-- dump date 20140618_203116 -- class Genbank::misc_feature -- table misc_feature_note -- id note 749927000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 749927000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927000003 Walker A motif; other site 749927000004 ATP binding site [chemical binding]; other site 749927000005 Walker B motif; other site 749927000006 arginine finger; other site 749927000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 749927000008 DnaA box-binding interface [nucleotide binding]; other site 749927000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 749927000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 749927000011 putative DNA binding surface [nucleotide binding]; other site 749927000012 dimer interface [polypeptide binding]; other site 749927000013 beta-clamp/clamp loader binding surface; other site 749927000014 beta-clamp/translesion DNA polymerase binding surface; other site 749927000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 749927000016 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 749927000017 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 749927000018 recombination protein F; Reviewed; Region: recF; PRK00064 749927000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927000020 Walker A/P-loop; other site 749927000021 ATP binding site [chemical binding]; other site 749927000022 Q-loop/lid; other site 749927000023 ABC transporter signature motif; other site 749927000024 Walker B; other site 749927000025 D-loop; other site 749927000026 H-loop/switch region; other site 749927000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 749927000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 749927000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927000030 ATP binding site [chemical binding]; other site 749927000031 Mg2+ binding site [ion binding]; other site 749927000032 G-X-G motif; other site 749927000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 749927000034 anchoring element; other site 749927000035 dimer interface [polypeptide binding]; other site 749927000036 ATP binding site [chemical binding]; other site 749927000037 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 749927000038 active site 749927000039 metal binding site [ion binding]; metal-binding site 749927000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 749927000041 DNA gyrase subunit A; Validated; Region: PRK05560 749927000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 749927000043 CAP-like domain; other site 749927000044 active site 749927000045 primary dimer interface [polypeptide binding]; other site 749927000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749927000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749927000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749927000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749927000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749927000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749927000052 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 749927000053 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 749927000054 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 749927000055 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749927000056 active site 749927000057 DNA binding site [nucleotide binding] 749927000058 Int/Topo IB signature motif; other site 749927000059 Helix-turn-helix domain; Region: HTH_17; cl17695 749927000060 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 749927000061 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927000062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927000063 non-specific DNA binding site [nucleotide binding]; other site 749927000064 salt bridge; other site 749927000065 sequence-specific DNA binding site [nucleotide binding]; other site 749927000066 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927000067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927000068 non-specific DNA binding site [nucleotide binding]; other site 749927000069 salt bridge; other site 749927000070 sequence-specific DNA binding site [nucleotide binding]; other site 749927000071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927000072 Walker A motif; other site 749927000073 ATP binding site [chemical binding]; other site 749927000074 Walker B motif; other site 749927000075 HEAT repeats; Region: HEAT_2; pfam13646 749927000076 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927000077 active site 749927000078 metal binding site [ion binding]; metal-binding site 749927000079 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 749927000080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927000081 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 749927000082 Walker A/P-loop; other site 749927000083 ATP binding site [chemical binding]; other site 749927000084 Q-loop/lid; other site 749927000085 ABC transporter signature motif; other site 749927000086 Walker B; other site 749927000087 D-loop; other site 749927000088 H-loop/switch region; other site 749927000089 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927000090 ABC-2 type transporter; Region: ABC2_membrane; cl17235 749927000091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927000092 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927000093 DNA binding site [nucleotide binding] 749927000094 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927000095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927000096 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927000097 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927000098 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927000099 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927000100 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 749927000101 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 749927000102 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 749927000103 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 749927000104 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 749927000105 active site 749927000106 Rhomboid family; Region: Rhomboid; pfam01694 749927000107 Bacterial PH domain; Region: bPH_6; pfam10756 749927000108 putative septation inhibitor protein; Reviewed; Region: PRK00159 749927000109 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 749927000110 active site 749927000111 catalytic site [active] 749927000112 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927000113 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 749927000114 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 749927000115 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927000116 Walker A/P-loop; other site 749927000117 ATP binding site [chemical binding]; other site 749927000118 Q-loop/lid; other site 749927000119 ABC transporter signature motif; other site 749927000120 Walker B; other site 749927000121 D-loop; other site 749927000122 H-loop/switch region; other site 749927000123 Putative sensor; Region: Sensor; pfam13796 749927000124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927000125 Histidine kinase; Region: HisKA_3; pfam07730 749927000126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927000127 ATP binding site [chemical binding]; other site 749927000128 Mg2+ binding site [ion binding]; other site 749927000129 G-X-G motif; other site 749927000130 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927000131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927000132 active site 749927000133 phosphorylation site [posttranslational modification] 749927000134 intermolecular recognition site; other site 749927000135 dimerization interface [polypeptide binding]; other site 749927000136 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927000137 DNA binding residues [nucleotide binding] 749927000138 dimerization interface [polypeptide binding]; other site 749927000139 ferredoxin-NADP+ reductase; Region: PLN02852 749927000140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927000141 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 749927000142 Glutamine amidotransferase class-I; Region: GATase; pfam00117 749927000143 glutamine binding [chemical binding]; other site 749927000144 catalytic triad [active] 749927000145 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927000146 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927000147 Walker A/P-loop; other site 749927000148 ATP binding site [chemical binding]; other site 749927000149 Q-loop/lid; other site 749927000150 ABC transporter signature motif; other site 749927000151 Walker B; other site 749927000152 D-loop; other site 749927000153 H-loop/switch region; other site 749927000154 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927000155 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927000156 active site 749927000157 ATP binding site [chemical binding]; other site 749927000158 substrate binding site [chemical binding]; other site 749927000159 activation loop (A-loop); other site 749927000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 749927000161 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 749927000162 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 749927000163 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 749927000164 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 749927000165 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927000166 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927000167 active site 749927000168 ATP binding site [chemical binding]; other site 749927000169 substrate binding site [chemical binding]; other site 749927000170 activation loop (A-loop); other site 749927000171 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 749927000172 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 749927000173 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 749927000174 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 749927000175 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 749927000176 active site 749927000177 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 749927000178 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 749927000179 phosphopeptide binding site; other site 749927000180 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 749927000181 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 749927000182 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 749927000183 phosphopeptide binding site; other site 749927000184 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 749927000185 cleavage site 749927000186 active site 749927000187 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 749927000188 Trypsin-like serine protease; Region: Tryp_SPc; smart00020 749927000189 active site 749927000190 substrate binding sites [chemical binding]; other site 749927000191 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 749927000192 Penicillin amidase; Region: Penicil_amidase; pfam01804 749927000193 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 749927000194 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 749927000195 active site 749927000196 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927000197 sugar binding site [chemical binding]; other site 749927000198 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927000199 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927000200 catalytic residue [active] 749927000201 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 749927000202 active site 749927000203 putative catalytic site [active] 749927000204 Patatin-like phospholipase; Region: Patatin; pfam01734 749927000205 nucleophile elbow; other site 749927000206 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927000207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927000208 DNA-binding site [nucleotide binding]; DNA binding site 749927000209 FCD domain; Region: FCD; pfam07729 749927000210 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 749927000211 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 749927000212 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 749927000213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927000214 dimer interface [polypeptide binding]; other site 749927000215 conserved gate region; other site 749927000216 putative PBP binding loops; other site 749927000217 ABC-ATPase subunit interface; other site 749927000218 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 749927000219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927000220 dimer interface [polypeptide binding]; other site 749927000221 conserved gate region; other site 749927000222 putative PBP binding loops; other site 749927000223 ABC-ATPase subunit interface; other site 749927000224 potential frameshift: common BLAST hit: gi|269957919|ref|YP_003327708.1| ABC transporter related protein 749927000225 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 749927000226 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927000227 Walker A/P-loop; other site 749927000228 ATP binding site [chemical binding]; other site 749927000229 Q-loop/lid; other site 749927000230 ABC transporter signature motif; other site 749927000231 Walker B; other site 749927000232 D-loop; other site 749927000233 H-loop/switch region; other site 749927000234 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927000235 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 749927000236 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927000237 Walker A/P-loop; other site 749927000238 ATP binding site [chemical binding]; other site 749927000239 Q-loop/lid; other site 749927000240 ABC transporter signature motif; other site 749927000241 Walker B; other site 749927000242 D-loop; other site 749927000243 H-loop/switch region; other site 749927000244 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927000245 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927000246 NAD(P) binding site [chemical binding]; other site 749927000247 catalytic residues [active] 749927000248 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927000249 classical (c) SDRs; Region: SDR_c; cd05233 749927000250 NAD(P) binding site [chemical binding]; other site 749927000251 active site 749927000252 amidase; Provisional; Region: PRK07042 749927000253 Transposase; Region: DEDD_Tnp_IS110; pfam01548 749927000254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 749927000255 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 749927000256 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927000257 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927000258 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927000259 DNA binding residues [nucleotide binding] 749927000260 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 749927000261 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 749927000262 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927000263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927000264 NAD(P) binding site [chemical binding]; other site 749927000265 active site 749927000266 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 749927000267 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 749927000268 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927000269 active site 749927000270 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 749927000271 FAD binding domain; Region: FAD_binding_4; pfam01565 749927000272 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 749927000273 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 749927000274 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 749927000275 dimer interface [polypeptide binding]; other site 749927000276 active site 749927000277 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749927000278 substrate binding site [chemical binding]; other site 749927000279 catalytic residue [active] 749927000280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927000281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927000282 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 749927000283 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 749927000284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927000285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927000286 putative substrate translocation pore; other site 749927000287 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927000288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927000289 salt bridge; other site 749927000290 non-specific DNA binding site [nucleotide binding]; other site 749927000291 sequence-specific DNA binding site [nucleotide binding]; other site 749927000292 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; cl19828 749927000293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927000294 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927000295 Phosphotransferase enzyme family; Region: APH; pfam01636 749927000296 active site 749927000297 ATP binding site [chemical binding]; other site 749927000298 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 749927000299 Copper resistance protein D; Region: CopD; cl00563 749927000300 CopC domain; Region: CopC; pfam04234 749927000301 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 749927000302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927000303 dimer interface [polypeptide binding]; other site 749927000304 conserved gate region; other site 749927000305 putative PBP binding loops; other site 749927000306 ABC-ATPase subunit interface; other site 749927000307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927000308 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 749927000309 Walker A/P-loop; other site 749927000310 ATP binding site [chemical binding]; other site 749927000311 Q-loop/lid; other site 749927000312 ABC transporter signature motif; other site 749927000313 Walker B; other site 749927000314 D-loop; other site 749927000315 H-loop/switch region; other site 749927000316 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 749927000317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927000318 dimer interface [polypeptide binding]; other site 749927000319 conserved gate region; other site 749927000320 putative PBP binding loops; other site 749927000321 ABC-ATPase subunit interface; other site 749927000322 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927000323 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 749927000324 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 749927000325 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927000326 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749927000327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927000328 S-adenosylmethionine binding site [chemical binding]; other site 749927000329 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 749927000330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927000331 NAD(P) binding site [chemical binding]; other site 749927000332 active site 749927000333 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 749927000334 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 749927000335 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 749927000336 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 749927000337 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927000338 active site 749927000339 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 749927000340 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 749927000341 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 749927000342 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 749927000343 Transposase [DNA replication, recombination, and repair]; Region: COG5433 749927000344 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 749927000345 putative dimer interface [polypeptide binding]; other site 749927000346 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927000347 active site 749927000348 metal binding site [ion binding]; metal-binding site 749927000349 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927000350 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927000351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 749927000352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927000353 putative transporter; Provisional; Region: PRK10504 749927000354 putative substrate translocation pore; other site 749927000355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927000356 salt bridge; other site 749927000357 non-specific DNA binding site [nucleotide binding]; other site 749927000358 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927000359 sequence-specific DNA binding site [nucleotide binding]; other site 749927000360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927000361 Histidine kinase; Region: HisKA_3; pfam07730 749927000362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927000363 ATP binding site [chemical binding]; other site 749927000364 Mg2+ binding site [ion binding]; other site 749927000365 G-X-G motif; other site 749927000366 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927000367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927000368 active site 749927000369 phosphorylation site [posttranslational modification] 749927000370 intermolecular recognition site; other site 749927000371 dimerization interface [polypeptide binding]; other site 749927000372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927000373 DNA binding residues [nucleotide binding] 749927000374 dimerization interface [polypeptide binding]; other site 749927000375 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 749927000376 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 749927000377 NADP-binding site; other site 749927000378 homotetramer interface [polypeptide binding]; other site 749927000379 substrate binding site [chemical binding]; other site 749927000380 homodimer interface [polypeptide binding]; other site 749927000381 active site 749927000382 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 749927000383 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927000384 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927000385 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927000386 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927000387 HemX; Region: HemX; cl19375 749927000388 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927000389 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927000390 helicase-primase primase subunit; Provisional; Region: PHA03145 749927000391 large tegument protein UL36; Provisional; Region: PHA03247 749927000392 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927000393 Probable pheophorbidase; Region: PLN02965; cl17657 749927000394 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 749927000395 Immunity protein 46; Region: Imm46; pfam15585 749927000396 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927000397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927000398 Putative zinc-finger; Region: zf-HC2; pfam13490 749927000399 Alkali metal cation/H+ antiporter Nha1 C terminus; Region: Nha1_C; pfam08619 749927000400 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 749927000401 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 749927000402 putative DNA binding site [nucleotide binding]; other site 749927000403 catalytic residue [active] 749927000404 putative H2TH interface [polypeptide binding]; other site 749927000405 putative catalytic residues [active] 749927000406 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 749927000407 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 749927000408 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 749927000409 Histidine kinase; Region: His_kinase; pfam06580 749927000410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927000411 ATP binding site [chemical binding]; other site 749927000412 Mg2+ binding site [ion binding]; other site 749927000413 G-X-G motif; other site 749927000414 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 749927000415 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 749927000416 tandem repeat interface [polypeptide binding]; other site 749927000417 oligomer interface [polypeptide binding]; other site 749927000418 active site residues [active] 749927000419 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 749927000420 active site 749927000421 catalytic residues [active] 749927000422 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 749927000423 metal binding site [ion binding]; metal-binding site 749927000424 ligand binding site [chemical binding]; other site 749927000425 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 749927000426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927000427 active site 749927000428 phosphorylation site [posttranslational modification] 749927000429 intermolecular recognition site; other site 749927000430 dimerization interface [polypeptide binding]; other site 749927000431 LytTr DNA-binding domain; Region: LytTR; smart00850 749927000432 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 749927000433 Na binding site [ion binding]; other site 749927000434 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 749927000435 active site residue [active] 749927000436 YppG-like protein; Region: YppG; pfam14179 749927000437 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 749927000438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927000439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927000440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927000441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927000442 putative substrate translocation pore; other site 749927000443 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 749927000444 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927000445 Protein of unknown function (DUF952); Region: DUF952; pfam06108 749927000446 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927000447 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927000448 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927000449 DNA binding residues [nucleotide binding] 749927000450 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 749927000451 Ferritin-like domain; Region: Ferritin; pfam00210 749927000452 ferroxidase diiron center [ion binding]; other site 749927000453 arginine deiminase; Provisional; Region: PRK01388 749927000454 CAAX protease self-immunity; Region: Abi; pfam02517 749927000455 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 749927000456 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 749927000457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927000458 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927000459 putative substrate translocation pore; other site 749927000460 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 749927000461 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 749927000462 metal ion-dependent adhesion site (MIDAS); other site 749927000463 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 749927000464 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927000465 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927000466 Protein of unknown function (DUF998); Region: DUF998; pfam06197 749927000467 Predicted membrane protein [Function unknown]; Region: COG2119 749927000468 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 749927000469 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 749927000470 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 749927000471 active site triad [active] 749927000472 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 749927000473 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 749927000474 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 749927000475 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 749927000476 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927000477 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 749927000478 Walker A/P-loop; other site 749927000479 ATP binding site [chemical binding]; other site 749927000480 Q-loop/lid; other site 749927000481 ABC transporter signature motif; other site 749927000482 Walker B; other site 749927000483 D-loop; other site 749927000484 H-loop/switch region; other site 749927000485 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 749927000486 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 749927000487 Walker A/P-loop; other site 749927000488 ATP binding site [chemical binding]; other site 749927000489 Q-loop/lid; other site 749927000490 ABC transporter signature motif; other site 749927000491 Walker B; other site 749927000492 D-loop; other site 749927000493 H-loop/switch region; other site 749927000494 GAF domain; Region: GAF; pfam01590 749927000495 Histidine kinase; Region: HisKA_3; pfam07730 749927000496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927000497 ATP binding site [chemical binding]; other site 749927000498 Mg2+ binding site [ion binding]; other site 749927000499 G-X-G motif; other site 749927000500 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927000501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927000502 active site 749927000503 phosphorylation site [posttranslational modification] 749927000504 intermolecular recognition site; other site 749927000505 dimerization interface [polypeptide binding]; other site 749927000506 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927000507 DNA binding residues [nucleotide binding] 749927000508 dimerization interface [polypeptide binding]; other site 749927000509 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 749927000510 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 749927000511 active site 749927000512 putative catalytic site [active] 749927000513 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 749927000514 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 749927000515 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 749927000516 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 749927000517 active site 749927000518 catalytic site [active] 749927000519 substrate binding site [chemical binding]; other site 749927000520 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 749927000521 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 749927000522 homodimer interface [polypeptide binding]; other site 749927000523 chemical substrate binding site [chemical binding]; other site 749927000524 oligomer interface [polypeptide binding]; other site 749927000525 metal binding site [ion binding]; metal-binding site 749927000526 Nitrate and nitrite sensing; Region: NIT; pfam08376 749927000527 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 749927000528 ATP-binding site [chemical binding]; other site 749927000529 CoA-binding site [chemical binding]; other site 749927000530 Mg2+-binding site [ion binding]; other site 749927000531 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 749927000532 ADP-ribose binding site [chemical binding]; other site 749927000533 prephenate dehydratase; Provisional; Region: PRK11898 749927000534 Prephenate dehydratase; Region: PDT; pfam00800 749927000535 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 749927000536 putative L-Phe binding site [chemical binding]; other site 749927000537 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927000538 catalytic core [active] 749927000539 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 749927000540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927000541 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927000542 putative substrate translocation pore; other site 749927000543 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 749927000544 Septum formation; Region: Septum_form; pfam13845 749927000545 Septum formation; Region: Septum_form; pfam13845 749927000546 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 749927000547 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 749927000548 haloalkane dehalogenase; Provisional; Region: PRK00870 749927000549 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927000550 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927000551 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927000552 inhibitor-cofactor binding pocket; inhibition site 749927000553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927000554 catalytic residue [active] 749927000555 seryl-tRNA synthetase; Provisional; Region: PRK05431 749927000556 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 749927000557 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 749927000558 dimer interface [polypeptide binding]; other site 749927000559 active site 749927000560 motif 1; other site 749927000561 motif 2; other site 749927000562 motif 3; other site 749927000563 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 749927000564 Predicted dehydrogenase [General function prediction only]; Region: COG0579 749927000565 hydroxyglutarate oxidase; Provisional; Region: PRK11728 749927000566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927000567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927000568 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927000569 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927000570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927000571 non-specific DNA binding site [nucleotide binding]; other site 749927000572 salt bridge; other site 749927000573 sequence-specific DNA binding site [nucleotide binding]; other site 749927000574 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927000575 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927000576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927000577 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927000578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927000579 binding surface 749927000580 TPR motif; other site 749927000581 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 749927000582 inhibitor-cofactor binding pocket; inhibition site 749927000583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927000584 catalytic residue [active] 749927000585 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927000586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927000587 NAD(P) binding site [chemical binding]; other site 749927000588 active site 749927000589 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927000590 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 749927000591 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 749927000592 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 749927000593 trimer interface [polypeptide binding]; other site 749927000594 active site 749927000595 substrate binding site [chemical binding]; other site 749927000596 CoA binding site [chemical binding]; other site 749927000597 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927000598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927000599 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927000600 DNA binding residues [nucleotide binding] 749927000601 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 749927000602 putative metal binding site [ion binding]; other site 749927000603 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927000604 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927000605 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927000606 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 749927000607 inhibitor-cofactor binding pocket; inhibition site 749927000608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927000609 catalytic residue [active] 749927000610 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 749927000611 putative trimer interface [polypeptide binding]; other site 749927000612 putative CoA binding site [chemical binding]; other site 749927000613 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 749927000614 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927000615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927000616 NAD(P) binding site [chemical binding]; other site 749927000617 active site 749927000618 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927000619 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927000620 acyl-activating enzyme (AAE) consensus motif; other site 749927000621 AMP binding site [chemical binding]; other site 749927000622 active site 749927000623 CoA binding site [chemical binding]; other site 749927000624 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 749927000625 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927000626 NAD(P) binding site [chemical binding]; other site 749927000627 catalytic residues [active] 749927000628 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 749927000629 stage II sporulation protein E; Region: spore_II_E; TIGR02865 749927000630 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 749927000631 putative acyl-acceptor binding pocket; other site 749927000632 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 749927000633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927000634 active site 749927000635 motif I; other site 749927000636 motif II; other site 749927000637 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 749927000638 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 749927000639 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 749927000640 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927000641 UDP-galactopyranose mutase; Region: GLF; pfam03275 749927000642 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 749927000643 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 749927000644 active site 749927000645 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 749927000646 putative active site [active] 749927000647 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 749927000648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927000649 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 749927000650 NAD(P) binding site [chemical binding]; other site 749927000651 active site 749927000652 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927000653 FAD binding domain; Region: FAD_binding_4; pfam01565 749927000654 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 749927000655 GtrA-like protein; Region: GtrA; pfam04138 749927000656 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 749927000657 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927000658 active site 749927000659 EspG family; Region: ESX-1_EspG; pfam14011 749927000660 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 749927000661 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927000662 active site 749927000663 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 749927000664 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 749927000665 Walker A/P-loop; other site 749927000666 ATP binding site [chemical binding]; other site 749927000667 Q-loop/lid; other site 749927000668 ABC transporter signature motif; other site 749927000669 Walker B; other site 749927000670 D-loop; other site 749927000671 H-loop/switch region; other site 749927000672 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 749927000673 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 749927000674 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927000675 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927000676 catalytic residue [active] 749927000677 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 749927000678 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 749927000679 NAD(P) binding site [chemical binding]; other site 749927000680 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 749927000681 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 749927000682 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 749927000683 PA/protease or protease-like domain interface [polypeptide binding]; other site 749927000684 active site 749927000685 metal binding site [ion binding]; metal-binding site 749927000686 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 749927000687 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927000688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927000689 putative DNA binding site [nucleotide binding]; other site 749927000690 putative Zn2+ binding site [ion binding]; other site 749927000691 Patatin-like phospholipase; Region: Patatin; pfam01734 749927000692 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 749927000693 active site 749927000694 nucleophile elbow; other site 749927000695 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927000696 active site 749927000697 metal binding site [ion binding]; metal-binding site 749927000698 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 749927000699 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 749927000700 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749927000701 RNA binding surface [nucleotide binding]; other site 749927000702 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 749927000703 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 749927000704 classical (c) SDRs; Region: SDR_c; cd05233 749927000705 NAD(P) binding site [chemical binding]; other site 749927000706 active site 749927000707 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 749927000708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927000709 active site 749927000710 phosphorylation site [posttranslational modification] 749927000711 intermolecular recognition site; other site 749927000712 dimerization interface [polypeptide binding]; other site 749927000713 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 749927000714 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 749927000715 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 749927000716 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 749927000717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927000718 ATP binding site [chemical binding]; other site 749927000719 Mg2+ binding site [ion binding]; other site 749927000720 G-X-G motif; other site 749927000721 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 749927000722 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 749927000723 Walker A/P-loop; other site 749927000724 ATP binding site [chemical binding]; other site 749927000725 Q-loop/lid; other site 749927000726 ABC transporter signature motif; other site 749927000727 Walker B; other site 749927000728 D-loop; other site 749927000729 H-loop/switch region; other site 749927000730 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749927000731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927000732 dimer interface [polypeptide binding]; other site 749927000733 conserved gate region; other site 749927000734 putative PBP binding loops; other site 749927000735 ABC-ATPase subunit interface; other site 749927000736 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749927000737 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927000738 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 749927000739 polypeptide substrate binding site [polypeptide binding]; other site 749927000740 active site 749927000741 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 749927000742 AAA ATPase domain; Region: AAA_16; pfam13191 749927000743 Predicted ATPase [General function prediction only]; Region: COG3899 749927000744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927000745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927000746 DNA binding residues [nucleotide binding] 749927000747 dimerization interface [polypeptide binding]; other site 749927000748 Trypsin; Region: Trypsin; pfam00089 749927000749 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 749927000750 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927000751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927000752 putative DNA binding site [nucleotide binding]; other site 749927000753 putative Zn2+ binding site [ion binding]; other site 749927000754 AsnC family; Region: AsnC_trans_reg; pfam01037 749927000755 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 749927000756 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 749927000757 dimer interface [polypeptide binding]; other site 749927000758 active site 749927000759 CoA binding pocket [chemical binding]; other site 749927000760 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 749927000761 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927000762 dimerization interface [polypeptide binding]; other site 749927000763 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 749927000764 cyclase homology domain; Region: CHD; cd07302 749927000765 nucleotidyl binding site; other site 749927000766 metal binding site [ion binding]; metal-binding site 749927000767 dimer interface [polypeptide binding]; other site 749927000768 Leucine carboxyl methyltransferase; Region: LCM; cl01306 749927000769 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927000770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927000771 DNA-binding site [nucleotide binding]; DNA binding site 749927000772 FCD domain; Region: FCD; pfam07729 749927000773 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 749927000774 putative aminotransferase; Provisional; Region: PRK03321 749927000775 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927000776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927000777 homodimer interface [polypeptide binding]; other site 749927000778 catalytic residue [active] 749927000779 Dienelactone hydrolase family; Region: DLH; pfam01738 749927000780 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 749927000781 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927000782 acyl-activating enzyme (AAE) consensus motif; other site 749927000783 AMP binding site [chemical binding]; other site 749927000784 active site 749927000785 CoA binding site [chemical binding]; other site 749927000786 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 749927000787 Cellulose binding domain; Region: CBM_2; pfam00553 749927000788 Glyco_18 domain; Region: Glyco_18; smart00636 749927000789 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 749927000790 active site 749927000791 Cellulose binding domain; Region: CBM_2; pfam00553 749927000792 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 749927000793 active site 749927000794 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927000795 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927000796 inhibitor-cofactor binding pocket; inhibition site 749927000797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927000798 catalytic residue [active] 749927000799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927000800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927000801 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 749927000802 putative dimerization interface [polypeptide binding]; other site 749927000803 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 749927000804 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 749927000805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927000806 binding surface 749927000807 TPR motif; other site 749927000808 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 749927000809 Probable pheophorbidase; Region: PLN02965; cl17657 749927000810 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927000811 3D domain; Region: 3D; cl01439 749927000812 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 749927000813 FMN binding site [chemical binding]; other site 749927000814 dimer interface [polypeptide binding]; other site 749927000815 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927000816 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927000817 active site 749927000818 catalytic tetrad [active] 749927000819 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927000820 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927000821 putative Zn2+ binding site [ion binding]; other site 749927000822 putative DNA binding site [nucleotide binding]; other site 749927000823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927000824 ATP binding site [chemical binding]; other site 749927000825 Mg2+ binding site [ion binding]; other site 749927000826 G-X-G motif; other site 749927000827 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 749927000828 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927000829 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 749927000830 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927000831 DNA binding residues [nucleotide binding] 749927000832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 749927000833 Transcription factor WhiB; Region: Whib; pfam02467 749927000834 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927000835 anti sigma factor interaction site; other site 749927000836 regulatory phosphorylation site [posttranslational modification]; other site 749927000837 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 749927000838 SnoaL-like domain; Region: SnoaL_4; pfam13577 749927000839 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927000840 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927000841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927000842 putative substrate translocation pore; other site 749927000843 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 749927000844 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927000845 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927000846 Walker A/P-loop; other site 749927000847 ATP binding site [chemical binding]; other site 749927000848 Q-loop/lid; other site 749927000849 ABC transporter signature motif; other site 749927000850 Walker B; other site 749927000851 D-loop; other site 749927000852 H-loop/switch region; other site 749927000853 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 749927000854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927000855 dimerization interface [polypeptide binding]; other site 749927000856 putative Zn2+ binding site [ion binding]; other site 749927000857 putative DNA binding site [nucleotide binding]; other site 749927000858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927000859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927000860 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927000861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927000862 NAD(P) binding site [chemical binding]; other site 749927000863 active site 749927000864 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 749927000865 active site 749927000866 catalytic triad [active] 749927000867 oxyanion hole [active] 749927000868 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927000869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927000870 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 749927000871 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 749927000872 NodB motif; other site 749927000873 active site 749927000874 catalytic site [active] 749927000875 metal binding site [ion binding]; metal-binding site 749927000876 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 749927000877 putative hydrophobic ligand binding site [chemical binding]; other site 749927000878 protein interface [polypeptide binding]; other site 749927000879 gate; other site 749927000880 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 749927000881 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 749927000882 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 749927000883 prephenate dehydrogenase; Validated; Region: PRK06545 749927000884 prephenate dehydrogenase; Validated; Region: PRK08507 749927000885 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 749927000886 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 749927000887 active site 749927000888 FMN binding site [chemical binding]; other site 749927000889 2,4-decadienoyl-CoA binding site; other site 749927000890 catalytic residue [active] 749927000891 4Fe-4S cluster binding site [ion binding]; other site 749927000892 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927000893 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927000894 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 749927000895 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 749927000896 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 749927000897 active site 749927000898 nucleophile elbow; other site 749927000899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927000900 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927000901 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927000902 putative Zn2+ binding site [ion binding]; other site 749927000903 putative DNA binding site [nucleotide binding]; other site 749927000904 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927000905 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927000906 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 749927000907 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927000908 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 749927000909 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 749927000910 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927000911 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927000912 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927000913 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927000914 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 749927000915 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 749927000916 tetramer interface [polypeptide binding]; other site 749927000917 active site 749927000918 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 749927000919 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927000920 CBD_II domain; Region: CBD_II; smart00637 749927000921 AAA domain; Region: AAA_33; pfam13671 749927000922 AAA domain; Region: AAA_18; pfam13238 749927000923 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 749927000924 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 749927000925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927000926 active site 749927000927 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927000928 Sporozoite P67 surface antigen; Region: Sporozoite_P67; pfam05642 749927000929 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927000930 catalytic core [active] 749927000931 Alginate lyase; Region: Alginate_lyase; pfam05426 749927000932 Homeodomain-like domain; Region: HTH_23; pfam13384 749927000933 Winged helix-turn helix; Region: HTH_29; pfam13551 749927000934 Homeodomain-like domain; Region: HTH_32; pfam13565 749927000935 DDE superfamily endonuclease; Region: DDE_3; cl19249 749927000936 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 749927000937 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 749927000938 Trypsin-like serine protease; Region: Tryp_SPc; smart00020 749927000939 cleavage site 749927000940 active site 749927000941 substrate binding sites [chemical binding]; other site 749927000942 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927000943 active site 749927000944 ATP binding site [chemical binding]; other site 749927000945 substrate binding site [chemical binding]; other site 749927000946 activation loop (A-loop); other site 749927000947 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 749927000948 active site 749927000949 zinc binding site [ion binding]; other site 749927000950 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 749927000951 active site 749927000952 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 749927000953 active site 749927000954 NAD binding site [chemical binding]; other site 749927000955 metal binding site [ion binding]; metal-binding site 749927000956 thiamine pyrophosphate protein; Validated; Region: PRK08199 749927000957 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749927000958 PYR/PP interface [polypeptide binding]; other site 749927000959 dimer interface [polypeptide binding]; other site 749927000960 TPP binding site [chemical binding]; other site 749927000961 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927000962 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 749927000963 TPP-binding site [chemical binding]; other site 749927000964 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 749927000965 DNA-binding site [nucleotide binding]; DNA binding site 749927000966 RNA-binding motif; other site 749927000967 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749927000968 metal-binding site [ion binding] 749927000969 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 749927000970 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 749927000971 TPP-binding site [chemical binding]; other site 749927000972 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 749927000973 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749927000974 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749927000975 substrate binding pocket [chemical binding]; other site 749927000976 membrane-bound complex binding site; other site 749927000977 hinge residues; other site 749927000978 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 749927000979 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927000980 active site 749927000981 ATP binding site [chemical binding]; other site 749927000982 substrate binding site [chemical binding]; other site 749927000983 activation loop (A-loop); other site 749927000984 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749927000985 active site 749927000986 Int/Topo IB signature motif; other site 749927000987 DNA binding site [nucleotide binding] 749927000988 Helix-turn-helix domain; Region: HTH_17; cl17695 749927000989 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 749927000990 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 749927000991 cofactor binding site; other site 749927000992 DNA binding site [nucleotide binding] 749927000993 substrate interaction site [chemical binding]; other site 749927000994 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 749927000995 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 749927000996 polymerase nucleotide-binding site; other site 749927000997 DNA-binding residues [nucleotide binding]; DNA binding site 749927000998 nucleotide binding site [chemical binding]; other site 749927000999 primase nucleotide-binding site [nucleotide binding]; other site 749927001000 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 749927001001 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 749927001002 dimer interface [polypeptide binding]; other site 749927001003 ssDNA binding site [nucleotide binding]; other site 749927001004 tetramer (dimer of dimers) interface [polypeptide binding]; other site 749927001005 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927001006 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 749927001007 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 749927001008 nudix motif; other site 749927001009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927001010 Coenzyme A binding pocket [chemical binding]; other site 749927001011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927001012 S-adenosylmethionine binding site [chemical binding]; other site 749927001013 YCII-related domain; Region: YCII; cl00999 749927001014 N-acetyltransferase; Region: Acetyltransf_2; cl00949 749927001015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927001016 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 749927001017 putative active site [active] 749927001018 heme pocket [chemical binding]; other site 749927001019 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927001020 putative active site [active] 749927001021 heme pocket [chemical binding]; other site 749927001022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927001023 putative active site [active] 749927001024 heme pocket [chemical binding]; other site 749927001025 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927001026 metal binding site [ion binding]; metal-binding site 749927001027 active site 749927001028 I-site; other site 749927001029 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 749927001030 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927001031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927001032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927001033 Sulfate transporter family; Region: Sulfate_transp; cl19250 749927001034 xanthine permease; Region: pbuX; TIGR03173 749927001035 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 749927001036 substrate binding site [chemical binding]; other site 749927001037 THF binding site; other site 749927001038 zinc-binding site [ion binding]; other site 749927001039 NIPSNAP; Region: NIPSNAP; pfam07978 749927001040 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927001041 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927001042 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927001043 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 749927001044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927001045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927001046 Reductase C-terminal; Region: Reductase_C; pfam14759 749927001047 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927001048 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927001049 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 749927001050 Clp amino terminal domain; Region: Clp_N; pfam02861 749927001051 Clp amino terminal domain; Region: Clp_N; pfam02861 749927001052 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 749927001053 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 749927001054 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 749927001055 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927001056 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927001057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927001058 non-specific DNA binding site [nucleotide binding]; other site 749927001059 salt bridge; other site 749927001060 sequence-specific DNA binding site [nucleotide binding]; other site 749927001061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927001062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927001063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927001064 S-adenosylmethionine binding site [chemical binding]; other site 749927001065 Domain of unknown function (DUF397); Region: DUF397; pfam04149 749927001066 YtkA-like; Region: YtkA; pfam13115 749927001067 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927001068 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927001069 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 749927001070 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 749927001071 CGNR zinc finger; Region: zf-CGNR; pfam11706 749927001072 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 749927001073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927001074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927001075 amidase; Provisional; Region: PRK06061 749927001076 RibD C-terminal domain; Region: RibD_C; cl17279 749927001077 D-cysteine desulfhydrase; Validated; Region: PRK03910 749927001078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927001079 catalytic residue [active] 749927001080 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 749927001081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 749927001082 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; cl17893 749927001083 Clp amino terminal domain; Region: Clp_N; pfam02861 749927001084 Clp amino terminal domain; Region: Clp_N; pfam02861 749927001085 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 749927001086 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 749927001087 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 749927001088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927001089 DNA-binding site [nucleotide binding]; DNA binding site 749927001090 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927001091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927001092 homodimer interface [polypeptide binding]; other site 749927001093 catalytic residue [active] 749927001094 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 749927001095 aminotransferase; Validated; Region: PRK07777 749927001096 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927001097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927001098 homodimer interface [polypeptide binding]; other site 749927001099 catalytic residue [active] 749927001100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 749927001101 Protein of unknown function (DUF445); Region: DUF445; pfam04286 749927001102 CGNR zinc finger; Region: zf-CGNR; pfam11706 749927001103 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927001104 active site 749927001105 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 749927001106 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 749927001107 AAA domain; Region: AAA_33; pfam13671 749927001108 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 749927001109 active site 749927001110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927001111 S-adenosylmethionine binding site [chemical binding]; other site 749927001112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927001113 non-specific DNA binding site [nucleotide binding]; other site 749927001114 salt bridge; other site 749927001115 sequence-specific DNA binding site [nucleotide binding]; other site 749927001116 CT11-RanBPM; Region: CRA; smart00757 749927001117 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 749927001118 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 749927001119 putative deacylase active site [active] 749927001120 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 749927001121 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 749927001122 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 749927001123 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 749927001124 active sites [active] 749927001125 tetramer interface [polypeptide binding]; other site 749927001126 Cadmium resistance transporter; Region: Cad; cl19409 749927001127 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 749927001128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927001129 dimer interface [polypeptide binding]; other site 749927001130 conserved gate region; other site 749927001131 putative PBP binding loops; other site 749927001132 ABC-ATPase subunit interface; other site 749927001133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927001134 dimer interface [polypeptide binding]; other site 749927001135 conserved gate region; other site 749927001136 putative PBP binding loops; other site 749927001137 ABC-ATPase subunit interface; other site 749927001138 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927001139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927001140 S-adenosylmethionine binding site [chemical binding]; other site 749927001141 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927001142 putative DNA binding site [nucleotide binding]; other site 749927001143 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927001144 putative Zn2+ binding site [ion binding]; other site 749927001145 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 749927001146 hydrophobic ligand binding site; other site 749927001147 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 749927001148 Prostaglandin dehydrogenases; Region: PGDH; cd05288 749927001149 NAD(P) binding site [chemical binding]; other site 749927001150 substrate binding site [chemical binding]; other site 749927001151 dimer interface [polypeptide binding]; other site 749927001152 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 749927001153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927001154 motif II; other site 749927001155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927001156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927001157 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 749927001158 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 749927001159 putative NAD(P) binding site [chemical binding]; other site 749927001160 putative substrate binding site [chemical binding]; other site 749927001161 catalytic Zn binding site [ion binding]; other site 749927001162 structural Zn binding site [ion binding]; other site 749927001163 dimer interface [polypeptide binding]; other site 749927001164 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 749927001165 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 749927001166 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 749927001167 putative active site [active] 749927001168 putative substrate binding site [chemical binding]; other site 749927001169 putative cosubstrate binding site; other site 749927001170 catalytic site [active] 749927001171 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927001172 DinB superfamily; Region: DinB_2; cl19195 749927001173 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 749927001174 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 749927001175 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 749927001176 FAD binding domain; Region: FAD_binding_4; pfam01565 749927001177 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 749927001178 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 749927001179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 749927001180 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 749927001181 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 749927001182 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927001183 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927001184 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 749927001185 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 749927001186 putative ADP-binding pocket [chemical binding]; other site 749927001187 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 749927001188 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 749927001189 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927001190 catalytic core [active] 749927001191 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927001192 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 749927001193 dimerization interface [polypeptide binding]; other site 749927001194 DNA binding residues [nucleotide binding] 749927001195 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927001196 active site 749927001197 catalytic tetrad [active] 749927001198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927001199 dimer interface [polypeptide binding]; other site 749927001200 phosphorylation site [posttranslational modification] 749927001201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927001202 ATP binding site [chemical binding]; other site 749927001203 Mg2+ binding site [ion binding]; other site 749927001204 G-X-G motif; other site 749927001205 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927001206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927001207 active site 749927001208 phosphorylation site [posttranslational modification] 749927001209 intermolecular recognition site; other site 749927001210 dimerization interface [polypeptide binding]; other site 749927001211 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927001212 DNA binding site [nucleotide binding] 749927001213 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 749927001214 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 749927001215 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 749927001216 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927001217 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 749927001218 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 749927001219 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 749927001220 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 749927001221 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 749927001222 DNA binding domain, excisionase family; Region: excise; TIGR01764 749927001223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927001224 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927001225 NAD(P) binding site [chemical binding]; other site 749927001226 active site 749927001227 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 749927001228 putative acyl-acceptor binding pocket; other site 749927001229 Putative sensor; Region: Sensor; pfam13796 749927001230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927001231 Histidine kinase; Region: HisKA_3; pfam07730 749927001232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927001233 ATP binding site [chemical binding]; other site 749927001234 Mg2+ binding site [ion binding]; other site 749927001235 G-X-G motif; other site 749927001236 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927001237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927001238 active site 749927001239 phosphorylation site [posttranslational modification] 749927001240 intermolecular recognition site; other site 749927001241 dimerization interface [polypeptide binding]; other site 749927001242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927001243 DNA binding residues [nucleotide binding] 749927001244 CAAX protease self-immunity; Region: Abi; pfam02517 749927001245 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 749927001246 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 749927001247 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 749927001248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927001249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927001250 DNA binding residues [nucleotide binding] 749927001251 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927001252 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927001253 acyl-activating enzyme (AAE) consensus motif; other site 749927001254 AMP binding site [chemical binding]; other site 749927001255 active site 749927001256 CoA binding site [chemical binding]; other site 749927001257 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 749927001258 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 749927001259 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 749927001260 Moco binding site; other site 749927001261 metal coordination site [ion binding]; other site 749927001262 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 749927001263 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 749927001264 CoA binding domain; Region: CoA_binding; pfam02629 749927001265 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 749927001266 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 749927001267 tRNA; other site 749927001268 putative tRNA binding site [nucleotide binding]; other site 749927001269 putative NADP binding site [chemical binding]; other site 749927001270 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 749927001271 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 749927001272 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 749927001273 domain interfaces; other site 749927001274 active site 749927001275 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 749927001276 active site 749927001277 homodimer interface [polypeptide binding]; other site 749927001278 SAM binding site [chemical binding]; other site 749927001279 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 749927001280 active site 749927001281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927001282 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927001283 NAD(P) binding site [chemical binding]; other site 749927001284 active site 749927001285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 749927001286 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 749927001287 dimer interface [polypeptide binding]; other site 749927001288 active site 749927001289 Schiff base residues; other site 749927001290 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 749927001291 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 749927001292 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 749927001293 HlyD family secretion protein; Region: HlyD_3; pfam13437 749927001294 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 749927001295 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 749927001296 Walker A/P-loop; other site 749927001297 ATP binding site [chemical binding]; other site 749927001298 Q-loop/lid; other site 749927001299 ABC transporter signature motif; other site 749927001300 Walker B; other site 749927001301 D-loop; other site 749927001302 H-loop/switch region; other site 749927001303 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 749927001304 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 749927001305 FtsX-like permease family; Region: FtsX; pfam02687 749927001306 TspO/MBR family; Region: TspO_MBR; pfam03073 749927001307 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 749927001308 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927001309 inhibitor-cofactor binding pocket; inhibition site 749927001310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927001311 catalytic residue [active] 749927001312 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927001313 catalytic core [active] 749927001314 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 749927001315 catalytic residues [active] 749927001316 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 749927001317 ResB-like family; Region: ResB; pfam05140 749927001318 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 749927001319 Transcription factor IIA, alpha/beta subunit; Region: TFIIA; pfam03153 749927001320 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 749927001321 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927001322 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 749927001323 DNA binding residues [nucleotide binding] 749927001324 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927001325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927001326 putative DNA binding site [nucleotide binding]; other site 749927001327 putative Zn2+ binding site [ion binding]; other site 749927001328 AsnC family; Region: AsnC_trans_reg; pfam01037 749927001329 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 749927001330 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927001331 catalytic residue [active] 749927001332 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 749927001333 putative active site [active] 749927001334 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 749927001335 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927001336 acyl-activating enzyme (AAE) consensus motif; other site 749927001337 AMP binding site [chemical binding]; other site 749927001338 active site 749927001339 CoA binding site [chemical binding]; other site 749927001340 Dihydroxynaphthoic acid synthase [Coenzyme metabolism]; Region: MenB; COG0447 749927001341 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927001342 substrate binding site [chemical binding]; other site 749927001343 oxyanion hole (OAH) forming residues; other site 749927001344 trimer interface [polypeptide binding]; other site 749927001345 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 749927001346 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 749927001347 dimer interface [polypeptide binding]; other site 749927001348 tetramer interface [polypeptide binding]; other site 749927001349 PYR/PP interface [polypeptide binding]; other site 749927001350 TPP binding site [chemical binding]; other site 749927001351 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 749927001352 TPP-binding site; other site 749927001353 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 749927001354 Zn binding site [ion binding]; other site 749927001355 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 749927001356 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 749927001357 active site 749927001358 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927001359 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 749927001360 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927001361 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 749927001362 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927001363 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927001364 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 749927001365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927001366 S-adenosylmethionine binding site [chemical binding]; other site 749927001367 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 749927001368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927001369 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 749927001370 NADH dehydrogenase subunit B; Validated; Region: PRK06411 749927001371 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 749927001372 NADH dehydrogenase subunit D; Validated; Region: PRK06075 749927001373 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 749927001374 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 749927001375 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 749927001376 putative dimer interface [polypeptide binding]; other site 749927001377 [2Fe-2S] cluster binding site [ion binding]; other site 749927001378 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 749927001379 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 749927001380 SLBB domain; Region: SLBB; pfam10531 749927001381 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 749927001382 NADH dehydrogenase subunit G; Validated; Region: PRK07860 749927001383 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927001384 catalytic loop [active] 749927001385 iron binding site [ion binding]; other site 749927001386 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 749927001387 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749927001388 molybdopterin cofactor binding site; other site 749927001389 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 749927001390 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 749927001391 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 749927001392 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 749927001393 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 749927001394 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 749927001395 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 749927001396 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 749927001397 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 