] 713604007384 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604007385 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604007386 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 713604007387 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 713604007388 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 713604007389 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604007390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604007391 DNA-binding site [nucleotide binding]; DNA binding site 713604007392 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 713604007393 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 713604007394 active site turn [active] 713604007395 phosphorylation site [posttranslational modification] 713604007396 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 713604007397 HPr interaction site; other site 713604007398 glycerol kinase (GK) interaction site [polypeptide binding]; other site 713604007399 active site 713604007400 phosphorylation site [posttranslational modification] 713604007401 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604007402 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 713604007403 iron-sulfur cluster [ion binding]; other site 713604007404 [2Fe-2S] cluster binding site [ion binding]; other site 713604007405 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 713604007406 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604007407 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604007408 DNA binding residues [nucleotide binding] 713604007409 Putative zinc-finger; Region: zf-HC2; pfam13490 713604007410 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 713604007411 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 713604007412 Tetramer interface [polypeptide binding]; other site 713604007413 active site 713604007414 FMN-binding site [chemical binding]; other site 713604007415 shikimate kinase; Reviewed; Region: aroK; PRK00131 713604007416 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 713604007417 ADP binding site [chemical binding]; other site 713604007418 magnesium binding site [ion binding]; other site 713604007419 putative shikimate binding site; other site 713604007420 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 713604007421 active site 713604007422 dimer interface [polypeptide binding]; other site 713604007423 metal binding site [ion binding]; metal-binding site 713604007424 Dehydroquinase class II; Region: DHquinase_II; pfam01220 713604007425 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 713604007426 trimer interface [polypeptide binding]; other site 713604007427 active site 713604007428 dimer interface [polypeptide binding]; other site 713604007429 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604007430 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604007431 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 713604007432 putative dimer interface [polypeptide binding]; other site 713604007433 ligand binding site [chemical binding]; other site 713604007434 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 713604007435 active site 713604007436 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 713604007437 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 713604007438 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 713604007439 active site 713604007440 elongation factor P; Validated; Region: PRK00529 713604007441 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 713604007442 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 713604007443 RNA binding site [nucleotide binding]; other site 713604007444 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 713604007445 RNA binding site [nucleotide binding]; other site 713604007446 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 713604007447 putative RNA binding site [nucleotide binding]; other site 713604007448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604007449 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604007450 active site 713604007451 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604007452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604007453 non-specific DNA binding site [nucleotide binding]; other site 713604007454 salt bridge; other site 713604007455 sequence-specific DNA binding site [nucleotide binding]; other site 713604007456 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 713604007457 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 713604007458 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 713604007459 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 713604007460 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 713604007461 dihydroorotase; Validated; Region: pyrC; PRK09357 713604007462 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604007463 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 713604007464 active site 713604007465 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 713604007466 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 713604007467 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 713604007468 catalytic site [active] 713604007469 subunit interface [polypeptide binding]; other site 713604007470 Predicted ATPase [General function prediction only]; Region: COG4637 713604007471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604007472 Walker A/P-loop; other site 713604007473 ATP binding site [chemical binding]; other site 713604007474 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 713604007475 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 713604007476 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604007477 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 713604007478 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 713604007479 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604007480 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604007481 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 713604007482 IMP binding site; other site 713604007483 dimer interface [polypeptide binding]; other site 713604007484 interdomain contacts; other site 713604007485 partial ornithine binding site; other site 713604007486 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 713604007487 active site 713604007488 dimer interface [polypeptide binding]; other site 713604007489 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 713604007490 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 713604007491 catalytic site [active] 713604007492 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 713604007493 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 713604007494 Flavoprotein; Region: Flavoprotein; pfam02441 713604007495 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 713604007496 S-adenosylmethionine synthetase; Validated; Region: PRK05250 713604007497 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 713604007498 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 713604007499 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 713604007500 primosome assembly protein PriA; Provisional; Region: PRK14873 713604007501 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 713604007502 CotH protein; Region: CotH; pfam08757 713604007503 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 713604007504 putative substrate binding pocket [chemical binding]; other site 713604007505 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 713604007506 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 713604007507 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 713604007508 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 713604007509 putative active site [active] 713604007510 substrate binding site [chemical binding]; other site 713604007511 putative cosubstrate binding site; other site 713604007512 catalytic site [active] 713604007513 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 713604007514 substrate binding site [chemical binding]; other site 713604007515 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 713604007516 putative RNA binding site [nucleotide binding]; other site 713604007517 16S rRNA methyltransferase B; Provisional; Region: PRK14902 713604007518 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 713604007519 Flavoprotein; Region: Flavoprotein; cl08021 713604007520 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604007521 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604007522 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 713604007523 dimer interface [polypeptide binding]; other site 713604007524 Alkaline phosphatase homologues; Region: alkPPc; smart00098 713604007525 active site 713604007526 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604007527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604007528 active site 713604007529 phosphorylation site [posttranslational modification] 713604007530 intermolecular recognition site; other site 713604007531 dimerization interface [polypeptide binding]; other site 713604007532 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604007533 DNA binding residues [nucleotide binding] 713604007534 dimerization interface [polypeptide binding]; other site 713604007535 Histidine kinase; Region: HisKA_3; pfam07730 713604007536 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604007537 ATP binding site [chemical binding]; other site 713604007538 Mg2+ binding site [ion binding]; other site 713604007539 G-X-G motif; other site 713604007540 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 713604007541 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 713604007542 substrate binding site [chemical binding]; other site 713604007543 hexamer interface [polypeptide binding]; other site 713604007544 metal binding site [ion binding]; metal-binding site 713604007545 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 713604007546 Lumazine binding domain; Region: Lum_binding; pfam00677 713604007547 Lumazine binding domain; Region: Lum_binding; pfam00677 713604007548 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 713604007549 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 713604007550 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 713604007551 dimerization interface [polypeptide binding]; other site 713604007552 active site 713604007553 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 713604007554 homopentamer interface [polypeptide binding]; other site 713604007555 active site 713604007556 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 713604007557 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 713604007558 putative catalytic site [active] 713604007559 putative phosphate binding site [ion binding]; other site 713604007560 active site 713604007561 metal binding site A [ion binding]; metal-binding site 713604007562 DNA binding site [nucleotide binding] 713604007563 putative AP binding site [nucleotide binding]; other site 713604007564 putative metal binding site B [ion binding]; other site 713604007565 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604007566 cleavage site 713604007567 active site 713604007568 substrate binding sites [chemical binding]; other site 713604007569 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 713604007570 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 713604007571 active site 713604007572 GIY-YIG motif/motif A; other site 713604007573 catalytic site [active] 713604007574 putative DNA binding site [nucleotide binding]; other site 713604007575 metal binding site [ion binding]; metal-binding site 713604007576 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 713604007577 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 713604007578 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 713604007579 dimer interface [polypeptide binding]; other site 713604007580 phosphate binding site [ion binding]; other site 713604007581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 713604007582 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 713604007583 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 713604007584 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 713604007585 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 713604007586 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 713604007587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007589 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 713604007590 Ca binding site [ion binding]; other site 713604007591 Ca binding site (active) [ion binding]; other site 713604007592 ligand binding site [chemical binding]; other site 713604007593 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604007594 Interdomain contacts; other site 713604007595 Cytokine receptor motif; other site 713604007596 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604007597 Interdomain contacts; other site 713604007598 Cytokine receptor motif; other site 713604007599 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604007600 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604007601 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 713604007602 substrate binding site [chemical binding]; other site 713604007603 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 713604007604 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 713604007605 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604007606 MAEBL; Provisional; Region: PTZ00121 713604007607 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 713604007608 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604007609 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604007610 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604007611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604007612 dimerization interface [polypeptide binding]; other site 713604007613 putative DNA binding site [nucleotide binding]; other site 713604007614 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604007615 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604007616 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 713604007617 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 713604007618 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 713604007619 Phosphoglycerate kinase; Region: PGK; pfam00162 713604007620 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 713604007621 substrate binding site [chemical binding]; other site 713604007622 hinge regions; other site 713604007623 ADP binding site [chemical binding]; other site 713604007624 catalytic site [active] 713604007625 triosephosphate isomerase; Provisional; Region: PRK14567 713604007626 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 713604007627 substrate binding site [chemical binding]; other site 713604007628 dimer interface [polypeptide binding]; other site 713604007629 catalytic triad [active] 713604007630 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 713604007631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604007632 Histidine kinase; Region: HisKA_3; pfam07730 713604007633 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604007634 ATP binding site [chemical binding]; other site 713604007635 Mg2+ binding site [ion binding]; other site 713604007636 G-X-G motif; other site 713604007637 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 713604007638 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 713604007639 putative active site [active] 713604007640 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 713604007641 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 713604007642 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 713604007643 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 713604007644 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 713604007645 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 713604007646 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 713604007647 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 713604007648 putative active site [active] 713604007649 transaldolase; Provisional; Region: PRK03903 713604007650 catalytic residue [active] 713604007651 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 713604007652 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 713604007653 TPP-binding site [chemical binding]; other site 713604007654 dimer interface [polypeptide binding]; other site 713604007655 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 713604007656 PYR/PP interface [polypeptide binding]; other site 713604007657 dimer interface [polypeptide binding]; other site 713604007658 TPP binding site [chemical binding]; other site 713604007659 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604007660 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 713604007661 UbiA prenyltransferase family; Region: UbiA; pfam01040 713604007662 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 713604007663 Part of AAA domain; Region: AAA_19; pfam13245 713604007664 Family description; Region: UvrD_C_2; pfam13538 713604007665 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 713604007666 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 713604007667 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 713604007668 NADP binding site [chemical binding]; other site 713604007669 dimer interface [polypeptide binding]; other site 713604007670 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 713604007671 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604007672 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604007673 Di-iron ligands [ion binding]; other site 713604007674 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 713604007675 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 713604007676 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604007677 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604007678 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604007679 Walker A/P-loop; other site 713604007680 ATP binding site [chemical binding]; other site 713604007681 Q-loop/lid; other site 713604007682 ABC transporter signature motif; other site 713604007683 Walker B; other site 713604007684 D-loop; other site 713604007685 H-loop/switch region; other site 713604007686 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 713604007687 Predicted transcriptional regulator [Transcription]; Region: COG2345 713604007688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604007689 putative DNA binding site [nucleotide binding]; other site 713604007690 putative Zn2+ binding site [ion binding]; other site 713604007691 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 713604007692 FeS assembly protein SufB; Region: sufB; TIGR01980 713604007693 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 713604007694 FeS assembly protein SufD; Region: sufD; TIGR01981 713604007695 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 713604007696 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 713604007697 Walker A/P-loop; other site 713604007698 ATP binding site [chemical binding]; other site 713604007699 Q-loop/lid; other site 713604007700 ABC transporter signature motif; other site 713604007701 Walker B; other site 713604007702 D-loop; other site 713604007703 H-loop/switch region; other site 713604007704 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604007705 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 713604007706 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604007707 catalytic residue [active] 713604007708 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 713604007709 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 713604007710 trimerization site [polypeptide binding]; other site 713604007711 active site 713604007712 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 713604007713 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 713604007714 hypothetical protein; Provisional; Region: PRK02237 713604007715 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 713604007716 ABC1 family; Region: ABC1; cl17513 713604007717 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 713604007718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604007719 Histidine kinase; Region: HisKA_3; pfam07730 713604007720 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604007721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604007722 active site 713604007723 phosphorylation site [posttranslational modification] 713604007724 intermolecular recognition site; other site 713604007725 dimerization interface [polypeptide binding]; other site 713604007726 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604007727 DNA binding residues [nucleotide binding] 713604007728 dimerization interface [polypeptide binding]; other site 713604007729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604007730 S-adenosylmethionine binding site [chemical binding]; other site 713604007731 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 713604007732 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 713604007733 CysD dimerization site [polypeptide binding]; other site 713604007734 G1 box; other site 713604007735 putative GEF interaction site [polypeptide binding]; other site 713604007736 GTP/Mg2+ binding site [chemical binding]; other site 713604007737 Switch I region; other site 713604007738 G2 box; other site 713604007739 G3 box; other site 713604007740 Switch II region; other site 713604007741 G4 box; other site 713604007742 G5 box; other site 713604007743 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 713604007744 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 713604007745 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 713604007746 ligand-binding site [chemical binding]; other site 713604007747 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 713604007748 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 713604007749 Active Sites [active] 713604007750 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604007751 short chain dehydrogenase; Provisional; Region: PRK07890 713604007752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604007753 NAD(P) binding site [chemical binding]; other site 713604007754 active site 713604007755 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 713604007756 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604007757 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604007758 active site 713604007759 TDP-binding site; other site 713604007760 acceptor substrate-binding pocket; other site 713604007761 homodimer interface [polypeptide binding]; other site 713604007762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007763 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604007764 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604007765 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604007766 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604007767 metal binding site [ion binding]; metal-binding site 713604007768 active site 713604007769 I-site; other site 713604007770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604007771 dimerization interface [polypeptide binding]; other site 713604007772 putative DNA binding site [nucleotide binding]; other site 713604007773 putative Zn2+ binding site [ion binding]; other site 713604007774 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 713604007775 putative hydrophobic ligand binding site [chemical binding]; other site 713604007776 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 713604007777 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 713604007778 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604007779 Zn2+ binding site [ion binding]; other site 713604007780 Mg2+ binding site [ion binding]; other site 713604007781 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 713604007782 putative active site [active] 713604007783 putative catalytic triad [active] 713604007784 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 713604007785 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 713604007786 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 713604007787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604007788 Walker A/P-loop; other site 713604007789 ATP binding site [chemical binding]; other site 713604007790 Q-loop/lid; other site 713604007791 ABC transporter signature motif; other site 713604007792 Walker B; other site 713604007793 D-loop; other site 713604007794 H-loop/switch region; other site 713604007795 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604007796 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604007797 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604007798 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604007799 MarR family; Region: MarR_2; pfam12802 713604007800 MarR family; Region: MarR_2; cl17246 713604007801 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604007802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604007803 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604007804 Walker A/P-loop; other site 713604007805 ATP binding site [chemical binding]; other site 713604007806 Q-loop/lid; other site 713604007807 ABC transporter signature motif; other site 713604007808 Walker B; other site 713604007809 D-loop; other site 713604007810 H-loop/switch region; other site 713604007811 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604007812 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604007813 hypothetical protein; Provisional; Region: PRK02947 713604007814 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 713604007815 putative active site [active] 713604007816 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604007817 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 713604007818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604007819 S-adenosylmethionine binding site [chemical binding]; other site 713604007820 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604007821 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604007822 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604007823 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 713604007824 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 713604007825 catalytic triad [active] 713604007826 PAS fold; Region: PAS_4; pfam08448 713604007827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604007828 putative active site [active] 713604007829 heme pocket [chemical binding]; other site 713604007830 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604007831 metal binding site [ion binding]; metal-binding site 713604007832 active site 713604007833 I-site; other site 713604007834 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604007835 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604007836 Cytochrome P450; Region: p450; cl12078 713604007837 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604007838 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604007839 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604007840 nudix motif; other site 713604007841 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 713604007842 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 713604007843 dimer interface [polypeptide binding]; other site 713604007844 putative radical transfer pathway; other site 713604007845 diiron center [ion binding]; other site 713604007846 tyrosyl radical; other site 713604007847 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 713604007848 ATP cone domain; Region: ATP-cone; pfam03477 713604007849 Class I ribonucleotide reductase; Region: RNR_I; cd01679 713604007850 active site 713604007851 dimer interface [polypeptide binding]; other site 713604007852 catalytic residues [active] 713604007853 effector binding site; other site 713604007854 R2 peptide binding site; other site 713604007855 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 713604007856 enoyl-CoA hydratase; Provisional; Region: PRK08260 713604007857 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604007858 substrate binding site [chemical binding]; other site 713604007859 oxyanion hole (OAH) forming residues; other site 713604007860 trimer interface [polypeptide binding]; other site 713604007861 HEAT repeats; Region: HEAT_2; pfam13646 713604007862 TIGR03084 family protein; Region: TIGR03084 713604007863 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604007864 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 713604007865 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604007866 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604007867 active site 713604007868 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 713604007869 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 713604007870 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 713604007871 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604007872 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604007873 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 713604007874 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604007875 carboxyltransferase (CT) interaction site; other site 713604007876 biotinylation site [posttranslational modification]; other site 713604007877 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604007878 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604007879 active site 713604007880 short chain dehydrogenase; Provisional; Region: PRK08278 713604007881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604007882 NAD(P) binding site [chemical binding]; other site 713604007883 active site 713604007884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007886 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 713604007887 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 713604007888 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 713604007889 active site 713604007890 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604007891 metal binding site [ion binding]; metal-binding site 713604007892 active site 713604007893 I-site; other site 713604007894 oxidase reductase; Provisional; Region: PTZ00273 713604007895 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 713604007896 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 713604007897 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 713604007898 nucleoside/Zn binding site; other site 713604007899 dimer interface [polypeptide binding]; other site 713604007900 catalytic motif [active] 713604007901 WYL domain; Region: WYL; pfam13280 713604007902 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604007903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007905 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 713604007906 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 713604007907 dimer interface [polypeptide binding]; other site 713604007908 active site 713604007909 CoA binding pocket [chemical binding]; other site 713604007910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007912 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604007913 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604007914 putative sugar binding sites [chemical binding]; other site 713604007915 Q-X-W motif; other site 713604007916 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 713604007917 active site 713604007918 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604007919 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604007920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007921 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604007922 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604007923 DNA binding residues [nucleotide binding] 713604007924 dimer interface [polypeptide binding]; other site 713604007925 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604007926 Helix-turn-helix domain; Region: HTH_31; pfam13560 713604007927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604007928 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604007929 Walker A/P-loop; other site 713604007930 ATP binding site [chemical binding]; other site 713604007931 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 713604007932 structural tetrad; other site 713604007933 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604007934 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 713604007935 structural tetrad; other site 713604007936 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 713604007937 hypothetical protein; Provisional; Region: PRK07236 713604007938 hypothetical protein; Provisional; Region: PRK06834 713604007939 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604007940 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604007941 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604007942 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604007943 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604007944 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604007945 AsnC family; Region: AsnC_trans_reg; pfam01037 713604007946 CHAT domain; Region: CHAT; pfam12770 713604007947 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604007948 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604007949 MarR family; Region: MarR_2; pfam12802 713604007950 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604007951 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604007952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604007953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604007954 active site 713604007955 phosphorylation site [posttranslational modification] 713604007956 intermolecular recognition site; other site 713604007957 dimerization interface [polypeptide binding]; other site 713604007958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604007959 DNA binding residues [nucleotide binding] 713604007960 dimerization interface [polypeptide binding]; other site 713604007961 Histidine kinase; Region: HisKA_3; pfam07730 713604007962 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604007963 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 713604007964 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604007965 active site 713604007966 catalytic residues [active] 713604007967 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604007968 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604007969 dimerization interface [polypeptide binding]; other site 713604007970 ligand binding site [chemical binding]; other site 713604007971 4Fe-4S binding domain; Region: Fer4; pfam00037 713604007972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604007973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604007975 short chain dehydrogenase; Provisional; Region: PRK08263 713604007976 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604007977 NADP binding site [chemical binding]; other site 713604007978 active site 713604007979 steroid binding site; other site 713604007980 OsmC-like protein; Region: OsmC; cl00767 713604007981 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604007982 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604007983 putative Zn2+ binding site [ion binding]; other site 713604007984 putative DNA binding site [nucleotide binding]; other site 713604007985 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604007986 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 713604007987 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 713604007988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604007989 S-adenosylmethionine binding site [chemical binding]; other site 713604007990 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 713604007991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604007992 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 713604007993 RNA polymerase sigma factor; Provisional; Region: PRK12537 713604007994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604007995 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604007996 DNA binding residues [nucleotide binding] 713604007997 cell division protein FtsZ; Validated; Region: PRK09330 713604007998 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 713604007999 nucleotide binding site [chemical binding]; other site 713604008000 SulA interaction site; other site 713604008001 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 713604008002 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 713604008003 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 713604008004 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604008005 catalytic residue [active] 713604008006 Protein of unknown function (DUF552); Region: DUF552; pfam04472 713604008007 Predicted integral membrane protein [Function unknown]; Region: COG0762 713604008008 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604008009 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 713604008010 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 713604008011 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604008012 putative DNA binding site [nucleotide binding]; other site 713604008013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604008015 putative substrate translocation pore; other site 713604008016 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 713604008017 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 713604008018 HIGH motif; other site 713604008019 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 713604008020 active site 713604008021 KMSKS motif; other site 713604008022 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 713604008023 tRNA binding surface [nucleotide binding]; other site 713604008024 anticodon binding site; other site 713604008025 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 713604008026 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604008027 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604008028 dimerization interface [polypeptide binding]; other site 713604008029 putative DNA binding site [nucleotide binding]; other site 713604008030 putative Zn2+ binding site [ion binding]; other site 713604008031 potassium/proton antiporter; Reviewed; Region: PRK05326 713604008032 TrkA-C domain; Region: TrkA_C; pfam02080 713604008033 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604008034 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604008035 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604008036 catalytic residue [active] 713604008037 lipoprotein signal peptidase; Provisional; Region: PRK14764 713604008038 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 713604008039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 713604008040 RNA binding surface [nucleotide binding]; other site 713604008041 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 713604008042 active site 713604008043 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 713604008044 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 713604008045 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 713604008046 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 713604008047 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 713604008048 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 713604008049 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604008050 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 713604008051 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604008052 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 713604008053 active site 713604008054 catalytic site [active] 713604008055 exopolyphosphatase; Region: exo_poly_only; TIGR03706 713604008056 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 713604008057 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 713604008058 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 713604008059 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 713604008060 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 713604008061 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 713604008062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604008063 motif II; other site 713604008064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604008065 dimerization interface [polypeptide binding]; other site 713604008066 putative DNA binding site [nucleotide binding]; other site 713604008067 putative Zn2+ binding site [ion binding]; other site 713604008068 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604008069 CoenzymeA binding site [chemical binding]; other site 713604008070 subunit interaction site [polypeptide binding]; other site 713604008071 PHB binding site; other site 713604008072 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604008073 MarR family; Region: MarR_2; pfam12802 713604008074 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604008075 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604008076 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604008077 nucleotide binding site [chemical binding]; other site 713604008078 Butyrate kinase [Energy production and conversion]; Region: COG3426 713604008079 Domain of unknown function (DUF427); Region: DUF427; pfam04248 713604008080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 713604008081 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 713604008082 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 713604008083 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604008084 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604008085 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 713604008086 Predicted integral membrane protein [Function unknown]; Region: COG5660 713604008087 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 713604008088 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604008089 DNA binding residues [nucleotide binding] 713604008090 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604008091 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604008092 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604008093 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604008094 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604008095 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 713604008096 catalytic loop [active] 713604008097 iron binding site [ion binding]; other site 713604008098 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604008099 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604008100 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 713604008101 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604008102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008104 short chain dehydrogenase; Provisional; Region: PRK08263 713604008105 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604008106 NADP binding site [chemical binding]; other site 713604008107 active site 713604008108 steroid binding site; other site 713604008109 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604008110 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604008111 active site 713604008112 catalytic tetrad [active] 713604008113 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604008114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604008115 Walker A motif; other site 713604008116 ATP binding site [chemical binding]; other site 713604008117 Walker B motif; other site 713604008118 arginine finger; other site 713604008119 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604008120 metal ion-dependent adhesion site (MIDAS); other site 713604008121 adenosine deaminase; Provisional; Region: PRK09358 713604008122 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 713604008123 active site 713604008124 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 713604008125 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 713604008126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604008127 ATP binding site [chemical binding]; other site 713604008128 putative Mg++ binding site [ion binding]; other site 713604008129 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604008130 nucleotide binding region [chemical binding]; other site 713604008131 ATP-binding site [chemical binding]; other site 713604008132 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 713604008133 HRDC domain; Region: HRDC; pfam00570 713604008134 short chain dehydrogenase; Provisional; Region: PRK12937 713604008135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604008136 NAD(P) binding site [chemical binding]; other site 713604008137 active site 713604008138 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604008139 DinB superfamily; Region: DinB_2; pfam12867 713604008140 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 713604008141 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 713604008142 DNA binding residues [nucleotide binding] 713604008143 dimer interface [polypeptide binding]; other site 713604008144 [2Fe-2S] cluster binding site [ion binding]; other site 713604008145 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604008146 Predicted flavoprotein [General function prediction only]; Region: COG0431 713604008147 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604008148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604008149 dimerization interface [polypeptide binding]; other site 713604008150 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604008151 dimer interface [polypeptide binding]; other site 713604008152 phosphorylation site [posttranslational modification] 713604008153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604008154 ATP binding site [chemical binding]; other site 713604008155 Mg2+ binding site [ion binding]; other site 713604008156 G-X-G motif; other site 713604008157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604008158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604008159 active site 713604008160 phosphorylation site [posttranslational modification] 713604008161 intermolecular recognition site; other site 713604008162 dimerization interface [polypeptide binding]; other site 713604008163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604008164 DNA binding site [nucleotide binding] 713604008165 PAP2 superfamily; Region: PAP2; pfam01569 713604008166 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 713604008167 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604008168 catalytic residue [active] 713604008169 hypothetical protein; Provisional; Region: PRK08266 713604008170 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604008171 PYR/PP interface [polypeptide binding]; other site 713604008172 dimer interface [polypeptide binding]; other site 713604008173 TPP binding site [chemical binding]; other site 713604008174 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604008175 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 713604008176 TPP-binding site [chemical binding]; other site 713604008177 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604008178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 713604008179 DNA-binding site [nucleotide binding]; DNA binding site 713604008180 FCD domain; Region: FCD; pfam07729 713604008181 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604008182 Pirin-related protein [General function prediction only]; Region: COG1741 713604008183 Pirin; Region: Pirin; pfam02678 713604008184 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 713604008185 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 713604008186 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 713604008187 dimer interface [polypeptide binding]; other site 713604008188 ssDNA binding site [nucleotide binding]; other site 713604008189 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604008190 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604008191 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 713604008192 Transglycosylase; Region: Transgly; pfam00912 713604008193 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604008194 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604008195 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604008196 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604008197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604008198 Q-loop/lid; other site 713604008199 ABC transporter signature motif; other site 713604008200 Walker B; other site 713604008201 D-loop; other site 713604008202 H-loop/switch region; other site 713604008203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604008204 Walker A/P-loop; other site 713604008205 ATP binding site [chemical binding]; other site 713604008206 MarR family; Region: MarR_2; cl17246 713604008207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604008208 dimerization interface [polypeptide binding]; other site 713604008209 putative DNA binding site [nucleotide binding]; other site 713604008210 putative Zn2+ binding site [ion binding]; other site 713604008211 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 713604008212 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 713604008213 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 713604008214 putative NAD(P) binding site [chemical binding]; other site 713604008215 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604008216 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 713604008217 dimer interface [polypeptide binding]; other site 713604008218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604008219 Coenzyme A binding pocket [chemical binding]; other site 713604008220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604008221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604008222 ATP binding site [chemical binding]; other site 713604008223 Mg2+ binding site [ion binding]; other site 713604008224 G-X-G motif; other site 713604008225 Carboxylesterase family; Region: COesterase; pfam00135 713604008226 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604008227 substrate binding pocket [chemical binding]; other site 713604008228 catalytic triad [active] 713604008229 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604008230 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604008231 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604008232 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604008233 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 713604008234 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604008235 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604008236 catalytic loop [active] 713604008237 iron binding site [ion binding]; other site 713604008238 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604008239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008241 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 713604008242 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 713604008243 tetrameric interface [polypeptide binding]; other site 713604008244 NAD binding site [chemical binding]; other site 713604008245 catalytic residues [active] 713604008246 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604008247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604008248 DNA-binding site [nucleotide binding]; DNA binding site 713604008249 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 713604008250 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 713604008251 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604008252 NAD binding site [chemical binding]; other site 713604008253 catalytic Zn binding site [ion binding]; other site 713604008254 structural Zn binding site [ion binding]; other site 713604008255 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604008256 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 713604008257 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 713604008258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604008259 ATP binding site [chemical binding]; other site 713604008260 Mg2+ binding site [ion binding]; other site 713604008261 G-X-G motif; other site 713604008262 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 713604008263 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 713604008264 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 713604008265 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604008266 MarR family; Region: MarR; pfam01047 713604008267 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604008268 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 713604008269 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 713604008270 putative dimer interface [polypeptide binding]; other site 713604008271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604008272 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604008273 NAD(P) binding site [chemical binding]; other site 713604008274 active site 713604008275 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 713604008276 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 713604008277 D-pathway; other site 713604008278 Putative ubiquinol binding site [chemical binding]; other site 713604008279 Low-spin heme (heme b) binding site [chemical binding]; other site 713604008280 Putative water exit pathway; other site 713604008281 Binuclear center (heme o3/CuB) [ion binding]; other site 713604008282 K-pathway; other site 713604008283 Putative proton exit pathway; other site 713604008284 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 713604008285 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 713604008286 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 713604008287 active site 713604008288 catalytic site [active] 713604008289 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 713604008290 dimanganese center [ion binding]; other site 713604008291 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604008292 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 713604008293 NADP binding site [chemical binding]; other site 713604008294 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604008295 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604008296 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604008297 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 713604008298 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604008299 active site 713604008300 catalytic triad [active] 713604008301 oxyanion hole [active] 713604008302 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604008303 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604008304 DNA binding site [nucleotide binding] 713604008305 domain linker motif; other site 713604008306 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604008307 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604008308 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604008309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008310 dimer interface [polypeptide binding]; other site 713604008311 conserved gate region; other site 713604008312 putative PBP binding loops; other site 713604008313 ABC-ATPase subunit interface; other site 713604008314 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604008315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008316 dimer interface [polypeptide binding]; other site 713604008317 conserved gate region; other site 713604008318 putative PBP binding loops; other site 713604008319 ABC-ATPase subunit interface; other site 713604008320 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 713604008321 legume lectins; Region: lectin_L-type; cl14058 713604008322 homotetramer interaction site [polypeptide binding]; other site 713604008323 hypothetical protein; Provisional; Region: PRK06215 713604008324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008325 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604008326 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604008327 active site 713604008328 catalytic tetrad [active] 713604008329 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604008330 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604008331 conserved cys residue [active] 713604008332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604008333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604008334 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604008335 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604008336 active site 713604008337 catalytic tetrad [active] 713604008338 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 713604008339 dimer interface [polypeptide binding]; other site 713604008340 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604008341 HTH domain; Region: HTH_11; pfam08279 713604008342 WYL domain; Region: WYL; pfam13280 713604008343 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 713604008344 Ligand Binding Site [chemical binding]; other site 713604008345 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 713604008346 AIR carboxylase; Region: AIRC; smart01001 713604008347 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 713604008348 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 713604008349 Amidohydrolase; Region: Amidohydro_2; pfam04909 713604008350 active site 713604008351 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604008352 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604008353 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 713604008354 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604008355 metal binding site [ion binding]; metal-binding site 713604008356 substrate binding pocket [chemical binding]; other site 713604008357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604008358 classical (c) SDRs; Region: SDR_c; cd05233 713604008359 NAD(P) binding site [chemical binding]; other site 713604008360 active site 713604008361 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 713604008362 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604008363 ligand binding site [chemical binding]; other site 713604008364 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 713604008365 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604008366 Walker A/P-loop; other site 713604008367 ATP binding site [chemical binding]; other site 713604008368 Q-loop/lid; other site 713604008369 ABC transporter signature motif; other site 713604008370 Walker B; other site 713604008371 D-loop; other site 713604008372 H-loop/switch region; other site 713604008373 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604008374 ABC transporter; Region: ABC_tran; pfam00005 713604008375 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604008376 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604008377 TM-ABC transporter signature motif; other site 713604008378 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604008379 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604008380 active site 713604008381 catalytic tetrad [active] 713604008382 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 713604008383 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 713604008384 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604008385 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604008386 putative sugar binding sites [chemical binding]; other site 713604008387 Q-X-W motif; other site 713604008388 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604008389 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604008390 DNA-binding site [nucleotide binding]; DNA binding site 713604008391 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604008392 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604008393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008394 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604008395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604008396 DNA binding site [nucleotide binding] 713604008397 domain linker motif; other site 713604008398 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604008399 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 713604008400 ligand binding site [chemical binding]; other site 713604008401 dimerization interface (open form) [polypeptide binding]; other site 713604008402 dimerization interface (closed form) [polypeptide binding]; other site 713604008403 acyl-CoA synthetase; Validated; Region: PRK07788 713604008404 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008405 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604008406 putative AMP binding site [chemical binding]; other site 713604008407 putative active site [active] 713604008408 acyl-activating enzyme (AAE) consensus motif; other site 713604008409 putative CoA binding site [chemical binding]; other site 713604008410 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604008411 Lsr2; Region: Lsr2; pfam11774 713604008412 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008413 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604008414 acyl-activating enzyme (AAE) consensus motif; other site 713604008415 AMP binding site [chemical binding]; other site 713604008416 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008417 Condensation domain; Region: Condensation; pfam00668 713604008418 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008419 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008420 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008421 acyl-activating enzyme (AAE) consensus motif; other site 713604008422 AMP binding site [chemical binding]; other site 713604008423 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008424 Condensation domain; Region: Condensation; pfam00668 713604008425 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008426 Condensation domain; Region: Condensation; pfam00668 713604008427 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008428 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008429 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 713604008430 acyl-activating enzyme (AAE) consensus motif; other site 713604008431 AMP binding site [chemical binding]; other site 713604008432 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008433 Condensation domain; Region: Condensation; pfam00668 713604008434 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008435 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008436 Condensation domain; Region: Condensation; pfam00668 713604008437 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008438 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008439 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008440 acyl-activating enzyme (AAE) consensus motif; other site 713604008441 AMP binding site [chemical binding]; other site 713604008442 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008443 Condensation domain; Region: Condensation; pfam00668 713604008444 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008445 Condensation domain; Region: Condensation; pfam00668 713604008446 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008447 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008448 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008449 acyl-activating enzyme (AAE) consensus motif; other site 713604008450 AMP binding site [chemical binding]; other site 713604008451 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008452 MbtH-like protein; Region: MbtH; cl01279 713604008453 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604008454 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604008455 peptide synthase; Provisional; Region: PRK12316 713604008456 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008457 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008458 acyl-activating enzyme (AAE) consensus motif; other site 713604008459 AMP binding site [chemical binding]; other site 713604008460 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008461 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008462 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008463 acyl-activating enzyme (AAE) consensus motif; other site 713604008464 AMP binding site [chemical binding]; other site 713604008465 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008466 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008467 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008468 acyl-activating enzyme (AAE) consensus motif; other site 713604008469 AMP binding site [chemical binding]; other site 713604008470 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008471 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008472 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008473 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008474 acyl-activating enzyme (AAE) consensus motif; other site 713604008475 AMP binding site [chemical binding]; other site 713604008476 active site 713604008477 CoA binding site [chemical binding]; other site 713604008478 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008479 Condensation domain; Region: Condensation; pfam00668 713604008480 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604008481 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604008482 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008483 acyl-activating enzyme (AAE) consensus motif; other site 713604008484 AMP binding site [chemical binding]; other site 713604008485 active site 713604008486 CoA binding site [chemical binding]; other site 713604008487 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604008488 Condensation domain; Region: Condensation; pfam00668 713604008489 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604008490 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604008491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008492 putative substrate translocation pore; other site 713604008493 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604008494 Cytochrome P450; Region: p450; cl12078 713604008495 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604008496 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604008497 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604008498 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604008499 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604008500 putative NAD(P) binding site [chemical binding]; other site 713604008501 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604008502 Zn2+ binding site [ion binding]; other site 713604008503 Mg2+ binding site [ion binding]; other site 713604008504 Chitin binding domain; Region: Chitin_bind_3; pfam03067 713604008505 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604008506 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 713604008507 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 713604008508 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 713604008509 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604008510 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604008511 DNA binding residues [nucleotide binding] 713604008512 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 713604008513 putative hydrophobic ligand binding site [chemical binding]; other site 713604008514 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604008515 anti sigma factor interaction site; other site 713604008516 regulatory phosphorylation site [posttranslational modification]; other site 713604008517 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 713604008518 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604008519 active site 713604008520 metal binding site [ion binding]; metal-binding site 713604008521 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 713604008522 active site 713604008523 catalytic triad [active] 713604008524 oxyanion hole [active] 713604008525 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604008526 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604008527 NAD(P) binding site [chemical binding]; other site 713604008528 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 713604008529 classical (c) SDRs; Region: SDR_c; cd05233 713604008530 NAD(P) binding site [chemical binding]; other site 713604008531 active site 713604008532 classical (c) SDRs; Region: SDR_c; cd05233 713604008533 NAD(P) binding site [chemical binding]; other site 713604008534 active site 713604008535 RibD C-terminal domain; Region: RibD_C; cl17279 713604008536 enoyl-CoA hydratase; Provisional; Region: PRK06210 713604008537 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604008538 substrate binding site [chemical binding]; other site 713604008539 oxyanion hole (OAH) forming residues; other site 713604008540 trimer interface [polypeptide binding]; other site 713604008541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 713604008542 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604008543 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604008544 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604008545 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604008546 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008547 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008548 acyl-activating enzyme (AAE) consensus motif; other site 713604008549 AMP binding site [chemical binding]; other site 713604008550 active site 713604008551 CoA binding site [chemical binding]; other site 713604008552 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 713604008553 active site 713604008554 substrate binding pocket [chemical binding]; other site 713604008555 homodimer interaction site [polypeptide binding]; other site 713604008556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008558 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604008559 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604008560 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604008561 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 713604008562 active site 713604008563 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604008564 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 713604008565 active site 713604008566 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604008567 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 713604008568 FAD binding site [chemical binding]; other site 713604008569 substrate binding site [chemical binding]; other site 713604008570 catalytic base [active] 713604008571 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 713604008572 putative active site [active] 713604008573 putative substrate binding site [chemical binding]; other site 713604008574 ATP binding site [chemical binding]; other site 713604008575 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 713604008576 putative active site [active] 713604008577 putative catalytic site [active] 713604008578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604008579 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 713604008580 NAD(P) binding site [chemical binding]; other site 713604008581 active site 713604008582 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 713604008583 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604008584 active site pocket [active] 713604008585 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604008586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604008587 DNA-binding site [nucleotide binding]; DNA binding site 713604008588 FCD domain; Region: FCD; pfam07729 713604008589 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604008590 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604008591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008592 dimer interface [polypeptide binding]; other site 713604008593 conserved gate region; other site 713604008594 putative PBP binding loops; other site 713604008595 ABC-ATPase subunit interface; other site 713604008596 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604008597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008598 dimer interface [polypeptide binding]; other site 713604008599 conserved gate region; other site 713604008600 putative PBP binding loops; other site 713604008601 ABC-ATPase subunit interface; other site 713604008602 hypothetical protein; Validated; Region: PRK08245 713604008603 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604008604 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604008605 active site 713604008606 ATP binding site [chemical binding]; other site 713604008607 substrate binding site [chemical binding]; other site 713604008608 activation loop (A-loop); other site 713604008609 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 713604008610 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604008611 DNA binding site [nucleotide binding] 713604008612 UbiA prenyltransferase family; Region: UbiA; pfam01040 713604008613 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 713604008614 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604008615 Histidine kinase; Region: HisKA_3; pfam07730 713604008616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604008617 ATP binding site [chemical binding]; other site 713604008618 Mg2+ binding site [ion binding]; other site 713604008619 G-X-G motif; other site 713604008620 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604008621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604008622 active site 713604008623 phosphorylation site [posttranslational modification] 713604008624 intermolecular recognition site; other site 713604008625 dimerization interface [polypeptide binding]; other site 713604008626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604008627 DNA binding residues [nucleotide binding] 713604008628 dimerization interface [polypeptide binding]; other site 713604008629 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604008630 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 713604008631 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604008632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008633 putative substrate translocation pore; other site 713604008634 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 713604008635 Zn binding site [ion binding]; other site 713604008636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604008637 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604008638 dimerization interface [polypeptide binding]; other site 713604008639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604008640 dimer interface [polypeptide binding]; other site 713604008641 phosphorylation site [posttranslational modification] 713604008642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604008643 ATP binding site [chemical binding]; other site 713604008644 Mg2+ binding site [ion binding]; other site 713604008645 G-X-G motif; other site 713604008646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604008647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604008648 active site 713604008649 phosphorylation site [posttranslational modification] 713604008650 intermolecular recognition site; other site 713604008651 dimerization interface [polypeptide binding]; other site 713604008652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604008653 DNA binding site [nucleotide binding] 713604008654 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604008655 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604008656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604008657 Walker A/P-loop; other site 713604008658 ATP binding site [chemical binding]; other site 713604008659 Q-loop/lid; other site 713604008660 ABC transporter signature motif; other site 713604008661 Walker B; other site 713604008662 D-loop; other site 713604008663 H-loop/switch region; other site 713604008664 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604008665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604008666 NAD(P) binding site [chemical binding]; other site 713604008667 active site 713604008668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008670 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604008671 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604008672 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604008673 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604008674 Walker A/P-loop; other site 713604008675 ATP binding site [chemical binding]; other site 713604008676 Q-loop/lid; other site 713604008677 ABC transporter signature motif; other site 713604008678 Walker B; other site 713604008679 D-loop; other site 713604008680 H-loop/switch region; other site 713604008681 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 713604008682 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 713604008683 nucleotide binding pocket [chemical binding]; other site 713604008684 K-X-D-G motif; other site 713604008685 catalytic site [active] 713604008686 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 713604008687 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 713604008688 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604008689 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604008690 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 713604008691 catalytic residues [active] 713604008692 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 713604008693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604008694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604008695 DNA binding residues [nucleotide binding] 713604008696 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 713604008697 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604008698 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604008699 HTH domain; Region: HTH_11; pfam08279 713604008700 WYL domain; Region: WYL; pfam13280 713604008701 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604008702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008703 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 713604008704 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 713604008705 tetramer interface [polypeptide binding]; other site 713604008706 active site 713604008707 Mg2+/Mn2+ binding site [ion binding]; other site 713604008708 TIGR03086 family protein; Region: TIGR03086 713604008709 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604008710 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604008711 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604008712 DNA binding residues [nucleotide binding] 713604008713 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 713604008714 MarR family; Region: MarR_2; pfam12802 713604008715 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 713604008716 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 713604008717 active site 713604008718 catalytic site [active] 713604008719 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 713604008720 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 713604008721 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 713604008722 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604008723 putative ligand binding site [chemical binding]; other site 713604008724 putative NAD binding site [chemical binding]; other site 713604008725 catalytic site [active] 713604008726 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604008727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008728 dimer interface [polypeptide binding]; other site 713604008729 conserved gate region; other site 713604008730 putative PBP binding loops; other site 713604008731 ABC-ATPase subunit interface; other site 713604008732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008733 dimer interface [polypeptide binding]; other site 713604008734 conserved gate region; other site 713604008735 putative PBP binding loops; other site 713604008736 ABC-ATPase subunit interface; other site 713604008737 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604008738 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604008739 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 713604008740 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604008741 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604008742 dimerization interface [polypeptide binding]; other site 713604008743 ligand binding site [chemical binding]; other site 713604008744 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604008745 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604008746 active site 713604008747 ATP binding site [chemical binding]; other site 713604008748 substrate binding site [chemical binding]; other site 713604008749 activation loop (A-loop); other site 713604008750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604008751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604008752 DNA binding site [nucleotide binding] 713604008753 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604008754 dimerization interface [polypeptide binding]; other site 713604008755 ligand binding site [chemical binding]; other site 713604008756 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604008757 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604008758 active site 713604008759 ATP binding site [chemical binding]; other site 713604008760 substrate binding site [chemical binding]; other site 713604008761 activation loop (A-loop); other site 713604008762 Cellulose binding domain; Region: CBM_2; pfam00553 713604008763 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604008764 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604008765 active site 713604008766 ATP binding site [chemical binding]; other site 713604008767 substrate binding site [chemical binding]; other site 713604008768 activation loop (A-loop); other site 713604008769 Cellulose binding domain; Region: CBM_2; pfam00553 713604008770 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604008771 anti sigma factor interaction site; other site 713604008772 regulatory phosphorylation site [posttranslational modification]; other site 713604008773 Polysulphide reductase, NrfD; Region: NrfD; cl01295 713604008774 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 713604008775 4Fe-4S binding domain; Region: Fer4_6; pfam12837 713604008776 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 713604008777 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604008778 molybdopterin cofactor binding site; other site 713604008779 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604008780 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604008781 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 713604008782 molybdopterin cofactor binding site; other site 713604008783 benzoate transport; Region: 2A0115; TIGR00895 713604008784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008785 putative substrate translocation pore; other site 713604008786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604008787 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604008788 anti sigma factor interaction site; other site 713604008789 regulatory phosphorylation site [posttranslational modification]; other site 713604008790 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604008791 DinB superfamily; Region: DinB_2; pfam12867 713604008792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604008793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604008794 non-specific DNA binding site [nucleotide binding]; other site 713604008795 salt bridge; other site 713604008796 sequence-specific DNA binding site [nucleotide binding]; other site 713604008797 Cupin domain; Region: Cupin_2; pfam07883 713604008798 Homeodomain-like domain; Region: HTH_23; pfam13384 713604008799 Winged helix-turn helix; Region: HTH_29; pfam13551 713604008800 Homeodomain-like domain; Region: HTH_32; pfam13565 713604008801 DDE superfamily endonuclease; Region: DDE_3; pfam13358 713604008802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 713604008803 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604008804 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604008805 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604008806 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 713604008807 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 713604008808 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 713604008809 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 713604008810 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604008811 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604008812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604008813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604008814 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 713604008815 dimerization interface [polypeptide binding]; other site 713604008816 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 713604008817 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 713604008818 putative Iron-sulfur protein interface [polypeptide binding]; other site 713604008819 proximal heme binding site [chemical binding]; other site 713604008820 distal heme binding site [chemical binding]; other site 713604008821 putative dimer interface [polypeptide binding]; other site 713604008822 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 713604008823 L-aspartate oxidase; Provisional; Region: PRK06175 713604008824 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 713604008825 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 713604008826 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 713604008827 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 713604008828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604008829 dimerization interface [polypeptide binding]; other site 713604008830 putative DNA binding site [nucleotide binding]; other site 713604008831 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604008832 putative Zn2+ binding site [ion binding]; other site 713604008833 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 713604008834 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 713604008835 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604008836 MarR family; Region: MarR; pfam01047 713604008837 MarR family; Region: MarR_2; cl17246 713604008838 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 713604008839 Phosphoesterase family; Region: Phosphoesterase; pfam04185 713604008840 Domain of unknown function (DUF756); Region: DUF756; pfam05506 713604008841 Domain of unknown function (DUF756); Region: DUF756; pfam05506 713604008842 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 713604008843 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 713604008844 O-methyltransferase; Region: Methyltransf_2; pfam00891 713604008845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604008846 sequence-specific DNA binding site [nucleotide binding]; other site 713604008847 salt bridge; other site 713604008848 Cupin domain; Region: Cupin_2; pfam07883 713604008849 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 713604008850 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 713604008851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604008852 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 713604008853 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 713604008854 dihydrodipicolinate synthase; Region: dapA; TIGR00674 713604008855 active site 713604008856 inhibitor site; inhibition site 713604008857 dimer interface [polypeptide binding]; other site 713604008858 catalytic residue [active] 713604008859 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 713604008860 Proline racemase; Region: Pro_racemase; pfam05544 713604008861 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604008862 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604008863 active site 713604008864 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604008865 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604008866 ligand binding site [chemical binding]; other site 713604008867 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604008868 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604008869 ligand binding site [chemical binding]; other site 713604008870 flexible hinge region; other site 713604008871 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 713604008872 substrate binding pocket [chemical binding]; other site 713604008873 substrate-Mg2+ binding site; other site 713604008874 aspartate-rich region 1; other site 713604008875 aspartate-rich region 2; other site 713604008876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604008877 S-adenosylmethionine binding site [chemical binding]; other site 713604008878 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604008879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008880 dimer interface [polypeptide binding]; other site 713604008881 conserved gate region; other site 713604008882 ABC-ATPase subunit interface; other site 713604008883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604008884 dimer interface [polypeptide binding]; other site 713604008885 conserved gate region; other site 713604008886 putative PBP binding loops; other site 713604008887 ABC-ATPase subunit interface; other site 713604008888 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604008889 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604008890 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 713604008891 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 713604008892 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 713604008893 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 713604008894 active site 713604008895 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 713604008896 active site 713604008897 DNA binding site [nucleotide binding] 713604008898 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 713604008899 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 713604008900 DNA binding site [nucleotide binding] 713604008901 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 713604008902 nucleotide binding site [chemical binding]; other site 713604008903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008905 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604008906 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604008907 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604008908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604008909 S-adenosylmethionine binding site [chemical binding]; other site 713604008910 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 713604008911 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 713604008912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604008913 motif II; other site 713604008914 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 713604008915 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 713604008916 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 713604008917 active site 713604008918 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604008919 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604008920 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 713604008921 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008922 acyl-activating enzyme (AAE) consensus motif; other site 713604008923 AMP binding site [chemical binding]; other site 713604008924 active site 713604008925 CoA binding site [chemical binding]; other site 713604008926 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604008927 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604008928 substrate binding site [chemical binding]; other site 713604008929 oxyanion hole (OAH) forming residues; other site 713604008930 trimer interface [polypeptide binding]; other site 713604008931 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604008932 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008933 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604008934 acyl-activating enzyme (AAE) consensus motif; other site 713604008935 acyl-activating enzyme (AAE) consensus motif; other site 713604008936 putative AMP binding site [chemical binding]; other site 713604008937 putative active site [active] 713604008938 putative CoA binding site [chemical binding]; other site 713604008939 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 713604008940 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 713604008941 catalytic Zn binding site [ion binding]; other site 713604008942 NAD binding site [chemical binding]; other site 713604008943 structural Zn binding site [ion binding]; other site 713604008944 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604008945 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604008946 NAD(P) binding site [chemical binding]; other site 713604008947 catalytic residues [active] 713604008948 BNR repeat-like domain; Region: BNR_2; pfam13088 713604008949 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 713604008950 Asp-box motif; other site 713604008951 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604008952 anti sigma factor interaction site; other site 713604008953 regulatory phosphorylation site [posttranslational modification]; other site 713604008954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604008955 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604008956 NAD(P) binding site [chemical binding]; other site 713604008957 active site 713604008958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604008959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604008960 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 713604008961 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 713604008962 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 713604008963 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604008964 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604008965 ATP binding site [chemical binding]; other site 713604008966 Mg2+ binding site [ion binding]; other site 713604008967 G-X-G motif; other site 713604008968 SET domain; Region: SET; cl02566 713604008969 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604008970 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604008971 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604008972 acyl-activating enzyme (AAE) consensus motif; other site 713604008973 AMP binding site [chemical binding]; other site 713604008974 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 713604008975 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604008976 putative trimer interface [polypeptide binding]; other site 713604008977 putative CoA binding site [chemical binding]; other site 713604008978 Cellulose binding domain; Region: CBM_2; pfam00553 713604008979 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 713604008980 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 713604008981 active site 713604008982 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 713604008983 substrate binding site [chemical binding]; other site 713604008984 active site 713604008985 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 713604008986 metal binding site [ion binding]; metal-binding site 713604008987 ligand binding site [chemical binding]; other site 713604008988 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604008989 CBD_II domain; Region: CBD_II; smart00637 713604008990 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 713604008991 active site 713604008992 catalytic triad [active] 713604008993 oxyanion hole [active] 713604008994 Cellulose binding domain; Region: CBM_2; pfam00553 713604008995 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 713604008996 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 713604008997 active site 713604008998 catalytic triad [active] 713604008999 oxyanion hole [active] 713604009000 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009001 putative sugar binding sites [chemical binding]; other site 713604009002 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009003 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009004 putative sugar binding sites [chemical binding]; other site 713604009005 Q-X-W motif; other site 713604009006 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 713604009007 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 713604009008 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009009 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009010 putative sugar binding sites [chemical binding]; other site 713604009011 Q-X-W motif; other site 713604009012 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604009013 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009014 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009015 putative sugar binding sites [chemical binding]; other site 713604009016 Q-X-W motif; other site 713604009017 Right handed beta helix region; Region: Beta_helix; pfam13229 713604009018 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009019 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009020 putative sugar binding sites [chemical binding]; other site 713604009021 Q-X-W motif; other site 713604009022 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604009023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604009024 DNA-binding site [nucleotide binding]; DNA binding site 713604009025 FCD domain; Region: FCD; pfam07729 713604009026 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 713604009027 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009028 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009029 putative sugar binding sites [chemical binding]; other site 713604009030 Q-X-W motif; other site 713604009031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604009032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604009033 DNA binding site [nucleotide binding] 713604009034 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 713604009035 putative dimerization interface [polypeptide binding]; other site 713604009036 putative ligand binding site [chemical binding]; other site 713604009037 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604009038 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009039 putative sugar binding sites [chemical binding]; other site 713604009040 Q-X-W motif; other site 713604009041 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604009042 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 713604009043 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009044 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009045 putative sugar binding sites [chemical binding]; other site 713604009046 Q-X-W motif; other site 713604009047 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 713604009048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009052 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604009053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604009055 DNA binding residues [nucleotide binding] 713604009056 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604009057 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 713604009058 putative NAD(P) binding site [chemical binding]; other site 713604009059 active site 713604009060 thiamine pyrophosphate protein; Provisional; Region: PRK08273 713604009061 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 713604009062 PYR/PP interface [polypeptide binding]; other site 713604009063 dimer interface [polypeptide binding]; other site 713604009064 tetramer interface [polypeptide binding]; other site 713604009065 TPP binding site [chemical binding]; other site 713604009066 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604009067 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 713604009068 TPP-binding site [chemical binding]; other site 713604009069 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604009070 MarR family; Region: MarR_2; pfam12802 713604009071 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 713604009072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604009073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604009074 ATP binding site [chemical binding]; other site 713604009075 Mg2+ binding site [ion binding]; other site 713604009076 G-X-G motif; other site 713604009077 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 713604009078 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604009079 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 713604009080 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604009081 DNA-binding site [nucleotide binding]; DNA binding site 713604009082 transcriptional regulator protein; Region: phnR; TIGR03337 713604009083 UTRA domain; Region: UTRA; pfam07702 713604009084 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 713604009085 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 713604009086 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 713604009087 active site 713604009088 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604009089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604009090 dimer interface [polypeptide binding]; other site 713604009091 conserved gate region; other site 713604009092 putative PBP binding loops; other site 713604009093 ABC-ATPase subunit interface; other site 713604009094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604009095 dimer interface [polypeptide binding]; other site 713604009096 conserved gate region; other site 713604009097 putative PBP binding loops; other site 713604009098 ABC-ATPase subunit interface; other site 713604009099 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604009100 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604009101 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 713604009102 active site 713604009103 catalytic residues [active] 713604009104 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 713604009105 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604009106 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 713604009107 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 713604009108 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604009109 catalytic residue [active] 713604009110 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604009111 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604009112 active site 713604009113 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604009114 putative DNA binding site [nucleotide binding]; other site 713604009115 putative Zn2+ binding site [ion binding]; other site 713604009116 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 713604009117 Low molecular weight phosphatase family; Region: LMWPc; cl00105 713604009118 active site 713604009119 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604009120 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009121 active site 713604009122 Predicted ATPase [General function prediction only]; Region: COG3903 713604009123 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604009124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604009125 DNA binding residues [nucleotide binding] 713604009126 dimerization interface [polypeptide binding]; other site 713604009127 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604009128 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604009129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604009130 metal binding site [ion binding]; metal-binding site 713604009131 active site 713604009132 I-site; other site 713604009133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604009134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604009135 DNA binding site [nucleotide binding] 713604009136 domain linker motif; other site 713604009137 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604009138 dimerization interface [polypeptide binding]; other site 713604009139 ligand binding site [chemical binding]; other site 713604009140 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 713604009141 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604009142 hydrophobic ligand binding site; other site 713604009143 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009144 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009145 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604009146 active site 713604009147 substrate binding sites [chemical binding]; other site 713604009148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009149 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 713604009150 DNA-binding interface [nucleotide binding]; DNA binding site 713604009151 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604009152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604009154 DNA binding residues [nucleotide binding] 713604009155 MarR family; Region: MarR; pfam01047 713604009156 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 713604009157 dimerization interface [polypeptide binding]; other site 713604009158 active site 713604009159 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 713604009160 active site 713604009161 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604009162 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 713604009163 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 713604009164 putative substrate binding site [chemical binding]; other site 713604009165 active site 713604009166 serine/threonine protein kinase; Provisional; Region: PRK14879 713604009167 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009169 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604009170 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604009171 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604009172 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604009173 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604009174 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 713604009175 synthetase active site [active] 713604009176 NTP binding site [chemical binding]; other site 713604009177 metal binding site [ion binding]; metal-binding site 713604009178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009179 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604009180 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604009181 Cytochrome P450; Region: p450; cl12078 713604009182 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 713604009183 active site 713604009184 Zn binding site [ion binding]; other site 713604009185 LysE type translocator; Region: LysE; cl00565 713604009186 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 713604009187 HSP70 interaction site [polypeptide binding]; other site 713604009188 Nuclease-related domain; Region: NERD; pfam08378 713604009189 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604009190 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 713604009191 acyl-activating enzyme (AAE) consensus motif; other site 713604009192 AMP binding site [chemical binding]; other site 713604009193 active site 713604009194 CoA binding site [chemical binding]; other site 713604009195 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604009196 DinB superfamily; Region: DinB_2; pfam12867 713604009197 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 713604009198 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604009199 substrate binding pocket [chemical binding]; other site 713604009200 membrane-bound complex binding site; other site 713604009201 hinge residues; other site 713604009202 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 713604009203 active site 713604009204 catalytic residues [active] 713604009205 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604009206 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 713604009207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604009208 putative substrate translocation pore; other site 713604009209 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604009210 acyl-CoA synthetase; Validated; Region: PRK05850 713604009211 acyl-activating enzyme (AAE) consensus motif; other site 713604009212 active site 713604009213 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604009214 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604009215 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 713604009216 active site 713604009217 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604009218 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604009219 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604009220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009221 KR domain; Region: KR; pfam08659 713604009222 NAD(P) binding site [chemical binding]; other site 713604009223 active site 713604009224 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604009225 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 713604009226 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 713604009227 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 713604009228 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604009229 Putative esterase; Region: Esterase; pfam00756 713604009230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 713604009231 Secretory lipase; Region: LIP; pfam03583 713604009232 Cutinase; Region: Cutinase; pfam01083 713604009233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009235 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604009236 short chain dehydrogenase; Provisional; Region: PRK07856 713604009237 classical (c) SDRs; Region: SDR_c; cd05233 713604009238 NAD(P) binding site [chemical binding]; other site 713604009239 active site 713604009240 short chain dehydrogenase; Provisional; Region: PRK07791 713604009241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009242 NAD(P) binding site [chemical binding]; other site 713604009243 active site 713604009244 enoyl-CoA hydratase; Provisional; Region: PRK06495 713604009245 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604009246 substrate binding site [chemical binding]; other site 713604009247 oxyanion hole (OAH) forming residues; other site 713604009248 trimer interface [polypeptide binding]; other site 713604009249 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 713604009250 Coenzyme A transferase; Region: CoA_trans; cl17247 713604009251 Nitronate monooxygenase; Region: NMO; pfam03060 713604009252 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 713604009253 FMN binding site [chemical binding]; other site 713604009254 substrate binding site [chemical binding]; other site 713604009255 putative catalytic residue [active] 713604009256 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 713604009257 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604009258 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604009259 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 713604009260 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604009261 dimer interface [polypeptide binding]; other site 713604009262 active site 713604009263 short chain dehydrogenase; Provisional; Region: PRK07831 713604009264 classical (c) SDRs; Region: SDR_c; cd05233 713604009265 NAD(P) binding site [chemical binding]; other site 713604009266 active site 713604009267 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009268 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 713604009269 active site 713604009270 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 713604009271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604009272 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 713604009273 acyl-activating enzyme (AAE) consensus motif; other site 713604009274 putative AMP binding site [chemical binding]; other site 713604009275 putative active site [active] 713604009276 putative CoA binding site [chemical binding]; other site 713604009277 enoyl-CoA hydratase; Provisional; Region: PRK08290 713604009278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604009279 substrate binding site [chemical binding]; other site 713604009280 oxyanion hole (OAH) forming residues; other site 713604009281 trimer interface [polypeptide binding]; other site 713604009282 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604009283 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009284 active site 713604009285 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604009286 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604009287 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009288 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 713604009289 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009290 active site 713604009291 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604009292 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 713604009294 Putative zinc-finger; Region: zf-HC2; pfam13490 713604009295 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 713604009296 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604009297 putative metal binding site [ion binding]; other site 713604009298 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604009299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604009300 DNA-binding site [nucleotide binding]; DNA binding site 713604009301 FCD domain; Region: FCD; pfam07729 713604009302 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 713604009303 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604009304 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 713604009305 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 713604009306 active site 713604009307 substrate binding site [chemical binding]; other site 713604009308 Mg2+ binding site [ion binding]; other site 713604009309 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 713604009310 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604009311 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604009312 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009313 NAD(P) binding site [chemical binding]; other site 713604009314 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604009315 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604009316 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604009317 dimerization interface [polypeptide binding]; other site 713604009318 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 713604009319 cyclase homology domain; Region: CHD; cd07302 713604009320 nucleotidyl binding site; other site 713604009321 metal binding site [ion binding]; metal-binding site 713604009322 dimer interface [polypeptide binding]; other site 713604009323 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 713604009324 Ferredoxin [Energy production and conversion]; Region: COG1146 713604009325 4Fe-4S binding domain; Region: Fer4; pfam00037 713604009326 ferredoxin-NADP+ reductase; Region: PLN02852 713604009327 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604009328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009330 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604009331 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 713604009332 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 713604009333 alpha-galactosidase; Region: PLN02808; cl17638 713604009334 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 713604009335 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009336 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009337 putative sugar binding sites [chemical binding]; other site 713604009338 Q-X-W motif; other site 713604009339 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604009340 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604009341 DNA binding site [nucleotide binding] 713604009342 domain linker motif; other site 713604009343 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604009344 dimerization interface [polypeptide binding]; other site 713604009345 ligand binding site [chemical binding]; other site 713604009346 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604009347 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604009348 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604009349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604009350 putative PBP binding loops; other site 713604009351 ABC-ATPase subunit interface; other site 713604009352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604009353 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604009354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 713604009355 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 713604009356 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009357 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009358 putative sugar binding sites [chemical binding]; other site 713604009359 Q-X-W motif; other site 713604009360 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009361 putative sugar binding sites [chemical binding]; other site 713604009362 Q-X-W motif; other site 713604009363 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009364 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 713604009365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 713604009366 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 713604009367 Ca binding site [ion binding]; other site 713604009368 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 713604009369 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 713604009370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009371 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 713604009372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604009373 putative substrate translocation pore; other site 713604009374 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604009375 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604009376 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604009377 nucleotide binding site [chemical binding]; other site 713604009378 amino acid transporter; Region: 2A0306; TIGR00909 713604009379 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604009380 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604009381 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604009382 N-acetylmannosamine kinase; Provisional; Region: PRK05082 713604009383 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604009384 nucleotide binding site [chemical binding]; other site 713604009385 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604009386 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604009387 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604009388 DNA binding site [nucleotide binding] 713604009389 domain linker motif; other site 713604009390 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604009391 ligand binding site [chemical binding]; other site 713604009392 dimerization interface [polypeptide binding]; other site 713604009393 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A; Region: PNGaseA; pfam12222 713604009394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604009395 S-adenosylmethionine binding site [chemical binding]; other site 713604009396 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604009397 Cytochrome P450; Region: p450; cl12078 713604009398 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 713604009399 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 713604009400 RibD C-terminal domain; Region: RibD_C; pfam01872 713604009401 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604009402 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 713604009403 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 713604009404 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 713604009405 probable active site [active] 713604009406 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604009407 MarR family; Region: MarR; pfam01047 713604009408 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 713604009409 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604009410 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 713604009411 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 713604009412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604009413 salt bridge; other site 713604009414 non-specific DNA binding site [nucleotide binding]; other site 713604009415 sequence-specific DNA binding site [nucleotide binding]; other site 713604009416 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604009417 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604009418 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 713604009419 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604009420 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 713604009421 putative active site [active] 713604009422 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604009423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009424 NAD(P) binding site [chemical binding]; other site 713604009425 active site 713604009426 acyl-CoA synthetase; Validated; Region: PRK06188 713604009427 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604009428 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604009429 putative active site [active] 713604009430 putative CoA binding site [chemical binding]; other site 713604009431 putative AMP binding site [chemical binding]; other site 713604009432 Survival protein SurE; Region: SurE; cl00448 713604009433 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604009434 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604009435 DNA binding residues [nucleotide binding] 713604009436 Putative zinc-finger; Region: zf-HC2; pfam13490 713604009437 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604009438 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 713604009439 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009440 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 713604009441 NAD(P) binding site [chemical binding]; other site 713604009442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009443 NAD(P) binding site [chemical binding]; other site 713604009444 active site 713604009445 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009447 D-glutamate deacylase; Validated; Region: PRK09061 713604009448 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604009449 active site 713604009450 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604009451 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 713604009452 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 713604009453 metal binding site [ion binding]; metal-binding site 713604009454 dimer interface [polypeptide binding]; other site 713604009455 Uncharacterized conserved protein [Function unknown]; Region: COG3375 713604009456 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 713604009457 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 713604009458 active site 713604009459 octamer interface [polypeptide binding]; other site 713604009460 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604009461 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604009462 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 713604009463 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 713604009464 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 713604009465 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604009466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604009467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604009468 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604009469 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604009470 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604009471 Walker A/P-loop; other site 713604009472 ATP binding site [chemical binding]; other site 713604009473 Q-loop/lid; other site 713604009474 ABC transporter signature motif; other site 713604009475 Walker B; other site 713604009476 D-loop; other site 713604009477 H-loop/switch region; other site 713604009478 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604009479 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604009480 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604009481 Walker A/P-loop; other site 713604009482 ATP binding site [chemical binding]; other site 713604009483 Q-loop/lid; other site 713604009484 ABC transporter signature motif; other site 713604009485 Walker B; other site 713604009486 D-loop; other site 713604009487 H-loop/switch region; other site 713604009488 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604009489 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 713604009490 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 713604009491 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 713604009492 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604009493 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604009494 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604009495 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604009496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604009497 putative substrate translocation pore; other site 713604009498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009499 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604009500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604009501 S-adenosylmethionine binding site [chemical binding]; other site 713604009502 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 713604009503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009504 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604009505 NAD(P) binding site [chemical binding]; other site 713604009506 active site 713604009507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604009508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604009509 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604009510 Cytochrome P450; Region: p450; cl12078 713604009511 LexA repressor; Validated; Region: PRK00215 713604009512 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 713604009513 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 713604009514 Catalytic site [active] 713604009515 Chitin binding domain; Region: Chitin_bind_3; pfam03067 713604009516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 713604009517 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604009518 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604009519 putative NAD(P) binding site [chemical binding]; other site 713604009520 glycoside hydrolase family 64: beta-1,3-glucanase B (GluB)-like; Region: GH64-GluB-like; cd09220 713604009521 substrate binding pocket [chemical binding]; other site 713604009522 catalytic residues [active] 713604009523 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 713604009524 metal binding site [ion binding]; metal-binding site 713604009525 ligand binding site [chemical binding]; other site 713604009526 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604009527 hydrophobic ligand binding site; other site 713604009528 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 713604009529 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 713604009530 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604009531 substrate binding site [chemical binding]; other site 713604009532 ATP binding site [chemical binding]; other site 713604009533 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 713604009534 active site 713604009535 intersubunit interface [polypeptide binding]; other site 713604009536 Zn2+ binding site [ion binding]; other site 713604009537 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 713604009538 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 713604009539 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 713604009540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009541 NAD(P) binding site [chemical binding]; other site 713604009542 active site 713604009543 Predicted permease; Region: DUF318; cl17795 713604009544 TIGR03943 family protein; Region: TIGR03943 713604009545 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 713604009546 NMT1/THI5 like; Region: NMT1; pfam09084 713604009547 AAA ATPase domain; Region: AAA_16; pfam13191 713604009548 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604009549 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604009550 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604009551 DNA binding residues [nucleotide binding] 713604009552 dimerization interface [polypeptide binding]; other site 713604009553 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 713604009554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009555 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 713604009556 NAD(P) binding site [chemical binding]; other site 713604009557 active site 713604009558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009560 acyl-CoA synthetase; Validated; Region: PRK06188 713604009561 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604009562 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604009563 putative active site [active] 713604009564 putative CoA binding site [chemical binding]; other site 713604009565 putative AMP binding site [chemical binding]; other site 713604009566 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604009567 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604009568 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 713604009569 classical (c) SDRs; Region: SDR_c; cd05233 713604009570 NAD(P) binding site [chemical binding]; other site 713604009571 active site 713604009572 Phosphopantetheine attachment site; Region: PP-binding; cl09936 713604009573 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 713604009574 3-oxoacyl-(acyl carrier protein) synthase II; Provisional; Region: PRK14691 713604009575 dimer interface [polypeptide binding]; other site 713604009576 active site 713604009577 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604009578 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604009579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 713604009580 DNA-binding site [nucleotide binding]; DNA binding site 713604009581 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604009582 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 713604009583 substrate binding site [chemical binding]; other site 713604009584 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604009585 hydrophobic ligand binding site; other site 713604009586 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009587 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 713604009588 NAD(P) binding site [chemical binding]; other site 713604009589 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 713604009590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604009591 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604009592 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 713604009593 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604009594 AAA ATPase domain; Region: AAA_16; pfam13191 713604009595 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604009596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604009597 DNA binding residues [nucleotide binding] 713604009598 dimerization interface [polypeptide binding]; other site 713604009599 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604009600 metal-binding site [ion binding] 713604009601 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 713604009602 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604009603 metal-binding site [ion binding] 713604009604 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604009605 Soluble P-type ATPase [General function prediction only]; Region: COG4087 713604009606 Peptidase family M48; Region: Peptidase_M48; cl12018 713604009607 Penicillinase repressor; Region: Pencillinase_R; cl17580 713604009608 Domain of unknown function (DUF305); Region: DUF305; pfam03713 713604009609 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604009610 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 713604009611 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 713604009612 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 713604009613 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604009614 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009615 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604009616 DNA binding residues [nucleotide binding] 713604009617 Putative zinc-finger; Region: zf-HC2; pfam13490 713604009618 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 713604009619 putative hydrophobic ligand binding site [chemical binding]; other site 713604009620 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604009621 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009623 TIGR01777 family protein; Region: yfcH 713604009624 NAD(P) binding site [chemical binding]; other site 713604009625 active site 713604009626 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 713604009627 SNF2 Helicase protein; Region: DUF3670; pfam12419 713604009628 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604009629 ATP