749927001398 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 749927001399 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 749927001400 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 749927001401 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 749927001402 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 749927001403 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 749927001404 EspG family; Region: ESX-1_EspG; pfam14011 749927001405 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 749927001406 substrate binding pocket [chemical binding]; other site 749927001407 chain length determination region; other site 749927001408 substrate-Mg2+ binding site; other site 749927001409 catalytic residues [active] 749927001410 aspartate-rich region 1; other site 749927001411 active site lid residues [active] 749927001412 aspartate-rich region 2; other site 749927001413 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 749927001414 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 749927001415 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 749927001416 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 749927001417 TPP-binding site [chemical binding]; other site 749927001418 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 749927001419 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 749927001420 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 749927001421 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 749927001422 dimer interface [polypeptide binding]; other site 749927001423 PYR/PP interface [polypeptide binding]; other site 749927001424 TPP binding site [chemical binding]; other site 749927001425 substrate binding site [chemical binding]; other site 749927001426 enoyl-CoA hydratase; Provisional; Region: PRK05870 749927001427 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927001428 substrate binding site [chemical binding]; other site 749927001429 trimer interface [polypeptide binding]; other site 749927001430 oxyanion hole (OAH) forming residues; other site 749927001431 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927001432 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 749927001433 Amidinotransferase; Region: Amidinotransf; cl19186 749927001434 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 749927001435 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 749927001436 putative active site [active] 749927001437 putative metal binding site [ion binding]; other site 749927001438 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 749927001439 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 749927001440 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 749927001441 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 749927001442 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 749927001443 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 749927001444 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927001445 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 749927001446 Chain length determinant protein; Region: Wzz; pfam02706 749927001447 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 749927001448 Chain length determinant protein; Region: Wzz; pfam02706 749927001449 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 749927001450 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 749927001451 active site 749927001452 dimer interface [polypeptide binding]; other site 749927001453 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 749927001454 Ligand Binding Site [chemical binding]; other site 749927001455 Molecular Tunnel; other site 749927001456 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927001457 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 749927001458 putative NAD(P) binding site [chemical binding]; other site 749927001459 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927001460 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927001461 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927001462 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 749927001463 Right handed beta helix region; Region: Beta_helix; pfam13229 749927001464 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 749927001465 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927001466 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927001467 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 749927001468 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 749927001469 active site 749927001470 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927001471 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 749927001472 Right handed beta helix region; Region: Beta_helix; pfam13229 749927001473 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927001474 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 749927001475 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927001476 catalytic residue [active] 749927001477 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 749927001478 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 749927001479 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 749927001480 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 749927001481 active site 749927001482 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 749927001483 M28 Zn-Peptidases; Region: M28_like_3; cd05644 749927001484 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 749927001485 active site 749927001486 metal binding site [ion binding]; metal-binding site 749927001487 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927001488 extended (e) SDRs; Region: SDR_e; cd08946 749927001489 NAD(P) binding site [chemical binding]; other site 749927001490 active site 749927001491 substrate binding site [chemical binding]; other site 749927001492 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 749927001493 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 749927001494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927001495 active site 749927001496 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 749927001497 Methyltransferase domain; Region: Methyltransf_23; pfam13489 749927001498 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 749927001499 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 749927001500 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 749927001501 Uncharacterized conserved protein [Function unknown]; Region: COG3391 749927001502 heat shock protein HtpX; Provisional; Region: PRK03072 749927001503 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927001504 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 749927001505 active site 749927001506 non-prolyl cis peptide bond; other site 749927001507 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 749927001508 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 749927001509 substrate binding site; other site 749927001510 tetramer interface; other site 749927001511 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 749927001512 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 749927001513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927001514 S-adenosylmethionine binding site [chemical binding]; other site 749927001515 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 749927001516 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 749927001517 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927001518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927001519 Walker A motif; other site 749927001520 ATP binding site [chemical binding]; other site 749927001521 Walker B motif; other site 749927001522 arginine finger; other site 749927001523 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 749927001524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927001525 S-adenosylmethionine binding site [chemical binding]; other site 749927001526 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927001527 Coenzyme A binding pocket [chemical binding]; other site 749927001528 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 749927001529 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927001530 metal binding site [ion binding]; metal-binding site 749927001531 active site 749927001532 I-site; other site 749927001533 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 749927001534 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 749927001535 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 749927001536 active site 749927001537 catalytic site [active] 749927001538 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 749927001539 active site 749927001540 catalytic site [active] 749927001541 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 749927001542 active site 749927001543 catalytic triad [active] 749927001544 oxyanion hole [active] 749927001545 Predicted transcriptional regulators [Transcription]; Region: COG1725 749927001546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927001547 DNA-binding site [nucleotide binding]; DNA binding site 749927001548 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927001549 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 749927001550 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 749927001551 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 749927001552 putative homodimer interface [polypeptide binding]; other site 749927001553 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 749927001554 heterodimer interface [polypeptide binding]; other site 749927001555 homodimer interface [polypeptide binding]; other site 749927001556 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 749927001557 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 749927001558 putative thiostrepton binding site; other site 749927001559 23S rRNA interface [nucleotide binding]; other site 749927001560 L7/L12 interface [polypeptide binding]; other site 749927001561 L25 interface [polypeptide binding]; other site 749927001562 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 749927001563 mRNA/rRNA interface [nucleotide binding]; other site 749927001564 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927001565 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927001566 septum formation inhibitor; Provisional; Region: minC; PRK00030 749927001567 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 749927001568 23S rRNA interface [nucleotide binding]; other site 749927001569 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 749927001570 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 749927001571 core dimer interface [polypeptide binding]; other site 749927001572 peripheral dimer interface [polypeptide binding]; other site 749927001573 L10 interface [polypeptide binding]; other site 749927001574 L11 interface [polypeptide binding]; other site 749927001575 putative EF-Tu interaction site [polypeptide binding]; other site 749927001576 putative EF-G interaction site [polypeptide binding]; other site 749927001577 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 749927001578 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 749927001579 Walker A/P-loop; other site 749927001580 ATP binding site [chemical binding]; other site 749927001581 Q-loop/lid; other site 749927001582 ABC transporter signature motif; other site 749927001583 Walker B; other site 749927001584 D-loop; other site 749927001585 H-loop/switch region; other site 749927001586 Permease; Region: Permease; pfam02405 749927001587 Permease; Region: Permease; pfam02405 749927001588 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927001589 mce related protein; Region: MCE; pfam02470 749927001590 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927001591 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927001592 mce related protein; Region: MCE; pfam02470 749927001593 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927001594 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927001595 mce related protein; Region: MCE; pfam02470 749927001596 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927001597 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 749927001598 linker region; other site 749927001599 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927001600 mce related protein; Region: MCE; pfam02470 749927001601 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927001602 mce related protein; Region: MCE; pfam02470 749927001603 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927001604 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927001605 mce related protein; Region: MCE; pfam02470 749927001606 dihydrolipoamide succinyltransferase; Provisional; Region: PTZ00144 749927001607 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927001608 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927001609 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927001610 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927001611 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 749927001612 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927001613 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927001614 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927001615 acyl-activating enzyme (AAE) consensus motif; other site 749927001616 AMP binding site [chemical binding]; other site 749927001617 active site 749927001618 CoA binding site [chemical binding]; other site 749927001619 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927001620 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927001621 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927001622 active site 749927001623 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927001624 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 749927001625 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 749927001626 short chain dehydrogenase; Region: adh_short; pfam00106 749927001627 putative NADP binding site [chemical binding]; other site 749927001628 active site 749927001629 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927001630 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927001631 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927001632 active site 749927001633 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927001634 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927001635 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927001636 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 749927001637 active site 749927001638 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927001639 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 749927001640 short chain dehydrogenase; Region: adh_short; pfam00106 749927001641 NADP binding site [chemical binding]; other site 749927001642 active site 749927001643 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927001644 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927001645 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927001646 active site 749927001647 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927001648 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 749927001649 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 749927001650 putative NADP binding site [chemical binding]; other site 749927001651 short chain dehydrogenase; Region: adh_short; pfam00106 749927001652 active site 749927001653 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927001654 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927001655 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927001656 active site 749927001657 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927001658 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 749927001659 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 749927001660 short chain dehydrogenase; Region: adh_short; pfam00106 749927001661 putative NADP binding site [chemical binding]; other site 749927001662 active site 749927001663 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927001664 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927001665 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927001666 active site 749927001667 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927001668 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 749927001669 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 749927001670 short chain dehydrogenase; Region: adh_short; pfam00106 749927001671 putative NADP binding site [chemical binding]; other site 749927001672 active site 749927001673 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927001674 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927001675 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927001676 active site 749927001677 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927001678 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 749927001679 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 749927001680 short chain dehydrogenase; Region: adh_short; pfam00106 749927001681 putative NADP binding site [chemical binding]; other site 749927001682 active site 749927001683 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927001684 Erythronolide synthase docking; Region: Docking; pfam08990 749927001685 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927001686 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927001687 active site 749927001688 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927001689 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 749927001690 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 749927001691 short chain dehydrogenase; Region: adh_short; pfam00106 749927001692 putative NADP binding site [chemical binding]; other site 749927001693 active site 749927001694 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927001695 Erythronolide synthase docking; Region: Docking; pfam08990 749927001696 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927001697 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927001698 active site 749927001699 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927001700 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 749927001701 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 749927001702 short chain dehydrogenase; Region: adh_short; pfam00106 749927001703 putative NADP binding site [chemical binding]; other site 749927001704 active site 749927001705 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927001706 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927001707 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927001708 active site 749927001709 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927001710 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 749927001711 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 749927001712 putative NADP binding site [chemical binding]; other site 749927001713 short chain dehydrogenase; Region: adh_short; pfam00106 749927001714 active site 749927001715 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927001716 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 749927001717 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 749927001718 dimer interface [polypeptide binding]; other site 749927001719 active site 749927001720 metal binding site [ion binding]; metal-binding site 749927001721 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 749927001722 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 749927001723 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 749927001724 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 749927001725 shikimate binding site; other site 749927001726 NAD(P) binding site [chemical binding]; other site 749927001727 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 749927001728 inhibitor-cofactor binding pocket; inhibition site 749927001729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927001730 catalytic residue [active] 749927001731 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927001732 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927001733 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927001734 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 749927001735 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 749927001736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927001737 motif II; other site 749927001738 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927001739 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927001740 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927001741 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 749927001742 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927001743 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927001744 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 749927001745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927001746 putative substrate translocation pore; other site 749927001747 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 749927001748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927001749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927001750 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927001751 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 749927001752 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 749927001753 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927001754 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927001755 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 749927001756 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 749927001757 inhibitor-cofactor binding pocket; inhibition site 749927001758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927001759 catalytic residue [active] 749927001760 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927001761 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927001762 homodimer interface [polypeptide binding]; other site 749927001763 active site 749927001764 TDP-binding site; other site 749927001765 acceptor substrate-binding pocket; other site 749927001766 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 749927001767 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927001768 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927001769 inhibitor-cofactor binding pocket; inhibition site 749927001770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927001771 catalytic residue [active] 749927001772 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927001773 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927001774 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927001775 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927001776 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927001777 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 749927001778 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 749927001779 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 749927001780 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 749927001781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927001782 acyltransferase PapA5; Provisional; Region: PRK09294 749927001783 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 749927001784 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927001785 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927001786 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749927001787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927001788 S-adenosylmethionine binding site [chemical binding]; other site 749927001789 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 749927001790 TPP-binding site [chemical binding]; other site 749927001791 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 749927001792 PYR/PP interface [polypeptide binding]; other site 749927001793 dimer interface [polypeptide binding]; other site 749927001794 TPP binding site [chemical binding]; other site 749927001795 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927001796 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 749927001797 trimer interface [polypeptide binding]; other site 749927001798 active site 749927001799 dimer interface [polypeptide binding]; other site 749927001800 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927001801 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927001802 DNA binding residues [nucleotide binding] 749927001803 dimerization interface [polypeptide binding]; other site 749927001804 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 749927001805 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 749927001806 RPB12 interaction site [polypeptide binding]; other site 749927001807 RPB1 interaction site [polypeptide binding]; other site 749927001808 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 749927001809 RPB10 interaction site [polypeptide binding]; other site 749927001810 RPB11 interaction site [polypeptide binding]; other site 749927001811 RPB3 interaction site [polypeptide binding]; other site 749927001812 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 749927001813 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 749927001814 beta and beta' interface [polypeptide binding]; other site 749927001815 beta' and sigma factor interface [polypeptide binding]; other site 749927001816 Zn-binding [ion binding]; other site 749927001817 active site region [active] 749927001818 catalytic site [active] 749927001819 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 749927001820 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 749927001821 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 749927001822 G-loop; other site 749927001823 DNA binding site [nucleotide binding] 749927001824 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 749927001825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927001826 putative DNA binding site [nucleotide binding]; other site 749927001827 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927001828 putative Zn2+ binding site [ion binding]; other site 749927001829 AsnC family; Region: AsnC_trans_reg; pfam01037 749927001830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927001831 Double zinc ribbon; Region: DZR; pfam12773 749927001832 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 749927001833 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 749927001834 ligand binding site [chemical binding]; other site 749927001835 flexible hinge region; other site 749927001836 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 749927001837 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 749927001838 IncA protein; Region: IncA; pfam04156 749927001839 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 749927001840 S17 interaction site [polypeptide binding]; other site 749927001841 S8 interaction site; other site 749927001842 16S rRNA interaction site [nucleotide binding]; other site 749927001843 streptomycin interaction site [chemical binding]; other site 749927001844 23S rRNA interaction site [nucleotide binding]; other site 749927001845 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 749927001846 30S ribosomal protein S7; Validated; Region: PRK05302 749927001847 elongation factor G; Reviewed; Region: PRK00007 749927001848 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 749927001849 G1 box; other site 749927001850 putative GEF interaction site [polypeptide binding]; other site 749927001851 GTP/Mg2+ binding site [chemical binding]; other site 749927001852 Switch I region; other site 749927001853 G2 box; other site 749927001854 G3 box; other site 749927001855 Switch II region; other site 749927001856 G4 box; other site 749927001857 G5 box; other site 749927001858 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 749927001859 Elongation Factor G, domain II; Region: EFG_II; pfam14492 749927001860 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 749927001861 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 749927001862 elongation factor Tu; Reviewed; Region: PRK00049 749927001863 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 749927001864 G1 box; other site 749927001865 GEF interaction site [polypeptide binding]; other site 749927001866 GTP/Mg2+ binding site [chemical binding]; other site 749927001867 Switch I region; other site 749927001868 G2 box; other site 749927001869 G3 box; other site 749927001870 Switch II region; other site 749927001871 G4 box; other site 749927001872 G5 box; other site 749927001873 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 749927001874 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 749927001875 Antibiotic Binding Site [chemical binding]; other site 749927001876 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 749927001877 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 749927001878 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 749927001879 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 749927001880 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 749927001881 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 749927001882 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 749927001883 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 749927001884 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 749927001885 putative translocon binding site; other site 749927001886 protein-rRNA interface [nucleotide binding]; other site 749927001887 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 749927001888 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 749927001889 G-X-X-G motif; other site 749927001890 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 749927001891 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 749927001892 23S rRNA interface [nucleotide binding]; other site 749927001893 5S rRNA interface [nucleotide binding]; other site 749927001894 putative antibiotic binding site [chemical binding]; other site 749927001895 L25 interface [polypeptide binding]; other site 749927001896 L27 interface [polypeptide binding]; other site 749927001897 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 749927001898 23S rRNA interface [nucleotide binding]; other site 749927001899 putative translocon interaction site; other site 749927001900 signal recognition particle (SRP54) interaction site; other site 749927001901 L23 interface [polypeptide binding]; other site 749927001902 trigger factor interaction site; other site 749927001903 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 749927001904 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 749927001905 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 749927001906 RNA binding site [nucleotide binding]; other site 749927001907 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 749927001908 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 749927001909 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 749927001910 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 749927001911 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 749927001912 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 749927001913 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 749927001914 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 749927001915 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 749927001916 5S rRNA interface [nucleotide binding]; other site 749927001917 L27 interface [polypeptide binding]; other site 749927001918 23S rRNA interface [nucleotide binding]; other site 749927001919 L5 interface [polypeptide binding]; other site 749927001920 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 749927001921 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 749927001922 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 749927001923 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 749927001924 23S rRNA binding site [nucleotide binding]; other site 749927001925 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 749927001926 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 749927001927 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 749927001928 SecY translocase; Region: SecY; pfam00344 749927001929 adenylate kinase; Reviewed; Region: adk; PRK00279 749927001930 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 749927001931 AMP-binding site [chemical binding]; other site 749927001932 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 749927001933 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 749927001934 active site 749927001935 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 749927001936 rRNA binding site [nucleotide binding]; other site 749927001937 predicted 30S ribosome binding site; other site 749927001938 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 749927001939 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 749927001940 30S ribosomal protein S11; Validated; Region: PRK05309 749927001941 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 749927001942 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 749927001943 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749927001944 RNA binding surface [nucleotide binding]; other site 749927001945 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 749927001946 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 749927001947 alphaNTD homodimer interface [polypeptide binding]; other site 749927001948 alphaNTD - beta interaction site [polypeptide binding]; other site 749927001949 alphaNTD - beta' interaction site [polypeptide binding]; other site 749927001950 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 749927001951 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 749927001952 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 749927001953 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 749927001954 active site 749927001955 dimerization interface 3.5A [polypeptide binding]; other site 749927001956 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 749927001957 Protein of unknown function (DUF690); Region: DUF690; cl04939 749927001958 ATP-NAD kinase; Region: NAD_kinase; cl01255 749927001959 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 749927001960 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 749927001961 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927001962 active site 749927001963 catalytic residues [active] 749927001964 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 749927001965 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 749927001966 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927001967 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 749927001968 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927001969 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927001970 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 749927001971 nucleotide binding site [chemical binding]; other site 749927001972 putative NEF/HSP70 interaction site [polypeptide binding]; other site 749927001973 SBD interface [polypeptide binding]; other site 749927001974 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 749927001975 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 749927001976 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 749927001977 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 749927001978 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 749927001979 23S rRNA interface [nucleotide binding]; other site 749927001980 L3 interface [polypeptide binding]; other site 749927001981 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 749927001982 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 749927001983 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 749927001984 active site 749927001985 substrate binding site [chemical binding]; other site 749927001986 metal binding site [ion binding]; metal-binding site 749927001987 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927001988 acyl-CoA synthetase; Validated; Region: PRK05850 749927001989 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 749927001990 acyl-activating enzyme (AAE) consensus motif; other site 749927001991 active site 749927001992 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927001993 Proteins of 100 residues with WXG; Region: WXG100; cl02005 749927001994 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927001995 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927001996 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 749927001997 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 749927001998 glutaminase active site [active] 749927001999 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 749927002000 dimer interface [polypeptide binding]; other site 749927002001 active site 749927002002 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 749927002003 dimer interface [polypeptide binding]; other site 749927002004 active site 749927002005 Uncharacterized conserved protein [Function unknown]; Region: COG0062 749927002006 putative carbohydrate kinase; Provisional; Region: PRK10565 749927002007 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 749927002008 putative substrate binding site [chemical binding]; other site 749927002009 putative ATP binding site [chemical binding]; other site 749927002010 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 749927002011 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 749927002012 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 749927002013 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927002014 D-xylulose kinase; Region: XylB; TIGR01312 749927002015 nucleotide binding site [chemical binding]; other site 749927002016 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 749927002017 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 749927002018 Walker A/P-loop; other site 749927002019 ATP binding site [chemical binding]; other site 749927002020 Q-loop/lid; other site 749927002021 ABC transporter signature motif; other site 749927002022 Walker B; other site 749927002023 D-loop; other site 749927002024 H-loop/switch region; other site 749927002025 TOBE domain; Region: TOBE_2; pfam08402 749927002026 alanine racemase; Reviewed; Region: alr; PRK00053 749927002027 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 749927002028 active site 749927002029 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749927002030 dimer interface [polypeptide binding]; other site 749927002031 substrate binding site [chemical binding]; other site 749927002032 catalytic residues [active] 749927002033 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927002034 Probable pheophorbidase; Region: PLN02965; cl17657 749927002035 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927002036 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927002037 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 749927002038 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 749927002039 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 749927002040 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 749927002041 acyl-CoA synthetase; Validated; Region: PRK07787 749927002042 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 749927002043 acyl-activating enzyme (AAE) consensus motif; other site 749927002044 active site 749927002045 AMP binding site [chemical binding]; other site 749927002046 CoA binding site [chemical binding]; other site 749927002047 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 749927002048 Glycoprotease family; Region: Peptidase_M22; pfam00814 749927002049 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 749927002050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927002051 Coenzyme A binding pocket [chemical binding]; other site 749927002052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927002053 UGMP family protein; Validated; Region: PRK09604 749927002054 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 749927002055 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 749927002056 active site 749927002057 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 749927002058 homodimer interface [polypeptide binding]; other site 749927002059 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 749927002060 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 749927002061 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927002062 active site 749927002063 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 749927002064 amidase catalytic site [active] 749927002065 Zn binding residues [ion binding]; other site 749927002066 substrate binding site [chemical binding]; other site 749927002067 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749927002068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927002069 S-adenosylmethionine binding site [chemical binding]; other site 749927002070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927002071 dimerization interface [polypeptide binding]; other site 749927002072 putative DNA binding site [nucleotide binding]; other site 749927002073 putative Zn2+ binding site [ion binding]; other site 749927002074 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 749927002075 active site 749927002076 arsenical-resistance protein; Region: acr3; TIGR00832 749927002077 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927002078 dimerization interface [polypeptide binding]; other site 749927002079 putative DNA binding site [nucleotide binding]; other site 749927002080 putative Zn2+ binding site [ion binding]; other site 749927002081 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 749927002082 putative metal binding site [ion binding]; other site 749927002083 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 749927002084 oligomerisation interface [polypeptide binding]; other site 749927002085 mobile loop; other site 749927002086 roof hairpin; other site 749927002087 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 749927002088 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 749927002089 ring oligomerisation interface [polypeptide binding]; other site 749927002090 ATP/Mg binding site [chemical binding]; other site 749927002091 stacking interactions; other site 749927002092 hinge regions; other site 749927002093 Transcription factor WhiB; Region: Whib; pfam02467 749927002094 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927002095 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927002096 DNA binding residues [nucleotide binding] 749927002097 B12 binding domain; Region: B12-binding_2; pfam02607 749927002098 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927002099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927002100 active site 749927002101 phosphorylation site [posttranslational modification] 749927002102 intermolecular recognition site; other site 749927002103 dimerization interface [polypeptide binding]; other site 749927002104 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927002105 DNA binding residues [nucleotide binding] 749927002106 dimerization interface [polypeptide binding]; other site 749927002107 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 749927002108 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927002109 DNA binding residues [nucleotide binding] 749927002110 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 749927002111 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 749927002112 active site 749927002113 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 749927002114 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 749927002115 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 749927002116 phosphate binding site [ion binding]; other site 749927002117 Domain of unknown function (DUF397); Region: DUF397; pfam04149 749927002118 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 749927002119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927002120 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 749927002121 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 749927002122 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 749927002123 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927002124 FAD binding domain; Region: FAD_binding_4; pfam01565 749927002125 Berberine and berberine like; Region: BBE; pfam08031 749927002126 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927002127 NAD(P) binding site [chemical binding]; other site 749927002128 catalytic residues [active] 749927002129 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 749927002130 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927002131 catalytic Zn binding site [ion binding]; other site 749927002132 NAD(P) binding site [chemical binding]; other site 749927002133 structural Zn binding site [ion binding]; other site 749927002134 Rhomboid family; Region: Rhomboid; cl11446 749927002135 DinB superfamily; Region: DinB_2; pfam12867 749927002136 GMP synthase; Reviewed; Region: guaA; PRK00074 749927002137 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 749927002138 AMP/PPi binding site [chemical binding]; other site 749927002139 candidate oxyanion hole; other site 749927002140 catalytic triad [active] 749927002141 potential glutamine specificity residues [chemical binding]; other site 749927002142 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 749927002143 ATP Binding subdomain [chemical binding]; other site 749927002144 Ligand Binding sites [chemical binding]; other site 749927002145 Dimerization subdomain; other site 749927002146 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 749927002147 PspC domain; Region: PspC; pfam04024 749927002148 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753 749927002149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927002150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927002151 PspC domain; Region: PspC; pfam04024 749927002152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927002153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927002154 ATP binding site [chemical binding]; other site 749927002155 Mg2+ binding site [ion binding]; other site 749927002156 G-X-G motif; other site 749927002157 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927002158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927002159 active site 749927002160 phosphorylation site [posttranslational modification] 749927002161 intermolecular recognition site; other site 749927002162 dimerization interface [polypeptide binding]; other site 749927002163 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927002164 DNA binding residues [nucleotide binding] 749927002165 dimerization interface [polypeptide binding]; other site 749927002166 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 749927002167 EamA-like transporter family; Region: EamA; pfam00892 749927002168 EamA-like transporter family; Region: EamA; pfam00892 749927002169 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927002170 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927002171 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 749927002172 putative dimerization interface [polypeptide binding]; other site 749927002173 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927002174 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927002175 active site 749927002176 ATP binding site [chemical binding]; other site 749927002177 substrate binding site [chemical binding]; other site 749927002178 activation loop (A-loop); other site 749927002179 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927002180 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927002181 active site 749927002182 ATP binding site [chemical binding]; other site 749927002183 substrate binding site [chemical binding]; other site 749927002184 activation loop (A-loop); other site 749927002185 large tegument protein UL36; Provisional; Region: PHA03247 749927002186 Chorismate mutase type II; Region: CM_2; cl00693 749927002187 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 749927002188 2TM domain; Region: 2TM; pfam13239 749927002189 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 749927002190 Part of AAA domain; Region: AAA_19; pfam13245 749927002191 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 749927002192 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 749927002193 Peptidase family M23; Region: Peptidase_M23; pfam01551 749927002194 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 749927002195 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 749927002196 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 749927002197 CoA-ligase; Region: Ligase_CoA; pfam00549 749927002198 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 749927002199 CoA binding domain; Region: CoA_binding; smart00881 749927002200 CoA-ligase; Region: Ligase_CoA; pfam00549 749927002201 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 749927002202 active site 749927002203 substrate binding site [chemical binding]; other site 749927002204 cosubstrate binding site; other site 749927002205 catalytic site [active] 749927002206 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 749927002207 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 749927002208 purine monophosphate binding site [chemical binding]; other site 749927002209 dimer interface [polypeptide binding]; other site 749927002210 putative catalytic residues [active] 749927002211 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 749927002212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927002213 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 749927002214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927002215 Coenzyme A binding pocket [chemical binding]; other site 749927002216 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 749927002217 Zn2+ binding site [ion binding]; other site 749927002218 Mg2+ binding site [ion binding]; other site 749927002219 DNA Polymerase Y-family; Region: PolY_like; cd03468 749927002220 DNA binding site [nucleotide binding] 749927002221 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 749927002222 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 749927002223 active site 749927002224 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 749927002225 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 749927002226 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 749927002227 generic binding surface II; other site 749927002228 generic binding surface I; other site 749927002229 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 749927002230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927002231 S-adenosylmethionine binding site [chemical binding]; other site 749927002232 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 749927002233 Adenovirus EB1 55K protein / large t-antigen; Region: Adeno_E1B_55K; pfam01696 749927002234 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 749927002235 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 749927002236 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 749927002237 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 749927002238 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 749927002239 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 749927002240 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 749927002241 homodimer interface [polypeptide binding]; other site 749927002242 NADP binding site [chemical binding]; other site 749927002243 substrate binding site [chemical binding]; other site 749927002244 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 749927002245 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 749927002246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927002247 putative substrate translocation pore; other site 749927002248 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927002249 dimerization interface [polypeptide binding]; other site 749927002250 putative DNA binding site [nucleotide binding]; other site 749927002251 putative Zn2+ binding site [ion binding]; other site 749927002252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927002253 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927002254 putative substrate translocation pore; other site 749927002255 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 749927002256 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 749927002257 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 749927002258 minor groove reading motif; other site 749927002259 helix-hairpin-helix signature motif; other site 749927002260 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 749927002261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927002262 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 749927002263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927002264 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 749927002265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927002266 S-adenosylmethionine binding site [chemical binding]; other site 749927002267 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 749927002268 isocitrate dehydrogenase; Validated; Region: PRK08299 749927002269 Bacterial SH3 domain; Region: SH3_3; pfam08239 749927002270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927002271 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 749927002272 WHG domain; Region: WHG; pfam13305 749927002273 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 749927002274 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 749927002275 putative active site [active] 749927002276 putative catalytic site [active] 749927002277 putative DNA binding site [nucleotide binding]; other site 749927002278 putative phosphate binding site [ion binding]; other site 749927002279 metal binding site A [ion binding]; metal-binding site 749927002280 putative AP binding site [nucleotide binding]; other site 749927002281 putative metal binding site B [ion binding]; other site 749927002282 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 749927002283 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 749927002284 active site 749927002285 HIGH motif; other site 749927002286 dimer interface [polypeptide binding]; other site 749927002287 KMSKS motif; other site 749927002288 AAA domain; Region: AAA_17; cl19128 749927002289 AAA domain; Region: AAA_33; pfam13671 749927002290 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 749927002291 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927002292 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927002293 active site 749927002294 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927002295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927002296 dimerization interface [polypeptide binding]; other site 749927002297 putative DNA binding site [nucleotide binding]; other site 749927002298 putative Zn2+ binding site [ion binding]; other site 749927002299 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 749927002300 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 749927002301 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927002302 Subtilase family; Region: Peptidase_S8; pfam00082 749927002303 active site 749927002304 catalytic residues [active] 749927002305 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 749927002306 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 749927002307 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 749927002308 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 749927002309 L-aspartate oxidase; Provisional; Region: PRK06175 749927002310 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 749927002311 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 749927002312 putative Iron-sulfur protein interface [polypeptide binding]; other site 749927002313 putative proximal heme binding site [chemical binding]; other site 749927002314 putative SdhC-like subunit interface [polypeptide binding]; other site 749927002315 putative distal heme binding site [chemical binding]; other site 749927002316 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 749927002317 putative Iron-sulfur protein interface [polypeptide binding]; other site 749927002318 putative proximal heme binding site [chemical binding]; other site 749927002319 putative SdhD-like interface [polypeptide binding]; other site 749927002320 putative distal heme binding site [chemical binding]; other site 749927002321 alpha-galactosidase; Region: PLN02808; cl17638 749927002322 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 749927002323 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 749927002324 Glycosyl-hydrolase 97 N-terminal; Region: GH97_N; pfam14508 749927002325 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 749927002326 Glycosyl-hydrolase 97 C-terminal, oligomerization; Region: GH97_C; pfam14509 749927002327 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 749927002328 ligand binding site [chemical binding]; other site 749927002329 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 749927002330 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927002331 Walker A/P-loop; other site 749927002332 ATP binding site [chemical binding]; other site 749927002333 Q-loop/lid; other site 749927002334 ABC transporter signature motif; other site 749927002335 Walker B; other site 749927002336 D-loop; other site 749927002337 H-loop/switch region; other site 749927002338 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 749927002339 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 749927002340 TM-ABC transporter signature motif; other site 749927002341 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 749927002342 TM-ABC transporter signature motif; other site 749927002343 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 749927002344 active site 749927002345 catalytic motif [active] 749927002346 Zn binding site [ion binding]; other site 749927002347 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 749927002348 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 749927002349 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 749927002350 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 749927002351 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 749927002352 adenosine deaminase; Provisional; Region: PRK09358 749927002353 active site 749927002354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927002355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927002356 putative substrate translocation pore; other site 749927002357 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927002358 ATP binding site [chemical binding]; other site 749927002359 putative Mg++ binding site [ion binding]; other site 749927002360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927002361 nucleotide binding region [chemical binding]; other site 749927002362 ATP-binding site [chemical binding]; other site 749927002363 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 749927002364 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 749927002365 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927002366 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 749927002367 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 749927002368 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927002369 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 749927002370 putative NAD(P) binding site [chemical binding]; other site 749927002371 catalytic Zn binding site [ion binding]; other site 749927002372 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927002373 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927002374 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927002375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927002376 dimer interface [polypeptide binding]; other site 749927002377 conserved gate region; other site 749927002378 putative PBP binding loops; other site 749927002379 ABC-ATPase subunit interface; other site 749927002380 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927002381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927002382 dimer interface [polypeptide binding]; other site 749927002383 conserved gate region; other site 749927002384 putative PBP binding loops; other site 749927002385 ABC-ATPase subunit interface; other site 749927002386 Divergent 4Fe-4S mono-cluster; Region: Fer4_19; cl01443 749927002387 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927002388 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927002389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927002390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927002391 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 749927002392 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927002393 NAD(P) binding site [chemical binding]; other site 749927002394 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927002395 NAD(P) binding site [chemical binding]; other site 749927002396 catalytic residues [active] 749927002397 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 749927002398 intersubunit interface [polypeptide binding]; other site 749927002399 active site 749927002400 catalytic residue [active] 749927002401 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 749927002402 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; cl19753 749927002403 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 749927002404 active site 749927002405 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927002406 active site 749927002407 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 749927002408 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 749927002409 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 749927002410 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927002411 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 749927002412 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927002413 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927002414 WHG domain; Region: WHG; pfam13305 749927002415 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927002416 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 749927002417 DNA binding residues [nucleotide binding] 749927002418 putative dimer interface [polypeptide binding]; other site 749927002419 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927002420 active site 749927002421 catalytic tetrad [active] 749927002422 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 749927002423 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 749927002424 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 749927002425 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 749927002426 active site 749927002427 substrate binding site [chemical binding]; other site 749927002428 FMN binding site [chemical binding]; other site 749927002429 putative catalytic residues [active] 749927002430 Cytochrome P450; Region: p450; cl12078 749927002431 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 749927002432 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927002433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927002434 active site 749927002435 phosphorylation site [posttranslational modification] 749927002436 intermolecular recognition site; other site 749927002437 dimerization interface [polypeptide binding]; other site 749927002438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 749927002439 DNA binding site [nucleotide binding] 749927002440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927002441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927002442 dimer interface [polypeptide binding]; other site 749927002443 phosphorylation site [posttranslational modification] 749927002444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927002445 ATP binding site [chemical binding]; other site 749927002446 Mg2+ binding site [ion binding]; other site 749927002447 G-X-G motif; other site 749927002448 HEAT repeats; Region: HEAT_2; pfam13646 749927002449 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 749927002450 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 749927002451 dimer interface [polypeptide binding]; other site 749927002452 motif 1; other site 749927002453 active site 749927002454 motif 2; other site 749927002455 motif 3; other site 749927002456 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 749927002457 anticodon binding site; other site 749927002458 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 749927002459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927002460 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927002461 active site 749927002462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927002463 non-specific DNA binding site [nucleotide binding]; other site 749927002464 salt bridge; other site 749927002465 sequence-specific DNA binding site [nucleotide binding]; other site 749927002466 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927002467 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 749927002468 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 749927002469 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 749927002470 active site 749927002471 substrate binding site [chemical binding]; other site 749927002472 metal binding site [ion binding]; metal-binding site 749927002473 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927002474 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927002475 homodimer interface [polypeptide binding]; other site 749927002476 active site 749927002477 TDP-binding site; other site 749927002478 acceptor substrate-binding pocket; other site 749927002479 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 749927002480 purine nucleoside phosphorylase; Provisional; Region: PRK08202 749927002481 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 749927002482 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg5; cd04780 749927002483 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927002484 DNA binding residues [nucleotide binding] 749927002485 putative dimer interface [polypeptide binding]; other site 749927002486 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927002487 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927002488 active site 749927002489 ATP binding site [chemical binding]; other site 749927002490 substrate binding site [chemical binding]; other site 749927002491 activation loop (A-loop); other site 749927002492 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 749927002493 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 749927002494 heterodimer interface [polypeptide binding]; other site 749927002495 substrate interaction site [chemical binding]; other site 749927002496 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 749927002497 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 749927002498 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 749927002499 active site 749927002500 substrate binding site [chemical binding]; other site 749927002501 coenzyme B12 binding site [chemical binding]; other site 749927002502 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 749927002503 B12 binding site [chemical binding]; other site 749927002504 cobalt ligand [ion binding]; other site 749927002505 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 749927002506 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 749927002507 Walker A; other site 749927002508 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 749927002509 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 749927002510 metal binding site [ion binding]; metal-binding site 749927002511 putative dimer interface [polypeptide binding]; other site 749927002512 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 749927002513 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 749927002514 putative active site [active] 749927002515 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 749927002516 dimerization interface [polypeptide binding]; other site 749927002517 putative active site pocket [active] 749927002518 putative catalytic residue [active] 749927002519 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 749927002520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927002521 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927002522 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 749927002523 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 749927002524 active site 749927002525 putative catalytic site [active] 749927002526 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 749927002527 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 749927002528 glycerol kinase; Provisional; Region: glpK; PRK00047 749927002529 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 749927002530 N- and C-terminal domain interface [polypeptide binding]; other site 749927002531 active site 749927002532 MgATP binding site [chemical binding]; other site 749927002533 catalytic site [active] 749927002534 metal binding site [ion binding]; metal-binding site 749927002535 putative homotetramer interface [polypeptide binding]; other site 749927002536 glycerol binding site [chemical binding]; other site 749927002537 homodimer interface [polypeptide binding]; other site 749927002538 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 749927002539 amphipathic channel; other site 749927002540 Asn-Pro-Ala signature motifs; other site 749927002541 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 749927002542 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927002543 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927002544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927002545 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 749927002546 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927002547 putative NAD(P) binding site [chemical binding]; other site 749927002548 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927002549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927002550 Coenzyme A binding pocket [chemical binding]; other site 749927002551 phosphoribosylformylglycinamidine synthase; Provisional; Region: PLN03206 749927002552 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 749927002553 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 749927002554 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 749927002555 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749927002556 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 749927002557 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 749927002558 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 749927002559 carboxyltransferase (CT) interaction site; other site 749927002560 biotinylation site [posttranslational modification]; other site 749927002561 SseB protein N-terminal domain; Region: SseB; pfam07179 749927002562 RNA ligase; Region: RNA_ligase; cl19220 749927002563 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 749927002564 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 749927002565 active site 749927002566 dimer interface [polypeptide binding]; other site 749927002567 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 749927002568 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 749927002569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927002570 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 749927002571 putative substrate translocation pore; other site 749927002572 Transcriptional regulator PadR-like family; Region: PadR; cl17335 749927002573 TROVE domain; Region: TROVE; pfam05731 749927002574 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 749927002575 metal ion-dependent adhesion site (MIDAS); other site 749927002576 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927002577 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927002578 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927002579 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 749927002580 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 749927002581 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 749927002582 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 749927002583 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927002584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 749927002585 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927002586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927002587 active site 749927002588 phosphorylation site [posttranslational modification] 749927002589 intermolecular recognition site; other site 749927002590 dimerization interface [polypeptide binding]; other site 749927002591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927002592 DNA binding residues [nucleotide binding] 749927002593 dimerization interface [polypeptide binding]; other site 749927002594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927002595 Histidine kinase; Region: HisKA_3; pfam07730 749927002596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927002597 Mg2+ binding site [ion binding]; other site 749927002598 G-X-G motif; other site 749927002599 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 749927002600 putative hydrophobic ligand binding site [chemical binding]; other site 749927002601 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927002602 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927002603 putative Zn2+ binding site [ion binding]; other site 749927002604 putative DNA binding site [nucleotide binding]; other site 749927002605 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 749927002606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927002607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927002608 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927002609 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927002610 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927002611 putative DNA binding site [nucleotide binding]; other site 749927002612 dimerization interface [polypeptide binding]; other site 749927002613 putative Zn2+ binding site [ion binding]; other site 749927002614 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 749927002615 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 749927002616 short chain dehydrogenase; Provisional; Region: PRK06500 749927002617 classical (c) SDRs; Region: SDR_c; cd05233 749927002618 NAD(P) binding site [chemical binding]; other site 749927002619 active site 749927002620 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 749927002621 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 749927002622 conserved cys residue [active] 749927002623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927002624 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 749927002625 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927002626 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927002627 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 749927002628 dimerization interface [polypeptide binding]; other site 749927002629 substrate binding pocket [chemical binding]; other site 749927002630 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927002631 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927002632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927002633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927002634 S-adenosylmethionine binding site [chemical binding]; other site 749927002635 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 749927002636 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 749927002637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927002638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 749927002639 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 749927002640 FMN binding site [chemical binding]; other site 749927002641 active site 749927002642 substrate binding site [chemical binding]; other site 749927002643 catalytic residue [active] 749927002644 active site 749927002645 metal binding site [ion binding]; metal-binding site 749927002646 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927002647 Histidine kinase; Region: HisKA_3; pfam07730 749927002648 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 749927002649 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927002650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927002651 active site 749927002652 phosphorylation site [posttranslational modification] 749927002653 intermolecular recognition site; other site 749927002654 dimerization interface [polypeptide binding]; other site 749927002655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927002656 DNA binding residues [nucleotide binding] 749927002657 dimerization interface [polypeptide binding]; other site 749927002658 NlpC/P60 family; Region: NLPC_P60; pfam00877 749927002659 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 749927002660 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 749927002661 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 749927002662 Bacterial PH domain; Region: bPH_2; pfam03703 749927002663 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 749927002664 active site 749927002665 catalytic residues [active] 749927002666 metal binding site [ion binding]; metal-binding site 749927002667 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 749927002668 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 749927002669 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 749927002670 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 749927002671 active site 749927002672 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927002673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927002674 active site 749927002675 phosphorylation site [posttranslational modification] 749927002676 intermolecular recognition site; other site 749927002677 dimerization interface [polypeptide binding]; other site 749927002678 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927002679 DNA binding site [nucleotide binding] 749927002680 HAMP domain; Region: HAMP; pfam00672 749927002681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927002682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927002683 dimer interface [polypeptide binding]; other site 749927002684 phosphorylation site [posttranslational modification] 749927002685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927002686 ATP binding site [chemical binding]; other site 749927002687 Mg2+ binding site [ion binding]; other site 749927002688 G-X-G motif; other site 749927002689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927002690 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927002691 DNA binding residues [nucleotide binding] 749927002692 dimerization interface [polypeptide binding]; other site 749927002693 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927002694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927002695 active site 749927002696 phosphorylation site [posttranslational modification] 749927002697 intermolecular recognition site; other site 749927002698 dimerization interface [polypeptide binding]; other site 749927002699 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927002700 DNA binding residues [nucleotide binding] 749927002701 dimerization interface [polypeptide binding]; other site 749927002702 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927002703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927002704 NAD(P) binding site [chemical binding]; other site 749927002705 active site 749927002706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927002707 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927002708 putative substrate translocation pore; other site 749927002709 Predicted membrane protein [Function unknown]; Region: COG2246 749927002710 GtrA-like protein; Region: GtrA; pfam04138 749927002711 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927002712 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927002713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 749927002714 DNA binding residues [nucleotide binding] 749927002715 Putative zinc-finger; Region: zf-HC2; pfam13490 749927002716 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 749927002717 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 749927002718 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 749927002719 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927002720 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 749927002721 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 749927002722 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927002723 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927002724 acyl-activating enzyme (AAE) consensus motif; other site 749927002725 AMP binding site [chemical binding]; other site 749927002726 active site 749927002727 CoA binding site [chemical binding]; other site 749927002728 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927002729 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927002730 active site 749927002731 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 749927002732 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927002733 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927002734 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 749927002735 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 749927002736 Predicted membrane protein [Function unknown]; Region: COG2259 749927002737 TIGR03089 family protein; Region: TIGR03089 749927002738 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927002739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927002740 NAD(P) binding site [chemical binding]; other site 749927002741 active site 749927002742 hypothetical protein; Region: PHA02357 749927002743 Transcriptional regulator [Transcription]; Region: LytR; COG1316 749927002744 Transcriptional regulator [Transcription]; Region: LytR; COG1316 749927002745 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 749927002746 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 749927002747 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 749927002748 NAD binding site [chemical binding]; other site 749927002749 substrate binding site [chemical binding]; other site 749927002750 homodimer interface [polypeptide binding]; other site 749927002751 active site 749927002752 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 749927002753 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 749927002754 NADP binding site [chemical binding]; other site 749927002755 active site 749927002756 putative substrate binding site [chemical binding]; other site 749927002757 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 749927002758 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927002759 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 