binding site [chemical binding]; other site 713604009630 putative Mg++ binding site [ion binding]; other site 713604009631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604009632 nucleotide binding region [chemical binding]; other site 713604009633 ATP-binding site [chemical binding]; other site 713604009634 Uncharacterized conserved protein [Function unknown]; Region: COG4279 713604009635 AAA domain; Region: AAA_33; pfam13671 713604009636 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604009637 G1 box; other site 713604009638 GTP/Mg2+ binding site [chemical binding]; other site 713604009639 G2 box; other site 713604009640 Switch I region; other site 713604009641 Family description; Region: UvrD_C_2; pfam13538 713604009642 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604009643 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 713604009644 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604009645 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 713604009646 enterobactin exporter EntS; Provisional; Region: PRK10489 713604009647 hypothetical protein; Provisional; Region: PRK06185 713604009648 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604009649 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 713604009650 BNR repeat-like domain; Region: BNR_2; pfam13088 713604009651 BNR repeat-like domain; Region: BNR_2; pfam13088 713604009652 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 713604009653 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 713604009654 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 713604009655 active site 713604009656 FMN binding site [chemical binding]; other site 713604009657 substrate binding site [chemical binding]; other site 713604009658 3Fe-4S cluster binding site [ion binding]; other site 713604009659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604009660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604009661 active site 713604009662 phosphorylation site [posttranslational modification] 713604009663 intermolecular recognition site; other site 713604009664 dimerization interface [polypeptide binding]; other site 713604009665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604009666 DNA binding site [nucleotide binding] 713604009667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604009668 HAMP domain; Region: HAMP; pfam00672 713604009669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604009670 dimer interface [polypeptide binding]; other site 713604009671 phosphorylation site [posttranslational modification] 713604009672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604009673 ATP binding site [chemical binding]; other site 713604009674 Mg2+ binding site [ion binding]; other site 713604009675 G-X-G motif; other site 713604009676 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 713604009677 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604009678 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604009679 Walker A/P-loop; other site 713604009680 ATP binding site [chemical binding]; other site 713604009681 Q-loop/lid; other site 713604009682 ABC transporter signature motif; other site 713604009683 Walker B; other site 713604009684 D-loop; other site 713604009685 H-loop/switch region; other site 713604009686 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 713604009687 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 713604009688 FtsX-like permease family; Region: FtsX; pfam02687 713604009689 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009690 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604009691 NAD(P) binding site [chemical binding]; other site 713604009692 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604009693 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604009694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604009697 Histidine kinase; Region: HisKA_3; pfam07730 713604009698 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604009699 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604009700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604009701 active site 713604009702 phosphorylation site [posttranslational modification] 713604009703 intermolecular recognition site; other site 713604009704 dimerization interface [polypeptide binding]; other site 713604009705 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604009706 DNA binding residues [nucleotide binding] 713604009707 dimerization interface [polypeptide binding]; other site 713604009708 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604009709 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604009710 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604009711 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604009712 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 713604009713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009714 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604009715 Histidine kinase; Region: HisKA_3; pfam07730 713604009716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604009717 Response regulator receiver domain; Region: Response_reg; pfam00072 713604009718 active site 713604009719 phosphorylation site [posttranslational modification] 713604009720 intermolecular recognition site; other site 713604009721 dimerization interface [polypeptide binding]; other site 713604009722 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 713604009723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009724 NAD(P) binding site [chemical binding]; other site 713604009725 active site 713604009726 ribonuclease; Region: Ribonuclease; pfam00545 713604009727 active site 713604009728 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 713604009729 putative hydrophobic ligand binding site [chemical binding]; other site 713604009730 protein interface [polypeptide binding]; other site 713604009731 gate; other site 713604009732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604009733 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604009734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009736 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 713604009737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009738 NAD(P) binding site [chemical binding]; other site 713604009739 active site 713604009740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009741 active site 713604009742 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 713604009743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009744 NAD(P) binding site [chemical binding]; other site 713604009745 active site 713604009746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604009747 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 713604009748 benzoyl-CoA-dihydrodiol lyase; Region: benzo_boxC; TIGR03222 713604009749 CHAT domain; Region: CHAT; cl17868 713604009750 AAA domain; Region: AAA_22; pfam13401 713604009751 CHAT domain; Region: CHAT; cl17868 713604009752 SIR2-like domain; Region: SIR2_2; pfam13289 713604009753 DYW family of nucleic acid deaminases; Region: DYW_deaminase; pfam14432 713604009754 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604009755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009756 NAD(P) binding site [chemical binding]; other site 713604009757 active site 713604009758 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 713604009759 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604009760 Cytochrome P450; Region: p450; cl12078 713604009761 MarR family; Region: MarR_2; pfam12802 713604009762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 713604009763 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009764 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604009765 putative sugar binding sites [chemical binding]; other site 713604009766 Q-X-W motif; other site 713604009767 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604009768 putative sugar binding sites [chemical binding]; other site 713604009769 Q-X-W motif; other site 713604009770 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604009771 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604009772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604009773 active site 713604009774 phosphorylation site [posttranslational modification] 713604009775 intermolecular recognition site; other site 713604009776 dimerization interface [polypeptide binding]; other site 713604009777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604009778 DNA binding site [nucleotide binding] 713604009779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604009780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604009781 ATP binding site [chemical binding]; other site 713604009782 Mg2+ binding site [ion binding]; other site 713604009783 G-X-G motif; other site 713604009784 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 713604009785 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 713604009786 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 713604009787 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604009788 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604009789 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 713604009790 NodB motif; other site 713604009791 active site 713604009792 catalytic site [active] 713604009793 metal binding site [ion binding]; metal-binding site 713604009794 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604009795 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604009796 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604009797 ATP binding site [chemical binding]; other site 713604009798 Mg2+ binding site [ion binding]; other site 713604009799 G-X-G motif; other site 713604009800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604009801 PAS domain; Region: PAS_9; pfam13426 713604009802 putative active site [active] 713604009803 heme pocket [chemical binding]; other site 713604009804 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 713604009805 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 713604009806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604009807 S-adenosylmethionine binding site [chemical binding]; other site 713604009808 PAS domain; Region: PAS_9; pfam13426 713604009809 CheB methylesterase; Region: CheB_methylest; pfam01339 713604009810 hypothetical protein; Provisional; Region: PRK07236 713604009811 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 713604009812 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604009813 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604009814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604009816 TPR motif; other site 713604009817 binding surface 713604009818 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604009819 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604009820 putative NAD(P) binding site [chemical binding]; other site 713604009821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009823 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 713604009824 alanine dehydrogenase; Region: alaDH; TIGR00518 713604009825 putative active site [active] 713604009826 putative ligand binding site [chemical binding]; other site 713604009827 putative NAD(P) binding site [chemical binding]; other site 713604009828 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 713604009829 active site clefts [active] 713604009830 zinc binding site [ion binding]; other site 713604009831 dimer interface [polypeptide binding]; other site 713604009832 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604009833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009835 WHG domain; Region: WHG; pfam13305 713604009836 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009837 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009838 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604009839 Cupin domain; Region: Cupin_2; pfam07883 713604009840 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604009841 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 713604009842 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604009843 anti sigma factor interaction site; other site 713604009844 regulatory phosphorylation site [posttranslational modification]; other site 713604009845 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009846 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009847 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604009848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604009849 NAD(P) binding site [chemical binding]; other site 713604009850 active site 713604009851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 713604009852 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604009853 WD40 repeats; Region: WD40; smart00320 713604009854 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 713604009855 structural tetrad; other site 713604009856 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604009857 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 713604009858 structural tetrad; other site 713604009859 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604009860 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604009861 DNA binding residues [nucleotide binding] 713604009862 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604009863 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009864 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604009865 DNA binding residues [nucleotide binding] 713604009866 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604009867 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 713604009868 classical (c) SDRs; Region: SDR_c; cd05233 713604009869 NAD(P) binding site [chemical binding]; other site 713604009870 active site 713604009871 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604009872 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 713604009873 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604009874 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604009875 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 713604009876 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604009877 active site 713604009878 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604009879 Peptidase M15; Region: Peptidase_M15_3; cl01194 713604009880 Helix-turn-helix domain; Region: HTH_31; pfam13560 713604009881 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 713604009882 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604009883 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604009884 DNA binding site [nucleotide binding] 713604009885 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604009886 AAA ATPase domain; Region: AAA_16; pfam13191 713604009887 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604009888 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604009889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604009890 TPR motif; other site 713604009891 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604009892 binding surface 713604009893 NTPase; Region: NTPase_1; cl17478 713604009894 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604009895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604009896 DNA binding residues [nucleotide binding] 713604009897 dimerization interface [polypeptide binding]; other site 713604009898 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 713604009899 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604009900 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604009901 active site 713604009902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604009903 acyl carrier protein; Provisional; Region: PRK07639 713604009904 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 713604009905 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 713604009906 dimer interface [polypeptide binding]; other site 713604009907 active site 713604009908 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604009909 catalytic residues [active] 713604009910 substrate binding site [chemical binding]; other site 713604009911 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604009912 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 713604009913 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 713604009914 Condensation domain; Region: Condensation; pfam00668 713604009915 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604009916 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604009917 Walker A/P-loop; other site 713604009918 ATP binding site [chemical binding]; other site 713604009919 Q-loop/lid; other site 713604009920 ABC transporter signature motif; other site 713604009921 Walker B; other site 713604009922 D-loop; other site 713604009923 H-loop/switch region; other site 713604009924 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604009925 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604009926 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 713604009927 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 713604009928 Amidinotransferase; Region: Amidinotransf; cl12043 713604009929 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 713604009930 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 713604009931 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604009932 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604009933 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604009934 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604009935 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 713604009936 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604009937 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604009938 catalytic loop [active] 713604009939 iron binding site [ion binding]; other site 713604009940 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604009941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009942 alpha-galactosidase; Region: PLN02808; cl17638 713604009943 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 713604009944 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 713604009945 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604009946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009947 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604009948 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604009949 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604009950 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604009951 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604009952 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604009953 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604009954 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604009955 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604009956 classical (c) SDRs; Region: SDR_c; cd05233 713604009957 NAD(P) binding site [chemical binding]; other site 713604009958 active site 713604009959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604009960 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604009961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604009962 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604009963 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604009964 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604009965 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604009966 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604009967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009969 WHG domain; Region: WHG; pfam13305 713604009970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604009971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604009972 WHG domain; Region: WHG; pfam13305 713604009973 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604009974 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604009975 NAD(P) binding site [chemical binding]; other site 713604009976 Protein of unknown function (DUF998); Region: DUF998; pfam06197 713604009977 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604009978 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604009979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604009980 dimerization interface [polypeptide binding]; other site 713604009981 putative DNA binding site [nucleotide binding]; other site 713604009982 putative Zn2+ binding site [ion binding]; other site 713604009983 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604009984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604009985 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 713604009986 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 713604009987 putative dimerization interface [polypeptide binding]; other site 713604009988 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604009989 catalytic triad [active] 713604009990 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 713604009991 active site 713604009992 catalytic triad [active] 713604009993 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 713604009994 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 713604009995 substrate binding site [chemical binding]; other site 713604009996 active site 713604009997 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 713604009998 active site 713604009999 catalytic triad [active] 713604010000 oxyanion hole [active] 713604010001 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604010002 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604010003 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010004 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010005 putative sugar binding sites [chemical binding]; other site 713604010006 Q-X-W motif; other site 713604010007 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604010008 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 713604010009 active site 713604010010 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604010011 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604010012 Condensation domain; Region: Condensation; pfam00668 713604010013 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604010014 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604010015 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 713604010016 acyl-activating enzyme (AAE) consensus motif; other site 713604010017 AMP binding site [chemical binding]; other site 713604010018 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604010019 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604010020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604010021 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604010022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604010023 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 713604010024 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604010025 acyl-activating enzyme (AAE) consensus motif; other site 713604010026 AMP binding site [chemical binding]; other site 713604010027 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604010028 Condensation domain; Region: Condensation; pfam00668 713604010029 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604010030 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604010031 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604010032 Condensation domain; Region: Condensation; pfam00668 713604010033 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604010034 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604010035 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010036 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604010037 acyl-activating enzyme (AAE) consensus motif; other site 713604010038 AMP binding site [chemical binding]; other site 713604010039 active site 713604010040 CoA binding site [chemical binding]; other site 713604010041 ApbE family; Region: ApbE; pfam02424 713604010042 FMN-binding domain; Region: FMN_bind; cl01081 713604010043 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 713604010044 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 713604010045 FAD binding pocket [chemical binding]; other site 713604010046 FAD binding motif [chemical binding]; other site 713604010047 phosphate binding motif [ion binding]; other site 713604010048 beta-alpha-beta structure motif; other site 713604010049 NAD binding pocket [chemical binding]; other site 713604010050 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604010051 dimerization interface [polypeptide binding]; other site 713604010052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604010053 dimer interface [polypeptide binding]; other site 713604010054 phosphorylation site [posttranslational modification] 713604010055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604010056 ATP binding site [chemical binding]; other site 713604010057 Mg2+ binding site [ion binding]; other site 713604010058 G-X-G motif; other site 713604010059 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604010060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604010061 active site 713604010062 phosphorylation site [posttranslational modification] 713604010063 intermolecular recognition site; other site 713604010064 dimerization interface [polypeptide binding]; other site 713604010065 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604010066 DNA binding site [nucleotide binding] 713604010067 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604010068 active site 713604010069 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 713604010070 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604010071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604010072 active site 713604010073 phosphorylation site [posttranslational modification] 713604010074 intermolecular recognition site; other site 713604010075 dimerization interface [polypeptide binding]; other site 713604010076 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604010077 DNA binding residues [nucleotide binding] 713604010078 dimerization interface [polypeptide binding]; other site 713604010079 Histidine kinase; Region: HisKA_3; pfam07730 713604010080 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604010081 hypothetical protein; Provisional; Region: PRK06184 713604010082 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604010083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604010084 S-adenosylmethionine binding site [chemical binding]; other site 713604010085 Transposase, Mutator family; Region: Transposase_mut; pfam00872 713604010086 Transposase, Mutator family; Region: Transposase_mut; pfam00872 713604010087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010089 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 713604010090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604010091 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 713604010092 NAD(P) binding site [chemical binding]; other site 713604010093 active site 713604010094 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604010095 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604010096 putative DNA binding site [nucleotide binding]; other site 713604010097 putative Zn2+ binding site [ion binding]; other site 713604010098 AsnC family; Region: AsnC_trans_reg; pfam01037 713604010099 EamA-like transporter family; Region: EamA; pfam00892 713604010100 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604010101 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604010102 putative NAD(P) binding site [chemical binding]; other site 713604010103 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604010104 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 713604010105 NmrA-like family; Region: NmrA; pfam05368 713604010106 NADP binding site [chemical binding]; other site 713604010107 active site 713604010108 regulatory binding site [polypeptide binding]; other site 713604010109 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604010110 MarR family; Region: MarR; pfam01047 713604010111 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604010112 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604010113 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604010114 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 713604010115 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010116 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010117 putative sugar binding sites [chemical binding]; other site 713604010118 Q-X-W motif; other site 713604010119 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604010120 Interdomain contacts; other site 713604010121 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604010122 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604010123 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604010124 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 713604010125 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 713604010126 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604010127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604010128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604010129 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604010130 salt bridge; other site 713604010131 non-specific DNA binding site [nucleotide binding]; other site 713604010132 sequence-specific DNA binding site [nucleotide binding]; other site 713604010133 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604010134 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604010135 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604010136 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 713604010137 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604010138 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604010139 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604010140 catalytic loop [active] 713604010141 iron binding site [ion binding]; other site 713604010142 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604010143 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604010144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604010145 putative substrate translocation pore; other site 713604010146 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 713604010147 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604010148 catalytic Zn binding site [ion binding]; other site 713604010149 NAD(P) binding site [chemical binding]; other site 713604010150 structural Zn binding site [ion binding]; other site 713604010151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604010152 salt bridge; other site 713604010153 non-specific DNA binding site [nucleotide binding]; other site 713604010154 sequence-specific DNA binding site [nucleotide binding]; other site 713604010155 Uncharacterized conserved protein [Function unknown]; Region: COG4925 713604010156 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 713604010157 RibD C-terminal domain; Region: RibD_C; cl17279 713604010158 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 713604010159 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604010160 active site 713604010161 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604010162 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 713604010163 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 713604010164 WHG domain; Region: WHG; pfam13305 713604010165 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 713604010166 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604010167 dimerization interface [polypeptide binding]; other site 713604010168 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 713604010169 putative active cleft [active] 713604010170 MarR family; Region: MarR_2; pfam12802 713604010171 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604010172 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604010173 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 713604010174 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 713604010175 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 713604010176 substrate binding site [chemical binding]; other site 713604010177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604010178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604010179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010180 putative PBP binding loops; other site 713604010181 dimer interface [polypeptide binding]; other site 713604010182 ABC-ATPase subunit interface; other site 713604010183 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604010184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010185 dimer interface [polypeptide binding]; other site 713604010186 conserved gate region; other site 713604010187 putative PBP binding loops; other site 713604010188 ABC-ATPase subunit interface; other site 713604010189 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604010190 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 713604010191 Walker A/P-loop; other site 713604010192 ATP binding site [chemical binding]; other site 713604010193 Q-loop/lid; other site 713604010194 ABC transporter signature motif; other site 713604010195 Walker B; other site 713604010196 D-loop; other site 713604010197 H-loop/switch region; other site 713604010198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604010199 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604010200 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604010201 Walker A/P-loop; other site 713604010202 ATP binding site [chemical binding]; other site 713604010203 Q-loop/lid; other site 713604010204 ABC transporter signature motif; other site 713604010205 Walker B; other site 713604010206 D-loop; other site 713604010207 H-loop/switch region; other site 713604010208 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604010209 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 713604010210 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604010211 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604010212 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604010213 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604010214 ligand binding site [chemical binding]; other site 713604010215 dimerization interface [polypeptide binding]; other site 713604010216 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010217 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010218 putative sugar binding sites [chemical binding]; other site 713604010219 Q-X-W motif; other site 713604010220 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 713604010221 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 713604010222 active site 713604010223 catalytic triad [active] 713604010224 oxyanion hole [active] 713604010225 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010226 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010227 putative sugar binding sites [chemical binding]; other site 713604010228 Q-X-W motif; other site 713604010229 MarR family; Region: MarR_2; cl17246 713604010230 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604010231 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604010232 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 713604010233 Melibiase; Region: Melibiase; pfam02065 713604010234 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010235 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010236 active site 713604010237 Cupin; Region: Cupin_6; pfam12852 713604010238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604010239 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604010240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604010241 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604010242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010243 hypothetical protein; Provisional; Region: PRK06126 713604010244 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604010245 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 713604010246 active site 713604010247 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 713604010248 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 713604010249 active site 713604010250 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604010251 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604010252 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604010253 DNA binding residues [nucleotide binding] 713604010254 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604010255 iron-sulfur cluster [ion binding]; other site 713604010256 [2Fe-2S] cluster binding site [ion binding]; other site 713604010257 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 713604010258 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 713604010259 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 713604010260 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 713604010261 active site 713604010262 catalytic triad [active] 713604010263 oxyanion hole [active] 713604010264 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604010265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604010266 active site 713604010267 phosphorylation site [posttranslational modification] 713604010268 intermolecular recognition site; other site 713604010269 dimerization interface [polypeptide binding]; other site 713604010270 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604010271 DNA binding site [nucleotide binding] 713604010272 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604010273 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604010274 dimerization interface [polypeptide binding]; other site 713604010275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604010276 dimer interface [polypeptide binding]; other site 713604010277 phosphorylation site [posttranslational modification] 713604010278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604010279 ATP binding site [chemical binding]; other site 713604010280 Mg2+ binding site [ion binding]; other site 713604010281 G-X-G motif; other site 713604010282 Acyltransferase family; Region: Acyl_transf_3; pfam01757 713604010283 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604010284 Methyltransferase domain; Region: Methyltransf_26; pfam13659 713604010285 AAA domain; Region: AAA_17; pfam13207 713604010286 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604010287 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604010288 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604010289 DNA binding residues [nucleotide binding] 713604010290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604010291 S-adenosylmethionine binding site [chemical binding]; other site 713604010292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604010293 putative DNA binding site [nucleotide binding]; other site 713604010294 dimerization interface [polypeptide binding]; other site 713604010295 putative Zn2+ binding site [ion binding]; other site 713604010296 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 713604010297 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604010298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604010299 non-specific DNA binding site [nucleotide binding]; other site 713604010300 salt bridge; other site 713604010301 sequence-specific DNA binding site [nucleotide binding]; other site 713604010302 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 713604010303 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 713604010304 Acylphosphatase; Region: Acylphosphatase; pfam00708 713604010305 HypF finger; Region: zf-HYPF; pfam07503 713604010306 HypF finger; Region: zf-HYPF; pfam07503 713604010307 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 713604010308 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604010309 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 713604010310 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 713604010311 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 713604010312 dimerization interface [polypeptide binding]; other site 713604010313 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 713604010314 ATP binding site [chemical binding]; other site 713604010315 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 713604010316 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 713604010317 HupF/HypC family; Region: HupF_HypC; pfam01455 713604010318 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 713604010319 nickel binding site [ion binding]; other site 713604010320 NifU-like domain; Region: NifU; cl00484 713604010321 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 713604010322 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 713604010323 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 713604010324 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 713604010325 dimer interface [polypeptide binding]; other site 713604010326 active site 713604010327 HupF/HypC family; Region: HupF_HypC; cl00394 713604010328 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 713604010329 dimer interface [polypeptide binding]; other site 713604010330 active site 713604010331 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010332 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010333 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010334 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010335 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010336 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604010337 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 713604010338 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 713604010339 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604010340 RHS Repeat; Region: RHS_repeat; pfam05593 713604010341 RHS Repeat; Region: RHS_repeat; pfam05593 713604010342 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604010343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604010344 NAD(P) binding site [chemical binding]; other site 713604010345 active site 713604010346 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604010347 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 713604010348 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604010349 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604010350 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604010351 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010352 substrate binding site [chemical binding]; other site 713604010353 oxyanion hole (OAH) forming residues; other site 713604010354 trimer interface [polypeptide binding]; other site 713604010355 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 713604010356 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604010357 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604010358 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604010359 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604010360 putative NAD(P) binding site [chemical binding]; other site 713604010361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010363 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604010364 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604010365 putative NAD(P) binding site [chemical binding]; other site 713604010366 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604010367 classical (c) SDRs; Region: SDR_c; cd05233 713604010368 NAD(P) binding site [chemical binding]; other site 713604010369 active site 713604010370 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604010371 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604010372 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604010373 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 713604010374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604010375 NAD(P) binding site [chemical binding]; other site 713604010376 active site 713604010377 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604010378 classical (c) SDRs; Region: SDR_c; cd05233 713604010379 NAD(P) binding site [chemical binding]; other site 713604010380 active site 713604010381 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604010382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010384 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 713604010385 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010386 acyl-activating enzyme (AAE) consensus motif; other site 713604010387 active site 713604010388 AMP binding site [chemical binding]; other site 713604010389 CoA binding site [chemical binding]; other site 713604010390 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 713604010391 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 713604010392 putative ligand binding site [chemical binding]; other site 713604010393 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 713604010394 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604010395 TM-ABC transporter signature motif; other site 713604010396 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 713604010397 TM-ABC transporter signature motif; other site 713604010398 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604010399 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 713604010400 Walker A/P-loop; other site 713604010401 ATP binding site [chemical binding]; other site 713604010402 Q-loop/lid; other site 713604010403 ABC transporter signature motif; other site 713604010404 Walker B; other site 713604010405 D-loop; other site 713604010406 H-loop/switch region; other site 713604010407 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 713604010408 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 713604010409 Walker A/P-loop; other site 713604010410 ATP binding site [chemical binding]; other site 713604010411 Q-loop/lid; other site 713604010412 ABC transporter signature motif; other site 713604010413 Walker B; other site 713604010414 D-loop; other site 713604010415 H-loop/switch region; other site 713604010416 enoyl-CoA hydratase; Provisional; Region: PRK06210 713604010417 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010418 substrate binding site [chemical binding]; other site 713604010419 oxyanion hole (OAH) forming residues; other site 713604010420 trimer interface [polypeptide binding]; other site 713604010421 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010422 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 713604010423 FAD binding site [chemical binding]; other site 713604010424 substrate binding site [chemical binding]; other site 713604010425 catalytic base [active] 713604010426 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604010427 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010428 AMP binding site [chemical binding]; other site 713604010429 active site 713604010430 acyl-activating enzyme (AAE) consensus motif; other site 713604010431 CoA binding site [chemical binding]; other site 713604010432 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 713604010433 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 713604010434 active site 713604010435 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 713604010436 catalytic triad [active] 713604010437 dimer interface [polypeptide binding]; other site 713604010438 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604010439 active site 2 [active] 713604010440 active site 1 [active] 713604010441 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604010442 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010443 substrate binding site [chemical binding]; other site 713604010444 oxyanion hole (OAH) forming residues; other site 713604010445 trimer interface [polypeptide binding]; other site 713604010446 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010447 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010448 active site 713604010449 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 713604010450 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 713604010451 NAD binding site [chemical binding]; other site 713604010452 catalytic residues [active] 713604010453 Domain of unknown function (DUF222); Region: DUF222; pfam02720 713604010454 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604010455 active site 713604010456 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604010457 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604010458 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 713604010459 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604010460 dimer interface [polypeptide binding]; other site 713604010461 active site 713604010462 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 713604010463 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 713604010464 FMN binding site [chemical binding]; other site 713604010465 substrate binding site [chemical binding]; other site 713604010466 putative catalytic residue [active] 713604010467 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604010468 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 713604010469 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604010470 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604010471 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 713604010472 tetramerization interface [polypeptide binding]; other site 713604010473 NAD(P) binding site [chemical binding]; other site 713604010474 catalytic residues [active] 713604010475 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 713604010476 CoA binding domain; Region: CoA_binding_2; pfam13380 713604010477 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 713604010478 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 713604010479 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010480 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604010481 active site 713604010482 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 713604010483 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 713604010484 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 713604010485 active site 713604010486 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 713604010487 catalytic triad [active] 713604010488 dimer interface [polypeptide binding]; other site 713604010489 Amidohydrolase; Region: Amidohydro_2; pfam04909 713604010490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010491 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010492 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010493 active site 713604010494 Amidohydrolase; Region: Amidohydro_2; pfam04909 713604010495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010496 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 713604010497 DUF35 OB-fold domain; Region: DUF35; pfam01796 713604010498 lipid-transfer protein; Provisional; Region: PRK08256 713604010499 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604010500 active site 713604010501 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 713604010502 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604010503 NAD binding site [chemical binding]; other site 713604010504 homodimer interface [polypeptide binding]; other site 713604010505 homotetramer interface [polypeptide binding]; other site 713604010506 active site 713604010507 Predicted membrane protein [Function unknown]; Region: COG2259 713604010508 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 713604010509 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604010510 dimer interface [polypeptide binding]; other site 713604010511 active site 713604010512 enoyl-CoA hydratase; Provisional; Region: PRK08252 713604010513 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010514 substrate binding site [chemical binding]; other site 713604010515 oxyanion hole (OAH) forming residues; other site 713604010516 trimer interface [polypeptide binding]; other site 713604010517 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604010518 CoenzymeA binding site [chemical binding]; other site 713604010519 subunit interaction site [polypeptide binding]; other site 713604010520 PHB binding site; other site 713604010521 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604010522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604010523 short chain dehydrogenase; Provisional; Region: PRK07791 713604010524 NAD(P) binding site [chemical binding]; other site 713604010525 active site 713604010526 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604010527 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604010528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604010529 NAD(P) binding site [chemical binding]; other site 713604010530 active site 713604010531 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604010532 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010533 substrate binding site [chemical binding]; other site 713604010534 oxyanion hole (OAH) forming residues; other site 713604010535 trimer interface [polypeptide binding]; other site 713604010536 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604010537 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010538 substrate binding site [chemical binding]; other site 713604010539 oxyanion hole (OAH) forming residues; other site 713604010540 trimer interface [polypeptide binding]; other site 713604010541 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010542 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604010543 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604010544 active site 713604010545 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010546 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010547 active site 713604010548 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604010549 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010550 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010551 acyl-activating enzyme (AAE) consensus motif; other site 713604010552 acyl-activating enzyme (AAE) consensus motif; other site 713604010553 active site 713604010554 AMP binding site [chemical binding]; other site 713604010555 CoA binding site [chemical binding]; other site 713604010556 lipid-transfer protein; Provisional; Region: PRK07855 713604010557 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604010558 active site 713604010559 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 713604010560 DUF35 OB-fold domain; Region: DUF35; pfam01796 713604010561 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 713604010562 putative active site [active] 713604010563 putative catalytic site [active] 713604010564 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604010565 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604010566 DNA-binding site [nucleotide binding]; DNA binding site 713604010567 FCD domain; Region: FCD; pfam07729 713604010568 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010569 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010570 active site 713604010571 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 713604010572 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 713604010573 conserved cys residue [active] 713604010574 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604010575 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 713604010576 NAD(P) binding site [chemical binding]; other site 713604010577 catalytic residues [active] 713604010578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010579 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604010580 active site 713604010581 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604010582 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604010583 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604010584 active site 713604010585 enoyl-CoA hydratase; Provisional; Region: PRK08260 713604010586 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010587 substrate binding site [chemical binding]; other site 713604010588 oxyanion hole (OAH) forming residues; other site 713604010589 trimer interface [polypeptide binding]; other site 713604010590 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604010591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604010592 DNA-binding site [nucleotide binding]; DNA binding site 713604010593 FCD domain; Region: FCD; pfam07729 713604010594 short chain dehydrogenase; Provisional; Region: PRK06180 713604010595 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604010596 NADP binding site [chemical binding]; other site 713604010597 active site 713604010598 steroid binding site; other site 713604010599 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 713604010600 dihydropteroate synthase; Region: DHPS; TIGR01496 713604010601 substrate binding pocket [chemical binding]; other site 713604010602 dimer interface [polypeptide binding]; other site 713604010603 inhibitor binding site; inhibition site 713604010604 acyl-CoA synthetase; Validated; Region: PRK07798 713604010605 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010606 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 713604010607 acyl-activating enzyme (AAE) consensus motif; other site 713604010608 acyl-activating enzyme (AAE) consensus motif; other site 713604010609 putative AMP binding site [chemical binding]; other site 713604010610 putative active site [active] 713604010611 putative CoA binding site [chemical binding]; other site 713604010612 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604010613 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604010614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010615 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604010616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010618 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604010619 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 713604010620 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 713604010621 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604010622 sequence-specific DNA binding site [nucleotide binding]; other site 713604010623 salt bridge; other site 713604010624 AAA ATPase domain; Region: AAA_16; pfam13191 713604010625 NB-ARC domain; Region: NB-ARC; pfam00931 713604010626 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 713604010627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604010628 TPR motif; other site 713604010629 binding surface 713604010630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604010631 TPR motif; other site 713604010632 binding surface 713604010633 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604010634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 713604010635 MOSC domain; Region: MOSC; pfam03473 713604010636 3-alpha domain; Region: 3-alpha; pfam03475 713604010637 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 713604010638 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 713604010639 FAD binding pocket [chemical binding]; other site 713604010640 FAD binding motif [chemical binding]; other site 713604010641 phosphate binding motif [ion binding]; other site 713604010642 beta-alpha-beta structure motif; other site 713604010643 NAD binding pocket [chemical binding]; other site 713604010644 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604010645 catalytic loop [active] 713604010646 iron binding site [ion binding]; other site 713604010647 dimerization interface [polypeptide binding]; other site 713604010648 putative DNA binding site [nucleotide binding]; other site 713604010649 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604010650 putative Zn2+ binding site [ion binding]; other site 713604010651 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604010652 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604010653 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 713604010654 hypothetical protein; Provisional; Region: PRK07907 713604010655 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 713604010656 active site 713604010657 metal binding site [ion binding]; metal-binding site 713604010658 dimer interface [polypeptide binding]; other site 713604010659 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 713604010660 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 713604010661 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604010662 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604010663 Short C-terminal domain; Region: SHOCT; pfam09851 713604010664 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 713604010665 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604010666 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604010667 DNA binding residues [nucleotide binding] 713604010668 dimerization interface [polypeptide binding]; other site 713604010669 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 713604010670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 713604010671 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 713604010672 Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399 713604010673 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604010674 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604010675 DNA binding residues [nucleotide binding] 713604010676 Domain of unknown function DUF20; Region: UPF0118; pfam01594 713604010677 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 713604010678 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 713604010679 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604010680 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604010681 alpha-galactosidase; Provisional; Region: PRK15076 713604010682 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 713604010683 NAD binding site [chemical binding]; other site 713604010684 sugar binding site [chemical binding]; other site 713604010685 divalent metal binding site [ion binding]; other site 713604010686 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604010687 dimer interface [polypeptide binding]; other site 713604010688 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604010689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010690 dimer interface [polypeptide binding]; other site 713604010691 conserved gate region; other site 713604010692 putative PBP binding loops; other site 713604010693 ABC-ATPase subunit interface; other site 713604010694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010695 dimer interface [polypeptide binding]; other site 713604010696 conserved gate region; other site 713604010697 putative PBP binding loops; other site 713604010698 ABC-ATPase subunit interface; other site 713604010699 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604010700 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604010701 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 713604010702 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 713604010703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604010704 putative DNA binding site [nucleotide binding]; other site 713604010705 putative Zn2+ binding site [ion binding]; other site 713604010706 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604010707 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 713604010708 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 713604010709 dimer interface [polypeptide binding]; other site 713604010710 active site 713604010711 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 713604010712 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 713604010713 EamA-like transporter family; Region: EamA; pfam00892 713604010714 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 713604010715 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604010716 ATP binding site [chemical binding]; other site 713604010717 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 713604010718 intersubunit interface [polypeptide binding]; other site 713604010719 active site 713604010720 zinc binding site [ion binding]; other site 713604010721 Na+ binding site [ion binding]; other site 713604010722 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604010723 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604010724 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010725 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010726 putative sugar binding sites [chemical binding]; other site 713604010727 Q-X-W motif; other site 713604010728 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604010729 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010730 acyl-activating enzyme (AAE) consensus motif; other site 713604010731 AMP binding site [chemical binding]; other site 713604010732 active site 713604010733 CoA binding site [chemical binding]; other site 713604010734 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604010735 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604010736 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604010737 active site 713604010738 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604010739 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604010740 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 713604010741 putative NADP binding site [chemical binding]; other site 713604010742 KR domain; Region: KR; pfam08659 713604010743 active site 713604010744 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604010745 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604010746 Cytochrome P450; Region: p450; cl12078 713604010747 Electron transfer DM13; Region: DM13; pfam10517 713604010748 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604010749 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 713604010750 NAD(P) binding site [chemical binding]; other site 713604010751 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604010752 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604010753 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604010754 DNA binding residues [nucleotide binding] 713604010755 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 713604010756 endoglucanase; Region: PLN02308 713604010757 Cellulose binding domain; Region: CBM_3; smart01067 713604010758 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604010759 Interdomain contacts; other site 713604010760 Cytokine receptor motif; other site 713604010761 Cellulose binding domain; Region: CBM_3; pfam00942 713604010762 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 713604010763 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 713604010764 Putative Ig domain; Region: He_PIG; pfam05345 713604010765 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010766 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010767 putative sugar binding sites [chemical binding]; other site 713604010768 Q-X-W motif; other site 713604010769 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 713604010770 active site 713604010771 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604010772 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010773 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010774 putative sugar binding sites [chemical binding]; other site 713604010775 Q-X-W motif; other site 713604010776 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 713604010777 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604010778 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604010779 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604010780 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604010781 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 713604010782 active site 713604010783 substrate binding site [chemical binding]; other site 713604010784 cosubstrate binding site; other site 713604010785 catalytic site [active] 713604010786 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 713604010787 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604010788 substrate binding site [chemical binding]; other site 713604010789 oxyanion hole (OAH) forming residues; other site 713604010790 trimer interface [polypeptide binding]; other site 713604010791 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604010792 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604010793 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604010794 AAA domain; Region: AAA_22; pfam13401 713604010795 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 713604010796 Catalytic site [active] 713604010797 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 713604010798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604010799 Walker A/P-loop; other site 713604010800 ATP binding site [chemical binding]; other site 713604010801 Q-loop/lid; other site 713604010802 ABC transporter signature motif; other site 713604010803 Walker B; other site 713604010804 D-loop; other site 713604010805 H-loop/switch region; other site 713604010806 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604010807 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604010808 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604010809 DNA binding residues [nucleotide binding] 713604010810 acyl-CoA synthetase; Validated; Region: PRK07867 713604010811 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 713604010812 acyl-activating enzyme (AAE) consensus motif; other site 713604010813 putative AMP binding site [chemical binding]; other site 713604010814 putative active site [active] 713604010815 putative CoA binding site [chemical binding]; other site 713604010816 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604010817 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604010818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010819 short chain dehydrogenase; Provisional; Region: PRK06197 713604010820 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 713604010821 putative NAD(P) binding site [chemical binding]; other site 713604010822 active site 713604010823 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 713604010824 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604010825 active site pocket [active] 713604010826 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604010827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010828 dimer interface [polypeptide binding]; other site 713604010829 conserved gate region; other site 713604010830 putative PBP binding loops; other site 713604010831 ABC-ATPase subunit interface; other site 713604010832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604010833 dimer interface [polypeptide binding]; other site 713604010834 conserved gate region; other site 713604010835 putative PBP binding loops; other site 713604010836 ABC-ATPase subunit interface; other site 713604010837 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604010838 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604010839 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604010840 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604010841 DNA-binding site [nucleotide binding]; DNA binding site 713604010842 FCD domain; Region: FCD; pfam07729 713604010843 Domain of unknown function (DUF718); Region: DUF718; pfam05336 713604010844 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604010845 active site 713604010846 TDP-binding site; other site 713604010847 acceptor substrate-binding pocket; other site 713604010848 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604010849 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604010850 active site 713604010851 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604010852 Cytochrome P450; Region: p450; cl12078 713604010853 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 713604010854 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 713604010855 active site 713604010856 iron coordination sites [ion binding]; other site 713604010857 substrate binding pocket [chemical binding]; other site 713604010858 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010859 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604010860 AMP binding site [chemical binding]; other site 713604010861 active site 713604010862 acyl-activating enzyme (AAE) consensus motif; other site 713604010863 CoA binding site [chemical binding]; other site 713604010864 Condensation domain; Region: Condensation; pfam00668 713604010865 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604010866 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604010867 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604010868 acyl-activating enzyme (AAE) consensus motif; other site 713604010869 AMP binding site [chemical binding]; other site 713604010870 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604010871 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604010872 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 713604010873 active site 713604010874 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 713604010875 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604010876 putative NADP binding site [chemical binding]; other site 713604010877 active site 713604010878 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604010879 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 713604010880 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604010881 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604010882 acyl-activating enzyme (AAE) consensus motif; other site 713604010883 AMP binding site [chemical binding]; other site 713604010884 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604010885 short chain dehydrogenase; Provisional; Region: PRK07041 713604010886 classical (c) SDRs; Region: SDR_c; cd05233 713604010887 NAD(P) binding site [chemical binding]; other site 713604010888 active site 713604010889 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010891 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 713604010892 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 713604010893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604010894 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604010895 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604010896 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604010897 hypothetical protein; Validated; Region: PRK05868 713604010898 hypothetical protein; Provisional; Region: PRK07236 713604010899 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604010900 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604010901 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604010902 nucleotide binding site [chemical binding]; other site 713604010903 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604010904 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604010905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604010906 Walker B; other site 713604010907 D-loop; other site 713604010908 H-loop/switch region; other site 713604010909 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604010910 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604010911 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604010912 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604010913 TM-ABC transporter signature motif; other site 713604010914 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 713604010915 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604010916 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604010917 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604010918 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604010919 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604010920 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 713604010921 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604010922 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 713604010923 putative NAD(P) binding site [chemical binding]; other site 713604010924 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 713604010925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010926 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604010927 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604010928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010930 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010931 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010932 putative sugar binding sites [chemical binding]; other site 713604010933 Q-X-W motif; other site 713604010934 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 713604010935 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010936 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010937 putative sugar binding sites [chemical binding]; other site 713604010938 Q-X-W motif; other site 713604010939 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 713604010940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 713604010941 putative sugar binding sites [chemical binding]; other site 713604010942 Q-X-W motif; other site 713604010943 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 713604010944 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 713604010945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010947 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 713604010948 Cellulose binding domain; Region: CBM_2; pfam00553 713604010949 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 713604010950 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010951 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010952 putative sugar binding sites [chemical binding]; other site 713604010953 Q-X-W motif; other site 713604010954 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 713604010955 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010956 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010957 putative sugar binding sites [chemical binding]; other site 713604010958 Q-X-W motif; other site 713604010959 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604010960 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604010961 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604010962 putative sugar binding sites [chemical binding]; other site 713604010963 Q-X-W motif; other site 713604010964 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 713604010965 active site 713604010966 cinnamyl-alcohol dehydrogenase; Region: PLN02514 713604010967 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 713604010968 putative NAD(P) binding site [chemical binding]; other site 713604010969 putative substrate binding site [chemical binding]; other site 713604010970 catalytic Zn binding site [ion binding]; other site 713604010971 structural Zn binding site [ion binding]; other site 713604010972 dimer interface [polypeptide binding]; other site 713604010973 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604010974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604010975 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604010976 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604010977 acyl-activating enzyme (AAE) consensus motif; other site 713604010978 AMP binding site [chemical binding]; other site 713604010979 active site 713604010980 CoA binding site [chemical binding]; other site 713604010981 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604010982 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604010983 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604010984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604010985 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604010986 putative substrate translocation pore; other site 713604010987 Tannase and feruloyl esterase; Region: Tannase; pfam07519 713604010988 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604010989 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 713604010990 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604010991 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604010992 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 713604010993 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604010994 CBD_II domain; Region: CBD_II; smart00637 713604010995 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604010996 acyl carrier protein; Provisional; Region: acpP; PRK00982 713604010997 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 713604010998 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 713604010999 dimer interface [polypeptide binding]; other site 713604011000 active site 713604011001 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 713604011002 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 713604011003 dimer interface [polypeptide binding]; other site 713604011004 active site 713604011005 CoA binding pocket [chemical binding]; other site 713604011006 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 713604011007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 713604011008 active site 713604011009 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604011010 Cytochrome P450; Region: p450; cl12078 713604011011 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604011012 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604011013 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604011014 acyl-activating enzyme (AAE) consensus motif; other site 713604011015 acyl-activating enzyme (AAE) consensus motif; other site 713604011016 AMP binding site [chemical binding]; other site 713604011017 active site 713604011018 CoA binding site [chemical binding]; other site 713604011019 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604011020 extended (e) SDRs; Region: SDR_e; cd08946 713604011021 NAD(P) binding site [chemical binding]; other site 713604011022 active site 713604011023 substrate binding site [chemical binding]; other site 713604011024 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604011025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604011026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604011027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604011028 dimerization interface [polypeptide binding]; other site 713604011029 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604011030 short chain dehydrogenase; Provisional; Region: PRK06523 713604011031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011032 NAD(P) binding site [chemical binding]; other site 713604011033 active site 713604011034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011035 NAD(P) binding site [chemical binding]; other site 713604011036 active site 713604011037 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604011038 MarR family; Region: MarR; pfam01047 713604011039 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604011040 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604011041 NB-ARC domain; Region: NB-ARC; pfam00931 713604011042 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604011043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604011044 binding surface 713604011045 TPR motif; other site 713604011046 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604011047 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604011048 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 713604011049 active site 713604011050 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 713604011051 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 713604011052 dimer interface [polypeptide binding]; other site 713604011053 active site 713604011054 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604011055 catalytic residues [active] 713604011056 substrate binding site [chemical binding]; other site 713604011057 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 713604011058 active site 713604011059 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604011060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604011061 active site 713604011062 phosphorylation site [posttranslational modification] 713604011063 intermolecular recognition site; other site 713604011064 dimerization interface [polypeptide binding]; other site 713604011065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604011066 DNA binding residues [nucleotide binding] 713604011067 dimerization interface [polypeptide binding]; other site 713604011068 Putative sensor; Region: Sensor; pfam13796 713604011069 Histidine kinase; Region: HisKA_3; pfam07730 713604011070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604011071 Mg2+ binding site [ion binding]; other site 713604011072 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604011073 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604011074 Walker A/P-loop; other site 713604011075 ATP binding site [chemical binding]; other site 713604011076 Q-loop/lid; other site 713604011077 ABC transporter signature motif; other site 713604011078 Walker B; other site 713604011079 D-loop; other site 713604011080 H-loop/switch region; other site 713604011081 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 713604011082 FtsX-like permease family; Region: FtsX; pfam02687 713604011083 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 713604011084 FtsX-like permease family; Region: FtsX; pfam02687 713604011085 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 713604011086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604011087 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 713604011088 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 713604011089 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604011090 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604011091 active site 713604011092 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 713604011093 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604011094 dimer interface [polypeptide binding]; other site 713604011095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604011096 catalytic residue [active] 713604011097 Condensation domain; Region: Condensation; pfam00668 713604011098 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604011099 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604011100 acyl-activating enzyme (AAE) consensus motif; other site 713604011101 AMP binding site [chemical binding]; other site 713604011102 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011103 Condensation domain; Region: Condensation; pfam00668 713604011104 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604011105 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604011106 acyl-activating enzyme (AAE) consensus motif; other site 713604011107 AMP binding site [chemical binding]; other site 713604011108 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011109 Condensation domain; Region: Condensation; pfam00668 713604011110 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604011111 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604011112 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604011113 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604011114 active site 713604011115 CoA binding site [chemical binding]; other site 713604011116 AMP binding site [chemical binding]; other site 713604011117 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011118 Thioesterase domain; Region: Thioesterase; pfam00975 713604011119 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604011120 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604011121 MbtH-like protein; Region: MbtH; cl01279 713604011122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604011123 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604011124 Walker A/P-loop; other site 713604011125 ATP binding site [chemical binding]; other site 713604011126 Q-loop/lid; other site 713604011127 ABC transporter signature motif; other site 713604011128 Walker B; other site 713604011129 D-loop; other site 713604011130 H-loop/switch region; other site 713604011131 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 713604011132 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604011133 dimer interface [polypeptide binding]; other site 713604011134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604011135 catalytic residue [active] 713604011136 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 713604011137 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 713604011138 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604011139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011140 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 713604011141 NAD(P) binding site [chemical binding]; other site 713604011142 active site 713604011143 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 713604011144 active site 713604011145 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 713604011146 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 713604011147 dimer interface [polypeptide binding]; other site 713604011148 active site 713604011149 acyl carrier protein; Provisional; Region: acpP; PRK00982 713604011150 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604011151 DNA binding site [nucleotide binding] 713604011152 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604011153 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636 713604011154 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 713604011155 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 713604011156 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 713604011157 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 713604011158 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604011159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604011160 dimerization interface [polypeptide binding]; other site 713604011161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604011162 dimer interface [polypeptide binding]; other site 713604011163 phosphorylation site [posttranslational modification] 713604011164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604011165 ATP binding site [chemical binding]; other site 713604011166 Mg2+ binding site [ion binding]; other site 713604011167 G-X-G motif; other site 713604011168 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604011169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604011170 active site 713604011171 phosphorylation site [posttranslational modification] 713604011172 intermolecular recognition site; other site 713604011173 dimerization interface [polypeptide binding]; other site 713604011174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604011175 DNA binding site [nucleotide binding] 713604011176 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604011177 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604011178 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 713604011179 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 713604011180 active site 713604011181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604011182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604011183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604011184 dimerization interface [polypeptide binding]; other site 713604011185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011186 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604011187 NAD(P) binding site [chemical binding]; other site 713604011188 active site 713604011189 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604011190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604011191 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604011192 putative substrate translocation pore; other site 713604011193 PaaX-like protein; Region: PaaX; pfam07848 713604011194 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 713604011195 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 713604011196 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 713604011197 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604011198 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604011199 FkbH-like domain; Region: FkbH; TIGR01686 713604011200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604011201 active site 713604011202 motif I; other site 713604011203 motif II; other site 713604011204 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604011205 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604011206 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604011207 active site 713604011208 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011209 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604011210 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604011211 acyl-activating enzyme (AAE) consensus motif; other site 713604011212 AMP binding site [chemical binding]; other site 713604011213 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011214 Condensation domain; Region: Condensation; pfam00668 713604011215 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604011216 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604011217 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 713604011218 acyl-activating enzyme (AAE) consensus motif; other site 713604011219 AMP binding site [chemical binding]; other site 713604011220 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011221 Condensation domain; Region: Condensation; pfam00668 713604011222 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604011223 Condensation domain; Region: Condensation; pfam00668 713604011224 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604011225 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604011226 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011227 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604011228 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 713604011229 active site 713604011230 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011231 Condensation domain; Region: Condensation; pfam00668 713604011232 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604011233 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604011234 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604011235 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604011236 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 713604011237 active site 713604011238 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 713604011239 metal ion-dependent adhesion site (MIDAS); other site 713604011240 Calx-beta domain; Region: Calx-beta; pfam03160 713604011241 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 713604011242 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 713604011243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604011244 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 713604011245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604011246 S-adenosylmethionine binding site [chemical binding]; other site 713604011247 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 713604011248 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 713604011249 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 713604011250 active site lid residues [active] 713604011251 substrate binding pocket [chemical binding]; other site 713604011252 catalytic residues [active] 713604011253 substrate-Mg2+ binding site; other site 713604011254 aspartate-rich region 1; other site 713604011255 aspartate-rich region 2; other site 713604011256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604011257 phytoene desaturase; Region: crtI_fam; TIGR02734 713604011258 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 713604011259 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 713604011260 substrate binding pocket [chemical binding]; other site 713604011261 chain length determination region; other site 713604011262 substrate-Mg2+ binding site; other site 713604011263 catalytic residues [active] 713604011264 aspartate-rich region 1; other site 713604011265 active site lid residues [active] 713604011266 aspartate-rich region 2; other site 713604011267 Protein of unknown function (DUF422); Region: DUF422; cl00991 713604011268 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 713604011269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 713604011270 active site 713604011271 phytoene desaturase; Region: crtI_fam; TIGR02734 713604011272 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 713604011273 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 713604011274 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604011275 DNA binding residues [nucleotide binding] 713604011276 B12 binding domain; Region: B12-binding_2; cl03653 713604011277 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 713604011278 B12 binding site [chemical binding]; other site 713604011279 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604011280 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 713604011281 DNA binding residues [nucleotide binding] 713604011282 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 713604011283 iron-sulfur cluster [ion binding]; other site 713604011284 [2Fe-2S] cluster binding site [ion binding]; other site 713604011285 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604011286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604011287 dimer interface [polypeptide binding]; other site 713604011288 conserved gate region; other site 713604011289 putative PBP binding loops; other site 713604011290 ABC-ATPase subunit interface; other site 713604011291 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 713604011292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604011293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604011294 dimer interface [polypeptide binding]; other site 713604011295 ABC-ATPase subunit interface; other site 713604011296 putative PBP binding loops; other site 713604011297 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604011298 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604011299 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604011300 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604011301 DNA binding site [nucleotide binding] 713604011302 domain linker motif; other site 713604011303 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604011304 dimerization interface [polypeptide binding]; other site 713604011305 ligand binding site [chemical binding]; other site 713604011306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604011307 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604011308 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604011309 Cellulose binding domain; Region: CBM_2; pfam00553 713604011310 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604011311 TIGR03086 family protein; Region: TIGR03086 713604011312 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604011313 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 713604011314 putative hydrophobic ligand binding site [chemical binding]; other site 713604011315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604011316 dimerization interface [polypeptide binding]; other site 713604011317 putative DNA binding site [nucleotide binding]; other site 713604011318 putative Zn2+ binding site [ion binding]; other site 713604011319 Cellulose binding domain; Region: CBM_2; pfam00553 713604011320 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604011321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011322 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 713604011323 NAD(P) binding site [chemical binding]; other site 713604011324 active site 713604011325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604011326 PAS fold; Region: PAS_3; pfam08447 713604011327 putative active site [active] 713604011328 heme pocket [chemical binding]; other site 713604011329 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604011330 GAF domain; Region: GAF; pfam01590 713604011331 PAS domain S-box; Region: sensory_box; TIGR00229 713604011332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604011333 putative active site [active] 713604011334 heme pocket [chemical binding]; other site 713604011335 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604011336 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604011337 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604011338 ATP binding site [chemical binding]; other site 713604011339 Mg2+ binding site [ion binding]; other site 713604011340 G-X-G motif; other site 713604011341 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604011342 regulatory phosphorylation site [posttranslational modification]; other site 713604011343 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604011344 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604011345 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 713604011346 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 713604011347 Alginate lyase; Region: Alginate_lyase2; pfam08787 713604011348 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 713604011349 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 713604011350 dimer interface [polypeptide binding]; other site 713604011351 active site 713604011352 heme binding site [chemical binding]; other site 713604011353 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 713604011354 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 713604011355 metal binding site 2 [ion binding]; metal-binding site 713604011356 putative DNA binding helix; other site 713604011357 metal binding site 1 [ion binding]; metal-binding site 713604011358 dimer interface [polypeptide binding]; other site 713604011359 structural Zn2+ binding site [ion binding]; other site 713604011360 thymidylate synthase; Reviewed; Region: thyA; PRK01827 713604011361 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 713604011362 dimerization interface [polypeptide binding]; other site 713604011363 active site 713604011364 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604011365 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 713604011366 folate binding site [chemical binding]; other site 713604011367 NADP+ binding site [chemical binding]; other site 713604011368 choline dehydrogenase; Region: betA; TIGR01810 713604011369 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604011370 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 713604011371 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 713604011372 NAD(P) binding site [chemical binding]; other site 713604011373 catalytic residues [active] 713604011374 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 713604011375 catalytic site [active] 713604011376 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 713604011377 PLD-like domain; Region: PLDc_2; pfam13091 713604011378 putative active site [active] 713604011379 catalytic site [active] 713604011380 NACHT domain; Region: NACHT; pfam05729 713604011381 AAA ATPase domain; Region: AAA_16; pfam13191 713604011382 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 713604011383 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 713604011384 FMN-binding pocket [chemical binding]; other site 713604011385 flavin binding motif; other site 713604011386 phosphate binding motif [ion binding]; other site 713604011387 beta-alpha-beta structure motif; other site 713604011388 NAD binding pocket [chemical binding]; other site 713604011389 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604011390 catalytic loop [active] 713604011391 iron binding site [ion binding]; other site 713604011392 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 713604011393 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 713604011394 iron-sulfur cluster [ion binding]; other site 713604011395 [2Fe-2S] cluster binding site [ion binding]; other site 713604011396 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604011397 hydrophobic ligand binding site; other site 713604011398 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604011399 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604011400 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604011401 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 713604011402 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 713604011403 homodimer interface [polypeptide binding]; other site 713604011404 putative substrate binding pocket [chemical binding]; other site 713604011405 diiron center [ion binding]; other site 713604011406 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 713604011407 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 713604011408 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 713604011409 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 713604011410 RNase_H superfamily; Region: RNase_H_2; pfam13482 713604011411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604011412 AAA domain; Region: AAA_11; pfam13086 713604011413 Walker A motif; other site 713604011414 ATP binding site [chemical binding]; other site 713604011415 AAA domain; Region: AAA_12; pfam13087 713604011416 short chain dehydrogenase; Provisional; Region: PRK07109 713604011417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011418 NAD(P) binding site [chemical binding]; other site 713604011419 active site 713604011420 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 713604011421 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604011422 putative metal binding site [ion binding]; other site 713604011423 ChaB; Region: ChaB; pfam06150 713604011424 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 713604011425 CheB methylesterase; Region: CheB_methylest; pfam01339 713604011426 CheB methylesterase; Region: CheB_methylest; pfam01339 713604011427 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604011428 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604011429 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 713604011430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604011431 S-adenosylmethionine binding site [chemical binding]; other site 713604011432 PAS fold; Region: PAS; pfam00989 713604011433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 713604011434 putative active site [active] 713604011435 heme pocket [chemical binding]; other site 713604011436 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604011437 PAS domain; Region: PAS_9; pfam13426 713604011438 putative active site [active] 713604011439 heme pocket [chemical binding]; other site 713604011440 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604011441 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 713604011442 active site 713604011443 HIGH motif; other site 713604011444 nucleotide binding site [chemical binding]; other site 713604011445 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604011446 active site 713604011447 KMSKS motif; other site 713604011448 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 713604011449 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604011450 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604011451 ATP binding site [chemical binding]; other site 713604011452 Mg2+ binding site [ion binding]; other site 713604011453 G-X-G motif; other site 713604011454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604011455 putative substrate translocation pore; other site 713604011456 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 713604011457 Uncharacterized conserved protein [Function unknown]; Region: COG4198 713604011458 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 713604011459 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604011460 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 713604011461 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 713604011462 active site 713604011463 DNA binding site [nucleotide binding] 713604011464 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 713604011465 DNA binding site [nucleotide binding] 713604011466 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 713604011467 nucleotide binding site [chemical binding]; other site 713604011468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604011469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604011470 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 713604011471 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 713604011472 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 713604011473 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 713604011474 active site 713604011475 dimer interface [polypeptide binding]; other site 713604011476 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 713604011477 putative sialic acid transporter; Region: 2A0112; TIGR00891 713604011478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604011479 putative substrate translocation pore; other site 713604011480 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 713604011481 catalytic site [active] 713604011482 BNR repeat-like domain; Region: BNR_2; pfam13088 713604011483 Asp-box motif; other site 713604011484 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 713604011485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604011486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604011487 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 713604011488 putative dimerization interface [polypeptide binding]; other site 713604011489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604011490 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604011491 dimerization interface [polypeptide binding]; other site 713604011492 substrate binding pocket [chemical binding]; other site 713604011493 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 713604011494 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604011495 putative NAD(P) binding site [chemical binding]; other site 713604011496 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604011497 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604011498 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604011499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604011500 S-adenosylmethionine binding site [chemical binding]; other site 713604011501 Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226 713604011502 putative active site [active] 713604011503 Zn binding site [ion binding]; other site 713604011504 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 713604011505 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604011506 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604011507 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 713604011508 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604011509 carboxyltransferase (CT) interaction site; other site 713604011510 biotinylation site [posttranslational modification]; other site 713604011511 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 713604011512 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 713604011513 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 713604011514 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 713604011515 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 713604011516 active site 713604011517 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604011518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604011519 DNA-binding site [nucleotide binding]; DNA binding site 713604011520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604011521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604011522 homodimer interface [polypeptide binding]; other site 713604011523 catalytic residue [active] 713604011524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604011525 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604011526 putative substrate translocation pore; other site 713604011527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604011528 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604011529 hydrophobic ligand binding site; other site 713604011530 Bifunctional nuclease; Region: DNase-RNase; pfam02577 713604011531 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604011532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604011533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604011534 DNA binding residues [nucleotide binding] 713604011535 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604011536 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 713604011537 acyl-CoA synthetase; Validated; Region: PRK05850 713604011538 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604011539 acyl-activating enzyme (AAE) consensus motif; other site 713604011540 active site 713604011541 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 713604011542 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604011543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604011544 S-adenosylmethionine binding site [chemical binding]; other site 713604011545 Hemerythrin-like domain; Region: Hr-like; cd12108 713604011546 Fe binding site [ion binding]; other site 713604011547 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 713604011548 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 713604011549 nucleotide binding site [chemical binding]; other site 713604011550 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604011551 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604011552 substrate binding site [chemical binding]; other site 713604011553 ATP binding site [chemical binding]; other site 713604011554 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 713604011555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604011556 ATP binding site [chemical binding]; other site 713604011557 putative Mg++ binding site [ion binding]; other site 713604011558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604011559 nucleotide binding region [chemical binding]; other site 713604011560 ATP-binding site [chemical binding]; other site 713604011561 ANTAR domain; Region: ANTAR; pfam03861 713604011562 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604011563 anti sigma factor interaction site; other site 713604011564 regulatory phosphorylation site [posttranslational modification]; other site 713604011565 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604011566 GAF domain; Region: GAF; pfam01590 713604011567 GAF domain; Region: GAF_2; pfam13185 713604011568 ANTAR domain; Region: ANTAR; pfam03861 713604011569 GAF domain; Region: GAF; pfam01590 713604011570 GAF domain; Region: GAF_2; pfam13185 713604011571 ANTAR domain; Region: ANTAR; pfam03861 713604011572 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 713604011573 nucleotide binding site [chemical binding]; other site 713604011574 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604011575 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 713604011576 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604011577 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604011578 substrate binding pocket [chemical binding]; other site 713604011579 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604011580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604011581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604011582 DoxX-like family; Region: DoxX_2; pfam13564 713604011583 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604011584 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 713604011585 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 713604011586 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604011587 iron-sulfur cluster [ion binding]; other site 713604011588 [2Fe-2S] cluster binding site [ion binding]; other site 713604011589 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 713604011590 NAD-dependent deacetylase; Provisional; Region: PRK05333 713604011591 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 713604011592 NAD+ binding site [chemical binding]; other site 713604011593 substrate binding site [chemical binding]; other site 713604011594 Zn binding site [ion binding]; other site 713604011595 TIGR03086 family protein; Region: TIGR03086 713604011596 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 713604011597 heme-binding site [chemical binding]; other site 713604011598 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 713604011599 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 713604011600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604011601 non-specific DNA binding site [nucleotide binding]; other site 713604011602 salt bridge; other site 713604011603 sequence-specific DNA binding site [nucleotide binding]; other site 713604011604 Cupin domain; Region: Cupin_2; pfam07883 713604011605 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 713604011606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604011607 Coenzyme A binding pocket [chemical binding]; other site 713604011608 Cupin domain; Region: Cupin_2; pfam07883 713604011609 elongation factor Tu; Reviewed; Region: PRK12736 713604011610 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 713604011611 G1 box; other site 713604011612 GEF interaction site [polypeptide binding]; other site 713604011613 GTP/Mg2+ binding site [chemical binding]; other site 713604011614 Switch I region; other site 713604011615 G2 box; other site 713604011616 G3 box; other site 713604011617 Switch II region; other site 713604011618 G4 box; other site 713604011619 G5 box; other site 713604011620 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 713604011621 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 713604011622 Antibiotic Binding Site [chemical binding]; other site 713604011623 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 713604011624 Right handed beta helix region; Region: Beta_helix; pfam13229 713604011625 acetaldehyde dehydrogenase; Validated; Region: PRK08300 713604011626 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 713604011627 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 713604011628 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 713604011629 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 713604011630 active site 713604011631 catalytic residues [active] 713604011632 metal binding site [ion binding]; metal-binding site 713604011633 DmpG-like communication domain; Region: DmpG_comm; pfam07836 713604011634 hypothetical protein; Provisional; Region: PRK07236 713604011635 hypothetical protein; Provisional; Region: PRK06834 713604011636 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604011637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604011638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604011639 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 713604011640 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 713604011641 Amidase; Region: Amidase; cl11426 713604011642 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604011643 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604011644 LysE type translocator; Region: LysE; cl00565 713604011645 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 713604011646 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 713604011647 DNA binding site [nucleotide binding] 713604011648 active site 713604011649 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 713604011650 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 713604011651 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 713604011652 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 713604011653 DNA binding site [nucleotide binding] 713604011654 active site 713604011655 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604011656 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604011657 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604011658 DNA binding residues [nucleotide binding] 713604011659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604011660 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 713604011661 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604011662 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 713604011663 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604011664 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604011665 putative DNA binding site [nucleotide binding]; other site 713604011666 putative Zn2+ binding site [ion binding]; other site 713604011667 AsnC family; Region: AsnC_trans_reg; pfam01037 713604011668 hypothetical protein; Provisional; Region: PRK06541 713604011669 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604011670 inhibitor-cofactor binding pocket; inhibition site 713604011671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604011672 catalytic residue [active] 713604011673 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604011674 Cytochrome P450; Region: p450; cl12078 713604011675 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604011676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604011677 DNA binding residues [nucleotide binding] 713604011678 dimerization interface [polypeptide binding]; other site 713604011679 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604011680 active site 713604011681 catalytic triad [active] 713604011682 calcium binding site [ion binding]; other site 713604011683 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604011684 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604011685 active site 713604011686 ATP binding site [chemical binding]; other site 713604011687 substrate binding site [chemical binding]; other site 713604011688 activation loop (A-loop); other site 713604011689 CBD_II domain; Region: CBD_II; smart00637 713604011690 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 713604011691 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604011692 active site 713604011693 heat shock protein 90; Provisional; Region: PRK05218 713604011694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604011695 ATP binding site [chemical binding]; other site 713604011696 Mg2+ binding site [ion binding]; other site 713604011697 G-X-G motif; other site 713604011698 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 713604011699 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 713604011700 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 713604011701 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 713604011702 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 713604011703 CopC domain; Region: CopC; pfam04234 713604011704 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 713604011705 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604011706 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604011707 DNA binding residues [nucleotide binding] 713604011708 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604011709 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604011710 active site 713604011711 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 713604011712 oxidoreductase; Provisional; Region: PRK12743 713604011713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011714 NAD(P) binding site [chemical binding]; other site 713604011715 active site 713604011716 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 713604011717 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 713604011718 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 713604011719 putative active site [active] 713604011720 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604011721 active site 713604011722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604011723 active site 713604011724 motif I; other site 713604011725 motif II; other site 713604011726 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 713604011727 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604011728 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604011729 NAD(P) binding site [chemical binding]; other site 713604011730 catalytic residues [active] 713604011731 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 713604011732 translation initiation factor IF-2 subunit beta; Provisional; Region: PRK12336 713604011733 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604011734 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 713604011735 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604011736 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 713604011737 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 713604011738 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 713604011739 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 713604011740 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 713604011741 putative active site [active] 713604011742 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604011743 classical (c) SDRs; Region: SDR_c; cd05233 713604011744 NAD(P) binding site [chemical binding]; other site 713604011745 active site 713604011746 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604011747 substrate binding site [chemical binding]; other site 713604011748 ATP binding site [chemical binding]; other site 713604011749 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604011750 active site 713604011751 HIGH motif; other site 713604011752 nucleotide binding site [chemical binding]; other site 713604011753 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 713604011754 dimer interface [polypeptide binding]; other site 713604011755 active site 713604011756 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 713604011757 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 713604011758 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604011759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011760 NAD(P) binding site [chemical binding]; other site 713604011761 active site 713604011762 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 713604011763 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604011764 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604011765 active site 713604011766 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604011767 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604011768 active site 713604011769 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 713604011770 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 713604011771 putative ADP-binding pocket [chemical binding]; other site 713604011772 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604011773 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604011774 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 713604011775 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 713604011776 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 713604011777 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604011778 NAD binding site [chemical binding]; other site 713604011779 catalytic Zn binding site [ion binding]; other site 713604011780 structural Zn binding site [ion binding]; other site 713604011781 Predicted acyl esterases [General function prediction only]; Region: COG2936 713604011782 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604011783 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604011784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604011785 NAD(P) binding site [chemical binding]; other site 713604011786 active site 713604011787 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 713604011788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604011789 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604011790 hydrophobic ligand binding site; other site 713604011791 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 713604011792 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604011793 active site 713604011794 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604011795 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 713604011796 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 713604011797 active site 713604011798 DNA binding site [nucleotide binding] 713604011799 Int/Topo IB signature motif; other site 713604011800 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 713604011801 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 713604011802 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 713604011803 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 713604011804 [2Fe-2S] cluster binding site [ion binding]; other site 713604011805 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604011806 putative methyltransferase; Provisional; Region: PRK14967 713604011807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604011808 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 713604011809 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604011810 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 713604011811 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604011812 anti sigma factor interaction site; other site 713604011813 regulatory phosphorylation site [posttranslational modification]; other site 713604011814 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604011815 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 713604011816 Hemerythrin-like domain; Region: Hr-like; cd12108 713604011817 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 713604011818 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604011819 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604011820 catalytic residue [active] 713604011821 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 713604011822 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 713604011823 amidohydrolase; Region: amidohydrolases; TIGR01891 713604011824 metal binding site [ion binding]; metal-binding site 713604011825 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 713604011826 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 713604011827 substrate binding pocket [chemical binding]; other site 713604011828 active site 713604011829 iron coordination sites [ion binding]; other site 713604011830 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 713604011831 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 713604011832 active site 713604011833 non-prolyl cis peptide bond; other site 713604011834 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604011835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604011836 putative PBP binding loops; other site 713604011837 dimer interface [polypeptide binding]; other site 713604011838 ABC-ATPase subunit interface; other site 713604011839 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604011840 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604011841 Walker A/P-loop; other site 713604011842 ATP binding site [chemical binding]; other site 713604011843 Q-loop/lid; other site 713604011844 ABC transporter signature motif; other site 713604011845 Walker B; other site 713604011846 D-loop; other site 713604011847 H-loop/switch region; other site 713604011848 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 713604011849 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 713604011850 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604011851 membrane-bound complex binding site; other site 713604011852 hinge residues; other site 713604011853 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604011854 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604011855 HTH domain; Region: HTH_11; pfam08279 713604011856 WYL domain; Region: WYL; pfam13280 713604011857 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604011858 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604011859 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604011860 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604011861 Predicted ATPase [General function prediction only]; Region: COG3903 713604011862 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604011863 hypothetical protein; Validated; Region: PRK05868 713604011864 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 713604011865 nucleotide binding site/active site [active] 713604011866 HIT family signature motif; other site 713604011867 catalytic residue [active] 713604011868 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604011869 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 713604011870 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 713604011871 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604011872 MarR family; Region: MarR; pfam01047 713604011873 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 713604011874 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 713604011875 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 713604011876 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 713604011877 dinuclear metal binding motif [ion binding]; other site 713604011878 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 713604011879 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604011880 catalytic loop [active] 713604011881 iron binding site [ion binding]; other site 713604011882 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 713604011883 FAD binding pocket [chemical binding]; other site 713604011884 conserved FAD binding motif [chemical binding]; other site 713604011885 phosphate binding motif [ion binding]; other site 713604011886 beta-alpha-beta structure motif; other site 713604011887 NAD binding pocket [chemical binding]; other site 713604011888 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 713604011889 dimerization interface [polypeptide binding]; other site 713604011890 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 713604011891 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 713604011892 active site 713604011893 Domain of unknown function DUF59; Region: DUF59; pfam01883 713604011894 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 713604011895 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 713604011896 NAD binding site [chemical binding]; other site 713604011897 substrate binding site [chemical binding]; other site 713604011898 catalytic Zn binding site [ion binding]; other site 713604011899 structural Zn binding site [ion binding]; other site 713604011900 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 713604011901 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 713604011902 ring oligomerisation interface [polypeptide binding]; other site 713604011903 ATP/Mg binding site [chemical binding]; other site 713604011904 stacking interactions; other site 713604011905 hinge regions; other site 713604011906 TIR domain; Region: TIR_2; pfam13676 713604011907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604011908 non-specific DNA binding site [nucleotide binding]; other site 713604011909 salt bridge; other site 713604011910 sequence-specific DNA binding site [nucleotide binding]; other site 713604011911 AAA ATPase domain; Region: AAA_16; pfam13191 713604011912 NB-ARC domain; Region: NB-ARC; pfam00931 713604011913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604011914 binding surface 713604011915 TPR motif; other site 713604011916 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604011917 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604011918 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604011919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604011920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604011921 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604011922 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604011923 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604011924 classical (c) SDRs; Region: SDR_c; cd05233 713604011925 NAD(P) binding site [chemical binding]; other site 713604011926 active site 713604011927 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 713604011928 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604011929 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 713604011930 putative dimer interface [polypeptide binding]; other site 713604011931 N-terminal domain interface [polypeptide binding]; other site 713604011932 putative substrate binding pocket (H-site) [chemical binding]; other site 713604011933 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604011934 MarR family; Region: MarR_2; pfam12802 713604011935 Uncharacterized conserved protein [Function unknown]; Region: COG2353 713604011936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604011937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604011938 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 713604011939 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 713604011940 alpha-glucosidase; Provisional; Region: PRK10426 713604011941 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 713604011942 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 713604011943 putative active site [active] 713604011944 putative catalytic site [active] 713604011945 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604011946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604011947 dimer interface [polypeptide binding]; other site 713604011948 conserved gate region; other site 713604011949 putative PBP binding loops; other site 713604011950 ABC-ATPase subunit interface; other site 713604011951 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604011952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604011953 putative PBP binding loops; other site 713604011954 dimer interface [polypeptide binding]; other site 713604011955 ABC-ATPase subunit interface; other site 713604011956 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604011957 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604011958 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604011959 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604011960 DNA binding site [nucleotide binding] 713604011961 domain linker motif; other site 713604011962 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604011963 dimerization interface [polypeptide binding]; other site 713604011964 ligand binding site [chemical binding]; other site 713604011965 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604011966 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604011967 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 713604011968 ligand binding site [chemical binding]; other site 713604011969 metal binding site [ion binding]; metal-binding site 713604011970 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604011971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604011972 S-adenosylmethionine binding site [chemical binding]; other site 713604011973 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604011974 Cytochrome P450; Region: p450; cl12078 713604011975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604011976 PAS domain; Region: PAS_9; pfam13426 713604011977 putative active site [active] 713604011978 heme pocket [chemical binding]; other site 713604011979 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604011980 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604011981 metal binding site [ion binding]; metal-binding site 713604011982 active site 713604011983 I-site; other site 713604011984 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604011985 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 713604011986 putative FMN binding site [chemical binding]; other site 713604011987 putative dimer interface [polypeptide binding]; other site 713604011988 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 713604011989 4Fe-4S binding domain; Region: Fer4; pfam00037 713604011990 Cysteine-rich domain; Region: CCG; pfam02754 713604011991 Cysteine-rich domain; Region: CCG; pfam02754 713604011992 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 713604011993 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 713604011994 phosphopeptide binding site; other site 713604011995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604011996 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604011997 putative substrate translocation pore; other site 713604011998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604011999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604012000 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 713604012001 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 713604012002 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 713604012003 shikimate binding site; other site 713604012004 NAD(P) binding site [chemical binding]; other site 713604012005 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604012006 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 713604012007 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604012008 active site 713604012009 metal binding site [ion binding]; metal-binding site 713604012010 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604012011 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604012012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012013 dimer interface [polypeptide binding]; other site 713604012014 conserved gate region; other site 713604012015 putative PBP binding loops; other site 713604012016 ABC-ATPase subunit interface; other site 713604012017 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604012018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012019 dimer interface [polypeptide binding]; other site 713604012020 conserved gate region; other site 713604012021 putative PBP binding loops; other site 713604012022 ABC-ATPase subunit interface; other site 713604012023 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604012024 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 713604012025 AAA ATPase domain; Region: AAA_16; pfam13191 713604012026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604012027 binding surface 713604012028 TPR repeat; Region: TPR_11; pfam13414 713604012029 TPR motif; other site 713604012030 TPR repeat; Region: TPR_11; pfam13414 713604012031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604012032 TPR motif; other site 713604012033 binding surface 713604012034 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 713604012035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604012036 binding surface 713604012037 TPR motif; other site 713604012038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604012039 binding surface 713604012040 TPR motif; other site 713604012041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604012042 binding surface 713604012043 TPR motif; other site 713604012044 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 713604012045 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 713604012046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604012048 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 713604012049 YcaO-like family; Region: YcaO; pfam02624 713604012050 Protein of unknown function (DUF419); Region: DUF419; cl15265 713604012051 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604012052 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604012053 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 713604012054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604012055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604012056 DNA binding residues [nucleotide binding] 713604012057 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604012058 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604012059 Histidine kinase; Region: HisKA_3; pfam07730 713604012060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604012061 Mg2+ binding site [ion binding]; other site 713604012062 G-X-G motif; other site 713604012063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604012064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604012065 active site 713604012066 phosphorylation site [posttranslational modification] 713604012067 intermolecular recognition site; other site 713604012068 dimerization interface [polypeptide binding]; other site 713604012069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604012070 DNA binding residues [nucleotide binding] 713604012071 dimerization interface [polypeptide binding]; other site 713604012072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604012073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604012074 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604012075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604012076 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 713604012077 GTP cyclohydrolase I; Provisional; Region: PLN03044 713604012078 active site 713604012079 Predicted transcriptional regulator [Transcription]; Region: COG2345 713604012080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604012081 putative DNA binding site [nucleotide binding]; other site 713604012082 putative Zn2+ binding site [ion binding]; other site 713604012083 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012084 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012085 DNA binding site [nucleotide binding] 713604012086 domain linker motif; other site 713604012087 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 713604012088 ligand binding site [chemical binding]; other site 713604012089 dimerization interface (open form) [polypeptide binding]; other site 713604012090 dimerization interface (closed form) [polypeptide binding]; other site 713604012091 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 713604012092 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 713604012093 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 713604012094 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 713604012095 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 713604012096 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 713604012097 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604012098 classical (c) SDRs; Region: SDR_c; cd05233 713604012099 NAD(P) binding site [chemical binding]; other site 713604012100 active site 713604012101 Cellulose binding domain; Region: CBM_2; pfam00553 713604012102 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 713604012103 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 713604012104 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 713604012105 putative catalytic site [active] 713604012106 putative metal binding site [ion binding]; other site 713604012107 putative phosphate binding site [ion binding]; other site 713604012108 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012109 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012110 DNA binding site [nucleotide binding] 713604012111 domain linker motif; other site 713604012112 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 713604012113 ligand binding site [chemical binding]; other site 713604012114 dimerization interface (open form) [polypeptide binding]; other site 713604012115 dimerization interface (closed form) [polypeptide binding]; other site 713604012116 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 713604012117 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604012118 putative ligand binding site [chemical binding]; other site 713604012119 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 713604012120 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604012121 Walker A/P-loop; other site 713604012122 ATP binding site [chemical binding]; other site 713604012123 Q-loop/lid; other site 713604012124 ABC transporter signature motif; other site 713604012125 Walker B; other site 713604012126 D-loop; other site 713604012127 H-loop/switch region; other site 713604012128 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604012129 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012130 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012131 TM-ABC transporter signature motif; other site 713604012132 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012133 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012134 TM-ABC transporter signature motif; other site 713604012135 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604012136 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604012137 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604012138 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 713604012139 ribulokinase; Provisional; Region: PRK04123 713604012140 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604012141 nucleotide binding site [chemical binding]; other site 713604012142 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 713604012143 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 713604012144 intersubunit interface [polypeptide binding]; other site 713604012145 active site 713604012146 Zn2+ binding site [ion binding]; other site 713604012147 L-arabinose isomerase; Provisional; Region: PRK02929 713604012148 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 713604012149 hexamer (dimer of trimers) interface [polypeptide binding]; other site 713604012150 trimer interface [polypeptide binding]; other site 713604012151 substrate binding site [chemical binding]; other site 713604012152 Mn binding site [ion binding]; other site 713604012153 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 713604012154 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 713604012155 putative ligand binding site [chemical binding]; other site 713604012156 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 713604012157 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604012158 Walker A/P-loop; other site 713604012159 ATP binding site [chemical binding]; other site 713604012160 Q-loop/lid; other site 713604012161 ABC transporter signature motif; other site 713604012162 Walker B; other site 713604012163 D-loop; other site 713604012164 H-loop/switch region; other site 713604012165 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604012166 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012167 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012168 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012169 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012170 TM-ABC transporter signature motif; other site 713604012171 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604012172 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604012173 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012174 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 713604012175 ligand binding site [chemical binding]; other site 713604012176 dimerization interface (open form) [polypeptide binding]; other site 713604012177 dimerization interface (closed form) [polypeptide binding]; other site 713604012178 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604012179 Cytochrome P450; Region: p450; cl12078 713604012180 glycerol kinase; Provisional; Region: glpK; PRK00047 713604012181 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 713604012182 N- and C-terminal domain interface [polypeptide binding]; other site 713604012183 active site 713604012184 MgATP binding site [chemical binding]; other site 713604012185 catalytic site [active] 713604012186 metal binding site [ion binding]; metal-binding site 713604012187 putative homotetramer interface [polypeptide binding]; other site 713604012188 glycerol binding site [chemical binding]; other site 713604012189 homodimer interface [polypeptide binding]; other site 713604012190 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 713604012191 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604012192 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604012193 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604012194 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 713604012195 amphipathic channel; other site 713604012196 Asn-Pro-Ala signature motifs; other site 713604012197 glycerol kinase; Provisional; Region: glpK; PRK00047 713604012198 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 713604012199 N- and C-terminal domain interface [polypeptide binding]; other site 713604012200 active site 713604012201 MgATP binding site [chemical binding]; other site 713604012202 catalytic site [active] 713604012203 metal binding site [ion binding]; metal-binding site 713604012204 putative homotetramer interface [polypeptide binding]; other site 713604012205 glycerol binding site [chemical binding]; other site 713604012206 homodimer interface [polypeptide binding]; other site 713604012207 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 713604012208 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604012209 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604012210 Phosphotransferase enzyme family; Region: APH; pfam01636 713604012211 active site 713604012212 substrate binding site [chemical binding]; other site 713604012213 ATP binding site [chemical binding]; other site 713604012214 argininosuccinate synthase; Validated; Region: PRK05370 713604012215 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 713604012216 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604012217 putative NAD(P) binding site [chemical binding]; other site 713604012218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604012219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604012220 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604012221 DNA binding site [nucleotide binding] 713604012222 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604012223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604012224 AAA domain; Region: AAA_22; pfam13401 713604012225 Walker A motif; other site 713604012226 ATP binding site [chemical binding]; other site 713604012227 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604012228 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604012229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604012230 binding surface 713604012231 TPR motif; other site 713604012232 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 713604012233 putative active site [active] 713604012234 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604012235 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604012236 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604012237 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604012238 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604012239 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604012240 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 713604012241 FAD binding domain; Region: FAD_binding_4; pfam01565 713604012242 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 713604012243 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012245 DNA binding site [nucleotide binding] 713604012246 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604012247 ligand binding site [chemical binding]; other site 713604012248 dimerization interface [polypeptide binding]; other site 713604012249 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604012250 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604012251 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604012252 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604012253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604012254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012255 dimer interface [polypeptide binding]; other site 713604012256 putative PBP binding loops; other site 713604012257 ABC-ATPase subunit interface; other site 713604012258 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604012259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012260 dimer interface [polypeptide binding]; other site 713604012261 conserved gate region; other site 713604012262 putative PBP binding loops; other site 713604012263 ABC-ATPase subunit interface; other site 713604012264 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604012265 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604012266 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604012267 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604012268 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604012269 Methane oxygenase PmoA; Region: PmoA; pfam14100 713604012270 Amb_all domain; Region: Amb_all; smart00656 713604012271 Pectate lyase; Region: Pectate_lyase; pfam03211 713604012272 Pectinesterase; Region: Pectinesterase; pfam01095 713604012273 putative pectinesterase; Region: PLN02432; cl01911 713604012274 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 713604012275 substrate binding site [chemical binding]; other site 713604012276 active site 713604012277 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 713604012278 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 713604012279 Beta-galactosidase, domain 2; Region: BetaGal_dom2; pfam10435 713604012280 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 713604012281 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 713604012282 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 713604012283 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604012284 anti sigma factor interaction site; other site 713604012285 regulatory phosphorylation site [posttranslational modification]; other site 713604012286 DNA binding site [nucleotide binding] 713604012287 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604012288 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604012289 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604012290 Ligand Binding Site [chemical binding]; other site 713604012291 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604012292 Ligand Binding Site [chemical binding]; other site 713604012293 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 713604012294 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 713604012295 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 713604012296 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 713604012297 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 713604012298 Type II/IV secretion system protein; Region: T2SE; pfam00437 713604012299 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 713604012300 Walker A motif; other site 713604012301 ATP binding site [chemical binding]; other site 713604012302 Walker B motif; other site 713604012303 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 713604012304 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604012305 Walker A motif; other site 713604012306 ATP binding site [chemical binding]; other site 713604012307 Walker B motif; other site 713604012308 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 713604012309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604012310 TIGR01777 family protein; Region: yfcH 713604012311 NAD(P) binding site [chemical binding]; other site 713604012312 active site 713604012313 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604012314 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604012315 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604012316 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 713604012317 NAD(P) binding site [chemical binding]; other site 713604012318 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 713604012319 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 713604012320 ligand binding site; other site 713604012321 oligomer interface; other site 713604012322 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 713604012323 dimer interface [polypeptide binding]; other site 713604012324 N-terminal domain interface [polypeptide binding]; other site 713604012325 sulfate 1 binding site; other site 713604012326 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 713604012327 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604012328 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604012329 Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; pfam02752 713604012330 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604012331 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604012332 anti sigma factor interaction site; other site 713604012333 regulatory phosphorylation site [posttranslational modification]; other site 713604012334 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 713604012335 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604012336 DNA binding residues [nucleotide binding] 713604012337 B12 binding domain; Region: B12-binding_2; pfam02607 713604012338 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 713604012339 putative hydrophobic ligand binding site [chemical binding]; other site 713604012340 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604012341 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604012342 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604012343 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604012344 sugar binding site [chemical binding]; other site 713604012345 TROVE domain; Region: TROVE; pfam05731 713604012346 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 713604012347 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604012348 elongation factor G; Reviewed; Region: PRK13351 713604012349 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604012350 G1 box; other site 713604012351 GTP/Mg2+ binding site [chemical binding]; other site 713604012352 G2 box; other site 713604012353 Switch I region; other site 713604012354 G3 box; other site 713604012355 Switch II region; other site 713604012356 G4 box; other site 713604012357 G5 box; other site 713604012358 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 713604012359 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 713604012360 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 713604012361 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604012362 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604012363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604012364 catalytic residue [active] 713604012365 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 713604012366 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 713604012367 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604012368 hydrophobic ligand binding site; other site 713604012369 hypothetical protein; Provisional; Region: PRK06185 713604012370 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604012371 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604012372 MarR family; Region: MarR; pfam01047 713604012373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012374 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604012375 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604012376 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 713604012377 active site 713604012378 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604012379 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604012380 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604012381 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 713604012382 acyl-CoA synthetase; Validated; Region: PRK05850 713604012383 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604012384 acyl-activating enzyme (AAE) consensus motif; other site 713604012385 active site 713604012386 Predicted esterase [General function prediction only]; Region: COG0627 713604012387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604012388 NAD(P) binding site [chemical binding]; other site 713604012389 active site 713604012390 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604012391 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604012392 active site 713604012393 TDP-binding site; other site 713604012394 acceptor substrate-binding pocket; other site 713604012395 homodimer interface [polypeptide binding]; other site 713604012396 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 713604012397 Uncharacterized conserved protein [Function unknown]; Region: COG1434 713604012398 putative active site [active] 713604012399 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 713604012400 ATP-NAD kinase; Region: NAD_kinase; pfam01513 713604012401 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 713604012402 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604012403 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604012404 short chain dehydrogenase; Provisional; Region: PRK05650 713604012405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604012406 NAD(P) binding site [chemical binding]; other site 713604012407 active site 713604012408 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604012409 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604012410 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604012411 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604012412 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604012413 Cytochrome P450; Region: p450; cl12078 713604012414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604012415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604012416 NB-ARC domain; Region: NB-ARC; pfam00931 713604012417 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 713604012418 regulatory protein interface [polypeptide binding]; other site 713604012419 active site 713604012420 regulatory phosphorylation site [posttranslational modification]; other site 713604012421 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 713604012422 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 713604012423 active site 713604012424 P-loop; other site 713604012425 phosphorylation site [posttranslational modification] 713604012426 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 713604012427 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 713604012428 active site 713604012429 phosphorylation site [posttranslational modification] 713604012430 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 713604012431 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 713604012432 putative substrate binding site [chemical binding]; other site 713604012433 putative ATP binding site [chemical binding]; other site 713604012434 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604012435 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604012436 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 713604012437 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 713604012438 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 713604012439 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 713604012440 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 713604012441 ATP binding site [chemical binding]; other site 713604012442 Asp23 family; Region: Asp23; pfam03780 713604012443 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 713604012444 active site 713604012445 catalytic triad [active] 713604012446 oxyanion hole [active] 713604012447 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 713604012448 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604012449 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604012450 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012451 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012452 DNA binding site [nucleotide binding] 713604012453 domain linker motif; other site 713604012454 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604012455 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604012456 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604012457 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 713604012458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012459 dimer interface [polypeptide binding]; other site 713604012460 conserved gate region; other site 713604012461 putative PBP binding loops; other site 713604012462 ABC-ATPase subunit interface; other site 713604012463 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604012464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012465 dimer interface [polypeptide binding]; other site 713604012466 conserved gate region; other site 713604012467 putative PBP binding loops; other site 713604012468 ABC-ATPase subunit interface; other site 713604012469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012471 DNA binding site [nucleotide binding] 713604012472 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 713604012473 putative ligand binding site [chemical binding]; other site 713604012474 putative dimerization interface [polypeptide binding]; other site 713604012475 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604012476 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 713604012477 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604012478 NodB motif; other site 713604012479 active site 713604012480 catalytic site [active] 713604012481 metal binding site [ion binding]; metal-binding site 713604012482 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604012483 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604012484 Di-iron ligands [ion binding]; other site 713604012485 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604012486 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604012487 DNA-binding site [nucleotide binding]; DNA binding site 713604012488 RNA-binding motif; other site 713604012489 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 713604012490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604012491 S-adenosylmethionine binding site [chemical binding]; other site 713604012492 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604012493 FAD binding domain; Region: FAD_binding_4; pfam01565 713604012494 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604012495 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 713604012496 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 713604012497 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 713604012498 oligomer interface [polypeptide binding]; other site 713604012499 metal binding site [ion binding]; metal-binding site 713604012500 metal binding site [ion binding]; metal-binding site 713604012501 putative Cl binding site [ion binding]; other site 713604012502 aspartate ring; other site 713604012503 basic sphincter; other site 713604012504 hydrophobic gate; other site 713604012505 periplasmic entrance; other site 713604012506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604012507 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 713604012508 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012509 dimerization interface [polypeptide binding]; other site 713604012510 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012511 dimerization interface [polypeptide binding]; other site 713604012512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012513 dimerization interface [polypeptide binding]; other site 713604012514 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 713604012515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012516 dimerization interface [polypeptide binding]; other site 713604012517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012518 dimerization interface [polypeptide binding]; other site 713604012519 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012520 dimerization interface [polypeptide binding]; other site 713604012521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604012522 dimerization interface [polypeptide binding]; other site 713604012523 GAF domain; Region: GAF_2; pfam13185 713604012524 GAF domain; Region: GAF; pfam01590 713604012525 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 713604012526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604012527 ATP binding site [chemical binding]; other site 713604012528 Mg2+ binding site [ion binding]; other site 713604012529 G-X-G motif; other site 713604012530 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 713604012531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604012532 active site 713604012533 phosphorylation site [posttranslational modification] 713604012534 intermolecular recognition site; other site 713604012535 dimerization interface [polypeptide binding]; other site 713604012536 ANTAR domain; Region: ANTAR; pfam03861 713604012537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604012538 PAS fold; Region: PAS_3; pfam08447 713604012539 putative active site [active] 713604012540 heme pocket [chemical binding]; other site 713604012541 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604012542 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 713604012543 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 713604012544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604012545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604012546 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 713604012547 putative dimerization interface [polypeptide binding]; other site 713604012548 pyruvate dehydrogenase; Provisional; Region: PRK06546 713604012549 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 713604012550 PYR/PP interface [polypeptide binding]; other site 713604012551 dimer interface [polypeptide binding]; other site 713604012552 tetramer interface [polypeptide binding]; other site 713604012553 TPP binding site [chemical binding]; other site 713604012554 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604012555 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 713604012556 TPP-binding site [chemical binding]; other site 713604012557 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 713604012558 Fructosamine kinase; Region: Fructosamin_kin; cl17579 713604012559 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 713604012560 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 713604012561 Zn binding site [ion binding]; other site 713604012562 Protein of unknown function, DUF488; Region: DUF488; cl01246 713604012563 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604012564 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604012565 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604012566 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012567 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012568 DNA binding site [nucleotide binding] 713604012569 domain linker motif; other site 713604012570 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604012571 dimerization interface [polypeptide binding]; other site 713604012572 ligand binding site [chemical binding]; other site 713604012573 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 713604012574 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604012575 Walker A/P-loop; other site 713604012576 ATP binding site [chemical binding]; other site 713604012577 Q-loop/lid; other site 713604012578 ABC transporter signature motif; other site 713604012579 Walker B; other site 713604012580 D-loop; other site 713604012581 H-loop/switch region; other site 713604012582 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 713604012583 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012584 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012585 TM-ABC transporter signature motif; other site 713604012586 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604012587 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604012588 TM-ABC transporter signature motif; other site 713604012589 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 713604012590 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 713604012591 ligand binding site [chemical binding]; other site 713604012592 Domain of unknown function (DUF718); Region: DUF718; pfam05336 713604012593 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 713604012594 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 713604012595 short chain dehydrogenase; Validated; Region: PRK08324 713604012596 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 713604012597 active site 713604012598 Zn2+ binding site [ion binding]; other site 713604012599 intersubunit interface [polypeptide binding]; other site 713604012600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604012601 NAD(P) binding site [chemical binding]; other site 713604012602 active site 713604012603 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 713604012604 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 713604012605 hexamer (dimer of trimers) interface [polypeptide binding]; other site 713604012606 substrate binding site [chemical binding]; other site 713604012607 trimer interface [polypeptide binding]; other site 713604012608 Mn binding site [ion binding]; other site 713604012609 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 713604012610 N- and C-terminal domain interface [polypeptide binding]; other site 713604012611 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 713604012612 active site 713604012613 putative catalytic site [active] 713604012614 metal binding site [ion binding]; metal-binding site 713604012615 ATP binding site [chemical binding]; other site 713604012616 carbohydrate binding site [chemical binding]; other site 713604012617 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604012618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604012619 active site 713604012620 phosphorylation site [posttranslational modification] 713604012621 intermolecular recognition site; other site 713604012622 dimerization interface [polypeptide binding]; other site 713604012623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604012624 DNA binding residues [nucleotide binding] 713604012625 dimerization interface [polypeptide binding]; other site 713604012626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604012627 Histidine kinase; Region: HisKA_3; pfam07730 713604012628 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012629 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012630 DNA binding site [nucleotide binding] 713604012631 domain linker motif; other site 713604012632 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 713604012633 putative dimerization interface [polypeptide binding]; other site 713604012634 putative ligand binding site [chemical binding]; other site 713604012635 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604012636 putative metal binding site [ion binding]; other site 713604012637 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604012638 putative metal binding site [ion binding]; other site 713604012639 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 713604012640 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 713604012641 active site 713604012642 catalytic site [active] 713604012643 Domain of unknown function (DUF305); Region: DUF305; cl17794 713604012644 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604012645 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604012646 sugar binding site [chemical binding]; other site 713604012647 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 713604012648 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604012649 active site 713604012650 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604012651 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 713604012652 DNA polymerase IV; Validated; Region: PRK03858 713604012653 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 713604012654 active site 713604012655 DNA binding site [nucleotide binding] 713604012656 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604012657 Leucine carboxyl methyltransferase; Region: LCM; cl01306 713604012658 Lsr2; Region: Lsr2; pfam11774 713604012659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604012660 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 713604012661 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604012662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604012663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604012664 dimerization interface [polypeptide binding]; other site 713604012665 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 713604012666 CoA binding domain; Region: CoA_binding; pfam02629 713604012667 CoA-ligase; Region: Ligase_CoA; pfam00549 713604012668 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 713604012669 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 713604012670 CoA-ligase; Region: Ligase_CoA; pfam00549 713604012671 hypothetical protein; Provisional; Region: PRK05858 713604012672 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604012673 PYR/PP interface [polypeptide binding]; other site 713604012674 dimer interface [polypeptide binding]; other site 713604012675 TPP binding site [chemical binding]; other site 713604012676 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604012677 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 713604012678 TPP-binding site; other site 713604012679 dimer interface [polypeptide binding]; other site 713604012680 formyl-coenzyme A transferase; Provisional; Region: PRK05398 713604012681 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604012682 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 713604012683 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 713604012684 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 713604012685 CoA binding domain; Region: CoA_binding_2; pfam13380 713604012686 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 713604012687 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 713604012688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012689 putative substrate translocation pore; other site 713604012690 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604012691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604012692 DNA-binding site [nucleotide binding]; DNA binding site 713604012693 FCD domain; Region: FCD; pfam07729 713604012694 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 713604012695 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 713604012696 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 713604012697 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 713604012698 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604012699 molybdopterin cofactor binding site; other site 713604012700 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 713604012701 molybdopterin cofactor binding site; other site 713604012702 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 713604012703 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 713604012704 putative dimer interface [polypeptide binding]; other site 713604012705 [2Fe-2S] cluster binding site [ion binding]; other site 713604012706 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 713604012707 SLBB domain; Region: SLBB; pfam10531 713604012708 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 713604012709 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604012710 catalytic loop [active] 713604012711 iron binding site [ion binding]; other site 713604012712 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 713604012713 4Fe-4S binding domain; Region: Fer4; pfam00037 713604012714 Molybdopterin oxidoreductase Fe4S4 domain; Region: Molybdop_Fe4S4; pfam04879 713604012715 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 713604012716 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604012717 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 713604012718 glyoxylate carboligase; Provisional; Region: PRK11269 713604012719 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604012720 PYR/PP interface [polypeptide binding]; other site 713604012721 dimer interface [polypeptide binding]; other site 713604012722 TPP binding site [chemical binding]; other site 713604012723 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604012724 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604012725 TPP-binding site [chemical binding]; other site 713604012726 4-hydroxybenzoyl-CoA reductase, beta subunit; Region: 4hydrxCoA_B; TIGR03195 713604012727 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 713604012728 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604012729 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 713604012730 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604012731 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 713604012732 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604012733 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604012734 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 713604012735 nucleoside/Zn binding site; other site 713604012736 dimer interface [polypeptide binding]; other site 713604012737 catalytic motif [active] 713604012738 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 713604012739 Sulfate transporter family; Region: Sulfate_transp; pfam00916 713604012740 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 713604012741 putative active site pocket [active] 713604012742 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 713604012743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604012744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604012745 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 713604012746 Domain interface; other site 713604012747 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 713604012748 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604012749 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 713604012750 SPFH domain / Band 7 family; Region: Band_7; pfam01145 713604012751 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 713604012752 nudix motif; other site 713604012753 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 713604012754 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604012755 hypothetical protein; Provisional; Region: PRK07588 713604012756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604012757 putative DNA binding site [nucleotide binding]; other site 713604012758 putative Zn2+ binding site [ion binding]; other site 713604012759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 713604012760 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 713604012761 DNA-binding interface [nucleotide binding]; DNA binding site 713604012762 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604012763 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 713604012764 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604012765 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 713604012766 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012767 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012768 DNA binding site [nucleotide binding] 713604012769 domain linker motif; other site 713604012770 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604012771 dimerization interface [polypeptide binding]; other site 713604012772 ligand binding site [chemical binding]; other site 713604012773 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 713604012774 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 713604012775 glutaminase; Provisional; Region: PRK00971 713604012776 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 713604012777 AAA domain; Region: AAA_12; pfam13087 713604012778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 713604012779 YheO-like PAS domain; Region: PAS_6; pfam08348 713604012780 HTH domain; Region: HTH_22; pfam13309 713604012781 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 713604012782 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 713604012783 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604012784 catalytic residue [active] 713604012785 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604012786 phosphate binding site [ion binding]; other site 713604012787 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 713604012788 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604012789 phosphate binding site [ion binding]; other site 713604012790 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604012791 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 713604012792 active site 713604012793 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 713604012794 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604012795 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 713604012796 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 713604012797 putative NADP binding site [chemical binding]; other site 713604012798 active site 713604012799 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 713604012800 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604012801 active site 713604012802 Acyl transferase domain; Region: Acyl_transf_1; cl08282 713604012803 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 713604012804 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 713604012805 Phosphopantetheine attachment site; Region: PP-binding; cl09936 713604012806 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604012807 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604012808 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 713604012809 catalytic site [active] 713604012810 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604012811 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604012812 classical (c) SDRs; Region: SDR_c; cd05233 713604012813 NAD(P) binding site [chemical binding]; other site 713604012814 active site 713604012815 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604012816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012817 putative substrate translocation pore; other site 713604012818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012819 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 713604012820 histidinol-phosphatase; Provisional; Region: PRK05588 713604012821 active site 713604012822 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 713604012823 nucleotide binding site [chemical binding]; other site 713604012824 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 713604012825 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604012826 dimer interface [polypeptide binding]; other site 713604012827 active site 713604012828 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604012829 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604012830 dimerization interface [polypeptide binding]; other site 713604012831 putative DNA binding site [nucleotide binding]; other site 713604012832 putative Zn2+ binding site [ion binding]; other site 713604012833 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 713604012834 sugar binding site [chemical binding]; other site 713604012835 CARDB; Region: CARDB; pfam07705 713604012836 CARDB; Region: CARDB; pfam07705 713604012837 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604012838 putative metal binding site [ion binding]; other site 713604012839 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 713604012840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604012841 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604012842 NAD(P) binding site [chemical binding]; other site 713604012843 active site 713604012844 ATP phosphoribosyltransferase; Region: HisG; cl15266 713604012845 DoxX-like family; Region: DoxX_2; pfam13564 713604012846 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604012847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604012848 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604012849 dimerization interface [polypeptide binding]; other site 713604012850 substrate binding pocket [chemical binding]; other site 713604012851 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 713604012852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604012853 motif II; other site 713604012854 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604012855 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604012856 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604012857 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604012858 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604012859 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604012860 DNA binding site [nucleotide binding] 713604012861 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604012862 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 713604012863 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 713604012864 hypothetical protein; Provisional; Region: PRK07906 713604012865 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 713604012866 putative metal binding site [ion binding]; other site 713604012867 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604012868 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604012869 hypothetical protein; Provisional; Region: PRK08317 713604012870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604012871 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604012872 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604012873 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604012874 putative DNA binding site [nucleotide binding]; other site 713604012875 putative Zn2+ binding site [ion binding]; other site 713604012876 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604012877 hydrophobic ligand binding site; other site 713604012878 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604012879 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604012880 active site 713604012881 catalytic tetrad [active] 713604012882 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604012883 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 713604012884 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 713604012885 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604012886 catalytic core [active] 713604012887 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 713604012888 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 713604012889 active site 713604012890 Zn binding site [ion binding]; other site 713604012891 Clp protease; Region: CLP_protease; pfam00574 713604012892 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 713604012893 oligomer interface [polypeptide binding]; other site 713604012894 active site residues [active] 713604012895 malate dehydrogenase; Provisional; Region: PRK05442 713604012896 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 713604012897 NAD(P) binding site [chemical binding]; other site 713604012898 dimer interface [polypeptide binding]; other site 713604012899 malate binding site [chemical binding]; other site 713604012900 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604012901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604012902 putative DNA binding site [nucleotide binding]; other site 713604012903 putative Zn2+ binding site [ion binding]; other site 713604012904 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604012905 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604012906 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 713604012907 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 713604012908 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604012909 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604012910 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604012911 sugar binding site [chemical binding]; other site 713604012912 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604012913 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604012914 Tannase and feruloyl esterase; Region: Tannase; pfam07519 713604012915 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604012916 Cupin domain; Region: Cupin_2; cl17218 713604012917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604012918 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604012919 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604012920 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604012921 NAD(P) binding site [chemical binding]; other site 713604012922 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 713604012923 hypothetical protein; Provisional; Region: PRK07906 713604012924 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 713604012925 putative metal binding site [ion binding]; other site 713604012926 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 713604012927 SxDxEG motif; other site 713604012928 active site 713604012929 metal binding site [ion binding]; metal-binding site 713604012930 homopentamer interface [polypeptide binding]; other site 713604012931 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 713604012932 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 713604012933 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604012934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012935 putative PBP binding loops; other site 713604012936 dimer interface [polypeptide binding]; other site 713604012937 ABC-ATPase subunit interface; other site 713604012938 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604012939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604012940 dimer interface [polypeptide binding]; other site 713604012941 conserved gate region; other site 713604012942 putative PBP binding loops; other site 713604012943 ABC-ATPase subunit interface; other site 713604012944 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 713604012945 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604012946 Walker A/P-loop; other site 713604012947 ATP binding site [chemical binding]; other site 713604012948 Q-loop/lid; other site 713604012949 ABC transporter signature motif; other site 713604012950 Walker B; other site 713604012951 D-loop; other site 713604012952 H-loop/switch region; other site 713604012953 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604012954 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604012955 Walker A/P-loop; other site 713604012956 ATP binding site [chemical binding]; other site 713604012957 Q-loop/lid; other site 713604012958 ABC transporter signature motif; other site 713604012959 Walker B; other site 713604012960 D-loop; other site 713604012961 H-loop/switch region; other site 713604012962 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604012963 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 713604012964 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 713604012965 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 713604012966 dimer interface [polypeptide binding]; other site 713604012967 catalytic triad [active] 713604012968 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 713604012969 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604012970 conserved hypothetical protein; Region: TIGR03847 713604012971 conserved hypothetical protein; Region: TIGR03843 713604012972 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 713604012973 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 713604012974 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 713604012975 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 713604012976 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 713604012977 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 713604012978 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 713604012979 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604012980 active site 713604012981 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 713604012982 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 713604012983 Mechanosensitive ion channel; Region: MS_channel; pfam00924 713604012984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604012985 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604012986 putative substrate translocation pore; other site 713604012987 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604012988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604012989 hypothetical protein; Provisional; Region: PRK06834 713604012990 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604012991 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604012992 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604012993 active site 713604012994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604012995 dimerization interface [polypeptide binding]; other site 713604012996 putative DNA binding site [nucleotide binding]; other site 713604012997 putative Zn2+ binding site [ion binding]; other site 713604012998 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 713604012999 putative hydrophobic ligand binding site [chemical binding]; other site 713604013000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013002 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 713604013003 active site 713604013004 catalytic triad [active] 713604013005 oxyanion hole [active] 713604013006 RibD C-terminal domain; Region: RibD_C; cl17279 713604013007 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604013008 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 713604013009 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604013010 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604013011 active site 713604013012 DNA binding site [nucleotide binding] 713604013013 Int/Topo IB signature motif; other site 713604013014 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604013015 YCII-related domain; Region: YCII; cl00999 713604013016 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604013017 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604013018 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013019 dimerization interface [polypeptide binding]; other site 713604013020 putative DNA binding site [nucleotide binding]; other site 713604013021 putative Zn2+ binding site [ion binding]; other site 713604013022 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 713604013023 putative hydrophobic ligand binding site [chemical binding]; other site 713604013024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013025 Cupin; Region: Cupin_6; pfam12852 713604013026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604013027 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604013028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604013029 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604013030 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604013031 NAD(P) binding site [chemical binding]; other site 713604013032 active site 713604013033 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 713604013034 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 713604013035 YCII-related domain; Region: YCII; cl00999 713604013036 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604013037 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604013038 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604013039 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604013040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013042 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604013043 Cytochrome P450; Region: p450; cl12078 713604013044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013046 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604013047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013048 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604013049 Walker A/P-loop; other site 713604013050 ATP binding site [chemical binding]; other site 713604013051 Q-loop/lid; other site 713604013052 ABC transporter signature motif; other site 713604013053 Walker B; other site 713604013054 D-loop; other site 713604013055 H-loop/switch region; other site 713604013056 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604013057 SNF2 Helicase protein; Region: DUF3670; pfam12419 713604013058 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 713604013059 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604013060 ATP binding site [chemical binding]; other site 713604013061 putative Mg++ binding site [ion binding]; other site 713604013062 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 713604013063 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604013064 nucleotide binding region [chemical binding]; other site 713604013065 ATP-binding site [chemical binding]; other site 713604013066 Uncharacterized conserved protein [Function unknown]; Region: COG4279 713604013067 SWIM zinc finger; Region: SWIM; pfam04434 713604013068 hypothetical protein; Provisional; Region: PRK07236 713604013069 hypothetical protein; Validated; Region: PRK05868 713604013070 hypothetical protein; Provisional; Region: PRK07236 713604013071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013073 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604013074 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 713604013075 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604013076 active site 713604013077 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 713604013078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604013080 salt bridge; other site 713604013081 non-specific DNA binding site [nucleotide binding]; other site 713604013082 sequence-specific DNA binding site [nucleotide binding]; other site 713604013083 Cupin domain; Region: Cupin_2; cl17218 713604013084 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 713604013085 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604013086 hydrophobic ligand binding site; other site 713604013087 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013088 dimerization interface [polypeptide binding]; other site 713604013089 putative DNA binding site [nucleotide binding]; other site 713604013090 putative Zn2+ binding site [ion binding]; other site 713604013091 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 713604013092 putative hydrophobic ligand binding site [chemical binding]; other site 713604013093 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604013094 active site 713604013095 DNA binding site [nucleotide binding] 713604013096 Int/Topo IB signature motif; other site 713604013097 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 713604013098 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 713604013099 putative active site [active] 713604013100 catalytic site [active] 713604013101 putative metal binding site [ion binding]; other site 713604013102 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 713604013103 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604013104 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 713604013105 thymidine kinase; Provisional; Region: PRK04296 713604013106 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604013107 ATP binding site [chemical binding]; other site 713604013108 Walker A motif; other site 713604013109 Walker B motif; other site 713604013110 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 713604013111 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 713604013112 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 713604013113 dimer interface [polypeptide binding]; other site 713604013114 ADP-ribose binding site [chemical binding]; other site 713604013115 active site 713604013116 nudix motif; other site 713604013117 metal binding site [ion binding]; metal-binding site 713604013118 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 713604013119 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604013120 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604013121 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 713604013122 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 713604013123 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 713604013124 Ligand binding site; other site 713604013125 Putative Catalytic site; other site 713604013126 DXD motif; other site 713604013127 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 713604013128 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 713604013129 putative active site [active] 713604013130 catalytic triad [active] 713604013131 putative dimer interface [polypeptide binding]; other site 713604013132 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 713604013133 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604013134 active site 713604013135 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 713604013136 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 713604013137 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604013138 conserved cys residue [active] 713604013139 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604013140 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604013141 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604013142 DNA binding site [nucleotide binding] 713604013143 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604013144 AAA ATPase domain; Region: AAA_16; pfam13191 713604013145 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604013146 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604013147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604013148 TPR motif; other site 713604013149 binding surface 713604013150 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604013151 Homeodomain-like domain; Region: HTH_23; pfam13384 713604013152 Winged helix-turn helix; Region: HTH_29; pfam13551 713604013153 Homeodomain-like domain; Region: HTH_32; pfam13565 713604013154 DDE superfamily endonuclease; Region: DDE_3; pfam13358 713604013155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 713604013156 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 713604013157 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 713604013158 active site 713604013159 zinc binding site [ion binding]; other site 713604013160 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604013161 DNA binding site [nucleotide binding] 713604013162 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604013163 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 713604013164 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 713604013165 active site 713604013166 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604013167 active site 713604013168 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 713604013169 B12 binding site [chemical binding]; other site 713604013170 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 713604013171 substrate binding site [chemical binding]; other site 713604013172 B12 cofactor binding site [chemical binding]; other site 713604013173 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 713604013174 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 713604013175 asparagine synthetase A; Reviewed; Region: PRK06462 713604013176 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604013177 motif 1; other site 713604013178 dimer interface [polypeptide binding]; other site 713604013179 active site 713604013180 motif 2; other site 713604013181 motif 3; other site 713604013182 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604013183 phosphate binding site [ion binding]; other site 713604013184 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 713604013185 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013186 acyl-activating enzyme (AAE) consensus motif; other site 713604013187 AMP binding site [chemical binding]; other site 713604013188 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 713604013189 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 713604013190 homodimer interface [polypeptide binding]; other site 713604013191 substrate-cofactor binding pocket; other site 713604013192 catalytic residue [active] 713604013193 FkbH-like domain; Region: FkbH; TIGR01686 713604013194 Acid Phosphatase; Region: Acid_PPase; cl17256 713604013195 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604013196 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604013197 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604013198 active site 713604013199 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604013200 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 713604013201 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604013202 catalytic residue [active] 713604013203 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 713604013204 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 713604013205 active sites [active] 713604013206 tetramer interface [polypeptide binding]; other site 713604013207 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 713604013208 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604013209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604013210 dimer interface [polypeptide binding]; other site 713604013211 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604013212 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 713604013213 acyl carrier protein; Provisional; Region: PRK07081 713604013214 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 713604013215 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604013216 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604013217 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604013218 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604013219 Condensation domain; Region: Condensation; pfam00668 713604013220 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013221 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013222 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013223 acyl-activating enzyme (AAE) consensus motif; other site 713604013224 AMP binding site [chemical binding]; other site 713604013225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013226 Condensation domain; Region: Condensation; pfam00668 713604013227 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604013228 Condensation domain; Region: Condensation; pfam00668 713604013229 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013230 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013231 acyl-activating enzyme (AAE) consensus motif; other site 713604013232 AMP binding site [chemical binding]; other site 713604013233 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013234 Condensation domain; Region: Condensation; pfam00668 713604013235 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013236 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013237 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013238 acyl-activating enzyme (AAE) consensus motif; other site 713604013239 AMP binding site [chemical binding]; other site 713604013240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013241 Condensation domain; Region: Condensation; pfam00668 713604013242 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013243 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013244 Condensation domain; Region: Condensation; pfam00668 713604013245 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604013246 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604013247 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604013248 MbtH-like protein; Region: MbtH; cl01279 713604013249 Condensation domain; Region: Condensation; pfam00668 713604013250 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013251 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013252 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013253 Condensation domain; Region: Condensation; pfam00668 713604013254 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013255 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013256 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013257 acyl-activating enzyme (AAE) consensus motif; other site 713604013258 AMP binding site [chemical binding]; other site 713604013259 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013260 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013261 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013262 acyl-activating enzyme (AAE) consensus motif; other site 713604013263 AMP binding site [chemical binding]; other site 713604013264 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013265 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 713604013266 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 713604013267 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604013268 allantoate amidohydrolase; Reviewed; Region: PRK09290 713604013269 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 713604013270 active site 713604013271 metal binding site [ion binding]; metal-binding site 713604013272 dimer interface [polypeptide binding]; other site 713604013273 Helix-turn-helix domain; Region: HTH_20; pfam12840 713604013274 Methyltransferase domain; Region: Methyltransf_18; pfam12847 713604013275 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604013276 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604013277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604013278 homodimer interface [polypeptide binding]; other site 713604013279 catalytic residue [active] 713604013280 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604013281 Predicted ATPase [General function prediction only]; Region: COG3903 713604013282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604013283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604013284 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 713604013285 putative substrate binding pocket [chemical binding]; other site 713604013286 putative dimerization interface [polypeptide binding]; other site 713604013287 FAD binding domain; Region: FAD_binding_3; pfam01494 713604013288 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604013289 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 713604013290 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604013291 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604013292 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604013293 NIPSNAP; Region: NIPSNAP; pfam07978 713604013294 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 713604013295 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 713604013296 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604013297 active site pocket [active] 713604013298 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604013299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604013300 DNA-binding site [nucleotide binding]; DNA binding site 713604013301 FCD domain; Region: FCD; pfam07729 713604013302 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604013303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604013304 dimer interface [polypeptide binding]; other site 713604013305 conserved gate region; other site 713604013306 ABC-ATPase subunit interface; other site 713604013307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604013308 dimer interface [polypeptide binding]; other site 713604013309 conserved gate region; other site 713604013310 putative PBP binding loops; other site 713604013311 ABC-ATPase subunit interface; other site 713604013312 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604013313 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604013314 MbtH-like protein; Region: MbtH; cl01279 713604013315 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013316 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013317 acyl-activating enzyme (AAE) consensus motif; other site 713604013318 AMP binding site [chemical binding]; other site 713604013319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013320 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 713604013321 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604013322 dimer interface [polypeptide binding]; other site 713604013323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604013324 catalytic residue [active] 713604013325 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 713604013326 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 713604013327 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 713604013328 B12 binding site [chemical binding]; other site 713604013329 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 713604013330 substrate binding site [chemical binding]; other site 713604013331 B12 cofactor binding site [chemical binding]; other site 713604013332 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 713604013333 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 713604013334 aspartate racemase; Region: asp_race; TIGR00035 713604013335 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 713604013336 Condensation domain; Region: Condensation; pfam00668 713604013337 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013338 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013339 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013340 acyl-activating enzyme (AAE) consensus motif; other site 713604013341 AMP binding site [chemical binding]; other site 713604013342 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013343 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 713604013344 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013345 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013346 acyl-activating enzyme (AAE) consensus motif; other site 713604013347 AMP binding site [chemical binding]; other site 713604013348 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013349 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 713604013350 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 713604013351 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604013352 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 713604013353 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013354 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013355 acyl-activating enzyme (AAE) consensus motif; other site 713604013356 AMP binding site [chemical binding]; other site 713604013357 Condensation domain; Region: Condensation; pfam00668 713604013358 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604013359 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013360 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013361 acyl-activating enzyme (AAE) consensus motif; other site 713604013362 AMP binding site [chemical binding]; other site 713604013363 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604013364 Condensation domain; Region: Condensation; pfam00668 713604013365 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 713604013366 Condensation domain; Region: Condensation; pfam00668 713604013367 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604013368 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604013369 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604013370 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604013371 DNA binding site [nucleotide binding] 713604013372 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604013373 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604013374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604013375 TPR motif; other site 713604013376 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604013377 binding surface 713604013378 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 713604013379 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604013380 DNA binding residues [nucleotide binding] 713604013381 putative dimer interface [polypeptide binding]; other site 713604013382 HEAT repeats; Region: HEAT_2; pfam13646 713604013383 Leishmanolysin; Region: Peptidase_M8; pfam01457 713604013384 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604013385 Switch II region; other site 713604013386 G4 box; other site 713604013387 G5 box; other site 713604013388 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 713604013389 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604013390 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604013391 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604013392 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 713604013393 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604013394 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604013395 putative sugar binding sites [chemical binding]; other site 713604013396 Q-X-W motif; other site 713604013397 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 713604013398 active site 713604013399 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604013400 Cytochrome P450; Region: p450; pfam00067 713604013401 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604013402 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604013403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604013404 S-adenosylmethionine binding site [chemical binding]; other site 713604013405 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604013406 MarR family; Region: MarR_2; pfam12802 713604013407 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604013408 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604013409 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 713604013410 Uncharacterized conserved protein [Function unknown]; Region: COG1359 713604013411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604013412 Histidine kinase; Region: HisKA_3; pfam07730 713604013413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604013414 ATP binding site [chemical binding]; other site 713604013415 Mg2+ binding site [ion binding]; other site 713604013416 G-X-G motif; other site 713604013417 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604013418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604013419 active site 713604013420 phosphorylation site [posttranslational modification] 713604013421 intermolecular recognition site; other site 713604013422 dimerization interface [polypeptide binding]; other site 713604013423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604013424 DNA binding residues [nucleotide binding] 713604013425 dimerization interface [polypeptide binding]; other site 713604013426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604013427 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604013428 DNA binding residues [nucleotide binding] 713604013429 dimerization interface [polypeptide binding]; other site 713604013430 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 713604013431 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 713604013432 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 713604013433 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 713604013434 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 713604013435 metal ion-dependent adhesion site (MIDAS); other site 713604013436 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 713604013437 phage tail protein domain; Region: tail_TIGR02242 713604013438 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 713604013439 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 713604013440 PAAR motif; Region: PAAR_motif; pfam05488 713604013441 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 713604013442 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 713604013443 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 713604013444 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 713604013445 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 713604013446 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 713604013447 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 713604013448 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 713604013449 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 713604013450 Phage-related protein [Function unknown]; Region: COG5412 713604013451 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 713604013452 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604013453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604013454 ATP binding site [chemical binding]; other site 713604013455 Walker A motif; other site 713604013456 Walker B motif; other site 713604013457 arginine finger; other site 713604013458 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 713604013459 Right handed beta helix region; Region: Beta_helix; pfam13229 713604013460 hypothetical protein; Provisional; Region: PRK08204 713604013461 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604013462 active site 713604013463 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 713604013464 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604013465 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604013466 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604013467 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604013468 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 713604013469 active site 713604013470 citrylCoA binding site [chemical binding]; other site 713604013471 oxalacetate binding site [chemical binding]; other site 713604013472 coenzyme A binding site [chemical binding]; other site 713604013473 catalytic triad [active] 713604013474 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 713604013475 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 713604013476 active site 713604013477 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604013478 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604013479 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604013480 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 713604013481 active site 713604013482 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 713604013483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013484 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 713604013485 Walker A/P-loop; other site 713604013486 ATP binding site [chemical binding]; other site 713604013487 Q-loop/lid; other site 713604013488 ABC transporter signature motif; other site 713604013489 Walker B; other site 713604013490 D-loop; other site 713604013491 H-loop/switch region; other site 713604013492 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604013493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013494 Walker A/P-loop; other site 713604013495 ATP binding site [chemical binding]; other site 713604013496 Q-loop/lid; other site 713604013497 ABC transporter signature motif; other site 713604013498 Walker B; other site 713604013499 D-loop; other site 713604013500 H-loop/switch region; other site 713604013501 hypothetical protein; Validated; Region: PRK05868 713604013502 hypothetical protein; Provisional; Region: PRK07236 713604013503 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604013504 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604013505 short chain dehydrogenase; Provisional; Region: PRK06180 713604013506 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604013507 NADP binding site [chemical binding]; other site 713604013508 active site 713604013509 steroid binding site; other site 713604013510 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604013511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604013512 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604013513 dimerization interface [polypeptide binding]; other site 713604013514 substrate binding pocket [chemical binding]; other site 713604013515 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 713604013516 active site residue [active] 713604013517 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 713604013518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013519 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604013520 active site 713604013521 catalytic triad [active] 713604013522 oxyanion hole [active] 713604013523 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013524 putative DNA binding site [nucleotide binding]; other site 713604013525 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604013526 putative Zn2+ binding site [ion binding]; other site 713604013527 AsnC family; Region: AsnC_trans_reg; pfam01037 713604013528 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 713604013529 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 713604013530 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 713604013531 active site 713604013532 5'-3' exonuclease (including N-terminal domain of PolI) [DNA replication, recombination, and repair]; Region: Exo; COG0258 713604013533 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 713604013534 active site 713604013535 metal binding site 1 [ion binding]; metal-binding site 713604013536 putative 5' ssDNA interaction site; other site 713604013537 metal binding site 3; metal-binding site 713604013538 metal binding site 2 [ion binding]; metal-binding site 713604013539 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 713604013540 putative DNA binding site [nucleotide binding]; other site 713604013541 putative metal binding site [ion binding]; other site 713604013542 hypothetical protein; Provisional; Region: PRK01346 713604013543 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 713604013544 hypothetical protein; Provisional; Region: PRK01346 713604013545 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 713604013546 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 713604013547 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 713604013548 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604013549 ATP binding site [chemical binding]; other site 713604013550 putative Mg++ binding site [ion binding]; other site 713604013551 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604013552 nucleotide binding region [chemical binding]; other site 713604013553 ATP-binding site [chemical binding]; other site 713604013554 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 713604013555 diacylglycerol kinase; Reviewed; Region: PRK11914 713604013556 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 713604013557 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 713604013558 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 713604013559 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 713604013560 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604013561 WYL domain; Region: WYL; pfam13280 713604013562 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604013563 WYL domain; Region: WYL; pfam13280 713604013564 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604013565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013566 dimerization interface [polypeptide binding]; other site 713604013567 putative DNA binding site [nucleotide binding]; other site 713604013568 putative Zn2+ binding site [ion binding]; other site 713604013569 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604013570 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604013571 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604013572 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 713604013573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604013574 NAD(P) binding site [chemical binding]; other site 713604013575 active site 713604013576 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 713604013577 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 713604013578 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 713604013579 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 713604013580 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 713604013581 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 713604013582 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604013583 active site 713604013584 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 713604013585 active site 713604013586 Pup-like protein; Region: Pup; pfam05639 713604013587 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 713604013588 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 713604013589 nudix motif; other site 713604013590 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 713604013591 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604013592 active site 713604013593 catalytic tetrad [active] 713604013594 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013595 dimerization interface [polypeptide binding]; other site 713604013596 putative DNA binding site [nucleotide binding]; other site 713604013597 putative Zn2+ binding site [ion binding]; other site 713604013598 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604013599 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 713604013600 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 713604013601 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 713604013602 EamA-like transporter family; Region: EamA; pfam00892 713604013603 proteasome ATPase; Region: pup_AAA; TIGR03689 713604013604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604013605 Walker A motif; other site 713604013606 ATP binding site [chemical binding]; other site 713604013607 Walker B motif; other site 713604013608 arginine finger; other site 713604013609 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 713604013610 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 713604013611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604013612 S-adenosylmethionine binding site [chemical binding]; other site 713604013613 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 713604013614 active site 713604013615 putative substrate binding region [chemical binding]; other site 713604013616 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 713604013617 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 713604013618 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 713604013619 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604013620 P-loop; other site 713604013621 Magnesium ion binding site [ion binding]; other site 713604013622 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604013623 Magnesium ion binding site [ion binding]; other site 713604013624 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 713604013625 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 713604013626 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 713604013627 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 713604013628 homodimer interface [polypeptide binding]; other site 713604013629 putative metal binding site [ion binding]; other site 713604013630 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 713604013631 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 713604013632 DNA binding site [nucleotide binding] 713604013633 active site 713604013634 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 713604013635 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 713604013636 AlkA N-terminal domain; Region: AlkA_N; pfam06029 713604013637 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 713604013638 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 713604013639 minor groove reading motif; other site 713604013640 helix-hairpin-helix signature motif; other site 713604013641 substrate binding pocket [chemical binding]; other site 713604013642 active site 713604013643 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 713604013644 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 713604013645 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604013646 motif II; other site 713604013647 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 713604013648 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 713604013649 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 713604013650 substrate binding pocket [chemical binding]; other site 713604013651 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 713604013652 B12 binding site [chemical binding]; other site 713604013653 cobalt ligand [ion binding]; other site 713604013654 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 713604013655 PAC2 family; Region: PAC2; pfam09754 713604013656 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604013657 active site 713604013658 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604013659 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604013660 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604013661 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604013662 active site 713604013663 metal binding site [ion binding]; metal-binding site 713604013664 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604013665 alkylmercury lyase; Provisional; Region: PRK13239 713604013666 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604013667 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604013668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 713604013669 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604013670 dimerization interface [polypeptide binding]; other site 713604013671 putative DNA binding site [nucleotide binding]; other site 713604013672 putative Zn2+ binding site [ion binding]; other site 713604013673 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604013674 MarR family; Region: MarR_2; cl17246 713604013675 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 713604013676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013677 Walker A/P-loop; other site 713604013678 ATP binding site [chemical binding]; other site 713604013679 Q-loop/lid; other site 713604013680 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604013681 ABC transporter signature motif; other site 713604013682 Walker B; other site 713604013683 D-loop; other site 713604013684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013685 Walker A/P-loop; other site 713604013686 ATP binding site [chemical binding]; other site 713604013687 Q-loop/lid; other site 713604013688 ABC transporter signature motif; other site 713604013689 Walker B; other site 713604013690 D-loop; other site 713604013691 H-loop/switch region; other site 713604013692 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604013693 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 713604013694 active site 713604013695 HIGH motif; other site 713604013696 nucleotide binding site [chemical binding]; other site 713604013697 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604013698 active site 713604013699 KMSKS motif; other site 713604013700 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 713604013701 putative tRNA binding surface [nucleotide binding]; other site 713604013702 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604013703 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 713604013704 DNA binding residues [nucleotide binding] 713604013705 dimer interface [polypeptide binding]; other site 713604013706 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 713604013707 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604013708 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604013709 active site 713604013710 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 713604013711 Protein of unknown function, DUF484; Region: DUF484; cl17449 713604013712 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 713604013713 metal ion-dependent adhesion site (MIDAS); other site 713604013714 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 713604013715 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 713604013716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604013717 ferrochelatase; Reviewed; Region: hemH; PRK00035 713604013718 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 713604013719 C-terminal domain interface [polypeptide binding]; other site 713604013720 active site 713604013721 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 713604013722 active site 713604013723 N-terminal domain interface [polypeptide binding]; other site 713604013724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013726 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604013727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604013728 putative substrate translocation pore; other site 713604013729 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 713604013730 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 713604013731 NAD binding site [chemical binding]; other site 713604013732 homotetramer interface [polypeptide binding]; other site 713604013733 homodimer interface [polypeptide binding]; other site 713604013734 substrate binding site [chemical binding]; other site 713604013735 active site 713604013736 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 713604013737 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 713604013738 NAD(P) binding site [chemical binding]; other site 713604013739 homotetramer interface [polypeptide binding]; other site 713604013740 homodimer interface [polypeptide binding]; other site 713604013741 active site 713604013742 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 713604013743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604013744 putative substrate translocation pore; other site 713604013745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604013746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604013747 active site 713604013748 phosphorylation site [posttranslational modification] 713604013749 intermolecular recognition site; other site 713604013750 dimerization interface [polypeptide binding]; other site 713604013751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604013752 DNA binding site [nucleotide binding] 713604013753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604013754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604013755 dimerization interface [polypeptide binding]; other site 713604013756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604013757 dimer interface [polypeptide binding]; other site 713604013758 phosphorylation site [posttranslational modification] 713604013759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604013760 ATP binding site [chemical binding]; other site 713604013761 Mg2+ binding site [ion binding]; other site 713604013762 G-X-G motif; other site 713604013763 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 713604013764 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 713604013765 active site 713604013766 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 713604013767 hypothetical protein; Provisional; Region: PRK13685 713604013768 von Willebrand factor type A domain; Region: VWA_2; pfam13519 713604013769 metal ion-dependent adhesion site (MIDAS); other site 713604013770 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 713604013771 Protein of unknown function DUF58; Region: DUF58; pfam01882 713604013772 MoxR-like ATPases [General function prediction only]; Region: COG0714 713604013773 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 713604013774 ATP binding site [chemical binding]; other site 713604013775 Walker A motif; other site 713604013776 Walker B motif; other site 713604013777 arginine finger; other site 713604013778 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 713604013779 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 713604013780 GTP binding site; other site 713604013781 Methyltransferase domain; Region: Methyltransf_12; pfam08242 713604013782 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604013783 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604013784 aconitate hydratase; Validated; Region: PRK09277 713604013785 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 713604013786 substrate binding site [chemical binding]; other site 713604013787 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 713604013788 ligand binding site [chemical binding]; other site 713604013789 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 713604013790 substrate binding site [chemical binding]; other site 713604013791 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 713604013792 MgtC family; Region: MgtC; pfam02308 713604013793 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604013794 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013795 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013796 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604013797 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604013798 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 713604013799 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 713604013800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604013801 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 713604013802 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 713604013803 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 713604013804 putative active site [active] 713604013805 putative dimer interface [polypeptide binding]; other site 713604013806 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 713604013807 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 713604013808 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604013809 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604013810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604013811 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604013812 putative dimerization interface [polypeptide binding]; other site 713604013813 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 713604013814 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 713604013815 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 713604013816 NAD(P) binding pocket [chemical binding]; other site 713604013817 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 713604013818 EspG family; Region: ESX-1_EspG; pfam14011 713604013819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013821 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 713604013822 Domain of unknown function DUF21; Region: DUF21; pfam01595 713604013823 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 713604013824 Transporter associated domain; Region: CorC_HlyC; smart01091 713604013825 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 713604013826 Domain of unknown function DUF21; Region: DUF21; pfam01595 713604013827 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 713604013828 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604013829 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604013830 active site 713604013831 catalytic tetrad [active] 713604013832 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604013833 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604013834 non-specific DNA binding site [nucleotide binding]; other site 713604013835 salt bridge; other site 713604013836 sequence-specific DNA binding site [nucleotide binding]; other site 713604013837 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604013838 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 713604013839 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604013840 NAD binding site [chemical binding]; other site 713604013841 substrate binding site [chemical binding]; other site 713604013842 active site 713604013843 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 713604013844 Ligand binding site; other site 713604013845 Putative Catalytic site; other site 713604013846 DXD motif; other site 713604013847 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604013848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604013849 NAD(P) binding site [chemical binding]; other site 713604013850 active site 713604013851 glycine dehydrogenase; Provisional; Region: PRK05367 713604013852 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 713604013853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604013854 tetramer interface [polypeptide binding]; other site 713604013855 catalytic residue [active] 713604013856 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 713604013857 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604013858 catalytic residue [active] 713604013859 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 713604013860 DNA binding residues [nucleotide binding] 713604013861 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604013862 putative dimer interface [polypeptide binding]; other site 713604013863 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 713604013864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013865 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 713604013866 catalytic residues [active] 713604013867 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 713604013868 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 713604013869 DNA binding residues [nucleotide binding] 713604013870 putative dimer interface [polypeptide binding]; other site 713604013871 Bifunctional nuclease; Region: DNase-RNase; pfam02577 713604013872 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604013873 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604013874 DNA binding residues [nucleotide binding] 713604013875 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 713604013876 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 713604013877 phosphopeptide binding site; other site 713604013878 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 713604013879 lipoyl attachment site [posttranslational modification]; other site 713604013880 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 713604013881 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 713604013882 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 713604013883 active site 713604013884 acyl-activating enzyme (AAE) consensus motif; other site 713604013885 putative CoA binding site [chemical binding]; other site 713604013886 AMP binding site [chemical binding]; other site 713604013887 enoyl-CoA hydratase; Provisional; Region: PRK06142 713604013888 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604013889 substrate binding site [chemical binding]; other site 713604013890 oxyanion hole (OAH) forming residues; other site 713604013891 trimer interface [polypeptide binding]; other site 713604013892 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604013893 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604013894 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 713604013895 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 713604013896 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 713604013897 homodimer interface [polypeptide binding]; other site 713604013898 active site 713604013899 SAM binding site [chemical binding]; other site 713604013900 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 713604013901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604013902 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604013903 Walker A motif; other site 713604013904 ATP binding site [chemical binding]; other site 713604013905 Walker B motif; other site 713604013906 arginine finger; other site 713604013907 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 713604013908 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 713604013909 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 713604013910 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604013911 MarR family; Region: MarR; pfam01047 713604013912 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604013913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604013914 putative substrate translocation pore; other site 713604013915 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 713604013916 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604013917 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 713604013918 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 713604013919 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604013920 catalytic residue [active] 713604013921 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 713604013922 MFS/sugar transport protein; Region: MFS_2; pfam13347 713604013923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604013924 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604013925 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 713604013926 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 713604013927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604013928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604013929 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604013930 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604013931 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604013932 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 713604013933 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 713604013934 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604013935 active site 713604013936 putative catalytic site [active] 713604013937 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 713604013938 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 713604013939 active site 713604013940 dimer interface [polypeptide binding]; other site 713604013941 non-prolyl cis peptide bond; other site 713604013942 insertion regions; other site 713604013943 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 713604013944 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604013945 substrate binding pocket [chemical binding]; other site 713604013946 membrane-bound complex binding site; other site 713604013947 hinge residues; other site 713604013948 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604013949 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604013950 Walker A/P-loop; other site 713604013951 ATP binding site [chemical binding]; other site 713604013952 Q-loop/lid; other site 713604013953 ABC transporter signature motif; other site 713604013954 Walker B; other site 713604013955 D-loop; other site 713604013956 H-loop/switch region; other site 713604013957 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604013958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604013959 putative PBP binding loops; other site 713604013960 ABC-ATPase subunit interface; other site 713604013961 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 713604013962 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604013963 active site 713604013964 motif 3; other site 713604013965 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 713604013966 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604013967 DinB superfamily; Region: DinB_2; pfam12867 713604013968 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604013969 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604013970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013971 Walker A/P-loop; other site 713604013972 ATP binding site [chemical binding]; other site 713604013973 Q-loop/lid; other site 713604013974 ABC transporter signature motif; other site 713604013975 Walker B; other site 713604013976 D-loop; other site 713604013977 H-loop/switch region; other site 713604013978 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604013979 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604013980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604013981 Walker A/P-loop; other site 713604013982 ATP binding site [chemical binding]; other site 713604013983 Q-loop/lid; other site 713604013984 ABC transporter signature motif; other site 713604013985 Walker B; other site 713604013986 D-loop; other site 713604013987 H-loop/switch region; other site 713604013988 MbtH-like protein; Region: MbtH; cl01279 713604013989 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 713604013990 intersubunit interface [polypeptide binding]; other site 713604013991 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 713604013992 tetramerization interface [polypeptide binding]; other site 713604013993 active site 713604013994 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604013995 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604013996 acyl-activating enzyme (AAE) consensus motif; other site 713604013997 AMP binding site [chemical binding]; other site 713604013998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604013999 S-adenosylmethionine binding site [chemical binding]; other site 713604014000 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014001 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014002 Condensation domain; Region: Condensation; pfam00668 713604014003 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604014004 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604014005 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604014006 acyl-activating enzyme (AAE) consensus motif; other site 713604014007 AMP binding site [chemical binding]; other site 713604014008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604014009 S-adenosylmethionine binding site [chemical binding]; other site 713604014010 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014011 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014012 Condensation domain; Region: Condensation; pfam00668 713604014013 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604014014 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604014015 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604014016 acyl-activating enzyme (AAE) consensus motif; other site 713604014017 AMP binding site [chemical binding]; other site 713604014018 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 713604014019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604014020 S-adenosylmethionine binding site [chemical binding]; other site 713604014021 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014022 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014023 Condensation domain; Region: Condensation; pfam00668 713604014024 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604014025 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604014026 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604014027 acyl-activating enzyme (AAE) consensus motif; other site 713604014028 AMP binding site [chemical binding]; other site 713604014029 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014030 Condensation domain; Region: Condensation; pfam00668 713604014031 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604014032 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604014033 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604014034 acyl-activating enzyme (AAE) consensus motif; other site 713604014035 AMP binding site [chemical binding]; other site 713604014036 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014037 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 713604014038 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 713604014039 ABC-ATPase subunit interface; other site 713604014040 dimer interface [polypeptide binding]; other site 713604014041 putative PBP binding regions; other site 713604014042 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 713604014043 ABC-ATPase subunit interface; other site 713604014044 dimer interface [polypeptide binding]; other site 713604014045 putative PBP binding regions; other site 713604014046 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 713604014047 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 713604014048 Walker A/P-loop; other site 713604014049 ATP binding site [chemical binding]; other site 713604014050 Q-loop/lid; other site 713604014051 ABC transporter signature motif; other site 713604014052 Walker B; other site 713604014053 D-loop; other site 713604014054 H-loop/switch region; other site 713604014055 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604014056 DinB superfamily; Region: DinB_2; pfam12867 713604014057 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 713604014058 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604014059 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 713604014060 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 713604014061 active site 713604014062 substrate binding site [chemical binding]; other site 713604014063 cosubstrate binding site; other site 713604014064 catalytic site [active] 713604014065 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 713604014066 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 713604014067 Melibiase; Region: Melibiase; pfam02065 713604014068 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604014069 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604014070 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604014071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014072 putative PBP binding loops; other site 713604014073 ABC-ATPase subunit interface; other site 713604014074 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604014075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014076 dimer interface [polypeptide binding]; other site 713604014077 conserved gate region; other site 713604014078 putative PBP binding loops; other site 713604014079 ABC-ATPase subunit interface; other site 713604014080 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 713604014081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604014082 Walker A/P-loop; other site 713604014083 ATP binding site [chemical binding]; other site 713604014084 Q-loop/lid; other site 713604014085 ABC transporter signature motif; other site 713604014086 Walker B; other site 713604014087 D-loop; other site 713604014088 H-loop/switch region; other site 713604014089 ABC transporter; Region: ABC_tran_2; pfam12848 713604014090 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604014091 PaaX-like protein; Region: PaaX; pfam07848 713604014092 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 713604014093 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604014094 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604014095 substrate binding site [chemical binding]; other site 713604014096 oxyanion hole (OAH) forming residues; other site 713604014097 trimer interface [polypeptide binding]; other site 713604014098 CBD_II domain; Region: CBD_II; smart00637 713604014099 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604014100 Interdomain contacts; other site 713604014101 Cytokine receptor motif; other site 713604014102 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604014103 Interdomain contacts; other site 713604014104 Cytokine receptor motif; other site 713604014105 Glyco_18 domain; Region: Glyco_18; smart00636 713604014106 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 713604014107 active site 713604014108 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604014109 DNA binding site [nucleotide binding] 713604014110 active site 713604014111 Int/Topo IB signature motif; other site 713604014112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604014113 Transposase; Region: HTH_Tnp_1; pfam01527 713604014114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 713604014115 HTH-like domain; Region: HTH_21; pfam13276 713604014116 Integrase core domain; Region: rve; pfam00665 713604014117 Integrase core domain; Region: rve_3; pfam13683 713604014118 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 713604014119 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604014120 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014121 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014122 