749927002760 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 749927002761 Probable Catalytic site; other site 749927002762 metal-binding site 749927002763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927002764 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927002765 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 749927002766 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 749927002767 Probable Catalytic site; other site 749927002768 metal-binding site 749927002769 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 749927002770 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927002771 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927002772 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 749927002773 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 749927002774 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 749927002775 Probable Catalytic site; other site 749927002776 metal-binding site 749927002777 superantigen-like protein; Reviewed; Region: PRK13335 749927002778 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 749927002779 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 749927002780 active site 749927002781 Substrate binding site; other site 749927002782 Mg++ binding site; other site 749927002783 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 749927002784 putative trimer interface [polypeptide binding]; other site 749927002785 putative CoA binding site [chemical binding]; other site 749927002786 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 749927002787 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 749927002788 minor groove reading motif; other site 749927002789 helix-hairpin-helix signature motif; other site 749927002790 Predicted transcriptional regulators [Transcription]; Region: COG1725 749927002791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927002792 DNA-binding site [nucleotide binding]; DNA binding site 749927002793 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 749927002794 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 749927002795 nudix motif; other site 749927002796 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 749927002797 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 749927002798 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 749927002799 FMN binding site [chemical binding]; other site 749927002800 dimer interface [polypeptide binding]; other site 749927002801 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 749927002802 dimer interface [polypeptide binding]; other site 749927002803 phosphate binding site [ion binding]; other site 749927002804 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 749927002805 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927002806 Coenzyme A binding pocket [chemical binding]; other site 749927002807 Ferredoxin [Energy production and conversion]; Region: COG1146 749927002808 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 749927002809 4Fe-4S binding domain; Region: Fer4; pfam00037 749927002810 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 749927002811 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927002812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927002813 homodimer interface [polypeptide binding]; other site 749927002814 catalytic residue [active] 749927002815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927002816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927002817 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927002818 hypothetical protein; Provisional; Region: PRK06184 749927002819 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927002820 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749927002821 CHAD domain; Region: CHAD; pfam05235 749927002822 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 749927002823 Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789 749927002824 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 749927002825 putative trimer interface [polypeptide binding]; other site 749927002826 putative CoA binding site [chemical binding]; other site 749927002827 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 749927002828 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 749927002829 metal binding site [ion binding]; metal-binding site 749927002830 putative dimer interface [polypeptide binding]; other site 749927002831 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 749927002832 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 749927002833 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 749927002834 putative active site [active] 749927002835 potential frameshift: common BLAST hit: gi|271965254|ref|YP_003339450.1| Zinc metalloprotease (elastase)-like protein 749927002836 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 749927002837 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 749927002838 active site 749927002839 metal binding site [ion binding]; metal-binding site 749927002840 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 749927002841 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 749927002842 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 749927002843 active site 749927002844 Zn binding site [ion binding]; other site 749927002845 BDLF3; Provisional; Region: PHA03255 749927002846 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 749927002847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927002848 non-specific DNA binding site [nucleotide binding]; other site 749927002849 salt bridge; other site 749927002850 sequence-specific DNA binding site [nucleotide binding]; other site 749927002851 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 749927002852 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 749927002853 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 749927002854 active site 749927002855 Zn binding site [ion binding]; other site 749927002856 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 749927002857 aromatic chitin/cellulose binding site residues [chemical binding]; other site 749927002858 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927002859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927002860 non-specific DNA binding site [nucleotide binding]; other site 749927002861 salt bridge; other site 749927002862 sequence-specific DNA binding site [nucleotide binding]; other site 749927002863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927002864 binding surface 749927002865 TPR motif; other site 749927002866 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927002867 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 749927002868 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 749927002869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927002870 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927002871 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 749927002872 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 749927002873 Probable Catalytic site; other site 749927002874 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 749927002875 Methyltransferase domain; Region: Methyltransf_24; pfam13578 749927002876 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 749927002877 putative acyl-acceptor binding pocket; other site 749927002878 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 749927002879 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 749927002880 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 749927002881 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 749927002882 Walker A/P-loop; other site 749927002883 ATP binding site [chemical binding]; other site 749927002884 Q-loop/lid; other site 749927002885 ABC transporter signature motif; other site 749927002886 Walker B; other site 749927002887 D-loop; other site 749927002888 H-loop/switch region; other site 749927002889 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 749927002890 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927002891 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 749927002892 Walker A/P-loop; other site 749927002893 ATP binding site [chemical binding]; other site 749927002894 Q-loop/lid; other site 749927002895 ABC transporter signature motif; other site 749927002896 Walker B; other site 749927002897 D-loop; other site 749927002898 H-loop/switch region; other site 749927002899 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 749927002900 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 749927002901 Transcriptional regulator PadR-like family; Region: PadR; cl17335 749927002902 DivIVA domain; Region: DivI1A_domain; TIGR03544 749927002903 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 749927002904 hydrophobic ligand binding site; other site 749927002905 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 749927002906 enoyl-CoA hydratase; Provisional; Region: PRK08140 749927002907 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927002908 substrate binding site [chemical binding]; other site 749927002909 oxyanion hole (OAH) forming residues; other site 749927002910 trimer interface [polypeptide binding]; other site 749927002911 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 749927002912 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 749927002913 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 749927002914 interface (dimer of trimers) [polypeptide binding]; other site 749927002915 Substrate-binding/catalytic site; other site 749927002916 Zn-binding sites [ion binding]; other site 749927002917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927002918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927002919 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 749927002920 putative dimerization interface [polypeptide binding]; other site 749927002921 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 749927002922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927002923 putative substrate translocation pore; other site 749927002924 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 749927002925 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 749927002926 Transposase [DNA replication, recombination, and repair]; Region: COG5433 749927002927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927002928 S-adenosylmethionine binding site [chemical binding]; other site 749927002929 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 749927002930 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927002931 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927002932 DNA binding residues [nucleotide binding] 749927002933 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 749927002934 Putative zinc-finger; Region: zf-HC2; pfam13490 749927002935 Trypsin; Region: Trypsin; pfam00089 749927002936 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927002937 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 749927002938 sec-independent translocase; Provisional; Region: PRK03100 749927002939 Domain of unknown function DUF59; Region: DUF59; cl00941 749927002940 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 749927002941 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 749927002942 Walker A motif; other site 749927002943 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 749927002944 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 749927002945 PRC-barrel domain; Region: PRC; pfam05239 749927002946 MgtE intracellular N domain; Region: MgtE_N; smart00924 749927002947 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 749927002948 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 749927002949 prohibitin homologues; Region: PHB; smart00244 749927002950 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826 749927002951 trimer interface [polypeptide binding]; other site 749927002952 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 749927002953 YppG-like protein; Region: YppG; pfam14179 749927002954 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 749927002955 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927002956 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927002957 active site 749927002958 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927002959 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927002960 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927002961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927002962 dimer interface [polypeptide binding]; other site 749927002963 conserved gate region; other site 749927002964 putative PBP binding loops; other site 749927002965 ABC-ATPase subunit interface; other site 749927002966 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927002967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927002968 dimer interface [polypeptide binding]; other site 749927002969 conserved gate region; other site 749927002970 putative PBP binding loops; other site 749927002971 ABC-ATPase subunit interface; other site 749927002972 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 749927002973 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 749927002974 Walker A/P-loop; other site 749927002975 ATP binding site [chemical binding]; other site 749927002976 Q-loop/lid; other site 749927002977 ABC transporter signature motif; other site 749927002978 Walker B; other site 749927002979 D-loop; other site 749927002980 H-loop/switch region; other site 749927002981 PspC domain; Region: PspC; pfam04024 749927002982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927002983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927002984 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 749927002985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927002986 putative substrate translocation pore; other site 749927002987 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927002988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927002989 active site 749927002990 phosphorylation site [posttranslational modification] 749927002991 intermolecular recognition site; other site 749927002992 dimerization interface [polypeptide binding]; other site 749927002993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927002994 DNA binding residues [nucleotide binding] 749927002995 dimerization interface [polypeptide binding]; other site 749927002996 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927002997 Histidine kinase; Region: HisKA_3; pfam07730 749927002998 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 749927002999 CAAX protease self-immunity; Region: Abi; pfam02517 749927003000 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927003001 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927003002 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927003003 DNA binding residues [nucleotide binding] 749927003004 ParB-like nuclease domain; Region: ParBc; cl02129 749927003005 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927003006 active site 749927003007 metal binding site [ion binding]; metal-binding site 749927003008 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 749927003009 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 749927003010 oligomer interface [polypeptide binding]; other site 749927003011 metal binding site [ion binding]; metal-binding site 749927003012 metal binding site [ion binding]; metal-binding site 749927003013 putative Cl binding site [ion binding]; other site 749927003014 basic sphincter; other site 749927003015 hydrophobic gate; other site 749927003016 periplasmic entrance; other site 749927003017 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 749927003018 putative active site [active] 749927003019 putative catalytic site [active] 749927003020 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 749927003021 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 749927003022 nudix motif; other site 749927003023 Bacterial PH domain; Region: bPH_2; pfam03703 749927003024 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 749927003025 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 749927003026 active site 749927003027 MarC family integral membrane protein; Region: MarC; cl00919 749927003028 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927003029 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 749927003030 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 749927003031 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 749927003032 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 749927003033 DEAD-like helicases superfamily; Region: DEXDc; smart00487 749927003034 ATP binding site [chemical binding]; other site 749927003035 Mg++ binding site [ion binding]; other site 749927003036 motif III; other site 749927003037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927003038 nucleotide binding region [chemical binding]; other site 749927003039 ATP-binding site [chemical binding]; other site 749927003040 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 749927003041 dinuclear metal binding motif [ion binding]; other site 749927003042 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 749927003043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927003044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003045 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 749927003046 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927003047 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927003048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927003049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003050 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927003051 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927003052 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 749927003053 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 749927003054 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 749927003055 ATP binding site [chemical binding]; other site 749927003056 substrate interface [chemical binding]; other site 749927003057 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 749927003058 active site residue [active] 749927003059 TIGR02569 family protein; Region: TIGR02569_actnb 749927003060 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 749927003061 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749927003062 molybdopterin cofactor binding site; other site 749927003063 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 749927003064 molybdopterin cofactor binding site; other site 749927003065 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 749927003066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927003067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927003068 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 749927003069 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 749927003070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927003071 putative substrate translocation pore; other site 749927003072 nitrite reductase subunit NirD; Provisional; Region: PRK14989 749927003073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927003074 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 749927003075 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 749927003076 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 749927003077 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 749927003078 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 749927003079 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 749927003080 active site 749927003081 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 749927003082 DNA binding site [nucleotide binding] 749927003083 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 749927003084 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 749927003085 Winged helix DNA-binding domain; Region: HTH_42; cl19833 749927003086 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 749927003087 Predicted transcriptional regulator [Transcription]; Region: COG2378 749927003088 HTH domain; Region: HTH_11; pfam08279 749927003089 WYL domain; Region: WYL; pfam13280 749927003090 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 749927003091 active site 749927003092 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 749927003093 DNA binding site [nucleotide binding] 749927003094 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 749927003095 active site 749927003096 Part of AAA domain; Region: AAA_19; pfam13245 749927003097 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 749927003098 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 749927003099 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 749927003100 Part of AAA domain; Region: AAA_19; pfam13245 749927003101 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 749927003102 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 749927003103 Predicted membrane protein [Function unknown]; Region: COG4270 749927003104 Ion channel; Region: Ion_trans_2; pfam07885 749927003105 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 749927003106 TrkA-N domain; Region: TrkA_N; pfam02254 749927003107 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 749927003108 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 749927003109 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 749927003110 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 749927003111 MoxR-like ATPases [General function prediction only]; Region: COG0714 749927003112 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 749927003113 Domain of unknown function DUF11; Region: DUF11; cl17728 749927003114 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 749927003115 Protein of unknown function DUF58; Region: DUF58; pfam01882 749927003116 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 749927003117 RDD family; Region: RDD; pfam06271 749927003118 YppG-like protein; Region: YppG; pfam14179 749927003119 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927003120 active site 749927003121 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 749927003122 Predicted membrane protein (DUF2207); Region: DUF2207; cl19878 749927003123 Predicted membrane protein (DUF2207); Region: DUF2207; cl19878 749927003124 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 749927003125 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 749927003126 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 749927003127 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 749927003128 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 749927003129 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 749927003130 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 749927003131 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 749927003132 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 749927003133 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 749927003134 putative NADH binding site [chemical binding]; other site 749927003135 putative active site [active] 749927003136 nudix motif; other site 749927003137 putative metal binding site [ion binding]; other site 749927003138 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927003139 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927003140 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927003141 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927003142 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927003143 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927003144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927003145 dimer interface [polypeptide binding]; other site 749927003146 putative PBP binding loops; other site 749927003147 ABC-ATPase subunit interface; other site 749927003148 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927003149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927003150 dimer interface [polypeptide binding]; other site 749927003151 conserved gate region; other site 749927003152 putative PBP binding loops; other site 749927003153 ABC-ATPase subunit interface; other site 749927003154 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 749927003155 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 749927003156 NAD binding site [chemical binding]; other site 749927003157 sugar binding site [chemical binding]; other site 749927003158 divalent metal binding site [ion binding]; other site 749927003159 tetramer (dimer of dimers) interface [polypeptide binding]; other site 749927003160 dimer interface [polypeptide binding]; other site 749927003161 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 749927003162 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927003163 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927003164 hydrophobic ligand binding site; other site 749927003165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927003166 dimerization interface [polypeptide binding]; other site 749927003167 putative DNA binding site [nucleotide binding]; other site 749927003168 putative Zn2+ binding site [ion binding]; other site 749927003169 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 749927003170 GntP family permease; Region: GntP_permease; pfam02447 749927003171 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 749927003172 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 749927003173 AAA domain; Region: AAA_33; pfam13671 749927003174 ATP-binding site [chemical binding]; other site 749927003175 Gluconate-6-phosphate binding site [chemical binding]; other site 749927003176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927003177 DNA-binding site [nucleotide binding]; DNA binding site 749927003178 transcriptional regulator NanR; Provisional; Region: PRK03837 749927003179 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 749927003180 CobD/Cbib protein; Region: CobD_Cbib; cl00561 749927003181 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 749927003182 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 749927003183 Low molecular weight phosphatase family; Region: LMWPc; cd00115 749927003184 active site 749927003185 Chorismate mutase type II; Region: CM_2; cl00693 749927003186 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 749927003187 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 749927003188 Putative zinc ribbon domain; Region: DUF164; pfam02591 749927003189 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 749927003190 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 749927003191 RNA/DNA hybrid binding site [nucleotide binding]; other site 749927003192 active site 749927003193 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927003194 catalytic core [active] 749927003195 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 749927003196 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 749927003197 transmembrane helices; other site 749927003198 AAA ATPase domain; Region: AAA_16; pfam13191 749927003199 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927003201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927003202 DNA binding residues [nucleotide binding] 749927003203 dimerization interface [polypeptide binding]; other site 749927003204 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 749927003205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927003206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927003207 DNA binding residues [nucleotide binding] 749927003208 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 749927003209 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 749927003210 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 749927003211 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 749927003212 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927003213 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927003214 Reductase C-terminal; Region: Reductase_C; pfam14759 749927003215 AAA-like domain; Region: AAA_10; pfam12846 749927003216 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 749927003217 NlpC/P60 family; Region: NLPC_P60; pfam00877 749927003218 Mid-1-related chloride channel (MCLC); Region: MCLC; pfam05934 749927003219 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927003220 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 749927003221 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 749927003222 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 749927003223 intersubunit interface [polypeptide binding]; other site 749927003224 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927003225 NAD(P) binding site [chemical binding]; other site 749927003226 catalytic residues [active] 749927003227 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927003228 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927003229 inhibitor-cofactor binding pocket; inhibition site 749927003230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927003231 catalytic residue [active] 749927003232 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 749927003233 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 749927003234 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927003235 Cache domain; Region: Cache_1; pfam02743 749927003236 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927003237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927003238 DNA-binding site [nucleotide binding]; DNA binding site 749927003239 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 749927003240 tetrameric interface [polypeptide binding]; other site 749927003241 NAD binding site [chemical binding]; other site 749927003242 catalytic residues [active] 749927003243 substrate binding site [chemical binding]; other site 749927003244 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 749927003245 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 749927003246 Walker A/P-loop; other site 749927003247 ATP binding site [chemical binding]; other site 749927003248 Q-loop/lid; other site 749927003249 ABC transporter signature motif; other site 749927003250 Walker B; other site 749927003251 D-loop; other site 749927003252 H-loop/switch region; other site 749927003253 TOBE domain; Region: TOBE_2; pfam08402 749927003254 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 749927003255 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927003256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927003257 dimer interface [polypeptide binding]; other site 749927003258 conserved gate region; other site 749927003259 putative PBP binding loops; other site 749927003260 ABC-ATPase subunit interface; other site 749927003261 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927003262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927003263 dimer interface [polypeptide binding]; other site 749927003264 conserved gate region; other site 749927003265 putative PBP binding loops; other site 749927003266 ABC-ATPase subunit interface; other site 749927003267 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927003268 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927003269 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 749927003270 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 749927003271 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 749927003272 oligomerization interface [polypeptide binding]; other site 749927003273 active site 749927003274 metal binding site [ion binding]; metal-binding site 749927003275 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 749927003276 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 749927003277 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 749927003278 dimer interface [polypeptide binding]; other site 749927003279 putative anticodon binding site; other site 749927003280 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 749927003281 motif 1; other site 749927003282 dimer interface [polypeptide binding]; other site 749927003283 active site 749927003284 motif 2; other site 749927003285 motif 3; other site 749927003286 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927003287 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 749927003288 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 749927003289 DNA binding site [nucleotide binding] 749927003290 active site 749927003291 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 749927003292 NAD synthetase; Provisional; Region: PRK13981 749927003293 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 749927003294 multimer interface [polypeptide binding]; other site 749927003295 active site 749927003296 catalytic triad [active] 749927003297 protein interface 1 [polypeptide binding]; other site 749927003298 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 749927003299 homodimer interface [polypeptide binding]; other site 749927003300 NAD binding pocket [chemical binding]; other site 749927003301 ATP binding pocket [chemical binding]; other site 749927003302 Mg binding site [ion binding]; other site 749927003303 active-site loop [active] 749927003304 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 749927003305 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 749927003306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927003307 nucleotide binding region [chemical binding]; other site 749927003308 ATP-binding site [chemical binding]; other site 749927003309 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 749927003310 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927003311 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927003312 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 749927003313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927003314 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927003315 putative substrate translocation pore; other site 749927003316 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 749927003317 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 749927003318 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 749927003319 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 749927003320 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927003321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927003322 putative DNA binding site [nucleotide binding]; other site 749927003323 putative Zn2+ binding site [ion binding]; other site 749927003324 AsnC family; Region: AsnC_trans_reg; pfam01037 749927003325 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 749927003326 active site residue [active] 749927003327 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 749927003328 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 749927003329 catalytic triad [active] 749927003330 potential frameshift: common BLAST hit: gi|256375057|ref|YP_003098717.1| phosphate transporter 749927003331 Phosphate transporter family; Region: PHO4; cl00396 749927003332 Phosphate transporter family; Region: PHO4; pfam01384 749927003333 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 749927003334 Protein involved in formate dehydrogenase formation; Region: FdhE; cl19312 749927003335 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 749927003336 metal binding triad; other site 749927003337 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 749927003338 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 749927003339 metal binding triad; other site 749927003340 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 749927003341 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 749927003342 active site 749927003343 glutamine synthetase, type I; Region: GlnA; TIGR00653 749927003344 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 749927003345 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 749927003346 RDD family; Region: RDD; pfam06271 749927003347 Hedgehog signalling target; Region: TALPID3; pfam15324 749927003348 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 749927003349 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 749927003350 Part of AAA domain; Region: AAA_19; pfam13245 749927003351 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 749927003352 HRDC domain; Region: HRDC; pfam00570 749927003353 Transcription factor WhiB; Region: Whib; pfam02467 749927003354 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749927003355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927003356 S-adenosylmethionine binding site [chemical binding]; other site 749927003357 ABC1 family; Region: ABC1; pfam03109 749927003358 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 749927003359 active site 749927003360 ATP binding site [chemical binding]; other site 749927003361 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 749927003362 catalytic loop [active] 749927003363 activation loop (A-loop); other site 749927003364 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 749927003365 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 749927003366 Protein of unknown function DUF45; Region: DUF45; cl00636 749927003367 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 749927003368 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 749927003369 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 749927003370 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 749927003371 hypothetical protein; Validated; Region: PRK00068 749927003372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927003373 hypothetical protein; Provisional; Region: PRK08244 749927003374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003375 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927003376 peptide chain release factor 2; Validated; Region: prfB; PRK00578 749927003377 This domain is found in peptide chain release factors; Region: PCRF; smart00937 749927003378 RF-1 domain; Region: RF-1; pfam00472 749927003379 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 749927003380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927003381 Walker A/P-loop; other site 749927003382 ATP binding site [chemical binding]; other site 749927003383 Q-loop/lid; other site 749927003384 ABC transporter signature motif; other site 749927003385 Walker B; other site 749927003386 D-loop; other site 749927003387 H-loop/switch region; other site 749927003388 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 749927003389 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 749927003390 FtsX-like permease family; Region: FtsX; pfam02687 749927003391 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 749927003392 SmpB-tmRNA interface; other site 749927003393 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 749927003394 active site 749927003395 Acyltransferase family; Region: Acyl_transf_3; cl19154 749927003396 Domain of unknown function (DUF336); Region: DUF336; cl01249 749927003397 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927003398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927003399 active site 749927003400 phosphorylation site [posttranslational modification] 749927003401 intermolecular recognition site; other site 749927003402 dimerization interface [polypeptide binding]; other site 749927003403 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927003404 DNA binding residues [nucleotide binding] 749927003405 dimerization interface [polypeptide binding]; other site 749927003406 Putative sensor; Region: Sensor; pfam13796 749927003407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927003408 Histidine kinase; Region: HisKA_3; pfam07730 749927003409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927003410 ATP binding site [chemical binding]; other site 749927003411 Mg2+ binding site [ion binding]; other site 749927003412 G-X-G motif; other site 749927003413 Putative sensor; Region: Sensor; pfam13796 749927003414 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927003415 metal binding site [ion binding]; metal-binding site 749927003416 active site 749927003417 I-site; other site 749927003418 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927003419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927003420 putative substrate translocation pore; other site 749927003421 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927003422 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927003423 putative DNA binding site [nucleotide binding]; other site 749927003424 putative Zn2+ binding site [ion binding]; other site 749927003425 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927003426 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 749927003427 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 749927003428 active sites [active] 749927003429 tetramer interface [polypeptide binding]; other site 749927003430 urocanate hydratase; Provisional; Region: PRK05414 749927003431 allantoate amidohydrolase; Reviewed; Region: PRK09290 749927003432 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 749927003433 active site 749927003434 metal binding site [ion binding]; metal-binding site 749927003435 dimer interface [polypeptide binding]; other site 749927003436 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 749927003437 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927003438 active site 749927003439 imidazolonepropionase; Provisional; Region: PRK14085 749927003440 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927003441 active site 749927003442 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927003443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927003444 Lipase (class 2); Region: Lipase_2; pfam01674 749927003445 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927003446 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 749927003447 active site 749927003448 catalytic triad [active] 749927003449 dimer interface [polypeptide binding]; other site 749927003450 Phosphate transporter family; Region: PHO4; pfam01384 749927003451 Histidine kinase; Region: HisKA_3; pfam07730 749927003452 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 749927003453 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927003454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927003455 active site 749927003456 phosphorylation site [posttranslational modification] 749927003457 intermolecular recognition site; other site 749927003458 dimerization interface [polypeptide binding]; other site 749927003459 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927003460 DNA binding residues [nucleotide binding] 749927003461 dimerization interface [polypeptide binding]; other site 749927003462 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927003463 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927003464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 749927003465 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 749927003466 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 749927003467 nucleotidyl binding site; other site 749927003468 metal binding site [ion binding]; metal-binding site 749927003469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927003470 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003471 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927003473 binding surface 749927003474 TPR motif; other site 749927003475 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003476 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003477 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927003478 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927003479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927003480 Walker A/P-loop; other site 749927003481 ATP binding site [chemical binding]; other site 749927003482 Q-loop/lid; other site 749927003483 ABC transporter signature motif; other site 749927003484 Walker B; other site 749927003485 D-loop; other site 749927003486 H-loop/switch region; other site 749927003487 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 749927003488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927003489 ATP binding site [chemical binding]; other site 749927003490 putative Mg++ binding site [ion binding]; other site 749927003491 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927003492 nucleotide binding region [chemical binding]; other site 749927003493 ATP-binding site [chemical binding]; other site 749927003494 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 749927003495 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 749927003496 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 749927003497 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749927003498 substrate binding pocket [chemical binding]; other site 749927003499 membrane-bound complex binding site; other site 749927003500 hinge residues; other site 749927003501 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 749927003502 Thioredoxin; Region: Thioredoxin_4; cl17273 749927003503 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 749927003504 catalytic residues [active] 749927003505 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 749927003506 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 749927003507 NlpC/P60 family; Region: NLPC_P60; pfam00877 749927003508 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 749927003509 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 749927003510 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927003511 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 749927003512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927003513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927003514 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927003515 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 749927003516 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 749927003517 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 749927003518 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927003519 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927003520 putative sugar binding sites [chemical binding]; other site 749927003521 Q-X-W motif; other site 749927003522 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 749927003523 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 749927003524 CAP-like domain; other site 749927003525 active site 749927003526 primary dimer interface [polypeptide binding]; other site 749927003527 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 749927003528 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 749927003529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927003530 ATP binding site [chemical binding]; other site 749927003531 Mg2+ binding site [ion binding]; other site 749927003532 G-X-G motif; other site 749927003533 DNA gyrase B; Region: DNA_gyraseB; pfam00204 749927003534 ATP binding site [chemical binding]; other site 749927003535 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 749927003536 active site 749927003537 metal binding site [ion binding]; metal-binding site 749927003538 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 749927003539 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 749927003540 putative active site [active] 749927003541 catalytic site [active] 749927003542 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 749927003543 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927003544 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 749927003545 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 749927003546 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927003547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927003548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003549 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927003550 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927003551 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927003552 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927003553 intermolecular salt bridges; other site 749927003554 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927003555 TM-ABC transporter signature motif; other site 749927003556 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927003557 TM-ABC transporter signature motif; other site 749927003558 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 749927003559 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927003560 Walker A/P-loop; other site 749927003561 ATP binding site [chemical binding]; other site 749927003562 Q-loop/lid; other site 749927003563 ABC transporter signature motif; other site 749927003564 Walker B; other site 749927003565 D-loop; other site 749927003566 H-loop/switch region; other site 749927003567 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 749927003568 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 749927003569 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 749927003570 putative ligand binding site [chemical binding]; other site 749927003571 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927003572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927003573 DNA binding site [nucleotide binding] 749927003574 domain linker motif; other site 749927003575 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927003576 ligand binding site [chemical binding]; other site 749927003577 dimerization interface [polypeptide binding]; other site 749927003578 Predicted ATPase [General function prediction only]; Region: COG4637 749927003579 AAA domain; Region: AAA_23; pfam13476 749927003580 Walker A/P-loop; other site 749927003581 ATP binding site [chemical binding]; other site 749927003582 AAA domain; Region: AAA_21; pfam13304 749927003583 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927003584 short chain dehydrogenase; Validated; Region: PRK08264 749927003585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927003586 NAD(P) binding site [chemical binding]; other site 749927003587 active site 749927003588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927003589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003590 WHG domain; Region: WHG; pfam13305 749927003591 Phosphotransferase enzyme family; Region: APH; pfam01636 749927003592 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 749927003593 active site 749927003594 substrate binding site [chemical binding]; other site 749927003595 ATP binding site [chemical binding]; other site 749927003596 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 749927003597 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 749927003598 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 749927003599 FAD binding pocket [chemical binding]; other site 749927003600 FAD binding motif [chemical binding]; other site 749927003601 phosphate binding motif [ion binding]; other site 749927003602 NAD binding pocket [chemical binding]; other site 749927003603 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 749927003604 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 749927003605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927003606 Walker A/P-loop; other site 749927003607 ATP binding site [chemical binding]; other site 749927003608 Q-loop/lid; other site 749927003609 ABC transporter signature motif; other site 749927003610 Walker B; other site 749927003611 D-loop; other site 749927003612 H-loop/switch region; other site 749927003613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003614 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927003615 Methyltransferase domain; Region: Methyltransf_11; pfam08241 749927003616 Membrane protein of unknown function; Region: DUF360; pfam04020 749927003617 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 749927003618 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 749927003619 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 749927003620 substrate binding pocket [chemical binding]; other site 749927003621 substrate-Mg2+ binding site; other site 749927003622 aspartate-rich region 1; other site 749927003623 aspartate-rich region 2; other site 749927003624 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 749927003625 substrate binding pocket [chemical binding]; other site 749927003626 substrate-Mg2+ binding site; other site 749927003627 aspartate-rich region 1; other site 749927003628 aspartate-rich region 2; other site 749927003629 GCN5-related N-acetyl-transferase; Region: Acetyltransf_CG; pfam14542 749927003630 FlaG protein; Region: FlaG; cl00591 749927003631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927003632 S-adenosylmethionine binding site [chemical binding]; other site 749927003633 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927003634 Ricin-type beta-trefoil; Region: RICIN; smart00458 749927003635 putative sugar binding sites [chemical binding]; other site 749927003636 Q-X-W motif; other site 749927003637 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927003638 sugar binding site [chemical binding]; other site 749927003639 classical (c) SDRs; Region: SDR_c; cd05233 749927003640 NAD(P) binding site [chemical binding]; other site 749927003641 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 749927003642 active site 749927003643 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927003644 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 749927003645 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cl19106 749927003646 Dimer interface [polypeptide binding]; other site 749927003647 anticodon binding site; other site 749927003648 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 749927003649 motif 1; other site 749927003650 dimer interface [polypeptide binding]; other site 749927003651 active site 749927003652 motif 2; other site 749927003653 motif 3; other site 749927003654 tyramine oxidase; Provisional; Region: tynA; PRK11504 749927003655 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927003656 classical (c) SDRs; Region: SDR_c; cd05233 749927003657 NAD(P) binding site [chemical binding]; other site 749927003658 active site 749927003659 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 749927003660 CGNR zinc finger; Region: zf-CGNR; pfam11706 749927003661 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927003662 haloalkane dehalogenase; Provisional; Region: PRK03592 749927003663 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927003664 sugar binding site [chemical binding]; other site 749927003665 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927003666 Interdomain contacts; other site 749927003667 Cytokine receptor motif; other site 749927003668 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927003669 Interdomain contacts; other site 749927003670 Cytokine receptor motif; other site 749927003671 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 749927003672 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 749927003673 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 749927003674 Uncharacterized conserved protein [Function unknown]; Region: COG0393 749927003675 Uncharacterized conserved protein [Function unknown]; Region: COG0393 749927003676 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 749927003677 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 749927003678 substrate binding site [chemical binding]; other site 749927003679 ATP binding site [chemical binding]; other site 749927003680 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 749927003681 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 749927003682 NAD binding site [chemical binding]; other site 749927003683 sugar binding site [chemical binding]; other site 749927003684 divalent metal binding site [ion binding]; other site 749927003685 tetramer (dimer of dimers) interface [polypeptide binding]; other site 749927003686 dimer interface [polypeptide binding]; other site 749927003687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927003688 NAD(P) binding site [chemical binding]; other site 749927003689 short chain dehydrogenase; Region: adh_short; pfam00106 749927003690 active site 749927003691 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 749927003692 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927003693 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927003694 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 749927003695 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 749927003696 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 749927003697 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 749927003698 NAD(P) binding pocket [chemical binding]; other site 749927003699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927003700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003701 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927003702 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927003703 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927003704 TIGR03086 family protein; Region: TIGR03086 749927003705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927003706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003707 Domain of unknown function DUF11; Region: DUF11; cl17728 749927003708 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 749927003709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927003710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 749927003711 DNA binding residues [nucleotide binding] 749927003712 dimerization interface [polypeptide binding]; other site 749927003713 Rhomboid family; Region: Rhomboid; pfam01694 749927003714 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 749927003715 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 749927003716 substrate binding pocket [chemical binding]; other site 749927003717 dimer interface [polypeptide binding]; other site 749927003718 inhibitor binding site; inhibition site 749927003719 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927003720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927003721 Walker A/P-loop; other site 749927003722 ATP binding site [chemical binding]; other site 749927003723 Q-loop/lid; other site 749927003724 ABC transporter signature motif; other site 749927003725 Walker B; other site 749927003726 D-loop; other site 749927003727 H-loop/switch region; other site 749927003728 Acyltransferase family; Region: Acyl_transf_3; cl19154 749927003729 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927003730 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927003731 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003732 CHAT domain; Region: CHAT; pfam12770 749927003733 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 749927003734 active site 749927003735 catalytic residues [active] 749927003736 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927003737 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927003738 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 749927003739 substrate binding pocket [chemical binding]; other site 749927003740 catalytic residues [active] 749927003741 EamA-like transporter family; Region: EamA; pfam00892 749927003742 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 749927003743 EamA-like transporter family; Region: EamA; pfam00892 749927003744 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927003745 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927003746 putative DNA binding site [nucleotide binding]; other site 749927003747 putative Zn2+ binding site [ion binding]; other site 749927003748 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 749927003749 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 749927003750 active site 749927003751 phosphorylation site [posttranslational modification] 749927003752 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 749927003753 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 749927003754 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 749927003755 active pocket/dimerization site; other site 749927003756 active site 749927003757 phosphorylation site [posttranslational modification] 749927003758 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 749927003759 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 749927003760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 749927003761 DNA-binding site [nucleotide binding]; DNA binding site 749927003762 UTRA domain; Region: UTRA; pfam07702 749927003763 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927003764 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927003765 DNA binding site [nucleotide binding] 749927003766 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927003767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927003768 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927003770 binding surface 749927003771 TPR motif; other site 749927003772 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003773 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003774 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927003775 enterobactin exporter EntS; Provisional; Region: PRK10489 749927003776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927003777 putative substrate translocation pore; other site 749927003778 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749927003779 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927003780 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 749927003781 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 749927003782 Walker A/P-loop; other site 749927003783 ATP binding site [chemical binding]; other site 749927003784 Q-loop/lid; other site 749927003785 ABC transporter signature motif; other site 749927003786 Walker B; other site 749927003787 D-loop; other site 749927003788 H-loop/switch region; other site 749927003789 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 749927003790 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 749927003791 Walker A/P-loop; other site 749927003792 ATP binding site [chemical binding]; other site 749927003793 Q-loop/lid; other site 749927003794 ABC transporter signature motif; other site 749927003795 Walker B; other site 749927003796 D-loop; other site 749927003797 H-loop/switch region; other site 749927003798 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 749927003799 TM-ABC transporter signature motif; other site 749927003800 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 749927003801 TM-ABC transporter signature motif; other site 749927003802 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 749927003803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927003804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927003806 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927003807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927003808 active site 749927003809 phosphorylation site [posttranslational modification] 749927003810 intermolecular recognition site; other site 749927003811 dimerization interface [polypeptide binding]; other site 749927003812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927003813 DNA binding residues [nucleotide binding] 749927003814 Putative sensor; Region: Sensor; pfam13796 749927003815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927003816 Histidine kinase; Region: HisKA_3; pfam07730 749927003817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927003818 ATP binding site [chemical binding]; other site 749927003819 Mg2+ binding site [ion binding]; other site 749927003820 G-X-G motif; other site 749927003821 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 749927003822 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 749927003823 Walker A/P-loop; other site 749927003824 ATP binding site [chemical binding]; other site 749927003825 Q-loop/lid; other site 749927003826 ABC transporter signature motif; other site 749927003827 Walker B; other site 749927003828 D-loop; other site 749927003829 H-loop/switch region; other site 749927003830 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 749927003831 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 749927003832 FtsX-like permease family; Region: FtsX; pfam02687 749927003833 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 749927003834 FtsX-like permease family; Region: FtsX; pfam02687 749927003835 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 749927003836 Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs; Region: CE4_SlAXE_like; cd10953 749927003837 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 749927003838 NodB motif; other site 749927003839 active site 749927003840 catalytic site [active] 749927003841 Zn binding site [ion binding]; other site 749927003842 dimer interface [polypeptide binding]; other site 749927003843 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927003844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927003845 Walker A/P-loop; other site 749927003846 ATP binding site [chemical binding]; other site 749927003847 Q-loop/lid; other site 749927003848 ABC transporter signature motif; other site 749927003849 Walker B; other site 749927003850 D-loop; other site 749927003851 H-loop/switch region; other site 749927003852 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927003853 Uncharacterized conserved protein [Function unknown]; Region: COG3391 749927003854 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 749927003855 Phosphoesterase family; Region: Phosphoesterase; pfam04185 749927003856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927003857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927003858 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927003859 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 749927003860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927003861 putative substrate translocation pore; other site 749927003862 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 749927003863 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 749927003864 NAD binding site [chemical binding]; other site 749927003865 catalytic residues [active] 749927003866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927003868 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 749927003869 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 749927003870 Glucose dehydrogenase; Region: glucose_DH; cd08230 749927003871 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927003872 NADP binding site [chemical binding]; other site 749927003873 catalytic Zn binding site [ion binding]; other site 749927003874 structural Zn binding site [ion binding]; other site 749927003875 dimer interface [polypeptide binding]; other site 749927003876 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 749927003877 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927003878 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927003879 putative sugar binding sites [chemical binding]; other site 749927003880 Q-X-W motif; other site 749927003881 Chitin binding domain; Region: Chitin_bind_3; pfam03067 749927003882 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927003883 Protein of unknown function DUF72; Region: DUF72; pfam01904 749927003884 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 749927003885 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 749927003886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 749927003887 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 749927003888 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 749927003889 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927003890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927003891 putative substrate translocation pore; other site 749927003892 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 749927003893 Zn binding site [ion binding]; other site 749927003894 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927003895 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927003896 putative Zn2+ binding site [ion binding]; other site 749927003897 putative DNA binding site [nucleotide binding]; other site 749927003898 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 749927003899 RHS Repeat; Region: RHS_repeat; pfam05593 749927003900 RHS Repeat; Region: RHS_repeat; pfam05593 749927003901 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927003902 RHS Repeat; Region: RHS_repeat; pfam05593 749927003903 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 749927003904 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 749927003905 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 749927003906 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 749927003907 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927003908 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 749927003909 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 749927003910 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 749927003911 DinB superfamily; Region: DinB_2; pfam12867 749927003912 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 749927003913 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927003914 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927003915 putative NAD(P) binding site [chemical binding]; other site 749927003916 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927003917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003918 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927003919 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927003920 putative NAD(P) binding site [chemical binding]; other site 749927003921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927003922 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927003923 salt bridge; other site 749927003924 non-specific DNA binding site [nucleotide binding]; other site 749927003925 sequence-specific DNA binding site [nucleotide binding]; other site 749927003926 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 749927003927 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927003928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927003929 ATP binding site [chemical binding]; other site 749927003930 Mg2+ binding site [ion binding]; other site 749927003931 G-X-G motif; other site 749927003932 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 749927003933 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927003934 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 749927003935 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 749927003936 G1 box; other site 749927003937 GTP/Mg2+ binding site [chemical binding]; other site 749927003938 G2 box; other site 749927003939 Switch I region; other site 749927003940 G3 box; other site 749927003941 Switch II region; other site 749927003942 G5 box; other site 749927003943 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927003944 short chain dehydrogenase; Provisional; Region: PRK06523 749927003945 classical (c) SDRs; Region: SDR_c; cd05233 749927003946 NAD(P) binding site [chemical binding]; other site 749927003947 active site 749927003948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927003949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927003950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 749927003951 dimerization interface [polypeptide binding]; other site 749927003952 short chain dehydrogenase; Provisional; Region: PRK06500 749927003953 classical (c) SDRs; Region: SDR_c; cd05233 749927003954 NAD(P) binding site [chemical binding]; other site 749927003955 active site 749927003956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927003957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003958 hypothetical protein; Provisional; Region: PRK06184 749927003959 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927003960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927003961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003962 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 749927003963 Transposase; Region: HTH_Tnp_1; cl17663 749927003964 putative transposase OrfB; Reviewed; Region: PHA02517 749927003965 HTH-like domain; Region: HTH_21; pfam13276 749927003966 Integrase core domain; Region: rve; pfam00665 749927003967 Integrase core domain; Region: rve_3; pfam13683 749927003968 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 749927003969 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927003970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927003971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927003972 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927003973 active site 749927003974 catalytic tetrad [active] 749927003975 Immunity protein 46; Region: Imm46; pfam15585 749927003976 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927003977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927003978 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927003979 DNA binding residues [nucleotide binding] 749927003980 putative transposase OrfB; Reviewed; Region: PHA02517 749927003981 HTH-like domain; Region: HTH_21; pfam13276 749927003982 Integrase core domain; Region: rve; pfam00665 749927003983 Integrase core domain; Region: rve_3; pfam13683 749927003984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 749927003985 Transposase; Region: HTH_Tnp_1; cl17663 749927003986 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 749927003987 nucleotidyl binding site; other site 749927003988 metal binding site [ion binding]; metal-binding site 749927003989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927003990 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927003992 binding surface 749927003993 TPR motif; other site 749927003994 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927003996 binding surface 749927003997 TPR motif; other site 749927003998 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927003999 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927004000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927004001 putative Zn2+ binding site [ion binding]; other site 749927004002 putative DNA binding site [nucleotide binding]; other site 749927004003 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 749927004004 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927004005 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927004006 DoxX-like family; Region: DoxX_2; pfam13564 749927004007 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927004008 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927004009 putative NAD(P) binding site [chemical binding]; other site 749927004010 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 749927004011 putative active site [active] 749927004012 metal binding site [ion binding]; metal-binding site 749927004013 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 749927004014 active site 749927004015 catalytic residues [active] 749927004016 metal binding site [ion binding]; metal-binding site 749927004017 AMP-binding domain protein; Validated; Region: PRK08315 749927004018 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 749927004019 acyl-activating enzyme (AAE) consensus motif; other site 749927004020 putative AMP binding site [chemical binding]; other site 749927004021 putative active site [active] 749927004022 putative CoA binding site [chemical binding]; other site 749927004023 Predicted acyl esterases [General function prediction only]; Region: COG2936 749927004024 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 749927004025 GAF domain; Region: GAF_2; pfam13185 749927004026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927004027 Histidine kinase; Region: HisKA_3; pfam07730 749927004028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927004029 ATP binding site [chemical binding]; other site 749927004030 Mg2+ binding site [ion binding]; other site 749927004031 G-X-G motif; other site 749927004032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927004033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927004034 active site 749927004035 phosphorylation site [posttranslational modification] 749927004036 intermolecular recognition site; other site 749927004037 dimerization interface [polypeptide binding]; other site 749927004038 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927004039 DNA binding residues [nucleotide binding] 749927004040 dimerization interface [polypeptide binding]; other site 749927004041 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 749927004042 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749927004043 active site 749927004044 Int/Topo IB signature motif; other site 749927004045 DNA binding site [nucleotide binding] 749927004046 Helix-turn-helix domain; Region: HTH_17; cl17695 749927004047 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927004048 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927004049 putative sugar binding sites [chemical binding]; other site 749927004050 Q-X-W motif; other site 749927004051 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 749927004052 ribonuclease Z; Reviewed; Region: PRK00055 749927004053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927004054 active site 749927004055 phosphorylation site [posttranslational modification] 749927004056 intermolecular recognition site; other site 749927004057 dimerization interface [polypeptide binding]; other site 749927004058 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749927004059 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 749927004060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927004061 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 749927004062 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 749927004063 ligand binding site [chemical binding]; other site 749927004064 flexible hinge region; other site 749927004065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927004066 ATP binding site [chemical binding]; other site 749927004067 Mg2+ binding site [ion binding]; other site 749927004068 G-X-G motif; other site 749927004069 Carboxylesterase family; Region: COesterase; pfam00135 749927004070 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 749927004071 substrate binding pocket [chemical binding]; other site 749927004072 catalytic triad [active] 749927004073 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927004074 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 749927004075 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 749927004076 von Willebrand factor type A domain; Region: VWA_2; pfam13519 749927004077 metal ion-dependent adhesion site (MIDAS); other site 749927004078 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 749927004079 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 749927004080 Transposase; Region: DEDD_Tnp_IS110; pfam01548 749927004081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 749927004082 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 749927004083 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 749927004084 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 749927004085 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 749927004086 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 749927004087 Moco binding site; other site 749927004088 metal coordination site [ion binding]; other site 749927004089 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 749927004090 FAD binding pocket [chemical binding]; other site 749927004091 FAD binding motif [chemical binding]; other site 749927004092 phosphate binding motif [ion binding]; other site 749927004093 beta-alpha-beta structure motif; other site 749927004094 NAD binding pocket [chemical binding]; other site 749927004095 Right handed beta helix region; Region: Beta_helix; pfam13229 749927004096 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927004097 Interdomain contacts; other site 749927004098 Cytokine receptor motif; other site 749927004099 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927004100 Interdomain contacts; other site 749927004101 Cytokine receptor motif; other site 749927004102 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927004103 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927004104 DNA binding residues [nucleotide binding] 749927004105 dimerization interface [polypeptide binding]; other site 749927004106 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927004107 nucleotide binding site [chemical binding]; other site 749927004108 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749927004109 G1 box; other site 749927004110 GTP/Mg2+ binding site [chemical binding]; other site 749927004111 G2 box; other site 749927004112 Switch I region; other site 749927004113 G3 box; other site 749927004114 Switch II region; other site 749927004115 G4 box; other site 749927004116 G5 box; other site 749927004117 AAA domain; Region: AAA_17; cl19128 749927004118 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 749927004119 homotrimer interaction site [polypeptide binding]; other site 749927004120 putative active site [active] 749927004121 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927004122 dimerization interface [polypeptide binding]; other site 749927004123 putative DNA binding site [nucleotide binding]; other site 749927004124 putative Zn2+ binding site [ion binding]; other site 749927004125 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 749927004126 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 749927004127 acyl-activating enzyme (AAE) consensus motif; other site 749927004128 putative AMP binding site [chemical binding]; other site 749927004129 putative active site [active] 749927004130 putative CoA binding site [chemical binding]; other site 749927004131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927004132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927004133 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749927004134 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749927004135 catalytic residue [active] 749927004136 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927004137 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 749927004138 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927004139 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927004140 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927004141 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749927004142 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749927004143 substrate binding pocket [chemical binding]; other site 749927004144 membrane-bound complex binding site; other site 749927004145 hinge residues; other site 749927004146 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 749927004147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927004148 dimer interface [polypeptide binding]; other site 749927004149 conserved gate region; other site 749927004150 putative PBP binding loops; other site 749927004151 ABC-ATPase subunit interface; other site 749927004152 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 749927004153 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 749927004154 Walker A/P-loop; other site 749927004155 ATP binding site [chemical binding]; other site 749927004156 Q-loop/lid; other site 749927004157 ABC transporter signature motif; other site 749927004158 Walker B; other site 749927004159 D-loop; other site 749927004160 H-loop/switch region; other site 749927004161 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927004162 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927004163 catalytic residue [active] 749927004164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 749927004165 YheO-like PAS domain; Region: PAS_6; pfam08348 749927004166 HTH domain; Region: HTH_22; pfam13309 749927004167 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927004168 active site 749927004169 TDP-binding site; other site 749927004170 glycosyltransferase, MGT family; Region: MGT; TIGR01426 749927004171 acceptor substrate-binding pocket; other site 749927004172 homodimer interface [polypeptide binding]; other site 749927004173 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927004174 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927004175 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927004176 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927004177 Walker A/P-loop; other site 749927004178 ATP binding site [chemical binding]; other site 749927004179 Q-loop/lid; other site 749927004180 ABC transporter signature motif; other site 749927004181 Walker B; other site 749927004182 D-loop; other site 749927004183 H-loop/switch region; other site 749927004184 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927004185 ABC-2 type transporter; Region: ABC2_membrane; cl17235 749927004186 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927004187 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 749927004188 DNA polymerase IV; Provisional; Region: PRK03348 749927004189 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 749927004190 active site 749927004191 DNA binding site [nucleotide binding] 749927004192 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 749927004193 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927004194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927004195 DNA-binding site [nucleotide binding]; DNA binding site 749927004196 FCD domain; Region: FCD; pfam07729 749927004197 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927004198 TM-ABC transporter signature motif; other site 749927004199 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 749927004200 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927004201 Walker A/P-loop; other site 749927004202 ATP binding site [chemical binding]; other site 749927004203 Q-loop/lid; other site 749927004204 ABC transporter signature motif; other site 749927004205 Walker B; other site 749927004206 D-loop; other site 749927004207 H-loop/switch region; other site 749927004208 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 749927004209 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 749927004210 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 749927004211 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 749927004212 putative active site [active] 749927004213 putative metal binding site [ion binding]; other site 749927004214 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 749927004215 substrate binding pocket [chemical binding]; other site 749927004216 chain length determination region; other site 749927004217 substrate-Mg2+ binding site; other site 749927004218 catalytic residues [active] 749927004219 aspartate-rich region 1; other site 749927004220 active site lid residues [active] 749927004221 aspartate-rich region 2; other site 749927004222 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 749927004223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 749927004224 ligand binding site [chemical binding]; other site 749927004225 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 749927004226 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 749927004227 ligand binding site [chemical binding]; other site 749927004228 flexible hinge region; other site 749927004229 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 749927004230 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 749927004231 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 749927004232 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 749927004233 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 749927004234 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 749927004235 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927004236 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927004237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927004238 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927004239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927004240 binding surface 749927004241 TPR motif; other site 749927004242 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927004243 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927004244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927004245 binding surface 749927004246 TPR motif; other site 749927004247 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927004248 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 749927004249 PhoD-like phosphatase; Region: PhoD; pfam09423 749927004250 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 749927004251 putative active site [active] 749927004252 putative metal binding site [ion binding]; other site 749927004253 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 749927004254 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 749927004255 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 749927004256 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 749927004257 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927004258 sugar binding site [chemical binding]; other site 749927004259 Trehalase; Region: Trehalase; cl17346 749927004260 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 749927004261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927004262 nucleotide binding site [chemical binding]; other site 749927004263 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 749927004264 peptidase domain interface [polypeptide binding]; other site 749927004265 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 749927004266 active site 749927004267 catalytic triad [active] 749927004268 calcium binding site [ion binding]; other site 749927004269 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927004270 Histidine kinase; Region: HisKA_3; pfam07730 749927004271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927004272 ATP binding site [chemical binding]; other site 749927004273 Mg2+ binding site [ion binding]; other site 749927004274 G-X-G motif; other site 749927004275 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 749927004276 Na binding site [ion binding]; other site 749927004277 short chain dehydrogenase; Region: adh_short; pfam00106 749927004278 classical (c) SDRs; Region: SDR_c; cd05233 749927004279 NAD(P) binding site [chemical binding]; other site 749927004280 active site 749927004281 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 749927004282 NMT1-like family; Region: NMT1_2; pfam13379 749927004283 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 749927004284 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 749927004285 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 749927004286 Walker A/P-loop; other site 749927004287 ATP binding site [chemical binding]; other site 749927004288 Q-loop/lid; other site 749927004289 ABC transporter signature motif; other site 749927004290 Walker B; other site 749927004291 D-loop; other site 749927004292 H-loop/switch region; other site 749927004293 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749927004294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927004295 dimer interface [polypeptide binding]; other site 749927004296 conserved gate region; other site 749927004297 putative PBP binding loops; other site 749927004298 ABC-ATPase subunit interface; other site 749927004299 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 749927004300 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 749927004301 Strictosidine synthase; Region: Str_synth; cl19733 749927004302 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 749927004303 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 749927004304 ATP binding site [chemical binding]; other site 749927004305 Mg++ binding site [ion binding]; other site 749927004306 motif III; other site 749927004307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927004308 nucleotide binding region [chemical binding]; other site 749927004309 ATP-binding site [chemical binding]; other site 749927004310 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927004311 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 749927004312 active site 749927004313 Domain of unknown function (DUF385); Region: DUF385; cl04387 749927004314 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 749927004315 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 749927004316 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 749927004317 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 749927004318 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 749927004319 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 749927004320 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 749927004321 RNA binding site [nucleotide binding]; other site 749927004322 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 749927004323 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 749927004324 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 749927004325 putative active site [active] 749927004326 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 749927004327 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927004328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927004329 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 749927004330 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 749927004331 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 749927004332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 749927004333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927004334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927004335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927004336 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749927004337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927004338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927004339 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927004340 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 749927004341 acyl-activating enzyme (AAE) consensus motif; other site 749927004342 AMP binding site [chemical binding]; other site 749927004343 active site 749927004344 CoA binding site [chemical binding]; other site 749927004345 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 749927004346 CoenzymeA binding site [chemical binding]; other site 749927004347 subunit interaction site [polypeptide binding]; other site 749927004348 PHB binding site; other site 749927004349 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 749927004350 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 749927004351 substrate binding site [chemical binding]; other site 749927004352 dimer interface [polypeptide binding]; other site 749927004353 NADP binding site [chemical binding]; other site 749927004354 catalytic residues [active] 749927004355 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 749927004356 active site 2 [active] 749927004357 active site 1 [active] 749927004358 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 749927004359 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 749927004360 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 749927004361 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 749927004362 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 749927004363 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 749927004364 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 749927004365 FAD binding pocket [chemical binding]; other site 749927004366 FAD binding motif [chemical binding]; other site 749927004367 phosphate binding motif [ion binding]; other site 749927004368 beta-alpha-beta structure motif; other site 749927004369 NAD(p) ribose binding residues [chemical binding]; other site 749927004370 NAD binding pocket [chemical binding]; other site 749927004371 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 749927004372 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927004373 catalytic loop [active] 749927004374 iron binding site [ion binding]; other site 749927004375 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927004376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927004377 non-specific DNA binding site [nucleotide binding]; other site 749927004378 salt bridge; other site 749927004379 sequence-specific DNA binding site [nucleotide binding]; other site 749927004380 cyclase homology domain; Region: CHD; cd07302 749927004381 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 749927004382 nucleotidyl binding site; other site 749927004383 metal binding site [ion binding]; metal-binding site 749927004384 dimer interface [polypeptide binding]; other site 749927004385 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749927004386 Ligand Binding Site [chemical binding]; other site 749927004387 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 749927004388 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 749927004389 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927004390 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 749927004391 NAD(P) binding site [chemical binding]; other site 749927004392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927004393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927004394 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 749927004395 dimer interface [polypeptide binding]; other site 749927004396 substrate binding site [chemical binding]; other site 749927004397 metal binding site [ion binding]; metal-binding site 749927004398 putative acyltransferase; Provisional; Region: PRK05790 749927004399 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927004400 dimer interface [polypeptide binding]; other site 749927004401 active site 749927004402 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 749927004403 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 749927004404 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 749927004405 Walker A; other site 749927004406 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749927004407 G4 box; other site 749927004408 G5 box; other site 749927004409 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 749927004410 active site 749927004411 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 749927004412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 749927004413 DNA-binding site [nucleotide binding]; DNA binding site 749927004414 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927004415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927004416 homodimer interface [polypeptide binding]; other site 749927004417 catalytic residue [active] 749927004418 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927004419 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 749927004420 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 749927004421 tetramer interface [polypeptide binding]; other site 749927004422 active site 749927004423 Mg2+/Mn2+ binding site [ion binding]; other site 749927004424 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 749927004425 Na binding site [ion binding]; other site 749927004426 Protein of unknown function, DUF485; Region: DUF485; pfam04341 749927004427 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 749927004428 Na binding site [ion binding]; other site 749927004429 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 749927004430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927004431 active site 749927004432 phosphorylation site [posttranslational modification] 749927004433 intermolecular recognition site; other site 749927004434 dimerization interface [polypeptide binding]; other site 749927004435 LytTr DNA-binding domain; Region: LytTR; smart00850 749927004436 Histidine kinase; Region: His_kinase; pfam06580 749927004437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927004438 ATP binding site [chemical binding]; other site 749927004439 Mg2+ binding site [ion binding]; other site 749927004440 G-X-G motif; other site 749927004441 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 749927004442 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 749927004443 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 749927004444 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927004445 TM-ABC transporter signature motif; other site 749927004446 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 749927004447 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927004448 Walker A/P-loop; other site 749927004449 ATP binding site [chemical binding]; other site 749927004450 Q-loop/lid; other site 749927004451 ABC transporter signature motif; other site 749927004452 Walker B; other site 749927004453 D-loop; other site 749927004454 H-loop/switch region; other site 749927004455 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 749927004456 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 749927004457 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927004458 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927004459 DNA binding site [nucleotide binding] 749927004460 domain linker motif; other site 749927004461 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927004462 dimerization interface [polypeptide binding]; other site 749927004463 ligand binding site [chemical binding]; other site 749927004464 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 749927004465 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 749927004466 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 749927004467 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 749927004468 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 749927004469 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927004470 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927004471 Domain of unknown function DUF77; Region: DUF77; pfam01910 749927004472 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632 749927004473 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 749927004474 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 749927004475 Tetratricopeptide repeat; Region: TPR_20; pfam14561 749927004476 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 749927004477 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 749927004478 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 749927004479 putative homodimer interface [polypeptide binding]; other site 749927004480 putative active site pocket [active] 749927004481 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 749927004482 Fusaric acid resistance protein family; Region: FUSC; pfam04632 749927004483 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 749927004484 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 749927004485 active site residue [active] 749927004486 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 749927004487 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 749927004488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927004489 Walker A/P-loop; other site 749927004490 ATP binding site [chemical binding]; other site 749927004491 Q-loop/lid; other site 749927004492 ABC transporter signature motif; other site 749927004493 Walker B; other site 749927004494 D-loop; other site 749927004495 H-loop/switch region; other site 749927004496 enoyl-CoA hydratase; Provisional; Region: PRK08138 749927004497 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927004498 substrate binding site [chemical binding]; other site 749927004499 oxyanion hole (OAH) forming residues; other site 749927004500 trimer interface [polypeptide binding]; other site 749927004501 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749927004502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927004503 S-adenosylmethionine binding site [chemical binding]; other site 749927004504 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 749927004505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 749927004506 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927004507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927004508 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 749927004509 dimerization interface [polypeptide binding]; other site 749927004510 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 749927004511 active site 749927004512 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 749927004513 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 749927004514 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 749927004515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927004516 DNA-binding site [nucleotide binding]; DNA binding site 749927004517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927004518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927004519 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927004520 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927004521 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927004522 hypothetical protein; Provisional; Region: PRK08244 749927004523 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927004524 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927004525 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927004526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927004527 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 749927004528 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927004529 SCP-2 sterol transfer family; Region: SCP2; cl01225 749927004530 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927004531 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927004532 active site 749927004533 catalytic tetrad [active] 749927004534 hypothetical protein; Provisional; Region: PRK06834 749927004535 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927004536 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 749927004537 NlpC/P60 family; Region: NLPC_P60; pfam00877 749927004538 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 749927004539 active site 749927004540 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 749927004541 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 749927004542 trimer interface [polypeptide binding]; other site 749927004543 active site 749927004544 substrate binding site [chemical binding]; other site 749927004545 CoA binding site [chemical binding]; other site 749927004546 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 749927004547 threonine dehydratase; Validated; Region: PRK08639 749927004548 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 749927004549 tetramer interface [polypeptide binding]; other site 749927004550 catalytic residue [active] 749927004551 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 749927004552 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927004553 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927004554 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927004555 DNA binding residues [nucleotide binding] 749927004556 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927004557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927004558 non-specific DNA binding site [nucleotide binding]; other site 749927004559 salt bridge; other site 749927004560 sequence-specific DNA binding site [nucleotide binding]; other site 749927004561 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 749927004562 Domain of unknown function (DUF955); Region: DUF955; pfam06114 749927004563 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 749927004564 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 749927004565 tetramer interface [polypeptide binding]; other site 749927004566 active site 749927004567 Mg2+/Mn2+ binding site [ion binding]; other site 749927004568 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 749927004569 active site 749927004570 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 749927004571 PA/protease or protease-like domain interface [polypeptide binding]; other site 749927004572 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 749927004573 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927004574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927004575 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927004576 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927004577 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 749927004578 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927004579 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927004580 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927004581 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 749927004582 catalytic residues [active] 749927004583 dimer interface [polypeptide binding]; other site 749927004584 Uncharacterized conserved protein [Function unknown]; Region: COG1543 749927004585 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 749927004586 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 749927004587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927004588 S-adenosylmethionine binding site [chemical binding]; other site 749927004589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 749927004590 EDD domain protein, DegV family; Region: DegV; TIGR00762 749927004591 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 749927004592 Ligand binding site [chemical binding]; other site 749927004593 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 749927004594 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 749927004595 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 749927004596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 749927004597 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 749927004598 putative acyl-acceptor binding pocket; other site 749927004599 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927004600 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927004601 putative NAD(P) binding site [chemical binding]; other site 749927004602 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927004603 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927004604 DNA binding residues [nucleotide binding] 749927004605 dimerization interface [polypeptide binding]; other site 749927004606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927004607 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927004608 putative substrate translocation pore; other site 749927004609 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 749927004610 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 749927004611 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927004612 catalytic residue [active] 749927004613 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 749927004614 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 749927004615 Ligand Binding Site [chemical binding]; other site 749927004616 Domain of unknown function (DUF222); Region: DUF222; pfam02720 749927004617 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927004618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927004619 Coenzyme A binding pocket [chemical binding]; other site 749927004620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927004621 Coenzyme A binding pocket [chemical binding]; other site 749927004622 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 749927004623 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 749927004624 Scramblase; Region: Scramblase; pfam03803 749927004625 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 749927004626 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 749927004627 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 749927004628 nucleotide binding pocket [chemical binding]; other site 749927004629 K-X-D-G motif; other site 749927004630 catalytic site [active] 749927004631 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 749927004632 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 749927004633 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 749927004634 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 749927004635 Dimer interface [polypeptide binding]; other site 749927004636 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 749927004637 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927004638 Coenzyme A binding pocket [chemical binding]; other site 749927004639 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 749927004640 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 749927004641 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 749927004642 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 749927004643 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 749927004644 GatB domain; Region: GatB_Yqey; smart00845 749927004645 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927004646 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927004647 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927004648 Methane oxygenase PmoA; Region: PmoA; pfam14100 749927004649 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 749927004650 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927004651 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927004652 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 749927004653 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 749927004654 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 749927004655 putative ligand binding site [chemical binding]; other site 749927004656 putative NAD binding site [chemical binding]; other site 749927004657 catalytic site [active] 749927004658 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 749927004659 Bacterial PH domain; Region: bPH_6; pfam10756 749927004660 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 749927004661 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749927004662 PYR/PP interface [polypeptide binding]; other site 749927004663 dimer interface [polypeptide binding]; other site 749927004664 TPP binding site [chemical binding]; other site 749927004665 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927004666 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 749927004667 TPP-binding site [chemical binding]; other site 749927004668 dimer interface [polypeptide binding]; other site 749927004669 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 749927004670 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 749927004671 putative valine binding site [chemical binding]; other site 749927004672 dimer interface [polypeptide binding]; other site 749927004673 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 749927004674 ketol-acid reductoisomerase; Provisional; Region: PRK05479 749927004675 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 749927004676 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 749927004677 Domain of unknown function (DUF397); Region: DUF397; pfam04149 749927004678 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 749927004679 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927004680 replicative DNA helicase; Provisional; Region: PRK05973 749927004681 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 749927004682 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 749927004683 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 749927004684 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 749927004685 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927004686 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927004687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927004688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927004689 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 749927004690 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 749927004691 ligand binding site [chemical binding]; other site 749927004692 NAD binding site [chemical binding]; other site 749927004693 dimerization interface [polypeptide binding]; other site 749927004694 catalytic site [active] 749927004695 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 749927004696 putative L-serine binding site [chemical binding]; other site 749927004697 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 749927004698 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 749927004699 Subtilase family; Region: Peptidase_S8; pfam00082 749927004700 catalytic triad [active] 749927004701 putative active site [active] 749927004702 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 749927004703 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 749927004704 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 749927004705 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 749927004706 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 749927004707 active site 749927004708 catalytic residues [active] 749927004709 metal binding site [ion binding]; metal-binding site 749927004710 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 749927004711 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 749927004712 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 749927004713 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 749927004714 hypothetical protein; Provisional; Region: PRK06185 749927004715 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927004716 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 749927004717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927004718 motif II; other site 749927004719 histone-like DNA-binding protein HU; Region: HU; cd13831 749927004720 dimer interface [polypeptide binding]; other site 749927004721 DNA binding site [nucleotide binding] 749927004722 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 749927004723 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927004724 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927004725 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927004726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927004727 binding surface 749927004728 TPR motif; other site 749927004729 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927004730 Helix-turn-helix domain; Region: HTH_31; pfam13560 749927004731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927004732 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 749927004733 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 749927004734 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927004735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927004736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927004737 Lsr2; Region: Lsr2; pfam11774 749927004738 histone-like DNA-binding protein HU; Region: HU; cd13831 749927004739 dimer interface [polypeptide binding]; other site 749927004740 DNA binding site [nucleotide binding] 749927004741 HerA helicase [Replication, recombination, and repair]; Region: COG0433 749927004742 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 749927004743 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 749927004744 active site 749927004745 metal binding site [ion binding]; metal-binding site 749927004746 DNA binding site [nucleotide binding] 749927004747 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 749927004748 potential frameshift: common BLAST hit: gi|258652591|ref|YP_003201747.1| exonuclease SbcC 749927004749 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 749927004750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927004751 Walker A/P-loop; other site 749927004752 ATP binding site [chemical binding]; other site 749927004753 Q-loop/lid; other site 749927004754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927004755 ABC transporter signature motif; other site 749927004756 Walker B; other site 749927004757 D-loop; other site 749927004758 H-loop/switch region; other site 749927004759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 749927004760 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 749927004761 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 749927004762 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 749927004763 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 749927004764 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 749927004765 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927004766 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927004767 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927004768 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 749927004769 substrate binding site [chemical binding]; other site 749927004770 ligand binding site [chemical binding]; other site 749927004771 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 749927004772 substrate binding site [chemical binding]; other site 749927004773 DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cl00257 749927004774 DNA binding site [nucleotide binding] 749927004775 dimer interface [polypeptide binding]; other site 749927004776 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927004777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927004778 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927004779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927004780 binding surface 749927004781 TPR motif; other site 749927004782 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927004783 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 749927004784 active site 749927004785 Ap6A binding site [chemical binding]; other site 749927004786 nudix motif; other site 749927004787 metal binding site [ion binding]; metal-binding site 749927004788 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927004789 catalytic core [active] 749927004790 Family of unknown function (DUF566); Region: DUF566; pfam04484 749927004791 polyphosphate kinase; Provisional; Region: PRK05443 749927004792 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 749927004793 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 749927004794 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 749927004795 putative domain interface [polypeptide binding]; other site 749927004796 putative active site [active] 749927004797 catalytic site [active] 749927004798 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 749927004799 putative domain interface [polypeptide binding]; other site 749927004800 putative active site [active] 749927004801 catalytic site [active] 749927004802 Guanylyl transferase CofC like; Region: CofC; cl17472 749927004803 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 749927004804 putative acyl-acceptor binding pocket; other site 749927004805 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 749927004806 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 749927004807 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 749927004808 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 749927004809 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 749927004810 active site 749927004811 homotetramer interface [polypeptide binding]; other site 749927004812 homodimer interface [polypeptide binding]; other site 749927004813 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927004814 active site 749927004815 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 749927004816 FMN-binding domain; Region: FMN_bind; cl01081 749927004817 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 749927004818 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 749927004819 FAD binding pocket [chemical binding]; other site 749927004820 FAD binding motif [chemical binding]; other site 749927004821 phosphate binding motif [ion binding]; other site 749927004822 beta-alpha-beta structure motif; other site 749927004823 NAD binding pocket [chemical binding]; other site 749927004824 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927004825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927004826 active site 749927004827 phosphorylation site [posttranslational modification] 749927004828 intermolecular recognition site; other site 749927004829 dimerization interface [polypeptide binding]; other site 749927004830 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927004831 DNA binding site [nucleotide binding] 749927004832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927004833 HAMP domain; Region: HAMP; pfam00672 749927004834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927004835 dimer interface [polypeptide binding]; other site 749927004836 phosphorylation site [posttranslational modification] 749927004837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927004838 ATP binding site [chemical binding]; other site 749927004839 Mg2+ binding site [ion binding]; other site 749927004840 G-X-G motif; other site 749927004841 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 749927004842 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 749927004843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927004844 DNA-binding site [nucleotide binding]; DNA binding site 749927004845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927004846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927004847 homodimer interface [polypeptide binding]; other site 749927004848 catalytic residue [active] 749927004849 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 749927004850 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 749927004851 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 749927004852 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 749927004853 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927004854 AsnC family; Region: AsnC_trans_reg; pfam01037 749927004855 thiamine monophosphate kinase; Provisional; Region: PRK05731 749927004856 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 749927004857 ATP binding site [chemical binding]; other site 749927004858 dimerization interface [polypeptide binding]; other site 749927004859 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927004860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927004861 Coenzyme A binding pocket [chemical binding]; other site 749927004862 alpha-galactosidase; Region: PLN02808; cl17638 749927004863 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 749927004864 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 749927004865 trimer interface [polypeptide binding]; other site 749927004866 putative metal binding site [ion binding]; other site 749927004867 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 749927004868 ligand binding site [chemical binding]; other site 749927004869 active site 749927004870 UGI interface [polypeptide binding]; other site 749927004871 catalytic site [active] 749927004872 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927004873 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 749927004874 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 749927004875 DAK2 domain; Region: Dak2; pfam02734 749927004876 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 749927004877 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 749927004878 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 749927004879 generic binding surface II; other site 749927004880 ssDNA binding site; other site 749927004881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927004882 ATP binding site [chemical binding]; other site 749927004883 putative Mg++ binding site [ion binding]; other site 749927004884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927004885 nucleotide binding region [chemical binding]; other site 749927004886 ATP-binding site [chemical binding]; other site 749927004887 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927004888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927004889 Coenzyme A binding pocket [chemical binding]; other site 749927004890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927004891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927004892 Erythromycin esterase; Region: Erythro_esteras; cl17110 749927004893 Caspase domain; Region: Peptidase_C14; pfam00656 749927004894 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 749927004895 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 749927004896 calcium binding site 2 [ion binding]; other site 749927004897 Subtilase family; Region: Peptidase_S8; pfam00082 749927004898 active site 749927004899 catalytic triad [active] 749927004900 calcium binding site 1 [ion binding]; other site 749927004901 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 749927004902 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 749927004903 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 749927004904 Transposase [DNA replication, recombination, and repair]; Region: COG5433 749927004905 Potato inhibitor I family; Region: potato_inhibit; pfam00280 749927004906 pyruvate carboxylase; Reviewed; Region: PRK12999 749927004907 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749927004908 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927004909 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 749927004910 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 749927004911 active site 749927004912 catalytic residues [active] 749927004913 metal binding site [ion binding]; metal-binding site 749927004914 homodimer binding site [polypeptide binding]; other site 749927004915 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 749927004916 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 749927004917 carboxyltransferase (CT) interaction site; other site 749927004918 biotinylation site [posttranslational modification]; other site 749927004919 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 749927004920 active site 749927004921 Mn binding site [ion binding]; other site 749927004922 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927004923 DNA-binding site [nucleotide binding]; DNA binding site 749927004924 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927004925 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 749927004926 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 749927004927 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 749927004928 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 749927004929 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 749927004930 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927004931 mce related protein; Region: MCE; pfam02470 749927004932 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927004933 mce related protein; Region: MCE; pfam02470 749927004934 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927004935 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927004936 mce related protein; Region: MCE; pfam02470 749927004937 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927004938 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927004939 mce related protein; Region: MCE; pfam02470 749927004940 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927004941 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927004942 mce related protein; Region: MCE; pfam02470 749927004943 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927004944 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927004945 mce related protein; Region: MCE; pfam02470 749927004946 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927004947 Permease; Region: Permease; pfam02405 749927004948 Permease; Region: Permease; pfam02405 749927004949 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 749927004950 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 749927004951 hypothetical protein; Provisional; Region: PRK08244 749927004952 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927004953 Clp amino terminal domain; Region: Clp_N; pfam02861 749927004954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927004955 non-specific DNA binding site [nucleotide binding]; other site 749927004956 salt bridge; other site 749927004957 sequence-specific DNA binding site [nucleotide binding]; other site 749927004958 AAA ATPase domain; Region: AAA_16; pfam13191 749927004959 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 749927004960 structural tetrad; other site 749927004961 FOG: WD40 repeat [General function prediction only]; Region: COG2319 749927004962 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 749927004963 structural tetrad; other site 749927004964 WD40 repeats; Region: WD40; smart00320 749927004965 WD domain, G-beta repeat; Region: WD40; pfam00400 749927004966 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 749927004967 Part of AAA domain; Region: AAA_19; pfam13245 749927004968 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 749927004969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927004970 S-adenosylmethionine binding site [chemical binding]; other site 749927004971 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 749927004972 active site 749927004973 (T/H)XGH motif; other site 749927004974 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 749927004975 active site 749927004976 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 749927004977 active site 749927004978 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927004979 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927004980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927004981 DNA binding residues [nucleotide binding] 749927004982 DGC domain; Region: DGC; cl01742 749927004983 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 749927004984 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 749927004985 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 749927004986 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 749927004987 ribonuclease III; Reviewed; Region: rnc; PRK00102 749927004988 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 749927004989 dimerization interface [polypeptide binding]; other site 749927004990 active site 749927004991 metal binding site [ion binding]; metal-binding site 749927004992 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 749927004993 dsRNA binding site [nucleotide binding]; other site 749927004994 Chondroitinase B; Region: Chondroitinas_B; pfam14592 749927004995 Right handed beta helix region; Region: Beta_helix; pfam13229 749927004996 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 749927004997 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 749927004998 DNA binding site [nucleotide binding] 749927004999 catalytic residue [active] 749927005000 H2TH interface [polypeptide binding]; other site 749927005001 putative catalytic residues [active] 749927005002 turnover-facilitating residue; other site 749927005003 intercalation triad [nucleotide binding]; other site 749927005004 8OG recognition residue [nucleotide binding]; other site 749927005005 putative reading head residues; other site 749927005006 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 749927005007 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 749927005008 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927005009 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 749927005010 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927005011 Predicted membrane protein [Function unknown]; Region: COG4709 749927005012 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927005013 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927005014 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927005015 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 749927005016 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 749927005017 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 749927005018 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 749927005019 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 749927005020 catalytic triad [active] 749927005021 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 749927005022 NAD(P) binding site [chemical binding]; other site 749927005023 catalytic residues [active] 749927005024 short chain dehydrogenase; Provisional; Region: PRK06057 749927005025 classical (c) SDRs; Region: SDR_c; cd05233 749927005026 NAD(P) binding site [chemical binding]; other site 749927005027 active site 749927005028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927005029 non-specific DNA binding site [nucleotide binding]; other site 749927005030 salt bridge; other site 749927005031 sequence-specific DNA binding site [nucleotide binding]; other site 749927005032 glycine dehydrogenase; Provisional; Region: PRK05367 749927005033 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 749927005034 tetramer interface [polypeptide binding]; other site 749927005035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927005036 catalytic residue [active] 749927005037 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 749927005038 tetramer interface [polypeptide binding]; other site 749927005039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927005040 catalytic residue [active] 749927005041 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 749927005042 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 749927005043 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 749927005044 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 749927005045 lipoyl attachment site [posttranslational modification]; other site 749927005046 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 749927005047 dimer interface [polypeptide binding]; other site 749927005048 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 749927005049 active site 749927005050 glycine-pyridoxal phosphate binding site [chemical binding]; other site 749927005051 folate binding site [chemical binding]; other site 749927005052 lipoyl synthase; Provisional; Region: PRK05481 749927005053 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927005054 FeS/SAM binding site; other site 749927005055 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 749927005056 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 749927005057 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 749927005058 Alpha-helical domain 2; Region: alpha-hel2; cl19908 749927005059 Protein of unknown function (DUF433); Region: DUF433; cl01030 749927005060 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927005061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927005062 DNA-binding site [nucleotide binding]; DNA binding site 749927005063 FCD domain; Region: FCD; pfam07729 749927005064 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 749927005065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927005066 S-adenosylmethionine binding site [chemical binding]; other site 749927005067 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 749927005068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927005069 DNA-binding site [nucleotide binding]; DNA binding site 749927005070 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927005071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927005072 homodimer interface [polypeptide binding]; other site 749927005073 catalytic residue [active] 749927005074 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927005075 Pilus assembly protein, PilP; Region: PilP; cl19831 749927005076 short chain dehydrogenase; Provisional; Region: PRK07201 749927005077 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 749927005078 putative NAD(P) binding site [chemical binding]; other site 749927005079 active site 749927005080 putative substrate binding site [chemical binding]; other site 749927005081 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 749927005082 classical (c) SDRs; Region: SDR_c; cd05233 749927005083 NAD(P) binding site [chemical binding]; other site 749927005084 NAD binding site [chemical binding]; other site 749927005085 active site 749927005086 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 749927005087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927005088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927005089 Reductase C-terminal; Region: Reductase_C; pfam14759 749927005090 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 749927005091 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 749927005092 DNA binding residues [nucleotide binding] 749927005093 dimer interface [polypeptide binding]; other site 749927005094 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 749927005095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927005096 putative substrate translocation pore; other site 749927005097 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 749927005098 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 749927005099 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 749927005100 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 749927005101 metal binding site [ion binding]; metal-binding site 749927005102 substrate binding pocket [chemical binding]; other site 749927005103 short chain dehydrogenase; Provisional; Region: PRK06138 749927005104 classical (c) SDRs; Region: SDR_c; cd05233 749927005105 NAD(P) binding site [chemical binding]; other site 749927005106 active site 749927005107 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 749927005108 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 749927005109 ligand binding site [chemical binding]; other site 749927005110 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 749927005111 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927005112 Walker A/P-loop; other site 749927005113 ATP binding site [chemical binding]; other site 749927005114 Q-loop/lid; other site 749927005115 ABC transporter signature motif; other site 749927005116 Walker B; other site 749927005117 D-loop; other site 749927005118 H-loop/switch region; other site 749927005119 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 749927005120 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927005121 TM-ABC transporter signature motif; other site 749927005122 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927005123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927005124 DNA-binding site [nucleotide binding]; DNA binding site 749927005125 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 749927005126 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927005127 active site 749927005128 catalytic tetrad [active] 749927005129 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927005130 active site 749927005131 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 749927005132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927005133 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927005134 DNA binding residues [nucleotide binding] 749927005135 Domain of unknown function (DUF202); Region: DUF202; pfam02656 749927005136 Domain of unknown function (DUF202); Region: DUF202; cl09954 749927005137 GtrA-like protein; Region: GtrA; pfam04138 749927005138 transcription termination factor Rho; Provisional; Region: PRK12678 749927005139 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 749927005140 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 749927005141 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 749927005142 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 749927005143 dimerization interface [polypeptide binding]; other site 749927005144 ligand binding site [chemical binding]; other site 749927005145 NADP binding site [chemical binding]; other site 749927005146 catalytic site [active] 749927005147 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 749927005148 Melibiase; Region: Melibiase; pfam02065 749927005149 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927005150 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927005151 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927005152 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927005153 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927005154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927005155 dimer interface [polypeptide binding]; other site 749927005156 conserved gate region; other site 749927005157 putative PBP binding loops; other site 749927005158 ABC-ATPase subunit interface; other site 749927005159 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927005160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 749927005161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927005162 dimer interface [polypeptide binding]; other site 749927005163 conserved gate region; other site 749927005164 putative PBP binding loops; other site 749927005165 ABC-ATPase subunit interface; other site 749927005166 alpha-galactosidase; Region: PLN02808; cl17638 749927005167 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 749927005168 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 749927005169 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 749927005170 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927005171 dimer interface [polypeptide binding]; other site 749927005172 active site 749927005173 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 749927005174 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 749927005175 active site 749927005176 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 749927005177 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 749927005178 heterodimer interface [polypeptide binding]; other site 749927005179 active site 749927005180 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 749927005181 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927005182 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927005183 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 749927005184 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 749927005185 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927005186 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 749927005187 metal-binding site 749927005188 MoxR-like ATPases [General function prediction only]; Region: COG0714 749927005189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927005190 Walker A motif; other site 749927005191 ATP binding site [chemical binding]; other site 749927005192 Walker B motif; other site 749927005193 arginine finger; other site 749927005194 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 749927005195 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 749927005196 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 749927005197 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 749927005198 metal ion-dependent adhesion site (MIDAS); other site 749927005199 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 749927005200 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 749927005201 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 749927005202 XdhC Rossmann domain; Region: XdhC_C; pfam13478 749927005203 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 749927005204 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927005205 catalytic loop [active] 749927005206 iron binding site [ion binding]; other site 749927005207 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 749927005208 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 749927005209 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 749927005210 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 749927005211 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 749927005212 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 749927005213 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 749927005214 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 749927005215 putative hydrophobic ligand binding site [chemical binding]; other site 749927005216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927005217 metal binding site [ion binding]; metal-binding site 749927005218 active site 749927005219 I-site; other site 749927005220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 749927005221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 749927005222 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927005223 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927005224 active site 749927005225 catalytic tetrad [active] 749927005226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927005227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927005228 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927005229 sugar binding site [chemical binding]; other site 749927005230 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927005231 Interdomain contacts; other site 749927005232 Cytokine receptor motif; other site 749927005233 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927005234 active site 749927005235 metal binding site [ion binding]; metal-binding site 749927005236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927005237 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927005238 putative substrate translocation pore; other site 749927005239 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 749927005240 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 749927005241 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749927005242 PYR/PP interface [polypeptide binding]; other site 749927005243 dimer interface [polypeptide binding]; other site 749927005244 TPP binding site [chemical binding]; other site 749927005245 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927005246 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 749927005247 TPP-binding site [chemical binding]; other site 749927005248 KduI/IolB family; Region: KduI; pfam04962 749927005249 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 749927005250 substrate binding site [chemical binding]; other site 749927005251 ATP binding site [chemical binding]; other site 749927005252 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 749927005253 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927005254 Walker A/P-loop; other site 749927005255 ATP binding site [chemical binding]; other site 749927005256 Q-loop/lid; other site 749927005257 ABC transporter signature motif; other site 749927005258 Walker B; other site 749927005259 D-loop; other site 749927005260 H-loop/switch region; other site 749927005261 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927005262 TM-ABC transporter signature motif; other site 749927005263 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 749927005264 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 749927005265 putative ligand binding site [chemical binding]; other site 749927005266 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927005267 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 749927005268 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927005269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927005270 DNA binding site [nucleotide binding] 749927005271 domain linker motif; other site 749927005272 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927005273 dimerization interface [polypeptide binding]; other site 749927005274 ligand binding site [chemical binding]; other site 749927005275 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927005276 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927005277 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927005278 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 749927005279 active site 749927005280 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 749927005281 dimer interface [polypeptide binding]; other site 749927005282 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 749927005283 Ligand Binding Site [chemical binding]; other site 749927005284 Molecular Tunnel; other site 749927005285 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 749927005286 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 749927005287 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 749927005288 Soluble P-type ATPase [General function prediction only]; Region: COG4087 749927005289 K+-transporting ATPase, c chain; Region: KdpC; cl00944 749927005290 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 749927005291 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 749927005292 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 749927005293 Ligand Binding Site [chemical binding]; other site 749927005294 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 749927005295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927005296 dimer interface [polypeptide binding]; other site 749927005297 phosphorylation site [posttranslational modification] 749927005298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927005299 ATP binding site [chemical binding]; other site 749927005300 Mg2+ binding site [ion binding]; other site 749927005301 G-X-G motif; other site 749927005302 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 749927005303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927005304 active site 749927005305 phosphorylation site [posttranslational modification] 749927005306 intermolecular recognition site; other site 749927005307 dimerization interface [polypeptide binding]; other site 749927005308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927005309 DNA binding site [nucleotide binding] 749927005310 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927005311 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927005312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927005313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927005314 Acylphosphatase; Region: Acylphosphatase; cl00551 749927005315 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 749927005316 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 749927005317 Walker A/P-loop; other site 749927005318 ATP binding site [chemical binding]; other site 749927005319 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 749927005320 Predicted coiled-coil domain-containing protein; Region: KLRAQ; pfam10205 749927005321 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 749927005322 ABC transporter signature motif; other site 749927005323 Walker B; other site 749927005324 D-loop; other site 749927005325 H-loop/switch region; other site 749927005326 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 749927005327 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 749927005328 Na binding site [ion binding]; other site 749927005329 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 749927005330 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 749927005331 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 749927005332 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 749927005333 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 749927005334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927005335 Coenzyme A binding pocket [chemical binding]; other site 749927005336 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927005337 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927005338 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927005339 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 749927005340 active site 749927005341 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 749927005342 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 749927005343 active site 749927005344 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 749927005345 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 749927005346 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927005347 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927005348 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 749927005349 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927005350 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 749927005351 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 749927005352 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 749927005353 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 749927005354 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927005355 catalytic loop [active] 749927005356 iron binding site [ion binding]; other site 749927005357 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 749927005358 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 749927005359 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 749927005360 active site 749927005361 putative substrate binding pocket [chemical binding]; other site 749927005362 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 749927005363 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 749927005364 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 749927005365 alpha-galactosidase; Region: PLN02808; cl17638 749927005366 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927005367 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927005368 putative sugar binding sites [chemical binding]; other site 749927005369 Q-X-W motif; other site 749927005370 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927005371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927005372 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 749927005373 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 749927005374 urate oxidase; Region: urate_oxi; TIGR03383 749927005375 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 749927005376 active site 749927005377 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 749927005378 active site 749927005379 homotetramer interface [polypeptide binding]; other site 749927005380 putative OHCU decarboxylase; Provisional; Region: PRK13798 749927005381 Domain of unknown function DUF77; Region: DUF77; cl00307 749927005382 HTH domain; Region: HTH_22; pfam13309 749927005383 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927005384 allantoinase; Region: allantoinase; TIGR03178 749927005385 active site 749927005386 allantoicase; Provisional; Region: PRK13257 749927005387 Allantoicase repeat; Region: Allantoicase; pfam03561 749927005388 Allantoicase repeat; Region: Allantoicase; pfam03561 749927005389 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 749927005390 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 749927005391 homodimer interface [polypeptide binding]; other site 749927005392 substrate-cofactor binding pocket; other site 749927005393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927005394 catalytic residue [active] 749927005395 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 749927005396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927005397 NAD(P) binding site [chemical binding]; other site 749927005398 active site 749927005399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927005400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927005401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927005402 dimerization interface [polypeptide binding]; other site 749927005403 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 749927005404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927005405 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927005406 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927005407 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 749927005408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927005409 S-adenosylmethionine binding site [chemical binding]; other site 749927005410 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 749927005411 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 749927005412 PII uridylyl-transferase; Provisional; Region: PRK03381 749927005413 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 749927005414 metal binding triad; other site 749927005415 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 749927005416 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 749927005417 Zn2+ binding site [ion binding]; other site 749927005418 Mg2+ binding site [ion binding]; other site 749927005419 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 749927005420 hypothetical protein; Provisional; Region: PRK06834 749927005421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927005422 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 749927005423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927005424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927005425 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927005426 metal binding site [ion binding]; metal-binding site 749927005427 active site 749927005428 I-site; other site 749927005429 short chain dehydrogenase; Provisional; Region: PRK06172 749927005430 classical (c) SDRs; Region: SDR_c; cd05233 749927005431 NAD(P) binding site [chemical binding]; other site 749927005432 active site 749927005433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927005434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927005435 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 749927005436 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 749927005437 heterodimer interface [polypeptide binding]; other site 749927005438 DNA binding site [nucleotide binding] 749927005439 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927005440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927005441 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927005442 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927005443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927005444 Walker A/P-loop; other site 749927005445 ATP binding site [chemical binding]; other site 749927005446 Q-loop/lid; other site 749927005447 ABC transporter signature motif; other site 749927005448 Walker B; other site 749927005449 D-loop; other site 749927005450 H-loop/switch region; other site 749927005451 signal recognition particle protein; Provisional; Region: PRK10867 749927005452 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 749927005453 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 749927005454 P loop; other site 749927005455 GTP binding site [chemical binding]; other site 749927005456 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 749927005457 Signal peptide binding domain; Region: SRP_SPB; pfam02978 749927005458 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 749927005459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927005460 active site 749927005461 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927005462 CAAX protease self-immunity; Region: Abi; pfam02517 749927005463 CAAX protease self-immunity; Region: Abi; pfam02517 749927005464 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 749927005465 ribosomal protein S16; Region: S16; TIGR00002 749927005466 hypothetical protein; Provisional; Region: PRK02821 749927005467 G-X-X-G motif; other site 749927005468 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 749927005469 RimM N-terminal domain; Region: RimM; pfam01782 749927005470 PRC-barrel domain; Region: PRC; pfam05239 749927005471 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 749927005472 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 749927005473 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 749927005474 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 749927005475 Catalytic site [active] 749927005476 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 749927005477 RNA/DNA hybrid binding site [nucleotide binding]; other site 749927005478 active site 749927005479 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 749927005480 hypothetical protein; Reviewed; Region: PRK12497 749927005481 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 749927005482 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 749927005483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927005484 Walker A motif; other site 749927005485 ATP binding site [chemical binding]; other site 749927005486 Walker B motif; other site 749927005487 arginine finger; other site 749927005488 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 749927005489 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 749927005490 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 749927005491 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 749927005492 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749927005493 active site 749927005494 DNA binding site [nucleotide binding] 749927005495 Int/Topo IB signature motif; other site 749927005496 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 749927005497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927005498 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 749927005499 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927005500 DNA binding residues [nucleotide binding] 749927005501 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 749927005502 Peptidase family M23; Region: Peptidase_M23; pfam01551 749927005503 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 749927005504 rRNA interaction site [nucleotide binding]; other site 749927005505 S8 interaction site; other site 749927005506 putative laminin-1 binding site; other site 749927005507 elongation factor Ts; Provisional; Region: tsf; PRK09377 749927005508 UBA/TS-N domain; Region: UBA; pfam00627 749927005509 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 749927005510 putative nucleotide binding site [chemical binding]; other site 749927005511 uridine monophosphate binding site [chemical binding]; other site 749927005512 homohexameric interface [polypeptide binding]; other site 749927005513 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 749927005514 hinge region; other site 749927005515 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 749927005516 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 749927005517 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 749927005518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927005519 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749927005520 S-adenosylmethionine binding site [chemical binding]; other site 749927005521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927005522 dimerization interface [polypeptide binding]; other site 749927005523 putative DNA binding site [nucleotide binding]; other site 749927005524 putative Zn2+ binding site [ion binding]; other site 749927005525 