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014123 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014124 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014125 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014126 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014127 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014128 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014129 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014130 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014132 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014133 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604014134 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604014136 binding surface 713604014137 TPR motif; other site 713604014138 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604014140 binding surface 713604014141 TPR motif; other site 713604014142 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014143 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604014145 binding surface 713604014146 TPR motif; other site 713604014147 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604014148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 713604014149 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604014150 DNA binding site [nucleotide binding] 713604014151 Int/Topo IB signature motif; other site 713604014152 active site 713604014153 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 713604014154 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604014155 active site 713604014156 metal binding site [ion binding]; metal-binding site 713604014157 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 713604014158 active site 713604014159 catalytic residues [active] 713604014160 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 713604014161 MarR family; Region: MarR_2; pfam12802 713604014162 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604014163 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604014164 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 713604014165 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 713604014166 active site 713604014167 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604014168 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604014169 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604014170 Cellulose binding domain; Region: CBM_2; cl17741 713604014171 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 713604014172 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604014173 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 713604014174 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604014175 DNA interaction; other site 713604014176 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604014177 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 713604014178 metal binding site [ion binding]; metal-binding site 713604014179 substrate binding pocket [chemical binding]; other site 713604014180 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 713604014181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604014182 DNA binding site [nucleotide binding] 713604014183 domain linker motif; other site 713604014184 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604014185 dimerization interface [polypeptide binding]; other site 713604014186 ligand binding site [chemical binding]; other site 713604014187 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 713604014188 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604014189 metal binding site [ion binding]; metal-binding site 713604014190 substrate binding pocket [chemical binding]; other site 713604014191 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604014192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014193 dimer interface [polypeptide binding]; other site 713604014194 conserved gate region; other site 713604014195 putative PBP binding loops; other site 713604014196 ABC-ATPase subunit interface; other site 713604014197 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 713604014198 NMT1/THI5 like; Region: NMT1; pfam09084 713604014199 substrate binding pocket [chemical binding]; other site 713604014200 membrane-bound complex binding site; other site 713604014201 hinge residues; other site 713604014202 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604014203 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604014204 Walker A/P-loop; other site 713604014205 ATP binding site [chemical binding]; other site 713604014206 Q-loop/lid; other site 713604014207 ABC transporter signature motif; other site 713604014208 Walker B; other site 713604014209 D-loop; other site 713604014210 H-loop/switch region; other site 713604014211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604014212 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604014213 dimerization interface [polypeptide binding]; other site 713604014214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604014215 dimer interface [polypeptide binding]; other site 713604014216 phosphorylation site [posttranslational modification] 713604014217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604014218 Mg2+ binding site [ion binding]; other site 713604014219 G-X-G motif; other site 713604014220 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604014221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604014222 active site 713604014223 phosphorylation site [posttranslational modification] 713604014224 intermolecular recognition site; other site 713604014225 dimerization interface [polypeptide binding]; other site 713604014226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604014227 DNA binding site [nucleotide binding] 713604014228 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604014229 MarR family; Region: MarR_2; pfam12802 713604014230 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604014231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014232 putative substrate translocation pore; other site 713604014233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604014234 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604014235 MarR family; Region: MarR_2; cl17246 713604014236 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 713604014237 amphipathic channel; other site 713604014238 Asn-Pro-Ala signature motifs; other site 713604014239 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604014240 iron-sulfur cluster [ion binding]; other site 713604014241 [2Fe-2S] cluster binding site [ion binding]; other site 713604014242 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 713604014243 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 713604014244 PYR/PP interface [polypeptide binding]; other site 713604014245 dimer interface [polypeptide binding]; other site 713604014246 tetramer interface [polypeptide binding]; other site 713604014247 TPP binding site [chemical binding]; other site 713604014248 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604014249 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604014250 TPP-binding site [chemical binding]; other site 713604014251 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604014252 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604014253 classical (c) SDRs; Region: SDR_c; cd05233 713604014254 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604014255 NAD(P) binding site [chemical binding]; other site 713604014256 active site 713604014257 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 713604014258 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604014259 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604014260 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 713604014261 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604014262 active site 713604014263 metal binding site [ion binding]; metal-binding site 713604014264 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604014265 active site 713604014266 metal binding site [ion binding]; metal-binding site 713604014267 hypothetical protein; Provisional; Region: PRK06847 713604014268 hypothetical protein; Provisional; Region: PRK07236 713604014269 Putative cyclase; Region: Cyclase; pfam04199 713604014270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604014271 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604014272 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 713604014273 substrate binding pocket [chemical binding]; other site 713604014274 dimerization interface [polypeptide binding]; other site 713604014275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604014276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014277 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604014278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604014279 Walker A/P-loop; other site 713604014280 ATP binding site [chemical binding]; other site 713604014281 Q-loop/lid; other site 713604014282 ABC transporter signature motif; other site 713604014283 Walker B; other site 713604014284 D-loop; other site 713604014285 H-loop/switch region; other site 713604014286 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604014287 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604014288 TM-ABC transporter signature motif; other site 713604014289 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604014290 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604014291 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604014292 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604014293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604014294 DNA binding residues [nucleotide binding] 713604014295 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 713604014296 peptidase domain interface [polypeptide binding]; other site 713604014297 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604014298 active site 713604014299 catalytic triad [active] 713604014300 calcium binding site [ion binding]; other site 713604014301 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 713604014302 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604014303 active site 713604014304 catalytic triad [active] 713604014305 oxyanion hole [active] 713604014306 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 713604014307 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 713604014308 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604014309 active site 713604014310 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 713604014311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604014312 FeS/SAM binding site; other site 713604014313 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604014314 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604014315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 713604014316 active site 713604014317 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 713604014318 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604014319 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604014320 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604014321 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604014322 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604014323 Cytochrome P450; Region: p450; cl12078 713604014324 CsbD-like; Region: CsbD; pfam05532 713604014325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604014326 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 713604014327 NAD(P) binding site [chemical binding]; other site 713604014328 active site 713604014329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604014330 sequence-specific DNA binding site [nucleotide binding]; other site 713604014331 salt bridge; other site 713604014332 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604014333 G1 box; other site 713604014334 GTP/Mg2+ binding site [chemical binding]; other site 713604014335 G2 box; other site 713604014336 Switch I region; other site 713604014337 G3 box; other site 713604014338 Switch II region; other site 713604014339 G4 box; other site 713604014340 G5 box; other site 713604014341 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 713604014342 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 713604014343 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 713604014344 selenocysteine synthase; Provisional; Region: PRK04311 713604014345 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604014346 selenium donor protein; Region: selD; TIGR00476 713604014347 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 713604014348 dimerization interface [polypeptide binding]; other site 713604014349 putative ATP binding site [chemical binding]; other site 713604014350 hypothetical protein; Provisional; Region: PRK06771 713604014351 Isochorismatase family; Region: Isochorismatase; pfam00857 713604014352 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 713604014353 catalytic triad [active] 713604014354 conserved cis-peptide bond; other site 713604014355 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 713604014356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604014357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604014358 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 713604014359 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 713604014360 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 713604014361 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604014362 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604014363 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 713604014364 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604014365 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604014366 Predicted membrane protein [Function unknown]; Region: COG2259 713604014367 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 713604014368 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604014369 putative active site [active] 713604014370 putative metal binding site [ion binding]; other site 713604014371 Peptidase M15; Region: Peptidase_M15_3; cl01194 713604014372 haloalkane dehalogenase; Provisional; Region: PRK03592 713604014373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604014374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014375 RibD C-terminal domain; Region: RibD_C; cl17279 713604014376 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 713604014377 Sulfatase; Region: Sulfatase; cl17466 713604014378 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 713604014379 VanZ like family; Region: VanZ; pfam04892 713604014380 RDD family; Region: RDD; pfam06271 713604014381 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604014382 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604014383 anti sigma factor interaction site; other site 713604014384 regulatory phosphorylation site [posttranslational modification]; other site 713604014385 MMPL family; Region: MMPL; pfam03176 713604014386 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604014387 MarR family; Region: MarR_2; pfam12802 713604014388 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 713604014389 spermidine synthase; Provisional; Region: PRK00811 713604014390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604014391 S-adenosylmethionine binding site [chemical binding]; other site 713604014392 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 713604014393 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 713604014394 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 713604014395 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604014396 catalytic residue [active] 713604014397 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 713604014398 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604014399 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604014400 putative sugar binding sites [chemical binding]; other site 713604014401 Q-X-W motif; other site 713604014402 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 713604014403 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604014404 MarR family; Region: MarR_2; cl17246 713604014405 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 713604014406 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014407 acyl-activating enzyme (AAE) consensus motif; other site 713604014408 active site 713604014409 AMP binding site [chemical binding]; other site 713604014410 CoA binding site [chemical binding]; other site 713604014411 TPR repeat; Region: TPR_11; pfam13414 713604014412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604014413 binding surface 713604014414 TPR motif; other site 713604014415 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 713604014416 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604014417 anti sigma factor interaction site; other site 713604014418 regulatory phosphorylation site [posttranslational modification]; other site 713604014419 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 713604014420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604014421 active site 713604014422 phosphorylation site [posttranslational modification] 713604014423 intermolecular recognition site; other site 713604014424 dimerization interface [polypeptide binding]; other site 713604014425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604014426 PAS domain; Region: PAS_9; pfam13426 713604014427 putative active site [active] 713604014428 heme pocket [chemical binding]; other site 713604014429 PAS domain S-box; Region: sensory_box; TIGR00229 713604014430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604014431 putative active site [active] 713604014432 heme pocket [chemical binding]; other site 713604014433 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604014434 Histidine kinase; Region: HisKA_3; pfam07730 713604014435 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604014436 ATP binding site [chemical binding]; other site 713604014437 Mg2+ binding site [ion binding]; other site 713604014438 G-X-G motif; other site 713604014439 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604014440 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604014441 cheY-homologous receiver domain; Region: REC; smart00448 713604014442 active site 713604014443 phosphorylation site [posttranslational modification] 713604014444 intermolecular recognition site; other site 713604014445 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604014446 DNA binding residues [nucleotide binding] 713604014447 dimerization interface [polypeptide binding]; other site 713604014448 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 713604014449 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 713604014450 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 713604014451 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 713604014452 nucleotide binding site [chemical binding]; other site 713604014453 putative NEF/HSP70 interaction site [polypeptide binding]; other site 713604014454 SBD interface [polypeptide binding]; other site 713604014455 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604014456 Dynamin family; Region: Dynamin_N; pfam00350 713604014457 G1 box; other site 713604014458 GTP/Mg2+ binding site [chemical binding]; other site 713604014459 G2 box; other site 713604014460 Switch I region; other site 713604014461 G3 box; other site 713604014462 Switch II region; other site 713604014463 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 713604014464 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 713604014465 Dynamin family; Region: Dynamin_N; pfam00350 713604014466 G1 box; other site 713604014467 G1 box; other site 713604014468 GTP/Mg2+ binding site [chemical binding]; other site 713604014469 GTP/Mg2+ binding site [chemical binding]; other site 713604014470 G2 box; other site 713604014471 Switch I region; other site 713604014472 G3 box; other site 713604014473 Switch II region; other site 713604014474 G4 box; other site 713604014475 G5 box; other site 713604014476 Predicted ATPase [General function prediction only]; Region: COG3899 713604014477 AAA ATPase domain; Region: AAA_16; pfam13191 713604014478 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604014479 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604014480 DNA binding residues [nucleotide binding] 713604014481 dimerization interface [polypeptide binding]; other site 713604014482 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 713604014483 active site 713604014484 catalytic site [active] 713604014485 hypothetical protein; Provisional; Region: PRK07236 713604014486 hypothetical protein; Provisional; Region: PRK07588 713604014487 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 713604014488 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 713604014489 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 713604014490 substrate binding pocket [chemical binding]; other site 713604014491 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 713604014492 B12 binding site [chemical binding]; other site 713604014493 cobalt ligand [ion binding]; other site 713604014494 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 713604014495 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604014496 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604014497 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 713604014498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014499 putative substrate translocation pore; other site 713604014500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014501 Cellulose binding domain; Region: CBM_2; pfam00553 713604014502 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 713604014503 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604014504 putative NAD(P) binding site [chemical binding]; other site 713604014505 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 713604014506 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 713604014507 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604014508 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 713604014509 Cellulose binding domain; Region: CBM_2; pfam00553 713604014510 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604014511 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604014512 active site 713604014513 catalytic tetrad [active] 713604014514 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 713604014515 putative active cleft [active] 713604014516 dimerization interface [polypeptide binding]; other site 713604014517 Chitin binding domain; Region: Chitin_bind_3; pfam03067 713604014518 Cellulose binding domain; Region: CBM_2; pfam00553 713604014519 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604014520 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604014521 DNA binding site [nucleotide binding] 713604014522 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604014523 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 713604014524 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604014525 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604014526 Cellulose binding domain; Region: CBM_2; pfam00553 713604014527 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 713604014528 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 713604014529 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 713604014530 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604014531 Cellulose binding domain; Region: CBM_2; pfam00553 713604014532 Cellulose binding domain; Region: CBM_2; pfam00553 713604014533 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 713604014534 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604014535 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604014536 DNA binding site [nucleotide binding] 713604014537 domain linker motif; other site 713604014538 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604014539 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604014540 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604014541 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 713604014542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014543 dimer interface [polypeptide binding]; other site 713604014544 conserved gate region; other site 713604014545 ABC-ATPase subunit interface; other site 713604014546 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604014547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014548 dimer interface [polypeptide binding]; other site 713604014549 conserved gate region; other site 713604014550 putative PBP binding loops; other site 713604014551 ABC-ATPase subunit interface; other site 713604014552 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604014553 beta-galactosidase; Region: BGL; TIGR03356 713604014554 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 713604014555 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 713604014556 FOG: CBS domain [General function prediction only]; Region: COG0517 713604014557 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 713604014558 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 713604014559 Fe-S cluster binding site [ion binding]; other site 713604014560 active site 713604014561 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 713604014562 nucleotide binding site [chemical binding]; other site 713604014563 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 713604014564 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 713604014565 active site 713604014566 DNA binding site [nucleotide binding] 713604014567 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 713604014568 DNA binding site [nucleotide binding] 713604014569 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 713604014570 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 713604014571 putative DNA binding site [nucleotide binding]; other site 713604014572 putative homodimer interface [polypeptide binding]; other site 713604014573 GAF domain; Region: GAF_2; pfam13185 713604014574 GAF domain; Region: GAF; pfam01590 713604014575 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 713604014576 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604014577 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 713604014578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604014579 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604014580 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 713604014581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604014582 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604014583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604014584 DNA binding residues [nucleotide binding] 713604014585 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 713604014586 putative active site; other site 713604014587 putative metal binding residues [ion binding]; other site 713604014588 signature motif; other site 713604014589 putative triphosphate binding site [ion binding]; other site 713604014590 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 713604014591 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 713604014592 ANTAR domain; Region: ANTAR; pfam03861 713604014593 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 713604014594 putative hydrophobic ligand binding site [chemical binding]; other site 713604014595 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 713604014596 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 713604014597 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604014598 anti sigma factor interaction site; other site 713604014599 regulatory phosphorylation site [posttranslational modification]; other site 713604014600 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 713604014601 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604014602 Amidinotransferase; Region: Amidinotransf; cl12043 713604014603 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604014604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604014605 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604014606 dimerization interface [polypeptide binding]; other site 713604014607 substrate binding pocket [chemical binding]; other site 713604014608 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 713604014609 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 713604014610 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604014611 catalytic residue [active] 713604014612 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 713604014613 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 713604014614 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 713604014615 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 713604014616 active site 713604014617 catalytic triad [active] 713604014618 oxyanion hole [active] 713604014619 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604014620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014621 putative substrate translocation pore; other site 713604014622 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604014623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604014624 Coenzyme A binding pocket [chemical binding]; other site 713604014625 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604014626 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604014627 RHS Repeat; Region: RHS_repeat; pfam05593 713604014628 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604014629 RHS Repeat; Region: RHS_repeat; pfam05593 713604014630 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 713604014631 RHS Repeat; Region: RHS_repeat; cl11982 713604014632 RHS Repeat; Region: RHS_repeat; pfam05593 713604014633 RHS protein; Region: RHS; pfam03527 713604014634 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604014635 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 713604014636 EspG family; Region: ESX-1_EspG; pfam14011 713604014637 Domain of unknown function (DUF222); Region: DUF222; pfam02720 713604014638 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604014639 active site 713604014640 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 713604014641 Flavin Reductases; Region: FlaRed; cl00801 713604014642 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604014643 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 713604014644 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604014645 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 713604014646 catalytic loop [active] 713604014647 iron binding site [ion binding]; other site 713604014648 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604014649 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604014650 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604014651 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604014652 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 713604014653 RibD C-terminal domain; Region: RibD_C; cl17279 713604014654 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604014655 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014656 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604014657 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604014658 DNA binding site [nucleotide binding] 713604014659 domain linker motif; other site 713604014660 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604014661 dimerization interface [polypeptide binding]; other site 713604014662 ligand binding site [chemical binding]; other site 713604014663 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014664 sugar binding site [chemical binding]; other site 713604014665 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014666 sugar binding site [chemical binding]; other site 713604014667 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604014668 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604014669 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604014670 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604014671 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014672 sugar binding site [chemical binding]; other site 713604014673 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014674 sugar binding site [chemical binding]; other site 713604014675 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 713604014676 active site 713604014677 catalytic residues [active] 713604014678 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604014679 sugar binding site [chemical binding]; other site 713604014680 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604014681 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604014682 MarR family; Region: MarR; pfam01047 713604014683 MarR family; Region: MarR_2; cl17246 713604014684 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 713604014685 dimerization interface [polypeptide binding]; other site 713604014686 active site 713604014687 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 713604014688 substrate binding site [chemical binding]; other site 713604014689 THF binding site; other site 713604014690 zinc-binding site [ion binding]; other site 713604014691 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 713604014692 DNA polymerase IV; Validated; Region: PRK03352 713604014693 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 713604014694 active site 713604014695 DNA binding site [nucleotide binding] 713604014696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604014697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014698 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 713604014699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604014700 Coenzyme A binding pocket [chemical binding]; other site 713604014701 Adenosylhomocysteinase; Provisional; Region: PTZ00075 713604014702 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 713604014703 homotetramer interface [polypeptide binding]; other site 713604014704 ligand binding site [chemical binding]; other site 713604014705 catalytic site [active] 713604014706 NAD binding site [chemical binding]; other site 713604014707 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 713604014708 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 713604014709 putative DNA binding site [nucleotide binding]; other site 713604014710 putative homodimer interface [polypeptide binding]; other site 713604014711 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604014712 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604014713 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604014714 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604014715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604014716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604014717 ATP binding site [chemical binding]; other site 713604014718 Mg2+ binding site [ion binding]; other site 713604014719 G-X-G motif; other site 713604014720 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604014721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014722 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604014723 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604014724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604014725 Walker A/P-loop; other site 713604014726 ATP binding site [chemical binding]; other site 713604014727 Q-loop/lid; other site 713604014728 ABC transporter signature motif; other site 713604014729 Walker B; other site 713604014730 D-loop; other site 713604014731 H-loop/switch region; other site 713604014732 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604014733 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604014734 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 713604014735 Walker A/P-loop; other site 713604014736 ATP binding site [chemical binding]; other site 713604014737 Q-loop/lid; other site 713604014738 ABC transporter signature motif; other site 713604014739 Walker B; other site 713604014740 D-loop; other site 713604014741 H-loop/switch region; other site 713604014742 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 713604014743 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 713604014744 active site 713604014745 DNA binding site [nucleotide binding] 713604014746 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604014747 AAA ATPase domain; Region: AAA_16; pfam13191 713604014748 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 713604014749 conserved cys residue [active] 713604014750 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 713604014751 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604014752 conserved cys residue [active] 713604014753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604014754 YibE/F-like protein; Region: YibE_F; pfam07907 713604014755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 713604014756 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 713604014757 active site 713604014758 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 713604014759 AAA domain; Region: AAA_17; pfam13207 713604014760 enoyl-CoA hydratase; Provisional; Region: PRK06127 713604014761 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604014762 substrate binding site [chemical binding]; other site 713604014763 oxyanion hole (OAH) forming residues; other site 713604014764 trimer interface [polypeptide binding]; other site 713604014765 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604014766 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604014767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604014768 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604014769 DNA binding residues [nucleotide binding] 713604014770 dimerization interface [polypeptide binding]; other site 713604014771 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 713604014772 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 713604014773 MarR family; Region: MarR_2; pfam12802 713604014774 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604014775 hypothetical protein; Provisional; Region: PRK08204 713604014776 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604014777 active site 713604014778 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 713604014779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604014780 Zn2+ binding site [ion binding]; other site 713604014781 Mg2+ binding site [ion binding]; other site 713604014782 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 713604014783 synthetase active site [active] 713604014784 NTP binding site [chemical binding]; other site 713604014785 metal binding site [ion binding]; metal-binding site 713604014786 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 713604014787 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 713604014788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604014789 active site 713604014790 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 713604014791 Protein export membrane protein; Region: SecD_SecF; cl14618 713604014792 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 713604014793 Protein export membrane protein; Region: SecD_SecF; cl14618 713604014794 Preprotein translocase subunit; Region: YajC; cl00806 713604014795 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 713604014796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604014797 Walker A motif; other site 713604014798 ATP binding site [chemical binding]; other site 713604014799 Walker B motif; other site 713604014800 arginine finger; other site 713604014801 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 713604014802 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 713604014803 RuvA N terminal domain; Region: RuvA_N; pfam01330 713604014804 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 713604014805 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 713604014806 active site 713604014807 putative DNA-binding cleft [nucleotide binding]; other site 713604014808 dimer interface [polypeptide binding]; other site 713604014809 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 713604014810 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 713604014811 hypothetical protein; Validated; Region: PRK00110 713604014812 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 713604014813 predicted active site [active] 713604014814 catalytic triad [active] 713604014815 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 713604014816 AzlC protein; Region: AzlC; pfam03591 713604014817 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604014818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604014819 non-specific DNA binding site [nucleotide binding]; other site 713604014820 salt bridge; other site 713604014821 sequence-specific DNA binding site [nucleotide binding]; other site 713604014822 Cupin domain; Region: Cupin_2; cl17218 713604014823 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 713604014824 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604014825 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604014826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604014827 active site 713604014828 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604014829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014830 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604014831 acyl-activating enzyme (AAE) consensus motif; other site 713604014832 AMP binding site [chemical binding]; other site 713604014833 active site 713604014834 CoA binding site [chemical binding]; other site 713604014835 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604014836 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604014837 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 713604014838 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 713604014839 active site 713604014840 multimer interface [polypeptide binding]; other site 713604014841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604014842 putative Zn2+ binding site [ion binding]; other site 713604014843 putative DNA binding site [nucleotide binding]; other site 713604014844 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604014845 FAD binding domain; Region: FAD_binding_4; pfam01565 713604014846 Berberine and berberine like; Region: BBE; pfam08031 713604014847 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 713604014848 elongation factor G; Reviewed; Region: PRK12740 713604014849 G1 box; other site 713604014850 putative GEF interaction site [polypeptide binding]; other site 713604014851 GTP/Mg2+ binding site [chemical binding]; other site 713604014852 Switch I region; other site 713604014853 G2 box; other site 713604014854 G3 box; other site 713604014855 Switch II region; other site 713604014856 G4 box; other site 713604014857 G5 box; other site 713604014858 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 713604014859 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 713604014860 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 713604014861 XdhC Rossmann domain; Region: XdhC_C; pfam13478 713604014862 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604014863 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604014864 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 713604014865 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 713604014866 putative acyl-acceptor binding pocket; other site 713604014867 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 713604014868 MarR family; Region: MarR_2; pfam12802 713604014869 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 713604014870 nucleotide binding site/active site [active] 713604014871 HIT family signature motif; other site 713604014872 catalytic residue [active] 713604014873 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 713604014874 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 713604014875 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 713604014876 active site 713604014877 dimer interface [polypeptide binding]; other site 713604014878 motif 1; other site 713604014879 motif 2; other site 713604014880 motif 3; other site 713604014881 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 713604014882 anticodon binding site; other site 713604014883 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 713604014884 putative FMN binding site [chemical binding]; other site 713604014885 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 713604014886 Bacterial sugar transferase; Region: Bac_transf; pfam02397 713604014887 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 713604014888 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604014889 active site 713604014890 DNA binding site [nucleotide binding] 713604014891 Int/Topo IB signature motif; other site 713604014892 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604014893 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604014894 Peptidase family M41; Region: Peptidase_M41; pfam01434 713604014895 Predicted permease; Region: DUF318; pfam03773 713604014896 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 713604014897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604014898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014899 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604014900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604014901 NAD(P) binding site [chemical binding]; other site 713604014902 active site 713604014903 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604014904 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604014905 substrate binding site [chemical binding]; other site 713604014906 oxyanion hole (OAH) forming residues; other site 713604014907 trimer interface [polypeptide binding]; other site 713604014908 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 713604014909 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014910 acyl-activating enzyme (AAE) consensus motif; other site 713604014911 AMP binding site [chemical binding]; other site 713604014912 active site 713604014913 CoA binding site [chemical binding]; other site 713604014914 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 713604014915 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604014916 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 713604014917 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 713604014918 metal binding site [ion binding]; metal-binding site 713604014919 dimer interface [polypeptide binding]; other site 713604014920 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604014921 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604014922 AsnC family; Region: AsnC_trans_reg; pfam01037 713604014923 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604014924 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604014925 AsnC family; Region: AsnC_trans_reg; pfam01037 713604014926 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604014927 MarR family; Region: MarR_2; pfam12802 713604014928 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604014929 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604014930 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604014931 active site 713604014932 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604014933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604014934 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604014935 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 713604014936 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604014937 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604014938 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604014939 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604014940 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 713604014941 acyl-activating enzyme (AAE) consensus motif; other site 713604014942 putative AMP binding site [chemical binding]; other site 713604014943 putative active site [active] 713604014944 putative CoA binding site [chemical binding]; other site 713604014945 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604014946 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604014947 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 713604014948 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 713604014949 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 713604014950 putative active site [active] 713604014951 putative metal binding site [ion binding]; other site 713604014952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604014953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014954 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 713604014955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604014956 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604014957 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 713604014958 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 713604014959 Predicted amidohydrolase [General function prediction only]; Region: COG0388 713604014960 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 713604014961 active site 713604014962 catalytic triad [active] 713604014963 dimer interface [polypeptide binding]; other site 713604014964 Right handed beta helix region; Region: Beta_helix; pfam13229 713604014965 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 713604014966 active site 713604014967 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 713604014968 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 713604014969 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604014970 putative ligand binding site [chemical binding]; other site 713604014971 putative NAD binding site [chemical binding]; other site 713604014972 catalytic site [active] 713604014973 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604014974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604014975 dimer interface [polypeptide binding]; other site 713604014976 conserved gate region; other site 713604014977 putative PBP binding loops; other site 713604014978 ABC-ATPase subunit interface; other site 713604014979 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 713604014980 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604014981 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604014982 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 713604014983 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604014984 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604014985 ligand binding site [chemical binding]; other site 713604014986 dimerization interface [polypeptide binding]; other site 713604014987 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604014988 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604014989 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 713604014990 Strictosidine synthase; Region: Str_synth; pfam03088 713604014991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604014993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604014994 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 713604014995 classical (c) SDRs; Region: SDR_c; cd05233 713604014996 NAD(P) binding site [chemical binding]; other site 713604014997 active site 713604014998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604014999 NAD(P) binding site [chemical binding]; other site 713604015000 active site 713604015001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015003 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 713604015004 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604015005 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 713604015006 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 713604015007 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 713604015008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015009 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604015010 putative substrate translocation pore; other site 713604015011 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 713604015012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604015013 DNA-binding site [nucleotide binding]; DNA binding site 713604015014 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604015015 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 713604015016 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 713604015017 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604015018 Coenzyme A binding pocket [chemical binding]; other site 713604015019 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 713604015020 RHS Repeat; Region: RHS_repeat; cl11982 713604015021 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604015022 RHS Repeat; Region: RHS_repeat; cl11982 713604015023 RHS Repeat; Region: RHS_repeat; pfam05593 713604015024 RHS Repeat; Region: RHS_repeat; pfam05593 713604015025 RHS Repeat; Region: RHS_repeat; pfam05593 713604015026 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604015027 pyranose oxidase; Region: pyranose_ox; TIGR02462 713604015028 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604015029 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 713604015030 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 713604015031 substrate binding site; other site 713604015032 tetramer interface; other site 713604015033 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604015034 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604015035 acyl-activating enzyme (AAE) consensus motif; other site 713604015036 AMP binding site [chemical binding]; other site 713604015037 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604015038 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604015039 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604015040 Condensation domain; Region: Condensation; pfam00668 713604015041 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604015042 Neocarzinostatin family; Region: Neocarzinostat; pfam00960 713604015043 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015044 homodimer interface [polypeptide binding]; other site 713604015045 active site 713604015046 TDP-binding site; other site 713604015047 acceptor substrate-binding pocket; other site 713604015048 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604015049 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 713604015050 O-methyltransferase; Region: Methyltransf_2; pfam00891 713604015051 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 713604015052 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 713604015053 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015055 active site 713604015056 phosphorylation site [posttranslational modification] 713604015057 intermolecular recognition site; other site 713604015058 dimerization interface [polypeptide binding]; other site 713604015059 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015060 dimerization interface [polypeptide binding]; other site 713604015061 DNA binding residues [nucleotide binding] 713604015062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604015063 Histidine kinase; Region: HisKA_3; pfam07730 713604015064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015065 ATP binding site [chemical binding]; other site 713604015066 G-X-G motif; other site 713604015067 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604015068 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604015069 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604015070 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604015071 Walker A/P-loop; other site 713604015072 ATP binding site [chemical binding]; other site 713604015073 Q-loop/lid; other site 713604015074 ABC transporter signature motif; other site 713604015075 Walker B; other site 713604015076 D-loop; other site 713604015077 H-loop/switch region; other site 713604015078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015079 NAD(P) binding site [chemical binding]; other site 713604015080 active site 713604015081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604015083 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604015084 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604015085 acyl-activating enzyme (AAE) consensus motif; other site 713604015086 AMP binding site [chemical binding]; other site 713604015087 active site 713604015088 CoA binding site [chemical binding]; other site 713604015089 Condensation domain; Region: Condensation; pfam00668 713604015090 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604015091 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015092 homodimer interface [polypeptide binding]; other site 713604015093 active site 713604015094 TDP-binding site; other site 713604015095 acceptor substrate-binding pocket; other site 713604015096 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015097 homodimer interface [polypeptide binding]; other site 713604015098 active site 713604015099 TDP-binding site; other site 713604015100 acceptor substrate-binding pocket; other site 713604015101 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604015102 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015103 homodimer interface [polypeptide binding]; other site 713604015104 active site 713604015105 TDP-binding site; other site 713604015106 acceptor substrate-binding pocket; other site 713604015107 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604015108 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015109 homodimer interface [polypeptide binding]; other site 713604015110 active site 713604015111 TDP-binding site; other site 713604015112 acceptor substrate-binding pocket; other site 713604015113 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604015114 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015115 homodimer interface [polypeptide binding]; other site 713604015116 active site 713604015117 TDP-binding site; other site 713604015118 acceptor substrate-binding pocket; other site 713604015119 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604015120 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604015121 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604015122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604015123 Walker A/P-loop; other site 713604015124 ATP binding site [chemical binding]; other site 713604015125 Q-loop/lid; other site 713604015126 ABC transporter signature motif; other site 713604015127 Walker B; other site 713604015128 D-loop; other site 713604015129 H-loop/switch region; other site 713604015130 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604015131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604015132 S-adenosylmethionine binding site [chemical binding]; other site 713604015133 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604015134 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015135 homodimer interface [polypeptide binding]; other site 713604015136 active site 713604015137 TDP-binding site; other site 713604015138 acceptor substrate-binding pocket; other site 713604015139 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015140 homodimer interface [polypeptide binding]; other site 713604015141 active site 713604015142 TDP-binding site; other site 713604015143 acceptor substrate-binding pocket; other site 713604015144 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 713604015145 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 713604015146 inhibitor-cofactor binding pocket; inhibition site 713604015147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604015148 catalytic residue [active] 713604015149 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604015150 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604015151 AAA ATPase domain; Region: AAA_16; pfam13191 713604015152 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015153 homodimer interface [polypeptide binding]; other site 713604015154 active site 713604015155 TDP-binding site; other site 713604015156 acceptor substrate-binding pocket; other site 713604015157 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 713604015158 hypothetical protein; Provisional; Region: PRK08296 713604015159 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 713604015160 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 713604015161 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604015162 SchA/CurD like domain; Region: SchA_CurD; pfam04486 713604015163 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604015164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015165 NAD(P) binding site [chemical binding]; other site 713604015166 active site 713604015167 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 713604015168 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 713604015169 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 713604015170 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 713604015171 classical (c) SDRs; Region: SDR_c; cd05233 713604015172 NAD(P) binding site [chemical binding]; other site 713604015173 active site 713604015174 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 713604015175 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 713604015176 putative hydrophobic ligand binding site [chemical binding]; other site 713604015177 active site 713604015178 catalytic residues_2 [active] 713604015179 catalytic residues_1 [active] 713604015180 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604015181 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 713604015182 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 713604015183 active site 713604015184 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 713604015185 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 713604015186 dimer interface [polypeptide binding]; other site 713604015187 active site 713604015188 Cupin domain; Region: Cupin_2; pfam07883 713604015189 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 713604015190 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604015191 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604015192 POT family; Region: PTR2; cl17359 713604015193 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 713604015194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604015195 S-adenosylmethionine binding site [chemical binding]; other site 713604015196 hypothetical protein; Provisional; Region: PRK06126 713604015197 hypothetical protein; Provisional; Region: PRK07236 713604015198 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604015199 FAD binding domain; Region: FAD_binding_3; pfam01494 713604015200 hypothetical protein; Provisional; Region: PRK07236 713604015201 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 713604015202 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 713604015203 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 713604015204 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604015205 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604015206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015207 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604015208 NAD(P) binding site [chemical binding]; other site 713604015209 active site 713604015210 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604015211 Cytochrome P450; Region: p450; cl12078 713604015212 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604015213 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604015214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604015215 S-adenosylmethionine binding site [chemical binding]; other site 713604015216 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604015217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015218 NAD(P) binding site [chemical binding]; other site 713604015219 active site 713604015220 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604015221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015222 NAD(P) binding site [chemical binding]; other site 713604015223 active site 713604015224 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604015225 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604015226 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604015227 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604015228 putative sugar binding sites [chemical binding]; other site 713604015229 Q-X-W motif; other site 713604015230 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604015231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604015232 non-specific DNA binding site [nucleotide binding]; other site 713604015233 salt bridge; other site 713604015234 sequence-specific DNA binding site [nucleotide binding]; other site 713604015235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604015236 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604015237 binding surface 713604015238 TPR motif; other site 713604015239 RHS Repeat; Region: RHS_repeat; pfam05593 713604015240 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604015241 RHS Repeat; Region: RHS_repeat; pfam05593 713604015242 RHS Repeat; Region: RHS_repeat; pfam05593 713604015243 RHS Repeat; Region: RHS_repeat; pfam05593 713604015244 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604015245 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 713604015246 dimer interface [polypeptide binding]; other site 713604015247 Short C-terminal domain; Region: SHOCT; pfam09851 713604015248 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 713604015249 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 713604015250 Sulfate transporter family; Region: Sulfate_transp; pfam00916 713604015251 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 713604015252 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015253 Ligand Binding Site [chemical binding]; other site 713604015254 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 713604015255 FMN binding site [chemical binding]; other site 713604015256 dimer interface [polypeptide binding]; other site 713604015257 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 713604015258 dimer interface [polypeptide binding]; other site 713604015259 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015260 Ligand Binding Site [chemical binding]; other site 713604015261 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 713604015262 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 713604015263 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604015264 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 713604015265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604015266 motif II; other site 713604015267 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 713604015268 Acetokinase family; Region: Acetate_kinase; cl17229 713604015269 propionate/acetate kinase; Provisional; Region: PRK12379 713604015270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604015271 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604015272 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 713604015273 CoA binding domain; Region: CoA_binding_2; pfam13380 713604015274 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 713604015275 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 713604015276 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604015277 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604015278 Histidine kinase; Region: HisKA_3; pfam07730 713604015279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604015280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015281 ATP binding site [chemical binding]; other site 713604015282 Mg2+ binding site [ion binding]; other site 713604015283 G-X-G motif; other site 713604015284 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 713604015285 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015287 active site 713604015288 phosphorylation site [posttranslational modification] 713604015289 intermolecular recognition site; other site 713604015290 dimerization interface [polypeptide binding]; other site 713604015291 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015292 DNA binding residues [nucleotide binding] 713604015293 dimerization interface [polypeptide binding]; other site 713604015294 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 713604015295 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 713604015296 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 713604015297 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 713604015298 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 713604015299 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 713604015300 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 713604015301 Walker A/P-loop; other site 713604015302 ATP binding site [chemical binding]; other site 713604015303 Q-loop/lid; other site 713604015304 ABC transporter signature motif; other site 713604015305 Walker B; other site 713604015306 D-loop; other site 713604015307 H-loop/switch region; other site 713604015308 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 713604015309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604015310 Walker A/P-loop; other site 713604015311 ATP binding site [chemical binding]; other site 713604015312 Q-loop/lid; other site 713604015313 ABC transporter signature motif; other site 713604015314 Walker B; other site 713604015315 D-loop; other site 713604015316 H-loop/switch region; other site 713604015317 putative phosphoketolase; Provisional; Region: PRK05261 713604015318 XFP N-terminal domain; Region: XFP_N; pfam09364 713604015319 Src Homology 3 domain superfamily; Region: SH3; cl17036 713604015320 peptide ligand binding site [polypeptide binding]; other site 713604015321 XFP C-terminal domain; Region: XFP_C; pfam09363 713604015322 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015323 Ligand Binding Site [chemical binding]; other site 713604015324 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015325 Ligand Binding Site [chemical binding]; other site 713604015326 FOG: CBS domain [General function prediction only]; Region: COG0517 713604015327 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604015328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015329 Ligand Binding Site [chemical binding]; other site 713604015330 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015331 Ligand Binding Site [chemical binding]; other site 713604015332 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604015333 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015334 Ligand Binding Site [chemical binding]; other site 713604015335 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 713604015336 Ligand Binding Site [chemical binding]; other site 713604015337 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604015338 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604015339 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 713604015340 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 713604015341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604015342 Histidine kinase; Region: HisKA_3; pfam07730 713604015343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015344 ATP binding site [chemical binding]; other site 713604015345 Mg2+ binding site [ion binding]; other site 713604015346 G-X-G motif; other site 713604015347 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015349 active site 713604015350 phosphorylation site [posttranslational modification] 713604015351 intermolecular recognition site; other site 713604015352 dimerization interface [polypeptide binding]; other site 713604015353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015354 DNA binding residues [nucleotide binding] 713604015355 dimerization interface [polypeptide binding]; other site 713604015356 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604015357 GAF domain; Region: GAF; cl17456 713604015358 ANTAR domain; Region: ANTAR; pfam03861 713604015359 CAAX protease self-immunity; Region: Abi; pfam02517 713604015360 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604015361 Response regulator receiver domain; Region: Response_reg; pfam00072 713604015362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015363 active site 713604015364 phosphorylation site [posttranslational modification] 713604015365 intermolecular recognition site; other site 713604015366 dimerization interface [polypeptide binding]; other site 713604015367 Cupin domain; Region: Cupin_2; pfam07883 713604015368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015370 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604015371 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604015372 active site 713604015373 TDP-binding site; other site 713604015374 acceptor substrate-binding pocket; other site 713604015375 MarR family; Region: MarR; pfam01047 713604015376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604015377 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 713604015378 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604015379 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604015380 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 713604015381 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604015382 Histidine kinase; Region: HisKA_3; pfam07730 713604015383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015384 ATP binding site [chemical binding]; other site 713604015385 Mg2+ binding site [ion binding]; other site 713604015386 G-X-G motif; other site 713604015387 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015389 active site 713604015390 phosphorylation site [posttranslational modification] 713604015391 intermolecular recognition site; other site 713604015392 dimerization interface [polypeptide binding]; other site 713604015393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015394 DNA binding residues [nucleotide binding] 713604015395 dimerization interface [polypeptide binding]; other site 713604015396 Right handed beta helix region; Region: Beta_helix; pfam13229 713604015397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604015398 DNA-binding site [nucleotide binding]; DNA binding site 713604015399 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604015400 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 713604015401 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 713604015402 Catalytic site [active] 713604015403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015404 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604015405 catalytic core [active] 713604015406 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604015407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604015408 Transposase; Region: HTH_Tnp_1; cl17663 713604015409 putative transposase OrfB; Reviewed; Region: PHA02517 713604015410 HTH-like domain; Region: HTH_21; pfam13276 713604015411 Integrase core domain; Region: rve; pfam00665 713604015412 Integrase core domain; Region: rve_3; pfam13683 713604015413 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 713604015414 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604015415 RHS Repeat; Region: RHS_repeat; pfam05593 713604015416 RHS Repeat; Region: RHS_repeat; pfam05593 713604015417 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604015418 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 713604015419 protein-splicing catalytic site; other site 713604015420 thioester formation/cholesterol transfer; other site 713604015421 Pretoxin HINT domain; Region: PT-HINT; pfam07591 713604015422 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604015423 calcium mediated ligand binding site; other site 713604015424 intermolecular salt bridges; other site 713604015425 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604015426 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604015427 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604015428 Cytochrome P450; Region: p450; cl12078 713604015429 Fructosamine kinase; Region: Fructosamin_kin; cl17579 713604015430 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604015431 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604015432 active site 713604015433 metal binding site [ion binding]; metal-binding site 713604015434 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604015435 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604015436 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 713604015437 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604015438 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604015439 metal binding site [ion binding]; metal-binding site 713604015440 active site 713604015441 I-site; other site 713604015442 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604015443 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604015444 putative sugar binding sites [chemical binding]; other site 713604015445 Q-X-W motif; other site 713604015446 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 713604015447 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604015448 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 713604015449 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 713604015450 active site 713604015451 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604015452 dimer interface [polypeptide binding]; other site 713604015453 catalytic residues [active] 713604015454 substrate binding site [chemical binding]; other site 713604015455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604015456 Coenzyme A binding pocket [chemical binding]; other site 713604015457 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604015458 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604015459 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604015460 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604015461 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604015462 active site 713604015463 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604015464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604015465 active site 713604015466 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604015467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604015468 Walker A/P-loop; other site 713604015469 ATP binding site [chemical binding]; other site 713604015470 Q-loop/lid; other site 713604015471 ABC transporter signature motif; other site 713604015472 Walker B; other site 713604015473 D-loop; other site 713604015474 H-loop/switch region; other site 713604015475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604015476 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604015477 Walker A/P-loop; other site 713604015478 ATP binding site [chemical binding]; other site 713604015479 Q-loop/lid; other site 713604015480 ABC transporter signature motif; other site 713604015481 Walker B; other site 713604015482 D-loop; other site 713604015483 H-loop/switch region; other site 713604015484 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 713604015485 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604015486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604015487 S-adenosylmethionine binding site [chemical binding]; other site 713604015488 hypothetical protein; Provisional; Region: PRK07236 713604015489 FAD dependent oxidoreductase; Region: DAO; pfam01266 713604015490 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604015491 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604015492 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604015493 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 713604015494 Cytochrome P450; Region: p450; cl12078 713604015495 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604015496 Cytochrome P450; Region: p450; cl12078 713604015497 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 713604015498 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 713604015499 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604015500 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604015501 benzoate transport; Region: 2A0115; TIGR00895 713604015502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015503 putative substrate translocation pore; other site 713604015504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015505 putative substrate translocation pore; other site 713604015506 NB-ARC domain; Region: NB-ARC; pfam00931 713604015507 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604015508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604015509 binding surface 713604015510 TPR motif; other site 713604015511 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604015512 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604015513 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604015514 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 713604015515 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 713604015516 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 713604015517 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 713604015518 active site 713604015519 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 713604015520 MarR family; Region: MarR_2; pfam12802 713604015521 Predicted flavoprotein [General function prediction only]; Region: COG0431 713604015522 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604015523 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 713604015524 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604015525 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604015526 GAF domain; Region: GAF; pfam01590 713604015527 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604015528 hypothetical protein; Provisional; Region: PRK07877 713604015529 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015531 active site 713604015532 phosphorylation site [posttranslational modification] 713604015533 intermolecular recognition site; other site 713604015534 dimerization interface [polypeptide binding]; other site 713604015535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015536 dimerization interface [polypeptide binding]; other site 713604015537 DNA binding residues [nucleotide binding] 713604015538 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 713604015539 BON domain; Region: BON; pfam04972 713604015540 BON domain; Region: BON; pfam04972 713604015541 BON domain; Region: BON; pfam04972 713604015542 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 713604015543 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 713604015544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604015545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 713604015546 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604015547 GAF domain; Region: GAF_3; pfam13492 713604015548 ANTAR domain; Region: ANTAR; cl04297 713604015549 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604015550 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604015551 Di-iron ligands [ion binding]; other site 713604015552 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 713604015553 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 713604015554 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604015555 anti sigma factor interaction site; other site 713604015556 regulatory phosphorylation site [posttranslational modification]; other site 713604015557 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604015558 XFP C-terminal domain; Region: XFP_C; pfam09363 713604015559 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 713604015560 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604015561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015562 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604015563 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604015564 putative sugar binding sites [chemical binding]; other site 713604015565 Q-X-W motif; other site 713604015566 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604015567 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604015568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015569 active site 713604015570 phosphorylation site [posttranslational modification] 713604015571 intermolecular recognition site; other site 713604015572 dimerization interface [polypeptide binding]; other site 713604015573 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604015574 DNA binding site [nucleotide binding] 713604015575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604015576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604015577 dimerization interface [polypeptide binding]; other site 713604015578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604015579 dimer interface [polypeptide binding]; other site 713604015580 phosphorylation site [posttranslational modification] 713604015581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015582 ATP binding site [chemical binding]; other site 713604015583 Mg2+ binding site [ion binding]; other site 713604015584 G-X-G motif; other site 713604015585 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604015586 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 713604015587 putative ADP-binding pocket [chemical binding]; other site 713604015588 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 713604015589 AAA ATPase domain; Region: AAA_16; pfam13191 713604015590 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 713604015591 short chain dehydrogenase; Provisional; Region: PRK06523 713604015592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015593 NAD(P) binding site [chemical binding]; other site 713604015594 active site 713604015595 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015596 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015597 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604015598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604015599 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604015600 dimerization interface [polypeptide binding]; other site 713604015601 putative DNA binding site [nucleotide binding]; other site 713604015602 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 713604015603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604015604 motif II; other site 713604015605 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604015606 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604015607 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604015608 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604015609 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604015610 putative sugar binding sites [chemical binding]; other site 713604015611 Q-X-W motif; other site 713604015612 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604015613 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604015614 dimerization interface [polypeptide binding]; other site 713604015615 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 713604015616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015617 NAD(P) binding site [chemical binding]; other site 713604015618 active site 713604015619 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 713604015620 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 713604015621 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604015622 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015623 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604015624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015625 NAD(P) binding site [chemical binding]; other site 713604015626 active site 713604015627 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604015628 active site 713604015629 substrate binding site [chemical binding]; other site 713604015630 ATP binding site [chemical binding]; other site 713604015631 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604015632 activation loop (A-loop); other site 713604015633 CBD_II domain; Region: CBD_II; smart00637 713604015634 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 713604015635 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604015636 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604015637 DNA binding residues [nucleotide binding] 713604015638 Leucine carboxyl methyltransferase; Region: LCM; cl01306 713604015639 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604015640 Cytochrome P450; Region: p450; cl12078 713604015641 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 713604015642 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604015643 Cytochrome P450; Region: p450; cl12078 713604015644 hypothetical protein; Provisional; Region: PRK06834 713604015645 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604015646 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604015647 MarR family; Region: MarR_2; pfam12802 713604015648 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604015649 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604015650 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604015651 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604015652 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 713604015653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604015654 active site 713604015655 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604015656 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604015657 AAA ATPase domain; Region: AAA_16; pfam13191 713604015658 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015659 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015660 DNA binding residues [nucleotide binding] 713604015661 dimerization interface [polypeptide binding]; other site 713604015662 AAA ATPase domain; Region: AAA_16; pfam13191 713604015663 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015664 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015665 DNA binding residues [nucleotide binding] 713604015666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015667 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 713604015668 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 713604015669 putative heme binding pocket [chemical binding]; other site 713604015670 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015671 short chain dehydrogenase; Provisional; Region: PRK07041 713604015672 NAD(P) binding site [chemical binding]; other site 713604015673 active site 713604015674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015675 putative substrate translocation pore; other site 713604015676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604015679 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015680 dimerization interface [polypeptide binding]; other site 713604015681 DNA binding residues [nucleotide binding] 713604015682 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 713604015683 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 713604015684 putative active site [active] 713604015685 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 713604015686 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 713604015687 Walker A/P-loop; other site 713604015688 ATP binding site [chemical binding]; other site 713604015689 Q-loop/lid; other site 713604015690 ABC transporter signature motif; other site 713604015691 Walker B; other site 713604015692 D-loop; other site 713604015693 H-loop/switch region; other site 713604015694 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 713604015695 active site 713604015696 catalytic site [active] 713604015697 PBP superfamily domain; Region: PBP_like_2; cl17296 713604015698 PBP superfamily domain; Region: PBP_like_2; cl17296 713604015699 PBP superfamily domain; Region: PBP_like_2; cl17296 713604015700 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 713604015701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604015702 dimer interface [polypeptide binding]; other site 713604015703 conserved gate region; other site 713604015704 putative PBP binding loops; other site 713604015705 ABC-ATPase subunit interface; other site 713604015706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604015707 dimer interface [polypeptide binding]; other site 713604015708 conserved gate region; other site 713604015709 putative PBP binding loops; other site 713604015710 ABC-ATPase subunit interface; other site 713604015711 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604015712 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 713604015713 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604015714 dimerization interface [polypeptide binding]; other site 713604015715 ligand binding site [chemical binding]; other site 713604015716 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604015717 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604015718 dimerization interface [polypeptide binding]; other site 713604015719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604015720 dimer interface [polypeptide binding]; other site 713604015721 phosphorylation site [posttranslational modification] 713604015722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015723 ATP binding site [chemical binding]; other site 713604015724 Mg2+ binding site [ion binding]; other site 713604015725 G-X-G motif; other site 713604015726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604015727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015728 active site 713604015729 phosphorylation site [posttranslational modification] 713604015730 intermolecular recognition site; other site 713604015731 dimerization interface [polypeptide binding]; other site 713604015732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604015733 DNA binding site [nucleotide binding] 713604015734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604015735 active site 713604015736 Predicted membrane protein [Function unknown]; Region: COG2246 713604015737 GtrA-like protein; Region: GtrA; pfam04138 713604015738 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 713604015739 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604015740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015742 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604015743 putative substrate translocation pore; other site 713604015744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604015745 hypothetical protein; Provisional; Region: PRK07588 713604015746 hypothetical protein; Provisional; Region: PRK07236 713604015747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015749 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604015750 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604015751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015755 DDE superfamily endonuclease; Region: DDE_5; cl17874 713604015756 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604015757 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604015758 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015760 WHG domain; Region: WHG; pfam13305 713604015761 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 713604015762 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604015763 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604015764 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604015765 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 713604015766 DDE superfamily endonuclease; Region: DDE_5; cl17874 713604015767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 713604015768 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604015769 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604015770 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604015771 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604015772 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604015773 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 713604015774 catalytic triad [active] 713604015775 conserved cis-peptide bond; other site 713604015776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015777 NAD(P) binding site [chemical binding]; other site 713604015778 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604015779 Uncharacterized conserved protein [Function unknown]; Region: COG1359 713604015780 hypothetical protein; Provisional; Region: PRK08244 713604015781 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604015782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015784 Cupin domain; Region: Cupin_2; pfam07883 713604015785 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604015786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604015787 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604015788 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604015789 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604015790 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 713604015791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015792 NAD(P) binding site [chemical binding]; other site 713604015793 active site 713604015794 Cupin domain; Region: Cupin_2; pfam07883 713604015795 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604015796 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604015797 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 713604015798 active site 713604015799 metal binding site [ion binding]; metal-binding site 713604015800 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604015801 DNA-binding site [nucleotide binding]; DNA binding site 713604015802 RNA-binding motif; other site 713604015803 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604015804 DNA-binding site [nucleotide binding]; DNA binding site 713604015805 RNA-binding motif; other site 713604015806 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604015807 DNA-binding site [nucleotide binding]; DNA binding site 713604015808 RNA-binding motif; other site 713604015809 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604015810 DNA-binding site [nucleotide binding]; DNA binding site 713604015811 RNA-binding motif; other site 713604015812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015814 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 713604015815 putative hydrophobic ligand binding site [chemical binding]; other site 713604015816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604015817 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 713604015818 NAD(P) binding site [chemical binding]; other site 713604015819 active site 713604015820 YCII-related domain; Region: YCII; cl00999 713604015821 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604015822 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604015823 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604015824 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 713604015825 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604015826 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 713604015827 potassium/proton antiporter; Reviewed; Region: PRK05326 713604015828 TrkA-C domain; Region: TrkA_C; pfam02080 713604015829 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 713604015830 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 713604015831 D-pathway; other site 713604015832 Putative ubiquinol binding site [chemical binding]; other site 713604015833 Low-spin heme (heme b) binding site [chemical binding]; other site 713604015834 Putative water exit pathway; other site 713604015835 Binuclear center (heme o3/CuB) [ion binding]; other site 713604015836 K-pathway; other site 713604015837 Putative proton exit pathway; other site 713604015838 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 713604015839 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 713604015840 iron-sulfur cluster [ion binding]; other site 713604015841 [2Fe-2S] cluster binding site [ion binding]; other site 713604015842 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 713604015843 heme bH binding site [chemical binding]; other site 713604015844 Qi binding site; other site 713604015845 intrachain domain interface; other site 713604015846 heme bL binding site [chemical binding]; other site 713604015847 interchain domain interface [polypeptide binding]; other site 713604015848 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 713604015849 Qo binding site; other site 713604015850 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 713604015851 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604015852 hypothetical protein; Provisional; Region: PRK07588 713604015853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604015854 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604015855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604015856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604015857 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604015858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604015859 active site 713604015860 phosphorylation site [posttranslational modification] 713604015861 intermolecular recognition site; other site 713604015862 dimerization interface [polypeptide binding]; other site 713604015863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604015864 DNA binding site [nucleotide binding] 713604015865 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604015866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604015867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604015868 dimer interface [polypeptide binding]; other site 713604015869 phosphorylation site [posttranslational modification] 713604015870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604015871 ATP binding site [chemical binding]; other site 713604015872 Mg2+ binding site [ion binding]; other site 713604015873 G-X-G motif; other site 713604015874 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604015875 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604015876 dimerization interface [polypeptide binding]; other site 713604015877 putative DNA binding site [nucleotide binding]; other site 713604015878 putative Zn2+ binding site [ion binding]; other site 713604015879 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 713604015880 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604015881 MarR family; Region: MarR; pfam01047 713604015882 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 713604015883 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 713604015884 Cl- selectivity filter; other site 713604015885 Cl- binding residues [ion binding]; other site 713604015886 pore gating glutamate residue; other site 713604015887 dimer interface [polypeptide binding]; other site 713604015888 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 713604015889 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604015890 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 713604015891 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 713604015892 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 713604015893 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604015894 molybdopterin cofactor binding site; other site 713604015895 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604015896 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604015897 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 713604015898 molybdopterin cofactor binding site; other site 713604015899 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 713604015900 4Fe-4S binding domain; Region: Fer4; pfam00037 713604015901 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 713604015902 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 713604015903 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604015904 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604015905 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604015906 active site 713604015907 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 713604015908 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 713604015909 membrane-bound complex binding site; other site 713604015910 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 713604015911 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 713604015912 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 713604015913 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 713604015914 transmembrane helices; other site 713604015915 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604015916 potassium/proton antiporter; Reviewed; Region: PRK05326 713604015917 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604015918 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 713604015919 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 713604015920 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 713604015921 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 713604015922 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 713604015923 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604015924 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 713604015925 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604015926 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604015927 active site 713604015928 catalytic tetrad [active] 713604015929 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 713604015930 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604015931 catalytic Zn binding site [ion binding]; other site 713604015932 NAD(P) binding site [chemical binding]; other site 713604015933 structural Zn binding site [ion binding]; other site 713604015934 short chain dehydrogenase; Provisional; Region: PRK06180 713604015935 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604015936 NADP binding site [chemical binding]; other site 713604015937 active site 713604015938 steroid binding site; other site 713604015939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604015940 salt bridge; other site 713604015941 non-specific DNA binding site [nucleotide binding]; other site 713604015942 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604015943 sequence-specific DNA binding site [nucleotide binding]; other site 713604015944 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604015945 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604015946 active site 713604015947 catalytic tetrad [active] 713604015948 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 713604015949 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 713604015950 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604015951 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604015952 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604015953 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604015954 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604015955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604015956 dimer interface [polypeptide binding]; other site 713604015957 conserved gate region; other site 713604015958 putative PBP binding loops; other site 713604015959 ABC-ATPase subunit interface; other site 713604015960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604015961 conserved gate region; other site 713604015962 dimer interface [polypeptide binding]; other site 713604015963 putative PBP binding loops; other site 713604015964 ABC-ATPase subunit interface; other site 713604015965 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604015966 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604015967 DNA binding site [nucleotide binding] 713604015968 domain linker motif; other site 713604015969 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604015970 dimerization interface [polypeptide binding]; other site 713604015971 ligand binding site [chemical binding]; other site 713604015972 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 713604015973 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604015974 dimerization interface [polypeptide binding]; other site 713604015975 ligand binding site [chemical binding]; other site 713604015976 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604015977 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604015978 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 713604015979 DNA binding residues [nucleotide binding] 713604015980 dimerization interface [polypeptide binding]; other site 713604015981 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604015982 DNA binding site [nucleotide binding] 713604015983 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604015984 domain linker motif; other site 713604015985 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604015986 dimerization interface [polypeptide binding]; other site 713604015987 ligand binding site [chemical binding]; other site 713604015988 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 713604015989 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604015990 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604015991 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604015992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604015993 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 713604015994 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 713604015995 DDE superfamily endonuclease; Region: DDE_5; cl17874 713604015996 Predicted ATPase [General function prediction only]; Region: COG3903 713604015997 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 713604015998 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 713604015999 ligand binding site [chemical binding]; other site 713604016000 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604016001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604016002 TPR motif; other site 713604016003 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 713604016004 active site 713604016005 iron coordination sites [ion binding]; other site 713604016006 substrate binding pocket [chemical binding]; other site 713604016007 CHAT domain; Region: CHAT; cl17868 713604016008 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604016009 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 713604016010 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 713604016011 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 713604016012 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 713604016013 DDE superfamily endonuclease; Region: DDE_5; cl17874 713604016014 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 713604016015 Restriction endonuclease; Region: Mrr_cat; pfam04471 713604016016 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 713604016017 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 713604016018 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 713604016019 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 713604016020 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 713604016021 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 713604016022 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 713604016023 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 713604016024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 713604016025 putative transposase OrfB; Reviewed; Region: PHA02517 713604016026 HTH-like domain; Region: HTH_21; pfam13276 713604016027 Integrase core domain; Region: rve; pfam00665 713604016028 Integrase core domain; Region: rve_3; pfam13683 713604016029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604016030 Transposase; Region: HTH_Tnp_1; cl17663 713604016031 Integrase core domain; Region: rve; pfam00665 713604016032 Integrase core domain; Region: rve_3; pfam13683 713604016033 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604016034 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 713604016035 structural tetrad; other site 713604016036 FOG: WD40 repeat [General function prediction only]; Region: COG2319 713604016037 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 713604016038 structural tetrad; other site 713604016039 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 713604016040 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 713604016041 catalytic residues [active] 713604016042 catalytic nucleophile [active] 713604016043 Recombinase; Region: Recombinase; pfam07508 713604016044 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 713604016045 Cellulose binding domain; Region: CBM_2; pfam00553 713604016046 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 713604016047 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 713604016048 putative dimer interface [polypeptide binding]; other site 713604016049 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604016050 amidase; Provisional; Region: PRK06170 713604016051 Amidase; Region: Amidase; cl11426 713604016052 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 713604016053 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604016054 DNA binding residues [nucleotide binding] 713604016055 drug binding residues [chemical binding]; other site 713604016056 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 713604016057 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604016058 dimerization interface [polypeptide binding]; other site 713604016059 putative DNA binding site [nucleotide binding]; other site 713604016060 putative Zn2+ binding site [ion binding]; other site 713604016061 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 713604016062 Cation efflux family; Region: Cation_efflux; cl00316 713604016063 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 713604016064 Leucine-rich repeats; other site 713604016065 Substrate binding site [chemical binding]; other site 713604016066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604016067 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604016068 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 713604016069 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604016070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604016071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604016072 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604016073 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604016074 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 713604016075 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604016076 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604016077 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 713604016078 metal ion-dependent adhesion site (MIDAS); other site 713604016079 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 713604016080 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604016081 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604016082 active site 713604016083 ATP binding site [chemical binding]; other site 713604016084 substrate binding site [chemical binding]; other site 713604016085 activation loop (A-loop); other site 713604016086 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604016087 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 713604016088 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604016089 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604016090 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604016091 Walker A/P-loop; other site 713604016092 ATP binding site [chemical binding]; other site 713604016093 Q-loop/lid; other site 713604016094 ABC transporter signature motif; other site 713604016095 Walker B; other site 713604016096 D-loop; other site 713604016097 H-loop/switch region; other site 713604016098 Predicted transcriptional regulators [Transcription]; Region: COG1725 713604016099 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604016100 DNA-binding site [nucleotide binding]; DNA binding site 713604016101 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 713604016102 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 713604016103 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604016104 dimer interface [polypeptide binding]; other site 713604016105 PYR/PP interface [polypeptide binding]; other site 713604016106 TPP binding site [chemical binding]; other site 713604016107 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604016108 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 713604016109 TPP-binding site [chemical binding]; other site 713604016110 Domain of unknown function (DUF222); Region: DUF222; pfam02720 713604016111 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604016112 active site 713604016113 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604016114 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604016115 putative DNA binding site [nucleotide binding]; other site 713604016116 putative Zn2+ binding site [ion binding]; other site 713604016117 AsnC family; Region: AsnC_trans_reg; pfam01037 713604016118 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 713604016119 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 713604016120 dimer interface [polypeptide binding]; other site 713604016121 PYR/PP interface [polypeptide binding]; other site 713604016122 TPP binding site [chemical binding]; other site 713604016123 substrate binding site [chemical binding]; other site 713604016124 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 713604016125 TPP-binding site; other site 713604016126 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 713604016127 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604016128 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 713604016129 DNA binding residues [nucleotide binding] 713604016130 dimerization interface [polypeptide binding]; other site 713604016131 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 713604016132 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604016133 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 713604016134 CAAX protease self-immunity; Region: Abi; cl00558 713604016135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604016136 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604016137 NAD(P) binding site [chemical binding]; other site 713604016138 active site 713604016139 EamA-like transporter family; Region: EamA; pfam00892 713604016140 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604016141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604016142 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604016143 putative dimerization interface [polypeptide binding]; other site 713604016144 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604016145 dimerization interface [polypeptide binding]; other site 713604016146 threonine dehydratase; Provisional; Region: PRK08246 713604016147 hypothetical protein; Provisional; Region: PRK06815 713604016148 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604016149 catalytic residue [active] 713604016150 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604016151 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604016152 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604016153 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604016154 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604016155 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 713604016156 transcription termination factor Rho; Provisional; Region: PRK12608 713604016157 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 713604016158 RNA binding site [nucleotide binding]; other site 713604016159 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604016160 Walker A motif; other site 713604016161 ATP binding site [chemical binding]; other site 713604016162 Walker B motif; other site 713604016163 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604016164 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 713604016165 Mg2+ binding site [ion binding]; other site 713604016166 G-X-G motif; other site 713604016167 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 713604016168 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604016169 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604016170 Cellulose binding domain; Region: CBM_2; cl17741 713604016171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604016172 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604016173 salt bridge; other site 713604016174 non-specific DNA binding site [nucleotide binding]; other site 713604016175 sequence-specific DNA binding site [nucleotide binding]; other site 713604016176 short chain dehydrogenase; Provisional; Region: PRK06180 713604016177 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604016178 NADP binding site [chemical binding]; other site 713604016179 active site 713604016180 steroid binding site; other site 713604016181 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604016182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604016183 NAD(P) binding site [chemical binding]; other site 713604016184 active site 713604016185 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 713604016186 putative substrate binding site [chemical binding]; other site 713604016187 putative ATP binding site [chemical binding]; other site 713604016188 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604016189 catalytic core [active] 713604016190 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604016191 GAF domain; Region: GAF; pfam01590 713604016192 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604016193 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604016194 anti sigma factor interaction site; other site 713604016195 regulatory phosphorylation site [posttranslational modification]; other site 713604016196 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604016197 anti sigma factor interaction site; other site 713604016198 regulatory phosphorylation site [posttranslational modification]; other site 713604016199 GAF domain; Region: GAF; pfam01590 713604016200 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604016201 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 713604016202 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604016203 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604016204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604016205 Mg2+ binding site [ion binding]; other site 713604016206 PAS fold; Region: PAS_4; pfam08448 713604016207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604016208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604016209 dimer interface [polypeptide binding]; other site 713604016210 phosphorylation site [posttranslational modification] 713604016211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604016212 ATP binding site [chemical binding]; other site 713604016213 Mg2+ binding site [ion binding]; other site 713604016214 G-X-G motif; other site 713604016215 Response regulator receiver domain; Region: Response_reg; pfam00072 713604016216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604016217 active site 713604016218 phosphorylation site [posttranslational modification] 713604016219 intermolecular recognition site; other site 713604016220 dimerization interface [polypeptide binding]; other site 713604016221 PAS domain; Region: PAS_9; pfam13426 713604016222 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604016223 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604016224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604016225 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604016226 anti sigma factor interaction site; other site 713604016227 regulatory phosphorylation site [posttranslational modification]; other site 713604016228 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604016229 GAF domain; Region: GAF; pfam01590 713604016230 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 713604016231 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604016232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604016233 ATP binding site [chemical binding]; other site 713604016234 Mg2+ binding site [ion binding]; other site 713604016235 G-X-G motif; other site 713604016236 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 713604016237 Domain interface; other site 713604016238 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 713604016239 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604016240 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 713604016241 putative ligand binding site [chemical binding]; other site 713604016242 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604016243 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604016244 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604016245 active site 713604016246 catalytic tetrad [active] 713604016247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604016248 short chain dehydrogenase; Provisional; Region: PRK05854 713604016249 NAD(P) binding site [chemical binding]; other site 713604016250 active site 713604016251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604016252 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604016253 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604016254 DNA binding site [nucleotide binding] 713604016255 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604016256 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604016257 AAA domain; Region: AAA_22; pfam13401 713604016258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604016259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604016260 TPR motif; other site 713604016261 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604016262 binding surface 713604016263 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604016264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604016265 non-specific DNA binding site [nucleotide binding]; other site 713604016266 salt bridge; other site 713604016267 sequence-specific DNA binding site [nucleotide binding]; other site 713604016268 Flavoprotein; Region: Flavoprotein; pfam02441 713604016269 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604016270 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604016271 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 713604016272 active site 713604016273 catalytic residues [active] 713604016274 DNA binding site [nucleotide binding] 713604016275 Int/Topo IB signature motif; other site 713604016276 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 713604016277 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 713604016278 NAD(P) binding site [chemical binding]; other site 713604016279 catalytic residues [active] 713604016280 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604016281 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 713604016282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604016283 non-specific DNA binding site [nucleotide binding]; other site 713604016284 salt bridge; other site 713604016285 sequence-specific DNA binding site [nucleotide binding]; other site 713604016286 Biofilm formation and stress response factor; Region: BsmA; cl01794 713604016287 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604016288 anti sigma factor interaction site; other site 713604016289 regulatory phosphorylation site [posttranslational modification]; other site 713604016290 methionine sulfoxide reductase A; Provisional; Region: PRK14054 713604016291 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 713604016292 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 713604016293 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 713604016294 active site 713604016295 Zn binding site [ion binding]; other site 713604016296 OsmC-like protein; Region: OsmC; pfam02566 713604016297 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604016298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604016299 Walker A/P-loop; other site 713604016300 ATP binding site [chemical binding]; other site 713604016301 Q-loop/lid; other site 713604016302 ABC transporter signature motif; other site 713604016303 Walker B; other site 713604016304 D-loop; other site 713604016305 H-loop/switch region; other site 713604016306 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604016307 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604016308 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604016309 oxidoreductase; Provisional; Region: PRK06196 713604016310 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 713604016311 putative NAD(P) binding site [chemical binding]; other site 713604016312 active site 713604016313 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604016314 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604016315 active site 713604016316 ATP binding site [chemical binding]; other site 713604016317 substrate binding site [chemical binding]; other site 713604016318 activation loop (A-loop); other site 713604016319 YCII-related domain; Region: YCII; cl00999 713604016320 NAD-dependent deacetylase; Provisional; Region: PRK00481 713604016321 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 713604016322 NAD+ binding site [chemical binding]; other site 713604016323 substrate binding site [chemical binding]; other site 713604016324 Zn binding site [ion binding]; other site 713604016325 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 713604016326 ApbE family; Region: ApbE; pfam02424 713604016327 ApbE family; Region: ApbE; pfam02424 713604016328 Phosphoesterase family; Region: Phosphoesterase; pfam04185 713604016329 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604016330 Tannase and feruloyl esterase; Region: Tannase; pfam07519 713604016331 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 713604016332 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604016333 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 713604016334 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 713604016335 YcaO-like family; Region: YcaO; pfam02624 713604016336 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604016337 GAF domain; Region: GAF; pfam01590 713604016338 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604016339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604016340 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604016341 putative substrate translocation pore; other site 713604016342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604016343 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 713604016344 NAD(P) binding site [chemical binding]; other site 713604016345 active site 713604016346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604016347 sequence-specific DNA binding site [nucleotide binding]; other site 713604016348 salt bridge; other site 713604016349 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604016350 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604016351 active site 713604016352 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604016353 HTH domain; Region: HTH_11; pfam08279 713604016354 WYL domain; Region: WYL; pfam13280 713604016355 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604016356 hydrophobic ligand binding site; other site 713604016357 acyl-CoA synthetase; Validated; Region: PRK07788 713604016358 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604016359 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604016360 acyl-activating enzyme (AAE) consensus motif; other site 713604016361 acyl-activating enzyme (AAE) consensus motif; other site 713604016362 AMP binding site [chemical binding]; other site 713604016363 active site 713604016364 CoA binding site [chemical binding]; other site 713604016365 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 713604016366 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604016367 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604016368 MoxR-like ATPases [General function prediction only]; Region: COG0714 713604016369 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 713604016370 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 713604016371 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604016372 metal ion-dependent adhesion site (MIDAS); other site 713604016373 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 713604016374 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604016375 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604016376 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604016377 SCP-2 sterol transfer family; Region: SCP2; pfam02036 713604016378 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604016379 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604016380 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 713604016381 substrate binding site [chemical binding]; other site 713604016382 catalytic residues [active] 713604016383 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 713604016384 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 713604016385 dimer interface [polypeptide binding]; other site 713604016386 NADP binding site [chemical binding]; other site 713604016387 catalytic residues [active] 713604016388 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 713604016389 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 713604016390 active site 713604016391 tetramer interface [polypeptide binding]; other site 713604016392 