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 749927005526 dimer interface [polypeptide binding]; other site 749927005527 putative PBP binding regions; other site 749927005528 ABC-ATPase subunit interface; other site 749927005529 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 749927005530 putative PBP binding regions; other site 749927005531 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 749927005532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927005533 Walker A/P-loop; other site 749927005534 ATP binding site [chemical binding]; other site 749927005535 Q-loop/lid; other site 749927005536 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 749927005537 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 749927005538 siderophore binding site; other site 749927005539 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 749927005540 transketolase; Reviewed; Region: PRK05899 749927005541 TPP-binding site [chemical binding]; other site 749927005542 PYR/PP interface [polypeptide binding]; other site 749927005543 dimer interface [polypeptide binding]; other site 749927005544 TPP binding site [chemical binding]; other site 749927005545 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 749927005546 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 749927005547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927005548 FeS/SAM binding site; other site 749927005549 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 749927005550 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 749927005551 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927005552 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927005553 Creatinine amidohydrolase; Region: Creatininase; pfam02633 749927005554 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927005555 FAD binding domain; Region: FAD_binding_4; pfam01565 749927005556 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749927005557 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749927005558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927005559 dimer interface [polypeptide binding]; other site 749927005560 conserved gate region; other site 749927005561 putative PBP binding loops; other site 749927005562 ABC-ATPase subunit interface; other site 749927005563 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 749927005564 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 749927005565 Walker A/P-loop; other site 749927005566 ATP binding site [chemical binding]; other site 749927005567 Q-loop/lid; other site 749927005568 ABC transporter signature motif; other site 749927005569 Walker B; other site 749927005570 D-loop; other site 749927005571 H-loop/switch region; other site 749927005572 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927005573 cytosine deaminase; Provisional; Region: PRK05985 749927005574 active site 749927005575 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927005576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927005577 non-specific DNA binding site [nucleotide binding]; other site 749927005578 salt bridge; other site 749927005579 sequence-specific DNA binding site [nucleotide binding]; other site 749927005580 Cupin domain; Region: Cupin_2; pfam07883 749927005581 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 749927005582 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 749927005583 FMN-binding pocket [chemical binding]; other site 749927005584 flavin binding motif; other site 749927005585 phosphate binding motif [ion binding]; other site 749927005586 beta-alpha-beta structure motif; other site 749927005587 NAD binding pocket [chemical binding]; other site 749927005588 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927005589 catalytic loop [active] 749927005590 iron binding site [ion binding]; other site 749927005591 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927005592 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 749927005593 active site 749927005594 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 749927005595 Domain of unknown function (DUF955); Region: DUF955; cl01076 749927005596 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 749927005597 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749927005598 molybdopterin cofactor binding site; other site 749927005599 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 749927005600 putative molybdopterin cofactor binding site; other site 749927005601 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927005602 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927005603 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 749927005604 DNA binding residues [nucleotide binding] 749927005605 putative dimer interface [polypeptide binding]; other site 749927005606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927005607 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927005608 putative substrate translocation pore; other site 749927005609 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 749927005610 MoaE interaction surface [polypeptide binding]; other site 749927005611 MoeB interaction surface [polypeptide binding]; other site 749927005612 thiocarboxylated glycine; other site 749927005613 VPS10 domain; Region: VPS10; smart00602 749927005614 VPS10 domain; Region: VPS10; smart00602 749927005615 YCII-related domain; Region: YCII; cl00999 749927005616 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927005617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927005618 NAD(P) binding site [chemical binding]; other site 749927005619 active site 749927005620 Peptidase family M48; Region: Peptidase_M48; cl12018 749927005621 Peptidase family M48; Region: Peptidase_M48; cl12018 749927005622 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927005623 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 749927005624 putative NAD(P) binding site [chemical binding]; other site 749927005625 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927005626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927005627 non-specific DNA binding site [nucleotide binding]; other site 749927005628 salt bridge; other site 749927005629 sequence-specific DNA binding site [nucleotide binding]; other site 749927005630 YCII-related domain; Region: YCII; cl00999 749927005631 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927005632 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927005633 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927005634 DNA binding residues [nucleotide binding] 749927005635 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927005636 substrate binding site [chemical binding]; other site 749927005637 oxyanion hole (OAH) forming residues; other site 749927005638 trimer interface [polypeptide binding]; other site 749927005639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927005640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927005641 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 749927005642 catalytic residues [active] 749927005643 threonine synthase; Validated; Region: PRK06260 749927005644 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 749927005645 homodimer interface [polypeptide binding]; other site 749927005646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927005647 catalytic residue [active] 749927005648 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 749927005649 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927005650 classical (c) SDRs; Region: SDR_c; cd05233 749927005651 NAD(P) binding site [chemical binding]; other site 749927005652 active site 749927005653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927005654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927005655 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 749927005656 dimerization interface [polypeptide binding]; other site 749927005657 substrate binding pocket [chemical binding]; other site 749927005658 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927005659 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927005660 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927005661 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927005662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927005663 non-specific DNA binding site [nucleotide binding]; other site 749927005664 salt bridge; other site 749927005665 sequence-specific DNA binding site [nucleotide binding]; other site 749927005666 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927005667 DNA binding site [nucleotide binding] 749927005668 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927005669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927005670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927005671 TPR motif; other site 749927005672 binding surface 749927005673 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927005674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927005675 TPR motif; other site 749927005676 binding surface 749927005677 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927005678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927005679 binding surface 749927005680 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927005681 TPR motif; other site 749927005682 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927005683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927005684 binding surface 749927005685 TPR motif; other site 749927005686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927005687 hypothetical protein; Provisional; Region: PRK08317 749927005688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927005689 S-adenosylmethionine binding site [chemical binding]; other site 749927005690 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 749927005691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927005692 DNA-binding site [nucleotide binding]; DNA binding site 749927005693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927005694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927005695 homodimer interface [polypeptide binding]; other site 749927005696 catalytic residue [active] 749927005697 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 749927005698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927005699 putative substrate translocation pore; other site 749927005700 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 749927005701 active site 749927005702 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 749927005703 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 749927005704 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 749927005705 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 749927005706 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 749927005707 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 749927005708 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 749927005709 putative substrate binding region [chemical binding]; other site 749927005710 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 749927005711 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 749927005712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927005713 S-adenosylmethionine binding site [chemical binding]; other site 749927005714 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 749927005715 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927005716 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 749927005717 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 749927005718 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 749927005719 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927005720 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 749927005721 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 749927005722 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 749927005723 active site 749927005724 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927005725 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 749927005726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927005727 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 749927005728 Walker A/P-loop; other site 749927005729 ATP binding site [chemical binding]; other site 749927005730 Q-loop/lid; other site 749927005731 ABC transporter signature motif; other site 749927005732 Walker B; other site 749927005733 D-loop; other site 749927005734 H-loop/switch region; other site 749927005735 Uncharacterized conserved protein [Function unknown]; Region: COG3595 749927005736 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 749927005737 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927005738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927005739 DNA-binding site [nucleotide binding]; DNA binding site 749927005740 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 749927005741 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 749927005742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927005743 putative substrate translocation pore; other site 749927005744 mycothione reductase; Reviewed; Region: PRK07846 749927005745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927005746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927005747 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 749927005748 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 749927005749 Trypsin-like serine protease; Region: Tryp_SPc; smart00020 749927005750 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 749927005751 cleavage site 749927005752 active site 749927005753 substrate binding sites [chemical binding]; other site 749927005754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927005755 Coenzyme A binding pocket [chemical binding]; other site 749927005756 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 749927005757 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 749927005758 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927005759 catalytic residue [active] 749927005760 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 749927005761 DEAD-like helicases superfamily; Region: DEXDc; smart00487 749927005762 ATP binding site [chemical binding]; other site 749927005763 Mg++ binding site [ion binding]; other site 749927005764 motif III; other site 749927005765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927005766 nucleotide binding region [chemical binding]; other site 749927005767 ATP-binding site [chemical binding]; other site 749927005768 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 749927005769 ATP binding site [chemical binding]; other site 749927005770 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 749927005771 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 749927005772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927005773 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927005774 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927005775 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 749927005776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927005777 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 749927005778 dimerization interface [polypeptide binding]; other site 749927005779 substrate binding pocket [chemical binding]; other site 749927005780 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 749927005781 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 749927005782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927005783 hypothetical protein; Validated; Region: PRK02101 749927005784 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 749927005785 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927005786 Domain of unknown function (DUF397); Region: DUF397; pfam04149 749927005787 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 749927005788 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 749927005789 putative ligand binding site [chemical binding]; other site 749927005790 putative NAD binding site [chemical binding]; other site 749927005791 catalytic site [active] 749927005792 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 749927005793 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927005794 active site 749927005795 prolyl-tRNA synthetase; Provisional; Region: PRK09194 749927005796 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 749927005797 dimer interface [polypeptide binding]; other site 749927005798 motif 1; other site 749927005799 active site 749927005800 motif 2; other site 749927005801 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 749927005802 putative deacylase active site [active] 749927005803 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 749927005804 anticodon binding site; other site 749927005805 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 749927005806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 749927005807 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 749927005808 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927005809 RHS Repeat; Region: RHS_repeat; pfam05593 749927005810 RHS Repeat; Region: RHS_repeat; pfam05593 749927005811 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927005812 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 749927005813 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 749927005814 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 749927005815 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927005816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927005817 active site 749927005818 phosphorylation site [posttranslational modification] 749927005819 intermolecular recognition site; other site 749927005820 dimerization interface [polypeptide binding]; other site 749927005821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927005822 DNA binding residues [nucleotide binding] 749927005823 Putative sensor; Region: Sensor; pfam13796 749927005824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927005825 Histidine kinase; Region: HisKA_3; pfam07730 749927005826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927005827 ATP binding site [chemical binding]; other site 749927005828 Mg2+ binding site [ion binding]; other site 749927005829 G-X-G motif; other site 749927005830 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 749927005831 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 749927005832 putative di-iron ligands [ion binding]; other site 749927005833 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 749927005834 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 749927005835 FAD binding pocket [chemical binding]; other site 749927005836 FAD binding motif [chemical binding]; other site 749927005837 phosphate binding motif [ion binding]; other site 749927005838 beta-alpha-beta structure motif; other site 749927005839 NAD binding pocket [chemical binding]; other site 749927005840 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927005841 catalytic loop [active] 749927005842 iron binding site [ion binding]; other site 749927005843 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 749927005844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927005845 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 749927005846 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 749927005847 ligand binding site [chemical binding]; other site 749927005848 homodimer interface [polypeptide binding]; other site 749927005849 NAD(P) binding site [chemical binding]; other site 749927005850 trimer interface B [polypeptide binding]; other site 749927005851 trimer interface A [polypeptide binding]; other site 749927005852 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 749927005853 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 749927005854 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 749927005855 Lsr2; Region: Lsr2; pfam11774 749927005856 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 749927005857 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927005858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927005859 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 749927005860 Guanylate-kinase-associated protein (GKAP) protein; Region: GKAP; pfam03359 749927005861 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 749927005862 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 749927005863 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 749927005864 dimer interface [polypeptide binding]; other site 749927005865 active site 749927005866 acyl carrier protein; Provisional; Region: acpP; PRK00982 749927005867 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 749927005868 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 749927005869 dimer interface [polypeptide binding]; other site 749927005870 active site 749927005871 CoA binding pocket [chemical binding]; other site 749927005872 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 749927005873 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 749927005874 putative dimer interface [polypeptide binding]; other site 749927005875 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 749927005876 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927005877 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 749927005878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927005879 Walker A/P-loop; other site 749927005880 ATP binding site [chemical binding]; other site 749927005881 Q-loop/lid; other site 749927005882 ABC transporter signature motif; other site 749927005883 Walker B; other site 749927005884 D-loop; other site 749927005885 H-loop/switch region; other site 749927005886 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 749927005887 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 749927005888 Acyltransferase family; Region: Acyl_transf_3; cl19154 749927005889 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 749927005890 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 749927005891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927005892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927005893 short chain dehydrogenase; Provisional; Region: PRK06500 749927005894 classical (c) SDRs; Region: SDR_c; cd05233 749927005895 NAD(P) binding site [chemical binding]; other site 749927005896 active site 749927005897 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 749927005898 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 749927005899 active site 749927005900 substrate binding site [chemical binding]; other site 749927005901 FMN binding site [chemical binding]; other site 749927005902 putative catalytic residues [active] 749927005903 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 749927005904 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 749927005905 dimer interface [polypeptide binding]; other site 749927005906 TPP-binding site [chemical binding]; other site 749927005907 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 749927005908 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 749927005909 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 749927005910 dimer interface [polypeptide binding]; other site 749927005911 catalytic triad [active] 749927005912 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 749927005913 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 749927005914 catalytic residues [active] 749927005915 catalytic nucleophile [active] 749927005916 Recombinase; Region: Recombinase; pfam07508 749927005917 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 749927005918 DNA methylase; Region: N6_N4_Mtase; pfam01555 749927005919 Replication-relaxation; Region: Replic_Relax; pfam13814 749927005920 AAA-like domain; Region: AAA_10; pfam12846 749927005921 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 749927005922 Walker A motif; other site 749927005923 ATP binding site [chemical binding]; other site 749927005924 Walker B motif; other site 749927005925 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 749927005926 Zn binding site [ion binding]; other site 749927005927 maltose transporter membrane protein; Provisional; Region: malF; PRK10999 749927005928 Immunity protein Imm1; Region: Imm1; pfam14430 749927005929 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 749927005930 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 749927005931 Trypsin-like serine protease; Region: Tryp_SPc; smart00020 749927005932 cleavage site 749927005933 active site 749927005934 substrate binding sites [chemical binding]; other site 749927005935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927005936 non-specific DNA binding site [nucleotide binding]; other site 749927005937 salt bridge; other site 749927005938 sequence-specific DNA binding site [nucleotide binding]; other site 749927005939 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927005940 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927005941 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 749927005942 ThiF family; Region: ThiF; pfam00899 749927005943 ATP binding site [chemical binding]; other site 749927005944 substrate interface [chemical binding]; other site 749927005945 Multiubiquitin; Region: Multi_ubiq; pfam14452 749927005946 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927005947 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 749927005948 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 749927005949 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 749927005950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927005951 putative substrate translocation pore; other site 749927005952 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927005953 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927005954 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927005955 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927005956 putative DNA binding site [nucleotide binding]; other site 749927005957 putative Zn2+ binding site [ion binding]; other site 749927005958 Cupin domain; Region: Cupin_2; pfam07883 749927005959 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927005960 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927005961 active site 749927005962 oxidoreductase; Provisional; Region: PRK06196 749927005963 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 749927005964 NAD(P) binding site [chemical binding]; other site 749927005965 active site 749927005966 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927005967 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927005968 catalytic residue [active] 749927005969 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927005970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927005971 DNA-binding site [nucleotide binding]; DNA binding site 749927005972 FCD domain; Region: FCD; pfam07729 749927005973 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 749927005974 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 749927005975 active site 749927005976 metal binding site [ion binding]; metal-binding site 749927005977 hexamer interface [polypeptide binding]; other site 749927005978 Predicted acyl esterases [General function prediction only]; Region: COG2936 749927005979 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 749927005980 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 749927005981 Aspartase; Region: Aspartase; cd01357 749927005982 active sites [active] 749927005983 tetramer interface [polypeptide binding]; other site 749927005984 L-asparaginase II; Region: Asparaginase_II; pfam06089 749927005985 L-asparagine permease; Provisional; Region: PRK15049 749927005986 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927005987 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927005988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927005989 DNA-binding site [nucleotide binding]; DNA binding site 749927005990 FCD domain; Region: FCD; pfam07729 749927005991 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 749927005992 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 749927005993 active site 749927005994 PHP Thumb interface [polypeptide binding]; other site 749927005995 metal binding site [ion binding]; metal-binding site 749927005996 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 749927005997 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 749927005998 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 749927005999 generic binding surface II; other site 749927006000 generic binding surface I; other site 749927006001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927006002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927006003 putative substrate translocation pore; other site 749927006004 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 749927006005 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 749927006006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 749927006007 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 749927006008 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 749927006009 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 749927006010 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 749927006011 active site 749927006012 nucleophile elbow; other site 749927006013 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 749927006014 lipoyl synthase; Provisional; Region: PRK05481 749927006015 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927006016 FeS/SAM binding site; other site 749927006017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927006018 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 749927006019 NAD(P) binding site [chemical binding]; other site 749927006020 active site 749927006021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927006022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927006023 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 749927006024 lipoate-protein ligase B; Provisional; Region: PRK14345 749927006025 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 749927006026 active site 749927006027 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 749927006028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927006029 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 749927006030 NAD(P) binding site [chemical binding]; other site 749927006031 active site 749927006032 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 749927006033 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749927006034 E3 interaction surface; other site 749927006035 lipoyl attachment site [posttranslational modification]; other site 749927006036 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749927006037 E3 interaction surface; other site 749927006038 lipoyl attachment site [posttranslational modification]; other site 749927006039 e3 binding domain; Region: E3_binding; pfam02817 749927006040 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 749927006041 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 749927006042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927006043 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 749927006044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927006045 Coenzyme A binding pocket [chemical binding]; other site 749927006046 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 749927006047 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 749927006048 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749927006049 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 749927006050 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 749927006051 multifunctional aminopeptidase A; Provisional; Region: PRK00913 749927006052 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 749927006053 interface (dimer of trimers) [polypeptide binding]; other site 749927006054 Substrate-binding/catalytic site; other site 749927006055 Zn-binding sites [ion binding]; other site 749927006056 Protein of unknown function (DUF402); Region: DUF402; pfam04167 749927006057 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 749927006058 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 749927006059 homodimer interface [polypeptide binding]; other site 749927006060 substrate-cofactor binding pocket; other site 749927006061 catalytic residue [active] 749927006062 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 749927006063 putative dimer interface [polypeptide binding]; other site 749927006064 active site pocket [active] 749927006065 putative cataytic base [active] 749927006066 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 749927006067 substrate binding site; other site 749927006068 dimer interface; other site 749927006069 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 749927006070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927006071 DNA-binding site [nucleotide binding]; DNA binding site 749927006072 UTRA domain; Region: UTRA; cl17743 749927006073 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 749927006074 ATP binding site [chemical binding]; other site 749927006075 active site 749927006076 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 749927006077 substrate binding site [chemical binding]; other site 749927006078 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927006079 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927006080 active site 749927006081 catalytic tetrad [active] 749927006082 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 749927006083 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 749927006084 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 749927006085 substrate binding site [chemical binding]; other site 749927006086 ATP binding site [chemical binding]; other site 749927006087 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 749927006088 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 749927006089 active site 749927006090 dimer interface [polypeptide binding]; other site 749927006091 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 749927006092 Ligand Binding Site [chemical binding]; other site 749927006093 Molecular Tunnel; other site 749927006094 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 749927006095 Cupredoxin superfamily; Region: Cupredoxin; cl19115 749927006096 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 749927006097 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 749927006098 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 749927006099 conserved cys residue [active] 749927006100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927006101 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 749927006102 EamA-like transporter family; Region: EamA; pfam00892 749927006103 EamA-like transporter family; Region: EamA; pfam00892 749927006104 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 749927006105 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 749927006106 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 749927006107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 749927006108 active site 749927006109 phosphorylation site [posttranslational modification] 749927006110 intermolecular recognition site; other site 749927006111 dimerization interface [polypeptide binding]; other site 749927006112 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 749927006113 Subunit I/III interface [polypeptide binding]; other site 749927006114 Cytochrome c; Region: Cytochrom_C; cl11414 749927006115 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 749927006116 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 749927006117 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 749927006118 iron-sulfur cluster [ion binding]; other site 749927006119 [2Fe-2S] cluster binding site [ion binding]; other site 749927006120 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 749927006121 heme bH binding site [chemical binding]; other site 749927006122 Qi binding site; other site 749927006123 intrachain domain interface; other site 749927006124 heme bL binding site [chemical binding]; other site 749927006125 interchain domain interface [polypeptide binding]; other site 749927006126 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 749927006127 Qo binding site; other site 749927006128 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927006129 AsnC family; Region: AsnC_trans_reg; pfam01037 749927006130 hypothetical protein; Validated; Region: PRK07883 749927006131 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 749927006132 active site 749927006133 catalytic site [active] 749927006134 substrate binding site [chemical binding]; other site 749927006135 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 749927006136 GIY-YIG motif/motif A; other site 749927006137 active site 749927006138 catalytic site [active] 749927006139 putative DNA binding site [nucleotide binding]; other site 749927006140 metal binding site [ion binding]; metal-binding site 749927006141 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 749927006142 YacP-like NYN domain; Region: NYN_YacP; cl01491 749927006143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 749927006144 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 749927006145 NlpC/P60 family; Region: NLPC_P60; pfam00877 749927006146 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 749927006147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927006148 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 749927006149 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 749927006150 putative hydrophobic ligand binding site [chemical binding]; other site 749927006151 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927006152 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927006153 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927006154 inhibitor-cofactor binding pocket; inhibition site 749927006155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927006156 catalytic residue [active] 749927006157 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 749927006158 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 749927006159 Sulfate transporter family; Region: Sulfate_transp; cl19250 749927006160 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 749927006161 active site clefts [active] 749927006162 zinc binding site [ion binding]; other site 749927006163 dimer interface [polypeptide binding]; other site 749927006164 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 749927006165 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 749927006166 Sulfate transporter family; Region: Sulfate_transp; cl19250 749927006167 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 749927006168 active site clefts [active] 749927006169 zinc binding site [ion binding]; other site 749927006170 dimer interface [polypeptide binding]; other site 749927006171 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 749927006172 biotin synthase; Validated; Region: PRK06256 749927006173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927006174 FeS/SAM binding site; other site 749927006175 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 749927006176 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 749927006177 Peptidase family M48; Region: Peptidase_M48; cl12018 749927006178 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 749927006179 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 749927006180 nudix motif; other site 749927006181 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 749927006182 quinolinate synthetase; Provisional; Region: PRK09375 749927006183 L-aspartate oxidase; Provisional; Region: PRK06175 749927006184 L-aspartate oxidase; Provisional; Region: PRK07804 749927006185 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 749927006186 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 749927006187 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 749927006188 dimerization interface [polypeptide binding]; other site 749927006189 active site 749927006190 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927006191 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 749927006192 active site 749927006193 catalytic residues [active] 749927006194 Sulfatase; Region: Sulfatase; cl19157 749927006195 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 749927006196 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 749927006197 Proteins of 100 residues with WXG; Region: WXG100; cl02005 749927006198 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 749927006199 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927006200 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927006201 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927006202 acyl-activating enzyme (AAE) consensus motif; other site 749927006203 acyl-activating enzyme (AAE) consensus motif; other site 749927006204 AMP binding site [chemical binding]; other site 749927006205 active site 749927006206 CoA binding site [chemical binding]; other site 749927006207 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 749927006208 Trypsin-like serine protease; Region: Tryp_SPc; smart00020 749927006209 cleavage site 749927006210 active site 749927006211 substrate binding sites [chemical binding]; other site 749927006212 Septum formation; Region: Septum_form; pfam13845 749927006213 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 749927006214 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927006215 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 749927006216 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927006217 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927006218 Proteins of 100 residues with WXG; Region: WXG100; cl02005 749927006219 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 749927006220 Flagellar FliJ protein; Region: FliJ; pfam02050 749927006221 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 749927006222 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 749927006223 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 749927006224 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 749927006225 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 749927006226 Protein of unknown function (DUF690); Region: DUF690; cl04939 749927006227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927006228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927006229 active site 749927006230 phosphorylation site [posttranslational modification] 749927006231 intermolecular recognition site; other site 749927006232 dimerization interface [polypeptide binding]; other site 749927006233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927006234 DNA binding residues [nucleotide binding] 749927006235 dimerization interface [polypeptide binding]; other site 749927006236 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927006237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927006238 active site 749927006239 phosphorylation site [posttranslational modification] 749927006240 intermolecular recognition site; other site 749927006241 dimerization interface [polypeptide binding]; other site 749927006242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927006243 DNA binding residues [nucleotide binding] 749927006244 dimerization interface [polypeptide binding]; other site 749927006245 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 749927006246 putative active site [active] 749927006247 catalytic triad [active] 749927006248 putative dimer interface [polypeptide binding]; other site 749927006249 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 749927006250 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 749927006251 NAD binding site [chemical binding]; other site 749927006252 dimerization interface [polypeptide binding]; other site 749927006253 product binding site; other site 749927006254 substrate binding site [chemical binding]; other site 749927006255 zinc binding site [ion binding]; other site 749927006256 catalytic residues [active] 749927006257 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 749927006258 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927006259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927006260 homodimer interface [polypeptide binding]; other site 749927006261 catalytic residue [active] 749927006262 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 749927006263 putative active site pocket [active] 749927006264 4-fold oligomerization interface [polypeptide binding]; other site 749927006265 metal binding residues [ion binding]; metal-binding site 749927006266 3-fold/trimer interface [polypeptide binding]; other site 749927006267 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 749927006268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927006269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927006270 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927006271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927006272 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927006273 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 749927006274 MMPL family; Region: MMPL; cl14618 749927006275 MMPL family; Region: MMPL; cl14618 749927006276 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927006277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927006278 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 749927006279 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 749927006280 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 749927006281 DNA binding residues [nucleotide binding] 749927006282 dimer interface [polypeptide binding]; other site 749927006283 [2Fe-2S] cluster binding site [ion binding]; other site 749927006284 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 749927006285 TPP-binding site [chemical binding]; other site 749927006286 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 749927006287 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 749927006288 PYR/PP interface [polypeptide binding]; other site 749927006289 dimer interface [polypeptide binding]; other site 749927006290 TPP binding site [chemical binding]; other site 749927006291 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 749927006292 nudix motif; other site 749927006293 NIPSNAP; Region: NIPSNAP; pfam07978 749927006294 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927006295 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927006296 active site 749927006297 Glutamine amidotransferase class-I; Region: GATase; pfam00117 749927006298 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 749927006299 putative active site [active] 749927006300 oxyanion strand; other site 749927006301 catalytic triad [active] 749927006302 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 749927006303 catalytic residues [active] 749927006304 classical (c) SDRs; Region: SDR_c; cd05233 749927006305 NAD(P) binding site [chemical binding]; other site 749927006306 active site 749927006307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927006308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927006309 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 749927006310 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927006311 Coenzyme A binding pocket [chemical binding]; other site 749927006312 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927006313 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 749927006314 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386 749927006315 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927006316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927006317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927006318 DNA binding residues [nucleotide binding] 749927006319 Phytase; Region: Phytase; cl17685 749927006320 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 749927006321 substrate binding site [chemical binding]; other site 749927006322 glutamase interaction surface [polypeptide binding]; other site 749927006323 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 749927006324 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 749927006325 Domain of unknown function (DUF397); Region: DUF397; pfam04149 749927006326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927006327 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927006328 non-specific DNA binding site [nucleotide binding]; other site 749927006329 salt bridge; other site 749927006330 sequence-specific DNA binding site [nucleotide binding]; other site 749927006331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927006332 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 749927006333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927006334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927006335 anthranilate synthase component I; Provisional; Region: PRK13571 749927006336 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 749927006337 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 749927006338 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 749927006339 active site 749927006340 ribulose/triose binding site [chemical binding]; other site 749927006341 phosphate binding site [ion binding]; other site 749927006342 substrate (anthranilate) binding pocket [chemical binding]; other site 749927006343 product (indole) binding pocket [chemical binding]; other site 749927006344 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 749927006345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927006346 catalytic residue [active] 749927006347 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 749927006348 substrate binding site [chemical binding]; other site 749927006349 active site 749927006350 catalytic residues [active] 749927006351 heterodimer interface [polypeptide binding]; other site 749927006352 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927006353 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 749927006354 DNA binding residues [nucleotide binding] 749927006355 putative dimer interface [polypeptide binding]; other site 749927006356 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 749927006357 putative active site [active] 749927006358 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 749927006359 amidase catalytic site [active] 749927006360 Zn binding residues [ion binding]; other site 749927006361 substrate binding site [chemical binding]; other site 749927006362 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 749927006363 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 749927006364 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 749927006365 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927006366 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 749927006367 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927006368 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 749927006369 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 749927006370 metal binding site [ion binding]; metal-binding site 749927006371 dimer interface [polypeptide binding]; other site 749927006372 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 749927006373 short chain dehydrogenase; Provisional; Region: PRK07814 749927006374 classical (c) SDRs; Region: SDR_c; cd05233 749927006375 NAD(P) binding site [chemical binding]; other site 749927006376 active site 749927006377 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 749927006378 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 749927006379 active site 749927006380 dimer interface [polypeptide binding]; other site 749927006381 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 749927006382 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 749927006383 active site 749927006384 FMN binding site [chemical binding]; other site 749927006385 substrate binding site [chemical binding]; other site 749927006386 3Fe-4S cluster binding site [ion binding]; other site 749927006387 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 749927006388 domain interface; other site 749927006389 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 749927006390 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 749927006391 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927006392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927006393 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 749927006394 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 749927006395 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927006396 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927006397 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 749927006398 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 749927006399 classical (c) SDRs; Region: SDR_c; cd05233 749927006400 NAD(P) binding site [chemical binding]; other site 749927006401 active site 749927006402 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927006403 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927006404 salt bridge; other site 749927006405 non-specific DNA binding site [nucleotide binding]; other site 749927006406 sequence-specific DNA binding site [nucleotide binding]; other site 749927006407 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 749927006408 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 749927006409 prohibitin homologues; Region: PHB; smart00244 749927006410 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 749927006411 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927006412 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927006413 active site 749927006414 ATP binding site [chemical binding]; other site 749927006415 substrate binding site [chemical binding]; other site 749927006416 activation loop (A-loop); other site 749927006417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 749927006418 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 749927006419 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 749927006420 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 749927006421 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 749927006422 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 749927006423 CGNR zinc finger; Region: zf-CGNR; pfam11706 749927006424 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927006425 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927006426 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 749927006427 active site lid residues [active] 749927006428 substrate binding pocket [chemical binding]; other site 749927006429 catalytic residues [active] 749927006430 substrate-Mg2+ binding site; other site 749927006431 aspartate-rich region 1; other site 749927006432 aspartate-rich region 2; other site 749927006433 phytoene desaturase; Region: crtI_fam; TIGR02734 749927006434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927006435 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 749927006436 substrate binding pocket [chemical binding]; other site 749927006437 chain length determination region; other site 749927006438 substrate-Mg2+ binding site; other site 749927006439 catalytic residues [active] 749927006440 aspartate-rich region 1; other site 749927006441 active site lid residues [active] 749927006442 aspartate-rich region 2; other site 749927006443 Alkylmercury lyase; Region: MerB; pfam03243 749927006444 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 749927006445 FAD binding site [chemical binding]; other site 749927006446 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 749927006447 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 749927006448 EamA-like transporter family; Region: EamA; pfam00892 749927006449 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 749927006450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927006451 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 749927006452 putative deacylase active site [active] 749927006453 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 749927006454 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 749927006455 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927006456 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 749927006457 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927006458 active site 749927006459 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 749927006460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927006461 Coenzyme A binding pocket [chemical binding]; other site 749927006462 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 749927006463 active site 749927006464 catalytic residues [active] 749927006465 metal binding site [ion binding]; metal-binding site 749927006466 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927006467 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 749927006468 ATP binding site [chemical binding]; other site 749927006469 putative Mg++ binding site [ion binding]; other site 749927006470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927006471 nucleotide binding region [chemical binding]; other site 749927006472 ATP-binding site [chemical binding]; other site 749927006473 DEAD/H associated; Region: DEAD_assoc; pfam08494 749927006474 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 749927006475 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 749927006476 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 749927006477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927006478 D-galactonate transporter; Region: 2A0114; TIGR00893 749927006479 putative substrate translocation pore; other site 749927006480 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 749927006481 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 749927006482 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 749927006483 nucleotide binding site [chemical binding]; other site 749927006484 putative NEF/HSP70 interaction site [polypeptide binding]; other site 749927006485 SBD interface [polypeptide binding]; other site 749927006486 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 749927006487 recombinase A; Provisional; Region: recA; PRK09354 749927006488 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 749927006489 hexamer interface [polypeptide binding]; other site 749927006490 Walker A motif; other site 749927006491 ATP binding site [chemical binding]; other site 749927006492 Walker B motif; other site 749927006493 recombination regulator RecX; Reviewed; Region: recX; PRK00117 749927006494 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927006495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927006496 putative substrate translocation pore; other site 749927006497 Entner-Doudoroff aldolase; Region: eda; TIGR01182 749927006498 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 749927006499 active site 749927006500 intersubunit interface [polypeptide binding]; other site 749927006501 catalytic residue [active] 749927006502 phosphogluconate dehydratase; Validated; Region: PRK09054 749927006503 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 749927006504 L-aspartate oxidase; Provisional; Region: PRK06175 749927006505 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 749927006506 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 749927006507 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927006508 catalytic loop [active] 749927006509 iron binding site [ion binding]; other site 749927006510 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 749927006511 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927006512 Coenzyme A binding pocket [chemical binding]; other site 749927006513 Domain of unknown function (DUF397); Region: DUF397; pfam04149 749927006514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927006515 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927006516 non-specific DNA binding site [nucleotide binding]; other site 749927006517 salt bridge; other site 749927006518 sequence-specific DNA binding site [nucleotide binding]; other site 749927006519 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 749927006520 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 749927006521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927006522 NAD(P) binding site [chemical binding]; other site 749927006523 active site 749927006524 ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003 749927006525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927006526 dimer interface [polypeptide binding]; other site 749927006527 conserved gate region; other site 749927006528 putative PBP binding loops; other site 749927006529 ABC-ATPase subunit interface; other site 749927006530 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 749927006531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927006532 dimer interface [polypeptide binding]; other site 749927006533 conserved gate region; other site 749927006534 putative PBP binding loops; other site 749927006535 ABC-ATPase subunit interface; other site 749927006536 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749927006537 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749927006538 substrate binding pocket [chemical binding]; other site 749927006539 membrane-bound complex binding site; other site 749927006540 hinge residues; other site 749927006541 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 749927006542 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 749927006543 Walker A/P-loop; other site 749927006544 ATP binding site [chemical binding]; other site 749927006545 Q-loop/lid; other site 749927006546 ABC transporter signature motif; other site 749927006547 Walker B; other site 749927006548 D-loop; other site 749927006549 H-loop/switch region; other site 749927006550 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927006551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927006552 active site 749927006553 phosphorylation site [posttranslational modification] 749927006554 intermolecular recognition site; other site 749927006555 dimerization interface [polypeptide binding]; other site 749927006556 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927006557 DNA binding site [nucleotide binding] 749927006558 sensory histidine kinase CreC; Provisional; Region: PRK11100 749927006559 HAMP domain; Region: HAMP; pfam00672 749927006560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927006561 dimer interface [polypeptide binding]; other site 749927006562 phosphorylation site [posttranslational modification] 749927006563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927006564 ATP binding site [chemical binding]; other site 749927006565 Mg2+ binding site [ion binding]; other site 749927006566 G-X-G motif; other site 749927006567 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749927006568 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 749927006569 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927006570 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927006571 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 749927006572 active site 749927006573 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 749927006574 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 749927006575 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 749927006576 putative catalytic site [active] 749927006577 putative metal binding site [ion binding]; other site 749927006578 putative phosphate binding site [ion binding]; other site 749927006579 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 749927006580 putative sugar binding site [chemical binding]; other site 749927006581 Protein kinase domain; Region: Pkinase; pfam00069 749927006582 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927006583 active site 749927006584 ATP binding site [chemical binding]; other site 749927006585 substrate binding site [chemical binding]; other site 749927006586 activation loop (A-loop); other site 749927006587 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 749927006588 active site 749927006589 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927006590 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927006591 putative sugar binding sites [chemical binding]; other site 749927006592 Q-X-W motif; other site 749927006593 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 749927006594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927006595 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927006596 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927006597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927006598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927006599 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927006600 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927006601 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 749927006602 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 749927006603 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 749927006604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927006605 FeS/SAM binding site; other site 749927006606 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 749927006607 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 749927006608 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 749927006609 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 749927006610 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 749927006611 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 749927006612 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 749927006613 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 749927006614 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749927006615 active site 749927006616 nucleotide binding site [chemical binding]; other site 749927006617 HIGH motif; other site 749927006618 KMSKS motif; other site 749927006619 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 749927006620 tRNA binding surface [nucleotide binding]; other site 749927006621 anticodon binding site; other site 749927006622 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927006623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927006624 putative substrate translocation pore; other site 749927006625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927006626 putative DNA binding site [nucleotide binding]; other site 749927006627 putative Zn2+ binding site [ion binding]; other site 749927006628 NapD protein; Region: NapD; cl01163 749927006629 GTPases [General function prediction only]; Region: HflX; COG2262 749927006630 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 749927006631 HflX GTPase family; Region: HflX; cd01878 749927006632 G1 box; other site 749927006633 GTP/Mg2+ binding site [chemical binding]; other site 749927006634 Switch I region; other site 749927006635 G2 box; other site 749927006636 G3 box; other site 749927006637 Switch II region; other site 749927006638 G4 box; other site 749927006639 G5 box; other site 749927006640 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 749927006641 LexA repressor; Validated; Region: PRK00215 749927006642 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 749927006643 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 749927006644 Catalytic site [active] 749927006645 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 749927006646 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 749927006647 ATP cone domain; Region: ATP-cone; pfam03477 749927006648 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 749927006649 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 749927006650 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 749927006651 active site 749927006652 dimer interface [polypeptide binding]; other site 749927006653 effector binding site; other site 749927006654 TSCPD domain; Region: TSCPD; pfam12637 749927006655 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 749927006656 metal binding site [ion binding]; metal-binding site 749927006657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927006658 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 749927006659 dinuclear metal binding motif [ion binding]; other site 749927006660 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 749927006661 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 749927006662 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 749927006663 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 749927006664 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl19825 749927006665 TIGR03086 family protein; Region: TIGR03086 749927006666 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927006667 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927006668 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 749927006669 DNA-binding site [nucleotide binding]; DNA binding site 749927006670 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927006671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927006672 homodimer interface [polypeptide binding]; other site 749927006673 catalytic residue [active] 749927006674 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 749927006675 FOG: CBS domain [General function prediction only]; Region: COG0517 749927006676 conserved hypothetical protein; Region: TIGR02231 749927006677 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 749927006678 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 749927006679 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927006680 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 749927006681 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 749927006682 putative active site [active] 749927006683 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927006684 FAD binding domain; Region: FAD_binding_4; pfam01565 749927006685 Berberine and berberine like; Region: BBE; pfam08031 749927006686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927006687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927006688 active site 749927006689 phosphorylation site [posttranslational modification] 749927006690 intermolecular recognition site; other site 749927006691 dimerization interface [polypeptide binding]; other site 749927006692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927006693 DNA binding residues [nucleotide binding] 749927006694 dimerization interface [polypeptide binding]; other site 749927006695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927006696 Histidine kinase; Region: HisKA_3; pfam07730 749927006697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927006698 ATP binding site [chemical binding]; other site 749927006699 Mg2+ binding site [ion binding]; other site 749927006700 G-X-G motif; other site 749927006701 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 749927006702 Peptidase family M23; Region: Peptidase_M23; pfam01551 749927006703 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 749927006704 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 749927006705 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 749927006706 NAD binding site [chemical binding]; other site 749927006707 homodimer interface [polypeptide binding]; other site 749927006708 active site 749927006709 substrate binding site [chemical binding]; other site 749927006710 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 749927006711 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 749927006712 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 749927006713 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 749927006714 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 749927006715 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 749927006716 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 749927006717 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 749927006718 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 749927006719 active site residue [active] 749927006720 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 749927006721 active site residue [active] 749927006722 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 749927006723 active site 749927006724 Zn binding site [ion binding]; other site 749927006725 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927006726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927006727 Coenzyme A binding pocket [chemical binding]; other site 749927006728 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 749927006729 CoA binding domain; Region: CoA_binding_2; pfam13380 749927006730 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 749927006731 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 749927006732 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927006733 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927006734 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 749927006735 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 749927006736 active site 749927006737 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927006738 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927006739 active site 749927006740 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 749927006741 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 749927006742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927006743 NAD(P) binding site [chemical binding]; other site 749927006744 active site 749927006745 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927006746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927006747 NAD(P) binding site [chemical binding]; other site 749927006748 active site 749927006749 Permease; Region: Permease; pfam02405 749927006750 Permease; Region: Permease; pfam02405 749927006751 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927006752 mce related protein; Region: MCE; pfam02470 749927006753 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927006754 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927006755 mce related protein; Region: MCE; pfam02470 749927006756 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927006757 mce related protein; Region: MCE; pfam02470 749927006758 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927006759 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927006760 mce related protein; Region: MCE; pfam02470 749927006761 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927006762 mce related protein; Region: MCE; pfam02470 749927006763 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927006764 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927006765 mce related protein; Region: MCE; pfam02470 749927006766 acyl-CoA thioesterase; Provisional; Region: PRK10531 749927006767 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 749927006768 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927006769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927006770 homodimer interface [polypeptide binding]; other site 749927006771 catalytic residue [active] 749927006772 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 749927006773 dinuclear metal binding motif [ion binding]; other site 749927006774 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927006775 hypothetical protein; Provisional; Region: PRK06847 749927006776 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927006777 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927006778 DNA binding site [nucleotide binding] 749927006779 domain linker motif; other site 749927006780 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927006781 ligand binding site [chemical binding]; other site 749927006782 dimerization interface [polypeptide binding]; other site 749927006783 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927006784 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 749927006785 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927006786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927006787 dimer interface [polypeptide binding]; other site 749927006788 conserved gate region; other site 749927006789 putative PBP binding loops; other site 749927006790 ABC-ATPase subunit interface; other site 749927006791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 749927006792 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927006793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927006794 dimer interface [polypeptide binding]; other site 749927006795 conserved gate region; other site 749927006796 putative PBP binding loops; other site 749927006797 ABC-ATPase subunit interface; other site 749927006798 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 749927006799 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 749927006800 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 749927006801 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 749927006802 acyl-activating enzyme (AAE) consensus motif; other site 749927006803 putative AMP binding site [chemical binding]; other site 749927006804 putative active site [active] 749927006805 putative CoA binding site [chemical binding]; other site 749927006806 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927006807 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927006808 active site 749927006809 metal binding site [ion binding]; metal-binding site 749927006810 metal binding site [ion binding]; metal-binding site 749927006811 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 749927006812 putative hydrophobic ligand binding site [chemical binding]; other site 749927006813 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 749927006814 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 749927006815 P loop; other site 749927006816 Nucleotide binding site [chemical binding]; other site 749927006817 DTAP/Switch II; other site 749927006818 Switch I; other site 749927006819 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 749927006820 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 749927006821 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927006822 nucleotide binding site [chemical binding]; other site 749927006823 NUDIX domain; Region: NUDIX; pfam00293 749927006824 nudix motif; other site 749927006825 YacP-like NYN domain; Region: NYN_YacP; cl01491 749927006826 carboxylate-amine ligase; Provisional; Region: PRK13517 749927006827 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927006828 Esterase/lipase [General function prediction only]; Region: COG1647 749927006829 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 749927006830 putative acyl-acceptor binding pocket; other site 749927006831 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 749927006832 phosphofructokinase; Region: PFK_mixed; TIGR02483 749927006833 active site 749927006834 ADP/pyrophosphate binding site [chemical binding]; other site 749927006835 dimerization interface [polypeptide binding]; other site 749927006836 allosteric effector site; other site 749927006837 fructose-1,6-bisphosphate binding site; other site 749927006838 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 749927006839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927006840 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927006841 DNA binding residues [nucleotide binding] 749927006842 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 749927006843 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 749927006844 active sites [active] 749927006845 tetramer interface [polypeptide binding]; other site 749927006846 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 749927006847 heme-binding site [chemical binding]; other site 749927006848 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927006849 dimerization interface [polypeptide binding]; other site 749927006850 putative Zn2+ binding site [ion binding]; other site 749927006851 putative DNA binding site [nucleotide binding]; other site 749927006852 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927006853 dimerization interface [polypeptide binding]; other site 749927006854 putative DNA binding site [nucleotide binding]; other site 749927006855 putative Zn2+ binding site [ion binding]; other site 749927006856 Glyco_18 domain; Region: Glyco_18; smart00636 749927006857 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 749927006858 active site 749927006859 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 749927006860 pyruvate kinase; Provisional; Region: PRK06247 749927006861 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 749927006862 active site 749927006863 domain interfaces; other site 749927006864 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 749927006865 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 749927006866 active site 749927006867 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 749927006868 catalytic triad [active] 749927006869 dimer interface [polypeptide binding]; other site 749927006870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927006871 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927006872 non-specific DNA binding site [nucleotide binding]; other site 749927006873 salt bridge; other site 749927006874 sequence-specific DNA binding site [nucleotide binding]; other site 749927006875 Domain of unknown function (DUF397); Region: DUF397; pfam04149 749927006876 Predicted ATPase [General function prediction only]; Region: COG3899 749927006877 AAA ATPase domain; Region: AAA_16; pfam13191 749927006878 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927006879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927006880 DNA binding residues [nucleotide binding] 749927006881 dimerization interface [polypeptide binding]; other site 749927006882 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 749927006883 NAD(P) binding site [chemical binding]; other site 749927006884 catalytic residues [active] 749927006885 DNA translocase FtsK; Provisional; Region: PRK10263 749927006886 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 749927006887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927006888 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927006889 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927006890 active site 749927006891 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927006892 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 749927006893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927006894 enoyl-CoA hydratase; Provisional; Region: PRK08259 749927006895 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927006896 substrate binding site [chemical binding]; other site 749927006897 oxyanion hole (OAH) forming residues; other site 749927006898 trimer interface [polypeptide binding]; other site 749927006899 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 749927006900 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749927006901 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749927006902 Glucitol operon activator protein (GutM); Region: GutM; cl01890 749927006903 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 749927006904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927006905 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927006906 putative substrate translocation pore; other site 749927006907 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927006908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927006909 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 749927006910 Na binding site [ion binding]; other site 749927006911 Protein of unknown function, DUF485; Region: DUF485; pfam04341 749927006912 Nitrate and nitrite sensing; Region: NIT; pfam08376 749927006913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927006914 ATP binding site [chemical binding]; other site 749927006915 Mg2+ binding site [ion binding]; other site 749927006916 G-X-G motif; other site 749927006917 Psoriasis susceptibility locus 2; Region: SPR1; pfam15356 749927006918 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 749927006919 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927006920 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 749927006921 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 749927006922 G1 box; other site 749927006923 GTP/Mg2+ binding site [chemical binding]; other site 749927006924 G2 box; other site 749927006925 Switch I region; other site 749927006926 G3 box; other site 749927006927 Switch II region; other site 749927006928 G4 box; other site 749927006929 G5 box; other site 749927006930 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 749927006931 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927006932 hydrophobic ligand binding site; other site 749927006933 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927006934 dimerization interface [polypeptide binding]; other site 749927006935 putative DNA binding site [nucleotide binding]; other site 749927006936 putative Zn2+ binding site [ion binding]; other site 749927006937 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 749927006938 B12 binding site [chemical binding]; other site 749927006939 cobalt ligand [ion binding]; other site 749927006940 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 749927006941 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927006942 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 749927006943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927006944 S-adenosylmethionine binding site [chemical binding]; other site 749927006945 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 749927006946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927006947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927006948 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927006949 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927006950 active site 749927006951 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927006952 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927006953 active site 749927006954 SNF2 Helicase protein; Region: DUF3670; pfam12419 749927006955 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 749927006956 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927006957 ATP binding site [chemical binding]; other site 749927006958 putative Mg++ binding site [ion binding]; other site 749927006959 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 749927006960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927006961 nucleotide binding region [chemical binding]; other site 749927006962 ATP-binding site [chemical binding]; other site 749927006963 SWIM zinc finger; Region: SWIM; cl19527 749927006964 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 749927006965 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927006966 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927006967 substrate binding pocket [chemical binding]; other site 749927006968 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 749927006969 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 749927006970 Domain of unknown function (DUF385); Region: DUF385; pfam04075 749927006971 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927006972 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927006973 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927006974 active site 749927006975 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927006976 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927006977 active site 749927006978 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 749927006979 active site 749927006980 catalytic site [active] 749927006981 DUF35 OB-fold domain; Region: DUF35; pfam01796 749927006982 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 749927006983 putative active site [active] 749927006984 putative catalytic site [active] 749927006985 lipid-transfer protein; Provisional; Region: PRK07855 749927006986 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 749927006987 active site 749927006988 Riboflavin kinase; Region: Flavokinase; smart00904 749927006989 enoyl-CoA hydratase; Region: PLN02864 749927006990 N-terminal half of MaoC dehydratase; Region: MaoC_dehydrat_N; pfam13452 749927006991 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 749927006992 dimer interaction site [polypeptide binding]; other site 749927006993 substrate-binding tunnel; other site 749927006994 active site 749927006995 catalytic site [active] 749927006996 substrate binding site [chemical binding]; other site 749927006997 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 749927006998 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 749927006999 FAD binding pocket [chemical binding]; other site 749927007000 FAD binding motif [chemical binding]; other site 749927007001 phosphate binding motif [ion binding]; other site 749927007002 beta-alpha-beta structure motif; other site 749927007003 NAD(p) ribose binding residues [chemical binding]; other site 749927007004 NAD binding pocket [chemical binding]; other site 749927007005 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 749927007006 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927007007 catalytic loop [active] 749927007008 iron binding site [ion binding]; other site 749927007009 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 749927007010 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 749927007011 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 749927007012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927007013 hypothetical protein; Validated; Region: PRK07121 749927007014 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927007015 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927007016 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 749927007017 Flavin binding site [chemical binding]; other site 749927007018 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 749927007019 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927007020 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 749927007021 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 749927007022 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 749927007023 active site 749927007024 Fe binding site [ion binding]; other site 749927007025 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 749927007026 Smr domain; Region: Smr; pfam01713 749927007027 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 749927007028 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 749927007029 putative di-iron ligands [ion binding]; other site 749927007030 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 749927007031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927007032 Walker A/P-loop; other site 749927007033 ATP binding site [chemical binding]; other site 749927007034 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927007035 ABC transporter signature motif; other site 749927007036 Walker B; other site 749927007037 D-loop; other site 749927007038 H-loop/switch region; other site 749927007039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927007040 Walker A/P-loop; other site 749927007041 ATP binding site [chemical binding]; other site 749927007042 Q-loop/lid; other site 749927007043 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 749927007044 ABC transporter signature motif; other site 749927007045 Walker B; other site 749927007046 D-loop; other site 749927007047 H-loop/switch region; other site 749927007048 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 749927007049 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 749927007050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927007051 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 749927007052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927007053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927007054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927007055 dimerization interface [polypeptide binding]; other site 749927007056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927007057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927007058 putative substrate translocation pore; other site 749927007059 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 749927007060 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927007061 Reductase C-terminal; Region: Reductase_C; pfam14759 749927007062 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 749927007063 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 749927007064 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 749927007065 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 749927007066 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927007067 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927007068 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927007069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927007070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927007071 DNA binding residues [nucleotide binding] 749927007072 Putative zinc-finger; Region: zf-HC2; pfam13490 749927007073 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 749927007074 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927007075 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927007076 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927007077 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927007078 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927007079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927007080 AsnC family; Region: AsnC_trans_reg; pfam01037 749927007081 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927007082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927007083 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 749927007084 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 749927007085 metal binding site [ion binding]; metal-binding site 749927007086 dimer interface [polypeptide binding]; other site 749927007087 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 749927007088 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927007089 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 749927007090 active site 749927007091 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927007092 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927007093 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927007094 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 749927007095 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927007096 dimer interface [polypeptide binding]; other site 749927007097 active site 749927007098 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927007099 Dienelactone hydrolase family; Region: DLH; pfam01738 749927007100 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 749927007101 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 749927007102 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 749927007103 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 749927007104 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 749927007105 active site 749927007106 lipid-transfer protein; Provisional; Region: PRK07937 749927007107 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 749927007108 active site 749927007109 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 749927007110 DUF35 OB-fold domain; Region: DUF35; pfam01796 749927007111 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 749927007112 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 749927007113 DUF35 OB-fold domain; Region: DUF35; pfam01796 749927007114 enoyl-CoA hydratase; Provisional; Region: PRK07799 749927007115 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927007116 substrate binding site [chemical binding]; other site 749927007117 oxyanion hole (OAH) forming residues; other site 749927007118 trimer interface [polypeptide binding]; other site 749927007119 acyl-CoA synthetase; Validated; Region: PRK07798 749927007120 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927007121 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 749927007122 acyl-activating enzyme (AAE) consensus motif; other site 749927007123 acyl-activating enzyme (AAE) consensus motif; other site 749927007124 putative AMP binding site [chemical binding]; other site 749927007125 putative active site [active] 749927007126 putative CoA binding site [chemical binding]; other site 749927007127 Nitronate monooxygenase; Region: NMO; pfam03060 749927007128 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 749927007129 FMN binding site [chemical binding]; other site 749927007130 substrate binding site [chemical binding]; other site 749927007131 putative catalytic residue [active] 749927007132 Trypsin-like serine protease; Region: Tryp_SPc; smart00020 749927007133 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 749927007134 cleavage site 749927007135 active site 749927007136 substrate binding sites [chemical binding]; other site 749927007137 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 749927007138 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927007139 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 749927007140 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927007141 DNA-binding site [nucleotide binding]; DNA binding site 749927007142 UTRA domain; Region: UTRA; pfam07702 749927007143 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 749927007144 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 749927007145 fumarate hydratase; Provisional; Region: PRK15389 749927007146 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 749927007147 Fumarase C-terminus; Region: Fumerase_C; pfam05683 749927007148 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 749927007149 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 749927007150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927007151 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 749927007152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927007153 DNA binding residues [nucleotide binding] 749927007154 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 749927007155 putative active site [active] 749927007156 dimerization interface [polypeptide binding]; other site 749927007157 putative tRNAtyr binding site [nucleotide binding]; other site 749927007158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927007159 S-adenosylmethionine binding site [chemical binding]; other site 749927007160 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 749927007161 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 749927007162 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 749927007163 metal binding site [ion binding]; metal-binding site 749927007164 putative dimer interface [polypeptide binding]; other site 749927007165 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 749927007166 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 749927007167 substrate binding site [chemical binding]; other site 749927007168 ATP binding site [chemical binding]; other site 749927007169 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 749927007170 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 749927007171 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; cl19290 749927007172 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 749927007173 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 749927007174 MMPL family; Region: MMPL; cl14618 749927007175 MMPL family; Region: MMPL; cl14618 749927007176 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 749927007177 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 749927007178 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927007179 ATP binding site [chemical binding]; other site 749927007180 putative Mg++ binding site [ion binding]; other site 749927007181 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 749927007182 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 749927007183 putative ligand binding site [chemical binding]; other site 749927007184 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 749927007185 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927007186 Walker A/P-loop; other site 749927007187 ATP binding site [chemical binding]; other site 749927007188 Q-loop/lid; other site 749927007189 ABC transporter signature motif; other site 749927007190 Walker B; other site 749927007191 D-loop; other site 749927007192 H-loop/switch region; other site 749927007193 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927007194 TM-ABC transporter signature motif; other site 749927007195 Helix-turn-helix domain; Region: HTH_20; pfam12840 749927007196 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927007197 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927007198 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 749927007199 EamA-like transporter family; Region: EamA; pfam00892 749927007200 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 749927007201 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 749927007202 amino acid transporter; Region: 2A0306; TIGR00909 749927007203 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927007204 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 749927007205 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 749927007206 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 749927007207 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 749927007208 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 749927007209 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 749927007210 active site 749927007211 catalytic site [active] 749927007212 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 749927007213 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 749927007214 active site 749927007215 catalytic site [active] 749927007216 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 749927007217 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 749927007218 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 749927007219 catalytic site [active] 749927007220 active site 749927007221 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 749927007222 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 749927007223 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 749927007224 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 749927007225 active site 749927007226 catalytic site [active] 749927007227 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 749927007228 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 749927007229 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 749927007230 active site 749927007231 catalytic site [active] 749927007232 trehalose synthase; Region: treS_nterm; TIGR02456 749927007233 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 749927007234 active site 749927007235 catalytic site [active] 749927007236 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl19286 749927007237 glycogen branching enzyme; Provisional; Region: PRK05402 749927007238 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 749927007239 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 749927007240 active site 749927007241 catalytic site [active] 749927007242 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 749927007243 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 749927007244 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 749927007245 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927007246 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 749927007247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927007248 DNA binding residues [nucleotide binding] 749927007249 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927007250 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927007251 nucleotide binding site [chemical binding]; other site 749927007252 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 749927007253 active site 749927007254 dimerization interface [polypeptide binding]; other site 749927007255 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 749927007256 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 749927007257 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 749927007258 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 749927007259 trimer interface [polypeptide binding]; other site 749927007260 active site 749927007261 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 749927007262 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927007263 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 749927007264 generic binding surface II; other site 749927007265 ssDNA binding site; other site 749927007266 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 749927007267 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 749927007268 TrkA-N domain; Region: TrkA_N; pfam02254 749927007269 TrkA-C domain; Region: TrkA_C; pfam02080 749927007270 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 749927007271 TrkA-N domain; Region: TrkA_N; pfam02254 749927007272 TrkA-C domain; Region: TrkA_C; pfam02080 749927007273 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 749927007274 K+ potassium transporter; Region: K_trans; cl15781 749927007275 TRAM domain; Region: TRAM; pfam01938 749927007276 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 749927007277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927007278 S-adenosylmethionine binding site [chemical binding]; other site 749927007279 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927007280 TIGR03086 family protein; Region: TIGR03086 749927007281 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927007282 NAD(P) binding site [chemical binding]; other site 749927007283 catalytic residues [active] 749927007284 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 749927007285 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 749927007286 TPP-binding site; other site 749927007287 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 749927007288 PYR/PP interface [polypeptide binding]; other site 749927007289 dimer interface [polypeptide binding]; other site 749927007290 TPP binding site [chemical binding]; other site 749927007291 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 749927007292 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 749927007293 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927007294 ligand binding site [chemical binding]; other site 749927007295 dimerization interface [polypeptide binding]; other site 749927007296 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 749927007297 tetrameric interface [polypeptide binding]; other site 749927007298 NAD binding site [chemical binding]; other site 749927007299 catalytic residues [active] 749927007300 substrate binding site [chemical binding]; other site 749927007301 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 749927007302 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749927007303 PYR/PP interface [polypeptide binding]; other site 749927007304 dimer interface [polypeptide binding]; other site 749927007305 TPP binding site [chemical binding]; other site 749927007306 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927007307 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 749927007308 TPP-binding site [chemical binding]; other site 749927007309 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 749927007310 oligomer interface [polypeptide binding]; other site 749927007311 putative active site [active] 749927007312 Mn binding site [ion binding]; other site 749927007313 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 749927007314 Na binding site [ion binding]; other site 749927007315 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 749927007316 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927007317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927007318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927007319 active site 749927007320 phosphorylation site [posttranslational modification] 749927007321 intermolecular recognition site; other site 749927007322 dimerization interface [polypeptide binding]; other site 749927007323 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927007324 DNA binding site [nucleotide binding] 749927007325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927007326 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927007327 dimerization interface [polypeptide binding]; other site 749927007328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927007329 dimer interface [polypeptide binding]; other site 749927007330 phosphorylation site [posttranslational modification] 749927007331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927007332 ATP binding site [chemical binding]; other site 749927007333 Mg2+ binding site [ion binding]; other site 749927007334 G-X-G motif; other site 749927007335 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927007336 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927007337 PHP domain; Region: PHP; pfam02811 749927007338 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 749927007339 active site 749927007340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927007341 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 749927007342 substrate binding site [chemical binding]; other site 749927007343 oxyanion hole (OAH) forming residues; other site 749927007344 trimer interface [polypeptide binding]; other site 749927007345 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927007346 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927007347 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927007348 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 749927007349 dimer interface [polypeptide binding]; other site 749927007350 active site 749927007351 allophanate hydrolase; Provisional; Region: PRK08186 749927007352 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749927007353 urea carboxylase; Region: urea_carbox; TIGR02712 749927007354 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927007355 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 749927007356 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 749927007357 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 749927007358 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 749927007359 carboxyltransferase (CT) interaction site; other site 749927007360 biotinylation site [posttranslational modification]; other site 749927007361 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 749927007362 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 749927007363 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 749927007364 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927007365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927007366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927007367 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 749927007368 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 749927007369 catalytic site [active] 749927007370 putative active site [active] 749927007371 putative substrate binding site [chemical binding]; other site 749927007372 HRDC domain; Region: HRDC; cl02578 749927007373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927007374 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927007375 active site 749927007376 phosphorylation site [posttranslational modification] 749927007377 intermolecular recognition site; other site 749927007378 dimerization interface [polypeptide binding]; other site 749927007379 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927007380 DNA binding residues [nucleotide binding] 749927007381 dimerization interface [polypeptide binding]; other site 749927007382 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 749927007383 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 749927007384 substrate binding site [chemical binding]; other site 749927007385 active site 749927007386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927007387 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 749927007388 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 749927007389 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927007390 hypothetical protein; Provisional; Region: PRK05409 749927007391 TIGR04222 domain; Region: near_uncomplex 749927007392 TIGR04222 domain; Region: near_uncomplex 749927007393 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 749927007394 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927007395 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927007396 active site 749927007397 ATP binding site [chemical binding]; other site 749927007398 substrate binding site [chemical binding]; other site 749927007399 activation loop (A-loop); other site 749927007400 Uncharacterized conserved protein [Function unknown]; Region: COG0398 749927007401 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 749927007402 nucleotide binding site [chemical binding]; other site 749927007403 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 749927007404 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 749927007405 RNA binding site [nucleotide binding]; other site 749927007406 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 749927007407 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 749927007408 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927007409 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 749927007410 Glutamate binding site [chemical binding]; other site 749927007411 NAD binding site [chemical binding]; other site 749927007412 catalytic residues [active] 749927007413 Proline dehydrogenase; Region: Pro_dh; pfam01619 749927007414 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 749927007415 catalytic residues [active] 749927007416 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 749927007417 YCII-related domain; Region: YCII; cl00999 749927007418 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 749927007419 putative dimer interface [polypeptide binding]; other site 749927007420 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927007421 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927007422 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927007423 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927007424 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927007425 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 749927007426 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 749927007427 active site 749927007428 DNA binding site [nucleotide binding] 749927007429 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 749927007430 DNA binding site [nucleotide binding] 749927007431 Asp23 family; Region: Asp23; pfam03780 749927007432 Asp23 family; Region: Asp23; pfam03780 749927007433 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 749927007434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927007435 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927007436 DNA binding residues [nucleotide binding] 749927007437 hypothetical protein; Provisional; Region: PRK14059 749927007438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927007439 Walker A motif; other site 749927007440 ATP binding site [chemical binding]; other site 749927007441 Walker B motif; other site 749927007442 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 749927007443 active site 749927007444 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 749927007445 FAD dependent oxidoreductase; Region: DAO; pfam01266 749927007446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927007447 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 749927007448 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 749927007449 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927007450 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927007451 inhibitor-cofactor binding pocket; inhibition site 749927007452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927007453 catalytic residue [active] 749927007454 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927007455 dimerization interface [polypeptide binding]; other site 749927007456 putative DNA binding site [nucleotide binding]; other site 749927007457 putative Zn2+ binding site [ion binding]; other site 749927007458 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 749927007459 putative hydrophobic ligand binding site [chemical binding]; other site 749927007460 CLM binding site; other site 749927007461 L1 loop; other site 749927007462 DNA binding site [nucleotide binding] 749927007463 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 749927007464 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 749927007465 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 749927007466 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927007467 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927007468 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 749927007469 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 749927007470 CrcB-like protein; Region: CRCB; pfam02537 749927007471 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 749927007472 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927007473 catalytic residue [active] 749927007474 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 749927007475 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927007476 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 749927007477 IucA / IucC family; Region: IucA_IucC; pfam04183 749927007478 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 749927007479 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 749927007480 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 749927007481 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927007482 FAD binding domain; Region: FAD_binding_4; pfam01565 749927007483 Berberine and berberine like; Region: BBE; pfam08031 749927007484 Bacterial transcriptional activator domain; Region: BTAD; smart01043 749927007485 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 749927007486 AAA ATPase domain; Region: AAA_16; pfam13191 749927007487 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 749927007488 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927007489 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927007490 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 749927007491 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 749927007492 protein-splicing catalytic site; other site 749927007493 thioester formation/cholesterol transfer; other site 749927007494 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 749927007495 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 749927007496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927007497 FeS/SAM binding site; other site 749927007498 Alkylmercury lyase; Region: MerB; pfam03243 749927007499 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 749927007500 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 749927007501 dimer interface [polypeptide binding]; other site 749927007502 anticodon binding site; other site 749927007503 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 749927007504 homodimer interface [polypeptide binding]; other site 749927007505 motif 1; other site 749927007506 active site 749927007507 motif 2; other site 749927007508 GAD domain; Region: GAD; pfam02938 749927007509 motif 3; other site 749927007510 Domain of unknown function (DUF389); Region: DUF389; cl00781 749927007511 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 749927007512 active site 749927007513 catalytic triad [active] 749927007514 oxyanion hole [active] 749927007515 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 749927007516 active site 749927007517 metal binding site [ion binding]; metal-binding site 749927007518 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927007519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927007520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927007521 recombination factor protein RarA; Reviewed; Region: PRK13342 749927007522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927007523 Walker A motif; other site 749927007524 ATP binding site [chemical binding]; other site 749927007525 Walker B motif; other site 749927007526 arginine finger; other site 749927007527 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 749927007528 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927007529 active site 749927007530 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 749927007531 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 749927007532 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 749927007533 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 749927007534 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 749927007535 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 749927007536 motif 1; other site 749927007537 active site 749927007538 motif 2; other site 749927007539 motif 3; other site 749927007540 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 749927007541 Heat shock factor binding protein 1; Region: HSBP1; pfam06825 749927007542 DHHA1 domain; Region: DHHA1; pfam02272 749927007543 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 749927007544 YceG-like family; Region: YceG; pfam02618 749927007545 dimerization interface [polypeptide binding]; other site 749927007546 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 749927007547 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 749927007548 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 749927007549 NAD(P) binding pocket [chemical binding]; other site 749927007550 GrpB protein; Region: GrpB; pfam04229 749927007551 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749927007552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927007553 S-adenosylmethionine binding site [chemical binding]; other site 749927007554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927007555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927007556 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 749927007557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927007558 dimerization interface [polypeptide binding]; other site 749927007559 putative DNA binding site [nucleotide binding]; other site 749927007560 putative Zn2+ binding site [ion binding]; other site 749927007561 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 749927007562 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 749927007563 dimerization interface [polypeptide binding]; other site 749927007564 NAD binding site [chemical binding]; other site 749927007565 ligand binding site [chemical binding]; other site 749927007566 catalytic site [active] 749927007567 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927007568 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 749927007569 dimerization domain swap beta strand [polypeptide binding]; other site 749927007570 regulatory protein interface [polypeptide binding]; other site 749927007571 active site 749927007572 regulatory phosphorylation site [posttranslational modification]; other site 749927007573 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 749927007574 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 749927007575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927007576 DNA-binding site [nucleotide binding]; DNA binding site 749927007577 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 749927007578 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 749927007579 active site turn [active] 749927007580 phosphorylation site [posttranslational modification] 749927007581 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 749927007582 HPr interaction site; other site 749927007583 glycerol kinase (GK) interaction site [polypeptide binding]; other site 749927007584 active site 749927007585 phosphorylation site [posttranslational modification] 749927007586 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 749927007587 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 749927007588 iron-sulfur cluster [ion binding]; other site 749927007589 [2Fe-2S] cluster binding site [ion binding]; other site 749927007590 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 749927007591 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927007592 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927007593 DNA binding residues [nucleotide binding] 749927007594 Putative zinc-finger; Region: zf-HC2; pfam13490 749927007595 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 749927007596 Tetramer interface [polypeptide binding]; other site 749927007597 active site 749927007598 FMN-binding site [chemical binding]; other site 749927007599 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 749927007600 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 749927007601 ADP binding site [chemical binding]; other site 749927007602 magnesium binding site [ion binding]; other site 749927007603 putative shikimate binding site; other site 749927007604 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 749927007605 active site 749927007606 dimer interface [polypeptide binding]; other site 749927007607 metal binding site [ion binding]; metal-binding site 749927007608 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 749927007609 trimer interface [polypeptide binding]; other site 749927007610 active site 749927007611 dimer interface [polypeptide binding]; other site 749927007612 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927007613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927007614 Coenzyme A binding pocket [chemical binding]; other site 749927007615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927007616 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 749927007617 putative dimer interface [polypeptide binding]; other site 749927007618 ligand binding site [chemical binding]; other site 749927007619 Zn binding site [ion binding]; other site 749927007620 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 749927007621 active site 749927007622 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 749927007623 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 749927007624 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 749927007625 active site 749927007626 elongation factor P; Validated; Region: PRK00529 749927007627 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 749927007628 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 749927007629 RNA binding site [nucleotide binding]; other site 749927007630 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 749927007631 RNA binding site [nucleotide binding]; other site 749927007632 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 749927007633 putative RNA binding site [nucleotide binding]; other site 749927007634 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927007635 active site 749927007636 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927007637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927007638 non-specific DNA binding site [nucleotide binding]; other site 749927007639 salt bridge; other site 749927007640 sequence-specific DNA binding site [nucleotide binding]; other site 749927007641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927007642 active site 749927007643 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 749927007644 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 749927007645 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 749927007646 dihydroorotase; Validated; Region: pyrC; PRK09357 749927007647 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927007648 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 749927007649 active site 749927007650 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 749927007651 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 749927007652 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 749927007653 catalytic site [active] 749927007654 subunit interface [polypeptide binding]; other site 749927007655 Predicted ATPase [General function prediction only]; Region: COG4637 749927007656 AAA domain; Region: AAA_23; pfam13476 749927007657 Walker A/P-loop; other site 749927007658 ATP binding site [chemical binding]; other site 749927007659 AAA domain; Region: AAA_21; pfam13304 749927007660 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 749927007661 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 749927007662 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749927007663 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927007664 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 749927007665 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749927007666 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927007667 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 749927007668 IMP binding site; other site 749927007669 dimer interface [polypeptide binding]; other site 749927007670 interdomain contacts; other site 749927007671 partial ornithine binding site; other site 749927007672 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 749927007673 active site 749927007674 dimer interface [polypeptide binding]; other site 749927007675 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 749927007676 catalytic site [active] 749927007677 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 749927007678 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 749927007679 Flavoprotein; Region: Flavoprotein; cl19190 749927007680 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 749927007681 S-adenosylmethionine synthetase; Validated; Region: PRK05250 749927007682 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 749927007683 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 749927007684 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 749927007685 primosome assembly protein PriA; Provisional; Region: PRK14873 749927007686 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 749927007687 CotH protein; Region: CotH; cl19892 749927007688 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 749927007689 putative substrate binding pocket [chemical binding]; other site 749927007690 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 749927007691 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 749927007692 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 749927007693 putative active site [active] 749927007694 substrate binding site [chemical binding]; other site 749927007695 putative cosubstrate binding site; other site 749927007696 catalytic site [active] 749927007697 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 749927007698 substrate binding site [chemical binding]; other site 749927007699 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 749927007700 putative RNA binding site [nucleotide binding]; other site 749927007701 16S rRNA methyltransferase B; Provisional; Region: PRK14901 749927007702 Flavoprotein; Region: Flavoprotein; cl19190 749927007703 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927007704 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 749927007705 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 749927007706 dimer interface [polypeptide binding]; other site 749927007707 active site 749927007708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927007709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927007710 active site 749927007711 phosphorylation site [posttranslational modification] 749927007712 intermolecular recognition site; other site 749927007713 dimerization interface [polypeptide binding]; other site 749927007714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927007715 DNA binding residues [nucleotide binding] 749927007716 dimerization interface [polypeptide binding]; other site 749927007717 Histidine kinase; Region: HisKA_3; pfam07730 749927007718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927007719 ATP binding site [chemical binding]; other site 749927007720 Mg2+ binding site [ion binding]; other site 749927007721 G-X-G motif; other site 749927007722 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 749927007723 substrate binding site [chemical binding]; other site 749927007724 hexamer interface [polypeptide binding]; other site 749927007725 metal binding site [ion binding]; metal-binding site 749927007726 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 749927007727 Lumazine binding domain; Region: Lum_binding; pfam00677 749927007728 Lumazine binding domain; Region: Lum_binding; pfam00677 749927007729 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 749927007730 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 749927007731 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 749927007732 dimerization interface [polypeptide binding]; other site 749927007733 active site 749927007734 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 749927007735 homopentamer interface [polypeptide binding]; other site 749927007736 active site 749927007737 Bacterial PH domain; Region: bPH_6; pfam10756 749927007738 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 749927007739 putative catalytic site [active] 749927007740 putative phosphate binding site [ion binding]; other site 749927007741 active site 749927007742 metal binding site A [ion binding]; metal-binding site 749927007743 DNA binding site [nucleotide binding] 749927007744 putative AP binding site [nucleotide binding]; other site 749927007745 putative metal binding site B [ion binding]; other site 749927007746 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 749927007747 Trypsin-like serine protease; Region: Tryp_SPc; smart00020 749927007748 cleavage site 749927007749 active site 749927007750 substrate binding sites [chemical binding]; other site 749927007751 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 749927007752 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 749927007753 active site 749927007754 GIY-YIG motif/motif A; other site 749927007755 catalytic site [active] 749927007756 putative DNA binding site [nucleotide binding]; other site 749927007757 metal binding site [ion binding]; metal-binding site 749927007758 UvrB/uvrC motif; Region: UVR; pfam02151 749927007759 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 749927007760 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 749927007761 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 749927007762 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 749927007763 phosphate binding site [ion binding]; other site 749927007764 putative substrate binding pocket [chemical binding]; other site 749927007765 dimer interface [polypeptide binding]; other site 749927007766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 749927007767 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 749927007768 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 749927007769 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 749927007770 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 749927007771 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 749927007772 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 749927007773 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 749927007774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927007775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927007776 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 749927007777 Ca binding site [ion binding]; other site 749927007778 Ca binding site (active) [ion binding]; other site 749927007779 ligand binding site [chemical binding]; other site 749927007780 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927007781 Interdomain contacts; other site 749927007782 Cytokine receptor motif; other site 749927007783 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927007784 Interdomain contacts; other site 749927007785 Cytokine receptor motif; other site 749927007786 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 749927007787 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 749927007788 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 749927007789 substrate binding site [chemical binding]; other site 749927007790 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl19362 749927007791 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 749927007792 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927007793 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927007794 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927007795 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927007796 dimerization interface [polypeptide binding]; other site 749927007797 putative DNA binding site [nucleotide binding]; other site 749927007798 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 749927007799 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 749927007800 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 749927007801 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 749927007802 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 749927007803 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 749927007804 substrate binding site [chemical binding]; other site 749927007805 hinge regions; other site 749927007806 ADP binding site [chemical binding]; other site 749927007807 catalytic site [active] 749927007808 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 749927007809 substrate binding site [chemical binding]; other site 749927007810 dimer interface [polypeptide binding]; other site 749927007811 catalytic triad [active] 749927007812 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 749927007813 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 749927007814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927007815 Histidine kinase; Region: HisKA_3; pfam07730 749927007816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927007817 ATP binding site [chemical binding]; other site 749927007818 Mg2+ binding site [ion binding]; other site 749927007819 G-X-G motif; other site 749927007820 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 749927007821 putative active site [active] 749927007822 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 749927007823 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 749927007824 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 749927007825 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 749927007826 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 749927007827 Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: Pgi; COG0166 749927007828 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 749927007829 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 749927007830 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 749927007831 putative active site [active] 749927007832 catalytic residue [active] 749927007833 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 749927007834 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 749927007835 TPP-binding site [chemical binding]; other site 749927007836 dimer interface [polypeptide binding]; other site 749927007837 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 749927007838 PYR/PP interface [polypeptide binding]; other site 749927007839 dimer interface [polypeptide binding]; other site 749927007840 TPP binding site [chemical binding]; other site 749927007841 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 749927007842 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 749927007843 putative active site [active] 749927007844 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 749927007845 Part of AAA domain; Region: AAA_19; pfam13245 749927007846 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 749927007847 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 749927007848 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 749927007849 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 749927007850 NADP binding site [chemical binding]; other site 749927007851 dimer interface [polypeptide binding]; other site 749927007852 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927007853 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 749927007854 Di-iron ligands [ion binding]; other site 749927007855 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 749927007856 ABC-2 type transporter; Region: ABC2_membrane; cl17235 749927007857 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927007858 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927007859 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927007860 Walker A/P-loop; other site 749927007861 ATP binding site [chemical binding]; other site 749927007862 Q-loop/lid; other site 749927007863 ABC transporter signature motif; other site 749927007864 Walker B; other site 749927007865 D-loop; other site 749927007866 H-loop/switch region; other site 749927007867 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 749927007868 Predicted transcriptional regulator [Transcription]; Region: COG2345 749927007869 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927007870 putative DNA binding site [nucleotide binding]; other site 749927007871 putative Zn2+ binding site [ion binding]; other site 749927007872 FeS assembly protein SufB; Region: sufB; TIGR01980 749927007873 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 749927007874 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 749927007875 FeS assembly protein SufD; Region: sufD; TIGR01981 749927007876 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 749927007877 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 749927007878 Walker A/P-loop; other site 749927007879 ATP binding site [chemical binding]; other site 749927007880 Q-loop/lid; other site 749927007881 ABC transporter signature motif; other site 749927007882 Walker B; other site 749927007883 D-loop; other site 749927007884 H-loop/switch region; other site 749927007885 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 749927007886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927007887 catalytic residue [active] 749927007888 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 749927007889 trimerization site [polypeptide binding]; other site 749927007890 active site 749927007891 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 749927007892 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 749927007893 hypothetical protein; Provisional; Region: PRK02237 749927007894 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 749927007895 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 749927007896 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 749927007897 active site 749927007898 ATP binding site [chemical binding]; other site 749927007899 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 749927007900 Histidine kinase; Region: HisKA_3; pfam07730 749927007901 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927007902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927007903 active site 749927007904 phosphorylation site [posttranslational modification] 749927007905 intermolecular recognition site; other site 749927007906 dimerization interface [polypeptide binding]; other site 749927007907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927007908 DNA binding residues [nucleotide binding] 749927007909 dimerization interface [polypeptide binding]; other site 749927007910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927007911 S-adenosylmethionine binding site [chemical binding]; other site 749927007912 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927007913 active site 749927007914 metal binding site [ion binding]; metal-binding site 749927007915 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 749927007916 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 749927007917 CysD dimerization site [polypeptide binding]; other site 749927007918 G1 box; other site 749927007919 putative GEF interaction site [polypeptide binding]; other site 749927007920 GTP/Mg2+ binding site [chemical binding]; other site 749927007921 Switch I region; other site 749927007922 G2 box; other site 749927007923 G3 box; other site 749927007924 Switch II region; other site 749927007925 G4 box; other site 749927007926 G5 box; other site 749927007927 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 749927007928 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 749927007929 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 749927007930 ligand-binding site [chemical binding]; other site 749927007931 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 749927007932 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 749927007933 Active Sites [active] 749927007934 SnoaL-like domain; Region: SnoaL_4; pfam13577 749927007935 short chain dehydrogenase; Provisional; Region: PRK07890 749927007936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927007937 NAD(P) binding site [chemical binding]; other site 749927007938 active site 749927007939 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 749927007940 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927007941 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927007942 active site 749927007943 acceptor substrate-binding pocket; other site 749927007944 homodimer interface [polypeptide binding]; other site 749927007945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927007946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927007947 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 749927007948 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 749927007949 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 749927007950 metal binding site [ion binding]; metal-binding site 749927007951 nucleotidyl binding site; other site 749927007952 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927007953 dimerization interface [polypeptide binding]; other site 749927007954 putative DNA binding site [nucleotide binding]; other site 749927007955 putative Zn2+ binding site [ion binding]; other site 749927007956 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 749927007957 putative hydrophobic ligand binding site [chemical binding]; other site 749927007958 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 749927007959 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 749927007960 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 749927007961 Zn2+ binding site [ion binding]; other site 749927007962 Mg2+ binding site [ion binding]; other site 749927007963 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 749927007964 putative active site [active] 749927007965 putative catalytic triad [active] 749927007966 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 749927007967 Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935 749927007968 eRF1 domain 2; Region: eRF1_2; pfam03464 749927007969 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 749927007970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749927007971 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749927007972 Predicted transcriptional regulator [Transcription]; Region: COG4190 749927007973 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927007974 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927007975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927007976 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927007977 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927007978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927007979 Walker A/P-loop; other site 749927007980 ATP binding site [chemical binding]; other site 749927007981 Q-loop/lid; other site 749927007982 ABC transporter signature motif; other site 749927007983 Walker B; other site 749927007984 D-loop; other site 749927007985 H-loop/switch region; other site 749927007986 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927007987 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 749927007988 putative active site [active] 749927007989 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927007990 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927007991 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 749927007992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927007993 S-adenosylmethionine binding site [chemical binding]; other site 749927007994 Transcriptional regulator [Transcription]; Region: LytR; COG1316 749927007995 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927007996 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927007997 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 749927007998 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 749927007999 catalytic triad [active] 749927008000 PAS fold; Region: PAS_4; pfam08448 749927008001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927008002 putative active site [active] 749927008003 heme pocket [chemical binding]; other site 749927008004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927008005 metal binding site [ion binding]; metal-binding site 749927008006 active site 749927008007 I-site; other site 749927008008 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 749927008009 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927008010 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927008011 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 749927008012 nudix motif; other site 749927008013 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 749927008014 dimer interface [polypeptide binding]; other site 749927008015 putative radical transfer pathway; other site 749927008016 diiron center [ion binding]; other site 749927008017 tyrosyl radical; other site 749927008018 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 749927008019 ATP cone domain; Region: ATP-cone; pfam03477 749927008020 Class I ribonucleotide reductase; Region: RNR_I; cd01679 749927008021 active site 749927008022 dimer interface [polypeptide binding]; other site 749927008023 catalytic residues [active] 749927008024 effector binding site; other site 749927008025 R2 peptide binding site; other site 749927008026 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 749927008027 enoyl-CoA hydratase; Provisional; Region: PRK08260 749927008028 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927008029 substrate binding site [chemical binding]; other site 749927008030 oxyanion hole (OAH) forming residues; other site 749927008031 trimer interface [polypeptide binding]; other site 749927008032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927008033 HEAT repeats; Region: HEAT_2; pfam13646 749927008034 TIGR03084 family protein; Region: TIGR03084 749927008035 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 749927008036 Wyosine base formation; Region: Wyosine_form; pfam08608 749927008037 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 749927008038 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927008039 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927008040 active site 749927008041 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 749927008042 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 749927008043 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 749927008044 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 749927008045 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749927008046 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927008047 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 749927008048 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 749927008049 carboxyltransferase (CT) interaction site; other site 749927008050 biotinylation site [posttranslational modification]; other site 749927008051 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927008052 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 749927008053 active site 749927008054 short chain dehydrogenase; Provisional; Region: PRK08278 749927008055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927008056 NAD(P) binding site [chemical binding]; other site 749927008057 active site 749927008058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927008059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008060 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927008061 dimerization interface [polypeptide binding]; other site 749927008062 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 749927008063 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 749927008064 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 749927008065 active site 749927008066 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927008067 metal binding site [ion binding]; metal-binding site 749927008068 active site 749927008069 I-site; other site 749927008070 oxidase reductase; Provisional; Region: PTZ00273 749927008071 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 749927008072 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 749927008073 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 749927008074 nucleoside/Zn binding site; other site 749927008075 dimer interface [polypeptide binding]; other site 749927008076 catalytic motif [active] 749927008077 potential frameshift: common BLAST hit: gi|271962594|ref|YP_003336790.1| DeoR family transcriptional regulator 749927008078 HTH domain; Region: HTH_11; pfam08279 749927008079 WYL domain; Region: WYL; pfam13280 749927008080 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 749927008081 Winged helix DNA-binding domain; Region: HTH_42; cl19833 749927008082 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927008083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008084 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 749927008085 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 749927008086 dimer interface [polypeptide binding]; other site 749927008087 active site 749927008088 CoA binding pocket [chemical binding]; other site 749927008089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927008090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008091 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927008092 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927008093 putative sugar binding sites [chemical binding]; other site 749927008094 Q-X-W motif; other site 749927008095 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 749927008096 active site 749927008097 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 749927008098 Enterobacterial TraT complement resistance protein; Region: TraT; cl19728 749927008099 Domain of unknown function (DUF385); Region: DUF385; pfam04075 749927008100 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927008101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008102 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927008103 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 749927008104 DNA binding residues [nucleotide binding] 749927008105 dimer interface [polypeptide binding]; other site 749927008106 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927008107 Helix-turn-helix domain; Region: HTH_31; pfam13560 749927008108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927008109 AAA ATPase domain; Region: AAA_16; pfam13191 749927008110 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 749927008111 Walker A/P-loop; other site 749927008112 ATP binding site [chemical binding]; other site 749927008113 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 749927008114 structural tetrad; other site 749927008115 FOG: WD40 repeat [General function prediction only]; Region: COG2319 749927008116 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 749927008117 structural tetrad; other site 749927008118 hypothetical protein; Provisional; Region: PRK06847 749927008119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927008120 hypothetical protein; Provisional; Region: PRK06834 749927008121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927008122 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927008123 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 749927008124 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927008125 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927008126 CHAT domain; Region: CHAT; pfam12770 749927008127 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 749927008128 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927008129 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927008130 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927008131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008132 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927008133 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927008134 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 749927008135 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927008136 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927008137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927008138 active site 749927008139 phosphorylation site [posttranslational modification] 749927008140 intermolecular recognition site; other site 749927008141 dimerization interface [polypeptide binding]; other site 749927008142 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927008143 DNA binding residues [nucleotide binding] 749927008144 dimerization interface [polypeptide binding]; other site 749927008145 Histidine kinase; Region: HisKA_3; pfam07730 749927008146 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 749927008147 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927008148 Subtilase family; Region: Peptidase_S8; pfam00082 749927008149 active site 749927008150 catalytic residues [active] 749927008151 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927008152 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927008153 dimerization interface [polypeptide binding]; other site 749927008154 ligand binding site [chemical binding]; other site 749927008155 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 749927008156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927008157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008158 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927008159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008160 short chain dehydrogenase; Provisional; Region: PRK08263 749927008161 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 749927008162 NADP binding site [chemical binding]; other site 749927008163 active site 749927008164 steroid binding site; other site 749927008165 OsmC-like protein; Region: OsmC; cl00767 749927008166 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927008167 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927008168 putative Zn2+ binding site [ion binding]; other site 749927008169 putative DNA binding site [nucleotide binding]; other site 749927008170 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927008171 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 749927008172 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 749927008173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927008174 S-adenosylmethionine binding site [chemical binding]; other site 749927008175 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 749927008176 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927008177 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927008178 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 749927008179 RNA polymerase sigma factor; Provisional; Region: PRK12514 749927008180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927008181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927008182 DNA binding residues [nucleotide binding] 749927008183 putative anti-sigmaE protein; Provisional; Region: PRK13920 749927008184 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 749927008185 Anti-sigma-K factor rskA; Region: RskA; pfam10099 749927008186 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 749927008187 nucleotide binding site [chemical binding]; other site 749927008188 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 749927008189 SulA interaction site; other site 749927008190 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 749927008191 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 749927008192 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749927008193 catalytic residue [active] 749927008194 Protein of unknown function (DUF552); Region: DUF552; cl00775 749927008195 Predicted integral membrane protein [Function unknown]; Region: COG0762 749927008196 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 749927008197 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 749927008198 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 749927008199 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 749927008200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927008201 dimerization interface [polypeptide binding]; other site 749927008202 putative DNA binding site [nucleotide binding]; other site 749927008203 putative Zn2+ binding site [ion binding]; other site 749927008204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927008205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927008206 putative substrate translocation pore; other site 749927008207 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 749927008208 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749927008209 active site 749927008210 HIGH motif; other site 749927008211 nucleotide binding site [chemical binding]; other site 749927008212 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 749927008213 active site 749927008214 KMSKS motif; other site 749927008215 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 749927008216 tRNA binding surface [nucleotide binding]; other site 749927008217 anticodon binding site; other site 749927008218 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 749927008219 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 749927008220 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927008221 dimerization interface [polypeptide binding]; other site 749927008222 putative DNA binding site [nucleotide binding]; other site 749927008223 putative Zn2+ binding site [ion binding]; other site 749927008224 potassium/proton antiporter; Reviewed; Region: PRK05326 749927008225 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 749927008226 TrkA-C domain; Region: TrkA_C; pfam02080 749927008227 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927008228 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927008229 catalytic residue [active] 749927008230 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 749927008231 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 749927008232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749927008233 RNA binding surface [nucleotide binding]; other site 749927008234 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 749927008235 active site 749927008236 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927008237 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 749927008238 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 749927008239 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 749927008240 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 749927008241 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 749927008242 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 749927008243 Fumarylacetoacetase N-terminal; Region: FAA_hydrolase_N; pfam09298 749927008244 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 749927008245 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927008246 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927008247 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 749927008248 active site 749927008249 catalytic site [active] 749927008250 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 749927008251 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 749927008252 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 749927008253 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 749927008254 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 749927008255 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 749927008256 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 749927008257 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927008258 motif II; other site 749927008259 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927008260 dimerization interface [polypeptide binding]; other site 749927008261 putative DNA binding site [nucleotide binding]; other site 749927008262 putative Zn2+ binding site [ion binding]; other site 749927008263 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 749927008264 CoenzymeA binding site [chemical binding]; other site 749927008265 subunit interaction site [polypeptide binding]; other site 749927008266 PHB binding site; other site 749927008267 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927008268 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927008269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927008270 putative DNA binding site [nucleotide binding]; other site 749927008271 putative Zn2+ binding site [ion binding]; other site 749927008272 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 749927008273 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927008274 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927008275 nucleotide binding site [chemical binding]; other site 749927008276 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927008277 Domain of unknown function (DUF427); Region: DUF427; cl00998 749927008278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 749927008279 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 749927008280 