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 713604016393 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 713604016394 catalytic residue [active] 713604016395 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 713604016396 Na binding site [ion binding]; other site 713604016397 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604016398 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604016399 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604016400 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604016401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604016402 NAD(P) binding site [chemical binding]; other site 713604016403 active site 713604016404 Clp amino terminal domain; Region: Clp_N; pfam02861 713604016405 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 713604016406 DNA-binding interface [nucleotide binding]; DNA binding site 713604016407 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 713604016408 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 713604016409 NodB motif; other site 713604016410 putative active site [active] 713604016411 putative catalytic site [active] 713604016412 putative Zn binding site [ion binding]; other site 713604016413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604016414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604016415 active site 713604016416 phosphorylation site [posttranslational modification] 713604016417 intermolecular recognition site; other site 713604016418 dimerization interface [polypeptide binding]; other site 713604016419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604016420 DNA binding residues [nucleotide binding] 713604016421 dimerization interface [polypeptide binding]; other site 713604016422 Phosphotransferase enzyme family; Region: APH; pfam01636 713604016423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604016424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604016425 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604016426 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 713604016427 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 713604016428 FMN-binding pocket [chemical binding]; other site 713604016429 flavin binding motif; other site 713604016430 phosphate binding motif [ion binding]; other site 713604016431 beta-alpha-beta structure motif; other site 713604016432 NAD binding pocket [chemical binding]; other site 713604016433 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604016434 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 713604016435 catalytic loop [active] 713604016436 iron binding site [ion binding]; other site 713604016437 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 713604016438 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 713604016439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604016440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604016441 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 713604016442 active site 713604016443 dimer interface [polypeptide binding]; other site 713604016444 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 713604016445 metal binding site [ion binding]; metal-binding site 713604016446 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 713604016447 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 713604016448 active site 713604016449 FAD binding domain; Region: FAD_binding_3; pfam01494 713604016450 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604016451 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 713604016452 active site 713604016453 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 713604016454 Zn binding site [ion binding]; other site 713604016455 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604016456 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604016457 acyl-activating enzyme (AAE) consensus motif; other site 713604016458 AMP binding site [chemical binding]; other site 713604016459 active site 713604016460 CoA binding site [chemical binding]; other site 713604016461 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604016462 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 713604016463 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604016464 putative trimer interface [polypeptide binding]; other site 713604016465 putative CoA binding site [chemical binding]; other site 713604016466 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 713604016467 putative trimer interface [polypeptide binding]; other site 713604016468 putative CoA binding site [chemical binding]; other site 713604016469 GTP-binding protein Der; Reviewed; Region: PRK03003 713604016470 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 713604016471 G1 box; other site 713604016472 GTP/Mg2+ binding site [chemical binding]; other site 713604016473 Switch I region; other site 713604016474 G2 box; other site 713604016475 Switch II region; other site 713604016476 G3 box; other site 713604016477 G4 box; other site 713604016478 G5 box; other site 713604016479 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 713604016480 G1 box; other site 713604016481 GTP/Mg2+ binding site [chemical binding]; other site 713604016482 Switch I region; other site 713604016483 G2 box; other site 713604016484 G3 box; other site 713604016485 Switch II region; other site 713604016486 G4 box; other site 713604016487 G5 box; other site 713604016488 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604016489 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604016490 putative acyl-acceptor binding pocket; other site 713604016491 cytidylate kinase; Provisional; Region: cmk; PRK00023 713604016492 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 713604016493 CMP-binding site; other site 713604016494 The sites determining sugar specificity; other site 713604016495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604016496 WHG domain; Region: WHG; pfam13305 713604016497 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 713604016498 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 713604016499 TrkA-C domain; Region: TrkA_C; pfam02080 713604016500 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 713604016501 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 713604016502 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 713604016503 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604016504 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 713604016505 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 713604016506 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713604016507 RNA binding surface [nucleotide binding]; other site 713604016508 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 713604016509 active site 713604016510 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 713604016511 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 713604016512 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 713604016513 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604016514 P-loop; other site 713604016515 Magnesium ion binding site [ion binding]; other site 713604016516 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604016517 Magnesium ion binding site [ion binding]; other site 713604016518 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 713604016519 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604016520 active site 713604016521 DNA binding site [nucleotide binding] 713604016522 Int/Topo IB signature motif; other site 713604016523 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604016524 TM2 domain; Region: TM2; pfam05154 713604016525 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 713604016526 dimer interface [polypeptide binding]; other site 713604016527 ADP-ribose binding site [chemical binding]; other site 713604016528 active site 713604016529 nudix motif; other site 713604016530 metal binding site [ion binding]; metal-binding site 713604016531 CTP synthetase; Validated; Region: pyrG; PRK05380 713604016532 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 713604016533 active site 713604016534 UTP binding site [chemical binding]; other site 713604016535 Catalytic site [active] 713604016536 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 713604016537 active site 713604016538 putative oxyanion hole; other site 713604016539 catalytic triad [active] 713604016540 Acyltransferase family; Region: Acyl_transf_3; pfam01757 713604016541 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604016542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604016543 DNA-binding site [nucleotide binding]; DNA binding site 713604016544 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604016545 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 713604016546 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 713604016547 Na binding site [ion binding]; other site 713604016548 putative substrate binding site [chemical binding]; other site 713604016549 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 713604016550 Alginate lyase; Region: Alginate_lyase; pfam05426 713604016551 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 713604016552 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 713604016553 Thiamine pyrophosphokinase; Region: TPK; cl08415 713604016554 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 713604016555 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 713604016556 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 713604016557 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604016558 putative NAD(P) binding site [chemical binding]; other site 713604016559 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604016560 MarR family; Region: MarR_2; pfam12802 713604016561 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 713604016562 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 713604016563 Walker A/P-loop; other site 713604016564 ATP binding site [chemical binding]; other site 713604016565 Q-loop/lid; other site 713604016566 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 713604016567 ABC transporter signature motif; other site 713604016568 Walker B; other site 713604016569 D-loop; other site 713604016570 H-loop/switch region; other site 713604016571 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 713604016572 ATP-NAD kinase; Region: NAD_kinase; pfam01513 713604016573 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 713604016574 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713604016575 RNA binding surface [nucleotide binding]; other site 713604016576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604016577 S-adenosylmethionine binding site [chemical binding]; other site 713604016578 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 713604016579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604016580 active site 713604016581 motif I; other site 713604016582 motif II; other site 713604016583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604016584 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 713604016585 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 713604016586 active site 713604016587 HIGH motif; other site 713604016588 dimer interface [polypeptide binding]; other site 713604016589 KMSKS motif; other site 713604016590 S4 RNA-binding domain; Region: S4; smart00363 713604016591 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 713604016592 active site 713604016593 DNA binding site [nucleotide binding] 713604016594 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 713604016595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 713604016596 argininosuccinate lyase; Provisional; Region: PRK00855 713604016597 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 713604016598 active sites [active] 713604016599 tetramer interface [polypeptide binding]; other site 713604016600 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 713604016601 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 713604016602 arginine repressor; Provisional; Region: PRK03341 713604016603 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 713604016604 ornithine carbamoyltransferase; Provisional; Region: PRK00779 713604016605 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 713604016606 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 713604016607 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 713604016608 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604016609 inhibitor-cofactor binding pocket; inhibition site 713604016610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604016611 catalytic residue [active] 713604016612 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 713604016613 feedback inhibition sensing region; other site 713604016614 homohexameric interface [polypeptide binding]; other site 713604016615 nucleotide binding site [chemical binding]; other site 713604016616 N-acetyl-L-glutamate binding site [chemical binding]; other site 713604016617 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 713604016618 heterotetramer interface [polypeptide binding]; other site 713604016619 active site pocket [active] 713604016620 cleavage site 713604016621 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 713604016622 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 713604016623 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604016624 HTH domain; Region: HTH_11; pfam08279 713604016625 WYL domain; Region: WYL; pfam13280 713604016626 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604016627 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604016628 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 713604016629 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 713604016630 active site 713604016631 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 713604016632 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 713604016633 putative tRNA-binding site [nucleotide binding]; other site 713604016634 B3/4 domain; Region: B3_4; pfam03483 713604016635 tRNA synthetase B5 domain; Region: B5; smart00874 713604016636 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 713604016637 dimer interface [polypeptide binding]; other site 713604016638 motif 1; other site 713604016639 motif 3; other site 713604016640 motif 2; other site 713604016641 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 713604016642 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 713604016643 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 713604016644 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 713604016645 dimer interface [polypeptide binding]; other site 713604016646 motif 1; other site 713604016647 active site 713604016648 motif 2; other site 713604016649 motif 3; other site 713604016650 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 713604016651 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 713604016652 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 713604016653 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 713604016654 23S rRNA binding site [nucleotide binding]; other site 713604016655 L21 binding site [polypeptide binding]; other site 713604016656 L13 binding site [polypeptide binding]; other site 713604016657 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 713604016658 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 713604016659 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 713604016660 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 713604016661 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604016662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604016663 DNA-binding site [nucleotide binding]; DNA binding site 713604016664 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 713604016665 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 713604016666 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604016667 catalytic residue [active] 713604016668 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 713604016669 homotrimer interaction site [polypeptide binding]; other site 713604016670 putative active site [active] 713604016671 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604016672 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 713604016673 DNA binding site [nucleotide binding] 713604016674 sequence specific DNA binding site [nucleotide binding]; other site 713604016675 putative cAMP binding site [chemical binding]; other site 713604016676 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604016677 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 713604016678 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604016679 substrate binding site [chemical binding]; other site 713604016680 ATP binding site [chemical binding]; other site 713604016681 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 713604016682 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 713604016683 active site 713604016684 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604016685 dimer interface [polypeptide binding]; other site 713604016686 substrate binding site [chemical binding]; other site 713604016687 catalytic residue [active] 713604016688 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 713604016689 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 713604016690 active site 713604016691 putative substrate binding pocket [chemical binding]; other site 713604016692 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604016693 fructuronate transporter; Provisional; Region: PRK10034; cl15264 713604016694 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 713604016695 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604016696 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604016697 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 713604016698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604016699 dimer interface [polypeptide binding]; other site 713604016700 conserved gate region; other site 713604016701 putative PBP binding loops; other site 713604016702 ABC-ATPase subunit interface; other site 713604016703 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604016704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604016705 dimer interface [polypeptide binding]; other site 713604016706 conserved gate region; other site 713604016707 putative PBP binding loops; other site 713604016708 ABC-ATPase subunit interface; other site 713604016709 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 713604016710 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 713604016711 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 713604016712 active site 713604016713 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 713604016714 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 713604016715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604016716 active site 713604016717 phosphorylation site [posttranslational modification] 713604016718 intermolecular recognition site; other site 713604016719 dimerization interface [polypeptide binding]; other site 713604016720 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 713604016721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 713604016722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604016723 ATP binding site [chemical binding]; other site 713604016724 Mg2+ binding site [ion binding]; other site 713604016725 G-X-G motif; other site 713604016726 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 713604016727 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 713604016728 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604016729 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604016730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604016731 putative substrate translocation pore; other site 713604016732 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604016733 hydrophobic ligand binding site; other site 713604016734 Putative zinc-finger; Region: zf-HC2; pfam13490 713604016735 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604016736 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604016737 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604016738 DNA binding residues [nucleotide binding] 713604016739 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604016740 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 713604016741 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 713604016742 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 713604016743 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 713604016744 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 713604016745 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 713604016746 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 713604016747 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 713604016748 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 713604016749 active site 713604016750 Family description; Region: UvrD_C_2; pfam13538 713604016751 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 713604016752 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604016753 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604016754 ligand binding site [chemical binding]; other site 713604016755 flexible hinge region; other site 713604016756 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 713604016757 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 713604016758 RNA/DNA hybrid binding site [nucleotide binding]; other site 713604016759 active site 713604016760 hypothetical protein; Provisional; Region: PRK04233 713604016761 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604016762 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604016763 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 713604016764 Ca binding site [ion binding]; other site 713604016765 Ca binding site (active) [ion binding]; other site 713604016766 ligand binding site [chemical binding]; other site 713604016767 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 713604016768 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604016769 substrate binding pocket [chemical binding]; other site 713604016770 catalytic triad [active] 713604016771 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 713604016772 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 713604016773 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 713604016774 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604016775 catalytic core [active] 713604016776 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 713604016777 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 713604016778 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604016779 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604016780 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604016781 DNA binding site [nucleotide binding] 713604016782 domain linker motif; other site 713604016783 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604016784 dimerization interface [polypeptide binding]; other site 713604016785 ligand binding site [chemical binding]; other site 713604016786 Helix-turn-helix domain; Region: HTH_17; cl17695 713604016787 RES domain; Region: RES; pfam08808 713604016788 YCII-related domain; Region: YCII; cl00999 713604016789 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 713604016790 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604016791 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 713604016792 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604016793 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604016794 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604016795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604016796 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 713604016797 Walker A/P-loop; other site 713604016798 ATP binding site [chemical binding]; other site 713604016799 Q-loop/lid; other site 713604016800 ABC transporter signature motif; other site 713604016801 Walker B; other site 713604016802 D-loop; other site 713604016803 H-loop/switch region; other site 713604016804 Transposase; Region: DEDD_Tnp_IS110; pfam01548 713604016805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 713604016806 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 713604016807 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 713604016808 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604016809 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604016810 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604016811 substrate binding site [chemical binding]; other site 713604016812 oxyanion hole (OAH) forming residues; other site 713604016813 trimer interface [polypeptide binding]; other site 713604016814 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604016815 hydrophobic ligand binding site; other site 713604016816 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 713604016817 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604016818 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604016819 excinuclease ABC subunit B; Provisional; Region: PRK05298 713604016820 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604016821 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604016822 nucleotide binding region [chemical binding]; other site 713604016823 ATP-binding site [chemical binding]; other site 713604016824 Ultra-violet resistance protein B; Region: UvrB; pfam12344 713604016825 UvrB/uvrC motif; Region: UVR; pfam02151 713604016826 Protein of unknown function (DUF402); Region: DUF402; cl00979 713604016827 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 713604016828 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 713604016829 CoA-binding site [chemical binding]; other site 713604016830 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 713604016831 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 713604016832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604016833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604016834 WHG domain; Region: WHG; pfam13305 713604016835 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 713604016836 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 713604016837 RNA binding site [nucleotide binding]; other site 713604016838 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 713604016839 RNA binding site [nucleotide binding]; other site 713604016840 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 713604016841 RNA binding site [nucleotide binding]; other site 713604016842 S1 RNA binding domain; Region: S1; pfam00575 713604016843 RNA binding site [nucleotide binding]; other site 713604016844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604016845 S-adenosylmethionine binding site [chemical binding]; other site 713604016846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604016847 Coenzyme A binding pocket [chemical binding]; other site 713604016848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604016849 Walker A/P-loop; other site 713604016850 ATP binding site [chemical binding]; other site 713604016851 Q-loop/lid; other site 713604016852 ABC transporter signature motif; other site 713604016853 Walker B; other site 713604016854 H-loop/switch region; other site 713604016855 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 713604016856 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 713604016857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604016858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604016859 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 713604016860 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 713604016861 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604016862 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604016863 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604016864 putative NAD(P) binding site [chemical binding]; other site 713604016865 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604016866 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 713604016867 EF-hand domain pair; Region: EF_hand_5; pfam13499 713604016868 Ca2+ binding site [ion binding]; other site 713604016869 DNA polymerase I; Provisional; Region: PRK05755 713604016870 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 713604016871 active site 713604016872 putative 5' ssDNA interaction site; other site 713604016873 metal binding site 3; metal-binding site 713604016874 metal binding site 1 [ion binding]; metal-binding site 713604016875 metal binding site 2 [ion binding]; metal-binding site 713604016876 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 713604016877 putative DNA binding site [nucleotide binding]; other site 713604016878 putative metal binding site [ion binding]; other site 713604016879 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 713604016880 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 713604016881 active site 713604016882 DNA binding site [nucleotide binding] 713604016883 catalytic site [active] 713604016884 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604016885 CoenzymeA binding site [chemical binding]; other site 713604016886 subunit interaction site [polypeptide binding]; other site 713604016887 PHB binding site; other site 713604016888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604016889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604016890 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604016891 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604016892 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 713604016893 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 713604016894 dimerization interface [polypeptide binding]; other site 713604016895 ligand binding site [chemical binding]; other site 713604016896 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 713604016897 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604016898 TM-ABC transporter signature motif; other site 713604016899 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 713604016900 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 713604016901 TM-ABC transporter signature motif; other site 713604016902 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604016903 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 713604016904 Walker A/P-loop; other site 713604016905 ATP binding site [chemical binding]; other site 713604016906 Q-loop/lid; other site 713604016907 ABC transporter signature motif; other site 713604016908 Walker B; other site 713604016909 D-loop; other site 713604016910 H-loop/switch region; other site 713604016911 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 713604016912 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 713604016913 Walker A/P-loop; other site 713604016914 ATP binding site [chemical binding]; other site 713604016915 Q-loop/lid; other site 713604016916 ABC transporter signature motif; other site 713604016917 Walker B; other site 713604016918 D-loop; other site 713604016919 H-loop/switch region; other site 713604016920 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 713604016921 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 713604016922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604016923 active site 713604016924 phosphorylation site [posttranslational modification] 713604016925 intermolecular recognition site; other site 713604016926 dimerization interface [polypeptide binding]; other site 713604016927 ANTAR domain; Region: ANTAR; pfam03861 713604016928 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 713604016929 active site 713604016930 catalytic residues [active] 713604016931 DNA binding site [nucleotide binding] 713604016932 Int/Topo IB signature motif; other site 713604016933 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 713604016934 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 713604016935 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 713604016936 cofactor binding site; other site 713604016937 DNA binding site [nucleotide binding] 713604016938 substrate interaction site [chemical binding]; other site 713604016939 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 713604016940 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 713604016941 Ligand Binding Site [chemical binding]; other site 713604016942 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 713604016943 dimer interface [polypeptide binding]; other site 713604016944 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 713604016945 ssDNA binding site [nucleotide binding]; other site 713604016946 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604016947 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604016948 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 713604016949 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 713604016950 nudix motif; other site 713604016951 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604016952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604016953 DNA-binding site [nucleotide binding]; DNA binding site 713604016954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604016955 Coenzyme A binding pocket [chemical binding]; other site 713604016956 AAA ATPase domain; Region: AAA_16; pfam13191 713604016957 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 713604016958 DNA binding site [nucleotide binding] 713604016959 active site 713604016960 Int/Topo IB signature motif; other site 713604016961 catalytic residues [active] 713604016962 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604016963 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604016964 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604016965 DNA binding residues [nucleotide binding] 713604016966 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604016967 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 713604016968 EspG family; Region: ESX-1_EspG; pfam14011 713604016969 Histidine kinase; Region: HisKA_3; pfam07730 713604016970 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604016971 ATP binding site [chemical binding]; other site 713604016972 Mg2+ binding site [ion binding]; other site 713604016973 G-X-G motif; other site 713604016974 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604016975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604016976 active site 713604016977 phosphorylation site [posttranslational modification] 713604016978 intermolecular recognition site; other site 713604016979 dimerization interface [polypeptide binding]; other site 713604016980 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604016981 DNA binding residues [nucleotide binding] 713604016982 dimerization interface [polypeptide binding]; other site 713604016983 RDD family; Region: RDD; pfam06271 713604016984 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 713604016985 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 713604016986 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604016987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604016988 active site 713604016989 phosphorylation site [posttranslational modification] 713604016990 intermolecular recognition site; other site 713604016991 dimerization interface [polypeptide binding]; other site 713604016992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604016993 DNA binding residues [nucleotide binding] 713604016994 dimerization interface [polypeptide binding]; other site 713604016995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604016996 Histidine kinase; Region: HisKA_3; pfam07730 713604016997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604016998 ATP binding site [chemical binding]; other site 713604016999 Mg2+ binding site [ion binding]; other site 713604017000 G-X-G motif; other site 713604017001 CHAT domain; Region: CHAT; cl17868 713604017002 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604017003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017004 NAD(P) binding site [chemical binding]; other site 713604017005 active site 713604017006 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 713604017007 Q-loop/lid; other site 713604017008 ABC transporter signature motif; other site 713604017009 Walker B; other site 713604017010 D-loop; other site 713604017011 H-loop/switch region; other site 713604017012 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 713604017013 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604017014 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017015 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017016 DNA binding residues [nucleotide binding] 713604017017 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 713604017018 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 713604017019 active site 713604017020 NAD binding site [chemical binding]; other site 713604017021 metal binding site [ion binding]; metal-binding site 713604017022 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 713604017023 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604017024 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604017025 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604017026 NAD(P) binding site [chemical binding]; other site 713604017027 catalytic residues [active] 713604017028 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 713604017029 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604017030 active site pocket [active] 713604017031 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 713604017032 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604017033 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 713604017034 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604017035 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604017036 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604017037 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604017038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604017039 non-specific DNA binding site [nucleotide binding]; other site 713604017040 salt bridge; other site 713604017041 sequence-specific DNA binding site [nucleotide binding]; other site 713604017042 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 713604017043 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604017044 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604017045 conserved cys residue [active] 713604017046 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604017047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604017048 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604017049 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604017050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 713604017051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017052 short chain dehydrogenase; Provisional; Region: PRK06197 713604017053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017054 NAD(P) binding site [chemical binding]; other site 713604017055 active site 713604017056 Helix-turn-helix domain; Region: HTH_31; pfam13560 713604017057 ANTAR domain; Region: ANTAR; pfam03861 713604017058 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 713604017059 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017060 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 713604017061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017062 DNA binding residues [nucleotide binding] 713604017063 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604017064 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604017065 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 713604017066 Peptidase family M28; Region: Peptidase_M28; pfam04389 713604017067 metal binding site [ion binding]; metal-binding site 713604017068 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 713604017069 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 713604017070 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604017071 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 713604017072 dimer interface [polypeptide binding]; other site 713604017073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604017074 catalytic residue [active] 713604017075 Condensation domain; Region: Condensation; pfam00668 713604017076 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017077 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 713604017078 Condensation domain; Region: Condensation; pfam00668 713604017079 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017080 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604017081 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604017082 Condensation domain; Region: Condensation; pfam00668 713604017083 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017084 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604017085 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604017086 active site 713604017087 AMP binding site [chemical binding]; other site 713604017088 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604017089 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604017090 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604017091 acyl-activating enzyme (AAE) consensus motif; other site 713604017092 AMP binding site [chemical binding]; other site 713604017093 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604017094 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604017095 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604017096 acyl-activating enzyme (AAE) consensus motif; other site 713604017097 AMP binding site [chemical binding]; other site 713604017098 Condensation domain; Region: Condensation; pfam00668 713604017099 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017100 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604017101 MbtH-like protein; Region: MbtH; cl01279 713604017102 acyl-CoA synthetase; Validated; Region: PRK05850 713604017103 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604017104 acyl-activating enzyme (AAE) consensus motif; other site 713604017105 active site 713604017106 Condensation domain; Region: Condensation; pfam00668 713604017107 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017108 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604017109 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604017110 acyl-activating enzyme (AAE) consensus motif; other site 713604017111 AMP binding site [chemical binding]; other site 713604017112 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604017113 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604017114 Cytochrome P450; Region: p450; cl12078 713604017115 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 713604017116 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604017117 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604017118 acyl-activating enzyme (AAE) consensus motif; other site 713604017119 AMP binding site [chemical binding]; other site 713604017120 Thioesterase domain; Region: Thioesterase; pfam00975 713604017121 Condensation domain; Region: Condensation; pfam00668 713604017122 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 713604017123 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 713604017124 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 713604017125 acyl-activating enzyme (AAE) consensus motif; other site 713604017126 AMP binding site [chemical binding]; other site 713604017127 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604017128 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604017129 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604017130 acyl-activating enzyme (AAE) consensus motif; other site 713604017131 AMP binding site [chemical binding]; other site 713604017132 active site 713604017133 CoA binding site [chemical binding]; other site 713604017134 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604017135 AAA ATPase domain; Region: AAA_16; pfam13191 713604017136 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017138 DNA binding residues [nucleotide binding] 713604017139 dimerization interface [polypeptide binding]; other site 713604017140 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 713604017141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604017142 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604017143 dimerization interface [polypeptide binding]; other site 713604017144 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 713604017145 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 713604017146 CGNR zinc finger; Region: zf-CGNR; pfam11706 713604017147 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604017148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604017149 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604017150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017151 NAD(P) binding site [chemical binding]; other site 713604017152 active site 713604017153 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 713604017154 Cell division protein FtsQ; Region: FtsQ; pfam03799 713604017155 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 713604017156 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 713604017157 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713604017158 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713604017159 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 713604017160 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 713604017161 homodimer interface [polypeptide binding]; other site 713604017162 active site 713604017163 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 713604017164 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 713604017165 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 713604017166 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713604017167 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713604017168 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 713604017169 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 713604017170 Mg++ binding site [ion binding]; other site 713604017171 putative catalytic motif [active] 713604017172 putative substrate binding site [chemical binding]; other site 713604017173 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 713604017174 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 713604017175 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713604017176 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713604017177 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 713604017178 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 713604017179 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713604017180 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713604017181 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 713604017182 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 713604017183 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 713604017184 MraW methylase family; Region: Methyltransf_5; pfam01795 713604017185 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 713604017186 cell division protein MraZ; Reviewed; Region: PRK00326 713604017187 MraZ protein; Region: MraZ; pfam02381 713604017188 MraZ protein; Region: MraZ; pfam02381 713604017189 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604017190 EspG family; Region: ESX-1_EspG; pfam14011 713604017191 MoxR-like ATPases [General function prediction only]; Region: COG0714 713604017192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604017193 ATP binding site [chemical binding]; other site 713604017194 Walker A motif; other site 713604017195 Walker B motif; other site 713604017196 arginine finger; other site 713604017197 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 713604017198 Protein of unknown function DUF58; Region: DUF58; pfam01882 713604017199 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 713604017200 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 713604017201 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 713604017202 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 713604017203 active site 713604017204 DNA polymerase IV; Validated; Region: PRK02406 713604017205 DNA binding site [nucleotide binding] 713604017206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604017207 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604017208 S-adenosylmethionine binding site [chemical binding]; other site 713604017209 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 713604017210 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604017211 P-loop; other site 713604017212 Magnesium ion binding site [ion binding]; other site 713604017213 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604017214 Magnesium ion binding site [ion binding]; other site 713604017215 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 713604017216 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 713604017217 putative DNA binding site [nucleotide binding]; other site 713604017218 catalytic residue [active] 713604017219 putative H2TH interface [polypeptide binding]; other site 713604017220 putative catalytic residues [active] 713604017221 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604017222 adenosine deaminase; Provisional; Region: PRK09358 713604017223 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 713604017224 active site 713604017225 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604017226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604017227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604017228 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 713604017229 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 713604017230 quinone interaction residues [chemical binding]; other site 713604017231 active site 713604017232 catalytic residues [active] 713604017233 FMN binding site [chemical binding]; other site 713604017234 substrate binding site [chemical binding]; other site 713604017235 Amidase; Region: Amidase; cl11426 713604017236 allophanate hydrolase; Provisional; Region: PRK08186 713604017237 CobD/Cbib protein; Region: CobD_Cbib; cl00561 713604017238 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 713604017239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604017240 non-specific DNA binding site [nucleotide binding]; other site 713604017241 salt bridge; other site 713604017242 sequence-specific DNA binding site [nucleotide binding]; other site 713604017243 Competence-damaged protein; Region: CinA; pfam02464 713604017244 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 713604017245 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 713604017246 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 713604017247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604017248 FeS/SAM binding site; other site 713604017249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604017250 Coenzyme A binding pocket [chemical binding]; other site 713604017251 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 713604017252 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 713604017253 FMN binding site [chemical binding]; other site 713604017254 dimer interface [polypeptide binding]; other site 713604017255 RloB-like protein; Region: RloB; pfam13707 713604017256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604017257 AAA domain; Region: AAA_21; pfam13304 713604017258 Walker A/P-loop; other site 713604017259 ATP binding site [chemical binding]; other site 713604017260 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 713604017261 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604017262 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 713604017263 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604017264 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604017265 putative acyl-acceptor binding pocket; other site 713604017266 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 713604017267 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604017268 EamA-like transporter family; Region: EamA; pfam00892 713604017269 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 713604017270 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604017271 metal ion-dependent adhesion site (MIDAS); other site 713604017272 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 713604017273 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604017274 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 713604017275 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 713604017276 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 713604017277 dimer interface [polypeptide binding]; other site 713604017278 active site 713604017279 catalytic residue [active] 713604017280 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604017281 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604017282 active site 713604017283 ATP binding site [chemical binding]; other site 713604017284 substrate binding site [chemical binding]; other site 713604017285 activation loop (A-loop); other site 713604017286 Septum formation; Region: Septum_form; pfam13845 713604017287 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 713604017288 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 713604017289 Uncharacterized conserved protein [Function unknown]; Region: COG3603 713604017290 Family description; Region: ACT_7; pfam13840 713604017291 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 713604017292 HicB family; Region: HicB; pfam05534 713604017293 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604017294 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604017295 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604017296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 713604017297 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 713604017298 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604017299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604017300 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604017301 non-specific DNA binding site [nucleotide binding]; other site 713604017302 salt bridge; other site 713604017303 sequence-specific DNA binding site [nucleotide binding]; other site 713604017304 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604017305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604017306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604017307 dimerization interface [polypeptide binding]; other site 713604017308 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 713604017309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604017310 dihydrodipicolinate reductase; Provisional; Region: PRK00048 713604017311 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 713604017312 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 713604017313 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 713604017314 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 713604017315 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 713604017316 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 713604017317 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 713604017318 oligomer interface [polypeptide binding]; other site 713604017319 RNA binding site [nucleotide binding]; other site 713604017320 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 713604017321 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 713604017322 RNase E interface [polypeptide binding]; other site 713604017323 trimer interface [polypeptide binding]; other site 713604017324 active site 713604017325 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 713604017326 putative nucleic acid binding region [nucleotide binding]; other site 713604017327 G-X-X-G motif; other site 713604017328 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 713604017329 RNA binding site [nucleotide binding]; other site 713604017330 domain interface; other site 713604017331 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 713604017332 16S/18S rRNA binding site [nucleotide binding]; other site 713604017333 S13e-L30e interaction site [polypeptide binding]; other site 713604017334 25S rRNA binding site [nucleotide binding]; other site 713604017335 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 713604017336 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 713604017337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604017338 non-specific DNA binding site [nucleotide binding]; other site 713604017339 salt bridge; other site 713604017340 sequence-specific DNA binding site [nucleotide binding]; other site 713604017341 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 713604017342 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 713604017343 active site 713604017344 Riboflavin kinase; Region: Flavokinase; smart00904 713604017345 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 713604017346 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 713604017347 RNA binding site [nucleotide binding]; other site 713604017348 active site 713604017349 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 713604017350 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604017351 active site 713604017352 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604017353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604017354 putative substrate translocation pore; other site 713604017355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604017356 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 713604017357 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 713604017358 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 713604017359 DHH family; Region: DHH; pfam01368 713604017360 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 713604017361 Methyltransferase domain; Region: Methyltransf_26; pfam13659 713604017362 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 713604017363 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 713604017364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017365 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604017367 S-adenosylmethionine binding site [chemical binding]; other site 713604017368 Putative esterase; Region: Esterase; pfam00756 713604017369 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 713604017370 Protein of unknown function (DUF503); Region: DUF503; pfam04456 713604017371 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 713604017372 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 713604017373 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 713604017374 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 713604017375 G1 box; other site 713604017376 putative GEF interaction site [polypeptide binding]; other site 713604017377 GTP/Mg2+ binding site [chemical binding]; other site 713604017378 Switch I region; other site 713604017379 G2 box; other site 713604017380 G3 box; other site 713604017381 Switch II region; other site 713604017382 G4 box; other site 713604017383 G5 box; other site 713604017384 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 713604017385 Translation-initiation factor 2; Region: IF-2; pfam11987 713604017386 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 713604017387 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 713604017388 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 713604017389 NusA N-terminal domain; Region: NusA_N; pfam08529 713604017390 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 713604017391 RNA binding site [nucleotide binding]; other site 713604017392 homodimer interface [polypeptide binding]; other site 713604017393 NusA-like KH domain; Region: KH_5; pfam13184 713604017394 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 713604017395 G-X-X-G motif; other site 713604017396 ribosome maturation protein RimP; Reviewed; Region: PRK00092 713604017397 Sm and related proteins; Region: Sm_like; cl00259 713604017398 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 713604017399 putative oligomer interface [polypeptide binding]; other site 713604017400 putative RNA binding site [nucleotide binding]; other site 713604017401 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 713604017402 dinuclear metal binding motif [ion binding]; other site 713604017403 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604017404 catalytic residue [active] 713604017405 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 713604017406 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 713604017407 oligomerization interface [polypeptide binding]; other site 713604017408 active site 713604017409 metal binding site [ion binding]; metal-binding site 713604017410 Predicted membrane protein [Function unknown]; Region: COG3428 713604017411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017412 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 713604017413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604017414 Histidine kinase; Region: HisKA_3; pfam07730 713604017415 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604017416 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604017418 active site 713604017419 phosphorylation site [posttranslational modification] 713604017420 intermolecular recognition site; other site 713604017421 dimerization interface [polypeptide binding]; other site 713604017422 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017423 DNA binding residues [nucleotide binding] 713604017424 dimerization interface [polypeptide binding]; other site 713604017425 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 713604017426 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 713604017427 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604017428 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604017429 dimerization interface [polypeptide binding]; other site 713604017430 putative DNA binding site [nucleotide binding]; other site 713604017431 putative Zn2+ binding site [ion binding]; other site 713604017432 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 713604017433 putative hydrophobic ligand binding site [chemical binding]; other site 713604017434 protein interface [polypeptide binding]; other site 713604017435 gate; other site 713604017436 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604017437 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 713604017438 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604017439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604017440 active site 713604017441 phosphorylation site [posttranslational modification] 713604017442 intermolecular recognition site; other site 713604017443 dimerization interface [polypeptide binding]; other site 713604017444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604017445 DNA binding site [nucleotide binding] 713604017446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604017447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604017448 dimer interface [polypeptide binding]; other site 713604017449 phosphorylation site [posttranslational modification] 713604017450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604017451 ATP binding site [chemical binding]; other site 713604017452 Mg2+ binding site [ion binding]; other site 713604017453 G-X-G motif; other site 713604017454 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017455 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017456 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 713604017457 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604017458 AAA domain; Region: AAA_22; pfam13401 713604017459 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017460 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604017462 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 713604017463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604017464 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604017465 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604017466 enoyl-CoA hydratase; Provisional; Region: PRK08252 713604017467 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604017468 substrate binding site [chemical binding]; other site 713604017469 oxyanion hole (OAH) forming residues; other site 713604017470 trimer interface [polypeptide binding]; other site 713604017471 acetoacetate decarboxylase; Provisional; Region: PRK02265 713604017472 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 713604017473 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604017474 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604017475 acyl-coenzyme A oxidase; Region: PLN02526 713604017476 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604017477 active site 713604017478 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604017479 short chain dehydrogenase; Provisional; Region: PRK07024 713604017480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017481 NAD(P) binding site [chemical binding]; other site 713604017482 active site 713604017483 RNA polymerase factor sigma-70; Validated; Region: PRK08241 713604017484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017485 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017486 DNA binding residues [nucleotide binding] 713604017487 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604017488 Transcription factor WhiB; Region: Whib; pfam02467 713604017489 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604017490 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604017491 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604017492 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017493 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017494 DNA binding residues [nucleotide binding] 713604017495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604017496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604017497 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604017498 dimerization interface [polypeptide binding]; other site 713604017499 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 713604017500 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 713604017501 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 713604017502 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 713604017503 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 713604017504 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 713604017505 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604017506 Cytochrome P450; Region: p450; cl12078 713604017507 Winged helix-turn helix; Region: HTH_29; pfam13551 713604017508 Homeodomain-like domain; Region: HTH_32; pfam13565 713604017509 DDE superfamily endonuclease; Region: DDE_3; pfam13358 713604017510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017511 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604017512 NAD(P) binding site [chemical binding]; other site 713604017513 active site 713604017514 RibD C-terminal domain; Region: RibD_C; cl17279 713604017515 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604017516 dimerization interface [polypeptide binding]; other site 713604017517 putative DNA binding site [nucleotide binding]; other site 713604017518 putative Zn2+ binding site [ion binding]; other site 713604017519 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 713604017520 putative hydrophobic ligand binding site [chemical binding]; other site 713604017521 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604017522 DNA binding site [nucleotide binding] 713604017523 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604017524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604017525 binding surface 713604017526 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017527 TPR motif; other site 713604017528 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017529 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 713604017530 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 713604017531 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 713604017532 kynureninase; Region: kynureninase; TIGR01814 713604017533 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604017534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604017535 catalytic residue [active] 713604017536 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604017537 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 713604017538 haloalkane dehalogenase; Provisional; Region: PRK03592 713604017539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017541 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 713604017542 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604017543 Di-iron ligands [ion binding]; other site 713604017544 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 713604017545 Rubredoxin; Region: Rubredoxin; pfam00301 713604017546 iron binding site [ion binding]; other site 713604017547 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604017548 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604017549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604017550 ATP binding site [chemical binding]; other site 713604017551 Mg2+ binding site [ion binding]; other site 713604017552 G-X-G motif; other site 713604017553 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604017554 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604017555 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604017556 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604017557 G2 box; other site 713604017558 Switch I region; other site 713604017559 G3 box; other site 713604017560 Switch II region; other site 713604017561 GTP/Mg2+ binding site [chemical binding]; other site 713604017562 G4 box; other site 713604017563 G5 box; other site 713604017564 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 713604017565 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 713604017566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017567 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604017568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017570 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 713604017571 Cupin domain; Region: Cupin_2; cl17218 713604017572 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604017573 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 713604017574 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 713604017575 inhibitor binding site; inhibition site 713604017576 active site 713604017577 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604017578 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604017579 YCII-related domain; Region: YCII; cl00999 713604017580 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604017581 PGAP1-like protein; Region: PGAP1; pfam07819 713604017582 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604017583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017585 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604017586 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604017587 putative NAD(P) binding site [chemical binding]; other site 713604017588 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604017589 AAA ATPase domain; Region: AAA_16; pfam13191 713604017590 Caspase domain; Region: Peptidase_C14; pfam00656 713604017591 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 713604017592 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 713604017593 nucleotide binding site [chemical binding]; other site 713604017594 putative NEF/HSP70 interaction site [polypeptide binding]; other site 713604017595 SBD interface [polypeptide binding]; other site 713604017596 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604017597 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604017598 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604017599 active site 713604017600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017601 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 713604017602 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604017603 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604017604 putative sugar binding sites [chemical binding]; other site 713604017605 Q-X-W motif; other site 713604017606 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 713604017607 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604017608 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604017609 putative sugar binding sites [chemical binding]; other site 713604017610 Q-X-W motif; other site 713604017611 DEAD-like helicases superfamily; Region: DEXDc; smart00487 713604017612 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604017613 Family description; Region: UvrD_C_2; pfam13538 713604017614 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604017615 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017617 DNA binding residues [nucleotide binding] 713604017618 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604017619 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604017620 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604017621 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 713604017622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017624 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017626 DNA binding residues [nucleotide binding] 713604017627 dimerization interface [polypeptide binding]; other site 713604017628 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 713604017629 polypeptide substrate binding site [polypeptide binding]; other site 713604017630 active site 713604017631 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604017632 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 713604017633 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604017634 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604017635 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604017636 active site 713604017637 catalytic triad [active] 713604017638 oxyanion hole [active] 713604017639 Phosphotransferase enzyme family; Region: APH; pfam01636 713604017640 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 713604017641 active site 713604017642 ATP binding site [chemical binding]; other site 713604017643 substrate binding site [chemical binding]; other site 713604017644 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 713604017645 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017646 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604017647 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 713604017648 active site 713604017649 TDP-binding site; other site 713604017650 acceptor substrate-binding pocket; other site 713604017651 homodimer interface [polypeptide binding]; other site 713604017652 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604017653 DNA binding site [nucleotide binding] 713604017654 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604017655 AAA ATPase domain; Region: AAA_16; pfam13191 713604017656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604017657 TPR motif; other site 713604017658 binding surface 713604017659 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604017660 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604017661 binding surface 713604017662 TPR motif; other site 713604017663 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604017664 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 713604017665 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604017666 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604017667 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604017668 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604017669 active site 713604017670 catalytic tetrad [active] 713604017671 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604017672 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 713604017673 AAA ATPase domain; Region: AAA_16; pfam13191 713604017674 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017675 DNA binding residues [nucleotide binding] 713604017676 dimerization interface [polypeptide binding]; other site 713604017677 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 713604017678 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 713604017679 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 713604017680 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 713604017681 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604017682 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 713604017683 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604017684 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 713604017685 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 713604017686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017687 dimerization interface [polypeptide binding]; other site 713604017688 DNA binding residues [nucleotide binding] 713604017689 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604017690 acyl-coenzyme A oxidase; Region: PLN02526 713604017691 active site 713604017692 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 713604017693 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 713604017694 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 713604017695 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604017696 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 713604017697 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 713604017698 acyl-activating enzyme (AAE) consensus motif; other site 713604017699 putative AMP binding site [chemical binding]; other site 713604017700 putative active site [active] 713604017701 putative CoA binding site [chemical binding]; other site 713604017702 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604017703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017704 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604017705 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604017706 AAA ATPase domain; Region: AAA_16; pfam13191 713604017707 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017708 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017709 DNA binding residues [nucleotide binding] 713604017710 dimerization interface [polypeptide binding]; other site 713604017711 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017713 DNA binding residues [nucleotide binding] 713604017714 dimerization interface [polypeptide binding]; other site 713604017715 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604017716 Predicted acyl esterases [General function prediction only]; Region: COG2936 713604017717 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604017718 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 713604017719 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 713604017720 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604017721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604017722 putative substrate translocation pore; other site 713604017723 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 713604017724 putative ligand binding site [chemical binding]; other site 713604017725 putative catalytic site [active] 713604017726 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 713604017727 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 713604017728 sugar binding site [chemical binding]; other site 713604017729 Muconolactone delta-isomerase; Region: MIase; cl01992 713604017730 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604017731 anti sigma factor interaction site; other site 713604017732 regulatory phosphorylation site [posttranslational modification]; other site 713604017733 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 713604017734 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 713604017735 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604017736 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604017737 ATP binding site [chemical binding]; other site 713604017738 Mg2+ binding site [ion binding]; other site 713604017739 G-X-G motif; other site 713604017740 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604017741 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 713604017742 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604017743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604017744 Walker A/P-loop; other site 713604017745 ATP binding site [chemical binding]; other site 713604017746 Q-loop/lid; other site 713604017747 ABC transporter signature motif; other site 713604017748 Walker B; other site 713604017749 D-loop; other site 713604017750 H-loop/switch region; other site 713604017751 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604017752 Histidine kinase; Region: HisKA_3; pfam07730 713604017753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604017754 ATP binding site [chemical binding]; other site 713604017755 Mg2+ binding site [ion binding]; other site 713604017756 G-X-G motif; other site 713604017757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604017759 active site 713604017760 phosphorylation site [posttranslational modification] 713604017761 intermolecular recognition site; other site 713604017762 dimerization interface [polypeptide binding]; other site 713604017763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017764 DNA binding residues [nucleotide binding] 713604017765 dimerization interface [polypeptide binding]; other site 713604017766 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604017767 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604017768 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 713604017769 Penicillinase repressor; Region: Pencillinase_R; pfam03965 713604017770 Peptidase family M48; Region: Peptidase_M48; cl12018 713604017771 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 713604017772 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 713604017773 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604017774 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 713604017775 Walker A/P-loop; other site 713604017776 ATP binding site [chemical binding]; other site 713604017777 Q-loop/lid; other site 713604017778 ABC transporter signature motif; other site 713604017779 Walker B; other site 713604017780 D-loop; other site 713604017781 H-loop/switch region; other site 713604017782 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604017783 Histidine kinase; Region: HisKA_3; pfam07730 713604017784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604017785 ATP binding site [chemical binding]; other site 713604017786 Mg2+ binding site [ion binding]; other site 713604017787 G-X-G motif; other site 713604017788 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604017789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604017790 active site 713604017791 phosphorylation site [posttranslational modification] 713604017792 intermolecular recognition site; other site 713604017793 dimerization interface [polypeptide binding]; other site 713604017794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604017795 dimerization interface [polypeptide binding]; other site 713604017796 DNA binding residues [nucleotide binding] 713604017797 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604017798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604017799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017800 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604017801 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 713604017802 NADP binding site [chemical binding]; other site 713604017803 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 713604017804 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604017805 NADP binding site [chemical binding]; other site 713604017806 Cupin domain; Region: Cupin_2; pfam07883 713604017807 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 713604017808 DJ-1 family protein; Region: not_thiJ; TIGR01383 713604017809 conserved cys residue [active] 713604017810 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604017811 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604017812 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604017813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604017814 putative substrate translocation pore; other site 713604017815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604017816 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 713604017817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017818 NAD(P) binding site [chemical binding]; other site 713604017819 active site 713604017820 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604017821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017822 NAD(P) binding site [chemical binding]; other site 713604017823 active site 713604017824 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 713604017825 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604017826 MarR family; Region: MarR_2; pfam12802 713604017827 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604017828 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604017829 conserved cys residue [active] 713604017830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604017831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604017832 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604017833 Zn2+ binding site [ion binding]; other site 713604017834 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 713604017835 Mg2+ binding site [ion binding]; other site 713604017836 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 713604017837 homotrimer interaction site [polypeptide binding]; other site 713604017838 putative active site [active] 713604017839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604017840 GAF domain; Region: GAF; pfam01590 713604017841 ANTAR domain; Region: ANTAR; pfam03861 713604017842 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 713604017843 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604017844 metal-binding site [ion binding] 713604017845 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604017846 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604017847 metal-binding site [ion binding] 713604017848 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 713604017849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017851 DNA binding residues [nucleotide binding] 713604017852 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604017853 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017854 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017855 DNA binding residues [nucleotide binding] 713604017856 Putative zinc-finger; Region: zf-HC2; pfam13490 713604017857 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 713604017858 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 713604017859 DJ-1 family protein; Region: not_thiJ; TIGR01383 713604017860 conserved cys residue [active] 713604017861 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 713604017862 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 713604017863 Walker A/P-loop; other site 713604017864 ATP binding site [chemical binding]; other site 713604017865 Q-loop/lid; other site 713604017866 ABC transporter signature motif; other site 713604017867 Walker B; other site 713604017868 D-loop; other site 713604017869 H-loop/switch region; other site 713604017870 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 713604017871 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 713604017872 putative PBP binding regions; other site 713604017873 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 713604017874 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 713604017875 intersubunit interface [polypeptide binding]; other site 713604017876 CopC domain; Region: CopC; pfam04234 713604017877 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 713604017878 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604017879 metal-binding site [ion binding] 713604017880 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604017881 Soluble P-type ATPase [General function prediction only]; Region: COG4087 713604017882 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 713604017883 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 713604017884 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 713604017885 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 713604017886 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604017887 anti sigma factor interaction site; other site 713604017888 regulatory phosphorylation site [posttranslational modification]; other site 713604017889 ANTAR domain; Region: ANTAR; pfam03861 713604017890 GAF domain; Region: GAF; pfam01590 713604017891 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 713604017892 ANTAR domain; Region: ANTAR; pfam03861 713604017893 ANTAR domain; Region: ANTAR; pfam03861 713604017894 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 713604017895 GAF domain; Region: GAF; pfam01590 713604017896 GAF domain; Region: GAF_2; pfam13185 713604017897 ANTAR domain; Region: ANTAR; pfam03861 713604017898 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604017899 OsmC-like protein; Region: OsmC; cl00767 713604017900 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604017901 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 713604017902 molybdopterin cofactor binding site; other site 713604017903 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 713604017904 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 713604017905 NAD binding site [chemical binding]; other site 713604017906 catalytic Zn binding site [ion binding]; other site 713604017907 structural Zn binding site [ion binding]; other site 713604017908 ANTAR domain; Region: ANTAR; pfam03861 713604017909 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 713604017910 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 713604017911 putative NAD(P) binding site [chemical binding]; other site 713604017912 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604017913 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 713604017914 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 713604017915 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604017916 NAD(P) binding site [chemical binding]; other site 713604017917 catalytic residues [active] 713604017918 Predicted membrane protein [Function unknown]; Region: COG4129 713604017919 thiamine pyrophosphate protein; Provisional; Region: PRK08273 713604017920 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 713604017921 PYR/PP interface [polypeptide binding]; other site 713604017922 dimer interface [polypeptide binding]; other site 713604017923 tetramer interface [polypeptide binding]; other site 713604017924 TPP binding site [chemical binding]; other site 713604017925 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604017926 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 713604017927 TPP-binding site [chemical binding]; other site 713604017928 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 713604017929 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 713604017930 putative active site pocket [active] 713604017931 putative metal binding site [ion binding]; other site 713604017932 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604017933 FAD binding domain; Region: FAD_binding_4; pfam01565 713604017934 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 713604017935 ChaB; Region: ChaB; pfam06150 713604017936 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 713604017937 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 713604017938 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 713604017939 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604017940 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 713604017941 XFP N-terminal domain; Region: XFP_N; pfam09364 713604017942 putative phosphoketolase; Provisional; Region: PRK05261 713604017943 XFP C-terminal domain; Region: XFP_C; pfam09363 713604017944 Hemerythrin-like domain; Region: Hr-like; cd12108 713604017945 Fe binding site [ion binding]; other site 713604017946 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 713604017947 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 713604017948 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604017949 NAD binding site [chemical binding]; other site 713604017950 catalytic Zn binding site [ion binding]; other site 713604017951 structural Zn binding site [ion binding]; other site 713604017952 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 713604017953 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 713604017954 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 713604017955 transmembrane helices; other site 713604017956 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604017957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604017958 Walker A/P-loop; other site 713604017959 ATP binding site [chemical binding]; other site 713604017960 Q-loop/lid; other site 713604017961 ABC transporter signature motif; other site 713604017962 Walker B; other site 713604017963 D-loop; other site 713604017964 H-loop/switch region; other site 713604017965 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 713604017966 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604017967 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 713604017968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604017969 S-adenosylmethionine binding site [chemical binding]; other site 713604017970 DNA primase; Validated; Region: dnaG; PRK05667 713604017971 CHC2 zinc finger; Region: zf-CHC2; pfam01807 713604017972 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 713604017973 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 713604017974 active site 713604017975 metal binding site [ion binding]; metal-binding site 713604017976 interdomain interaction site; other site 713604017977 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 713604017978 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 713604017979 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604017980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604017981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604017982 DNA binding residues [nucleotide binding] 713604017983 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604017984 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604017985 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604017986 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604017987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604017988 MarR family; Region: MarR_2; pfam12802 713604017989 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604017990 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604017991 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 713604017992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604017993 Protein of unknown function (DUF664); Region: DUF664; pfam04978 713604017994 DinB superfamily; Region: DinB_2; pfam12867 713604017995 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 713604017996 serpin-like protein; Provisional; Region: PHA02660 713604017997 reactive center loop; other site 713604017998 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 713604017999 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604018000 Zn2+ binding site [ion binding]; other site 713604018001 Mg2+ binding site [ion binding]; other site 713604018002 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 713604018003 Uncharacterized conserved protein [Function unknown]; Region: COG1434 713604018004 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 713604018005 putative active site [active] 713604018006 Response regulator receiver domain; Region: Response_reg; pfam00072 713604018007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018008 active site 713604018009 phosphorylation site [posttranslational modification] 713604018010 intermolecular recognition site; other site 713604018011 dimerization interface [polypeptide binding]; other site 713604018012 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604018013 DNA binding residues [nucleotide binding] 713604018014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604018015 Histidine kinase; Region: HisKA_3; pfam07730 713604018016 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604018017 ATP binding site [chemical binding]; other site 713604018018 Mg2+ binding site [ion binding]; other site 713604018019 G-X-G motif; other site 713604018020 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604018021 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604018022 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604018023 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604018024 Walker A/P-loop; other site 713604018025 ATP binding site [chemical binding]; other site 713604018026 Q-loop/lid; other site 713604018027 ABC transporter signature motif; other site 713604018028 Walker B; other site 713604018029 D-loop; other site 713604018030 H-loop/switch region; other site 713604018031 glycyl-tRNA synthetase; Provisional; Region: PRK04173 713604018032 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604018033 motif 1; other site 713604018034 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 713604018035 motif 1; other site 713604018036 dimer interface [polypeptide binding]; other site 713604018037 active site 713604018038 motif 2; other site 713604018039 motif 3; other site 713604018040 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 713604018041 anticodon binding site; other site 713604018042 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604018043 active site 713604018044 putative catalytic site [active] 713604018045 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 713604018046 active site 713604018047 catalytic site [active] 713604018048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604018049 dimerization interface [polypeptide binding]; other site 713604018050 putative DNA binding site [nucleotide binding]; other site 713604018051 putative Zn2+ binding site [ion binding]; other site 713604018052 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 713604018053 metal binding site 2 [ion binding]; metal-binding site 713604018054 putative DNA binding helix; other site 713604018055 metal binding site 1 [ion binding]; metal-binding site 713604018056 dimer interface [polypeptide binding]; other site 713604018057 structural Zn2+ binding site [ion binding]; other site 713604018058 TIGR03943 family protein; Region: TIGR03943 713604018059 Predicted permease; Region: DUF318; cl17795 713604018060 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 713604018061 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 713604018062 catalytic residue [active] 713604018063 putative FPP diphosphate binding site; other site 713604018064 putative FPP binding hydrophobic cleft; other site 713604018065 dimer interface [polypeptide binding]; other site 713604018066 putative IPP diphosphate binding site; other site 713604018067 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 713604018068 Recombination protein O N terminal; Region: RecO_N; pfam11967 713604018069 Recombination protein O C terminal; Region: RecO_C; pfam02565 713604018070 Interferon-induced transmembrane protein; Region: CD225; pfam04505 713604018071 RDD family; Region: RDD; pfam06271 713604018072 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 713604018073 Interferon-induced transmembrane protein; Region: CD225; pfam04505 713604018074 Interferon-induced transmembrane protein; Region: CD225; pfam04505 713604018075 GTPase Era; Reviewed; Region: era; PRK00089 713604018076 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 713604018077 G1 box; other site 713604018078 GTP/Mg2+ binding site [chemical binding]; other site 713604018079 Switch I region; other site 713604018080 G2 box; other site 713604018081 Switch II region; other site 713604018082 G3 box; other site 713604018083 G4 box; other site 713604018084 G5 box; other site 713604018085 KH domain; Region: KH_2; pfam07650 713604018086 Domain of unknown function DUF21; Region: DUF21; pfam01595 713604018087 FOG: CBS domain [General function prediction only]; Region: COG0517 713604018088 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 713604018089 Transporter associated domain; Region: CorC_HlyC; smart01091 713604018090 metal-binding heat shock protein; Provisional; Region: PRK00016 713604018091 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 713604018092 PhoH-like protein; Region: PhoH; pfam02562 713604018093 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 713604018094 nucleotide binding site/active site [active] 713604018095 HIT family signature motif; other site 713604018096 catalytic residue [active] 713604018097 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 713604018098 chaperone protein DnaJ; Provisional; Region: PRK14278 713604018099 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 713604018100 HSP70 interaction site [polypeptide binding]; other site 713604018101 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 713604018102 Zn binding sites [ion binding]; other site 713604018103 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 713604018104 dimer interface [polypeptide binding]; other site 713604018105 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 713604018106 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 713604018107 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604018108 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604018109 active site 713604018110 catalytic tetrad [active] 713604018111 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 713604018112 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 713604018113 tetrameric interface [polypeptide binding]; other site 713604018114 NAD binding site [chemical binding]; other site 713604018115 catalytic residues [active] 713604018116 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 713604018117 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 713604018118 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604018119 Subtilisin inhibitor-like; Region: SSI; cl11594 713604018120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604018121 sequence-specific DNA binding site [nucleotide binding]; other site 713604018122 salt bridge; other site 713604018123 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604018124 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 713604018125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604018126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018127 dimerization interface [polypeptide binding]; other site 713604018128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604018129 dimer interface [polypeptide binding]; other site 713604018130 phosphorylation site [posttranslational modification] 713604018131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018132 ATP binding site [chemical binding]; other site 713604018133 Mg2+ binding site [ion binding]; other site 713604018134 G-X-G motif; other site 713604018135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604018136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018137 active site 713604018138 phosphorylation site [posttranslational modification] 713604018139 intermolecular recognition site; other site 713604018140 dimerization interface [polypeptide binding]; other site 713604018141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604018142 DNA binding site [nucleotide binding] 713604018143 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 713604018144 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 713604018145 Na binding site [ion binding]; other site 713604018146 putative substrate binding site [chemical binding]; other site 713604018147 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 713604018148 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 713604018149 active site 713604018150 catalytic triad [active] 713604018151 dimer interface [polypeptide binding]; other site 713604018152 phenylhydantoinase; Validated; Region: PRK08323 713604018153 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 713604018154 tetramer interface [polypeptide binding]; other site 713604018155 active site 713604018156 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604018157 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 713604018158 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604018159 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604018160 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604018161 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604018162 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 713604018163 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 713604018164 FAD binding pocket [chemical binding]; other site 713604018165 FAD binding motif [chemical binding]; other site 713604018166 phosphate binding motif [ion binding]; other site 713604018167 NAD binding pocket [chemical binding]; other site 713604018168 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604018169 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604018170 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018171 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604018172 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604018173 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604018174 putative NAD(P) binding site [chemical binding]; other site 713604018175 coproporphyrinogen III oxidase; Validated; Region: PRK05628 713604018176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604018177 FeS/SAM binding site; other site 713604018178 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 713604018179 putative dimer interface [polypeptide binding]; other site 713604018180 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604018181 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 713604018182 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713604018183 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713604018184 60S ribosomal protein L37a; Provisional; Region: PTZ00255; cl00875 713604018185 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 713604018186 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 713604018187 Active Sites [active] 713604018188 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 713604018189 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 713604018190 Active Sites [active] 713604018191 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 713604018192 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 713604018193 CysD dimerization site [polypeptide binding]; other site 713604018194 G1 box; other site 713604018195 putative GEF interaction site [polypeptide binding]; other site 713604018196 GTP/Mg2+ binding site [chemical binding]; other site 713604018197 Switch I region; other site 713604018198 G2 box; other site 713604018199 G3 box; other site 713604018200 Switch II region; other site 713604018201 G4 box; other site 713604018202 G5 box; other site 713604018203 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 713604018204 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 713604018205 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 713604018206 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 713604018207 putative active site [active] 713604018208 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 713604018209 active site 713604018210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018211 Mg2+ binding site [ion binding]; other site 713604018212 G-X-G motif; other site 713604018213 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 713604018214 enoyl-CoA hydratase; Provisional; Region: PRK07827 713604018215 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604018216 substrate binding site [chemical binding]; other site 713604018217 oxyanion hole (OAH) forming residues; other site 713604018218 trimer interface [polypeptide binding]; other site 713604018219 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 713604018220 putative RNAase interaction site [polypeptide binding]; other site 713604018221 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 713604018222 active site 713604018223 barstar interaction site; other site 713604018224 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604018225 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604018226 NAD(P) binding site [chemical binding]; other site 713604018227 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604018228 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604018229 amino acid transporter; Region: 2A0306; TIGR00909 713604018230 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 713604018231 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 713604018232 Nitronate monooxygenase; Region: NMO; pfam03060 713604018233 FMN binding site [chemical binding]; other site 713604018234 substrate binding site [chemical binding]; other site 713604018235 putative catalytic residue [active] 713604018236 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604018237 MarR family; Region: MarR_2; pfam12802 713604018238 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 713604018239 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 713604018240 active site 713604018241 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 713604018242 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604018243 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 713604018244 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604018245 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 713604018246 putative active site [active] 713604018247 GTP-binding protein LepA; Provisional; Region: PRK05433 713604018248 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 713604018249 G1 box; other site 713604018250 putative GEF interaction site [polypeptide binding]; other site 713604018251 GTP/Mg2+ binding site [chemical binding]; other site 713604018252 Switch I region; other site 713604018253 G2 box; other site 713604018254 G3 box; other site 713604018255 Switch II region; other site 713604018256 G4 box; other site 713604018257 G5 box; other site 713604018258 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 713604018259 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 713604018260 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 713604018261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604018262 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604018263 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604018264 active site 713604018265 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 713604018266 EamA-like transporter family; Region: EamA; pfam00892 713604018267 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 713604018268 hypothetical protein; Reviewed; Region: PRK07914 713604018269 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 713604018270 threonine synthase; Validated; Region: PRK07591 713604018271 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 713604018272 homodimer interface [polypeptide binding]; other site 713604018273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604018274 catalytic residue [active] 713604018275 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 713604018276 Competence protein; Region: Competence; pfam03772 713604018277 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604018278 SLBB domain; Region: SLBB; pfam10531 713604018279 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 713604018280 EDD domain protein, DegV family; Region: DegV; TIGR00762 713604018281 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 713604018282 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604018283 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604018284 catalytic core [active] 713604018285 Oligomerisation domain; Region: Oligomerisation; cl00519 713604018286 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 713604018287 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 713604018288 active site 713604018289 (T/H)XGH motif; other site 713604018290 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 713604018291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604018292 ATP binding site [chemical binding]; other site 713604018293 putative Mg++ binding site [ion binding]; other site 713604018294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604018295 nucleotide binding region [chemical binding]; other site 713604018296 ATP-binding site [chemical binding]; other site 713604018297 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604018298 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 713604018299 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 713604018300 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 713604018301 active site 713604018302 HIGH motif; other site 713604018303 KMSK motif region; other site 713604018304 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 713604018305 tRNA binding surface [nucleotide binding]; other site 713604018306 anticodon binding site; other site 713604018307 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604018308 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 713604018309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604018310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604018312 short chain dehydrogenase; Provisional; Region: PRK07041 713604018313 NAD(P) binding site [chemical binding]; other site 713604018314 active site 713604018315 gamma-glutamyl kinase; Provisional; Region: PRK05429 713604018316 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 713604018317 nucleotide binding site [chemical binding]; other site 713604018318 homotetrameric interface [polypeptide binding]; other site 713604018319 putative phosphate binding site [ion binding]; other site 713604018320 putative allosteric binding site; other site 713604018321 PUA domain; Region: PUA; pfam01472 713604018322 GTPase CgtA; Reviewed; Region: obgE; PRK12296 713604018323 GTP1/OBG; Region: GTP1_OBG; pfam01018 713604018324 Obg GTPase; Region: Obg; cd01898 713604018325 G1 box; other site 713604018326 GTP/Mg2+ binding site [chemical binding]; other site 713604018327 Switch I region; other site 713604018328 G2 box; other site 713604018329 G3 box; other site 713604018330 Switch II region; other site 713604018331 G4 box; other site 713604018332 G5 box; other site 713604018333 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 713604018334 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 713604018335 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 713604018336 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 713604018337 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 713604018338 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 713604018339 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 713604018340 homodimer interface [polypeptide binding]; other site 713604018341 oligonucleotide binding site [chemical binding]; other site 713604018342 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 713604018343 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604018344 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604018345 active site 713604018346 catalytic residues [active] 713604018347 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604018348 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604018349 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604018350 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604018351 nodulation ABC transporter NodI; Provisional; Region: PRK13537 713604018352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604018353 Walker A/P-loop; other site 713604018354 ATP binding site [chemical binding]; other site 713604018355 Q-loop/lid; other site 713604018356 ABC transporter signature motif; other site 713604018357 Walker B; other site 713604018358 D-loop; other site 713604018359 H-loop/switch region; other site 713604018360 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 713604018361 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604018362 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604018363 active site 713604018364 metal binding site [ion binding]; metal-binding site 713604018365 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604018366 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604018367 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 713604018368 active site 713604018369 multimer interface [polypeptide binding]; other site 713604018370 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 713604018371 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 713604018372 putative active site [active] 713604018373 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604018374 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604018375 Penicillin amidase; Region: Penicil_amidase; pfam01804 713604018376 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604018377 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604018378 active site 713604018379 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 713604018380 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 713604018381 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 713604018382 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 713604018383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604018384 S-adenosylmethionine binding site [chemical binding]; other site 713604018385 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 713604018386 active site 713604018387 catalytic triad [active] 713604018388 oxyanion hole [active] 713604018389 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604018390 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604018391 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604018392 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 713604018393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604018394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604018395 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604018396 dimerization interface [polypeptide binding]; other site 713604018397 substrate binding pocket [chemical binding]; other site 713604018398 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 713604018399 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 713604018400 HIGH motif; other site 713604018401 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 713604018402 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 713604018403 active site 713604018404 KMSKS motif; other site 713604018405 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 713604018406 tRNA binding surface [nucleotide binding]; other site 713604018407 anticodon binding site; other site 713604018408 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 713604018409 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604018410 MarR family; Region: MarR; pfam01047 713604018411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604018412 putative substrate translocation pore; other site 713604018413 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 713604018414 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 713604018415 putative molybdopterin cofactor binding site [chemical binding]; other site 713604018416 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 713604018417 putative molybdopterin cofactor binding site; other site 713604018418 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604018419 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 713604018420 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 713604018421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604018422 putative substrate translocation pore; other site 713604018423 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 713604018424 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 713604018425 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 713604018426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604018427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018428 WHG domain; Region: WHG; pfam13305 713604018429 Putative esterase; Region: Esterase; pfam00756 713604018430 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 713604018431 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604018432 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 713604018433 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 713604018434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604018435 Walker A motif; other site 713604018436 ATP binding site [chemical binding]; other site 713604018437 Walker B motif; other site 713604018438 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 713604018439 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 713604018440 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 713604018441 oligomer interface [polypeptide binding]; other site 713604018442 active site residues [active] 713604018443 Clp protease; Region: CLP_protease; pfam00574 713604018444 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 713604018445 oligomer interface [polypeptide binding]; other site 713604018446 active site residues [active] 713604018447 trigger factor; Provisional; Region: tig; PRK01490 713604018448 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 713604018449 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 713604018450 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604018451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018452 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604018453 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 713604018454 putative di-iron ligands [ion binding]; other site 713604018455 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 713604018456 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 713604018457 FAD binding pocket [chemical binding]; other site 713604018458 FAD binding motif [chemical binding]; other site 713604018459 phosphate binding motif [ion binding]; other site 713604018460 beta-alpha-beta structure motif; other site 713604018461 NAD(p) ribose binding residues [chemical binding]; other site 713604018462 NAD binding pocket [chemical binding]; other site 713604018463 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 713604018464 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604018465 catalytic loop [active] 713604018466 iron binding site [ion binding]; other site 713604018467 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 713604018468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604018469 dimer interface [polypeptide binding]; other site 713604018470 phosphorylation site [posttranslational modification] 713604018471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018472 ATP binding site [chemical binding]; other site 713604018473 Mg2+ binding site [ion binding]; other site 713604018474 G-X-G motif; other site 713604018475 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 713604018476 thiamine monophosphate kinase; Provisional; Region: PRK05731 713604018477 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 713604018478 ATP binding site [chemical binding]; other site 713604018479 dimerization interface [polypeptide binding]; other site 713604018480 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 713604018481 trimer interface [polypeptide binding]; other site 713604018482 active site 713604018483 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604018484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604018485 non-specific DNA binding site [nucleotide binding]; other site 713604018486 salt bridge; other site 713604018487 sequence-specific DNA binding site [nucleotide binding]; other site 713604018488 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604018489 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604018490 ligand binding site [chemical binding]; other site 713604018491 flexible hinge region; other site 713604018492 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 713604018493 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604018494 active site 713604018495 Predicted membrane protein [Function unknown]; Region: COG2246 713604018496 GtrA-like protein; Region: GtrA; pfam04138 713604018497 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 713604018498 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604018499 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604018500 DNA binding site [nucleotide binding] 713604018501 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604018502 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 713604018503 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 713604018504 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604018505 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604018506 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 713604018507 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604018508 active site 713604018509 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 713604018510 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 713604018511 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604018512 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604018513 Walker A/P-loop; other site 713604018514 ATP binding site [chemical binding]; other site 713604018515 Q-loop/lid; other site 713604018516 ABC transporter signature motif; other site 713604018517 Walker B; other site 713604018518 D-loop; other site 713604018519 H-loop/switch region; other site 713604018520 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 713604018521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018522 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604018523 active site 713604018524 catalytic residues [active] 713604018525 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604018526 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 713604018527 non-specific DNA interactions [nucleotide binding]; other site 713604018528 DNA binding site [nucleotide binding] 713604018529 sequence specific DNA binding site [nucleotide binding]; other site 713604018530 putative cAMP binding site [chemical binding]; other site 713604018531 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604018532 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604018533 xylose isomerase; Provisional; Region: PRK12677 713604018534 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 713604018535 Trehalose utilisation; Region: ThuA; pfam06283 713604018536 MarR family; Region: MarR; pfam01047 713604018537 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 713604018538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604018539 putative substrate translocation pore; other site 713604018540 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604018541 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604018542 active site 713604018543 catalytic tetrad [active] 713604018544 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604018545 Ycf48-like protein; Provisional; Region: PRK13684 713604018546 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604018547 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 713604018548 intracellular protease, PfpI family; Region: PfpI; TIGR01382 713604018549 proposed catalytic triad [active] 713604018550 conserved cys residue [active] 713604018551 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604018552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018553 dimerization interface [polypeptide binding]; other site 713604018554 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 713604018555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018556 dimerization interface [polypeptide binding]; other site 713604018557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018558 dimerization interface [polypeptide binding]; other site 713604018559 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018560 dimerization interface [polypeptide binding]; other site 713604018561 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 713604018562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018563 dimerization interface [polypeptide binding]; other site 713604018564 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018565 dimerization interface [polypeptide binding]; other site 713604018566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018567 dimerization interface [polypeptide binding]; other site 713604018568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018569 dimerization interface [polypeptide binding]; other site 713604018570 GAF domain; Region: GAF_2; pfam13185 713604018571 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 713604018572 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604018573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604018574 dimer interface [polypeptide binding]; other site 713604018575 phosphorylation site [posttranslational modification] 713604018576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018577 ATP binding site [chemical binding]; other site 713604018578 Mg2+ binding site [ion binding]; other site 713604018579 G-X-G motif; other site 713604018580 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 713604018581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018582 active site 713604018583 phosphorylation site [posttranslational modification] 713604018584 intermolecular recognition site; other site 713604018585 dimerization interface [polypeptide binding]; other site 713604018586 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 713604018587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604018588 S-adenosylmethionine binding site [chemical binding]; other site 713604018589 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 713604018590 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604018591 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604018592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604018593 non-specific DNA binding site [nucleotide binding]; other site 713604018594 salt bridge; other site 713604018595 sequence-specific DNA binding site [nucleotide binding]; other site 713604018596 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 713604018597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 713604018598 motif II; other site 713604018599 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 713604018600 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604018601 putative NAD(P) binding site [chemical binding]; other site 713604018602 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 713604018603 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 713604018604 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 713604018605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604018606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604018607 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604018608 dimerization interface [polypeptide binding]; other site 713604018609 substrate binding pocket [chemical binding]; other site 713604018610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604018611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018612 short chain dehydrogenase; Provisional; Region: PRK06500 713604018613 classical (c) SDRs; Region: SDR_c; cd05233 713604018614 NAD(P) binding site [chemical binding]; other site 713604018615 active site 713604018616 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 713604018617 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 713604018618 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604018619 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604018620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604018621 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604018622 NAD(P) binding site [chemical binding]; other site 713604018623 active site 713604018624 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604018625 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604018626 alpha-galactosidase; Region: PLN02808; cl17638 713604018627 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 713604018628 Ca binding site [ion binding]; other site 713604018629 Ca binding site (active) [ion binding]; other site 713604018630 ligand binding site [chemical binding]; other site 713604018631 SnoaL-like domain; Region: SnoaL_2; pfam12680 713604018632 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604018633 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604018634 AAA domain; Region: AAA_27; pfam13514 713604018635 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604018636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018637 