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927008281 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 749927008282 Predicted integral membrane protein [Function unknown]; Region: COG5660 749927008283 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 749927008284 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927008285 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927008286 DNA binding residues [nucleotide binding] 749927008287 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 749927008288 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 749927008289 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 749927008290 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 749927008291 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927008292 catalytic loop [active] 749927008293 iron binding site [ion binding]; other site 749927008294 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 749927008295 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927008296 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927008297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927008298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008299 short chain dehydrogenase; Provisional; Region: PRK08263 749927008300 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 749927008301 NADP binding site [chemical binding]; other site 749927008302 active site 749927008303 steroid binding site; other site 749927008304 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927008305 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927008306 active site 749927008307 catalytic tetrad [active] 749927008308 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 749927008309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927008310 Walker A motif; other site 749927008311 ATP binding site [chemical binding]; other site 749927008312 Walker B motif; other site 749927008313 arginine finger; other site 749927008314 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 749927008315 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 749927008316 metal ion-dependent adhesion site (MIDAS); other site 749927008317 adenosine deaminase; Provisional; Region: PRK09358 749927008318 active site 749927008319 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 749927008320 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 749927008321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927008322 ATP binding site [chemical binding]; other site 749927008323 putative Mg++ binding site [ion binding]; other site 749927008324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927008325 nucleotide binding region [chemical binding]; other site 749927008326 ATP-binding site [chemical binding]; other site 749927008327 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 749927008328 HRDC domain; Region: HRDC; pfam00570 749927008329 short chain dehydrogenase; Provisional; Region: PRK12937 749927008330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927008331 NAD(P) binding site [chemical binding]; other site 749927008332 active site 749927008333 transcription termination factor Rho; Provisional; Region: PRK12678 749927008334 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927008335 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 749927008336 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 749927008337 DNA binding residues [nucleotide binding] 749927008338 dimer interface [polypeptide binding]; other site 749927008339 [2Fe-2S] cluster binding site [ion binding]; other site 749927008340 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 749927008341 Sporulation and spore germination; Region: Germane; cl11253 749927008342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927008343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927008344 dimerization interface [polypeptide binding]; other site 749927008345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927008346 dimer interface [polypeptide binding]; other site 749927008347 phosphorylation site [posttranslational modification] 749927008348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927008349 ATP binding site [chemical binding]; other site 749927008350 Mg2+ binding site [ion binding]; other site 749927008351 G-X-G motif; other site 749927008352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927008353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927008354 active site 749927008355 phosphorylation site [posttranslational modification] 749927008356 intermolecular recognition site; other site 749927008357 dimerization interface [polypeptide binding]; other site 749927008358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927008359 DNA binding site [nucleotide binding] 749927008360 PAP2 superfamily; Region: PAP2; pfam01569 749927008361 active site 749927008362 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 749927008363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927008364 catalytic residue [active] 749927008365 hypothetical protein; Provisional; Region: PRK08266 749927008366 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749927008367 PYR/PP interface [polypeptide binding]; other site 749927008368 dimer interface [polypeptide binding]; other site 749927008369 TPP binding site [chemical binding]; other site 749927008370 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927008371 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 749927008372 TPP-binding site [chemical binding]; other site 749927008373 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927008374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927008375 DNA-binding site [nucleotide binding]; DNA binding site 749927008376 FCD domain; Region: FCD; pfam07729 749927008377 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927008378 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927008379 Pirin-related protein [General function prediction only]; Region: COG1741 749927008380 Pirin; Region: Pirin; pfam02678 749927008381 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 749927008382 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 749927008383 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 749927008384 dimer interface [polypeptide binding]; other site 749927008385 ssDNA binding site [nucleotide binding]; other site 749927008386 tetramer (dimer of dimers) interface [polypeptide binding]; other site 749927008387 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 749927008388 Domain of unknown function (DUF385); Region: DUF385; pfam04075 749927008389 Transglycosylase; Region: Transgly; pfam00912 749927008390 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 749927008391 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 749927008392 ABC-2 type transporter; Region: ABC2_membrane; cl17235 749927008393 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927008394 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927008395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927008396 Q-loop/lid; other site 749927008397 ABC transporter signature motif; other site 749927008398 Walker B; other site 749927008399 D-loop; other site 749927008400 H-loop/switch region; other site 749927008401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927008402 Walker A/P-loop; other site 749927008403 ATP binding site [chemical binding]; other site 749927008404 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927008405 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927008406 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927008407 dimerization interface [polypeptide binding]; other site 749927008408 putative DNA binding site [nucleotide binding]; other site 749927008409 putative Zn2+ binding site [ion binding]; other site 749927008410 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 749927008411 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927008412 putative NAD(P) binding site [chemical binding]; other site 749927008413 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 749927008414 dimer interface [polypeptide binding]; other site 749927008415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927008416 Coenzyme A binding pocket [chemical binding]; other site 749927008417 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927008418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927008419 ATP binding site [chemical binding]; other site 749927008420 Mg2+ binding site [ion binding]; other site 749927008421 G-X-G motif; other site 749927008422 Carboxylesterase family; Region: COesterase; pfam00135 749927008423 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 749927008424 substrate binding pocket [chemical binding]; other site 749927008425 catalytic triad [active] 749927008426 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 749927008427 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 749927008428 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 749927008429 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 749927008430 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 749927008431 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 749927008432 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 749927008433 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927008434 catalytic loop [active] 749927008435 iron binding site [ion binding]; other site 749927008436 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 749927008437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927008438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008439 Domain of unknown function (DUF385); Region: DUF385; cl04387 749927008440 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 749927008441 tetrameric interface [polypeptide binding]; other site 749927008442 NAD binding site [chemical binding]; other site 749927008443 catalytic residues [active] 749927008444 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 749927008445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927008446 DNA-binding site [nucleotide binding]; DNA binding site 749927008447 UTRA domain; Region: UTRA; pfam07702 749927008448 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 749927008449 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927008450 NAD binding site [chemical binding]; other site 749927008451 catalytic Zn binding site [ion binding]; other site 749927008452 structural Zn binding site [ion binding]; other site 749927008453 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927008454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927008455 ATP binding site [chemical binding]; other site 749927008456 G-X-G motif; other site 749927008457 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 749927008458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927008459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927008460 ATP binding site [chemical binding]; other site 749927008461 Mg2+ binding site [ion binding]; other site 749927008462 G-X-G motif; other site 749927008463 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 749927008464 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 749927008465 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 749927008466 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927008467 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927008468 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927008469 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 749927008470 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 749927008471 putative dimer interface [polypeptide binding]; other site 749927008472 oxidoreductase; Provisional; Region: PRK06128 749927008473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927008474 NAD(P) binding site [chemical binding]; other site 749927008475 active site 749927008476 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 749927008477 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 749927008478 D-pathway; other site 749927008479 Putative ubiquinol binding site [chemical binding]; other site 749927008480 Low-spin heme (heme b) binding site [chemical binding]; other site 749927008481 Putative water exit pathway; other site 749927008482 Binuclear center (heme o3/CuB) [ion binding]; other site 749927008483 K-pathway; other site 749927008484 Putative proton exit pathway; other site 749927008485 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 749927008486 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 749927008487 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 749927008488 active site 749927008489 catalytic site [active] 749927008490 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 749927008491 dimanganese center [ion binding]; other site 749927008492 Metallopeptidase toxin 3; Region: Tox-MPTase3; pfam15639 749927008493 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927008494 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 749927008495 NADP binding site [chemical binding]; other site 749927008496 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927008497 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927008498 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 749927008499 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 749927008500 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749927008501 active site 749927008502 catalytic triad [active] 749927008503 oxyanion hole [active] 749927008504 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927008505 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927008506 DNA binding site [nucleotide binding] 749927008507 domain linker motif; other site 749927008508 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 749927008509 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927008510 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 749927008511 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927008512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927008513 dimer interface [polypeptide binding]; other site 749927008514 conserved gate region; other site 749927008515 putative PBP binding loops; other site 749927008516 ABC-ATPase subunit interface; other site 749927008517 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927008518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927008519 dimer interface [polypeptide binding]; other site 749927008520 conserved gate region; other site 749927008521 putative PBP binding loops; other site 749927008522 ABC-ATPase subunit interface; other site 749927008523 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 749927008524 legume lectins; Region: lectin_L-type; cl14058 749927008525 homotetramer interaction site [polypeptide binding]; other site 749927008526 hypothetical protein; Provisional; Region: PRK06215 749927008527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927008528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008529 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927008530 active site 749927008531 catalytic tetrad [active] 749927008532 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 749927008533 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 749927008534 conserved cys residue [active] 749927008535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927008536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927008537 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927008538 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927008539 active site 749927008540 catalytic tetrad [active] 749927008541 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 749927008542 dimer interface [polypeptide binding]; other site 749927008543 HTH domain; Region: HTH_11; pfam08279 749927008544 Predicted transcriptional regulator [Transcription]; Region: COG2378 749927008545 WYL domain; Region: WYL; pfam13280 749927008546 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 749927008547 TIGR00268 family protein; Region: TIGR00268 749927008548 Ligand Binding Site [chemical binding]; other site 749927008549 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 749927008550 AIR carboxylase; Region: AIRC; cl00310 749927008551 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 749927008552 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927008553 active site 749927008554 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 749927008555 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 749927008556 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 749927008557 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 749927008558 metal binding site [ion binding]; metal-binding site 749927008559 substrate binding pocket [chemical binding]; other site 749927008560 short chain dehydrogenase; Provisional; Region: PRK06138 749927008561 classical (c) SDRs; Region: SDR_c; cd05233 749927008562 NAD(P) binding site [chemical binding]; other site 749927008563 active site 749927008564 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 749927008565 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 749927008566 ligand binding site [chemical binding]; other site 749927008567 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 749927008568 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927008569 Walker A/P-loop; other site 749927008570 ATP binding site [chemical binding]; other site 749927008571 Q-loop/lid; other site 749927008572 ABC transporter signature motif; other site 749927008573 Walker B; other site 749927008574 D-loop; other site 749927008575 H-loop/switch region; other site 749927008576 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 749927008577 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927008578 TM-ABC transporter signature motif; other site 749927008579 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927008580 active site 749927008581 catalytic tetrad [active] 749927008582 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 749927008583 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 749927008584 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927008585 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927008586 putative sugar binding sites [chemical binding]; other site 749927008587 Q-X-W motif; other site 749927008588 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927008589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927008590 DNA-binding site [nucleotide binding]; DNA binding site 749927008591 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 749927008592 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927008593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008594 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927008595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927008596 DNA binding site [nucleotide binding] 749927008597 domain linker motif; other site 749927008598 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 749927008599 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 749927008600 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 749927008601 ligand binding site [chemical binding]; other site 749927008602 dimerization interface (open form) [polypeptide binding]; other site 749927008603 dimerization interface (closed form) [polypeptide binding]; other site 749927008604 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927008605 acyl-CoA synthetase; Validated; Region: PRK07788 749927008606 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 749927008607 putative AMP binding site [chemical binding]; other site 749927008608 putative active site [active] 749927008609 acyl-activating enzyme (AAE) consensus motif; other site 749927008610 putative CoA binding site [chemical binding]; other site 749927008611 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927008612 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927008613 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927008614 Lsr2; Region: Lsr2; pfam11774 749927008615 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927008616 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927008617 acyl-activating enzyme (AAE) consensus motif; other site 749927008618 AMP binding site [chemical binding]; other site 749927008619 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927008620 Condensation domain; Region: Condensation; pfam00668 749927008621 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927008622 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927008623 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927008624 acyl-activating enzyme (AAE) consensus motif; other site 749927008625 AMP binding site [chemical binding]; other site 749927008626 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927008627 Condensation domain; Region: Condensation; cl19241 749927008628 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927008629 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 749927008630 Condensation domain; Region: Condensation; pfam00668 749927008631 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927008632 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927008633 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927008634 acyl-activating enzyme (AAE) consensus motif; other site 749927008635 AMP binding site [chemical binding]; other site 749927008636 active site 749927008637 CoA binding site [chemical binding]; other site 749927008638 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927008639 Condensation domain; Region: Condensation; cl19241 749927008640 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927008641 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 749927008642 Condensation domain; Region: Condensation; pfam00668 749927008643 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927008644 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927008645 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927008646 acyl-activating enzyme (AAE) consensus motif; other site 749927008647 AMP binding site [chemical binding]; other site 749927008648 active site 749927008649 CoA binding site [chemical binding]; other site 749927008650 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927008651 Condensation domain; Region: Condensation; pfam00668 749927008652 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927008653 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 749927008654 Condensation domain; Region: Condensation; pfam00668 749927008655 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927008656 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927008657 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927008658 acyl-activating enzyme (AAE) consensus motif; other site 749927008659 AMP binding site [chemical binding]; other site 749927008660 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927008661 MbtH-like protein; Region: MbtH; cl01279 749927008662 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927008663 peptide synthase; Provisional; Region: PRK12316 749927008664 Condensation domain; Region: Condensation; pfam00668 749927008665 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927008666 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927008667 acyl-activating enzyme (AAE) consensus motif; other site 749927008668 AMP binding site [chemical binding]; other site 749927008669 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927008670 Condensation domain; Region: Condensation; cl19241 749927008671 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 749927008672 Condensation domain; Region: Condensation; pfam00668 749927008673 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927008674 acyl-activating enzyme (AAE) consensus motif; other site 749927008675 AMP binding site [chemical binding]; other site 749927008676 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927008677 Condensation domain; Region: Condensation; pfam00668 749927008678 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927008679 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927008680 acyl-activating enzyme (AAE) consensus motif; other site 749927008681 AMP binding site [chemical binding]; other site 749927008682 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927008683 Condensation domain; Region: Condensation; cl19241 749927008684 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 749927008685 Condensation domain; Region: Condensation; pfam00668 749927008686 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927008687 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927008688 acyl-activating enzyme (AAE) consensus motif; other site 749927008689 AMP binding site [chemical binding]; other site 749927008690 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927008691 Condensation domain; Region: Condensation; pfam00668 749927008692 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927008693 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927008694 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927008695 acyl-activating enzyme (AAE) consensus motif; other site 749927008696 AMP binding site [chemical binding]; other site 749927008697 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927008698 Condensation domain; Region: Condensation; cl19241 749927008699 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927008700 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 749927008701 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927008702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927008703 putative substrate translocation pore; other site 749927008704 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927008705 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 749927008706 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 749927008707 CGNR zinc finger; Region: zf-CGNR; pfam11706 749927008708 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 749927008709 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927008710 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 749927008711 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927008712 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927008713 putative NAD(P) binding site [chemical binding]; other site 749927008714 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 749927008715 Zn2+ binding site [ion binding]; other site 749927008716 Mg2+ binding site [ion binding]; other site 749927008717 Chitin binding domain; Region: Chitin_bind_3; pfam03067 749927008718 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 749927008719 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 749927008720 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 749927008721 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 749927008722 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 749927008723 Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908 749927008724 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927008725 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927008726 DNA binding residues [nucleotide binding] 749927008727 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 749927008728 putative hydrophobic ligand binding site [chemical binding]; other site 749927008729 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927008730 anti sigma factor interaction site; other site 749927008731 regulatory phosphorylation site [posttranslational modification]; other site 749927008732 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 749927008733 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927008734 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 749927008735 active site 749927008736 metal binding site [ion binding]; metal-binding site 749927008737 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 749927008738 active site 749927008739 catalytic triad [active] 749927008740 oxyanion hole [active] 749927008741 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927008742 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927008743 NAD(P) binding site [chemical binding]; other site 749927008744 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 749927008745 classical (c) SDRs; Region: SDR_c; cd05233 749927008746 NAD(P) binding site [chemical binding]; other site 749927008747 active site 749927008748 short chain dehydrogenase; Region: adh_short; pfam00106 749927008749 classical (c) SDRs; Region: SDR_c; cd05233 749927008750 NAD(P) binding site [chemical binding]; other site 749927008751 active site 749927008752 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 749927008753 enoyl-CoA hydratase; Provisional; Region: PRK06210 749927008754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927008755 substrate binding site [chemical binding]; other site 749927008756 oxyanion hole (OAH) forming residues; other site 749927008757 trimer interface [polypeptide binding]; other site 749927008758 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 749927008759 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927008760 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927008761 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927008762 potential frameshift: common BLAST hit: gi|111018496|ref|YP_701468.1| long-chain-fatty-acid--CoA ligase 749927008763 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927008764 AMP-binding enzyme; Region: AMP-binding; pfam00501 749927008765 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927008766 acyl-activating enzyme (AAE) consensus motif; other site 749927008767 AMP binding site [chemical binding]; other site 749927008768 active site 749927008769 CoA binding site [chemical binding]; other site 749927008770 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 749927008771 active site 749927008772 substrate binding pocket [chemical binding]; other site 749927008773 homodimer interaction site [polypeptide binding]; other site 749927008774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927008775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008776 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927008777 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927008778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927008779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927008780 active site 749927008781 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927008782 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 749927008783 active site 749927008784 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927008785 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927008786 active site 749927008787 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 749927008788 putative active site [active] 749927008789 putative substrate binding site [chemical binding]; other site 749927008790 ATP binding site [chemical binding]; other site 749927008791 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 749927008792 putative active site [active] 749927008793 putative catalytic site [active] 749927008794 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927008795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927008796 NAD(P) binding site [chemical binding]; other site 749927008797 active site 749927008798 galactonate dehydratase; Provisional; Region: PRK14017 749927008799 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 749927008800 active site pocket [active] 749927008801 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927008802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 749927008803 DNA-binding site [nucleotide binding]; DNA binding site 749927008804 FCD domain; Region: FCD; pfam07729 749927008805 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927008806 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927008807 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927008808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927008809 dimer interface [polypeptide binding]; other site 749927008810 conserved gate region; other site 749927008811 putative PBP binding loops; other site 749927008812 ABC-ATPase subunit interface; other site 749927008813 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927008814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927008815 dimer interface [polypeptide binding]; other site 749927008816 conserved gate region; other site 749927008817 putative PBP binding loops; other site 749927008818 ABC-ATPase subunit interface; other site 749927008819 hypothetical protein; Validated; Region: PRK08245 749927008820 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927008821 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927008822 active site 749927008823 ATP binding site [chemical binding]; other site 749927008824 substrate binding site [chemical binding]; other site 749927008825 activation loop (A-loop); other site 749927008826 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927008827 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927008828 DNA binding site [nucleotide binding] 749927008829 Bacterial transcriptional activator domain; Region: BTAD; smart01043 749927008830 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cd13956 749927008831 putative active site [active] 749927008832 Histidine kinase; Region: HisKA_3; pfam07730 749927008833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927008834 ATP binding site [chemical binding]; other site 749927008835 Mg2+ binding site [ion binding]; other site 749927008836 G-X-G motif; other site 749927008837 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927008838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927008839 active site 749927008840 phosphorylation site [posttranslational modification] 749927008841 intermolecular recognition site; other site 749927008842 dimerization interface [polypeptide binding]; other site 749927008843 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927008844 DNA binding residues [nucleotide binding] 749927008845 dimerization interface [polypeptide binding]; other site 749927008846 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 749927008847 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 749927008848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927008849 putative substrate translocation pore; other site 749927008850 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 749927008851 Zn binding site [ion binding]; other site 749927008852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927008853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927008854 dimerization interface [polypeptide binding]; other site 749927008855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927008856 dimer interface [polypeptide binding]; other site 749927008857 phosphorylation site [posttranslational modification] 749927008858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927008859 ATP binding site [chemical binding]; other site 749927008860 Mg2+ binding site [ion binding]; other site 749927008861 G-X-G motif; other site 749927008862 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927008863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927008864 active site 749927008865 phosphorylation site [posttranslational modification] 749927008866 intermolecular recognition site; other site 749927008867 dimerization interface [polypeptide binding]; other site 749927008868 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927008869 DNA binding site [nucleotide binding] 749927008870 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927008871 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927008872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927008873 Walker A/P-loop; other site 749927008874 ATP binding site [chemical binding]; other site 749927008875 Q-loop/lid; other site 749927008876 ABC transporter signature motif; other site 749927008877 Walker B; other site 749927008878 D-loop; other site 749927008879 H-loop/switch region; other site 749927008880 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 749927008881 AAA ATPase domain; Region: AAA_16; pfam13191 749927008882 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927008883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927008884 NAD(P) binding site [chemical binding]; other site 749927008885 active site 749927008886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927008887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927008888 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927008889 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 749927008890 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 749927008891 Walker A/P-loop; other site 749927008892 ATP binding site [chemical binding]; other site 749927008893 Q-loop/lid; other site 749927008894 ABC transporter signature motif; other site 749927008895 Walker B; other site 749927008896 D-loop; other site 749927008897 H-loop/switch region; other site 749927008898 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 749927008899 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 749927008900 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 749927008901 nucleotide binding pocket [chemical binding]; other site 749927008902 K-X-D-G motif; other site 749927008903 catalytic site [active] 749927008904 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 749927008905 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 749927008906 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 749927008907 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 749927008908 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 749927008909 Dimer interface [polypeptide binding]; other site 749927008910 BRCT sequence motif; other site 749927008911 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 749927008912 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 749927008913 catalytic residues [active] 749927008914 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 749927008915 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927008916 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927008917 DNA binding residues [nucleotide binding] 749927008918 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 749927008919 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927008920 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927008921 HTH domain; Region: HTH_11; pfam08279 749927008922 Predicted transcriptional regulator [Transcription]; Region: COG2378 749927008923 WYL domain; Region: WYL; pfam13280 749927008924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927008925 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927008926 putative substrate translocation pore; other site 749927008927 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 749927008928 tetramer interface [polypeptide binding]; other site 749927008929 active site 749927008930 Mg2+/Mn2+ binding site [ion binding]; other site 749927008931 TIGR03086 family protein; Region: TIGR03086 749927008932 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 749927008933 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927008934 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927008935 DNA binding residues [nucleotide binding] 749927008936 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 749927008937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927008938 dimerization interface [polypeptide binding]; other site 749927008939 putative Zn2+ binding site [ion binding]; other site 749927008940 putative DNA binding site [nucleotide binding]; other site 749927008941 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 749927008942 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 749927008943 active site 749927008944 catalytic site [active] 749927008945 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 749927008946 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 749927008947 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 749927008948 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 749927008949 putative ligand binding site [chemical binding]; other site 749927008950 putative NAD binding site [chemical binding]; other site 749927008951 catalytic site [active] 749927008952 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927008953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927008954 dimer interface [polypeptide binding]; other site 749927008955 conserved gate region; other site 749927008956 putative PBP binding loops; other site 749927008957 ABC-ATPase subunit interface; other site 749927008958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927008959 dimer interface [polypeptide binding]; other site 749927008960 conserved gate region; other site 749927008961 putative PBP binding loops; other site 749927008962 ABC-ATPase subunit interface; other site 749927008963 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927008964 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927008965 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 749927008966 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 749927008967 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 749927008968 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927008969 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927008970 dimerization interface [polypeptide binding]; other site 749927008971 ligand binding site [chemical binding]; other site 749927008972 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927008973 active site 749927008974 ATP binding site [chemical binding]; other site 749927008975 substrate binding site [chemical binding]; other site 749927008976 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927008977 substrate binding site [chemical binding]; other site 749927008978 activation loop (A-loop); other site 749927008979 activation loop (A-loop); other site 749927008980 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927008981 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927008982 DNA binding site [nucleotide binding] 749927008983 domain linker motif; other site 749927008984 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927008985 dimerization interface [polypeptide binding]; other site 749927008986 ligand binding site [chemical binding]; other site 749927008987 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927008988 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927008989 active site 749927008990 ATP binding site [chemical binding]; other site 749927008991 substrate binding site [chemical binding]; other site 749927008992 activation loop (A-loop); other site 749927008993 Cellulose binding domain; Region: CBM_2; pfam00553 749927008994 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927008995 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927008996 active site 749927008997 ATP binding site [chemical binding]; other site 749927008998 substrate binding site [chemical binding]; other site 749927008999 activation loop (A-loop); other site 749927009000 Cellulose binding domain; Region: CBM_2; pfam00553 749927009001 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927009002 anti sigma factor interaction site; other site 749927009003 regulatory phosphorylation site [posttranslational modification]; other site 749927009004 Polysulphide reductase, NrfD; Region: NrfD; cl19193 749927009005 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 749927009006 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 749927009007 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 749927009008 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749927009009 molybdopterin cofactor binding site; other site 749927009010 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 749927009011 molybdopterin cofactor binding site; other site 749927009012 benzoate transport; Region: 2A0115; TIGR00895 749927009013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927009014 putative substrate translocation pore; other site 749927009015 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927009016 anti sigma factor interaction site; other site 749927009017 regulatory phosphorylation site [posttranslational modification]; other site 749927009018 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927009019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927009020 S-adenosylmethionine binding site [chemical binding]; other site 749927009021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927009022 non-specific DNA binding site [nucleotide binding]; other site 749927009023 salt bridge; other site 749927009024 sequence-specific DNA binding site [nucleotide binding]; other site 749927009025 Cupin domain; Region: Cupin_2; pfam07883 749927009026 Homeodomain-like domain; Region: HTH_23; pfam13384 749927009027 Winged helix-turn helix; Region: HTH_29; pfam13551 749927009028 Homeodomain-like domain; Region: HTH_32; pfam13565 749927009029 DDE superfamily endonuclease; Region: DDE_3; cl19249 749927009030 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927009031 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 749927009032 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 749927009033 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 749927009034 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 749927009035 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 749927009036 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 749927009037 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927009038 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 749927009039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927009040 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 749927009041 dimerization interface [polypeptide binding]; other site 749927009042 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 749927009043 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 749927009044 putative Iron-sulfur protein interface [polypeptide binding]; other site 749927009045 proximal heme binding site [chemical binding]; other site 749927009046 distal heme binding site [chemical binding]; other site 749927009047 putative dimer interface [polypeptide binding]; other site 749927009048 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 749927009049 L-aspartate oxidase; Provisional; Region: PRK06175 749927009050 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 749927009051 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 749927009052 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 749927009053 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 749927009054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927009055 dimerization interface [polypeptide binding]; other site 749927009056 putative DNA binding site [nucleotide binding]; other site 749927009057 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927009058 putative Zn2+ binding site [ion binding]; other site 749927009059 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927009060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927009061 putative substrate translocation pore; other site 749927009062 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 749927009063 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 749927009064 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927009065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927009066 putative DNA binding site [nucleotide binding]; other site 749927009067 putative Zn2+ binding site [ion binding]; other site 749927009068 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 749927009069 Phosphoesterase family; Region: Phosphoesterase; pfam04185 749927009070 Domain of unknown function (DUF756); Region: DUF756; pfam05506 749927009071 Domain of unknown function (DUF756); Region: DUF756; pfam05506 749927009072 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 749927009073 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 749927009074 O-methyltransferase; Region: Methyltransf_2; pfam00891 749927009075 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927009076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927009077 non-specific DNA binding site [nucleotide binding]; other site 749927009078 salt bridge; other site 749927009079 sequence-specific DNA binding site [nucleotide binding]; other site 749927009080 Cupin domain; Region: Cupin_2; cl17218 749927009081 FAD dependent oxidoreductase; Region: DAO; pfam01266 749927009082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927009083 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 749927009084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 749927009085 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 749927009086 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 749927009087 inhibitor site; inhibition site 749927009088 active site 749927009089 dimer interface [polypeptide binding]; other site 749927009090 catalytic residue [active] 749927009091 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 749927009092 Proline racemase; Region: Pro_racemase; pfam05544 749927009093 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927009094 active site 749927009095 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 749927009096 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 749927009097 ligand binding site [chemical binding]; other site 749927009098 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 749927009099 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 749927009100 ligand binding site [chemical binding]; other site 749927009101 flexible hinge region; other site 749927009102 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 749927009103 substrate binding pocket [chemical binding]; other site 749927009104 substrate-Mg2+ binding site; other site 749927009105 aspartate-rich region 1; other site 749927009106 aspartate-rich region 2; other site 749927009107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927009108 S-adenosylmethionine binding site [chemical binding]; other site 749927009109 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927009110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927009111 dimer interface [polypeptide binding]; other site 749927009112 conserved gate region; other site 749927009113 ABC-ATPase subunit interface; other site 749927009114 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927009115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927009116 dimer interface [polypeptide binding]; other site 749927009117 conserved gate region; other site 749927009118 putative PBP binding loops; other site 749927009119 ABC-ATPase subunit interface; other site 749927009120 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927009121 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927009122 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 749927009123 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 749927009124 U5 snRNP spliceosome subunit [RNA processing and modification]; Region: PRP8; COG5178 749927009125 Domain of unknown function DUF20; Region: UPF0118; cl00465 749927009126 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 749927009127 active site 749927009128 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 749927009129 active site 749927009130 DNA binding site [nucleotide binding] 749927009131 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 749927009132 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 749927009133 DNA binding site [nucleotide binding] 749927009134 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 749927009135 nucleotide binding site [chemical binding]; other site 749927009136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009138 Probable pheophorbidase; Region: PLN02965; cl17657 749927009139 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927009140 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749927009141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927009142 S-adenosylmethionine binding site [chemical binding]; other site 749927009143 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 749927009144 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 749927009145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927009146 motif II; other site 749927009147 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 749927009148 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 749927009149 Flagellar L-ring protein; Region: FlgH; cl19182 749927009150 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 749927009151 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 749927009152 active site 749927009153 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 749927009154 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927009155 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927009156 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 749927009157 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927009158 acyl-activating enzyme (AAE) consensus motif; other site 749927009159 AMP binding site [chemical binding]; other site 749927009160 active site 749927009161 CoA binding site [chemical binding]; other site 749927009162 enoyl-CoA hydratase; Provisional; Region: PRK08150 749927009163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927009164 substrate binding site [chemical binding]; other site 749927009165 oxyanion hole (OAH) forming residues; other site 749927009166 trimer interface [polypeptide binding]; other site 749927009167 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927009168 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 749927009169 acyl-activating enzyme (AAE) consensus motif; other site 749927009170 AMP binding site [chemical binding]; other site 749927009171 active site 749927009172 CoA binding site [chemical binding]; other site 749927009173 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 749927009174 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 749927009175 catalytic Zn binding site [ion binding]; other site 749927009176 NAD binding site [chemical binding]; other site 749927009177 structural Zn binding site [ion binding]; other site 749927009178 aldehyde dehydrogenase family 2 member; Region: PLN02466 749927009179 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 749927009180 NAD(P) binding site [chemical binding]; other site 749927009181 catalytic residues [active] 749927009182 BNR repeat-like domain; Region: BNR_2; pfam13088 749927009183 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 749927009184 Asp-box motif; other site 749927009185 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927009186 anti sigma factor interaction site; other site 749927009187 regulatory phosphorylation site [posttranslational modification]; other site 749927009188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927009189 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927009190 NAD(P) binding site [chemical binding]; other site 749927009191 active site 749927009192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009194 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 749927009195 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 749927009196 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 749927009197 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 749927009198 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 749927009199 active site 749927009200 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 749927009201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927009202 ATP binding site [chemical binding]; other site 749927009203 Mg2+ binding site [ion binding]; other site 749927009204 G-X-G motif; other site 749927009205 SET domain; Region: SET; cl02566 749927009206 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927009207 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927009208 acyl-activating enzyme (AAE) consensus motif; other site 749927009209 AMP binding site [chemical binding]; other site 749927009210 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 749927009211 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 749927009212 putative trimer interface [polypeptide binding]; other site 749927009213 putative CoA binding site [chemical binding]; other site 749927009214 Cellulose binding domain; Region: CBM_2; pfam00553 749927009215 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 749927009216 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 749927009217 active site 749927009218 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 749927009219 substrate binding site [chemical binding]; other site 749927009220 active site 749927009221 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 749927009222 metal binding site [ion binding]; metal-binding site 749927009223 ligand binding site [chemical binding]; other site 749927009224 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 749927009225 Cellulose binding domain; Region: CBM_2; pfam00553 749927009226 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 749927009227 active site 749927009228 catalytic triad [active] 749927009229 oxyanion hole [active] 749927009230 Cellulose binding domain; Region: CBM_2; pfam00553 749927009231 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 749927009232 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 749927009233 active site 749927009234 catalytic triad [active] 749927009235 oxyanion hole [active] 749927009236 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927009237 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927009238 putative sugar binding sites [chemical binding]; other site 749927009239 Q-X-W motif; other site 749927009240 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 749927009241 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 749927009242 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927009243 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927009244 putative sugar binding sites [chemical binding]; other site 749927009245 Q-X-W motif; other site 749927009246 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 749927009247 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927009248 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927009249 putative sugar binding sites [chemical binding]; other site 749927009250 Q-X-W motif; other site 749927009251 Right handed beta helix region; Region: Beta_helix; pfam13229 749927009252 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927009253 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927009254 putative sugar binding sites [chemical binding]; other site 749927009255 Q-X-W motif; other site 749927009256 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927009257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927009258 DNA-binding site [nucleotide binding]; DNA binding site 749927009259 FCD domain; Region: FCD; pfam07729 749927009260 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927009261 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927009262 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927009263 putative sugar binding sites [chemical binding]; other site 749927009264 Q-X-W motif; other site 749927009265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927009266 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927009267 DNA binding site [nucleotide binding] 749927009268 domain linker motif; other site 749927009269 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 749927009270 putative dimerization interface [polypeptide binding]; other site 749927009271 putative ligand binding site [chemical binding]; other site 749927009272 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927009273 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927009274 putative sugar binding sites [chemical binding]; other site 749927009275 Q-X-W motif; other site 749927009276 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 749927009277 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 749927009278 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927009279 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927009280 putative sugar binding sites [chemical binding]; other site 749927009281 Q-X-W motif; other site 749927009282 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 749927009283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009287 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927009288 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927009289 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927009290 DNA binding residues [nucleotide binding] 749927009291 short chain dehydrogenase; Provisional; Region: PRK07109 749927009292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927009293 NAD(P) binding site [chemical binding]; other site 749927009294 active site 749927009295 thiamine pyrophosphate protein; Provisional; Region: PRK08273 749927009296 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 749927009297 PYR/PP interface [polypeptide binding]; other site 749927009298 dimer interface [polypeptide binding]; other site 749927009299 tetramer interface [polypeptide binding]; other site 749927009300 TPP binding site [chemical binding]; other site 749927009301 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927009302 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 749927009303 TPP-binding site [chemical binding]; other site 749927009304 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927009305 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927009306 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 749927009307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927009308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927009309 ATP binding site [chemical binding]; other site 749927009310 Mg2+ binding site [ion binding]; other site 749927009311 G-X-G motif; other site 749927009312 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 749927009313 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927009314 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 749927009315 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 749927009316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927009317 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 749927009318 DNA-binding site [nucleotide binding]; DNA binding site 749927009319 UTRA domain; Region: UTRA; pfam07702 749927009320 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 749927009321 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 749927009322 active site 749927009323 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927009324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927009325 dimer interface [polypeptide binding]; other site 749927009326 conserved gate region; other site 749927009327 putative PBP binding loops; other site 749927009328 ABC-ATPase subunit interface; other site 749927009329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927009330 dimer interface [polypeptide binding]; other site 749927009331 conserved gate region; other site 749927009332 putative PBP binding loops; other site 749927009333 ABC-ATPase subunit interface; other site 749927009334 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927009335 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927009336 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 749927009337 active site 749927009338 catalytic residues [active] 749927009339 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 749927009340 aromatic chitin/cellulose binding site residues [chemical binding]; other site 749927009341 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 749927009342 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927009343 catalytic residue [active] 749927009344 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927009345 active site 749927009346 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927009347 putative DNA binding site [nucleotide binding]; other site 749927009348 putative Zn2+ binding site [ion binding]; other site 749927009349 Low molecular weight phosphatase family; Region: LMWPc; cd00115 749927009350 active site 749927009351 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927009352 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927009353 active site 749927009354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927009355 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927009356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927009357 DNA binding residues [nucleotide binding] 749927009358 dimerization interface [polypeptide binding]; other site 749927009359 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 749927009360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927009361 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927009362 putative substrate translocation pore; other site 749927009363 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927009364 metal binding site [ion binding]; metal-binding site 749927009365 active site 749927009366 I-site; other site 749927009367 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927009368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927009369 DNA binding site [nucleotide binding] 749927009370 domain linker motif; other site 749927009371 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927009372 dimerization interface [polypeptide binding]; other site 749927009373 ligand binding site [chemical binding]; other site 749927009374 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 749927009375 ZIP Zinc transporter; Region: Zip; cl00437 749927009376 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927009377 hydrophobic ligand binding site; other site 749927009378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009380 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 749927009381 active site 749927009382 substrate binding sites [chemical binding]; other site 749927009383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009385 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 749927009386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927009387 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927009388 DNA binding residues [nucleotide binding] 749927009389 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927009390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927009391 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 749927009392 dimerization interface [polypeptide binding]; other site 749927009393 active site 749927009394 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 749927009395 active site 749927009396 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927009397 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 749927009398 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 749927009399 putative substrate binding site [chemical binding]; other site 749927009400 active site 749927009401 serine/threonine protein kinase; Provisional; Region: PRK14879 749927009402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009404 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927009405 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927009406 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927009407 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 749927009408 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927009409 substrate binding pocket [chemical binding]; other site 749927009410 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 749927009411 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 749927009412 synthetase active site [active] 749927009413 NTP binding site [chemical binding]; other site 749927009414 metal binding site [ion binding]; metal-binding site 749927009415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009416 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927009417 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927009418 Protein of unknown function (DUF998); Region: DUF998; pfam06197 749927009419 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 749927009420 active site 749927009421 Zn binding site [ion binding]; other site 749927009422 LysE type translocator; Region: LysE; cl00565 749927009423 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 749927009424 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 749927009425 HSP70 interaction site [polypeptide binding]; other site 749927009426 Nuclease-related domain; Region: NERD; pfam08378 749927009427 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927009428 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 749927009429 acyl-activating enzyme (AAE) consensus motif; other site 749927009430 AMP binding site [chemical binding]; other site 749927009431 active site 749927009432 CoA binding site [chemical binding]; other site 749927009433 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927009434 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 749927009435 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749927009436 substrate binding pocket [chemical binding]; other site 749927009437 membrane-bound complex binding site; other site 749927009438 hinge residues; other site 749927009439 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 749927009440 active site 749927009441 catalytic residues [active] 749927009442 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927009443 MMPL family; Region: MMPL; cl14618 749927009444 MMPL family; Region: MMPL; cl14618 749927009445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927009446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927009447 putative substrate translocation pore; other site 749927009448 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 749927009449 acyl-CoA synthetase; Validated; Region: PRK05850 749927009450 acyl-activating enzyme (AAE) consensus motif; other site 749927009451 active site 749927009452 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927009453 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927009454 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927009455 active site 749927009456 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927009457 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 749927009458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927009459 NAD(P) binding site [chemical binding]; other site 749927009460 short chain dehydrogenase; Region: adh_short; pfam00106 749927009461 active site 749927009462 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927009463 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 749927009464 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 749927009465 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 749927009466 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 749927009467 Putative esterase; Region: Esterase; pfam00756 749927009468 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927009469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 749927009470 Secretory lipase; Region: LIP; pfam03583 749927009471 Cutinase; Region: Cutinase; pfam01083 749927009472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009474 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927009475 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 749927009476 classical (c) SDRs; Region: SDR_c; cd05233 749927009477 NAD(P) binding site [chemical binding]; other site 749927009478 active site 749927009479 short chain dehydrogenase; Provisional; Region: PRK07791 749927009480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927009481 NAD(P) binding site [chemical binding]; other site 749927009482 active site 749927009483 enoyl-CoA hydratase; Provisional; Region: PRK07938 749927009484 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927009485 substrate binding site [chemical binding]; other site 749927009486 oxyanion hole (OAH) forming residues; other site 749927009487 trimer interface [polypeptide binding]; other site 749927009488 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 749927009489 Coenzyme A transferase; Region: CoA_trans; cl17247 749927009490 Nitronate monooxygenase; Region: NMO; pfam03060 749927009491 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 749927009492 FMN binding site [chemical binding]; other site 749927009493 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927009494 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927009495 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 749927009496 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927009497 dimer interface [polypeptide binding]; other site 749927009498 active site 749927009499 short chain dehydrogenase; Provisional; Region: PRK07831 749927009500 classical (c) SDRs; Region: SDR_c; cd05233 749927009501 NAD(P) binding site [chemical binding]; other site 749927009502 active site 749927009503 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927009504 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 749927009505 active site 749927009506 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 749927009507 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 749927009508 acyl-activating enzyme (AAE) consensus motif; other site 749927009509 putative AMP binding site [chemical binding]; other site 749927009510 putative active site [active] 749927009511 putative CoA binding site [chemical binding]; other site 749927009512 enoyl-CoA hydratase; Provisional; Region: PRK08290 749927009513 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927009514 substrate binding site [chemical binding]; other site 749927009515 oxyanion hole (OAH) forming residues; other site 749927009516 trimer interface [polypeptide binding]; other site 749927009517 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927009518 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927009519 active site 749927009520 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927009521 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 749927009522 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927009523 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 749927009524 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927009525 active site 749927009526 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927009527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927009528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 749927009529 Putative zinc-finger; Region: zf-HC2; pfam13490 749927009530 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 749927009531 putative metal binding site [ion binding]; other site 749927009532 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927009533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927009534 DNA-binding site [nucleotide binding]; DNA binding site 749927009535 FCD domain; Region: FCD; pfam07729 749927009536 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 749927009537 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927009538 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 749927009539 active site 749927009540 substrate binding site [chemical binding]; other site 749927009541 Mg2+ binding site [ion binding]; other site 749927009542 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 749927009543 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 749927009544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009546 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927009547 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927009548 NAD(P) binding site [chemical binding]; other site 749927009549 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927009550 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927009551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927009552 dimerization interface [polypeptide binding]; other site 749927009553 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 749927009554 cyclase homology domain; Region: CHD; cd07302 749927009555 nucleotidyl binding site; other site 749927009556 metal binding site [ion binding]; metal-binding site 749927009557 dimer interface [polypeptide binding]; other site 749927009558 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 749927009559 Ferredoxin [Energy production and conversion]; Region: COG1146 749927009560 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 749927009561 4Fe-4S binding domain; Region: Fer4; pfam00037 749927009562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 749927009563 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927009564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009566 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 749927009567 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 749927009568 Mnt; Region: mnt; PHA01513 749927009569 alpha-galactosidase; Region: PLN02808; cl17638 749927009570 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 749927009571 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927009572 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927009573 putative sugar binding sites [chemical binding]; other site 749927009574 Q-X-W motif; other site 749927009575 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927009576 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927009577 DNA binding site [nucleotide binding] 749927009578 domain linker motif; other site 749927009579 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927009580 dimerization interface [polypeptide binding]; other site 749927009581 ligand binding site [chemical binding]; other site 749927009582 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927009583 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927009584 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927009585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927009586 dimer interface [polypeptide binding]; other site 749927009587 conserved gate region; other site 749927009588 putative PBP binding loops; other site 749927009589 ABC-ATPase subunit interface; other site 749927009590 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927009591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927009592 dimer interface [polypeptide binding]; other site 749927009593 conserved gate region; other site 749927009594 putative PBP binding loops; other site 749927009595 ABC-ATPase subunit interface; other site 749927009596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 749927009597 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927009598 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927009599 putative sugar binding sites [chemical binding]; other site 749927009600 Q-X-W motif; other site 749927009601 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 749927009602 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927009603 putative sugar binding sites [chemical binding]; other site 749927009604 Q-X-W motif; other site 749927009605 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927009606 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 749927009607 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 749927009608 Ca binding site [ion binding]; other site 749927009609 Zinc-dependent metalloprotease; Region: ZnMc; smart00235 749927009610 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 749927009611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009613 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 749927009614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927009615 putative substrate translocation pore; other site 749927009616 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 749927009617 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927009618 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927009619 nucleotide binding site [chemical binding]; other site 749927009620 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927009621 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 749927009622 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927009623 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927009624 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927009625 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927009626 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927009627 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927009628 nucleotide binding site [chemical binding]; other site 749927009629 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927009630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927009631 putative substrate translocation pore; other site 749927009632 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927009633 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927009634 DNA binding site [nucleotide binding] 749927009635 domain linker motif; other site 749927009636 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927009637 ligand binding site [chemical binding]; other site 749927009638 dimerization interface [polypeptide binding]; other site 749927009639 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A; Region: PNGaseA; pfam12222 749927009640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927009641 S-adenosylmethionine binding site [chemical binding]; other site 749927009642 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927009643 Protein of unknown function (DUF1152); Region: DUF1152; cl19851 749927009644 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 749927009645 RibD C-terminal domain; Region: RibD_C; pfam01872 749927009646 Alginate lyase; Region: Alginate_lyase2; pfam08787 749927009647 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 749927009648 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 749927009649 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 749927009650 probable active site [active] 749927009651 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927009652 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927009653 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927009654 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 749927009655 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927009656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927009657 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927009658 salt bridge; other site 749927009659 non-specific DNA binding site [nucleotide binding]; other site 749927009660 sequence-specific DNA binding site [nucleotide binding]; other site 749927009661 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927009662 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 749927009663 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927009664 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 749927009665 active site 749927009666 