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 713604018638 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 713604018639 ring oligomerisation interface [polypeptide binding]; other site 713604018640 ATP/Mg binding site [chemical binding]; other site 713604018641 stacking interactions; other site 713604018642 hinge regions; other site 713604018643 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 713604018644 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 713604018645 putative DNA binding site [nucleotide binding]; other site 713604018646 catalytic residue [active] 713604018647 putative H2TH interface [polypeptide binding]; other site 713604018648 putative catalytic residues [active] 713604018649 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604018650 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 713604018651 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 713604018652 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604018653 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 713604018654 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 713604018655 catalytic residues [active] 713604018656 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 713604018657 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 713604018658 Zn binding site [ion binding]; other site 713604018659 Repair protein; Region: Repair_PSII; pfam04536 713604018660 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 713604018661 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604018662 active site 713604018663 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 713604018664 Mechanosensitive ion channel; Region: MS_channel; pfam00924 713604018665 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 713604018666 apolar tunnel; other site 713604018667 heme binding site [chemical binding]; other site 713604018668 dimerization interface [polypeptide binding]; other site 713604018669 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 713604018670 active site 713604018671 catalytic site [active] 713604018672 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 713604018673 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 713604018674 active site 713604018675 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 713604018676 transcription termination factor Rho; Provisional; Region: PRK12678 713604018677 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 713604018678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604018679 Walker A/P-loop; other site 713604018680 ATP binding site [chemical binding]; other site 713604018681 Q-loop/lid; other site 713604018682 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604018683 ABC transporter; Region: ABC_tran_2; pfam12848 713604018684 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604018685 Copper resistance protein D; Region: CopD; pfam05425 713604018686 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 713604018687 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604018688 catalytic core [active] 713604018689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604018690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018691 ATP binding site [chemical binding]; other site 713604018692 Mg2+ binding site [ion binding]; other site 713604018693 G-X-G motif; other site 713604018694 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 713604018695 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604018696 inhibitor-cofactor binding pocket; inhibition site 713604018697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604018698 catalytic residue [active] 713604018699 choline dehydrogenase; Validated; Region: PRK02106 713604018700 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604018701 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 713604018702 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 713604018703 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604018704 active site 713604018705 choline dehydrogenase; Validated; Region: PRK02106 713604018706 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604018707 conserved hypothetical protein; Region: TIGR02246 713604018708 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604018709 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 713604018710 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 713604018711 dimer interface [polypeptide binding]; other site 713604018712 catalytic triad [active] 713604018713 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604018714 conserved hypothetical protein; Region: TIGR02246 713604018715 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 713604018716 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 713604018717 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604018718 NAD binding site [chemical binding]; other site 713604018719 catalytic residues [active] 713604018720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604018721 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604018722 putative substrate translocation pore; other site 713604018723 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604018724 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604018725 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604018726 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604018727 active site 713604018728 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604018729 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604018730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604018731 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 713604018732 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 713604018733 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604018734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604018735 NAD(P) binding site [chemical binding]; other site 713604018736 active site 713604018737 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 713604018738 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 713604018739 active site 713604018740 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 713604018741 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 713604018742 active site 713604018743 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 713604018744 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 713604018745 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 713604018746 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 713604018747 putative NADP binding site [chemical binding]; other site 713604018748 active site 713604018749 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 713604018750 TIGR03084 family protein; Region: TIGR03084 713604018751 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604018752 Wyosine base formation; Region: Wyosine_form; pfam08608 713604018753 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 713604018754 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 713604018755 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604018756 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 713604018757 Cytochrome P450; Region: p450; pfam00067 713604018758 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604018759 Family description; Region: VCBS; pfam13517 713604018760 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 713604018761 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 713604018762 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 713604018763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604018764 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604018765 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604018766 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604018767 DNA binding site [nucleotide binding] 713604018768 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604018769 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604018770 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604018771 SCP-2 sterol transfer family; Region: SCP2; cl01225 713604018772 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604018773 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604018774 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604018775 YCII-related domain; Region: YCII; cl00999 713604018776 TIGR03084 family protein; Region: TIGR03084 713604018777 Wyosine base formation; Region: Wyosine_form; pfam08608 713604018778 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 713604018779 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 713604018780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604018781 Histidine kinase; Region: HisKA_3; pfam07730 713604018782 Histidine kinase; Region: HisKA_3; pfam07730 713604018783 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604018784 ATP binding site [chemical binding]; other site 713604018785 Mg2+ binding site [ion binding]; other site 713604018786 G-X-G motif; other site 713604018787 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604018788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018789 active site 713604018790 phosphorylation site [posttranslational modification] 713604018791 intermolecular recognition site; other site 713604018792 dimerization interface [polypeptide binding]; other site 713604018793 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604018794 DNA binding residues [nucleotide binding] 713604018795 dimerization interface [polypeptide binding]; other site 713604018796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604018797 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604018798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604018799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604018800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018801 active site 713604018802 phosphorylation site [posttranslational modification] 713604018803 intermolecular recognition site; other site 713604018804 dimerization interface [polypeptide binding]; other site 713604018805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604018806 DNA binding residues [nucleotide binding] 713604018807 dimerization interface [polypeptide binding]; other site 713604018808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604018809 Histidine kinase; Region: HisKA_3; pfam07730 713604018810 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 713604018811 NADPH bind site [chemical binding]; other site 713604018812 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 713604018813 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 713604018814 YcaO-like family; Region: YcaO; pfam02624 713604018815 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604018816 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604018817 CopC domain; Region: CopC; pfam04234 713604018818 Copper resistance protein D; Region: CopD; cl00563 713604018819 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604018820 CAAX protease self-immunity; Region: Abi; pfam02517 713604018821 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 713604018822 putative homotetramer interface [polypeptide binding]; other site 713604018823 putative homodimer interface [polypeptide binding]; other site 713604018824 putative allosteric switch controlling residues; other site 713604018825 putative metal binding site [ion binding]; other site 713604018826 putative homodimer-homodimer interface [polypeptide binding]; other site 713604018827 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 713604018828 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604018829 metal-binding site [ion binding] 713604018830 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 713604018831 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 713604018832 metal-binding site [ion binding] 713604018833 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 713604018834 active site 713604018835 SAM binding site [chemical binding]; other site 713604018836 homodimer interface [polypeptide binding]; other site 713604018837 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604018838 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604018839 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 713604018840 malonic semialdehyde reductase; Provisional; Region: PRK10538 713604018841 putative NAD(P) binding site [chemical binding]; other site 713604018842 homotetramer interface [polypeptide binding]; other site 713604018843 homodimer interface [polypeptide binding]; other site 713604018844 active site 713604018845 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 713604018846 FO synthase; Reviewed; Region: fbiC; PRK09234 713604018847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604018848 FeS/SAM binding site; other site 713604018849 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604018850 FeS/SAM binding site; other site 713604018851 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 713604018852 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 713604018853 Probable molybdopterin binding domain; Region: MoCF_biosynth; smart00852 713604018854 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 713604018855 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604018856 Methyltransferase domain; Region: Methyltransf_11; pfam08241 713604018857 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604018858 putative metal binding site [ion binding]; other site 713604018859 Right handed beta helix region; Region: Beta_helix; pfam13229 713604018860 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604018861 sugar binding site [chemical binding]; other site 713604018862 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 713604018863 putative metal binding site [ion binding]; other site 713604018864 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 713604018865 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604018866 sugar binding site [chemical binding]; other site 713604018867 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604018868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018869 active site 713604018870 phosphorylation site [posttranslational modification] 713604018871 intermolecular recognition site; other site 713604018872 dimerization interface [polypeptide binding]; other site 713604018873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604018874 DNA binding site [nucleotide binding] 713604018875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604018876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604018877 dimerization interface [polypeptide binding]; other site 713604018878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604018879 dimer interface [polypeptide binding]; other site 713604018880 phosphorylation site [posttranslational modification] 713604018881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018882 ATP binding site [chemical binding]; other site 713604018883 Mg2+ binding site [ion binding]; other site 713604018884 G-X-G motif; other site 713604018885 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604018886 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604018887 DNA binding site [nucleotide binding] 713604018888 domain linker motif; other site 713604018889 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 713604018890 putative dimerization interface [polypeptide binding]; other site 713604018891 putative ligand binding site [chemical binding]; other site 713604018892 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604018893 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604018894 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604018895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604018896 dimer interface [polypeptide binding]; other site 713604018897 conserved gate region; other site 713604018898 putative PBP binding loops; other site 713604018899 ABC-ATPase subunit interface; other site 713604018900 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604018901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604018902 dimer interface [polypeptide binding]; other site 713604018903 conserved gate region; other site 713604018904 putative PBP binding loops; other site 713604018905 ABC-ATPase subunit interface; other site 713604018906 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 713604018907 active site 713604018908 catalytic site [active] 713604018909 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 713604018910 AAA ATPase domain; Region: AAA_16; pfam13191 713604018911 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604018912 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 713604018913 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 713604018914 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 713604018915 Ligand Binding Site [chemical binding]; other site 713604018916 Molecular Tunnel; other site 713604018917 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604018918 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604018919 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604018920 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 713604018921 Uncharacterized conserved protein [Function unknown]; Region: COG5276 713604018922 Uncharacterized conserved protein [Function unknown]; Region: COG5276 713604018923 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 713604018924 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 713604018925 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604018926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604018927 LysR substrate binding domain; Region: LysR_substrate; pfam03466 713604018928 dimerization interface [polypeptide binding]; other site 713604018929 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604018930 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 713604018931 NAD(P) binding site [chemical binding]; other site 713604018932 active site 713604018933 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 713604018934 classical (c) SDRs; Region: SDR_c; cd05233 713604018935 NAD(P) binding site [chemical binding]; other site 713604018936 active site 713604018937 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 713604018938 putative active site [active] 713604018939 putative catalytic triad [active] 713604018940 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604018941 catalytic residues [active] 713604018942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604018943 Coenzyme A binding pocket [chemical binding]; other site 713604018944 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 713604018945 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604018946 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 713604018947 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 713604018948 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 713604018949 putative acyl-acceptor binding pocket; other site 713604018950 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604018951 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604018952 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604018953 DNA binding site [nucleotide binding] 713604018954 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604018955 dimerization interface [polypeptide binding]; other site 713604018956 ligand binding site [chemical binding]; other site 713604018957 Protein of unknown function (DUF993); Region: DUF993; pfam06187 713604018958 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604018959 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604018960 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 713604018961 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604018962 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604018963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604018964 active site 713604018965 phosphorylation site [posttranslational modification] 713604018966 intermolecular recognition site; other site 713604018967 dimerization interface [polypeptide binding]; other site 713604018968 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604018969 DNA binding site [nucleotide binding] 713604018970 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604018971 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604018972 dimer interface [polypeptide binding]; other site 713604018973 phosphorylation site [posttranslational modification] 713604018974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604018975 ATP binding site [chemical binding]; other site 713604018976 Mg2+ binding site [ion binding]; other site 713604018977 G-X-G motif; other site 713604018978 amino acid transporter; Region: 2A0306; TIGR00909 713604018979 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 713604018980 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 713604018981 Predicted amidohydrolase [General function prediction only]; Region: COG0388 713604018982 putative active site [active] 713604018983 catalytic triad [active] 713604018984 putative dimer interface [polypeptide binding]; other site 713604018985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604018986 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 713604018987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604018988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604018990 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604018991 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604018992 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604018993 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604018994 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 713604018995 active site 713604018996 catalytic triad [active] 713604018997 oxyanion hole [active] 713604018998 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604018999 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 713604019000 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604019001 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 713604019002 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604019003 active site 713604019004 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019005 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604019006 acyl-activating enzyme (AAE) consensus motif; other site 713604019007 AMP binding site [chemical binding]; other site 713604019008 active site 713604019009 CoA binding site [chemical binding]; other site 713604019010 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 713604019011 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 713604019012 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604019013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604019014 dimerization interface [polypeptide binding]; other site 713604019015 putative DNA binding site [nucleotide binding]; other site 713604019016 putative Zn2+ binding site [ion binding]; other site 713604019017 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604019018 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604019019 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604019020 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 713604019021 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604019022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604019023 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604019024 dimerization interface [polypeptide binding]; other site 713604019025 substrate binding pocket [chemical binding]; other site 713604019026 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 713604019027 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 713604019028 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 713604019029 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 713604019030 NAD binding site [chemical binding]; other site 713604019031 Phe binding site; other site 713604019032 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 713604019033 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604019034 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 713604019035 PaaX-like protein; Region: PaaX; pfam07848 713604019036 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 713604019037 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 713604019038 Creatinine amidohydrolase; Region: Creatininase; pfam02633 713604019039 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019040 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 713604019041 acyl-activating enzyme (AAE) consensus motif; other site 713604019042 AMP binding site [chemical binding]; other site 713604019043 active site 713604019044 CoA binding site [chemical binding]; other site 713604019045 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604019046 classical (c) SDRs; Region: SDR_c; cd05233 713604019047 NAD(P) binding site [chemical binding]; other site 713604019048 active site 713604019049 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604019050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019051 substrate binding site [chemical binding]; other site 713604019052 oxyanion hole (OAH) forming residues; other site 713604019053 trimer interface [polypeptide binding]; other site 713604019054 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 713604019055 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 713604019056 active site 713604019057 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604019058 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604019059 active site 713604019060 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 713604019061 Strictosidine synthase; Region: Str_synth; pfam03088 713604019062 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604019063 catalytic core [active] 713604019064 Phosphotransferase enzyme family; Region: APH; pfam01636 713604019065 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 713604019066 putative active site [active] 713604019067 putative substrate binding site [chemical binding]; other site 713604019068 ATP binding site [chemical binding]; other site 713604019069 short chain dehydrogenase; Provisional; Region: PRK08251 713604019070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019071 NAD(P) binding site [chemical binding]; other site 713604019072 active site 713604019073 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 713604019074 cyclase homology domain; Region: CHD; cd07302 713604019075 AAA ATPase domain; Region: AAA_16; pfam13191 713604019076 Predicted ATPase [General function prediction only]; Region: COG3903 713604019077 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604019078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604019079 DNA binding residues [nucleotide binding] 713604019080 dimerization interface [polypeptide binding]; other site 713604019081 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604019082 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604019083 acyl-CoA synthetase; Validated; Region: PRK07788 713604019084 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019085 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604019086 acyl-activating enzyme (AAE) consensus motif; other site 713604019087 putative AMP binding site [chemical binding]; other site 713604019088 putative active site [active] 713604019089 putative CoA binding site [chemical binding]; other site 713604019090 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 713604019091 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 713604019092 active site 713604019093 DNA binding site [nucleotide binding] 713604019094 catalytic site [active] 713604019095 BNR repeat-like domain; Region: BNR_2; pfam13088 713604019096 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 713604019097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604019098 ATP binding site [chemical binding]; other site 713604019099 putative Mg++ binding site [ion binding]; other site 713604019100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604019101 nucleotide binding region [chemical binding]; other site 713604019102 ATP-binding site [chemical binding]; other site 713604019103 Helicase associated domain (HA2); Region: HA2; pfam04408 713604019104 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 713604019105 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 713604019106 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 713604019107 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 713604019108 putative active site [active] 713604019109 putative substrate binding site [chemical binding]; other site 713604019110 putative FMN binding site [chemical binding]; other site 713604019111 putative catalytic residues [active] 713604019112 Uncharacterized conserved protein [Function unknown]; Region: COG3268 713604019113 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604019114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604019115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019116 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 713604019117 chitosan binding site [chemical binding]; other site 713604019118 catalytic residues [active] 713604019119 hypothetical protein; Provisional; Region: PRK07945 713604019120 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 713604019121 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 713604019122 active site 713604019123 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 713604019124 active site 713604019125 metal binding site [ion binding]; metal-binding site 713604019126 homotetramer interface [polypeptide binding]; other site 713604019127 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604019128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019129 DNA-binding site [nucleotide binding]; DNA binding site 713604019130 FCD domain; Region: FCD; pfam07729 713604019131 dihydroxy-acid dehydratase; Validated; Region: PRK06131 713604019132 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 713604019133 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 713604019134 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 713604019135 VanW like protein; Region: VanW; pfam04294 713604019136 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604019137 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604019138 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604019139 metal binding site [ion binding]; metal-binding site 713604019140 active site 713604019141 I-site; other site 713604019142 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 713604019143 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 713604019144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604019145 catalytic residue [active] 713604019146 Dienelactone hydrolase family; Region: DLH; pfam01738 713604019147 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604019148 YCII-related domain; Region: YCII; cl00999 713604019149 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 713604019150 rRNA binding site [nucleotide binding]; other site 713604019151 predicted 30S ribosome binding site; other site 713604019152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604019153 Coenzyme A binding pocket [chemical binding]; other site 713604019154 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019155 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604019156 active site 713604019157 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019158 active site 713604019159 metal binding site [ion binding]; metal-binding site 713604019160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019161 DNA-binding site [nucleotide binding]; DNA binding site 713604019162 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604019163 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604019164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604019165 homodimer interface [polypeptide binding]; other site 713604019166 catalytic residue [active] 713604019167 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 713604019168 H2TH interface [polypeptide binding]; other site 713604019169 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 713604019170 DNA binding site [nucleotide binding] 713604019171 putative catalytic residues [active] 713604019172 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604019173 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 713604019174 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 713604019175 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 713604019176 Cytochrome P450; Region: p450; cl12078 713604019177 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019178 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604019179 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604019180 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019181 Cytochrome P450; Region: p450; cl12078 713604019182 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604019183 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 713604019184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604019185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019186 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604019187 FAD binding domain; Region: FAD_binding_4; pfam01565 713604019188 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 713604019189 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 713604019190 GAF domain; Region: GAF; pfam01590 713604019191 Histidine kinase; Region: HisKA_3; pfam07730 713604019192 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604019193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604019194 active site 713604019195 phosphorylation site [posttranslational modification] 713604019196 intermolecular recognition site; other site 713604019197 dimerization interface [polypeptide binding]; other site 713604019198 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604019199 DNA binding residues [nucleotide binding] 713604019200 dimerization interface [polypeptide binding]; other site 713604019201 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 713604019202 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 713604019203 active site 713604019204 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 713604019205 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 713604019206 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 713604019207 Walker A/P-loop; other site 713604019208 ATP binding site [chemical binding]; other site 713604019209 Q-loop/lid; other site 713604019210 ABC transporter signature motif; other site 713604019211 Walker B; other site 713604019212 D-loop; other site 713604019213 H-loop/switch region; other site 713604019214 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604019215 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 713604019216 Walker A/P-loop; other site 713604019217 ATP binding site [chemical binding]; other site 713604019218 Q-loop/lid; other site 713604019219 ABC transporter signature motif; other site 713604019220 Walker B; other site 713604019221 D-loop; other site 713604019222 H-loop/switch region; other site 713604019223 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 713604019224 TM-ABC transporter signature motif; other site 713604019225 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 713604019226 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 713604019227 TM-ABC transporter signature motif; other site 713604019228 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 713604019229 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 713604019230 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604019231 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604019232 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604019233 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604019234 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604019235 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 713604019236 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604019237 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 713604019238 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 713604019239 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 713604019240 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 713604019241 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 713604019242 active site 713604019243 dimer interface [polypeptide binding]; other site 713604019244 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 713604019245 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 713604019246 active site 713604019247 FMN binding site [chemical binding]; other site 713604019248 substrate binding site [chemical binding]; other site 713604019249 3Fe-4S cluster binding site [ion binding]; other site 713604019250 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 713604019251 domain interface; other site 713604019252 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 713604019253 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 713604019254 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 713604019255 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604019256 putative NAD(P) binding site [chemical binding]; other site 713604019257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604019258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019259 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 713604019260 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604019261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604019262 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 713604019263 cobyric acid synthase; Provisional; Region: PRK00784 713604019264 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 713604019265 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 713604019266 catalytic triad [active] 713604019267 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 713604019268 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 713604019269 homotrimer interface [polypeptide binding]; other site 713604019270 Walker A motif; other site 713604019271 GTP binding site [chemical binding]; other site 713604019272 Walker B motif; other site 713604019273 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 713604019274 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 713604019275 putative dimer interface [polypeptide binding]; other site 713604019276 active site pocket [active] 713604019277 putative cataytic base [active] 713604019278 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 713604019279 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604019280 HTH domain; Region: HTH_11; pfam08279 713604019281 WYL domain; Region: WYL; pfam13280 713604019282 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 713604019283 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604019284 hypothetical protein; Provisional; Region: PRK07908 713604019285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604019286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604019287 homodimer interface [polypeptide binding]; other site 713604019288 catalytic residue [active] 713604019289 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 713604019290 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 713604019291 catalytic triad [active] 713604019292 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 713604019293 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 713604019294 homodimer interface [polypeptide binding]; other site 713604019295 Walker A motif; other site 713604019296 ATP binding site [chemical binding]; other site 713604019297 hydroxycobalamin binding site [chemical binding]; other site 713604019298 Walker B motif; other site 713604019299 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 713604019300 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 713604019301 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 713604019302 metal ion-dependent adhesion site (MIDAS); other site 713604019303 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 713604019304 active site 713604019305 putative homodimer interface [polypeptide binding]; other site 713604019306 SAM binding site [chemical binding]; other site 713604019307 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 713604019308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604019309 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 713604019310 active site 713604019311 homodimer interface [polypeptide binding]; other site 713604019312 SAM binding site [chemical binding]; other site 713604019313 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604019314 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604019315 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604019316 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 713604019317 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 713604019318 putative FMN binding site [chemical binding]; other site 713604019319 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 713604019320 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 713604019321 active site 713604019322 SAM binding site [chemical binding]; other site 713604019323 homodimer interface [polypeptide binding]; other site 713604019324 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 713604019325 homodimer interface [polypeptide binding]; other site 713604019326 active site 713604019327 SAM binding site [chemical binding]; other site 713604019328 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 713604019329 Precorrin-8X methylmutase; Region: CbiC; pfam02570 713604019330 precorrin-3B synthase; Region: CobG; TIGR02435 713604019331 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713604019332 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 713604019333 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604019334 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604019335 Walker A/P-loop; other site 713604019336 ATP binding site [chemical binding]; other site 713604019337 Q-loop/lid; other site 713604019338 ABC transporter signature motif; other site 713604019339 Walker B; other site 713604019340 D-loop; other site 713604019341 H-loop/switch region; other site 713604019342 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604019343 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604019344 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604019345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604019346 non-specific DNA binding site [nucleotide binding]; other site 713604019347 salt bridge; other site 713604019348 sequence-specific DNA binding site [nucleotide binding]; other site 713604019349 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 713604019350 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 713604019351 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 713604019352 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 713604019353 active site 713604019354 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 713604019355 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604019356 RibD C-terminal domain; Region: RibD_C; cl17279 713604019357 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 713604019358 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 713604019359 catalytic motif [active] 713604019360 Zn binding site [ion binding]; other site 713604019361 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 713604019362 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 713604019363 NAD(P) binding site [chemical binding]; other site 713604019364 catalytic residues [active] 713604019365 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 713604019366 DDE superfamily endonuclease; Region: DDE_5; pfam13546 713604019367 AlkA N-terminal domain; Region: AlkA_N; cl05528 713604019368 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 713604019369 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 713604019370 helix-hairpin-helix signature motif; other site 713604019371 active site 713604019372 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 713604019373 amidohydrolase; Region: amidohydrolases; TIGR01891 713604019374 metal binding site [ion binding]; metal-binding site 713604019375 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604019376 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 713604019377 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 713604019378 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 713604019379 putative active site [active] 713604019380 putative substrate binding site [chemical binding]; other site 713604019381 dimer interface [polypeptide binding]; other site 713604019382 catalytic site [active] 713604019383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604019384 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604019385 putative substrate translocation pore; other site 713604019386 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 713604019387 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 713604019388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 713604019389 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604019390 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 713604019391 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 713604019392 Int/Topo IB signature motif; other site 713604019393 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604019394 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 713604019395 DNA methylase; Region: N6_N4_Mtase; pfam01555 713604019396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 713604019397 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 713604019398 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 713604019399 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604019400 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 713604019401 Walker A motif; other site 713604019402 ATP binding site [chemical binding]; other site 713604019403 Walker B motif; other site 713604019404 hypothetical protein; Provisional; Region: PRK06847 713604019405 hypothetical protein; Provisional; Region: PRK07236 713604019406 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604019407 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604019408 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604019409 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604019410 Helix-turn-helix domain; Region: HTH_31; pfam13560 713604019411 Homeodomain-like domain; Region: HTH_23; pfam13384 713604019412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 713604019413 sequence-specific DNA binding site [nucleotide binding]; other site 713604019414 salt bridge; other site 713604019415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604019416 sequence-specific DNA binding site [nucleotide binding]; other site 713604019417 salt bridge; other site 713604019418 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604019419 nudix motif; other site 713604019420 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 713604019421 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019422 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019423 active site 713604019424 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604019425 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604019426 NAD(P) binding site [chemical binding]; other site 713604019427 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 713604019428 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 713604019429 tetramer interface [polypeptide binding]; other site 713604019430 TPP-binding site [chemical binding]; other site 713604019431 heterodimer interface [polypeptide binding]; other site 713604019432 phosphorylation loop region [posttranslational modification] 713604019433 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 713604019434 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 713604019435 alpha subunit interface [polypeptide binding]; other site 713604019436 TPP binding site [chemical binding]; other site 713604019437 heterodimer interface [polypeptide binding]; other site 713604019438 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604019439 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604019440 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019441 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604019442 acyl-activating enzyme (AAE) consensus motif; other site 713604019443 acyl-activating enzyme (AAE) consensus motif; other site 713604019444 putative AMP binding site [chemical binding]; other site 713604019445 putative active site [active] 713604019446 putative CoA binding site [chemical binding]; other site 713604019447 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604019448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019449 NAD(P) binding site [chemical binding]; other site 713604019450 active site 713604019451 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604019452 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019453 substrate binding site [chemical binding]; other site 713604019454 oxyanion hole (OAH) forming residues; other site 713604019455 trimer interface [polypeptide binding]; other site 713604019456 Putative cyclase; Region: Cyclase; pfam04199 713604019457 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604019458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604019459 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 713604019460 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 713604019461 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 713604019462 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 713604019463 active site 713604019464 non-prolyl cis peptide bond; other site 713604019465 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604019466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019467 DNA-binding site [nucleotide binding]; DNA binding site 713604019468 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604019469 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604019470 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 713604019471 NAD(P) binding site [chemical binding]; other site 713604019472 catalytic residues [active] 713604019473 catalytic residues [active] 713604019474 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604019475 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604019476 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604019477 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604019478 Putative cyclase; Region: Cyclase; pfam04199 713604019479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019480 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 713604019481 NAD(P) binding site [chemical binding]; other site 713604019482 active site 713604019483 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604019484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604019485 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019486 active site 713604019487 metal binding site [ion binding]; metal-binding site 713604019488 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019489 Cytochrome P450; Region: p450; cl12078 713604019490 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604019491 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604019492 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604019493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604019494 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604019495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019496 NAD(P) binding site [chemical binding]; other site 713604019497 active site 713604019498 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604019499 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604019500 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604019501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604019502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019504 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604019505 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604019506 putative NAD(P) binding site [chemical binding]; other site 713604019507 DoxX-like family; Region: DoxX_2; pfam13564 713604019508 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 713604019509 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 713604019510 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 713604019511 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604019512 NAD binding site [chemical binding]; other site 713604019513 substrate binding site [chemical binding]; other site 713604019514 putative active site [active] 713604019515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604019517 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 713604019518 Walker A/P-loop; other site 713604019519 ATP binding site [chemical binding]; other site 713604019520 Q-loop/lid; other site 713604019521 ABC transporter signature motif; other site 713604019522 Walker B; other site 713604019523 D-loop; other site 713604019524 H-loop/switch region; other site 713604019525 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604019526 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 713604019527 TM-ABC transporter signature motif; other site 713604019528 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 713604019529 TM-ABC transporter signature motif; other site 713604019530 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604019531 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 713604019532 Walker A/P-loop; other site 713604019533 ATP binding site [chemical binding]; other site 713604019534 Q-loop/lid; other site 713604019535 ABC transporter signature motif; other site 713604019536 Walker B; other site 713604019537 D-loop; other site 713604019538 H-loop/switch region; other site 713604019539 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 713604019540 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 713604019541 putative ligand binding site [chemical binding]; other site 713604019542 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604019543 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019544 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019545 active site 713604019546 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019547 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604019548 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 713604019549 active site 713604019550 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 713604019551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019552 NAD(P) binding site [chemical binding]; other site 713604019553 active site 713604019554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019555 DNA-binding site [nucleotide binding]; DNA binding site 713604019556 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604019557 FCD domain; Region: FCD; pfam07729 713604019558 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604019559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019560 DNA-binding site [nucleotide binding]; DNA binding site 713604019561 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604019562 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 713604019563 active site 713604019564 catalytic site [active] 713604019565 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604019566 active site 2 [active] 713604019567 active site 1 [active] 713604019568 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 713604019569 classical (c) SDRs; Region: SDR_c; cd05233 713604019570 NAD(P) binding site [chemical binding]; other site 713604019571 active site 713604019572 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604019573 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 713604019574 NAD(P) binding site [chemical binding]; other site 713604019575 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019576 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019577 active site 713604019578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019579 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 713604019580 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 713604019581 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604019582 active site 713604019583 metal binding site [ion binding]; metal-binding site 713604019584 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 713604019585 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019586 Cytochrome P450; Region: p450; cl12078 713604019587 enoyl-CoA hydratase; Provisional; Region: PRK08252 713604019588 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019589 substrate binding site [chemical binding]; other site 713604019590 oxyanion hole (OAH) forming residues; other site 713604019591 trimer interface [polypeptide binding]; other site 713604019592 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 713604019593 putative active site [active] 713604019594 putative substrate binding site [chemical binding]; other site 713604019595 ATP binding site [chemical binding]; other site 713604019596 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019597 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019598 active site 713604019599 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604019600 classical (c) SDRs; Region: SDR_c; cd05233 713604019601 NAD(P) binding site [chemical binding]; other site 713604019602 active site 713604019603 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 713604019604 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 713604019605 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604019606 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604019607 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604019608 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604019609 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 713604019610 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604019611 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 713604019612 classical (c) SDRs; Region: SDR_c; cd05233 713604019613 NAD(P) binding site [chemical binding]; other site 713604019614 active site 713604019615 Amidohydrolase; Region: Amidohydro_2; pfam04909 713604019616 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 713604019617 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 713604019618 thiolase; Provisional; Region: PRK06158 713604019619 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 713604019620 active site 713604019621 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 713604019622 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604019623 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604019624 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604019625 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604019626 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 713604019627 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019628 active site 713604019629 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019630 active site 713604019631 metal binding site [ion binding]; metal-binding site 713604019632 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 713604019633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019634 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019635 active site 713604019636 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 713604019637 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 713604019638 classical (c) SDRs; Region: SDR_c; cd05233 713604019639 NAD(P) binding site [chemical binding]; other site 713604019640 active site 713604019641 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604019642 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 713604019643 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604019644 dimer interface [polypeptide binding]; other site 713604019645 active site 713604019646 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604019647 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604019648 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019649 substrate binding site [chemical binding]; other site 713604019650 oxyanion hole (OAH) forming residues; other site 713604019651 trimer interface [polypeptide binding]; other site 713604019652 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604019653 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019654 active site 713604019655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019656 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604019657 NAD(P) binding site [chemical binding]; other site 713604019658 active site 713604019659 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604019660 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604019661 acyl-activating enzyme (AAE) consensus motif; other site 713604019662 putative AMP binding site [chemical binding]; other site 713604019663 putative active site [active] 713604019664 putative CoA binding site [chemical binding]; other site 713604019665 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019666 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604019667 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019668 acyl-activating enzyme (AAE) consensus motif; other site 713604019669 acyl-activating enzyme (AAE) consensus motif; other site 713604019670 AMP binding site [chemical binding]; other site 713604019671 active site 713604019672 CoA binding site [chemical binding]; other site 713604019673 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019674 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 713604019675 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 713604019676 acyl-activating enzyme (AAE) consensus motif; other site 713604019677 putative AMP binding site [chemical binding]; other site 713604019678 putative active site [active] 713604019679 putative CoA binding site [chemical binding]; other site 713604019680 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019681 substrate binding site [chemical binding]; other site 713604019682 oxyanion hole (OAH) forming residues; other site 713604019683 trimer interface [polypeptide binding]; other site 713604019684 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604019685 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 713604019686 dimer interface [polypeptide binding]; other site 713604019687 active site 713604019688 enoyl-CoA hydratase; Provisional; Region: PRK05864 713604019689 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019690 substrate binding site [chemical binding]; other site 713604019691 oxyanion hole (OAH) forming residues; other site 713604019692 trimer interface [polypeptide binding]; other site 713604019693 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604019694 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 713604019695 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604019696 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604019697 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 713604019698 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604019699 active site 713604019700 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604019701 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604019702 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 713604019703 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019704 substrate binding site [chemical binding]; other site 713604019705 oxyanion hole (OAH) forming residues; other site 713604019706 trimer interface [polypeptide binding]; other site 713604019707 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 713604019708 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 713604019709 dihydropteroate synthase; Region: DHPS; TIGR01496 713604019710 substrate binding pocket [chemical binding]; other site 713604019711 dimer interface [polypeptide binding]; other site 713604019712 inhibitor binding site; inhibition site 713604019713 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604019714 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604019715 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 713604019716 NAD binding site [chemical binding]; other site 713604019717 catalytic residues [active] 713604019718 Predicted acyl esterases [General function prediction only]; Region: COG2936 713604019719 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 713604019720 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019721 Cytochrome P450; Region: p450; cl12078 713604019722 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 713604019723 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604019724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604019725 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 713604019726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019727 NAD(P) binding site [chemical binding]; other site 713604019728 active site 713604019729 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604019730 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604019731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604019732 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 713604019733 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604019734 SnoaL-like domain; Region: SnoaL_4; pfam13577 713604019735 Isochorismatase family; Region: Isochorismatase; pfam00857 713604019736 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 713604019737 catalytic triad [active] 713604019738 conserved cis-peptide bond; other site 713604019739 enoyl-CoA hydratase; Provisional; Region: PRK06688 713604019740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604019741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019742 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604019743 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604019744 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 713604019745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604019746 Cytochrome P450; Region: p450; cl12078 713604019747 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019748 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 713604019749 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604019750 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604019751 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 713604019752 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604019753 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604019754 NAD(P) binding site [chemical binding]; other site 713604019755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604019756 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604019757 ATP binding site [chemical binding]; other site 713604019758 Mg2+ binding site [ion binding]; other site 713604019759 G-X-G motif; other site 713604019760 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604019761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604019762 active site 713604019763 phosphorylation site [posttranslational modification] 713604019764 intermolecular recognition site; other site 713604019765 dimerization interface [polypeptide binding]; other site 713604019766 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604019767 DNA binding residues [nucleotide binding] 713604019768 dimerization interface [polypeptide binding]; other site 713604019769 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019770 CoA binding site [chemical binding]; other site 713604019771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604019772 acyl-activating enzyme (AAE) consensus motif; other site 713604019773 active site 713604019774 AMP binding site [chemical binding]; other site 713604019775 CoA binding site [chemical binding]; other site 713604019776 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604019777 galactonate dehydratase; Provisional; Region: PRK14017 713604019778 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 713604019779 active site pocket [active] 713604019780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604019781 D-galactonate transporter; Region: 2A0114; TIGR00893 713604019782 putative substrate translocation pore; other site 713604019783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604019784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604019785 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 713604019786 dimerization interface [polypeptide binding]; other site 713604019787 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604019788 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604019789 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 713604019790 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604019791 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 713604019792 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604019793 NAD binding site [chemical binding]; other site 713604019794 substrate binding site [chemical binding]; other site 713604019795 putative active site [active] 713604019796 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604019797 aldolase II superfamily protein; Provisional; Region: PRK07044 713604019798 intersubunit interface [polypeptide binding]; other site 713604019799 active site 713604019800 Zn2+ binding site [ion binding]; other site 713604019801 metabolite-proton symporter; Region: 2A0106; TIGR00883 713604019802 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604019803 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 713604019804 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604019805 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 713604019806 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 713604019807 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 713604019808 Domain of unknown function (DUF336); Region: DUF336; cl01249 713604019809 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604019810 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604019811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604019812 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604019813 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604019814 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604019815 DNA binding site [nucleotide binding] 713604019816 domain linker motif; other site 713604019817 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604019818 dimerization interface [polypeptide binding]; other site 713604019819 ligand binding site [chemical binding]; other site 713604019820 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604019821 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604019822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604019823 dimer interface [polypeptide binding]; other site 713604019824 conserved gate region; other site 713604019825 putative PBP binding loops; other site 713604019826 ABC-ATPase subunit interface; other site 713604019827 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604019828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604019829 dimer interface [polypeptide binding]; other site 713604019830 conserved gate region; other site 713604019831 putative PBP binding loops; other site 713604019832 ABC-ATPase subunit interface; other site 713604019833 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 713604019834 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 713604019835 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604019836 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604019837 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604019838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019839 DNA-binding site [nucleotide binding]; DNA binding site 713604019840 FCD domain; Region: FCD; pfam07729 713604019841 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604019842 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604019843 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 713604019844 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 713604019845 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604019846 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604019847 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604019848 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 713604019849 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 713604019850 NAD binding site [chemical binding]; other site 713604019851 ligand binding site [chemical binding]; other site 713604019852 catalytic site [active] 713604019853 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 713604019854 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 713604019855 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 713604019856 enoyl-CoA hydratase; Provisional; Region: PRK06495 713604019857 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604019858 substrate binding site [chemical binding]; other site 713604019859 oxyanion hole (OAH) forming residues; other site 713604019860 trimer interface [polypeptide binding]; other site 713604019861 glutathione synthetase; Provisional; Region: PRK05246 713604019862 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 713604019863 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 713604019864 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604019865 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 713604019866 active site 713604019867 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604019868 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604019869 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604019870 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 713604019871 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 713604019872 putative C-terminal domain interface [polypeptide binding]; other site 713604019873 putative GSH binding site (G-site) [chemical binding]; other site 713604019874 putative dimer interface [polypeptide binding]; other site 713604019875 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 713604019876 N-terminal domain interface [polypeptide binding]; other site 713604019877 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604019878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604019879 DNA-binding site [nucleotide binding]; DNA binding site 713604019880 UTRA domain; Region: UTRA; cl17743 713604019881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604019882 D-galactonate transporter; Region: 2A0114; TIGR00893 713604019883 putative substrate translocation pore; other site 713604019884 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 713604019885 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 713604019886 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 713604019887 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604019888 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604019889 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 713604019890 Domain of unknown function (DUF4417); Region: DUF4417; pfam14386 713604019891 ParB-like nuclease domain; Region: ParB; smart00470 713604019892 Replication-relaxation; Region: Replic_Relax; pfam13814 713604019893 Lsr2; Region: Lsr2; pfam11774 713604019894 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604019895 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 713604019896 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 713604019897 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 713604019898 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 713604019899 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 713604019900 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604019901 RHS Repeat; Region: RHS_repeat; pfam05593 713604019902 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604019903 RHS Repeat; Region: RHS_repeat; cl11982 713604019904 RHS Repeat; Region: RHS_repeat; cl11982 713604019905 RHS Repeat; Region: RHS_repeat; pfam05593 713604019906 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604019907 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604019908 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604019909 catalytic residue [active] 713604019910 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 713604019911 NlpC/P60 family; Region: NLPC_P60; pfam00877 713604019912 AAA-like domain; Region: AAA_10; pfam12846 713604019913 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 713604019914 Uncharacterized conserved protein [Function unknown]; Region: COG4278 713604019915 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604019916 substrate binding site [chemical binding]; other site 713604019917 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604019918 active site 713604019919 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 713604019920 substrate binding pocket [chemical binding]; other site 713604019921 dimer interface [polypeptide binding]; other site 713604019922 inhibitor binding site; inhibition site 713604019923 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 713604019924 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604019925 non-specific DNA binding site [nucleotide binding]; other site 713604019926 salt bridge; other site 713604019927 sequence-specific DNA binding site [nucleotide binding]; other site 713604019928 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 713604019929 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 713604019930 putative transposase OrfB; Reviewed; Region: PHA02517 713604019931 HTH-like domain; Region: HTH_21; pfam13276 713604019932 Integrase core domain; Region: rve; pfam00665 713604019933 Integrase core domain; Region: rve_3; pfam13683 713604019934 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604019935 Transposase; Region: HTH_Tnp_1; cl17663 713604019936 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604019937 hydrophobic ligand binding site; other site 713604019938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019939 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604019940 NAD(P) binding site [chemical binding]; other site 713604019941 active site 713604019942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604019943 putative DNA binding site [nucleotide binding]; other site 713604019944 putative Zn2+ binding site [ion binding]; other site 713604019945 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604019946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019947 NAD(P) binding site [chemical binding]; other site 713604019948 active site 713604019949 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604019950 FO synthase; Reviewed; Region: fbiC; PRK09234 713604019951 FO synthase; Reviewed; Region: fbiC; PRK09234 713604019952 FO synthase; Reviewed; Region: fbiC; PRK09234 713604019953 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604019954 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604019955 short chain dehydrogenase; Provisional; Region: PRK06172 713604019956 classical (c) SDRs; Region: SDR_c; cd05233 713604019957 NAD(P) binding site [chemical binding]; other site 713604019958 active site 713604019959 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 713604019960 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 713604019961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604019962 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 713604019963 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604019964 Cytochrome P450; Region: p450; cl12078 713604019965 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604019966 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604019967 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604019968 DNA binding residues [nucleotide binding] 713604019969 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604019970 FAD binding domain; Region: FAD_binding_4; pfam01565 713604019971 Berberine and berberine like; Region: BBE; pfam08031 713604019972 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604019973 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604019974 RibD C-terminal domain; Region: RibD_C; cl17279 713604019975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604019976 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604019977 putative substrate translocation pore; other site 713604019978 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 713604019979 Leucine rich repeat; Region: LRR_8; pfam13855 713604019980 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 713604019981 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 713604019982 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 713604019983 protein-splicing catalytic site; other site 713604019984 thioester formation/cholesterol transfer; other site 713604019985 Pretoxin HINT domain; Region: PT-HINT; pfam07591 713604019986 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604019987 intermolecular salt bridges; other site 713604019988 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 713604019989 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604019990 Methyltransferase domain; Region: Methyltransf_12; pfam08242 713604019991 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604019992 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604019993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604019994 Cupin; Region: Cupin_6; pfam12852 713604019995 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604019996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604019997 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604019998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604019999 NAD(P) binding site [chemical binding]; other site 713604020000 active site 713604020001 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604020002 active site 713604020003 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 713604020004 PBP superfamily domain; Region: PBP_like_2; cl17296 713604020005 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 713604020006 active site 713604020007 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 713604020008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020009 dimer interface [polypeptide binding]; other site 713604020010 conserved gate region; other site 713604020011 putative PBP binding loops; other site 713604020012 ABC-ATPase subunit interface; other site 713604020013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020014 dimer interface [polypeptide binding]; other site 713604020015 conserved gate region; other site 713604020016 putative PBP binding loops; other site 713604020017 ABC-ATPase subunit interface; other site 713604020018 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 713604020019 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 713604020020 Walker A/P-loop; other site 713604020021 ATP binding site [chemical binding]; other site 713604020022 Q-loop/lid; other site 713604020023 ABC transporter signature motif; other site 713604020024 Walker B; other site 713604020025 D-loop; other site 713604020026 H-loop/switch region; other site 713604020027 PBP superfamily domain; Region: PBP_like_2; cl17296 713604020028 PBP superfamily domain; Region: PBP_like_2; pfam12849 713604020029 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604020030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020031 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604020032 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604020033 active site 713604020034 O-Antigen ligase; Region: Wzy_C; cl04850 713604020035 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 713604020036 active site 713604020037 catalytic triad [active] 713604020038 oxyanion hole [active] 713604020039 amidase; Provisional; Region: PRK06170 713604020040 Amidase; Region: Amidase; cl11426 713604020041 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604020042 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604020043 NAD(P) binding site [chemical binding]; other site 713604020044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604020045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604020046 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 713604020047 dimerization interface [polypeptide binding]; other site 713604020048 substrate binding pocket [chemical binding]; other site 713604020049 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604020050 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604020051 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604020052 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604020053 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604020054 putative sugar binding sites [chemical binding]; other site 713604020055 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604020056 putative sugar binding sites [chemical binding]; other site 713604020057 Q-X-W motif; other site 713604020058 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 713604020059 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604020060 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604020061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020062 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 713604020063 NAD(P) binding site [chemical binding]; other site 713604020064 active site 713604020065 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 713604020066 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604020067 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604020068 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 713604020069 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604020070 Walker A/P-loop; other site 713604020071 ATP binding site [chemical binding]; other site 713604020072 Q-loop/lid; other site 713604020073 ABC transporter signature motif; other site 713604020074 Walker B; other site 713604020075 D-loop; other site 713604020076 H-loop/switch region; other site 713604020077 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 713604020078 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 713604020079 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 713604020080 Cellulose binding domain; Region: CBM_2; pfam00553 713604020081 alpha-galactosidase; Region: PLN02808; cl17638 713604020082 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604020083 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604020084 putative sugar binding sites [chemical binding]; other site 713604020085 Q-X-W motif; other site 713604020086 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 713604020087 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 713604020088 putative active site [active] 713604020089 putative catalytic site [active] 713604020090 putative Zn binding site [ion binding]; other site 713604020091 O-Antigen ligase; Region: Wzy_C; pfam04932 713604020092 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 713604020093 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 713604020094 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604020095 putative ADP-binding pocket [chemical binding]; other site 713604020096 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 713604020097 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604020098 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604020099 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 713604020100 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604020101 TM1410 hypothetical-related protein; Region: DUF297; cl00997 713604020102 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 713604020103 Bacterial sugar transferase; Region: Bac_transf; pfam02397 713604020104 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604020105 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 713604020106 active site 713604020107 hypothetical protein; Provisional; Region: PRK07233 713604020108 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604020109 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 713604020110 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 713604020111 active site 713604020112 homodimer interface [polypeptide binding]; other site 713604020113 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 713604020114 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 713604020115 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604020116 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604020117 active site 713604020118 metal binding site [ion binding]; metal-binding site 713604020119 Right handed beta helix region; Region: Beta_helix; pfam13229 713604020120 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604020121 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604020122 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604020123 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 713604020124 metal binding site [ion binding]; metal-binding site 713604020125 active site 713604020126 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 713604020127 active site 713604020128 catalytic triad [active] 713604020129 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 713604020130 active site 713604020131 catalytic triad [active] 713604020132 oxyanion hole [active] 713604020133 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604020134 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604020135 Interdomain contacts; other site 713604020136 Cellulose binding domain; Region: CBM_2; pfam00553 713604020137 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 713604020138 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604020139 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604020140 DNA binding site [nucleotide binding] 713604020141 domain linker motif; other site 713604020142 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604020143 dimerization interface [polypeptide binding]; other site 713604020144 ligand binding site [chemical binding]; other site 713604020145 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604020146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020147 dimer interface [polypeptide binding]; other site 713604020148 conserved gate region; other site 713604020149 putative PBP binding loops; other site 713604020150 ABC-ATPase subunit interface; other site 713604020151 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 713604020152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020153 putative PBP binding loops; other site 713604020154 ABC-ATPase subunit interface; other site 713604020155 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604020156 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604020157 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 713604020158 active site 713604020159 catalytic triad [active] 713604020160 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604020161 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604020162 anti sigma factor interaction site; other site 713604020163 regulatory phosphorylation site [posttranslational modification]; other site 713604020164 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 713604020165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020167 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604020168 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604020169 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604020170 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 713604020171 catalytic site [active] 713604020172 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604020173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604020174 PAS domain; Region: PAS_9; pfam13426 713604020175 putative active site [active] 713604020176 heme pocket [chemical binding]; other site 713604020177 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604020178 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604020179 anti sigma factor interaction site; other site 713604020180 regulatory phosphorylation site [posttranslational modification]; other site 713604020181 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 713604020182 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 713604020183 dimer interface [polypeptide binding]; other site 713604020184 active site 713604020185 catalytic residue [active] 713604020186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604020187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604020188 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604020189 putative dimerization interface [polypeptide binding]; other site 713604020190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604020191 S-adenosylmethionine binding site [chemical binding]; other site 713604020192 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 713604020193 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 713604020194 glutaminase active site [active] 713604020195 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 713604020196 dimer interface [polypeptide binding]; other site 713604020197 active site 713604020198 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 713604020199 dimer interface [polypeptide binding]; other site 713604020200 active site 713604020201 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604020202 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604020203 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 713604020204 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 713604020205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020206 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604020207 Cytochrome P450; Region: p450; cl12078 713604020208 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604020209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604020212 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604020213 active site 713604020214 catalytic tetrad [active] 713604020215 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 713604020216 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604020217 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604020218 MarR family; Region: MarR_2; cl17246 713604020219 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604020220 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 713604020221 Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662 713604020222 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604020223 Interdomain contacts; other site 713604020224 Cytokine receptor motif; other site 713604020225 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 713604020226 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 713604020227 active site 713604020228 PHP Thumb interface [polypeptide binding]; other site 713604020229 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 713604020230 generic binding surface I; other site 713604020231 generic binding surface II; other site 713604020232 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604020233 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604020234 DNA binding residues [nucleotide binding] 713604020235 YCII-related domain; Region: YCII; cl00999 713604020236 RibD C-terminal domain; Region: RibD_C; cl17279 713604020237 arginine decarboxylase; Provisional; Region: PRK15029 713604020238 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 713604020239 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604020240 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604020241 catalytic residue [active] 713604020242 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 713604020243 Y-family of DNA polymerases; Region: PolY; cl12025 713604020244 DNA binding site [nucleotide binding] 713604020245 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 713604020246 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 713604020247 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604020248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604020249 DNA-binding site [nucleotide binding]; DNA binding site 713604020250 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604020251 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604020252 Walker A/P-loop; other site 713604020253 ATP binding site [chemical binding]; other site 713604020254 Q-loop/lid; other site 713604020255 ABC transporter signature motif; other site 713604020256 Walker B; other site 713604020257 D-loop; other site 713604020258 H-loop/switch region; other site 713604020259 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 713604020260 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 713604020261 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 713604020262 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604020263 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 713604020264 active site 713604020265 catalytic triad [active] 713604020266 oxyanion hole [active] 713604020267 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604020268 classical (c) SDRs; Region: SDR_c; cd05233 713604020269 NAD(P) binding site [chemical binding]; other site 713604020270 active site 713604020271 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 713604020272 Ferritin-like domain; Region: Ferritin; pfam00210 713604020273 ferroxidase diiron center [ion binding]; other site 713604020274 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604020275 CoenzymeA binding site [chemical binding]; other site 713604020276 subunit interaction site [polypeptide binding]; other site 713604020277 PHB binding site; other site 713604020278 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 713604020279 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 713604020280 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604020281 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604020282 G1 box; other site 713604020283 GTP/Mg2+ binding site [chemical binding]; other site 713604020284 G2 box; other site 713604020285 Switch I region; other site 713604020286 G3 box; other site 713604020287 Switch II region; other site 713604020288 G4 box; other site 713604020289 G5 box; other site 713604020290 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604020291 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 713604020292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604020293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604020294 ATP binding site [chemical binding]; other site 713604020295 Mg2+ binding site [ion binding]; other site 713604020296 G-X-G motif; other site 713604020297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604020298 dimerization interface [polypeptide binding]; other site 713604020299 putative DNA binding site [nucleotide binding]; other site 713604020300 putative Zn2+ binding site [ion binding]; other site 713604020301 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604020302 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 713604020303 putative NAD(P) binding site [chemical binding]; other site 713604020304 active site 713604020305 putative substrate binding site [chemical binding]; other site 713604020306 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 713604020307 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604020308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604020309 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604020310 DNA binding residues [nucleotide binding] 713604020311 dimerization interface [polypeptide binding]; other site 713604020312 Tannase and feruloyl esterase; Region: Tannase; pfam07519 713604020313 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604020314 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604020315 active site 713604020316 catalytic tetrad [active] 713604020317 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604020318 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604020319 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 713604020320 active site 713604020321 GAF domain; Region: GAF_2; pfam13185 713604020322 ANTAR domain; Region: ANTAR; pfam03861 713604020323 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 713604020324 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604020325 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604020326 putative sugar binding sites [chemical binding]; other site 713604020327 Q-X-W motif; other site 713604020328 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 713604020329 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 713604020330 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 713604020331 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 713604020332 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604020333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604020334 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604020335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020336 putative PBP binding loops; other site 713604020337 ABC-ATPase subunit interface; other site 713604020338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604020339 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 713604020340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604020341 dimer interface [polypeptide binding]; other site 713604020342 ABC-ATPase subunit interface; other site 713604020343 putative PBP binding loops; other site 713604020344 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604020345 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604020346 DNA binding site [nucleotide binding] 713604020347 domain linker motif; other site 713604020348 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 713604020349 ligand binding site [chemical binding]; other site 713604020350 dimerization interface (open form) [polypeptide binding]; other site 713604020351 dimerization interface (closed form) [polypeptide binding]; other site 713604020352 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 713604020353 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 713604020354 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604020355 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604020356 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 713604020357 putative NAD(P) binding site [chemical binding]; other site 713604020358 tetracycline repressor protein TetR; Provisional; Region: PRK13756 713604020359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020360 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604020361 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 713604020362 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 713604020363 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 713604020364 Fasciclin domain; Region: Fasciclin; pfam02469 713604020365 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 713604020366 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 713604020367 Moco binding site; other site 713604020368 metal coordination site [ion binding]; other site 713604020369 putative anti-sigmaE protein; Provisional; Region: PRK13920 713604020370 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 713604020371 Anti-sigma-K factor rskA; Region: RskA; pfam10099 713604020372 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 713604020373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604020374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604020375 DNA binding residues [nucleotide binding] 713604020376 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 713604020377 acyl-CoA synthetase; Validated; Region: PRK06188 713604020378 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604020379 active site 713604020380 CoA binding site [chemical binding]; other site 713604020381 AMP binding site [chemical binding]; other site 713604020382 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 713604020383 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 713604020384 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 713604020385 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604020386 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604020387 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 713604020388 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 713604020389 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604020390 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 713604020391 RNA binding surface [nucleotide binding]; other site 713604020392 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604020393 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604020394 DNA binding residues [nucleotide binding] 713604020395 Cupin domain; Region: Cupin_2; pfam07883 713604020396 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 713604020397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604020398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604020399 DNA binding residues [nucleotide binding] 713604020400 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604020401 active site 713604020402 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604020403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604020404 metal binding site [ion binding]; metal-binding site 713604020405 active site 713604020406 I-site; other site 713604020407 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604020408 Putative cyclase; Region: Cyclase; cl00814 713604020409 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604020410 Glyco_18 domain; Region: Glyco_18; smart00636 713604020411 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 713604020412 active site 713604020413 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 713604020414 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604020415 catalytic residue [active] 713604020416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604020417 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604020418 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604020419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604020420 S-adenosylmethionine binding site [chemical binding]; other site 713604020421 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604020422 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 713604020423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604020424 non-specific DNA binding site [nucleotide binding]; other site 713604020425 salt bridge; other site 713604020426 sequence-specific DNA binding site [nucleotide binding]; other site 713604020427 amidase; Provisional; Region: PRK07869 713604020428 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 713604020429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604020430 S-adenosylmethionine binding site [chemical binding]; other site 713604020431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604020432 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604020433 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 713604020434 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604020435 Methyltransferase domain; Region: Methyltransf_24; pfam13578 713604020436 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 713604020437 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 713604020438 metal ion-dependent adhesion site (MIDAS); other site 713604020439 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 713604020440 active site 713604020441 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604020442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604020443 DNA-binding site [nucleotide binding]; DNA binding site 713604020444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604020445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604020446 homodimer interface [polypeptide binding]; other site 713604020447 catalytic residue [active] 713604020448 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604020449 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604020450 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604020451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604020452 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 713604020453 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 713604020454 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604020455 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604020456 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604020457 protein binding site [polypeptide binding]; other site 713604020458 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 713604020459 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604020460 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 713604020461 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 713604020462 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 713604020463 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 713604020464 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 713604020465 putative active site [active] 713604020466 putative substrate binding site [chemical binding]; other site 713604020467 putative cosubstrate binding site; other site 713604020468 catalytic site [active] 713604020469 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 713604020470 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 713604020471 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 713604020472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604020473 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 713604020474 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 713604020475 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 713604020476 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 713604020477 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604020478 hydroxyglutarate oxidase; Provisional; Region: PRK11728 713604020479 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 713604020480 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 713604020481 dimer interface [polypeptide binding]; other site 713604020482 active site 713604020483 glycine-pyridoxal phosphate binding site [chemical binding]; other site 713604020484 folate binding site [chemical binding]; other site 713604020485 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604020486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604020487 DNA-binding site [nucleotide binding]; DNA binding site 713604020488 FCD domain; Region: FCD; pfam07729 713604020489 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 713604020490 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 713604020491 [2Fe-2S] cluster binding site [ion binding]; other site 713604020492 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 713604020493 putative alpha subunit interface [polypeptide binding]; other site 713604020494 putative active site [active] 713604020495 putative substrate binding site [chemical binding]; other site 713604020496 Fe binding site [ion binding]; other site 713604020497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 713604020498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020499 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604020500 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 713604020501 tetramerization interface [polypeptide binding]; other site 713604020502 NAD(P) binding site [chemical binding]; other site 713604020503 catalytic residues [active] 713604020504 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 713604020505 choline dehydrogenase; Validated; Region: PRK02106 713604020506 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604020507 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 713604020508 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604020509 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 713604020510 [2Fe-2S] cluster binding site [ion binding]; other site 713604020511 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 713604020512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604020513 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604020514 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020516 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 713604020517 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 713604020518 E3 interaction surface; other site 713604020519 lipoyl attachment site [posttranslational modification]; other site 713604020520 e3 binding domain; Region: E3_binding; pfam02817 713604020521 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 713604020522 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 713604020523 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 713604020524 TPP binding site [chemical binding]; other site 713604020525 alpha subunit interface [polypeptide binding]; other site 713604020526 heterodimer interface [polypeptide binding]; other site 713604020527 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604020528 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 713604020529 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 713604020530 tetramer interface [polypeptide binding]; other site 713604020531 TPP-binding site [chemical binding]; other site 713604020532 heterodimer interface [polypeptide binding]; other site 713604020533 phosphorylation loop region [posttranslational modification] 713604020534 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 713604020535 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 713604020536 AsnC family; Region: AsnC_trans_reg; pfam01037 713604020537 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 713604020538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604020539 Coenzyme A binding pocket [chemical binding]; other site 713604020540 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604020541 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604020542 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604020543 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604020544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604020545 active site 713604020546 phosphorylation site [posttranslational modification] 713604020547 intermolecular recognition site; other site 713604020548 dimerization interface [polypeptide binding]; other site 713604020549 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604020550 DNA binding site [nucleotide binding] 713604020551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604020552 dimerization interface [polypeptide binding]; other site 713604020553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604020554 dimer interface [polypeptide binding]; other site 713604020555 phosphorylation site [posttranslational modification] 713604020556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604020557 ATP binding site [chemical binding]; other site 713604020558 Mg2+ binding site [ion binding]; other site 713604020559 G-X-G motif; other site 713604020560 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 713604020561 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604020562 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 713604020563 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604020564 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 713604020565 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 713604020566 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 713604020567 putative active site [active] 713604020568 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604020569 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604020570 active site 713604020571 ATP binding site [chemical binding]; other site 713604020572 substrate binding site [chemical binding]; other site 713604020573 activation loop (A-loop); other site 713604020574 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604020575 dimerization interface [polypeptide binding]; other site 713604020576 putative DNA binding site [nucleotide binding]; other site 713604020577 putative Zn2+ binding site [ion binding]; other site 713604020578 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 713604020579 putative hydrophobic ligand binding site [chemical binding]; other site 713604020580 Imelysin; Region: Peptidase_M75; pfam09375 713604020581 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 713604020582 Phosphoesterase family; Region: Phosphoesterase; pfam04185 713604020583 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604020584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 713604020585 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 713604020586 anti sigma factor interaction site; other site 713604020587 regulatory phosphorylation site [posttranslational modification]; other site 713604020588 Response regulator receiver domain; Region: Response_reg; pfam00072 713604020589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604020590 active site 713604020591 phosphorylation site [posttranslational modification] 713604020592 intermolecular recognition site; other site 713604020593 dimerization interface [polypeptide binding]; other site 713604020594 CHASE3 domain; Region: CHASE3; pfam05227 713604020595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604020596 dimerization interface [polypeptide binding]; other site 713604020597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604020598 dimer interface [polypeptide binding]; other site 713604020599 phosphorylation site [posttranslational modification] 713604020600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604020601 ATP binding site [chemical binding]; other site 713604020602 Mg2+ binding site [ion binding]; other site 713604020603 G-X-G motif; other site 713604020604 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 713604020605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604020606 active site 713604020607 phosphorylation site [posttranslational modification] 713604020608 intermolecular recognition site; other site 713604020609 dimerization interface [polypeptide binding]; other site 713604020610 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 713604020611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 713604020612 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 713604020613 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604020614 Secretory lipase; Region: LIP; pfam03583 713604020615 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604020616 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604020617 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604020618 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604020619 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604020620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020621 KR domain; Region: KR; pfam08659 713604020622 NAD(P) binding site [chemical binding]; other site 713604020623 active site 713604020624 mce related protein; Region: MCE; pfam02470 713604020625 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604020626 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604020627 mce related protein; Region: MCE; pfam02470 713604020628 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604020629 mce related protein; Region: MCE; pfam02470 713604020630 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604020631 mce related protein; Region: MCE; pfam02470 713604020632 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604020633 mce related protein; Region: MCE; pfam02470 713604020634 mce related protein; Region: MCE; pfam02470 713604020635 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 713604020636 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 713604020637 Permease; Region: Permease; pfam02405 713604020638 Permease; Region: Permease; pfam02405 713604020639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604020640 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604020641 Walker A/P-loop; other site 713604020642 ATP binding site [chemical binding]; other site 713604020643 Q-loop/lid; other site 713604020644 ABC transporter signature motif; other site 713604020645 Walker B; other site 713604020646 D-loop; other site 713604020647 H-loop/switch region; other site 713604020648 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604020649 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604020650 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 713604020651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604020652 binding surface 713604020653 TPR motif; other site 713604020654 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604020655 CHAT domain; Region: CHAT; pfam12770 713604020656 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604020657 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604020658 active site 713604020659 metal binding site [ion binding]; metal-binding site 713604020660 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 713604020661 Growth-arrest specific micro-tubule binding; Region: GAS; pfam13851 713604020662 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604020663 nudix motif; other site 713604020664 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604020665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020666 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604020667 hypothetical protein; Provisional; Region: PRK14059 713604020668 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 713604020669 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 713604020670 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604020671 active site 713604020672 ATP binding site [chemical binding]; other site 713604020673 substrate binding site [chemical binding]; other site 713604020674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020676 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604020677 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 713604020678 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 713604020679 Hemerythrin-like domain; Region: Hr-like; cd12108 713604020680 Fe binding site [ion binding]; other site 713604020681 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604020682 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604020683 acyl-activating enzyme (AAE) consensus motif; other site 713604020684 AMP binding site [chemical binding]; other site 713604020685 active site 713604020686 CoA binding site [chemical binding]; other site 713604020687 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 713604020688 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 713604020689 molybdopterin cofactor binding site; other site 713604020690 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 713604020691 molybdopterin cofactor binding site; other site 713604020692 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 713604020693 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604020694 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604020695 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604020696 hydrophobic ligand binding site; other site 713604020697 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604020698 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604020699 Cupin domain; Region: Cupin_2; cl17218 713604020700 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604020701 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604020702 conserved cys residue [active] 713604020703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020707 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604020708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604020709 Coenzyme A binding pocket [chemical binding]; other site 713604020710 Protein of unknown function DUF111; Region: DUF111; cl03398 713604020711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604020712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604020713 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604020714 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 713604020715 Domain of unknown function (DUF222); Region: DUF222; pfam02720 713604020716 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 713604020717 active site 713604020718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604020719 Coenzyme A binding pocket [chemical binding]; other site 713604020720 short chain dehydrogenase; Provisional; Region: PRK07041 713604020721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020722 NAD(P) binding site [chemical binding]; other site 713604020723 active site 713604020724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604020725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604020726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 713604020727 dimerization interface [polypeptide binding]; other site 713604020728 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604020729 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604020730 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604020731 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 713604020732 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 713604020733 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 713604020734 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604020735 putative active site [active] 713604020736 putative metal binding site [ion binding]; other site 713604020737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604020738 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604020739 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 713604020740 putative ADP-ribose binding site [chemical binding]; other site 713604020741 putative active site [active] 713604020742 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 713604020743 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 713604020744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604020745 motif II; other site 713604020746 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 713604020747 nudix motif; other site 713604020748 Predicted membrane protein [Function unknown]; Region: COG2259 713604020749 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604020750 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604020751 G1 box; other site 713604020752 GTP/Mg2+ binding site [chemical binding]; other site 713604020753 G2 box; other site 713604020754 Switch I region; other site 713604020755 G3 box; other site 713604020756 Switch II region; other site 713604020757 G4 box; other site 713604020758 G5 box; other site 713604020759 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604020760 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604020761 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604020762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604020763 ATP binding site [chemical binding]; other site 713604020764 Mg2+ binding site [ion binding]; other site 713604020765 G-X-G motif; other site 713604020766 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 713604020767 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604020768 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 713604020769 acyl-activating enzyme (AAE) consensus motif; other site 713604020770 acyl-activating enzyme (AAE) consensus motif; other site 713604020771 putative AMP binding site [chemical binding]; other site 713604020772 putative active site [active] 713604020773 putative CoA binding site [chemical binding]; other site 713604020774 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604020775 classical (c) SDRs; Region: SDR_c; cd05233 713604020776 NAD(P) binding site [chemical binding]; other site 713604020777 active site 713604020778 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604020779 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604020780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604020781 metal binding site [ion binding]; metal-binding site 713604020782 active site 713604020783 I-site; other site 713604020784 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 713604020785 Transcriptional regulator [Transcription]; Region: LytR; COG1316 713604020786 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 713604020787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604020788 non-specific DNA binding site [nucleotide binding]; other site 713604020789 salt bridge; other site 713604020790 sequence-specific DNA binding site [nucleotide binding]; other site 713604020791 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604020792 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604020793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020795 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 713604020796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020797 NAD(P) binding site [chemical binding]; other site 713604020798 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 713604020799 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604020800 conserved cys residue [active] 713604020801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020803 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604020804 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604020805 active site 713604020806 catalytic tetrad [active] 713604020807 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 713604020808 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 713604020809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604020810 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 713604020811 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 713604020812 catalytic triad [active] 713604020813 NACHT domain; Region: NACHT; pfam05729 713604020814 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 713604020815 active site 713604020816 dimerization interface [polypeptide binding]; other site 713604020817 ribonuclease PH; Reviewed; Region: rph; PRK00173 713604020818 Ribonuclease PH; Region: RNase_PH_bact; cd11362 713604020819 hexamer interface [polypeptide binding]; other site 713604020820 active site 713604020821 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 713604020822 glutamate racemase; Provisional; Region: PRK00865 713604020823 Rhomboid family; Region: Rhomboid; pfam01694 713604020824 N-acetyltransferase; Region: Acetyltransf_2; cl00949 713604020825 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 713604020826 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 713604020827 aspartate racemase; Region: asp_race; TIGR00035 713604020828 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604020829 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604020830 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 713604020831 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604020832 dimer interface [polypeptide binding]; other site 713604020833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604020834 catalytic residue [active] 713604020835 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 713604020836 MoaE interaction surface [polypeptide binding]; other site 713604020837 MoeB interaction surface [polypeptide binding]; other site 713604020838 thiocarboxylated glycine; other site 713604020839 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 713604020840 MPN+ (JAMM) motif; other site 713604020841 Zinc-binding site [ion binding]; other site 713604020842 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 713604020843 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 713604020844 cleavage site 713604020845 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 713604020846 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 713604020847 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 713604020848 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 713604020849 active site 713604020850 Isochorismatase family; Region: Isochorismatase; pfam00857 713604020851 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 713604020852 catalytic triad [active] 713604020853 conserved cis-peptide bond; other site 713604020854 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 713604020855 active site 713604020856 intersubunit interface [polypeptide binding]; other site 713604020857 catalytic residue [active] 713604020858 BioY family; Region: BioY; pfam02632 713604020859 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 713604020860 DEAD/DEAH box helicase; Region: DEAD; pfam00270 713604020861 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604020862 putative Mg++ binding site [ion binding]; other site 713604020863 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 713604020864 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 713604020865 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 713604020866 dimer interface [polypeptide binding]; other site 713604020867 putative active site [active] 713604020868 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 713604020869 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 713604020870 phosphoserine phosphatase SerB; Region: serB; TIGR00338 713604020871 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 713604020872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604020873 motif II; other site 713604020874 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 713604020875 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 713604020876 D-pathway; other site 713604020877 Putative ubiquinol binding site [chemical binding]; other site 713604020878 Low-spin heme (heme b) binding site [chemical binding]; other site 713604020879 Putative water exit pathway; other site 713604020880 Binuclear center (heme o3/CuB) [ion binding]; other site 713604020881 K-pathway; other site 713604020882 Putative proton exit pathway; other site 713604020883 Phosphotransferase enzyme family; Region: APH; pfam01636 713604020884 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 713604020885 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604020886 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604020887 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604020888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604020889 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 713604020890 active site 713604020891 Transposase; Region: HTH_Tnp_1; pfam01527 713604020892 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604020893 HTH-like domain; Region: HTH_21; pfam13276 713604020894 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 713604020895 Integrase core domain; Region: rve; pfam00665 713604020896 Integrase core domain; Region: rve_3; pfam13683 713604020897 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 713604020898 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 713604020899 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 713604020900 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 713604020901 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604020902 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604020903 catalytic residue [active] 713604020904 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604020905 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604020906 putative DNA binding site [nucleotide binding]; other site 713604020907 putative Zn2+ binding site [ion binding]; other site 713604020908 AsnC family; Region: AsnC_trans_reg; pfam01037 713604020909 AAA domain; Region: AAA_17; pfam13207 713604020910 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604020911 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604020912 putative DNA binding site [nucleotide binding]; other site 713604020913 putative Zn2+ binding site [ion binding]; other site 713604020914 AsnC family; Region: AsnC_trans_reg; pfam01037 713604020915 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604020916 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 713604020917 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 713604020918 nucleoside/Zn binding site; other site 713604020919 dimer interface [polypeptide binding]; other site 713604020920 catalytic motif [active] 713604020921 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 713604020922 homodimer interaction site [polypeptide binding]; other site 713604020923 cofactor binding site; other site 713604020924 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 713604020925 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604020926 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604020927 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 713604020928 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604020929 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604020930 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 713604020931 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 713604020932 dimerization domain swap beta strand [polypeptide binding]; other site 713604020933 regulatory protein interface [polypeptide binding]; other site 713604020934 active site 713604020935 regulatory phosphorylation site [posttranslational modification]; other site 713604020936 DAK2 domain; Region: Dak2; cl03685 713604020937 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 713604020938 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 713604020939 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 713604020940 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 713604020941 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 713604020942 Na binding site [ion binding]; other site 713604020943 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 713604020944 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 713604020945 hypothetical protein; Provisional; Region: PRK03298 713604020946 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 713604020947 dimer interface [polypeptide binding]; other site 713604020948 ADP-ribose binding site [chemical binding]; other site 713604020949 active site 713604020950 nudix motif; other site 713604020951 metal binding site [ion binding]; metal-binding site 713604020952 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 713604020953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020955 enoyl-CoA hydratase; Validated; Region: PRK08139 713604020956 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604020957 substrate binding site [chemical binding]; other site 713604020958 oxyanion hole (OAH) forming residues; other site 713604020959 trimer interface [polypeptide binding]; other site 713604020960 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 713604020961 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 713604020962 conserved cys residue [active] 713604020963 Isochorismatase family; Region: Isochorismatase; pfam00857 713604020964 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 713604020965 catalytic triad [active] 713604020966 conserved cis-peptide bond; other site 713604020967 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 713604020968 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 713604020969 B12 binding site [chemical binding]; other site 713604020970 cobalt ligand [ion binding]; other site 713604020971 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 713604020972 Bacterial PH domain; Region: DUF304; cl01348 713604020973 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604020974 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604020975 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 713604020976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604020977 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604020978 NAD(P) binding site [chemical binding]; other site 713604020979 active site 713604020980 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604020981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604020982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604020983 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 713604020984 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 713604020985 hinge; other site 713604020986 active site 713604020987 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 713604020988 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 713604020989 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 713604020990 hinge; other site 713604020991 active site 713604020992 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 713604020993 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 713604020994 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 713604020995 gamma subunit interface [polypeptide binding]; other site 713604020996 epsilon subunit interface [polypeptide binding]; other site 713604020997 LBP interface [polypeptide binding]; other site 713604020998 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 713604020999 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 713604021000 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 713604021001 alpha subunit interaction interface [polypeptide binding]; other site 713604021002 Walker A motif; other site 713604021003 ATP binding site [chemical binding]; other site 713604021004 Walker B motif; other site 713604021005 inhibitor binding site; inhibition site 713604021006 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 713604021007 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 713604021008 core domain interface [polypeptide binding]; other site 713604021009 delta subunit interface [polypeptide binding]; other site 713604021010 epsilon subunit interface [polypeptide binding]; other site 713604021011 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 713604021012 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 713604021013 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 713604021014 beta subunit interaction interface [polypeptide binding]; other site 713604021015 Walker A motif; other site 713604021016 ATP binding site [chemical binding]; other site 713604021017 Walker B motif; other site 713604021018 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 713604021019 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 713604021020 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 713604021021 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 713604021022 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 713604021023 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 713604021024 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 713604021025 Mg++ binding site [ion binding]; other site 713604021026 putative catalytic motif [active] 713604021027 substrate binding site [chemical binding]; other site 713604021028 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 713604021029 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 713604021030 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 713604021031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604021032 S-adenosylmethionine binding site [chemical binding]; other site 713604021033 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 713604021034 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 713604021035 Ligand binding site; other site 713604021036 Putative Catalytic site; other site 713604021037 DXD motif; other site 713604021038 Predicted membrane protein [Function unknown]; Region: COG2246 713604021039 GtrA-like protein; Region: GtrA; pfam04138 713604021040 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 713604021041 peptide chain release factor 1; Validated; Region: prfA; PRK00591 713604021042 This domain is found in peptide chain release factors; Region: PCRF; smart00937 713604021043 RF-1 domain; Region: RF-1; pfam00472 713604021044 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 713604021045 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 713604021046 transcription termination factor Rho; Provisional; Region: PRK12608 713604021047 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 713604021048 RNA binding site [nucleotide binding]; other site 713604021049 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 713604021050 multimer interface [polypeptide binding]; other site 713604021051 Walker A motif; other site 713604021052 ATP binding site [chemical binding]; other site 713604021053 Walker B motif; other site 713604021054 homoserine kinase; Provisional; Region: PRK01212 713604021055 threonine synthase; Reviewed; Region: PRK06721 713604021056 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 713604021057 homodimer interface [polypeptide binding]; other site 713604021058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021059 catalytic residue [active] 713604021060 homoserine dehydrogenase; Provisional; Region: PRK06349 713604021061 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 713604021062 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 713604021063 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 713604021064 diaminopimelate decarboxylase; Region: lysA; TIGR01048 713604021065 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 713604021066 active site 713604021067 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604021068 substrate binding site [chemical binding]; other site 713604021069 catalytic residues [active] 713604021070 dimer interface [polypeptide binding]; other site 713604021071 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 713604021072 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 713604021073 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 713604021074 active site 713604021075 HIGH motif; other site 713604021076 KMSK motif region; other site 713604021077 tRNA binding surface [nucleotide binding]; other site 713604021078 DALR anticodon binding domain; Region: DALR_1; smart00836 713604021079 anticodon binding site; other site 713604021080 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 713604021081 Domain of unknown function (DUF305); Region: DUF305; pfam03713 713604021082 RIP homotypic interaction motif; Region: RHIM; pfam12721 713604021083 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 713604021084 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604021085 MarR family; Region: MarR; pfam01047 713604021086 short chain dehydrogenase; Provisional; Region: PRK05993 713604021087 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 713604021088 NADP binding site [chemical binding]; other site 713604021089 active site 713604021090 steroid binding site; other site 713604021091 Epoxide hydrolase N terminus; Region: EHN; pfam06441 713604021092 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604021093 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 713604021094 active site 713604021095 catalytic residues [active] 713604021096 DNA binding site [nucleotide binding] 713604021097 Int/Topo IB signature motif; other site 713604021098 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604021099 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 713604021100 putative NAD(P) binding site [chemical binding]; other site 713604021101 TIGR03086 family protein; Region: TIGR03086 713604021102 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604021103 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604021104 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604021105 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 713604021106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604021107 Transposase; Region: HTH_Tnp_1; cl17663 713604021108 putative transposase OrfB; Reviewed; Region: PHA02517 713604021109 HTH-like domain; Region: HTH_21; pfam13276 713604021110 Integrase core domain; Region: rve; pfam00665 713604021111 Integrase core domain; Region: rve_3; pfam13683 713604021112 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 713604021113 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604021114 substrate binding site [chemical binding]; other site 713604021115 ATP binding site [chemical binding]; other site 713604021116 Survival protein SurE; Region: SurE; cl00448 713604021117 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604021118 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604021119 AAA ATPase domain; Region: AAA_16; pfam13191 713604021120 NB-ARC domain; Region: NB-ARC; pfam00931 713604021121 TPR repeat; Region: TPR_11; pfam13414 713604021122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604021123 TPR motif; other site 713604021124 binding surface 713604021125 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604021126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604021127 TPR motif; other site 713604021128 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604021129 binding surface 713604021130 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604021131 Cytochrome P450; Region: p450; cl12078 713604021132 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 713604021133 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 713604021134 Right handed beta helix region; Region: Beta_helix; pfam13229 713604021135 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604021136 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604021137 putative sugar binding sites [chemical binding]; other site 713604021138 Q-X-W motif; other site 713604021139 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604021140 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604021141 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604021142 alpha-galactosidase; Region: PLN02808; cl17638 713604021143 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604021144 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604021145 putative sugar binding sites [chemical binding]; other site 713604021146 Q-X-W motif; other site 713604021147 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604021148 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604021149 putative sugar binding sites [chemical binding]; other site 713604021150 Q-X-W motif; other site 713604021151 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 713604021152 active site 713604021153 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 713604021154 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 713604021155 Interdomain contacts; other site 713604021156 Cytokine receptor motif; other site 713604021157 Cellulose binding domain; Region: CBM_2; cl17741 713604021158 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604021159 MarR family; Region: MarR_2; pfam12802 713604021160 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604021161 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604021162 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 713604021163 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 713604021164 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 713604021165 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604021166 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604021167 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604021168 putative sugar binding sites [chemical binding]; other site 713604021169 Q-X-W motif; other site 713604021170 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604021171 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604021172 putative sugar binding sites [chemical binding]; other site 713604021173 Q-X-W motif; other site 713604021174 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 713604021175 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 713604021176 Cellulose binding domain; Region: CBM_2; pfam00553 713604021177 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604021178 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604021179 DNA binding residues [nucleotide binding] 713604021180 dimer interface [polypeptide binding]; other site 713604021181 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 713604021182 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604021183 Mg2+ binding site [ion binding]; other site 713604021184 G-X-G motif; other site 713604021185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604021186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604021187 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604021188 hypothetical protein; Provisional; Region: PRK07236 713604021189 hypothetical protein; Provisional; Region: PRK07588 713604021190 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 713604021191 mce related protein; Region: MCE; pfam02470 713604021192 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604021193 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604021194 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 713604021195 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 713604021196 Methyltransferase domain; Region: Methyltransf_11; pfam08241 713604021197 PAC2 family; Region: PAC2; pfam09754 713604021198 Uncharacterized conserved protein [Function unknown]; Region: COG3402 713604021199 Bacterial PH domain; Region: DUF304; pfam03703 713604021200 Bacterial PH domain; Region: DUF304; pfam03703 713604021201 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 713604021202 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604021203 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 713604021204 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604021205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604021206 Coenzyme A binding pocket [chemical binding]; other site 713604021207 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604021208 active site 713604021209 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604021210 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 713604021211 inhibitor-cofactor binding pocket; inhibition site 713604021212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021213 catalytic residue [active] 713604021214 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 713604021215 CoA-transferase family III; Region: CoA_transf_3; pfam02515 713604021216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604021217 putative DNA binding site [nucleotide binding]; other site 713604021218 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604021219 putative Zn2+ binding site [ion binding]; other site 713604021220 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604021221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604021222 DNA-binding site [nucleotide binding]; DNA binding site 713604021223 FCD domain; Region: FCD; pfam07729 713604021224 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 713604021225 classical (c) SDRs; Region: SDR_c; cd05233 713604021226 NAD(P) binding site [chemical binding]; other site 713604021227 active site 713604021228 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 713604021229 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 713604021230 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 713604021231 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 713604021232 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 713604021233 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 713604021234 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604021235 PYR/PP interface [polypeptide binding]; other site 713604021236 dimer interface [polypeptide binding]; other site 713604021237 TPP binding site [chemical binding]; other site 713604021238 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604021239 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 713604021240 TPP-binding site [chemical binding]; other site 713604021241 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 713604021242 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 713604021243 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 713604021244 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 713604021245 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 713604021246 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 713604021247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604021248 FeS/SAM binding site; other site 713604021249 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 713604021250 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 713604021251 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 713604021252 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604021253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604021254 proline racemase; Provisional; Region: PRK13969 713604021255 putative amidase; Provisional; Region: PRK06169 713604021256 Amidase; Region: Amidase; pfam01425 713604021257 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 713604021258 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 713604021259 NAD binding site [chemical binding]; other site 713604021260 ligand binding site [chemical binding]; other site 713604021261 catalytic site [active] 713604021262 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 713604021263 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 713604021264 Transcriptional regulators [Transcription]; Region: GntR; COG1802 713604021265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604021266 DNA-binding site [nucleotide binding]; DNA binding site 713604021267 FCD domain; Region: FCD; pfam07729 713604021268 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 713604021269 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 713604021270 tartrate dehydrogenase; Region: TTC; TIGR02089 713604021271 succinic semialdehyde dehydrogenase; Region: PLN02278 713604021272 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 713604021273 tetramerization interface [polypeptide binding]; other site 713604021274 NAD(P) binding site [chemical binding]; other site 713604021275 catalytic residues [active] 713604021276 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 713604021277 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604021278 inhibitor-cofactor binding pocket; inhibition site 713604021279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021280 catalytic residue [active] 713604021281 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 713604021282 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604021283 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604021284 active site 713604021285 catalytic tetrad [active] 713604021286 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604021287 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604021288 FAD binding domain; Region: FAD_binding_4; pfam01565 713604021289 hypothetical protein; Validated; Region: PRK07586 713604021290 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604021291 PYR/PP interface [polypeptide binding]; other site 713604021292 dimer interface [polypeptide binding]; other site 713604021293 TPP binding site [chemical binding]; other site 713604021294 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 713604021295 TPP-binding site [chemical binding]; other site 713604021296 dimer interface [polypeptide binding]; other site 713604021297 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604021298 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604021299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604021300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604021301 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 713604021302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604021303 Histidine kinase; Region: HisKA_3; pfam07730 713604021304 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604021305 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604021306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604021307 active site 713604021308 phosphorylation site [posttranslational modification] 713604021309 intermolecular recognition site; other site 713604021310 dimerization interface [polypeptide binding]; other site 713604021311 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604021312 DNA binding residues [nucleotide binding] 713604021313 dimerization interface [polypeptide binding]; other site 713604021314 MMPL family; Region: MMPL; pfam03176 713604021315 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604021316 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604021317 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 713604021318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604021319 substrate binding site [chemical binding]; other site 713604021320 oxyanion hole (OAH) forming residues; other site 713604021321 trimer interface [polypeptide binding]; other site 713604021322 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604021323 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604021324 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 713604021325 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604021326 dimer interface [polypeptide binding]; other site 713604021327 active site 713604021328 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604021329 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604021330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604021331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604021332 HEXXH motif domain; Region: mod_HExxH; TIGR04267 713604021333 TPR repeat; Region: TPR_11; pfam13414 713604021334 NB-ARC domain; Region: NB-ARC; pfam00931 713604021335 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604021336 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604021337 Tetratricopeptide repeat; Region: TPR_10; pfam13374 713604021338 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604021339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604021340 Walker A motif; other site 713604021341 ATP binding site [chemical binding]; other site 713604021342 Walker B motif; other site 713604021343 cyclase homology domain; Region: CHD; cd07302 713604021344 nucleotidyl binding site; other site 713604021345 metal binding site [ion binding]; metal-binding site 713604021346 dimer interface [polypeptide binding]; other site 713604021347 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 713604021348 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 713604021349 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604021350 active site 713604021351 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604021352 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604021353 active site 713604021354 putative transposase OrfB; Reviewed; Region: PHA02517 713604021355 HTH-like domain; Region: HTH_21; pfam13276 713604021356 Integrase core domain; Region: rve; pfam00665 713604021357 Integrase core domain; Region: rve_3; pfam13683 713604021358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604021359 Transposase; Region: HTH_Tnp_1; cl17663 713604021360 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604021361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604021362 non-specific DNA binding site [nucleotide binding]; other site 713604021363 salt bridge; other site 713604021364 sequence-specific DNA binding site [nucleotide binding]; other site 713604021365 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 713604021366 nudix motif; other site 713604021367 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604021368 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 713604021369 short chain dehydrogenase; Provisional; Region: PRK06181 713604021370 classical (c) SDRs; Region: SDR_c; cd05233 713604021371 NAD(P) binding site [chemical binding]; other site 713604021372 active site 713604021373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604021374 Coenzyme A binding pocket [chemical binding]; other site 713604021375 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 713604021376 active site 713604021377 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 713604021378 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604021379 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604021380 active site 713604021381 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 713604021382 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 713604021383 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 713604021384 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 713604021385 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 713604021386 carboxyltransferase (CT) interaction site; other site 713604021387 biotinylation site [posttranslational modification]; other site 713604021388 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 713604021389 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604021390 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 713604021391 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 713604021392 active site 713604021393 oxyanion hole [active] 713604021394 catalytic triad [active] 713604021395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604021396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604021397 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 713604021398 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 713604021399 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 713604021400 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 713604021401 homodimer interface [polypeptide binding]; other site 713604021402 substrate-cofactor binding pocket; other site 713604021403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021404 catalytic residue [active] 713604021405 FAD binding domain; Region: FAD_binding_3; pfam01494 713604021406 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604021407 hypothetical protein; Provisional; Region: PRK07236 713604021408 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 713604021409 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604021410 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604021411 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604021412 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 713604021413 putative dimer interface [polypeptide binding]; other site 713604021414 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604021415 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604021416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604021417 S-adenosylmethionine binding site [chemical binding]; other site 713604021418 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 713604021419 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 713604021420 active site 713604021421 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604021422 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604021423 NAD(P) binding site [chemical binding]; other site 713604021424 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 713604021425 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 713604021426 hexamer interface [polypeptide binding]; other site 713604021427 ligand binding site [chemical binding]; other site 713604021428 putative active site [active] 713604021429 NAD(P) binding site [chemical binding]; other site 713604021430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604021431 ATP binding site [chemical binding]; other site 713604021432 G-X-G motif; other site 713604021433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604021434 dimerization interface [polypeptide binding]; other site 713604021435 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604021436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604021437 active site 713604021438 phosphorylation site [posttranslational modification] 713604021439 intermolecular recognition site; other site 713604021440 dimerization interface [polypeptide binding]; other site 713604021441 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604021442 DNA binding site [nucleotide binding] 713604021443 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604021444 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 713604021445 Walker A/P-loop; other site 713604021446 ATP binding site [chemical binding]; other site 713604021447 Q-loop/lid; other site 713604021448 ABC transporter signature motif; other site 713604021449 Walker B; other site 713604021450 D-loop; other site 713604021451 H-loop/switch region; other site 713604021452 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 713604021453 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604021454 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604021455 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604021456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021457 Walker A/P-loop; other site 713604021458 ATP binding site [chemical binding]; other site 713604021459 Q-loop/lid; other site 713604021460 ABC transporter signature motif; other site 713604021461 Walker B; other site 713604021462 D-loop; other site 713604021463 H-loop/switch region; other site 713604021464 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604021465 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604021466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021467 Walker A/P-loop; other site 713604021468 ATP binding site [chemical binding]; other site 713604021469 Q-loop/lid; other site 713604021470 ABC transporter signature motif; other site 713604021471 Walker B; other site 713604021472 D-loop; other site 713604021473 H-loop/switch region; other site 713604021474 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 713604021475 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 713604021476 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 713604021477 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 713604021478 TPP-binding site [chemical binding]; other site 713604021479 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 713604021480 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604021481 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604021482 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 713604021483 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 713604021484 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604021485 active site 713604021486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604021487 Coenzyme A binding pocket [chemical binding]; other site 713604021488 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 713604021489 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604021490 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604021491 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 713604021492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021493 dimer interface [polypeptide binding]; other site 713604021494 ABC-ATPase subunit interface; other site 713604021495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021496 dimer interface [polypeptide binding]; other site 713604021497 conserved gate region; other site 713604021498 putative PBP binding loops; other site 713604021499 ABC-ATPase subunit interface; other site 713604021500 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 713604021501 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 713604021502 Walker A/P-loop; other site 713604021503 ATP binding site [chemical binding]; other site 713604021504 Q-loop/lid; other site 713604021505 ABC transporter signature motif; other site 713604021506 Walker B; other site 713604021507 D-loop; other site 713604021508 H-loop/switch region; other site 713604021509 Protein of unknown function DUF43; Region: DUF43; pfam01861 713604021510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604021511 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 713604021512 Malic enzyme, N-terminal domain; Region: malic; pfam00390 713604021513 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 713604021514 NAD(P) binding pocket [chemical binding]; other site 713604021515 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 713604021516 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 713604021517 hydrophobic ligand binding site; other site 713604021518 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604021519 CoenzymeA binding site [chemical binding]; other site 713604021520 subunit interaction site [polypeptide binding]; other site 713604021521 PHB binding site; other site 713604021522 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604021523 catalytic core [active] 713604021524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604021525 Coenzyme A binding pocket [chemical binding]; other site 713604021526 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 713604021527 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 713604021528 Transcription factor WhiB; Region: Whib; pfam02467 713604021529 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 713604021530 PAS fold; Region: PAS_4; pfam08448 713604021531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 713604021532 Histidine kinase; Region: HisKA_2; pfam07568 713604021533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604021534 ATP binding site [chemical binding]; other site 713604021535 Mg2+ binding site [ion binding]; other site 713604021536 G-X-G motif; other site 713604021537 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 713604021538 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 713604021539 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604021540 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604021541 DNA binding residues [nucleotide binding] 713604021542 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 713604021543 putative deacylase active site [active] 713604021544 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 713604021545 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 713604021546 Predicted GTPases [General function prediction only]; Region: COG1162 713604021547 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 713604021548 GTPase/Zn-binding domain interface [polypeptide binding]; other site 713604021549 GTP/Mg2+ binding site [chemical binding]; other site 713604021550 G4 box; other site 713604021551 G5 box; other site 713604021552 G1 box; other site 713604021553 Switch I region; other site 713604021554 G2 box; other site 713604021555 G3 box; other site 713604021556 Switch II region; other site 713604021557 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 713604021558 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 713604021559 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 713604021560 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 713604021561 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 713604021562 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 713604021563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604021564 active site 713604021565 motif I; other site 713604021566 motif II; other site 713604021567 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604021568 Cytochrome P450; Region: p450; cl12078 713604021569 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 713604021570 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 713604021571 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 713604021572 30S subunit binding site; other site 713604021573 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 713604021574 lipoprotein LpqB; Provisional; Region: PRK13615 713604021575 Sporulation and spore germination; Region: Germane; pfam10646 713604021576 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 713604021577 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 713604021578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604021579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604021580 dimer interface [polypeptide binding]; other site 713604021581 phosphorylation site [posttranslational modification] 713604021582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604021583 ATP binding site [chemical binding]; other site 713604021584 Mg2+ binding site [ion binding]; other site 713604021585 G-X-G motif; other site 713604021586 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604021587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604021588 active site 713604021589 phosphorylation site [posttranslational modification] 713604021590 intermolecular recognition site; other site 713604021591 dimerization interface [polypeptide binding]; other site 713604021592 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604021593 DNA binding site [nucleotide binding] 713604021594 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 713604021595 [2Fe-2S] cluster binding site [ion binding]; other site 713604021596 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 713604021597 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604021598 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604021599 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604021600 HTH domain; Region: HTH_11; pfam08279 713604021601 WYL domain; Region: WYL; pfam13280 713604021602 FAD dependent oxidoreductase; Region: DAO; pfam01266 713604021603 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604021604 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 713604021605 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 713604021606 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 713604021607 thymidylate kinase; Validated; Region: PRK07933 713604021608 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 713604021609 putative active site [active] 713604021610 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 713604021611 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 713604021612 putative active site [active] 713604021613 HicB family; Region: HicB; pfam05534 713604021614 Adenosylhomocysteinase; Provisional; Region: PTZ00075 713604021615 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 713604021616 homotetramer interface [polypeptide binding]; other site 713604021617 ligand binding site [chemical binding]; other site 713604021618 catalytic site [active] 713604021619 NAD binding site [chemical binding]; other site 713604021620 amino acid transporter; Region: 2A0306; TIGR00909 713604021621 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 713604021622 Cation efflux family; Region: Cation_efflux; pfam01545 713604021623 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604021624 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604021625 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 713604021626 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 713604021627 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 713604021628 Trm112p-like protein; Region: Trm112p; cl01066 713604021629 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 713604021630 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 713604021631 active site 713604021632 substrate binding site [chemical binding]; other site 713604021633 metal binding site [ion binding]; metal-binding site 713604021634 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 713604021635 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 713604021636 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 713604021637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604021638 active site 713604021639 Transcription factor WhiB; Region: Whib; pfam02467 713604021640 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 713604021641 active site 713604021642 putative substrate binding region [chemical binding]; other site 713604021643 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 713604021644 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 713604021645 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604021646 Walker A/P-loop; other site 713604021647 ATP binding site [chemical binding]; other site 713604021648 Q-loop/lid; other site 713604021649 ABC transporter signature motif; other site 713604021650 Walker B; other site 713604021651 D-loop; other site 713604021652 H-loop/switch region; other site 713604021653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604021654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604021655 Walker A/P-loop; other site 713604021656 ATP binding site [chemical binding]; other site 713604021657 Q-loop/lid; other site 713604021658 ABC transporter signature motif; other site 713604021659 Walker B; other site 713604021660 D-loop; other site 713604021661 H-loop/switch region; other site 713604021662 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604021663 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604021664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021665 dimer interface [polypeptide binding]; other site 713604021666 conserved gate region; other site 713604021667 putative PBP binding loops; other site 713604021668 ABC-ATPase subunit interface; other site 713604021669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604021670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021671 dimer interface [polypeptide binding]; other site 713604021672 conserved gate region; other site 713604021673 putative PBP binding loops; other site 713604021674 ABC-ATPase subunit interface; other site 713604021675 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604021676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021677 putative PBP binding loops; other site 713604021678 dimer interface [polypeptide binding]; other site 713604021679 ABC-ATPase subunit interface; other site 713604021680 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 713604021681 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 713604021682 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 713604021683 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 713604021684 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 713604021685 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 713604021686 G1 box; other site 713604021687 putative GEF interaction site [polypeptide binding]; other site 713604021688 GTP/Mg2+ binding site [chemical binding]; other site 713604021689 Switch I region; other site 713604021690 G2 box; other site 713604021691 G3 box; other site 713604021692 Switch II region; other site 713604021693 G4 box; other site 713604021694 G5 box; other site 713604021695 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 713604021696 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 713604021697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 713604021698 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 713604021699 active site 713604021700 HIGH motif; other site 713604021701 dimer interface [polypeptide binding]; other site 713604021702 KMSKS motif; other site 713604021703 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 713604021704 nudix motif; other site 713604021705 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604021706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604021707 dimer interface [polypeptide binding]; other site 713604021708 phosphorylation site [posttranslational modification] 713604021709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604021710 ATP binding site [chemical binding]; other site 713604021711 Mg2+ binding site [ion binding]; other site 713604021712 G-X-G motif; other site 713604021713 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604021714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604021715 active site 713604021716 phosphorylation site [posttranslational modification] 713604021717 intermolecular recognition site; other site 713604021718 dimerization interface [polypeptide binding]; other site 713604021719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604021720 DNA binding site [nucleotide binding] 713604021721 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 713604021722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021723 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604021724 Walker A/P-loop; other site 713604021725 ATP binding site [chemical binding]; other site 713604021726 Q-loop/lid; other site 713604021727 ABC transporter signature motif; other site 713604021728 Walker B; other site 713604021729 D-loop; other site 713604021730 H-loop/switch region; other site 713604021731 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 713604021732 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 713604021733 Walker A/P-loop; other site 713604021734 ATP binding site [chemical binding]; other site 713604021735 Q-loop/lid; other site 713604021736 ABC transporter signature motif; other site 713604021737 Walker B; other site 713604021738 D-loop; other site 713604021739 H-loop/switch region; other site 713604021740 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 713604021741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604021742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021743 dimer interface [polypeptide binding]; other site 713604021744 conserved gate region; other site 713604021745 putative PBP binding loops; other site 713604021746 ABC-ATPase subunit interface; other site 713604021747 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 713604021748 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604021749 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 713604021750 aromatic arch; other site 713604021751 DCoH dimer interaction site [polypeptide binding]; other site 713604021752 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 713604021753 DCoH tetramer interaction site [polypeptide binding]; other site 713604021754 substrate binding site [chemical binding]; other site 713604021755 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 713604021756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604021757 putative DNA binding site [nucleotide binding]; other site 713604021758 putative Zn2+ binding site [ion binding]; other site 713604021759 GTP-binding protein YchF; Reviewed; Region: PRK09601 713604021760 YchF GTPase; Region: YchF; cd01900 713604021761 G1 box; other site 713604021762 GTP/Mg2+ binding site [chemical binding]; other site 713604021763 Switch I region; other site 713604021764 G2 box; other site 713604021765 Switch II region; other site 713604021766 G3 box; other site 713604021767 G4 box; other site 713604021768 G5 box; other site 713604021769 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 713604021770 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 713604021771 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 713604021772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604021773 AlkA N-terminal domain; Region: AlkA_N; pfam06029 713604021774 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 713604021775 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 713604021776 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 713604021777 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 713604021778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021779 Walker A/P-loop; other site 713604021780 ATP binding site [chemical binding]; other site 713604021781 Q-loop/lid; other site 713604021782 ABC transporter signature motif; other site 713604021783 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 713604021784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021785 Walker B; other site 713604021786 D-loop; other site 713604021787 H-loop/switch region; other site 713604021788 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 713604021789 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604021790 active site 713604021791 metal binding site [ion binding]; metal-binding site 713604021792 DNA binding site [nucleotide binding] 713604021793 RmuC family; Region: RmuC; pfam02646 713604021794 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 713604021795 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 713604021796 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 713604021797 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 713604021798 generic binding surface II; other site 713604021799 generic binding surface I; other site 713604021800 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 713604021801 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 713604021802 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 713604021803 putative active site [active] 713604021804 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 713604021805 active site 713604021806 substrate binding sites [chemical binding]; other site 713604021807 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 713604021808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604021809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604021810 fumarate hydratase; Reviewed; Region: fumC; PRK00485 713604021811 Class II fumarases; Region: Fumarase_classII; cd01362 713604021812 active site 713604021813 tetramer interface [polypeptide binding]; other site 713604021814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604021815 salt bridge; other site 713604021816 non-specific DNA binding site [nucleotide binding]; other site 713604021817 sequence-specific DNA binding site [nucleotide binding]; other site 713604021818 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 713604021819 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 713604021820 active site 713604021821 DNA binding site [nucleotide binding] 713604021822 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 713604021823 DNA binding site [nucleotide binding] 713604021824 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604021825 Domain of unknown function (DUF309); Region: DUF309; pfam03745 713604021826 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 713604021827 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 713604021828 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604021829 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 713604021830 phosphate binding site [ion binding]; other site 713604021831 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604021832 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 713604021833 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 713604021834 putative active site [active] 713604021835 PhoH-like protein; Region: PhoH; pfam02562 713604021836 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 713604021837 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 713604021838 catalytic residue [active] 713604021839 putative FPP diphosphate binding site; other site 713604021840 putative FPP binding hydrophobic cleft; other site 713604021841 dimer interface [polypeptide binding]; other site 713604021842 putative IPP diphosphate binding site; other site 713604021843 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 713604021844 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 713604021845 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604021846 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 713604021847 PRC-barrel domain; Region: PRC; pfam05239 713604021848 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 713604021849 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604021850 acyl-coenzyme A oxidase; Region: PLN02636 713604021851 active site 713604021852 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 713604021853 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 713604021854 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 713604021855 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 713604021856 catalytic residues [active] 713604021857 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 713604021858 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 713604021859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604021860 S-adenosylmethionine binding site [chemical binding]; other site 713604021861 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 713604021862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604021863 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 713604021864 active site 713604021865 Walker A/P-loop; other site 713604021866 ATP binding site [chemical binding]; other site 713604021867 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 713604021868 active site 713604021869 metal binding site [ion binding]; metal-binding site 713604021870 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 713604021871 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 713604021872 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 713604021873 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 713604021874 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 713604021875 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604021876 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 713604021877 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604021878 AsnC family; Region: AsnC_trans_reg; pfam01037 713604021879 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 713604021880 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 713604021881 dimer interface [polypeptide binding]; other site 713604021882 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 713604021883 active site 713604021884 Fe binding site [ion binding]; other site 713604021885 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 713604021886 threonine dehydratase; Provisional; Region: PRK08198 713604021887 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 713604021888 tetramer interface [polypeptide binding]; other site 713604021889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021890 catalytic residue [active] 713604021891 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 713604021892 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604021893 cystathionine gamma-synthase; Provisional; Region: PRK07811 713604021894 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 713604021895 homodimer interface [polypeptide binding]; other site 713604021896 substrate-cofactor binding pocket; other site 713604021897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021898 catalytic residue [active] 713604021899 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 713604021900 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 713604021901 dimer interface [polypeptide binding]; other site 713604021902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604021903 catalytic residue [active] 713604021904 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 713604021905 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 713604021906 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604021907 dimer interface [polypeptide binding]; other site 713604021908 active site 713604021909 Bax inhibitor 1 like; Region: BaxI_1; cl17691 713604021910 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 713604021911 active site 713604021912 putative catalytic site [active] 713604021913 short chain dehydrogenase; Provisional; Region: PRK07201 713604021914 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 713604021915 putative NAD(P) binding site [chemical binding]; other site 713604021916 active site 713604021917 putative substrate binding site [chemical binding]; other site 713604021918 classical (c) SDRs; Region: SDR_c; cd05233 713604021919 NAD(P) binding site [chemical binding]; other site 713604021920 active site 713604021921 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 713604021922 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604021923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604021924 DNA binding residues [nucleotide binding] 713604021925 dimerization interface [polypeptide binding]; other site 713604021926 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 713604021927 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 713604021928 DNA binding site [nucleotide binding] 713604021929 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604021930 AAA ATPase domain; Region: AAA_16; pfam13191 713604021931 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604021932 DNA binding site [nucleotide binding] 713604021933 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604021934 AAA ATPase domain; Region: AAA_16; pfam13191 713604021935 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604021936 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604021937 DNA binding residues [nucleotide binding] 713604021938 dimerization interface [polypeptide binding]; other site 713604021939 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604021940 beta-galactosidase; Region: BGL; TIGR03356 713604021941 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604021942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021943 dimer interface [polypeptide binding]; other site 713604021944 conserved gate region; other site 713604021945 putative PBP binding loops; other site 713604021946 ABC-ATPase subunit interface; other site 713604021947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604021948 dimer interface [polypeptide binding]; other site 713604021949 putative PBP binding loops; other site 713604021950 ABC-ATPase subunit interface; other site 713604021951 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 713604021952 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604021953 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604021954 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604021955 DNA binding residues [nucleotide binding] 713604021956 dimerization interface [polypeptide binding]; other site 713604021957 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604021958 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 713604021959 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604021960 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604021961 active site 713604021962 catalytic tetrad [active] 713604021963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604021964 putative substrate translocation pore; other site 713604021965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604021966 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604021967 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604021968 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604021969 AsnC family; Region: AsnC_trans_reg; pfam01037 713604021970 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 713604021971 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604021972 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 713604021973 aromatic chitin/cellulose binding site residues [chemical binding]; other site 713604021974 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 713604021975 putative sugar binding site [chemical binding]; other site 713604021976 catalytic residues [active] 713604021977 Thioesterase domain; Region: Thioesterase; pfam00975 713604021978 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 713604021979 active site 713604021980 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 713604021981 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604021982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604021983 TQXA domain; Region: TQXA_dom; TIGR03934 713604021984 Cellulose binding domain; Region: CBM_2; pfam00553 713604021985 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604021986 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 713604021987 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604021988 G1 box; other site 713604021989 GTP/Mg2+ binding site [chemical binding]; other site 713604021990 G2 box; other site 713604021991 Switch I region; other site 713604021992 G3 box; other site 713604021993 Switch II region; other site 713604021994 G4 box; other site 713604021995 G5 box; other site 713604021996 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 713604021997 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 713604021998 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 713604021999 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 713604022000 Phosphotransferase enzyme family; Region: APH; pfam01636 713604022001 putative active site [active] 713604022002 putative substrate binding site [chemical binding]; other site 713604022003 ATP binding site [chemical binding]; other site 713604022004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604022005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604022006 dimerization interface [polypeptide binding]; other site 713604022007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604022008 dimer interface [polypeptide binding]; other site 713604022009 phosphorylation site [posttranslational modification] 713604022010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022011 ATP binding site [chemical binding]; other site 713604022012 Mg2+ binding site [ion binding]; other site 713604022013 G-X-G motif; other site 713604022014 enolase; Provisional; Region: eno; PRK00077 713604022015 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 713604022016 dimer interface [polypeptide binding]; other site 713604022017 metal binding site [ion binding]; metal-binding site 713604022018 substrate binding pocket [chemical binding]; other site 713604022019 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 713604022020 Catalytic site [active] 713604022021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604022022 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604022023 Walker A/P-loop; other site 713604022024 ATP binding site [chemical binding]; other site 713604022025 Q-loop/lid; other site 713604022026 ABC transporter signature motif; other site 713604022027 Walker B; other site 713604022028 D-loop; other site 713604022029 H-loop/switch region; other site 713604022030 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604022031 AAA ATPase domain; Region: AAA_16; pfam13191 713604022032 AAA domain; Region: AAA_22; pfam13401 713604022033 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604022034 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604022035 TPR motif; other site 713604022036 binding surface 713604022037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604022038 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604022039 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 713604022040 active site 713604022041 catalytic triad [active] 713604022042 oxyanion hole [active] 713604022043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 713604022044 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604022045 Predicted ATPase [General function prediction only]; Region: COG3903 713604022046 hypothetical protein; Provisional; Region: PRK06834 713604022047 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 713604022048 AAA ATPase domain; Region: AAA_16; pfam13191 713604022049 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604022050 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604022051 DNA binding residues [nucleotide binding] 713604022052 dimerization interface [polypeptide binding]; other site 713604022053 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 713604022054 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 713604022055 AAA ATPase domain; Region: AAA_16; pfam13191 713604022056 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 713604022057 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 713604022058 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 713604022059 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604022060 TIR domain; Region: TIR_2; pfam13676 713604022061 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604022062 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 713604022063 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 713604022064 HEXXH motif domain; Region: mod_HExxH; TIGR04267 713604022065 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604022066 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604022067 DNA binding residues [nucleotide binding] 713604022068 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604022069 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604022070 active site 713604022071 ATP binding site [chemical binding]; other site 713604022072 substrate binding site [chemical binding]; other site 713604022073 activation loop (A-loop); other site 713604022074 PemK-like protein; Region: PemK; pfam02452 713604022075 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604022076 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 713604022077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022079 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604022080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604022081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604022082 DNA binding residues [nucleotide binding] 713604022083 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 713604022084 active site 713604022085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604022086 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604022087 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604022088 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 713604022089 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 713604022090 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 713604022091 nudix motif; other site 713604022092 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 713604022093 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 713604022094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604022095 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 713604022096 Fe-S cluster binding site [ion binding]; other site 713604022097 DNA binding site [nucleotide binding] 713604022098 active site 713604022099 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 713604022100 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 713604022101 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 713604022102 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604022103 active site 713604022104 catalytic residues [active] 713604022105 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604022106 catalytic residues [active] 713604022107 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 713604022108 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604022109 Walker A/P-loop; other site 713604022110 ATP binding site [chemical binding]; other site 713604022111 Q-loop/lid; other site 713604022112 ABC transporter signature motif; other site 713604022113 Walker B; other site 713604022114 D-loop; other site 713604022115 H-loop/switch region; other site 713604022116 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 713604022117 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604022118 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604022119 Walker A/P-loop; other site 713604022120 ATP binding site [chemical binding]; other site 713604022121 Q-loop/lid; other site 713604022122 ABC transporter signature motif; other site 713604022123 Walker B; other site 713604022124 D-loop; other site 713604022125 H-loop/switch region; other site 713604022126 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 713604022127 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 713604022128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022129 dimer interface [polypeptide binding]; other site 713604022130 conserved gate region; other site 713604022131 putative PBP binding loops; other site 713604022132 ABC-ATPase subunit interface; other site 713604022133 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604022134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022135 dimer interface [polypeptide binding]; other site 713604022136 conserved gate region; other site 713604022137 putative PBP binding loops; other site 713604022138 ABC-ATPase subunit interface; other site 713604022139 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 713604022140 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 713604022141 exopolyphosphatase; Region: exo_poly_only; TIGR03706 713604022142 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 713604022143 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604022144 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604022145 Protein of unknown function (DUF501); Region: DUF501; cl00652 713604022146 Septum formation initiator; Region: DivIC; cl17659 713604022147 enolase; Provisional; Region: eno; PRK00077 713604022148 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 713604022149 dimer interface [polypeptide binding]; other site 713604022150 metal binding site [ion binding]; metal-binding site 713604022151 substrate binding pocket [chemical binding]; other site 713604022152 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 713604022153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604022154 binding surface 713604022155 TPR motif; other site 713604022156 TPR repeat; Region: TPR_11; pfam13414 713604022157 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 713604022158 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604022159 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604022160 Iron permease FTR1 family; Region: FTR1; cl00475 713604022161 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 713604022162 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 713604022163 Imelysin; Region: Peptidase_M75; pfam09375 713604022164 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 713604022165 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 713604022166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022167 WHG domain; Region: WHG; pfam13305 713604022168 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 713604022169 active site 713604022170 catalytic triad [active] 713604022171 oxyanion hole [active] 713604022172 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 713604022173 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 713604022174 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 713604022175 Walker A/P-loop; other site 713604022176 ATP binding site [chemical binding]; other site 713604022177 Q-loop/lid; other site 713604022178 ABC transporter signature motif; other site 713604022179 Walker B; other site 713604022180 D-loop; other site 713604022181 H-loop/switch region; other site 713604022182 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604022183 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604022184 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 713604022185 homodimer interface [polypeptide binding]; other site 713604022186 MazG family protein; Region: mazG; TIGR00444 713604022187 metal binding site [ion binding]; metal-binding site 713604022188 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 713604022189 SurA N-terminal domain; Region: SurA_N_3; cl07813 713604022190 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 713604022191 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 713604022192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604022193 ATP binding site [chemical binding]; other site 713604022194 putative Mg++ binding site [ion binding]; other site 713604022195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604022196 nucleotide binding region [chemical binding]; other site 713604022197 ATP-binding site [chemical binding]; other site 713604022198 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 713604022199 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 713604022200 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604022201 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604022202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604022203 non-specific DNA binding site [nucleotide binding]; other site 713604022204 salt bridge; other site 713604022205 sequence-specific DNA binding site [nucleotide binding]; other site 713604022206 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604022207 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604022208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604022209 S-adenosylmethionine binding site [chemical binding]; other site 713604022210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604022211 Histidine kinase; Region: HisKA_3; pfam07730 713604022212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022213 ATP binding site [chemical binding]; other site 713604022214 Mg2+ binding site [ion binding]; other site 713604022215 G-X-G motif; other site 713604022216 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604022217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022218 active site 713604022219 phosphorylation site [posttranslational modification] 713604022220 intermolecular recognition site; other site 713604022221 dimerization interface [polypeptide binding]; other site 713604022222 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604022223 DNA binding residues [nucleotide binding] 713604022224 dimerization interface [polypeptide binding]; other site 713604022225 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604022226 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604022227 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 713604022228 classical (c) SDRs; Region: SDR_c; cd05233 713604022229 NAD(P) binding site [chemical binding]; other site 713604022230 active site 713604022231 Isochorismatase family; Region: Isochorismatase; pfam00857 713604022232 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 713604022233 catalytic triad [active] 713604022234 conserved cis-peptide bond; other site 713604022235 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 713604022236 nudix motif; other site 713604022237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022239 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604022240 Fatty acid desaturase; Region: FA_desaturase; pfam00487 713604022241 Di-iron ligands [ion binding]; other site 713604022242 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 713604022243 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604022244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604022245 metal binding site [ion binding]; metal-binding site 713604022246 active site 713604022247 I-site; other site 713604022248 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 713604022249 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 713604022250 Substrate binding site; other site 713604022251 Mg++ binding site; other site 713604022252 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 713604022253 active site 713604022254 substrate binding site [chemical binding]; other site 713604022255 CoA binding site [chemical binding]; other site 713604022256 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 713604022257 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 713604022258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604022259 active site 713604022260 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604022261 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604022262 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 713604022263 NADH(P)-binding; Region: NAD_binding_10; pfam13460 713604022264 NAD binding site [chemical binding]; other site 713604022265 substrate binding site [chemical binding]; other site 713604022266 putative active site [active] 713604022267 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 713604022268 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 713604022269 5S rRNA interface [nucleotide binding]; other site 713604022270 CTC domain interface [polypeptide binding]; other site 713604022271 L16 interface [polypeptide binding]; other site 713604022272 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 713604022273 putative active site [active] 713604022274 catalytic residue [active] 713604022275 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604022276 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604022277 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604022278 DivIVA domain; Region: DivI1A_domain; TIGR03544 713604022279 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 713604022280 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 713604022281 acyl-activating enzyme (AAE) consensus motif; other site 713604022282 active site 713604022283 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 713604022284 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604022285 ABC transporter; Region: ABC_tran_2; pfam12848 713604022286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 713604022287 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 713604022288 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 713604022289 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 713604022290 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 713604022291 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 713604022292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604022293 Walker A/P-loop; other site 713604022294 ATP binding site [chemical binding]; other site 713604022295 Q-loop/lid; other site 713604022296 ABC transporter signature motif; other site 713604022297 Walker B; other site 713604022298 D-loop; other site 713604022299 H-loop/switch region; other site 713604022300 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 713604022301 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 713604022302 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 713604022303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 713604022304 Domain of unknown function (DUF348); Region: DUF348; pfam03990 713604022305 G5 domain; Region: G5; pfam07501 713604022306 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 713604022307 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 713604022308 active site 713604022309 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 713604022310 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 713604022311 active site 713604022312 HIGH motif; other site 713604022313 KMSKS motif; other site 713604022314 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 713604022315 tRNA binding surface [nucleotide binding]; other site 713604022316 anticodon binding site; other site 713604022317 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604022318 Transcriptional regulator PadR-like family; Region: PadR; cl17335 713604022319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604022320 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604022321 Walker A/P-loop; other site 713604022322 ATP binding site [chemical binding]; other site 713604022323 Q-loop/lid; other site 713604022324 ABC transporter signature motif; other site 713604022325 Walker B; other site 713604022326 D-loop; other site 713604022327 H-loop/switch region; other site 713604022328 ABC-2 type transporter; Region: ABC2_membrane; cl17235 713604022329 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604022330 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 713604022331 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604022332 active site 713604022333 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 713604022334 chorismate binding enzyme; Region: Chorismate_bind; cl10555 713604022335 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604022336 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604022337 NAD(P) binding site [chemical binding]; other site 713604022338 Predicted methyltransferases [General function prediction only]; Region: COG0313 713604022339 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 713604022340 putative SAM binding site [chemical binding]; other site 713604022341 putative homodimer interface [polypeptide binding]; other site 713604022342 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 713604022343 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 713604022344 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 713604022345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604022346 S-adenosylmethionine binding site [chemical binding]; other site 713604022347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604022348 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604022349 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604022350 active site 713604022351 ATP binding site [chemical binding]; other site 713604022352 substrate binding site [chemical binding]; other site 713604022353 activation loop (A-loop); other site 713604022354 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 713604022355 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 713604022356 acyl-activating enzyme (AAE) consensus motif; other site 713604022357 putative AMP binding site [chemical binding]; other site 713604022358 putative active site [active] 713604022359 putative CoA binding site [chemical binding]; other site 713604022360 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 713604022361 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 713604022362 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 713604022363 active site 713604022364 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 713604022366 MOSC domain; Region: MOSC; pfam03473 713604022367 hypothetical protein; Provisional; Region: PRK07079 713604022368 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 713604022369 metal binding site [ion binding]; metal-binding site 713604022370 putative dimer interface [polypeptide binding]; other site 713604022371 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604022372 Predicted flavoprotein [General function prediction only]; Region: COG0431 713604022373 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 713604022374 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604022375 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604022376 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604022377 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604022378 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 713604022379 active site 713604022380 catalytic triad [active] 713604022381 oxyanion hole [active] 713604022382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022383 WHG domain; Region: WHG; pfam13305 713604022384 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 713604022385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604022386 putative DNA binding site [nucleotide binding]; other site 713604022387 dimerization interface [polypeptide binding]; other site 713604022388 putative Zn2+ binding site [ion binding]; other site 713604022389 MMPL family; Region: MMPL; pfam03176 713604022390 PAS domain S-box; Region: sensory_box; TIGR00229 713604022391 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 713604022392 putative active site [active] 713604022393 heme pocket [chemical binding]; other site 713604022394 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604022395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604022396 metal binding site [ion binding]; metal-binding site 713604022397 active site 713604022398 I-site; other site 713604022399 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 713604022400 Cytochrome P450; Region: p450; pfam00067 713604022401 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604022402 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 713604022403 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604022404 P-loop; other site 713604022405 Magnesium ion binding site [ion binding]; other site 713604022406 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604022407 Magnesium ion binding site [ion binding]; other site 713604022408 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 713604022409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604022410 NmrA-like family; Region: NmrA; pfam05368 713604022411 NAD(P) binding site [chemical binding]; other site 713604022412 active site 713604022413 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 713604022414 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604022415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022416 active site 713604022417 phosphorylation site [posttranslational modification] 713604022418 intermolecular recognition site; other site 713604022419 dimerization interface [polypeptide binding]; other site 713604022420 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604022421 DNA binding site [nucleotide binding] 713604022422 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604022423 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604022424 dimerization interface [polypeptide binding]; other site 713604022425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604022426 dimer interface [polypeptide binding]; other site 713604022427 phosphorylation site [posttranslational modification] 713604022428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022429 ATP binding site [chemical binding]; other site 713604022430 Mg2+ binding site [ion binding]; other site 713604022431 G-X-G motif; other site 713604022432 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 713604022433 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 713604022434 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 713604022435 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 713604022436 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 713604022437 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 713604022438 NAD binding site [chemical binding]; other site 713604022439 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 713604022440 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604022441 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604022442 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604022443 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 713604022444 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604022445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604022446 homodimer interface [polypeptide binding]; other site 713604022447 catalytic residue [active] 713604022448 Condensation domain; Region: Condensation; pfam00668 713604022449 Nonribosomal peptide synthase; Region: NRPS; pfam08415 713604022450 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 713604022451 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 713604022452 acyl-activating enzyme (AAE) consensus motif; other site 713604022453 AMP binding site [chemical binding]; other site 713604022454 Methyltransferase domain; Region: Methyltransf_31; pfam13847 713604022455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604022456 S-adenosylmethionine binding site [chemical binding]; other site 713604022457 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604022458 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 713604022459 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 713604022460 Thioesterase domain; Region: Thioesterase; pfam00975 713604022461 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 713604022462 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604022463 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604022464 active site 713604022465 ATP binding site [chemical binding]; other site 713604022466 substrate binding site [chemical binding]; other site 713604022467 activation loop (A-loop); other site 713604022468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 713604022469 binding surface 713604022470 TPR motif; other site 713604022471 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604022472 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 713604022473 DNA-binding interface [nucleotide binding]; DNA binding site 713604022474 AIPR protein; Region: AIPR; pfam10592 713604022475 AAA ATPase domain; Region: AAA_16; pfam13191 713604022476 Domain of unknown function DUF87; Region: DUF87; pfam01935 713604022477 AAA-like domain; Region: AAA_10; pfam12846 713604022478 Zonular occludens toxin (Zot); Region: Zot; cl17485 713604022479 DEAD-like helicases superfamily; Region: DEXDc; smart00487 713604022480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604022481 ATP binding site [chemical binding]; other site 713604022482 putative Mg++ binding site [ion binding]; other site 713604022483 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 713604022484 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 713604022485 GH3 auxin-responsive promoter; Region: GH3; pfam03321 713604022486 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 713604022487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604022488 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604022489 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 713604022490 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 713604022491 dimer interface [polypeptide binding]; other site 713604022492 putative functional site; other site 713604022493 putative MPT binding site; other site 713604022494 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 713604022495 active site 713604022496 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 713604022497 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 713604022498 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 713604022499 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 713604022500 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 713604022501 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 713604022502 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 713604022503 MPT binding site; other site 713604022504 trimer interface [polypeptide binding]; other site 713604022505 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 713604022506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604022507 NAD(P) binding site [chemical binding]; other site 713604022508 active site 713604022509 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 713604022510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604022511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604022512 dimer interface [polypeptide binding]; other site 713604022513 phosphorylation site [posttranslational modification] 713604022514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022515 ATP binding site [chemical binding]; other site 713604022516 Mg2+ binding site [ion binding]; other site 713604022517 G-X-G motif; other site 713604022518 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604022519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022520 active site 713604022521 phosphorylation site [posttranslational modification] 713604022522 intermolecular recognition site; other site 713604022523 dimerization interface [polypeptide binding]; other site 713604022524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604022525 DNA binding site [nucleotide binding] 713604022526 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 713604022527 Ligand binding site; other site 713604022528 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 713604022529 Putative Catalytic site; other site 713604022530 DXD motif; other site 713604022531 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 713604022532 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 713604022533 Moco binding site; other site 713604022534 metal coordination site [ion binding]; other site 713604022535 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 713604022536 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604022537 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604022538 protein binding site [polypeptide binding]; other site 713604022539 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 713604022540 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 713604022541 dimer interface [polypeptide binding]; other site 713604022542 active site 713604022543 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 713604022544 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 713604022545 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 713604022546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604022547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604022548 dimerization interface [polypeptide binding]; other site 713604022549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604022550 dimer interface [polypeptide binding]; other site 713604022551 phosphorylation site [posttranslational modification] 713604022552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022553 ATP binding site [chemical binding]; other site 713604022554 Mg2+ binding site [ion binding]; other site 713604022555 G-X-G motif; other site 713604022556 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604022557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022558 active site 713604022559 phosphorylation site [posttranslational modification] 713604022560 intermolecular recognition site; other site 713604022561 dimerization interface [polypeptide binding]; other site 713604022562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604022563 DNA binding site [nucleotide binding] 713604022564 Predicted membrane protein [Function unknown]; Region: COG2860 713604022565 UPF0126 domain; Region: UPF0126; pfam03458 713604022566 UPF0126 domain; Region: UPF0126; pfam03458 713604022567 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604022568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022569 active site 713604022570 phosphorylation site [posttranslational modification] 713604022571 intermolecular recognition site; other site 713604022572 dimerization interface [polypeptide binding]; other site 713604022573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604022574 DNA binding residues [nucleotide binding] 713604022575 dimerization interface [polypeptide binding]; other site 713604022576 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604022577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604022578 S-adenosylmethionine binding site [chemical binding]; other site 713604022579 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604022580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604022581 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 713604022582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604022583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 713604022584 dimerization interface [polypeptide binding]; other site 713604022585 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604022586 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604022587 active site 713604022588 catalytic tetrad [active] 713604022589 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 713604022590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604022591 DNA-binding site [nucleotide binding]; DNA binding site 713604022592 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604022593 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604022594 homodimer interface [polypeptide binding]; other site 713604022595 catalytic residue [active] 713604022596 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 713604022597 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 713604022598 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604022599 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604022600 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604022601 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604022602 active site 713604022603 ATP binding site [chemical binding]; other site 713604022604 substrate binding site [chemical binding]; other site 713604022605 activation loop (A-loop); other site 713604022606 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 713604022607 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 713604022608 active site 713604022609 dimerization interface [polypeptide binding]; other site 713604022610 Creatinine amidohydrolase; Region: Creatininase; pfam02633 713604022611 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 713604022612 dimerization interface [polypeptide binding]; other site 713604022613 active site 713604022614 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 713604022615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604022616 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 713604022617 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 713604022618 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 713604022619 active site 713604022620 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 713604022621 putative NAD(P) binding site [chemical binding]; other site 713604022622 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604022623 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 713604022624 nucleotide binding site [chemical binding]; other site 713604022625 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 713604022626 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 713604022627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604022628 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 713604022629 putative dimerization interface [polypeptide binding]; other site 713604022630 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 713604022631 FAD binding domain; Region: FAD_binding_4; pfam01565 713604022632 Berberine and berberine like; Region: BBE; pfam08031 713604022633 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 713604022634 Domain of unknown function (DUF385); Region: DUF385; pfam04075 713604022635 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604022636 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604022637 putative Zn2+ binding site [ion binding]; other site 713604022638 putative DNA binding site [nucleotide binding]; other site 713604022639 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 713604022640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604022641 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604022642 PaaX-like protein; Region: PaaX; pfam07848 713604022643 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 713604022644 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 713604022645 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 713604022646 homotrimer interaction site [polypeptide binding]; other site 713604022647 putative active site [active] 713604022648 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 713604022649 hypothetical protein; Provisional; Region: PRK07236 713604022650 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 713604022651 active site 713604022652 FMN binding site [chemical binding]; other site 713604022653 substrate binding site [chemical binding]; other site 713604022654 homotetramer interface [polypeptide binding]; other site 713604022655 catalytic residue [active] 713604022656 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604022657 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604022658 active site 713604022659 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 713604022660 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 713604022661 beta-galactosidase; Region: BGL; TIGR03356 713604022662 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604022663 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604022664 Walker A/P-loop; other site 713604022665 ATP binding site [chemical binding]; other site 713604022666 Q-loop/lid; other site 713604022667 ABC transporter signature motif; other site 713604022668 Walker B; other site 713604022669 D-loop; other site 713604022670 H-loop/switch region; other site 713604022671 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604022672 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 713604022673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022674 dimer interface [polypeptide binding]; other site 713604022675 conserved gate region; other site 713604022676 putative PBP binding loops; other site 713604022677 ABC-ATPase subunit interface; other site 713604022678 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604022679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022680 dimer interface [polypeptide binding]; other site 713604022681 conserved gate region; other site 713604022682 putative PBP binding loops; other site 713604022683 ABC-ATPase subunit interface; other site 713604022684 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604022685 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604022686 Walker A/P-loop; other site 713604022687 ATP binding site [chemical binding]; other site 713604022688 Q-loop/lid; other site 713604022689 ABC transporter signature motif; other site 713604022690 Walker B; other site 713604022691 D-loop; other site 713604022692 H-loop/switch region; other site 713604022693 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604022694 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 713604022695 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 713604022696 substrate binding site [chemical binding]; other site 713604022697 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 713604022698 putative switch regulator; other site 713604022699 non-specific DNA interactions [nucleotide binding]; other site 713604022700 DNA binding site [nucleotide binding] 713604022701 sequence specific DNA binding site [nucleotide binding]; other site 713604022702 putative cAMP binding site [chemical binding]; other site 713604022703 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604022704 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604022705 nucleotide binding site [chemical binding]; other site 713604022706 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 713604022707 putative switch regulator; other site 713604022708 non-specific DNA interactions [nucleotide binding]; other site 713604022709 DNA binding site [nucleotide binding] 713604022710 sequence specific DNA binding site [nucleotide binding]; other site 713604022711 putative cAMP binding site [chemical binding]; other site 713604022712 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604022713 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 713604022714 nucleotide binding site [chemical binding]; other site 713604022715 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 713604022716 active site 713604022717 catalytic residues [active] 713604022718 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604022719 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604022720 putative sugar binding sites [chemical binding]; other site 713604022721 Q-X-W motif; other site 713604022722 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 713604022723 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604022724 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604022725 putative sugar binding sites [chemical binding]; other site 713604022726 Q-X-W motif; other site 713604022727 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 713604022728 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 713604022729 Ricin-type beta-trefoil; Region: RICIN; smart00458 713604022730 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604022731 putative sugar binding sites [chemical binding]; other site 713604022732 Q-X-W motif; other site 713604022733 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604022734 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604022735 putative sugar binding sites [chemical binding]; other site 713604022736 Q-X-W motif; other site 713604022737 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 713604022738 active site 713604022739 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 713604022740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604022741 DNA-binding site [nucleotide binding]; DNA binding site 713604022742 FCD domain; Region: FCD; pfam07729 713604022743 benzoate transport; Region: 2A0115; TIGR00895 713604022744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604022745 putative substrate translocation pore; other site 713604022746 hypothetical protein; Provisional; Region: PRK05463 713604022747 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 713604022748 putative active site [active] 713604022749 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 713604022750 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 713604022751 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 713604022752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604022753 putative DNA binding site [nucleotide binding]; other site 713604022754 dimerization interface [polypeptide binding]; other site 713604022755 putative Zn2+ binding site [ion binding]; other site 713604022756 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 713604022757 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 713604022758 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 713604022759 putative NAD(P) binding site [chemical binding]; other site 713604022760 catalytic Zn binding site [ion binding]; other site 713604022761 structural Zn binding site [ion binding]; other site 713604022762 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604022763 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604022764 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 713604022765 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 713604022766 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 713604022767 FeoA domain; Region: FeoA; pfam04023 713604022768 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 713604022769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604022770 Coenzyme A binding pocket [chemical binding]; other site 713604022771 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 713604022772 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 713604022773 active site 713604022774 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604022775 substrate binding site [chemical binding]; other site 713604022776 oxyanion hole (OAH) forming residues; other site 713604022777 trimer interface [polypeptide binding]; other site 713604022778 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 713604022779 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 713604022780 acyl-activating enzyme (AAE) consensus motif; other site 713604022781 putative AMP binding site [chemical binding]; other site 713604022782 putative active site [active] 713604022783 putative CoA binding site [chemical binding]; other site 713604022784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022786 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 713604022787 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604022788 active site 713604022789 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 713604022790 isochorismate synthase DhbC; Validated; Region: PRK06923 713604022791 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 713604022792 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 713604022793 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 713604022794 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 713604022795 dimer interface [polypeptide binding]; other site 713604022796 acyl-activating enzyme (AAE) consensus motif; other site 713604022797 putative active site [active] 713604022798 AMP binding site [chemical binding]; other site 713604022799 putative CoA binding site [chemical binding]; other site 713604022800 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 713604022801 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 713604022802 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 713604022803 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 713604022804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604022805 dimer interface [polypeptide binding]; other site 713604022806 conserved gate region; other site 713604022807 putative PBP binding loops; other site 713604022808 ABC-ATPase subunit interface; other site 713604022809 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 713604022810 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 713604022811 CoenzymeA binding site [chemical binding]; other site 713604022812 subunit interaction site [polypeptide binding]; other site 713604022813 PHB binding site; other site 713604022814 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 713604022815 putative active site [active] 713604022816 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 713604022817 Uncharacterized conserved protein [Function unknown]; Region: COG2128 713604022818 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604022819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604022820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604022821 DNA binding residues [nucleotide binding] 713604022822 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 713604022823 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 713604022824 NAD binding site [chemical binding]; other site 713604022825 catalytic Zn binding site [ion binding]; other site 713604022826 substrate binding site [chemical binding]; other site 713604022827 structural Zn binding site [ion binding]; other site 713604022828 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 713604022829 putative active site pocket [active] 713604022830 dimerization interface [polypeptide binding]; other site 713604022831 putative catalytic residue [active] 713604022832 FAD binding domain; Region: FAD_binding_4; pfam01565 713604022833 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 713604022834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022836 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 713604022837 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604022838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604022839 salt bridge; other site 713604022840 non-specific DNA binding site [nucleotide binding]; other site 713604022841 sequence-specific DNA binding site [nucleotide binding]; other site 713604022842 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 713604022843 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 713604022844 Walker A/P-loop; other site 713604022845 ATP binding site [chemical binding]; other site 713604022846 Q-loop/lid; other site 713604022847 ABC transporter signature motif; other site 713604022848 Walker B; other site 713604022849 D-loop; other site 713604022850 H-loop/switch region; other site 713604022851 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 713604022852 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 713604022853 DNA photolyase; Region: DNA_photolyase; pfam00875 713604022854 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 713604022855 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 713604022856 dimer interface [polypeptide binding]; other site 713604022857 active site 713604022858 citrylCoA binding site [chemical binding]; other site 713604022859 NADH binding [chemical binding]; other site 713604022860 cationic pore residues; other site 713604022861 oxalacetate/citrate binding site [chemical binding]; other site 713604022862 coenzyme A binding site [chemical binding]; other site 713604022863 catalytic triad [active] 713604022864 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604022865 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 713604022866 putative substrate binding site [chemical binding]; other site 713604022867 putative ATP binding site [chemical binding]; other site 713604022868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022870 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 713604022871 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 713604022872 active site 713604022873 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 713604022874 putative active site [active] 713604022875 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 713604022876 putative active site [active] 713604022877 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 713604022878 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 713604022879 active site 713604022880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 713604022881 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 713604022882 active site 713604022883 catalytic residues [active] 713604022884 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 713604022885 peptidase domain interface [polypeptide binding]; other site 713604022886 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604022887 active site 713604022888 catalytic triad [active] 713604022889 calcium binding site [ion binding]; other site 713604022890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022892 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 713604022893 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 713604022894 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604022895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604022896 putative substrate translocation pore; other site 713604022897 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 713604022898 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 713604022899 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 713604022900 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604022901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022903 Secretory lipase; Region: LIP; pfam03583 713604022904 UreD urease accessory protein; Region: UreD; cl00530 713604022905 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 713604022906 AAA domain; Region: AAA_18; pfam13238 713604022907 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 713604022908 urease subunit alpha; Reviewed; Region: ureC; PRK13206 713604022909 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 713604022910 subunit interactions [polypeptide binding]; other site 713604022911 active site 713604022912 flap region; other site 713604022913 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 713604022914 gamma-beta subunit interface [polypeptide binding]; other site 713604022915 alpha-beta subunit interface [polypeptide binding]; other site 713604022916 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 713604022917 alpha-gamma subunit interface [polypeptide binding]; other site 713604022918 beta-gamma subunit interface [polypeptide binding]; other site 713604022919 citrate synthase 2; Provisional; Region: PRK12350 713604022920 Citrate synthase; Region: Citrate_synt; pfam00285 713604022921 oxalacetate binding site [chemical binding]; other site 713604022922 citrylCoA binding site [chemical binding]; other site 713604022923 coenzyme A binding site [chemical binding]; other site 713604022924 catalytic triad [active] 713604022925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604022926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604022927 short chain dehydrogenase; Validated; Region: PRK05855 713604022928 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604022929 classical (c) SDRs; Region: SDR_c; cd05233 713604022930 NAD(P) binding site [chemical binding]; other site 713604022931 active site 713604022932 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604022933 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 713604022934 Walker A/P-loop; other site 713604022935 ATP binding site [chemical binding]; other site 713604022936 Q-loop/lid; other site 713604022937 ABC transporter signature motif; other site 713604022938 Walker B; other site 713604022939 D-loop; other site 713604022940 H-loop/switch region; other site 713604022941 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604022942 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 713604022943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604022944 Histidine kinase; Region: HisKA_3; pfam07730 713604022945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022946 ATP binding site [chemical binding]; other site 713604022947 G-X-G motif; other site 713604022948 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604022949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022950 active site 713604022951 phosphorylation site [posttranslational modification] 713604022952 intermolecular recognition site; other site 713604022953 dimerization interface [polypeptide binding]; other site 713604022954 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604022955 DNA binding residues [nucleotide binding] 713604022956 dimerization interface [polypeptide binding]; other site 713604022957 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604022958 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604022959 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604022960 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604022961 catalytic residue [active] 713604022962 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 713604022963 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604022964 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604022965 active site 713604022966 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 713604022967 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 713604022968 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 713604022969 FtsX-like permease family; Region: FtsX; pfam02687 713604022970 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604022971 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604022972 Walker A/P-loop; other site 713604022973 ATP binding site [chemical binding]; other site 713604022974 Q-loop/lid; other site 713604022975 ABC transporter signature motif; other site 713604022976 Walker B; other site 713604022977 D-loop; other site 713604022978 H-loop/switch region; other site 713604022979 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604022980 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604022981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604022982 active site 713604022983 phosphorylation site [posttranslational modification] 713604022984 intermolecular recognition site; other site 713604022985 dimerization interface [polypeptide binding]; other site 713604022986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604022987 DNA binding site [nucleotide binding] 713604022988 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604022989 dimerization interface [polypeptide binding]; other site 713604022990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604022991 dimer interface [polypeptide binding]; other site 713604022992 phosphorylation site [posttranslational modification] 713604022993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604022994 ATP binding site [chemical binding]; other site 713604022995 Mg2+ binding site [ion binding]; other site 713604022996 G-X-G motif; other site 713604022997 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 713604022998 Protein of unknown function (DUF419); Region: DUF419; pfam04237 713604022999 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 713604023000 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 713604023001 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 713604023002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604023003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023004 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 713604023005 heme binding pocket [chemical binding]; other site 713604023006 heme ligand [chemical binding]; other site 713604023007 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 713604023008 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 713604023009 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 713604023010 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 713604023011 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604023012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604023013 putative substrate translocation pore; other site 713604023014 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604023015 MarR family; Region: MarR; pfam01047 713604023016 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 713604023017 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 713604023018 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 713604023019 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 713604023020 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604023021 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 713604023022 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604023023 DNA-binding site [nucleotide binding]; DNA binding site 713604023024 RNA-binding motif; other site 713604023025 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 713604023026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 713604023027 motif II; other site 713604023028 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 713604023029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604023030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023031 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 713604023032 active site 713604023033 diiron metal binding site [ion binding]; other site 713604023034 AMP-binding domain protein; Validated; Region: PRK08315 713604023035 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604023036 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 713604023037 acyl-activating enzyme (AAE) consensus motif; other site 713604023038 putative AMP binding site [chemical binding]; other site 713604023039 putative active site [active] 713604023040 putative CoA binding site [chemical binding]; other site 713604023041 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604023042 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604023043 DNA binding residues [nucleotide binding] 713604023044 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604023045 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604023046 putative sugar binding sites [chemical binding]; other site 713604023047 Q-X-W motif; other site 713604023048 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 713604023049 Asp-box motif; other site 713604023050 Ycf46; Provisional; Region: ycf46; CHL00195 713604023051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023052 Walker A motif; other site 713604023053 ATP binding site [chemical binding]; other site 713604023054 Walker B motif; other site 713604023055 arginine finger; other site 713604023056 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 713604023057 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 713604023058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604023059 FeS/SAM binding site; other site 713604023060 EspG family; Region: ESX-1_EspG; pfam14011 713604023061 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 713604023062 hypothetical protein; Provisional; Region: PRK11770 713604023063 Domain of unknown function (DUF307); Region: DUF307; pfam03733 713604023064 Domain of unknown function (DUF307); Region: DUF307; pfam03733 713604023065 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 713604023066 active site 713604023067 metal binding site [ion binding]; metal-binding site 713604023068 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 713604023069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604023070 active site 713604023071 motif I; other site 713604023072 motif II; other site 713604023073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604023074 FtsI repressor; Provisional; Region: PRK10883 713604023075 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 713604023076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604023077 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 713604023078 Walker A/P-loop; other site 713604023079 ATP binding site [chemical binding]; other site 713604023080 Q-loop/lid; other site 713604023081 ABC transporter signature motif; other site 713604023082 Walker B; other site 713604023083 D-loop; other site 713604023084 H-loop/switch region; other site 713604023085 TOBE domain; Region: TOBE; pfam03459 713604023086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604023087 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 713604023088 putative PBP binding loops; other site 713604023089 ABC-ATPase subunit interface; other site 713604023090 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 713604023091 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 713604023092 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 713604023093 DNA binding residues [nucleotide binding] 713604023094 TOBE domain; Region: TOBE; cl01440 713604023095 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604023096 MarR family; Region: MarR; pfam01047 713604023097 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 713604023098 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 713604023099 FeS/SAM binding site; other site 713604023100 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 713604023101 Ubiquitin-like proteins; Region: UBQ; cl00155 713604023102 charged pocket; other site 713604023103 hydrophobic patch; other site 713604023104 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 713604023105 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 713604023106 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 713604023107 MPT binding site; other site 713604023108 trimer interface [polypeptide binding]; other site 713604023109 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 713604023110 MoaE homodimer interface [polypeptide binding]; other site 713604023111 MoaD interaction [polypeptide binding]; other site 713604023112 active site residues [active] 713604023113 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 713604023114 trimer interface [polypeptide binding]; other site 713604023115 dimer interface [polypeptide binding]; other site 713604023116 putative active site [active] 713604023117 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 713604023118 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 713604023119 Malic enzyme, N-terminal domain; Region: malic; pfam00390 713604023120 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 713604023121 NAD(P) binding pocket [chemical binding]; other site 713604023122 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 713604023123 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604023124 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604023125 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604023126 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604023127 G1 box; other site 713604023128 GTP/Mg2+ binding site [chemical binding]; other site 713604023129 G2 box; other site 713604023130 Switch I region; other site 713604023131 G3 box; other site 713604023132 Switch II region; other site 713604023133 G4 box; other site 713604023134 G5 box; other site 713604023135 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604023136 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 713604023137 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604023138 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604023139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604023140 ATP binding site [chemical binding]; other site 713604023141 Mg2+ binding site [ion binding]; other site 713604023142 G-X-G motif; other site 713604023143 NMT1/THI5 like; Region: NMT1; pfam09084 713604023144 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604023145 substrate binding pocket [chemical binding]; other site 713604023146 membrane-bound complex binding site; other site 713604023147 hinge residues; other site 713604023148 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604023149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604023150 dimer interface [polypeptide binding]; other site 713604023151 conserved gate region; other site 713604023152 putative PBP binding loops; other site 713604023153 ABC-ATPase subunit interface; other site 713604023154 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604023155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604023156 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604023157 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604023158 Walker A/P-loop; other site 713604023159 ATP binding site [chemical binding]; other site 713604023160 Q-loop/lid; other site 713604023161 ABC transporter signature motif; other site 713604023162 Walker B; other site 713604023163 D-loop; other site 713604023164 H-loop/switch region; other site 713604023165 benzoylformate decarboxylase; Reviewed; Region: PRK07092 713604023166 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 713604023167 dimer interface [polypeptide binding]; other site 713604023168 PYR/PP interface [polypeptide binding]; other site 713604023169 TPP binding site [chemical binding]; other site 713604023170 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 713604023171 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 713604023172 TPP-binding site [chemical binding]; other site 713604023173 dimer interface [polypeptide binding]; other site 713604023174 Helix-turn-helix; Region: HTH_3; pfam01381 713604023175 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 713604023176 peptidase domain interface [polypeptide binding]; other site 713604023177 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604023178 active site 713604023179 catalytic triad [active] 713604023180 calcium binding site [ion binding]; other site 713604023181 CutC family; Region: CutC; cl01218 713604023182 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604023183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604023184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604023185 ATP binding site [chemical binding]; other site 713604023186 Mg2+ binding site [ion binding]; other site 713604023187 G-X-G motif; other site 713604023188 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 713604023189 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 713604023190 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 713604023191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604023192 ATP binding site [chemical binding]; other site 713604023193 putative Mg++ binding site [ion binding]; other site 713604023194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604023195 nucleotide binding region [chemical binding]; other site 713604023196 ATP-binding site [chemical binding]; other site 713604023197 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 713604023198 Protein of unknown function DUF72; Region: DUF72; pfam01904 713604023199 O-succinylbenzoate synthase; Provisional; Region: PRK02901 713604023200 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 713604023201 active site 713604023202 PspC domain; Region: PspC; pfam04024 713604023203 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 713604023204 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 713604023205 ring oligomerisation interface [polypeptide binding]; other site 713604023206 ATP/Mg binding site [chemical binding]; other site 713604023207 stacking interactions; other site 713604023208 hinge regions; other site 713604023209 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 713604023210 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604023211 active site 713604023212 ATP binding site [chemical binding]; other site 713604023213 substrate binding site [chemical binding]; other site 713604023214 activation loop (A-loop); other site 713604023215 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 713604023216 DNA-binding site [nucleotide binding]; DNA binding site 713604023217 RNA-binding motif; other site 713604023218 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 713604023219 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 713604023220 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 713604023221 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 713604023222 dimer interface [polypeptide binding]; other site 713604023223 putative functional site; other site 713604023224 putative MPT binding site; other site 713604023225 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604023226 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604023227 putative DNA binding site [nucleotide binding]; other site 713604023228 putative Zn2+ binding site [ion binding]; other site 713604023229 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 713604023230 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 713604023231 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 713604023232 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 713604023233 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 713604023234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023235 Walker A motif; other site 713604023236 ATP binding site [chemical binding]; other site 713604023237 Walker B motif; other site 713604023238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023239 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604023240 Walker A motif; other site 713604023241 ATP binding site [chemical binding]; other site 713604023242 Walker B motif; other site 713604023243 arginine finger; other site 713604023244 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 713604023245 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 713604023246 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 713604023247 active site 713604023248 catalytic residues [active] 713604023249 metal binding site [ion binding]; metal-binding site 713604023250 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 713604023251 Domain interface; other site 713604023252 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 713604023253 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604023254 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604023255 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 713604023256 protein binding site [polypeptide binding]; other site 713604023257 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 713604023258 ThiC-associated domain; Region: ThiC-associated; pfam13667 713604023259 ThiC family; Region: ThiC; pfam01964 713604023260 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 713604023261 dimer interface [polypeptide binding]; other site 713604023262 substrate binding site [chemical binding]; other site 713604023263 ATP binding site [chemical binding]; other site 713604023264 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 713604023265 putative active site [active] 713604023266 catalytic site [active] 713604023267 putative metal binding site [ion binding]; other site 713604023268 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 713604023269 substrate binding site [chemical binding]; other site 713604023270 dimer interface [polypeptide binding]; other site 713604023271 ATP binding site [chemical binding]; other site 713604023272 MarR family; Region: MarR; pfam01047 713604023273 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604023274 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 713604023275 ThiS interaction site; other site 713604023276 putative active site [active] 713604023277 tetramer interface [polypeptide binding]; other site 713604023278 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 713604023279 thiS-thiF/thiG interaction site; other site 713604023280 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 713604023281 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 713604023282 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 713604023283 thiamine phosphate binding site [chemical binding]; other site 713604023284 active site 713604023285 pyrophosphate binding site [ion binding]; other site 713604023286 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 713604023287 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 713604023288 tetramer interface [polypeptide binding]; other site 713604023289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604023290 catalytic residue [active] 713604023291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604023292 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604023293 putative substrate translocation pore; other site 713604023294 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 713604023295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604023296 DNA-binding site [nucleotide binding]; DNA binding site 713604023297 UTRA domain; Region: UTRA; pfam07702 713604023298 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 713604023299 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 713604023300 dimer interface [polypeptide binding]; other site 713604023301 active site 713604023302 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 713604023303 dimer interface [polypeptide binding]; other site 713604023304 active site 713604023305 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 713604023306 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 713604023307 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 713604023308 active site 713604023309 catalytic triad [active] 713604023310 oxyanion hole [active] 713604023311 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 713604023312 ligand binding site [chemical binding]; other site 713604023313 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 713604023314 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 713604023315 DNA binding site [nucleotide binding] 713604023316 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604023317 NB-ARC domain; Region: NB-ARC; pfam00931 713604023318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604023319 binding surface 713604023320 TPR motif; other site 713604023321 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604023322 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 713604023323 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 713604023324 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 713604023325 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 713604023326 inhibitor-cofactor binding pocket; inhibition site 713604023327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604023328 catalytic residue [active] 713604023329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604023330 Coenzyme A binding pocket [chemical binding]; other site 713604023331 Patatin-like phospholipase; Region: Patatin; pfam01734 713604023332 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 713604023333 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 713604023334 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604023335 putative NAD(P) binding site [chemical binding]; other site 713604023336 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604023337 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604023338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 713604023339 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 713604023340 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604023341 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604023342 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 713604023343 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 713604023344 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 713604023345 active site 713604023346 dimer interface [polypeptide binding]; other site 713604023347 MarR family; Region: MarR_2; pfam12802 713604023348 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604023349 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604023350 active site 713604023351 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 713604023352 active site 713604023353 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 713604023354 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 713604023355 acyl-activating enzyme (AAE) consensus motif; other site 713604023356 AMP binding site [chemical binding]; other site 713604023357 active site 713604023358 CoA binding site [chemical binding]; other site 713604023359 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 713604023360 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 713604023361 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604023362 substrate binding site [chemical binding]; other site 713604023363 oxyanion hole (OAH) forming residues; other site 713604023364 trimer interface [polypeptide binding]; other site 713604023365 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 713604023366 substrate binding site [chemical binding]; other site 713604023367 trimer interface [polypeptide binding]; other site 713604023368 oxyanion hole (OAH) forming residues; other site 713604023369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 713604023370 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604023371 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604023372 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604023373 PA14 domain; Region: PA14; cl08459 713604023374 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604023375 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 713604023376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604023377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023378 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604023379 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604023380 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604023381 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604023382 RibD C-terminal domain; Region: RibD_C; cl17279 713604023383 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604023384 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604023385 MarR family; Region: MarR_2; pfam12802 713604023386 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 713604023387 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 713604023388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604023389 Walker A/P-loop; other site 713604023390 ATP binding site [chemical binding]; other site 713604023391 Q-loop/lid; other site 713604023392 ABC transporter signature motif; other site 713604023393 Walker B; other site 713604023394 D-loop; other site 713604023395 H-loop/switch region; other site 713604023396 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 713604023397 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 713604023398 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 713604023399 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604023400 Zn binding site [ion binding]; other site 713604023401 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 713604023402 NHL repeat; Region: NHL; pfam01436 713604023403 NHL repeat; Region: NHL; pfam01436 713604023404 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 713604023405 Gas vesicle protein; Region: Gas_vesicle; cl02954 713604023406 Gas vesicle protein K; Region: GvpK; pfam05121 713604023407 Gas vesicle protein; Region: Gas_vesicle; cl02954 713604023408 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 713604023409 Gas vesicle protein; Region: Gas_vesicle; pfam00741 713604023410 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 713604023411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604023412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604023413 active site 713604023414 phosphorylation site [posttranslational modification] 713604023415 intermolecular recognition site; other site 713604023416 dimerization interface [polypeptide binding]; other site 713604023417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604023418 DNA binding site [nucleotide binding] 713604023419 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 713604023420 dimerization interface [polypeptide binding]; other site 713604023421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604023422 dimer interface [polypeptide binding]; other site 713604023423 phosphorylation site [posttranslational modification] 713604023424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604023425 ATP binding site [chemical binding]; other site 713604023426 Mg2+ binding site [ion binding]; other site 713604023427 G-X-G motif; other site 713604023428 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 713604023429 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 713604023430 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 713604023431 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604023432 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 713604023433 putative NAD(P) binding site [chemical binding]; other site 713604023434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023435 Transcriptional regulator [Transcription]; Region: IclR; COG1414 713604023436 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 713604023437 Bacterial transcriptional regulator; Region: IclR; pfam01614 713604023438 L-lactate permease; Region: Lactate_perm; cl00701 713604023439 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 713604023440 HD domain; Region: HD_3; pfam13023 713604023441 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604023442 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604023443 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604023444 YCII-related domain; Region: YCII; cl00999 713604023445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 713604023446 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 713604023447 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604023448 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 713604023449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604023450 HAMP domain; Region: HAMP; pfam00672 713604023451 dimerization interface [polypeptide binding]; other site 713604023452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604023453 dimer interface [polypeptide binding]; other site 713604023454 phosphorylation site [posttranslational modification] 713604023455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604023456 ATP binding site [chemical binding]; other site 713604023457 Mg2+ binding site [ion binding]; other site 713604023458 G-X-G motif; other site 713604023459 Predicted membrane protein [Function unknown]; Region: COG3463 713604023460 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 713604023461 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 713604023462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 713604023463 binding surface 713604023464 TPR motif; other site 713604023465 Tetratricopeptide repeat; Region: TPR_12; pfam13424 713604023466 CHAT domain; Region: CHAT; pfam12770 713604023467 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604023468 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604023469 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 713604023470 active site 713604023471 catalytic residues [active] 713604023472 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 713604023473 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 713604023474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604023475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604023476 DNA binding residues [nucleotide binding] 713604023477 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604023478 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 713604023479 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 713604023480 sugar binding site [chemical binding]; other site 713604023481 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 713604023482 Ca binding site [ion binding]; other site 713604023483 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 713604023484 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 713604023485 Ca binding site [ion binding]; other site 713604023486 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 713604023487 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 713604023488 active site 713604023489 catalytic triad [active] 713604023490 calcium binding site [ion binding]; other site 713604023491 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 713604023492 Erythromycin esterase; Region: Erythro_esteras; pfam05139 713604023493 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 713604023494 DNA binding residues [nucleotide binding] 713604023495 mercuric resistence transcriptional repressor protein MerD; Region: MerD; TIGR02054 713604023496 putative dimer interface [polypeptide binding]; other site 713604023497 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 713604023498 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604023499 DNA binding residues [nucleotide binding] 713604023500 putative dimer interface [polypeptide binding]; other site 713604023501 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604023502 Uncharacterized conserved protein [Function unknown]; Region: COG2966 713604023503 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 713604023504 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 713604023505 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 713604023506 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 713604023507 active site 713604023508 homotetramer interface [polypeptide binding]; other site 713604023509 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 713604023510 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 713604023511 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 713604023512 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 713604023513 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604023514 dimerization interface [polypeptide binding]; other site 713604023515 putative DNA binding site [nucleotide binding]; other site 713604023516 putative Zn2+ binding site [ion binding]; other site 713604023517 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604023518 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604023519 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 713604023520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604023521 DNA repair protein RadA; Provisional; Region: PRK11823 713604023522 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604023523 Walker A motif; other site 713604023524 ATP binding site [chemical binding]; other site 713604023525 Walker B motif; other site 713604023526 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 713604023527 Protein of unknown function (DUF461); Region: DUF461; cl01071 713604023528 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 713604023529 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604023530 active site 713604023531 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 713604023532 homotrimer interaction site [polypeptide binding]; other site 713604023533 zinc binding site [ion binding]; other site 713604023534 CDP-binding sites; other site 713604023535 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604023536 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604023537 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 713604023538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604023539 motif II; other site 713604023540 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 713604023541 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604023542 active site 713604023543 HIGH motif; other site 713604023544 nucleotide binding site [chemical binding]; other site 713604023545 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 713604023546 KMSKS motif; other site 713604023547 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 713604023548 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 713604023549 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 713604023550 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 713604023551 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 713604023552 phosphoglycerate mutase; Provisional; Region: PTZ00122 713604023553 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 713604023554 catalytic core [active] 713604023555 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 713604023556 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 713604023557 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 713604023558 intersubunit interface [polypeptide binding]; other site 713604023559 active site 713604023560 Zn2+ binding site [ion binding]; other site 713604023561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 713604023562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 713604023563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 713604023564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 713604023565 dimer interface [polypeptide binding]; other site 713604023566 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 713604023567 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 713604023568 putative PBP binding regions; other site 713604023569 ABC-ATPase subunit interface; other site 713604023570 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 713604023571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604023572 Walker A/P-loop; other site 713604023573 ATP binding site [chemical binding]; other site 713604023574 Q-loop/lid; other site 713604023575 ABC transporter signature motif; other site 713604023576 Walker B; other site 713604023577 D-loop; other site 713604023578 H-loop/switch region; other site 713604023579 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 713604023580 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 713604023581 intersubunit interface [polypeptide binding]; other site 713604023582 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604023583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604023584 DNA binding site [nucleotide binding] 713604023585 domain linker motif; other site 713604023586 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 713604023587 putative dimerization interface [polypeptide binding]; other site 713604023588 putative ligand binding site [chemical binding]; other site 713604023589 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 713604023590 active site clefts [active] 713604023591 zinc binding site [ion binding]; other site 713604023592 dimer interface [polypeptide binding]; other site 713604023593 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604023594 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604023595 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 713604023596 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 713604023597 minor groove reading motif; other site 713604023598 helix-hairpin-helix signature motif; other site 713604023599 active site 713604023600 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 713604023601 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 713604023602 amidase catalytic site [active] 713604023603 Zn binding residues [ion binding]; other site 713604023604 substrate binding site [chemical binding]; other site 713604023605 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604023606 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 713604023607 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604023608 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 713604023609 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 713604023610 Peptidase family M1; Region: Peptidase_M1; pfam01433 713604023611 Zn binding site [ion binding]; other site 713604023612 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 713604023613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023614 Walker A motif; other site 713604023615 ATP binding site [chemical binding]; other site 713604023616 Walker B motif; other site 713604023617 arginine finger; other site 713604023618 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 713604023619 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 713604023620 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 713604023621 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604023622 Walker A motif; other site 713604023623 ATP binding site [chemical binding]; other site 713604023624 Walker B motif; other site 713604023625 hypothetical protein; Validated; Region: PRK09169 713604023626 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 713604023627 putative catalytic site [active] 713604023628 putative metal binding site [ion binding]; other site 713604023629 putative phosphate binding site [ion binding]; other site 713604023630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604023631 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 713604023632 Walker A/P-loop; other site 713604023633 ATP binding site [chemical binding]; other site 713604023634 Q-loop/lid; other site 713604023635 ABC transporter signature motif; other site 713604023636 Walker B; other site 713604023637 D-loop; other site 713604023638 H-loop/switch region; other site 713604023639 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 713604023640 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 713604023641 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 713604023642 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 713604023643 Predicted ATPase [General function prediction only]; Region: COG3903 713604023644 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 713604023645 Zn binding site [ion binding]; other site 713604023646 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 713604023647 putative substrate binding pocket [chemical binding]; other site 713604023648 AC domain interface; other site 713604023649 catalytic triad [active] 713604023650 AB domain interface; other site 713604023651 interchain disulfide; other site 713604023652 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 713604023653 nucleotide binding site [chemical binding]; other site 713604023654 putative NEF/HSP70 interaction site [polypeptide binding]; other site 713604023655 SBD interface [polypeptide binding]; other site 713604023656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604023657 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604023658 non-specific DNA binding site [nucleotide binding]; other site 713604023659 salt bridge; other site 713604023660 sequence-specific DNA binding site [nucleotide binding]; other site 713604023661 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 713604023662 Clp amino terminal domain; Region: Clp_N; pfam02861 713604023663 Clp amino terminal domain; Region: Clp_N; pfam02861 713604023664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023665 Walker A motif; other site 713604023666 ATP binding site [chemical binding]; other site 713604023667 Walker B motif; other site 713604023668 arginine finger; other site 713604023669 UvrB/uvrC motif; Region: UVR; pfam02151 713604023670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023671 Walker A motif; other site 713604023672 ATP binding site [chemical binding]; other site 713604023673 Walker B motif; other site 713604023674 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 713604023675 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 713604023676 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 713604023677 TIGR03086 family protein; Region: TIGR03086 713604023678 Helix-turn-helix domain; Region: HTH_18; pfam12833 713604023679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 713604023680 Lsr2; Region: Lsr2; pfam11774 713604023681 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 713604023682 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 713604023683 dimer interface [polypeptide binding]; other site 713604023684 putative anticodon binding site; other site 713604023685 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 713604023686 motif 1; other site 713604023687 dimer interface [polypeptide binding]; other site 713604023688 active site 713604023689 motif 2; other site 713604023690 motif 3; other site 713604023691 Methyltransferase domain; Region: Methyltransf_11; pfam08241 713604023692 pantothenate kinase; Reviewed; Region: PRK13318 713604023693 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 713604023694 tetramerization interface [polypeptide binding]; other site 713604023695 active site 713604023696 Pantoate-beta-alanine ligase; Region: PanC; cd00560 713604023697 pantoate--beta-alanine ligase; Region: panC; TIGR00018 713604023698 active site 713604023699 ATP-binding site [chemical binding]; other site 713604023700 pantoate-binding site; other site 713604023701 HXXH motif; other site 713604023702 Rossmann-like domain; Region: Rossmann-like; pfam10727 713604023703 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 713604023704 Protease prsW family; Region: PrsW-protease; pfam13367 713604023705 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 713604023706 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604023707 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604023708 DNA binding residues [nucleotide binding] 713604023709 dimer interface [polypeptide binding]; other site 713604023710 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 713604023711 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 713604023712 catalytic center binding site [active] 713604023713 ATP binding site [chemical binding]; other site 713604023714 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 713604023715 homooctamer interface [polypeptide binding]; other site 713604023716 active site 713604023717 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 713604023718 dihydropteroate synthase; Region: DHPS; TIGR01496 713604023719 substrate binding pocket [chemical binding]; other site 713604023720 dimer interface [polypeptide binding]; other site 713604023721 inhibitor binding site; inhibition site 713604023722 GTP cyclohydrolase I; Provisional; Region: PLN03044 713604023723 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 713604023724 homodecamer interface [polypeptide binding]; other site 713604023725 active site 713604023726 putative catalytic site residues [active] 713604023727 zinc binding site [ion binding]; other site 713604023728 GTP-CH-I/GFRP interaction surface; other site 713604023729 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 713604023730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023731 Walker A motif; other site 713604023732 ATP binding site [chemical binding]; other site 713604023733 Walker B motif; other site 713604023734 arginine finger; other site 713604023735 Peptidase family M41; Region: Peptidase_M41; pfam01434 713604023736 EspG family; Region: ESX-1_EspG; pfam14011 713604023737 EspG family; Region: ESX-1_EspG; pfam14011 713604023738 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604023739 active site 713604023740 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 713604023741 Ligand Binding Site [chemical binding]; other site 713604023742 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 713604023743 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 713604023744 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 713604023745 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 713604023746 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 713604023747 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 713604023748 dimer interface [polypeptide binding]; other site 713604023749 substrate binding site [chemical binding]; other site 713604023750 metal binding sites [ion binding]; metal-binding site 713604023751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604023752 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604023753 putative substrate translocation pore; other site 713604023754 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 713604023755 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 713604023756 dimer interface [polypeptide binding]; other site 713604023757 active site 713604023758 glycine-pyridoxal phosphate binding site [chemical binding]; other site 713604023759 folate binding site [chemical binding]; other site 713604023760 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 713604023761 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 713604023762 23S rRNA interface [nucleotide binding]; other site 713604023763 L7/L12 interface [polypeptide binding]; other site 713604023764 putative thiostrepton binding site; other site 713604023765 L25 interface [polypeptide binding]; other site 713604023766 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 713604023767 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 713604023768 trimer interface [polypeptide binding]; other site 713604023769 putative metal binding site [ion binding]; other site 713604023770 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 713604023771 putative active site [active] 713604023772 Zn binding site [ion binding]; other site 713604023773 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 713604023774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023775 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 713604023776 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 713604023777 EthD domain; Region: EthD; cl17553 713604023778 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604023779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604023780 non-specific DNA binding site [nucleotide binding]; other site 713604023781 salt bridge; other site 713604023782 sequence-specific DNA binding site [nucleotide binding]; other site 713604023783 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 713604023784 nudix motif; other site 713604023785 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604023786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604023787 non-specific DNA binding site [nucleotide binding]; other site 713604023788 salt bridge; other site 713604023789 sequence-specific DNA binding site [nucleotide binding]; other site 713604023790 Phosphotransferase enzyme family; Region: APH; pfam01636 713604023791 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 713604023792 substrate binding site [chemical binding]; other site 713604023793 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604023794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604023795 DNA-binding site [nucleotide binding]; DNA binding site 713604023796 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604023797 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 713604023798 Helix-turn-helix domain; Region: HTH_17; pfam12728 713604023799 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 713604023800 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 713604023801 active site 713604023802 DNA binding site [nucleotide binding] 713604023803 Int/Topo IB signature motif; other site 713604023804 DNA polymerase III subunit delta'; Validated; Region: PRK07940 713604023805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604023806 Walker A motif; other site 713604023807 ATP binding site [chemical binding]; other site 713604023808 Walker B motif; other site 713604023809 arginine finger; other site 713604023810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604023811 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604023812 putative substrate translocation pore; other site 713604023813 thymidylate kinase; Validated; Region: tmk; PRK00698 713604023814 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 713604023815 TMP-binding site; other site 713604023816 ATP-binding site [chemical binding]; other site 713604023817 EspG family; Region: ESX-1_EspG; pfam14011 713604023818 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 713604023819 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 713604023820 active site 713604023821 interdomain interaction site; other site 713604023822 putative metal-binding site [ion binding]; other site 713604023823 nucleotide binding site [chemical binding]; other site 713604023824 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 713604023825 domain I; other site 713604023826 phosphate binding site [ion binding]; other site 713604023827 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 713604023828 domain II; other site 713604023829 domain III; other site 713604023830 nucleotide binding site [chemical binding]; other site 713604023831 DNA binding groove [nucleotide binding] 713604023832 catalytic site [active] 713604023833 domain IV; other site 713604023834 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 713604023835 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 713604023836 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 713604023837 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604023838 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 713604023839 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 713604023840 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 713604023841 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604023842 ATP binding site [chemical binding]; other site 713604023843 putative Mg++ binding site [ion binding]; other site 713604023844 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604023845 nucleotide binding region [chemical binding]; other site 713604023846 ATP-binding site [chemical binding]; other site 713604023847 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 713604023848 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 713604023849 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 713604023850 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 713604023851 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 713604023852 Type II/IV secretion system protein; Region: T2SE; pfam00437 713604023853 Walker A motif; other site 713604023854 ATP binding site [chemical binding]; other site 713604023855 Walker B motif; other site 713604023856 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 713604023857 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 713604023858 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 713604023859 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 713604023860 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 713604023861 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 713604023862 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 713604023863 Beta-lactamase; Region: Beta-lactamase; cl17358 713604023864 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604023865 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 713604023866 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 713604023867 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 713604023868 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 713604023869 putative active site [active] 713604023870 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 713604023871 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 713604023872 putative active site [active] 713604023873 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 713604023874 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 713604023875 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604023876 active site 713604023877 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604023878 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604023879 acetyl-CoA synthetase; Provisional; Region: PRK00174 713604023880 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 713604023881 active site 713604023882 CoA binding site [chemical binding]; other site 713604023883 acyl-activating enzyme (AAE) consensus motif; other site 713604023884 AMP binding site [chemical binding]; other site 713604023885 acetate binding site [chemical binding]; other site 713604023886 Cupin domain; Region: Cupin_2; pfam07883 713604023887 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 713604023888 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 713604023889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604023890 putative substrate translocation pore; other site 713604023891 POT family; Region: PTR2; cl17359 713604023892 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 713604023893 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 713604023894 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604023895 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604023896 hypothetical protein; Validated; Region: PRK05868 713604023897 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604023898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604023899 DNA-binding site [nucleotide binding]; DNA binding site 713604023900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604023901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604023902 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 713604023903 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 713604023904 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 713604023905 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 713604023906 putative active site [active] 713604023907 putative CoA binding site [chemical binding]; other site 713604023908 nudix motif; other site 713604023909 metal binding site [ion binding]; metal-binding site 713604023910 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 713604023911 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 713604023912 catalytic residues [active] 713604023913 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 713604023914 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 713604023915 minor groove reading motif; other site 713604023916 helix-hairpin-helix signature motif; other site 713604023917 substrate binding pocket [chemical binding]; other site 713604023918 active site 713604023919 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 713604023920 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 713604023921 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 713604023922 ligand binding site [chemical binding]; other site 713604023923 flexible hinge region; other site 713604023924 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 713604023925 putative switch regulator; other site 713604023926 non-specific DNA interactions [nucleotide binding]; other site 713604023927 DNA binding site [nucleotide binding] 713604023928 sequence specific DNA binding site [nucleotide binding]; other site 713604023929 putative cAMP binding site [chemical binding]; other site 713604023930 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 713604023931 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 713604023932 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 713604023933 putative DNA binding surface [nucleotide binding]; other site 713604023934 dimer interface [polypeptide binding]; other site 713604023935 beta-clamp/clamp loader binding surface; other site 713604023936 beta-clamp/translesion DNA polymerase binding surface; other site 713604023937 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604023938 AsnC family; Region: AsnC_trans_reg; pfam01037 713604023939 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604023940 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604023941 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 713604023942 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 713604023943 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604023944 substrate binding pocket [chemical binding]; other site 713604023945 catalytic triad [active] 713604023946 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 713604023947 catalytic residues [active] 713604023948 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 713604023949 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 713604023950 nudix motif; other site 713604023951 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 713604023952 homotrimer interaction site [polypeptide binding]; other site 713604023953 putative active site [active] 713604023954 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 713604023955 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 713604023956 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 713604023957 DTAP/Switch II; other site 713604023958 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 713604023959 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 713604023960 P loop; other site 713604023961 Nucleotide binding site [chemical binding]; other site 713604023962 DTAP/Switch II; other site 713604023963 Switch I; other site 713604023964 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 713604023965 Transcription factor WhiB; Region: Whib; pfam02467 713604023966 Transglycosylase; Region: Transgly; pfam00912 713604023967 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 713604023968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604023969 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604023970 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604023971 active site 713604023972 ATP binding site [chemical binding]; other site 713604023973 substrate binding site [chemical binding]; other site 713604023974 activation loop (A-loop); other site 713604023975 phosphodiesterase YaeI; Provisional; Region: PRK11340 713604023976 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 713604023977 putative active site [active] 713604023978 putative metal binding site [ion binding]; other site 713604023979 Methyltransferase domain; Region: Methyltransf_23; pfam13489 713604023980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604023981 S-adenosylmethionine binding site [chemical binding]; other site 713604023982 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 713604023983 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604023984 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 713604023985 active site 1 [active] 713604023986 dimer interface [polypeptide binding]; other site 713604023987 hexamer interface [polypeptide binding]; other site 713604023988 active site 2 [active] 713604023989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 713604023990 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 713604023991 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 713604023992 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 713604023993 TIGR03085 family protein; Region: TIGR03085 713604023994 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 713604023995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604023996 catalytic residue [active] 713604023997 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 713604023998 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 713604023999 dimerization interface [polypeptide binding]; other site 713604024000 DPS ferroxidase diiron center [ion binding]; other site 713604024001 ion pore; other site 713604024002 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 713604024003 Predicted flavoprotein [General function prediction only]; Region: COG0431 713604024004 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604024005 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 713604024006 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 713604024007 substrate binding pocket [chemical binding]; other site 713604024008 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 713604024009 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 713604024010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024012 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604024013 putative substrate translocation pore; other site 713604024014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024016 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604024017 putative substrate translocation pore; other site 713604024018 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 713604024019 hypothetical protein; Reviewed; Region: PRK09588 713604024020 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 713604024021 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 713604024022 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 713604024023 aspartate kinase; Reviewed; Region: PRK06635 713604024024 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 713604024025 putative nucleotide binding site [chemical binding]; other site 713604024026 putative catalytic residues [active] 713604024027 putative Mg ion binding site [ion binding]; other site 713604024028 putative aspartate binding site [chemical binding]; other site 713604024029 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 713604024030 putative allosteric regulatory site; other site 713604024031 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 713604024032 putative allosteric regulatory residue; other site 713604024033 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 713604024034 putative FMN binding site [chemical binding]; other site 713604024035 2-isopropylmalate synthase; Validated; Region: PRK03739 713604024036 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 713604024037 active site 713604024038 catalytic residues [active] 713604024039 metal binding site [ion binding]; metal-binding site 713604024040 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 713604024041 Predicted transcriptional regulator [Transcription]; Region: COG2378 713604024042 HTH domain; Region: HTH_11; pfam08279 713604024043 WYL domain; Region: WYL; pfam13280 713604024044 short chain dehydrogenase; Provisional; Region: PRK08303 713604024045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604024046 NAD(P) binding site [chemical binding]; other site 713604024047 active site 713604024048 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604024049 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 713604024050 putative catalytic residues [active] 713604024051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604024052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024053 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 713604024054 Transcriptional regulator [Transcription]; Region: LysR; COG0583 713604024055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 713604024056 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 713604024057 putative dimerization interface [polypeptide binding]; other site 713604024058 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 713604024059 EamA-like transporter family; Region: EamA; pfam00892 713604024060 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604024061 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 713604024062 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 713604024063 SnoaL-like domain; Region: SnoaL_3; pfam13474 713604024064 YCII-related domain; Region: YCII; cl00999 713604024065 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604024066 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604024067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604024068 DNA binding residues [nucleotide binding] 713604024069 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 713604024070 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604024071 Walker A/P-loop; other site 713604024072 ATP binding site [chemical binding]; other site 713604024073 Q-loop/lid; other site 713604024074 ABC transporter signature motif; other site 713604024075 Walker B; other site 713604024076 D-loop; other site 713604024077 H-loop/switch region; other site 713604024078 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 713604024079 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 713604024080 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 713604024081 Walker A/P-loop; other site 713604024082 ATP binding site [chemical binding]; other site 713604024083 Q-loop/lid; other site 713604024084 ABC transporter signature motif; other site 713604024085 Walker B; other site 713604024086 D-loop; other site 713604024087 H-loop/switch region; other site 713604024088 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 713604024089 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 713604024090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024091 dimer interface [polypeptide binding]; other site 713604024092 conserved gate region; other site 713604024093 putative PBP binding loops; other site 713604024094 ABC-ATPase subunit interface; other site 713604024095 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 713604024096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024097 dimer interface [polypeptide binding]; other site 713604024098 conserved gate region; other site 713604024099 putative PBP binding loops; other site 713604024100 ABC-ATPase subunit interface; other site 713604024101 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 713604024102 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 713604024103 peptide binding site [polypeptide binding]; other site 713604024104 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 713604024105 Ligand binding site; other site 713604024106 Putative Catalytic site; other site 713604024107 DXD motif; other site 713604024108 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 713604024109 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 713604024110 active site 713604024111 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604024112 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 713604024113 recombination protein RecR; Reviewed; Region: recR; PRK00076 713604024114 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 713604024115 RecR protein; Region: RecR; pfam02132 713604024116 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 713604024117 putative active site [active] 713604024118 putative metal-binding site [ion binding]; other site 713604024119 tetramer interface [polypeptide binding]; other site 713604024120 hypothetical protein; Validated; Region: PRK00153 713604024121 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 713604024122 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 713604024123 active site 713604024124 metal binding site [ion binding]; metal-binding site 713604024125 Predicted transcriptional regulators [Transcription]; Region: COG1733 713604024126 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 713604024127 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604024128 HTH-like domain; Region: HTH_21; pfam13276 713604024129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 713604024130 Integrase core domain; Region: rve; pfam00665 713604024131 Integrase core domain; Region: rve_3; pfam13683 713604024132 Transposase; Region: HTH_Tnp_1; pfam01527 713604024133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 713604024134 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 713604024135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604024136 Walker A motif; other site 713604024137 ATP binding site [chemical binding]; other site 713604024138 Walker B motif; other site 713604024139 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 713604024140 Short repeats of unknown function; Region: ALF; pfam03752 713604024141 Short repeats of unknown function; Region: ALF; pfam03752 713604024142 Short repeats of unknown function; Region: ALF; pfam03752 713604024143 Short repeats of unknown function; Region: ALF; pfam03752 713604024144 Short repeats of unknown function; Region: ALF; pfam03752 713604024145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604024146 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 713604024147 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 713604024148 G1 box; other site 713604024149 GTP/Mg2+ binding site [chemical binding]; other site 713604024150 G2 box; other site 713604024151 Switch I region; other site 713604024152 G3 box; other site 713604024153 Switch II region; other site 713604024154 G4 box; other site 713604024155 G5 box; other site 713604024156 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604024157 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 713604024158 Nitrate and nitrite sensing; Region: NIT; pfam08376 713604024159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604024160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604024161 ATP binding site [chemical binding]; other site 713604024162 Mg2+ binding site [ion binding]; other site 713604024163 G-X-G motif; other site 713604024164 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 713604024165 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 713604024166 Walker A/P-loop; other site 713604024167 ATP binding site [chemical binding]; other site 713604024168 Q-loop/lid; other site 713604024169 ABC transporter signature motif; other site 713604024170 Walker B; other site 713604024171 D-loop; other site 713604024172 H-loop/switch region; other site 713604024173 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 713604024174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024175 dimer interface [polypeptide binding]; other site 713604024176 conserved gate region; other site 713604024177 putative PBP binding loops; other site 713604024178 ABC-ATPase subunit interface; other site 713604024179 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 713604024180 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 713604024181 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 713604024182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 713604024183 HAMP domain; Region: HAMP; pfam00672 713604024184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 713604024185 dimer interface [polypeptide binding]; other site 713604024186 phosphorylation site [posttranslational modification] 713604024187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604024188 ATP binding site [chemical binding]; other site 713604024189 Mg2+ binding site [ion binding]; other site 713604024190 G-X-G motif; other site 713604024191 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 713604024192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604024193 active site 713604024194 phosphorylation site [posttranslational modification] 713604024195 intermolecular recognition site; other site 713604024196 dimerization interface [polypeptide binding]; other site 713604024197 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604024198 DNA binding site [nucleotide binding] 713604024199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604024200 Histidine kinase; Region: HisKA_3; pfam07730 713604024201 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604024202 Mg2+ binding site [ion binding]; other site 713604024203 G-X-G motif; other site 713604024204 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604024205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604024206 active site 713604024207 phosphorylation site [posttranslational modification] 713604024208 intermolecular recognition site; other site 713604024209 dimerization interface [polypeptide binding]; other site 713604024210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604024211 DNA binding residues [nucleotide binding] 713604024212 dimerization interface [polypeptide binding]; other site 713604024213 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604024214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604024215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024216 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 713604024217 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604024218 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604024219 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604024220 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 713604024221 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 713604024222 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 713604024223 LGFP repeat; Region: LGFP; pfam08310 713604024224 LGFP repeat; Region: LGFP; pfam08310 713604024225 LGFP repeat; Region: LGFP; pfam08310 713604024226 LGFP repeat; Region: LGFP; pfam08310 713604024227 LGFP repeat; Region: LGFP; pfam08310 713604024228 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 713604024229 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 713604024230 Catalytic domain of Protein Kinases; Region: PKc; cd00180 713604024231 active site 713604024232 ATP binding site [chemical binding]; other site 713604024233 substrate binding site [chemical binding]; other site 713604024234 activation loop (A-loop); other site 713604024235 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 713604024236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604024237 S-adenosylmethionine binding site [chemical binding]; other site 713604024238 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 713604024239 Protein phosphatase 2C; Region: PP2C; pfam00481 713604024240 active site 713604024241 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 713604024242 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 713604024243 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 713604024244 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 713604024245 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 713604024246 generic binding surface I; other site 713604024247 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 713604024248 putative active site [active] 713604024249 putative catalytic site [active] 713604024250 putative Mg binding site IVb [ion binding]; other site 713604024251 putative phosphate binding site [ion binding]; other site 713604024252 putative DNA binding site [nucleotide binding]; other site 713604024253 putative Mg binding site IVa [ion binding]; other site 713604024254 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 713604024255 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 713604024256 putative active site [active] 713604024257 putative metal binding site [ion binding]; other site 713604024258 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 713604024259 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 713604024260 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 713604024261 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 713604024262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604024263 NAD(P) binding site [chemical binding]; other site 713604024264 active site 713604024265 CsbD-like; Region: CsbD; pfam05532 713604024266 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 713604024267 nucleoside/Zn binding site; other site 713604024268 dimer interface [polypeptide binding]; other site 713604024269 catalytic motif [active] 713604024270 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 713604024271 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 713604024272 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 713604024273 metal binding site [ion binding]; metal-binding site 713604024274 dimer interface [polypeptide binding]; other site 713604024275 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 713604024276 Phosphoesterase family; Region: Phosphoesterase; pfam04185 713604024277 Domain of unknown function (DUF756); Region: DUF756; pfam05506 713604024278 Domain of unknown function (DUF756); Region: DUF756; pfam05506 713604024279 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 713604024280 active site 713604024281 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604024282 Domain of unknown function (DUF336); Region: DUF336; cl01249 713604024283 RibD C-terminal domain; Region: RibD_C; cl17279 713604024284 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 713604024285 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 713604024286 active site 713604024287 dimer interface [polypeptide binding]; other site 713604024288 motif 1; other site 713604024289 motif 2; other site 713604024290 motif 3; other site 713604024291 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 713604024292 anticodon binding site; other site 713604024293 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 713604024294 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604024295 DNA binding residues [nucleotide binding] 713604024296 dimer interface [polypeptide binding]; other site 713604024297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 713604024298 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 713604024299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024300 dimer interface [polypeptide binding]; other site 713604024301 conserved gate region; other site 713604024302 putative PBP binding loops; other site 713604024303 ABC-ATPase subunit interface; other site 713604024304 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 713604024305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604024306 Walker A/P-loop; other site 713604024307 ATP binding site [chemical binding]; other site 713604024308 Q-loop/lid; other site 713604024309 ABC transporter signature motif; other site 713604024310 Walker B; other site 713604024311 D-loop; other site 713604024312 H-loop/switch region; other site 713604024313 TOBE domain; Region: TOBE_2; pfam08402 713604024314 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 713604024315 hypothetical protein; Provisional; Region: PRK11622 713604024316 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 713604024317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604024318 DNA-binding site [nucleotide binding]; DNA binding site 713604024319 FCD domain; Region: FCD; pfam07729 713604024320 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 713604024321 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 713604024322 inhibitor site; inhibition site 713604024323 active site 713604024324 dimer interface [polypeptide binding]; other site 713604024325 catalytic residue [active] 713604024326 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 713604024327 putative di-iron ligands [ion binding]; other site 713604024328 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 713604024329 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 713604024330 active site 713604024331 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 713604024332 substrate binding site [chemical binding]; other site 713604024333 catalytic residues [active] 713604024334 dimer interface [polypeptide binding]; other site 713604024335 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 713604024336 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 713604024337 AsnC family; Region: AsnC_trans_reg; pfam01037 713604024338 Part of AAA domain; Region: AAA_19; pfam13245 713604024339 Family description; Region: UvrD_C_2; pfam13538 713604024340 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 713604024341 putative active site [active] 713604024342 putative metal binding site [ion binding]; other site 713604024343 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 713604024344 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 713604024345 intermolecular salt bridges; other site 713604024346 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604024347 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604024348 active site 713604024349 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 713604024350 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604024351 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604024352 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 713604024353 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 713604024354 FMN binding site [chemical binding]; other site 713604024355 active site 713604024356 catalytic residues [active] 713604024357 substrate binding site [chemical binding]; other site 713604024358 alpha-galactosidase; Region: PLN02808; cl17638 713604024359 alpha-galactosidase; Region: PLN02808; cl17638 713604024360 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 713604024361 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 713604024362 putative sugar binding sites [chemical binding]; other site 713604024363 Q-X-W motif; other site 713604024364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604024365 DNA-binding site [nucleotide binding]; DNA binding site 713604024366 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 713604024367 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 713604024368 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 713604024369 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604024370 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604024371 substrate binding site [chemical binding]; other site 713604024372 ATP binding site [chemical binding]; other site 713604024373 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 713604024374 Isochorismatase family; Region: Isochorismatase; pfam00857 713604024375 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 713604024376 catalytic triad [active] 713604024377 conserved cis-peptide bond; other site 713604024378 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 713604024379 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604024380 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 713604024381 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 713604024382 active site 713604024383 metal binding site [ion binding]; metal-binding site 713604024384 nudix motif; other site 713604024385 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604024386 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604024387 metal binding site [ion binding]; metal-binding site 713604024388 active site 713604024389 I-site; other site 713604024390 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 713604024391 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 713604024392 PhoU domain; Region: PhoU; pfam01895 713604024393 PhoU domain; Region: PhoU; pfam01895 713604024394 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 713604024395 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 713604024396 Walker A/P-loop; other site 713604024397 ATP binding site [chemical binding]; other site 713604024398 Q-loop/lid; other site 713604024399 ABC transporter signature motif; other site 713604024400 Walker B; other site 713604024401 D-loop; other site 713604024402 H-loop/switch region; other site 713604024403 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 713604024404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024405 dimer interface [polypeptide binding]; other site 713604024406 conserved gate region; other site 713604024407 putative PBP binding loops; other site 713604024408 ABC-ATPase subunit interface; other site 713604024409 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 713604024410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024411 dimer interface [polypeptide binding]; other site 713604024412 conserved gate region; other site 713604024413 putative PBP binding loops; other site 713604024414 ABC-ATPase subunit interface; other site 713604024415 PBP superfamily domain; Region: PBP_like_2; cl17296 713604024416 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 713604024417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604024418 Coenzyme A binding pocket [chemical binding]; other site 713604024419 DNA-binding response regulator CreB; Provisional; Region: PRK11083 713604024420 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 713604024421 DNA binding site [nucleotide binding] 713604024422 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 713604024423 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 713604024424 catalytic residues [active] 713604024425 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 713604024426 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 713604024427 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 713604024428 active site residue [active] 713604024429 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 713604024430 active site residue [active] 713604024431 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 713604024432 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 713604024433 heme-binding site [chemical binding]; other site 713604024434 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 713604024435 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 713604024436 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 713604024437 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 713604024438 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 713604024439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604024440 catalytic residue [active] 713604024441 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 713604024442 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 713604024443 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 713604024444 L-asparaginase II; Region: Asparaginase_II; pfam06089 713604024445 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 713604024446 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 713604024447 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 713604024448 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 713604024449 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 713604024450 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 713604024451 Walker A/P-loop; other site 713604024452 ATP binding site [chemical binding]; other site 713604024453 Q-loop/lid; other site 713604024454 ABC transporter signature motif; other site 713604024455 Walker B; other site 713604024456 D-loop; other site 713604024457 H-loop/switch region; other site 713604024458 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 713604024459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604024460 Walker A/P-loop; other site 713604024461 ATP binding site [chemical binding]; other site 713604024462 Q-loop/lid; other site 713604024463 ABC transporter signature motif; other site 713604024464 Walker B; other site 713604024465 D-loop; other site 713604024466 H-loop/switch region; other site 713604024467 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604024468 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604024469 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604024470 VanZ like family; Region: VanZ; cl01971 713604024471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604024472 Coenzyme A binding pocket [chemical binding]; other site 713604024473 hypothetical protein; Provisional; Region: PRK09256 713604024474 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 713604024475 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 713604024476 dimerization interface [polypeptide binding]; other site 713604024477 putative ATP binding site [chemical binding]; other site 713604024478 amidophosphoribosyltransferase; Provisional; Region: PRK07847 713604024479 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 713604024480 active site 713604024481 tetramer interface [polypeptide binding]; other site 713604024482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604024483 active site 713604024484 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604024485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604024486 non-specific DNA binding site [nucleotide binding]; other site 713604024487 salt bridge; other site 713604024488 sequence-specific DNA binding site [nucleotide binding]; other site 713604024489 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604024490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 713604024491 S-adenosylmethionine binding site [chemical binding]; other site 713604024492 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 713604024493 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604024494 active site 713604024495 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 713604024496 active site 713604024497 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 713604024498 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 713604024499 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 713604024500 Helix-turn-helix domain; Region: HTH_38; pfam13936 713604024501 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 713604024502 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 713604024503 dimerization interface [polypeptide binding]; other site 713604024504 ATP binding site [chemical binding]; other site 713604024505 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 713604024506 dimerization interface [polypeptide binding]; other site 713604024507 ATP binding site [chemical binding]; other site 713604024508 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604024509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604024510 Walker A/P-loop; other site 713604024511 ATP binding site [chemical binding]; other site 713604024512 ABC transporter; Region: ABC_tran; pfam00005 713604024513 Q-loop/lid; other site 713604024514 ABC transporter signature motif; other site 713604024515 Walker B; other site 713604024516 D-loop; other site 713604024517 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604024518 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 713604024519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604024520 Walker A/P-loop; other site 713604024521 ATP binding site [chemical binding]; other site 713604024522 Q-loop/lid; other site 713604024523 ABC transporter signature motif; other site 713604024524 Walker B; other site 713604024525 D-loop; other site 713604024526 H-loop/switch region; other site 713604024527 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 713604024528 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 713604024529 putative active site [active] 713604024530 catalytic triad [active] 713604024531 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 713604024532 choline dehydrogenase; Validated; Region: PRK02106 713604024533 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 713604024534 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 713604024535 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 713604024536 NAD(P) binding site [chemical binding]; other site 713604024537 catalytic residues [active] 713604024538 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 713604024539 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 713604024540 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 713604024541 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 713604024542 Predicted flavoprotein [General function prediction only]; Region: COG0431 713604024543 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 713604024544 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 713604024545 ATP binding site [chemical binding]; other site 713604024546 active site 713604024547 substrate binding site [chemical binding]; other site 713604024548 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 713604024549 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 713604024550 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 713604024551 Walker A/P-loop; other site 713604024552 ATP binding site [chemical binding]; other site 713604024553 Q-loop/lid; other site 713604024554 ABC transporter signature motif; other site 713604024555 Walker B; other site 713604024556 D-loop; other site 713604024557 H-loop/switch region; other site 713604024558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024559 dimer interface [polypeptide binding]; other site 713604024560 conserved gate region; other site 713604024561 putative PBP binding loops; other site 713604024562 ABC-ATPase subunit interface; other site 713604024563 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604024564 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604024565 substrate binding pocket [chemical binding]; other site 713604024566 membrane-bound complex binding site; other site 713604024567 hinge residues; other site 713604024568 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604024569 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604024570 substrate binding pocket [chemical binding]; other site 713604024571 membrane-bound complex binding site; other site 713604024572 hinge residues; other site 713604024573 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604024574 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604024575 substrate binding pocket [chemical binding]; other site 713604024576 membrane-bound complex binding site; other site 713604024577 hinge residues; other site 713604024578 adenylosuccinate lyase; Region: purB; TIGR00928 713604024579 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 713604024580 tetramer interface [polypeptide binding]; other site 713604024581 galactonate dehydratase; Provisional; Region: PRK14017 713604024582 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 713604024583 metal binding site [ion binding]; metal-binding site 713604024584 substrate binding pocket [chemical binding]; other site 713604024585 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 713604024586 classical (c) SDRs; Region: SDR_c; cd05233 713604024587 NAD(P) binding site [chemical binding]; other site 713604024588 active site 713604024589 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 713604024590 Transcriptional regulators [Transcription]; Region: FadR; COG2186 713604024591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 713604024592 DNA-binding site [nucleotide binding]; DNA binding site 713604024593 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 713604024594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 713604024595 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604024596 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604024597 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604024598 DNA binding residues [nucleotide binding] 713604024599 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 713604024600 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 713604024601 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 713604024602 catalytic residue [active] 713604024603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604024604 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 713604024605 aspartate aminotransferase; Provisional; Region: PRK05764 713604024606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604024607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604024608 homodimer interface [polypeptide binding]; other site 713604024609 catalytic residue [active] 713604024610 Proteins of 100 residues with WXG; Region: WXG100; cl02005 713604024611 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 713604024612 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 713604024613 N-acetyl-D-glucosamine binding site [chemical binding]; other site 713604024614 catalytic residue [active] 713604024615 EspG family; Region: ESX-1_EspG; pfam14011 713604024616 septum formation inhibitor; Reviewed; Region: minC; PRK03511 713604024617 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 713604024618 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 713604024619 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 713604024620 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 713604024621 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 713604024622 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 713604024623 putative active site [active] 713604024624 catalytic site [active] 713604024625 putative metal binding site [ion binding]; other site 713604024626 Beta-lactamase; Region: Beta-lactamase; pfam00144 713604024627 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 713604024628 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 713604024629 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 713604024630 ligand binding site [chemical binding]; other site 713604024631 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604024632 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604024633 substrate binding site [chemical binding]; other site 713604024634 ATP binding site [chemical binding]; other site 713604024635 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 713604024636 dimerization interface [polypeptide binding]; other site 713604024637 active site 713604024638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024639 putative substrate translocation pore; other site 713604024640 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 713604024641 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 713604024642 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 713604024643 OsmC-like protein; Region: OsmC; pfam02566 713604024644 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 713604024645 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 713604024646 GDP-binding site [chemical binding]; other site 713604024647 ACT binding site; other site 713604024648 IMP binding site; other site 713604024649 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 713604024650 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604024651 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 713604024652 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 713604024653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024654 putative substrate translocation pore; other site 713604024655 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604024656 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 713604024657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 713604024658 metal binding site [ion binding]; metal-binding site 713604024659 active site 713604024660 I-site; other site 713604024661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604024662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024663 Secretory lipase; Region: LIP; pfam03583 713604024664 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 713604024665 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 713604024666 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 713604024667 active site 713604024668 intersubunit interface [polypeptide binding]; other site 713604024669 zinc binding site [ion binding]; other site 713604024670 Na+ binding site [ion binding]; other site 713604024671 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 713604024672 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 713604024673 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 713604024674 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 713604024675 active site 713604024676 catalytic tetrad [active] 713604024677 short chain dehydrogenase; Provisional; Region: PRK05872 713604024678 classical (c) SDRs; Region: SDR_c; cd05233 713604024679 NAD(P) binding site [chemical binding]; other site 713604024680 active site 713604024681 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 713604024682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 713604024683 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 713604024684 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 713604024685 FMN-binding pocket [chemical binding]; other site 713604024686 flavin binding motif; other site 713604024687 phosphate binding motif [ion binding]; other site 713604024688 beta-alpha-beta structure motif; other site 713604024689 NAD binding pocket [chemical binding]; other site 713604024690 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 713604024691 catalytic loop [active] 713604024692 iron binding site [ion binding]; other site 713604024693 YCII-related domain; Region: YCII; cl00999 713604024694 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604024695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604024696 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604024697 DNA binding residues [nucleotide binding] 713604024698 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 713604024699 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 713604024700 active site 713604024701 dimer interface [polypeptide binding]; other site 713604024702 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604024703 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604024704 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 713604024705 putative active site [active] 713604024706 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 713604024707 FAD binding domain; Region: FAD_binding_4; pfam01565 713604024708 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 713604024709 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 713604024710 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604024711 MarR family; Region: MarR; pfam01047 713604024712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024713 D-galactonate transporter; Region: 2A0114; TIGR00893 713604024714 putative substrate translocation pore; other site 713604024715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604024716 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604024717 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604024718 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604024719 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604024720 YceI-like domain; Region: YceI; smart00867 713604024721 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 713604024722 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 713604024723 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 713604024724 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 713604024725 active site 713604024726 metal binding site [ion binding]; metal-binding site 713604024727 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 713604024728 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 713604024729 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 713604024730 short chain dehydrogenase; Provisional; Region: PRK06123 713604024731 classical (c) SDRs; Region: SDR_c; cd05233 713604024732 NAD(P) binding site [chemical binding]; other site 713604024733 active site 713604024734 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 713604024735 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 713604024736 active site 713604024737 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 713604024738 substrate binding site [chemical binding]; other site 713604024739 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604024740 ATP binding site [chemical binding]; other site 713604024741 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 713604024742 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 713604024743 Walker A/P-loop; other site 713604024744 ATP binding site [chemical binding]; other site 713604024745 Q-loop/lid; other site 713604024746 ABC transporter signature motif; other site 713604024747 Walker B; other site 713604024748 D-loop; other site 713604024749 H-loop/switch region; other site 713604024750 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 713604024751 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 713604024752 TM-ABC transporter signature motif; other site 713604024753 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 713604024754 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604024755 ligand binding site [chemical binding]; other site 713604024756 Transcriptional regulators [Transcription]; Region: PurR; COG1609 713604024757 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 713604024758 DNA binding site [nucleotide binding] 713604024759 domain linker motif; other site 713604024760 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604024761 ligand binding site [chemical binding]; other site 713604024762 dimerization interface [polypeptide binding]; other site 713604024763 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 713604024764 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 713604024765 ligand binding site [chemical binding]; other site 713604024766 dimerization interface [polypeptide binding]; other site 713604024767 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 713604024768 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 713604024769 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 713604024770 putative [Fe4-S4] binding site [ion binding]; other site 713604024771 putative molybdopterin cofactor binding site [chemical binding]; other site 713604024772 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 713604024773 putative molybdopterin cofactor binding site; other site 713604024774 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 713604024775 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 713604024776 Asp23 family; Region: Asp23; pfam03780 713604024777 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 713604024778 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604024779 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604024780 DNA binding residues [nucleotide binding] 713604024781 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 713604024782 active site 713604024783 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 713604024784 FtsX-like permease family; Region: FtsX; pfam02687 713604024785 FtsX-like permease family; Region: FtsX; pfam02687 713604024786 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604024787 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604024788 Walker A/P-loop; other site 713604024789 ATP binding site [chemical binding]; other site 713604024790 Q-loop/lid; other site 713604024791 ABC transporter signature motif; other site 713604024792 Walker B; other site 713604024793 D-loop; other site 713604024794 H-loop/switch region; other site 713604024795 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 713604024796 classical (c) SDRs; Region: SDR_c; cd05233 713604024797 NAD(P) binding site [chemical binding]; other site 713604024798 active site 713604024799 anthranilate synthase; Provisional; Region: PRK13566 713604024800 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 713604024801 Clp amino terminal domain; Region: Clp_N; pfam02861 713604024802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604024803 Walker A motif; other site 713604024804 ATP binding site [chemical binding]; other site 713604024805 Walker B motif; other site 713604024806 arginine finger; other site 713604024807 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 713604024808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 713604024809 Walker A motif; other site 713604024810 ATP binding site [chemical binding]; other site 713604024811 Walker B motif; other site 713604024812 arginine finger; other site 713604024813 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 713604024814 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604024815 MarR family; Region: MarR_2; pfam12802 713604024816 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 713604024817 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 713604024818 heme-binding site [chemical binding]; other site 713604024819 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 713604024820 FAD binding pocket [chemical binding]; other site 713604024821 FAD binding motif [chemical binding]; other site 713604024822 phosphate binding motif [ion binding]; other site 713604024823 beta-alpha-beta structure motif; other site 713604024824 NAD binding pocket [chemical binding]; other site 713604024825 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 713604024826 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 713604024827 heme-binding site [chemical binding]; other site 713604024828 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 713604024829 FAD binding pocket [chemical binding]; other site 713604024830 FAD binding motif [chemical binding]; other site 713604024831 phosphate binding motif [ion binding]; other site 713604024832 beta-alpha-beta structure motif; other site 713604024833 NAD binding pocket [chemical binding]; other site 713604024834 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 713604024835 Chitin binding domain; Region: Chitin_bind_3; pfam03067 713604024836 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 713604024837 Domain of unknown function (DUF305); Region: DUF305; pfam03713 713604024838 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 713604024839 DNA binding residues [nucleotide binding] 713604024840 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604024841 putative dimer interface [polypeptide binding]; other site 713604024842 chaperone protein DnaJ; Provisional; Region: PRK14295 713604024843 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 713604024844 HSP70 interaction site [polypeptide binding]; other site 713604024845 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 713604024846 Zn binding sites [ion binding]; other site 713604024847 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 713604024848 dimer interface [polypeptide binding]; other site 713604024849 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 713604024850 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 713604024851 dimer interface [polypeptide binding]; other site 713604024852 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 713604024853 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 713604024854 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 713604024855 nucleotide binding site [chemical binding]; other site 713604024856 NEF interaction site [polypeptide binding]; other site 713604024857 SBD interface [polypeptide binding]; other site 713604024858 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 713604024859 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 713604024860 substrate binding site [chemical binding]; other site 713604024861 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 713604024862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604024863 non-specific DNA binding site [nucleotide binding]; other site 713604024864 salt bridge; other site 713604024865 sequence-specific DNA binding site [nucleotide binding]; other site 713604024866 Domain of unknown function (DUF397); Region: DUF397; pfam04149 713604024867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 713604024868 Coenzyme A binding pocket [chemical binding]; other site 713604024869 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 713604024870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024871 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 713604024872 Cysteine-rich domain; Region: CCG; pfam02754 713604024873 Cysteine-rich domain; Region: CCG; pfam02754 713604024874 Protein of unknown function (DUF742); Region: DUF742; pfam05331 713604024875 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 713604024876 Cation efflux family; Region: Cation_efflux; pfam01545 713604024877 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 713604024878 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 713604024879 Domain of unknown function DUF11; Region: DUF11; cl17728 713604024880 Domain of unknown function DUF11; Region: DUF11; pfam01345 713604024881 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604024882 MarR family; Region: MarR; pfam01047 713604024883 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 713604024884 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 713604024885 trimer interface [polypeptide binding]; other site 713604024886 active site 713604024887 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 713604024888 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 713604024889 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 713604024890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604024891 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 713604024892 YCII-related domain; Region: YCII; cl00999 713604024893 Cytochrome P450; Region: p450; cl12078 713604024894 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 713604024895 Domain of unknown function (DUF385); Region: DUF385; cl04387 713604024896 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 713604024897 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 713604024898 Protein of unknown function (DUF419); Region: DUF419; cl15265 713604024899 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 713604024900 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 713604024901 putative active site [active] 713604024902 putative metal binding site [ion binding]; other site 713604024903 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 713604024904 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 713604024905 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 713604024906 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604024907 VanZ like family; Region: VanZ; pfam04892 713604024908 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 713604024909 active site 713604024910 SUMO-1 interface [polypeptide binding]; other site 713604024911 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604024912 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604024913 DNA binding residues [nucleotide binding] 713604024914 dimerization interface [polypeptide binding]; other site 713604024915 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 713604024916 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 713604024917 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 713604024918 FAD binding site [chemical binding]; other site 713604024919 substrate binding site [chemical binding]; other site 713604024920 catalytic residues [active] 713604024921 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 713604024922 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 713604024923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604024924 salt bridge; other site 713604024925 non-specific DNA binding site [nucleotide binding]; other site 713604024926 sequence-specific DNA binding site [nucleotide binding]; other site 713604024927 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 713604024928 Leucine rich repeat; Region: LRR_8; pfam13855 713604024929 Leucine-rich repeats; other site 713604024930 Substrate binding site [chemical binding]; other site 713604024931 Leucine rich repeat; Region: LRR_8; pfam13855 713604024932 Leucine rich repeat; Region: LRR_8; pfam13855 713604024933 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 713604024934 VanW like protein; Region: VanW; pfam04294 713604024935 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 713604024936 oligomerisation interface [polypeptide binding]; other site 713604024937 mobile loop; other site 713604024938 roof hairpin; other site 713604024939 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 713604024940 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 713604024941 NHL repeat; Region: NHL; pfam01436 713604024942 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 713604024943 hydrophobic ligand binding site; other site 713604024944 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 713604024945 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 713604024946 Walker A/P-loop; other site 713604024947 ATP binding site [chemical binding]; other site 713604024948 Q-loop/lid; other site 713604024949 ABC transporter signature motif; other site 713604024950 Walker B; other site 713604024951 D-loop; other site 713604024952 H-loop/switch region; other site 713604024953 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 713604024954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 713604024955 dimer interface [polypeptide binding]; other site 713604024956 conserved gate region; other site 713604024957 putative PBP binding loops; other site 713604024958 ABC-ATPase subunit interface; other site 713604024959 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 713604024960 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 713604024961 substrate binding pocket [chemical binding]; other site 713604024962 membrane-bound complex binding site; other site 713604024963 hinge residues; other site 713604024964 Uncharacterized conserved protein [Function unknown]; Region: COG2308 713604024965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 713604024966 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 713604024967 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 713604024968 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 713604024969 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 713604024970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604024971 NAD(P) binding site [chemical binding]; other site 713604024972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024973 hypothetical protein; Provisional; Region: PRK07907 713604024974 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 713604024975 metal binding site [ion binding]; metal-binding site 713604024976 putative dimer interface [polypeptide binding]; other site 713604024977 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 713604024978 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 713604024979 TPP-binding site [chemical binding]; other site 713604024980 heterodimer interface [polypeptide binding]; other site 713604024981 tetramer interface [polypeptide binding]; other site 713604024982 phosphorylation loop region [posttranslational modification] 713604024983 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 713604024984 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 713604024985 alpha subunit interface [polypeptide binding]; other site 713604024986 TPP binding site [chemical binding]; other site 713604024987 heterodimer interface [polypeptide binding]; other site 713604024988 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 713604024989 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 713604024990 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 713604024991 E3 interaction surface; other site 713604024992 lipoyl attachment site [posttranslational modification]; other site 713604024993 e3 binding domain; Region: E3_binding; pfam02817 713604024994 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 713604024995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604024996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604024997 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 713604024998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604024999 Walker A/P-loop; other site 713604025000 ATP binding site [chemical binding]; other site 713604025001 Q-loop/lid; other site 713604025002 ABC transporter signature motif; other site 713604025003 Walker B; other site 713604025004 D-loop; other site 713604025005 H-loop/switch region; other site 713604025006 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 713604025007 NAD(P) binding site [chemical binding]; other site 713604025008 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 713604025009 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 713604025010 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 713604025011 additional DNA contacts [nucleotide binding]; other site 713604025012 active site 713604025013 zinc binding site [ion binding]; other site 713604025014 DNA intercalation site [nucleotide binding]; other site 713604025015 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 713604025016 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 713604025017 cofactor binding site; other site 713604025018 DNA binding site [nucleotide binding] 713604025019 substrate interaction site [chemical binding]; other site 713604025020 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 713604025021 ATP binding site [chemical binding]; other site 713604025022 putative Mg++ binding site [ion binding]; other site 713604025023 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 713604025024 nucleotide binding region [chemical binding]; other site 713604025025 ATP-binding site [chemical binding]; other site 713604025026 SCP-2 sterol transfer family; Region: SCP2; pfam02036 713604025027 SCP-2 sterol transfer family; Region: SCP2; pfam02036 713604025028 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604025029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604025030 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604025031 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 713604025032 active site 2 [active] 713604025033 active site 1 [active] 713604025034 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 713604025035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604025036 NAD(P) binding site [chemical binding]; other site 713604025037 active site 713604025038 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 713604025039 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 713604025040 dimer interface [polypeptide binding]; other site 713604025041 active site 713604025042 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 713604025043 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 713604025044 DNA binding residues [nucleotide binding] 713604025045 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 713604025046 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 713604025047 AAA ATPase domain; Region: AAA_16; pfam13191 713604025048 Archaeal ATPase; Region: Arch_ATPase; pfam01637 713604025049 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 713604025050 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 713604025051 putative Zn2+ binding site [ion binding]; other site 713604025052 putative DNA binding site [nucleotide binding]; other site 713604025053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604025054 Coenzyme A binding pocket [chemical binding]; other site 713604025055 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 713604025056 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 713604025057 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 713604025058 Na binding site [ion binding]; other site 713604025059 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 713604025060 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 713604025061 TAP-like protein; Region: Abhydrolase_4; pfam08386 713604025062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 713604025063 sequence-specific DNA binding site [nucleotide binding]; other site 713604025064 salt bridge; other site 713604025065 Predicted acetyltransferase [General function prediction only]; Region: COG3393 713604025066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 713604025067 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 713604025068 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 713604025069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 713604025070 Walker A/P-loop; other site 713604025071 ATP binding site [chemical binding]; other site 713604025072 Q-loop/lid; other site 713604025073 ABC transporter signature motif; other site 713604025074 Walker B; other site 713604025075 D-loop; other site 713604025076 H-loop/switch region; other site 713604025077 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604025078 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604025079 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 713604025080 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 713604025081 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 713604025082 active site 713604025083 substrate-binding site [chemical binding]; other site 713604025084 metal-binding site [ion binding] 713604025085 GTP binding site [chemical binding]; other site 713604025086 Dynamin family; Region: Dynamin_N; pfam00350 713604025087 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604025088 G1 box; other site 713604025089 GTP/Mg2+ binding site [chemical binding]; other site 713604025090 G2 box; other site 713604025091 Switch I region; other site 713604025092 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604025093 G3 box; other site 713604025094 Switch II region; other site 713604025095 GTP/Mg2+ binding site [chemical binding]; other site 713604025096 G4 box; other site 713604025097 G5 box; other site 713604025098 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 713604025099 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 713604025100 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 713604025101 G1 box; other site 713604025102 GTP/Mg2+ binding site [chemical binding]; other site 713604025103 G2 box; other site 713604025104 Switch I region; other site 713604025105 G3 box; other site 713604025106 Switch II region; other site 713604025107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604025108 Histidine kinase; Region: HisKA_3; pfam07730 713604025109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 713604025110 ATP binding site [chemical binding]; other site 713604025111 Mg2+ binding site [ion binding]; other site 713604025112 G-X-G motif; other site 713604025113 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604025114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604025115 active site 713604025116 phosphorylation site [posttranslational modification] 713604025117 intermolecular recognition site; other site 713604025118 dimerization interface [polypeptide binding]; other site 713604025119 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604025120 DNA binding residues [nucleotide binding] 713604025121 dimerization interface [polypeptide binding]; other site 713604025122 short chain dehydrogenase; Provisional; Region: PRK08303 713604025123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 713604025124 NAD(P) binding site [chemical binding]; other site 713604025125 active site 713604025126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604025127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 713604025128 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604025129 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 713604025130 Walker A/P-loop; other site 713604025131 ATP binding site [chemical binding]; other site 713604025132 Q-loop/lid; other site 713604025133 ABC transporter signature motif; other site 713604025134 Walker B; other site 713604025135 D-loop; other site 713604025136 H-loop/switch region; other site 713604025137 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604025138 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 713604025139 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 713604025140 Walker A/P-loop; other site 713604025141 ATP binding site [chemical binding]; other site 713604025142 Q-loop/lid; other site 713604025143 ABC transporter signature motif; other site 713604025144 Walker B; other site 713604025145 D-loop; other site 713604025146 H-loop/switch region; other site 713604025147 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 713604025148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 713604025149 S-adenosylmethionine binding site [chemical binding]; other site 713604025150 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 713604025151 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 713604025152 Walker A/P-loop; other site 713604025153 ATP binding site [chemical binding]; other site 713604025154 Q-loop/lid; other site 713604025155 ABC transporter signature motif; other site 713604025156 Walker B; other site 713604025157 D-loop; other site 713604025158 H-loop/switch region; other site 713604025159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604025160 Histidine kinase; Region: HisKA_3; pfam07730 713604025161 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604025162 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604025163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604025164 active site 713604025165 phosphorylation site [posttranslational modification] 713604025166 intermolecular recognition site; other site 713604025167 dimerization interface [polypeptide binding]; other site 713604025168 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604025169 DNA binding residues [nucleotide binding] 713604025170 dimerization interface [polypeptide binding]; other site 713604025171 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 713604025172 active site 713604025173 putative substrate binding pocket [chemical binding]; other site 713604025174 short chain dehydrogenase; Provisional; Region: PRK08219 713604025175 classical (c) SDRs; Region: SDR_c; cd05233 713604025176 NAD(P) binding site [chemical binding]; other site 713604025177 active site 713604025178 Domain of unknown function DUF11; Region: DUF11; pfam01345 713604025179 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 713604025180 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 713604025181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604025182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 713604025183 putative substrate translocation pore; other site 713604025184 MarR family; Region: MarR; pfam01047 713604025185 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 713604025186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 713604025187 motif II; other site 713604025188 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 713604025189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604025190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604025191 DNA binding residues [nucleotide binding] 713604025192 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 713604025193 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 713604025194 Predicted transcriptional regulators [Transcription]; Region: COG1695 713604025195 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 713604025196 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 713604025197 Transglycosylase; Region: Transgly; pfam00912 713604025198 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604025199 Transglycosylase; Region: Transgly; pfam00912 713604025200 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 713604025201 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 713604025202 putative oxidoreductase; Provisional; Region: PRK11579 713604025203 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 713604025204 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 713604025205 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604025206 MarR family; Region: MarR_2; pfam12802 713604025207 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 713604025208 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 713604025209 Predicted integral membrane protein [Function unknown]; Region: COG5650 713604025210 endonuclease IV; Provisional; Region: PRK01060 713604025211 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 713604025212 AP (apurinic/apyrimidinic) site pocket; other site 713604025213 DNA interaction; other site 713604025214 Metal-binding active site; metal-binding site 713604025215 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 713604025216 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 713604025217 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 713604025218 dimer interface [polypeptide binding]; other site 713604025219 ssDNA binding site [nucleotide binding]; other site 713604025220 tetramer (dimer of dimers) interface [polypeptide binding]; other site 713604025221 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 713604025222 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 713604025223 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 713604025224 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 713604025225 EspG family; Region: ESX-1_EspG; pfam14011 713604025226 replicative DNA helicase; Region: DnaB; TIGR00665 713604025227 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 713604025228 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 713604025229 Walker A motif; other site 713604025230 ATP binding site [chemical binding]; other site 713604025231 Walker B motif; other site 713604025232 DNA binding loops [nucleotide binding] 713604025233 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604025234 MarR family; Region: MarR_2; pfam12802 713604025235 Transcriptional regulators [Transcription]; Region: MarR; COG1846 713604025236 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 713604025237 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 713604025238 putative active site [active] 713604025239 metal binding site [ion binding]; metal-binding site 713604025240 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 713604025241 Domain of unknown function DUF20; Region: UPF0118; pfam01594 713604025242 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604025243 ATP binding site [chemical binding]; other site 713604025244 G-X-G motif; other site 713604025245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 713604025246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 713604025247 active site 713604025248 phosphorylation site [posttranslational modification] 713604025249 intermolecular recognition site; other site 713604025250 dimerization interface [polypeptide binding]; other site 713604025251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 713604025252 DNA binding residues [nucleotide binding] 713604025253 dimerization interface [polypeptide binding]; other site 713604025254 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 713604025255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 713604025256 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 713604025257 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 713604025258 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 713604025259 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 713604025260 ParB-like nuclease domain; Region: ParBc; cl02129 713604025261 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 713604025262 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 713604025263 substrate binding site [chemical binding]; other site 713604025264 dimer interface [polypeptide binding]; other site 713604025265 ATP binding site [chemical binding]; other site 713604025266 EspG family; Region: ESX-1_EspG; pfam14011 713604025267 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 713604025268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 713604025269 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 713604025270 DNA-binding interface [nucleotide binding]; DNA binding site 713604025271 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 713604025272 classical (c) SDRs; Region: SDR_c; cd05233 713604025273 NAD(P) binding site [chemical binding]; other site 713604025274 active site 713604025275 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 713604025276 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604025277 active site 713604025278 HIGH motif; other site 713604025279 nucleotide binding site [chemical binding]; other site 713604025280 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 713604025281 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604025282 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 713604025283 active site 713604025284 KMSKS motif; other site 713604025285 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 713604025286 tRNA binding surface [nucleotide binding]; other site 713604025287 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 713604025288 SdpI/YhfL protein family; Region: SdpI; pfam13630 713604025289 hypothetical protein; Validated; Region: PRK00228 713604025290 H+ Antiporter protein; Region: 2A0121; TIGR00900 713604025291 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 713604025292 active site 713604025293 conformational flexibility of ligand binding pocket; other site 713604025294 ADP-ribosylating toxin turn-turn motif; other site 713604025295 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 713604025296 Region found in RelA / SpoT proteins; Region: RelA_SpoT; smart00954 713604025297 metal binding triad [ion binding]; metal-binding site 713604025298 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 713604025299 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 713604025300 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 713604025301 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 713604025302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 713604025303 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 713604025304 ATP binding site [chemical binding]; other site 713604025305 Mg2+ binding site [ion binding]; other site 713604025306 G-X-G motif; other site 713604025307 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 713604025308 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 713604025309 active site 713604025310 NTP binding site [chemical binding]; other site 713604025311 metal binding triad [ion binding]; metal-binding site 713604025312 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 713604025313 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 713604025314 Zn2+ binding site [ion binding]; other site 713604025315 Mg2+ binding site [ion binding]; other site 713604025316 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 713604025317 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 713604025318 active site 713604025319 Ap6A binding site [chemical binding]; other site 713604025320 nudix motif; other site 713604025321 metal binding site [ion binding]; metal-binding site 713604025322 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 713604025323 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 713604025324 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 713604025325 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 713604025326 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 713604025327 DNA binding residues [nucleotide binding] 713604025328 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 713604025329 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 713604025330 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 713604025331 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 713604025332 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 713604025333 catalytic residues [active] 713604025334 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 713604025335 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604025336 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 713604025337 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 713604025338 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 713604025339 active site 713604025340 metal binding site [ion binding]; metal-binding site 713604025341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 713604025342 Coenzyme A binding pocket [chemical binding]; other site 713604025343 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 713604025344 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 713604025345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 713604025346 homodimer interface [polypeptide binding]; other site 713604025347 catalytic residue [active] 713604025348 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 713604025349 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 713604025350 ATP-grasp domain; Region: ATP-grasp_4; cl17255 713604025351 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 713604025352 ParB-like nuclease domain; Region: ParBc; pfam02195 713604025353 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 713604025354 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604025355 P-loop; other site 713604025356 Magnesium ion binding site [ion binding]; other site 713604025357 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 713604025358 Magnesium ion binding site [ion binding]; other site 713604025359 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 713604025360 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 713604025361 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 713604025362 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 713604025363 G-X-X-G motif; other site 713604025364 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 713604025365 RxxxH motif; other site 713604025366 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 713604025367 Haemolytic domain; Region: Haemolytic; pfam01809 713604025368 Ribosomal protein L34; Region: Ribosomal_L34; cl00370