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927009667 NADH(P)-binding; Region: NAD_binding_10; pfam13460 749927009668 NAD(P) binding site [chemical binding]; other site 749927009669 active site 749927009670 acyl-CoA synthetase; Validated; Region: PRK06188 749927009671 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 749927009672 acyl-activating enzyme (AAE) consensus motif; other site 749927009673 putative AMP binding site [chemical binding]; other site 749927009674 putative active site [active] 749927009675 putative CoA binding site [chemical binding]; other site 749927009676 Survival protein SurE; Region: SurE; cl00448 749927009677 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927009678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927009679 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927009680 DNA binding residues [nucleotide binding] 749927009681 Putative zinc-finger; Region: zf-HC2; pfam13490 749927009682 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 749927009683 FOG: PKD repeat [General function prediction only]; Region: COG3291 749927009684 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 749927009685 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 749927009686 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 749927009687 putative NAD(P) binding site [chemical binding]; other site 749927009688 putative substrate binding site [chemical binding]; other site 749927009689 catalytic Zn binding site [ion binding]; other site 749927009690 structural Zn binding site [ion binding]; other site 749927009691 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927009692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927009693 NAD(P) binding site [chemical binding]; other site 749927009694 active site 749927009695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 749927009696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009697 D-glutamate deacylase; Validated; Region: PRK09061 749927009698 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927009699 active site 749927009700 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 749927009701 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 749927009702 metal binding site [ion binding]; metal-binding site 749927009703 dimer interface [polypeptide binding]; other site 749927009704 Uncharacterized conserved protein [Function unknown]; Region: COG3375 749927009705 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 749927009706 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 749927009707 active site 749927009708 octamer interface [polypeptide binding]; other site 749927009709 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927009710 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 749927009711 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 749927009712 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 749927009713 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 749927009714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927009715 dimer interface [polypeptide binding]; other site 749927009716 conserved gate region; other site 749927009717 putative PBP binding loops; other site 749927009718 ABC-ATPase subunit interface; other site 749927009719 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 749927009720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927009721 dimer interface [polypeptide binding]; other site 749927009722 conserved gate region; other site 749927009723 putative PBP binding loops; other site 749927009724 ABC-ATPase subunit interface; other site 749927009725 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 749927009726 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927009727 Walker A/P-loop; other site 749927009728 ATP binding site [chemical binding]; other site 749927009729 Q-loop/lid; other site 749927009730 ABC transporter signature motif; other site 749927009731 Walker B; other site 749927009732 D-loop; other site 749927009733 H-loop/switch region; other site 749927009734 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927009735 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 749927009736 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927009737 Walker A/P-loop; other site 749927009738 ATP binding site [chemical binding]; other site 749927009739 Q-loop/lid; other site 749927009740 ABC transporter signature motif; other site 749927009741 Walker B; other site 749927009742 D-loop; other site 749927009743 H-loop/switch region; other site 749927009744 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927009745 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 749927009746 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 749927009747 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 749927009748 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 749927009749 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927009750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927009751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927009752 putative substrate translocation pore; other site 749927009753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927009756 S-adenosylmethionine binding site [chemical binding]; other site 749927009757 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 749927009758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927009759 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 749927009760 NAD(P) binding site [chemical binding]; other site 749927009761 active site 749927009762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927009763 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927009764 putative substrate translocation pore; other site 749927009765 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927009766 LexA repressor; Validated; Region: PRK00215 749927009767 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 749927009768 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 749927009769 Catalytic site [active] 749927009770 Chitin binding domain; Region: Chitin_bind_3; pfam03067 749927009771 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927009772 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927009773 sequence-specific DNA binding site [nucleotide binding]; other site 749927009774 salt bridge; other site 749927009775 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927009776 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927009777 putative NAD(P) binding site [chemical binding]; other site 749927009778 glycoside hydrolase family 64: beta-1,3-glucanase B (GluB)-like; Region: GH64-GluB-like; cd09220 749927009779 substrate binding pocket [chemical binding]; other site 749927009780 catalytic residues [active] 749927009781 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 749927009782 metal binding site [ion binding]; metal-binding site 749927009783 ligand binding site [chemical binding]; other site 749927009784 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 749927009785 hydrophobic ligand binding site; other site 749927009786 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 749927009787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927009788 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 749927009789 substrate binding site [chemical binding]; other site 749927009790 ATP binding site [chemical binding]; other site 749927009791 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 749927009792 intersubunit interface [polypeptide binding]; other site 749927009793 active site 749927009794 Zn2+ binding site [ion binding]; other site 749927009795 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 749927009796 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 749927009797 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 749927009798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927009799 NAD(P) binding site [chemical binding]; other site 749927009800 active site 749927009801 Predicted permease; Region: DUF318; cl17795 749927009802 TIGR03943 family protein; Region: TIGR03943 749927009803 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749927009804 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927009805 AAA ATPase domain; Region: AAA_16; pfam13191 749927009806 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927009807 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927009808 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927009809 DNA binding residues [nucleotide binding] 749927009810 dimerization interface [polypeptide binding]; other site 749927009811 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 749927009812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927009813 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase; Region: BphB_TodD; TIGR03325 749927009814 NAD(P) binding site [chemical binding]; other site 749927009815 active site 749927009816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009818 acyl-CoA synthetase; Validated; Region: PRK06188 749927009819 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 749927009820 acyl-activating enzyme (AAE) consensus motif; other site 749927009821 putative AMP binding site [chemical binding]; other site 749927009822 putative active site [active] 749927009823 putative CoA binding site [chemical binding]; other site 749927009824 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 749927009825 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 749927009826 classical (c) SDRs; Region: SDR_c; cd05233 749927009827 NAD(P) binding site [chemical binding]; other site 749927009828 active site 749927009829 Phosphopantetheine attachment site; Region: PP-binding; cl09936 749927009830 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 749927009831 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 749927009832 dimer interface [polypeptide binding]; other site 749927009833 active site 749927009834 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927009835 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927009836 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927009837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 749927009838 DNA-binding site [nucleotide binding]; DNA binding site 749927009839 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 749927009840 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 749927009841 substrate binding site [chemical binding]; other site 749927009842 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927009843 hydrophobic ligand binding site; other site 749927009844 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927009845 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 749927009846 NAD(P) binding site [chemical binding]; other site 749927009847 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 749927009848 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927009849 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 749927009850 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927009851 active site 749927009852 metal binding site [ion binding]; metal-binding site 749927009853 AAA ATPase domain; Region: AAA_16; pfam13191 749927009854 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927009855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927009856 DNA binding residues [nucleotide binding] 749927009857 dimerization interface [polypeptide binding]; other site 749927009858 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749927009859 metal-binding site [ion binding] 749927009860 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 749927009861 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749927009862 metal-binding site [ion binding] 749927009863 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 749927009864 Soluble P-type ATPase [General function prediction only]; Region: COG4087 749927009865 Peptidase family M48; Region: Peptidase_M48; cl12018 749927009866 Penicillinase repressor; Region: Penicillinase_R; pfam03965 749927009867 Domain of unknown function (DUF305); Region: DUF305; pfam03713 749927009868 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 749927009869 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 749927009870 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 749927009871 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927009872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927009873 DNA binding residues [nucleotide binding] 749927009874 Putative zinc-finger; Region: zf-HC2; pfam13490 749927009875 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 749927009876 putative hydrophobic ligand binding site [chemical binding]; other site 749927009877 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927009878 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927009879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927009880 TIGR01777 family protein; Region: yfcH 749927009881 NAD(P) binding site [chemical binding]; other site 749927009882 active site 749927009883 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 749927009884 SNF2 Helicase protein; Region: DUF3670; pfam12419 749927009885 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927009886 ATP binding site [chemical binding]; other site 749927009887 putative Mg++ binding site [ion binding]; other site 749927009888 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927009889 nucleotide binding region [chemical binding]; other site 749927009890 ATP-binding site [chemical binding]; other site 749927009891 SWIM zinc finger; Region: SWIM; cl19527 749927009892 AAA domain; Region: AAA_22; pfam13401 749927009893 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 749927009894 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 749927009895 Part of AAA domain; Region: AAA_19; pfam13245 749927009896 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 749927009897 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 749927009898 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 749927009899 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 749927009900 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 749927009901 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 749927009902 enterobactin exporter EntS; Provisional; Region: PRK10489 749927009903 hypothetical protein; Provisional; Region: PRK06185 749927009904 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927009905 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 749927009906 BNR repeat-like domain; Region: BNR_2; pfam13088 749927009907 BNR repeat-like domain; Region: BNR_2; pfam13088 749927009908 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 749927009909 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 749927009910 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 749927009911 active site 749927009912 FMN binding site [chemical binding]; other site 749927009913 substrate binding site [chemical binding]; other site 749927009914 3Fe-4S cluster binding site [ion binding]; other site 749927009915 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927009916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927009917 active site 749927009918 phosphorylation site [posttranslational modification] 749927009919 intermolecular recognition site; other site 749927009920 dimerization interface [polypeptide binding]; other site 749927009921 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927009922 DNA binding site [nucleotide binding] 749927009923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927009924 dimerization interface [polypeptide binding]; other site 749927009925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927009926 dimer interface [polypeptide binding]; other site 749927009927 phosphorylation site [posttranslational modification] 749927009928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927009929 ATP binding site [chemical binding]; other site 749927009930 Mg2+ binding site [ion binding]; other site 749927009931 G-X-G motif; other site 749927009932 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927009933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 749927009934 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 749927009935 Walker A/P-loop; other site 749927009936 ATP binding site [chemical binding]; other site 749927009937 Q-loop/lid; other site 749927009938 ABC transporter signature motif; other site 749927009939 Walker B; other site 749927009940 D-loop; other site 749927009941 H-loop/switch region; other site 749927009942 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 749927009943 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 749927009944 FtsX-like permease family; Region: FtsX; pfam02687 749927009945 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927009946 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927009947 NAD(P) binding site [chemical binding]; other site 749927009948 CGNR zinc finger; Region: zf-CGNR; pfam11706 749927009949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927009950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927009951 putative substrate translocation pore; other site 749927009952 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927009953 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927009954 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927009955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927009956 Histidine kinase; Region: HisKA_3; pfam07730 749927009957 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 749927009958 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927009959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927009960 active site 749927009961 phosphorylation site [posttranslational modification] 749927009962 intermolecular recognition site; other site 749927009963 dimerization interface [polypeptide binding]; other site 749927009964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927009965 DNA binding residues [nucleotide binding] 749927009966 dimerization interface [polypeptide binding]; other site 749927009967 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927009968 CoA-transferase family III; Region: CoA_transf_3; cl19215 749927009969 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927009970 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 749927009971 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 749927009972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927009973 Histidine kinase; Region: HisKA_3; pfam07730 749927009974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927009975 ATP binding site [chemical binding]; other site 749927009976 Mg2+ binding site [ion binding]; other site 749927009977 G-X-G motif; other site 749927009978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927009979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927009980 active site 749927009981 phosphorylation site [posttranslational modification] 749927009982 intermolecular recognition site; other site 749927009983 dimerization interface [polypeptide binding]; other site 749927009984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927009985 salt bridge; other site 749927009986 non-specific DNA binding site [nucleotide binding]; other site 749927009987 sequence-specific DNA binding site [nucleotide binding]; other site 749927009988 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 749927009989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927009990 NAD(P) binding site [chemical binding]; other site 749927009991 active site 749927009992 ribonuclease; Region: Ribonuclease; pfam00545 749927009993 active site 749927009994 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 749927009995 putative hydrophobic ligand binding site [chemical binding]; other site 749927009996 protein interface [polypeptide binding]; other site 749927009997 gate; other site 749927009998 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 749927009999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927010000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010002 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 749927010003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927010004 NAD(P) binding site [chemical binding]; other site 749927010005 active site 749927010006 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 749927010007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927010008 NAD(P) binding site [chemical binding]; other site 749927010009 active site 749927010010 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 749927010011 benzoyl-CoA-dihydrodiol lyase; Region: benzo_boxC; TIGR03222 749927010012 CHAT domain; Region: CHAT; cl19248 749927010013 AAA ATPase domain; Region: AAA_16; pfam13191 749927010014 CHAT domain; Region: CHAT; pfam12770 749927010015 SIR2-like domain; Region: SIR2_2; pfam13289 749927010016 DYW family of nucleic acid deaminases; Region: DYW_deaminase; pfam14432 749927010017 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927010018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927010019 NAD(P) binding site [chemical binding]; other site 749927010020 active site 749927010021 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 749927010022 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927010023 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927010024 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927010025 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl19840 749927010026 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927010027 Ricin-type beta-trefoil; Region: RICIN; smart00458 749927010028 putative sugar binding sites [chemical binding]; other site 749927010029 Q-X-W motif; other site 749927010030 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927010031 putative sugar binding sites [chemical binding]; other site 749927010032 Q-X-W motif; other site 749927010033 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927010034 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927010035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927010036 active site 749927010037 phosphorylation site [posttranslational modification] 749927010038 intermolecular recognition site; other site 749927010039 dimerization interface [polypeptide binding]; other site 749927010040 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927010041 DNA binding site [nucleotide binding] 749927010042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927010043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927010044 dimer interface [polypeptide binding]; other site 749927010045 phosphorylation site [posttranslational modification] 749927010046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927010047 ATP binding site [chemical binding]; other site 749927010048 Mg2+ binding site [ion binding]; other site 749927010049 G-X-G motif; other site 749927010050 Protein of unknown function (DUF1501); Region: DUF1501; cl19855 749927010051 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 749927010052 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 749927010053 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 749927010054 Major royal jelly protein; Region: MRJP; pfam03022 749927010055 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 749927010056 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 749927010057 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 749927010058 NodB motif; other site 749927010059 active site 749927010060 catalytic site [active] 749927010061 metal binding site [ion binding]; metal-binding site 749927010062 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 749927010063 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 749927010064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927010065 ATP binding site [chemical binding]; other site 749927010066 Mg2+ binding site [ion binding]; other site 749927010067 G-X-G motif; other site 749927010068 potential frameshift: common BLAST hit: gi|118471834|ref|YP_889788.1| CheR methyltransferase SAM binding domain-containing protein 749927010069 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927010070 PAS domain; Region: PAS_9; pfam13426 749927010071 putative active site [active] 749927010072 heme pocket [chemical binding]; other site 749927010073 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 749927010074 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 749927010075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927010076 S-adenosylmethionine binding site [chemical binding]; other site 749927010077 PAS domain; Region: PAS_9; pfam13426 749927010078 CheB methylesterase; Region: CheB_methylest; pfam01339 749927010079 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927010080 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927010081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927010082 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927010083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927010085 TPR motif; other site 749927010086 binding surface 749927010087 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927010088 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927010089 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927010090 putative NAD(P) binding site [chemical binding]; other site 749927010091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010093 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 749927010094 alanine dehydrogenase; Region: alaDH; TIGR00518 749927010095 putative active site [active] 749927010096 putative ligand binding site [chemical binding]; other site 749927010097 putative NAD(P) binding site [chemical binding]; other site 749927010098 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 749927010099 active site clefts [active] 749927010100 zinc binding site [ion binding]; other site 749927010101 dimer interface [polypeptide binding]; other site 749927010102 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927010103 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010105 WHG domain; Region: WHG; pfam13305 749927010106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010108 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927010109 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927010110 Cupin domain; Region: Cupin_2; pfam07883 749927010111 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 749927010112 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927010113 anti sigma factor interaction site; other site 749927010114 regulatory phosphorylation site [posttranslational modification]; other site 749927010115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010117 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 749927010118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927010119 NAD(P) binding site [chemical binding]; other site 749927010120 active site 749927010121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927010122 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 749927010123 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 749927010124 WD domain, G-beta repeat; Region: WD40; pfam00400 749927010125 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 749927010126 structural tetrad; other site 749927010127 FOG: WD40 repeat [General function prediction only]; Region: COG2319 749927010128 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 749927010129 structural tetrad; other site 749927010130 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 749927010131 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927010132 DNA binding residues [nucleotide binding] 749927010133 RNA polymerase factor sigma-70; Validated; Region: PRK08241 749927010134 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927010135 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927010136 DNA binding residues [nucleotide binding] 749927010137 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927010138 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927010139 classical (c) SDRs; Region: SDR_c; cd05233 749927010140 NAD(P) binding site [chemical binding]; other site 749927010141 active site 749927010142 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 749927010143 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927010144 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927010145 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 749927010146 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 749927010147 active site 749927010148 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927010149 Peptidase M15; Region: Peptidase_M15_3; cl01194 749927010150 Helix-turn-helix domain; Region: HTH_31; pfam13560 749927010151 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 749927010152 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927010153 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927010154 DNA binding site [nucleotide binding] 749927010155 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927010156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927010157 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927010158 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927010159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927010160 TPR motif; other site 749927010161 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927010162 binding surface 749927010163 AAA ATPase domain; Region: AAA_16; pfam13191 749927010164 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927010165 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927010166 DNA binding residues [nucleotide binding] 749927010167 dimerization interface [polypeptide binding]; other site 749927010168 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 749927010169 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927010170 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 749927010171 active site 749927010172 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; cl19163 749927010173 acyl carrier protein; Provisional; Region: PRK07639 749927010174 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 749927010175 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 749927010176 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749927010177 catalytic residue [active] 749927010178 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927010179 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 749927010180 active site 749927010181 Condensation domain; Region: Condensation; cl19241 749927010182 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927010183 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927010184 Walker A/P-loop; other site 749927010185 ATP binding site [chemical binding]; other site 749927010186 Q-loop/lid; other site 749927010187 ABC transporter signature motif; other site 749927010188 Walker B; other site 749927010189 D-loop; other site 749927010190 H-loop/switch region; other site 749927010191 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 749927010192 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927010193 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 749927010194 Amidinotransferase; Region: Amidinotransf; cl19186 749927010195 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 749927010196 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 749927010197 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 749927010198 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 749927010199 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 749927010200 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 749927010201 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 749927010202 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 749927010203 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927010204 catalytic loop [active] 749927010205 iron binding site [ion binding]; other site 749927010206 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 749927010207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010209 alpha-galactosidase; Region: PLN02808; cl17638 749927010210 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 749927010211 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 749927010212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927010213 Domain of unknown function (DUF385); Region: DUF385; pfam04075 749927010214 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 749927010215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010217 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 749927010218 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927010219 active site 749927010220 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927010221 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927010222 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 749927010223 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 749927010224 classical (c) SDRs; Region: SDR_c; cd05233 749927010225 NAD(P) binding site [chemical binding]; other site 749927010226 active site 749927010227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927010228 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927010229 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927010230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927010231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927010232 DNA binding residues [nucleotide binding] 749927010233 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927010234 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 749927010235 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 749927010236 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 749927010237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010239 WHG domain; Region: WHG; pfam13305 749927010240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010242 WHG domain; Region: WHG; pfam13305 749927010243 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927010244 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927010245 NAD(P) binding site [chemical binding]; other site 749927010246 Protein of unknown function (DUF998); Region: DUF998; pfam06197 749927010247 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 749927010248 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927010249 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927010250 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 749927010251 Bacterial SH3 domain; Region: SH3_3; pfam08239 749927010252 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927010253 dimerization interface [polypeptide binding]; other site 749927010254 putative DNA binding site [nucleotide binding]; other site 749927010255 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927010256 putative Zn2+ binding site [ion binding]; other site 749927010257 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927010258 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927010259 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927010260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927010261 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927010262 dimerization interface [polypeptide binding]; other site 749927010263 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749927010264 catalytic triad [active] 749927010265 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749927010266 active site 749927010267 catalytic triad [active] 749927010268 oxyanion hole [active] 749927010269 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 749927010270 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 749927010271 substrate binding site [chemical binding]; other site 749927010272 active site 749927010273 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 749927010274 active site 749927010275 catalytic triad [active] 749927010276 oxyanion hole [active] 749927010277 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927010278 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927010279 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927010280 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927010281 putative sugar binding sites [chemical binding]; other site 749927010282 Q-X-W motif; other site 749927010283 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927010284 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927010285 active site 749927010286 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927010287 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927010288 Condensation domain; Region: Condensation; pfam00668 749927010289 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927010290 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927010291 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 749927010292 acyl-activating enzyme (AAE) consensus motif; other site 749927010293 AMP binding site [chemical binding]; other site 749927010294 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927010295 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927010296 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927010297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927010298 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927010299 putative substrate translocation pore; other site 749927010300 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927010301 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927010302 acyl-activating enzyme (AAE) consensus motif; other site 749927010303 AMP binding site [chemical binding]; other site 749927010304 active site 749927010305 CoA binding site [chemical binding]; other site 749927010306 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927010307 Condensation domain; Region: Condensation; cl19241 749927010308 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927010309 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927010310 Condensation domain; Region: Condensation; cl19241 749927010311 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927010312 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927010313 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927010314 acyl-activating enzyme (AAE) consensus motif; other site 749927010315 AMP binding site [chemical binding]; other site 749927010316 active site 749927010317 CoA binding site [chemical binding]; other site 749927010318 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927010319 ApbE family; Region: ApbE; pfam02424 749927010320 FMN-binding domain; Region: FMN_bind; cl01081 749927010321 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 749927010322 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 749927010323 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 749927010324 FAD binding pocket [chemical binding]; other site 749927010325 conserved FAD binding motif [chemical binding]; other site 749927010326 phosphate binding motif [ion binding]; other site 749927010327 beta-alpha-beta structure motif; other site 749927010328 NAD binding pocket [chemical binding]; other site 749927010329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927010330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927010331 dimerization interface [polypeptide binding]; other site 749927010332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927010333 dimer interface [polypeptide binding]; other site 749927010334 phosphorylation site [posttranslational modification] 749927010335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927010336 ATP binding site [chemical binding]; other site 749927010337 Mg2+ binding site [ion binding]; other site 749927010338 G-X-G motif; other site 749927010339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927010340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927010341 active site 749927010342 phosphorylation site [posttranslational modification] 749927010343 intermolecular recognition site; other site 749927010344 dimerization interface [polypeptide binding]; other site 749927010345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927010346 DNA binding site [nucleotide binding] 749927010347 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927010348 active site 749927010349 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 749927010350 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927010351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927010352 active site 749927010353 phosphorylation site [posttranslational modification] 749927010354 intermolecular recognition site; other site 749927010355 dimerization interface [polypeptide binding]; other site 749927010356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927010357 DNA binding residues [nucleotide binding] 749927010358 dimerization interface [polypeptide binding]; other site 749927010359 Histidine kinase; Region: HisKA_3; pfam07730 749927010360 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 749927010361 hypothetical protein; Provisional; Region: PRK06184 749927010362 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927010363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927010364 S-adenosylmethionine binding site [chemical binding]; other site 749927010365 potential frameshift: common BLAST hit: gi|290954666|ref|YP_003485848.1| transposase 749927010366 Transposase, Mutator family; Region: Transposase_mut; cl19537 749927010367 Transposase, Mutator family; Region: Transposase_mut; cl19537 749927010368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 749927010369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010371 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 749927010372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927010373 NAD(P) binding site [chemical binding]; other site 749927010374 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927010375 active site 749927010376 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927010377 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 749927010378 putative DNA binding site [nucleotide binding]; other site 749927010379 putative Zn2+ binding site [ion binding]; other site 749927010380 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 749927010381 EamA-like transporter family; Region: EamA; pfam00892 749927010382 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927010383 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927010384 putative NAD(P) binding site [chemical binding]; other site 749927010385 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927010386 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927010387 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 749927010388 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927010389 NADP binding site [chemical binding]; other site 749927010390 active site 749927010391 regulatory binding site [polypeptide binding]; other site 749927010392 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927010393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927010394 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927010395 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927010396 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927010397 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 749927010398 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 749927010399 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927010400 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927010401 putative sugar binding sites [chemical binding]; other site 749927010402 Q-X-W motif; other site 749927010403 Fibronectin type 3 domain; Region: FN3; smart00060 749927010404 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927010405 Interdomain contacts; other site 749927010406 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 749927010407 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 749927010408 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927010409 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 749927010410 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 749927010411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927010412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927010413 putative substrate translocation pore; other site 749927010414 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927010415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927010416 salt bridge; other site 749927010417 non-specific DNA binding site [nucleotide binding]; other site 749927010418 sequence-specific DNA binding site [nucleotide binding]; other site 749927010419 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 749927010420 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 749927010421 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 749927010422 potential frameshift: common BLAST hit: gi|290963139|ref|YP_003494321.1| oxidoreductase, molybdopterin binding subunit 749927010423 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 749927010424 FAD binding domain; Region: FAD_binding_4; cl19922 749927010425 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 749927010426 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927010427 catalytic loop [active] 749927010428 iron binding site [ion binding]; other site 749927010429 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 749927010430 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 749927010431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927010432 putative substrate translocation pore; other site 749927010433 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 749927010434 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927010435 catalytic Zn binding site [ion binding]; other site 749927010436 NAD(P) binding site [chemical binding]; other site 749927010437 structural Zn binding site [ion binding]; other site 749927010438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927010439 salt bridge; other site 749927010440 non-specific DNA binding site [nucleotide binding]; other site 749927010441 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927010442 sequence-specific DNA binding site [nucleotide binding]; other site 749927010443 classical (c) SDRs; Region: SDR_c; cd05233 749927010444 Uncharacterized conserved protein [Function unknown]; Region: COG4925 749927010445 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 749927010446 active site 749927010447 RibD C-terminal domain; Region: RibD_C; cl17279 749927010448 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 749927010449 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 749927010450 active site 749927010451 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 749927010452 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 749927010453 WHG domain; Region: WHG; pfam13305 749927010454 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927010455 dimerization interface [polypeptide binding]; other site 749927010456 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 749927010457 putative active cleft [active] 749927010458 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927010459 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927010460 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927010461 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927010462 nucleotide binding site [chemical binding]; other site 749927010463 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927010464 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 749927010465 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 749927010466 substrate binding site [chemical binding]; other site 749927010467 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 749927010468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927010469 dimer interface [polypeptide binding]; other site 749927010470 conserved gate region; other site 749927010471 putative PBP binding loops; other site 749927010472 ABC-ATPase subunit interface; other site 749927010473 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 749927010474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927010475 dimer interface [polypeptide binding]; other site 749927010476 conserved gate region; other site 749927010477 putative PBP binding loops; other site 749927010478 ABC-ATPase subunit interface; other site 749927010479 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927010480 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 749927010481 Walker A/P-loop; other site 749927010482 ATP binding site [chemical binding]; other site 749927010483 Q-loop/lid; other site 749927010484 ABC transporter signature motif; other site 749927010485 Walker B; other site 749927010486 D-loop; other site 749927010487 H-loop/switch region; other site 749927010488 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927010489 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 749927010490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927010491 Walker A/P-loop; other site 749927010492 ATP binding site [chemical binding]; other site 749927010493 Q-loop/lid; other site 749927010494 ABC transporter signature motif; other site 749927010495 Walker B; other site 749927010496 D-loop; other site 749927010497 H-loop/switch region; other site 749927010498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927010499 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 749927010500 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927010501 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927010502 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927010503 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 749927010504 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927010505 ligand binding site [chemical binding]; other site 749927010506 dimerization interface [polypeptide binding]; other site 749927010507 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927010508 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927010509 putative sugar binding sites [chemical binding]; other site 749927010510 Q-X-W motif; other site 749927010511 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 749927010512 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 749927010513 active site 749927010514 catalytic triad [active] 749927010515 oxyanion hole [active] 749927010516 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927010517 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927010518 putative sugar binding sites [chemical binding]; other site 749927010519 Q-X-W motif; other site 749927010520 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927010521 MarR family; Region: MarR_2; cl17246 749927010522 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927010523 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927010524 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 749927010525 Melibiase; Region: Melibiase; pfam02065 749927010526 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927010527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927010528 active site 749927010529 Cupin; Region: Cupin_6; pfam12852 749927010530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927010531 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 749927010532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927010533 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927010534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010535 hypothetical protein; Provisional; Region: PRK06126 749927010536 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927010537 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 749927010538 active site 749927010539 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 749927010540 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 749927010541 active site 749927010542 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 749927010543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927010544 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927010545 DNA binding residues [nucleotide binding] 749927010546 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 749927010547 iron-sulfur cluster [ion binding]; other site 749927010548 [2Fe-2S] cluster binding site [ion binding]; other site 749927010549 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 749927010550 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 749927010551 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 749927010552 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 749927010553 active site 749927010554 catalytic triad [active] 749927010555 oxyanion hole [active] 749927010556 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927010557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927010558 active site 749927010559 phosphorylation site [posttranslational modification] 749927010560 intermolecular recognition site; other site 749927010561 dimerization interface [polypeptide binding]; other site 749927010562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927010563 DNA binding site [nucleotide binding] 749927010564 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 749927010565 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927010566 dimerization interface [polypeptide binding]; other site 749927010567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927010568 dimer interface [polypeptide binding]; other site 749927010569 phosphorylation site [posttranslational modification] 749927010570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927010571 ATP binding site [chemical binding]; other site 749927010572 Mg2+ binding site [ion binding]; other site 749927010573 G-X-G motif; other site 749927010574 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 749927010575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927010576 AAA domain; Region: AAA_17; pfam13207 749927010577 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927010578 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927010579 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927010580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927010581 DNA binding residues [nucleotide binding] 749927010582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927010583 S-adenosylmethionine binding site [chemical binding]; other site 749927010584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927010585 putative DNA binding site [nucleotide binding]; other site 749927010586 dimerization interface [polypeptide binding]; other site 749927010587 putative Zn2+ binding site [ion binding]; other site 749927010588 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 749927010589 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 749927010590 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927010591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927010592 non-specific DNA binding site [nucleotide binding]; other site 749927010593 salt bridge; other site 749927010594 sequence-specific DNA binding site [nucleotide binding]; other site 749927010595 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 749927010596 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 749927010597 NifU-like domain; Region: NifU; cl00484 749927010598 Acylphosphatase; Region: Acylphosphatase; cl00551 749927010599 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 749927010600 HypF finger; Region: zf-HYPF; pfam07503 749927010601 HypF finger; Region: zf-HYPF; pfam07503 749927010602 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 749927010603 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927010604 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 749927010605 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 749927010606 dimerization interface [polypeptide binding]; other site 749927010607 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 749927010608 ATP binding site [chemical binding]; other site 749927010609 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 749927010610 HupF/HypC family; Region: HupF_HypC; cl00394 749927010611 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 749927010612 nickel binding site [ion binding]; other site 749927010613 NifU-like domain; Region: NifU; cl00484 749927010614 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 749927010615 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 749927010616 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 749927010617 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 749927010618 dimer interface [polypeptide binding]; other site 749927010619 active site 749927010620 HupF/HypC family; Region: HupF_HypC; cl00394 749927010621 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 749927010622 dimer interface [polypeptide binding]; other site 749927010623 active site 749927010624 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927010625 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927010626 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927010627 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927010628 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927010629 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927010630 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 749927010631 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 749927010632 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927010633 RHS Repeat; Region: RHS_repeat; pfam05593 749927010634 RHS Repeat; Region: RHS_repeat; pfam05593 749927010635 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927010636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927010637 NAD(P) binding site [chemical binding]; other site 749927010638 active site 749927010639 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 749927010640 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 749927010641 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 749927010642 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 749927010643 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927010644 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927010645 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 749927010646 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927010647 substrate binding site [chemical binding]; other site 749927010648 oxyanion hole (OAH) forming residues; other site 749927010649 trimer interface [polypeptide binding]; other site 749927010650 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927010651 putative Zn2+ binding site [ion binding]; other site 749927010652 putative DNA binding site [nucleotide binding]; other site 749927010653 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927010654 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927010655 putative NAD(P) binding site [chemical binding]; other site 749927010656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010658 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927010659 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927010660 putative NAD(P) binding site [chemical binding]; other site 749927010661 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927010662 classical (c) SDRs; Region: SDR_c; cd05233 749927010663 NAD(P) binding site [chemical binding]; other site 749927010664 active site 749927010665 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 749927010666 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 749927010667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927010668 NAD(P) binding site [chemical binding]; other site 749927010669 active site 749927010670 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927010671 classical (c) SDRs; Region: SDR_c; cd05233 749927010672 NAD(P) binding site [chemical binding]; other site 749927010673 active site 749927010674 SnoaL-like domain; Region: SnoaL_4; pfam13577 749927010675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010677 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 749927010678 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927010679 acyl-activating enzyme (AAE) consensus motif; other site 749927010680 AMP binding site [chemical binding]; other site 749927010681 active site 749927010682 CoA binding site [chemical binding]; other site 749927010683 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 749927010684 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 749927010685 TM-ABC transporter signature motif; other site 749927010686 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 749927010687 TM-ABC transporter signature motif; other site 749927010688 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 749927010689 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 749927010690 Walker A/P-loop; other site 749927010691 ATP binding site [chemical binding]; other site 749927010692 Q-loop/lid; other site 749927010693 ABC transporter signature motif; other site 749927010694 Walker B; other site 749927010695 D-loop; other site 749927010696 H-loop/switch region; other site 749927010697 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 749927010698 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 749927010699 Walker A/P-loop; other site 749927010700 ATP binding site [chemical binding]; other site 749927010701 Q-loop/lid; other site 749927010702 ABC transporter signature motif; other site 749927010703 Walker B; other site 749927010704 D-loop; other site 749927010705 H-loop/switch region; other site 749927010706 enoyl-CoA hydratase; Provisional; Region: PRK06210 749927010707 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927010708 substrate binding site [chemical binding]; other site 749927010709 oxyanion hole (OAH) forming residues; other site 749927010710 trimer interface [polypeptide binding]; other site 749927010711 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 749927010712 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927010713 active site 749927010714 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927010715 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927010716 acyl-activating enzyme (AAE) consensus motif; other site 749927010717 AMP binding site [chemical binding]; other site 749927010718 active site 749927010719 CoA binding site [chemical binding]; other site 749927010720 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 749927010721 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 749927010722 active site 749927010723 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 749927010724 catalytic triad [active] 749927010725 dimer interface [polypeptide binding]; other site 749927010726 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 749927010727 active site 2 [active] 749927010728 active site 1 [active] 749927010729 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 749927010730 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927010731 substrate binding site [chemical binding]; other site 749927010732 oxyanion hole (OAH) forming residues; other site 749927010733 trimer interface [polypeptide binding]; other site 749927010734 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927010735 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927010736 active site 749927010737 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 749927010738 NAD binding site [chemical binding]; other site 749927010739 catalytic residues [active] 749927010740 Domain of unknown function (DUF222); Region: DUF222; pfam02720 749927010741 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 749927010742 active site 749927010743 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927010744 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 749927010745 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927010746 dimer interface [polypeptide binding]; other site 749927010747 active site 749927010748 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 749927010749 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 749927010750 FMN binding site [chemical binding]; other site 749927010751 substrate binding site [chemical binding]; other site 749927010752 putative catalytic residue [active] 749927010753 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927010754 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 749927010755 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 749927010756 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 749927010757 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 749927010758 tetramerization interface [polypeptide binding]; other site 749927010759 NAD(P) binding site [chemical binding]; other site 749927010760 catalytic residues [active] 749927010761 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 749927010762 CoA binding domain; Region: CoA_binding_2; pfam13380 749927010763 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 749927010764 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 749927010765 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927010766 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 749927010767 active site 749927010768 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 749927010769 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 749927010770 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 749927010771 active site 749927010772 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 749927010773 catalytic triad [active] 749927010774 dimer interface [polypeptide binding]; other site 749927010775 Amidohydrolase; Region: Amidohydro_2; pfam04909 749927010776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927010779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927010780 active site 749927010781 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927010782 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927010783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010784 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 749927010785 DUF35 OB-fold domain; Region: DUF35; pfam01796 749927010786 lipid-transfer protein; Provisional; Region: PRK08256 749927010787 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 749927010788 active site 749927010789 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 749927010790 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 749927010791 NAD binding site [chemical binding]; other site 749927010792 homodimer interface [polypeptide binding]; other site 749927010793 homotetramer interface [polypeptide binding]; other site 749927010794 active site 749927010795 Predicted membrane protein [Function unknown]; Region: COG2259 749927010796 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 749927010797 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927010798 dimer interface [polypeptide binding]; other site 749927010799 active site 749927010800 enoyl-CoA hydratase; Provisional; Region: PRK08252 749927010801 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927010802 substrate binding site [chemical binding]; other site 749927010803 oxyanion hole (OAH) forming residues; other site 749927010804 trimer interface [polypeptide binding]; other site 749927010805 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 749927010806 CoenzymeA binding site [chemical binding]; other site 749927010807 subunit interaction site [polypeptide binding]; other site 749927010808 PHB binding site; other site 749927010809 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 749927010810 short chain dehydrogenase; Provisional; Region: PRK07791 749927010811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927010812 NAD(P) binding site [chemical binding]; other site 749927010813 active site 749927010814 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927010815 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 749927010816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927010817 NAD(P) binding site [chemical binding]; other site 749927010818 active site 749927010819 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 749927010820 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927010821 substrate binding site [chemical binding]; other site 749927010822 oxyanion hole (OAH) forming residues; other site 749927010823 trimer interface [polypeptide binding]; other site 749927010824 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 749927010825 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927010826 substrate binding site [chemical binding]; other site 749927010827 oxyanion hole (OAH) forming residues; other site 749927010828 trimer interface [polypeptide binding]; other site 749927010829 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927010830 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 749927010831 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 749927010832 active site 749927010833 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 749927010834 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927010835 active site 749927010836 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 749927010837 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927010838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927010839 acyl-activating enzyme (AAE) consensus motif; other site 749927010840 acyl-activating enzyme (AAE) consensus motif; other site 749927010841 active site 749927010842 AMP binding site [chemical binding]; other site 749927010843 CoA binding site [chemical binding]; other site 749927010844 lipid-transfer protein; Provisional; Region: PRK07855 749927010845 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 749927010846 active site 749927010847 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 749927010848 DUF35 OB-fold domain; Region: DUF35; pfam01796 749927010849 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 749927010850 putative active site [active] 749927010851 putative catalytic site [active] 749927010852 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927010853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927010854 DNA-binding site [nucleotide binding]; DNA binding site 749927010855 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 749927010856 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927010857 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927010858 active site 749927010859 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 749927010860 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 749927010861 conserved cys residue [active] 749927010862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927010863 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927010864 NAD(P) binding site [chemical binding]; other site 749927010865 catalytic residues [active] 749927010866 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927010867 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927010868 active site 749927010869 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927010870 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 749927010871 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 749927010872 active site 749927010873 enoyl-CoA hydratase; Provisional; Region: PRK08260 749927010874 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927010875 substrate binding site [chemical binding]; other site 749927010876 oxyanion hole (OAH) forming residues; other site 749927010877 trimer interface [polypeptide binding]; other site 749927010878 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927010879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927010880 DNA-binding site [nucleotide binding]; DNA binding site 749927010881 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 749927010882 short chain dehydrogenase; Provisional; Region: PRK06180 749927010883 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 749927010884 NADP binding site [chemical binding]; other site 749927010885 active site 749927010886 steroid binding site; other site 749927010887 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 749927010888 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 749927010889 substrate binding pocket [chemical binding]; other site 749927010890 dimer interface [polypeptide binding]; other site 749927010891 inhibitor binding site; inhibition site 749927010892 acyl-CoA synthetase; Validated; Region: PRK07798 749927010893 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927010894 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927010895 acyl-activating enzyme (AAE) consensus motif; other site 749927010896 acyl-activating enzyme (AAE) consensus motif; other site 749927010897 AMP binding site [chemical binding]; other site 749927010898 active site 749927010899 CoA binding site [chemical binding]; other site 749927010900 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927010901 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927010902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010903 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927010904 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927010905 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927010906 anti sigma factor interaction site; other site 749927010907 regulatory phosphorylation site [posttranslational modification]; other site 749927010908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927010909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927010910 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927010911 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 749927010912 Predicted oxidoreductase [General function prediction only]; Region: COG3573 749927010913 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 749927010914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927010915 sequence-specific DNA binding site [nucleotide binding]; other site 749927010916 salt bridge; other site 749927010917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927010918 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 749927010919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927010920 binding surface 749927010921 TPR motif; other site 749927010922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927010923 TPR motif; other site 749927010924 binding surface 749927010925 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927010926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927010927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927010928 TPR motif; other site 749927010929 binding surface 749927010930 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927010931 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927010932 TIGR03086 family protein; Region: TIGR03086 749927010933 SCP-2 sterol transfer family; Region: SCP2; cl01225 749927010934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 749927010935 MOSC domain; Region: MOSC; pfam03473 749927010936 3-alpha domain; Region: 3-alpha; pfam03475 749927010937 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 749927010938 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 749927010939 FAD binding pocket [chemical binding]; other site 749927010940 FAD binding motif [chemical binding]; other site 749927010941 phosphate binding motif [ion binding]; other site 749927010942 beta-alpha-beta structure motif; other site 749927010943 NAD binding pocket [chemical binding]; other site 749927010944 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927010945 catalytic loop [active] 749927010946 iron binding site [ion binding]; other site 749927010947 dimerization interface [polypeptide binding]; other site 749927010948 putative DNA binding site [nucleotide binding]; other site 749927010949 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 749927010950 putative Zn2+ binding site [ion binding]; other site 749927010951 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927010952 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927010953 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927010954 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 749927010955 potential frameshift: common BLAST hit: gi|262200497|ref|YP_003271705.1| Beta-Ala-His dipeptidase 749927010956 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 749927010957 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 749927010958 metal binding site [ion binding]; metal-binding site 749927010959 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 749927010960 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 749927010961 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 749927010962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927010963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927010964 putative substrate translocation pore; other site 749927010965 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 749927010966 Short C-terminal domain; Region: SHOCT; pfam09851 749927010967 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 749927010968 AAA ATPase domain; Region: AAA_16; pfam13191 749927010969 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927010970 DNA binding residues [nucleotide binding] 749927010971 dimerization interface [polypeptide binding]; other site 749927010972 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 749927010973 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 749927010974 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 749927010975 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927010976 DNA binding residues [nucleotide binding] 749927010977 dimerization interface [polypeptide binding]; other site 749927010978 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 749927010979 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 749927010980 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 749927010981 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927010982 Interdomain contacts; other site 749927010983 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 749927010984 Cytokine receptor motif; other site 749927010985 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 749927010986 alpha-galactosidase; Provisional; Region: PRK15076 749927010987 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 749927010988 NAD binding site [chemical binding]; other site 749927010989 sugar binding site [chemical binding]; other site 749927010990 divalent metal binding site [ion binding]; other site 749927010991 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 749927010992 dimer interface [polypeptide binding]; other site 749927010993 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927010994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927010995 dimer interface [polypeptide binding]; other site 749927010996 conserved gate region; other site 749927010997 putative PBP binding loops; other site 749927010998 ABC-ATPase subunit interface; other site 749927010999 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927011000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927011001 dimer interface [polypeptide binding]; other site 749927011002 conserved gate region; other site 749927011003 putative PBP binding loops; other site 749927011004 ABC-ATPase subunit interface; other site 749927011005 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927011006 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927011007 Glycoside-hydrolase family GH114; Region: Glyco_hydro_114; pfam03537 749927011008 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 749927011009 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927011010 putative DNA binding site [nucleotide binding]; other site 749927011011 putative Zn2+ binding site [ion binding]; other site 749927011012 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 749927011013 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 749927011014 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 749927011015 dimer interface [polypeptide binding]; other site 749927011016 active site 749927011017 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 749927011018 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 749927011019 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 749927011020 EamA-like transporter family; Region: EamA; pfam00892 749927011021 EamA-like transporter family; Region: EamA; pfam00892 749927011022 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 749927011023 ATP binding site [chemical binding]; other site 749927011024 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 749927011025 intersubunit interface [polypeptide binding]; other site 749927011026 active site 749927011027 zinc binding site [ion binding]; other site 749927011028 Na+ binding site [ion binding]; other site 749927011029 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927011030 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927011031 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927011032 putative sugar binding sites [chemical binding]; other site 749927011033 Q-X-W motif; other site 749927011034 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927011035 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927011036 acyl-activating enzyme (AAE) consensus motif; other site 749927011037 AMP binding site [chemical binding]; other site 749927011038 active site 749927011039 CoA binding site [chemical binding]; other site 749927011040 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927011041 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927011042 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927011043 active site 749927011044 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927011045 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 749927011046 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 749927011047 short chain dehydrogenase; Region: adh_short; pfam00106 749927011048 putative NADP binding site [chemical binding]; other site 749927011049 active site 749927011050 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927011051 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927011052 Electron transfer DM13; Region: DM13; pfam10517 749927011053 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927011054 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927011055 NAD(P) binding site [chemical binding]; other site 749927011056 RNA polymerase factor sigma-70; Validated; Region: PRK08241 749927011057 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927011058 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927011059 DNA binding residues [nucleotide binding] 749927011060 endoglucanase; Region: PLN02420 749927011061 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 749927011062 Cellulose binding domain; Region: CBM_3; cl03026 749927011063 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927011064 Interdomain contacts; other site 749927011065 Cytokine receptor motif; other site 749927011066 Cellulose binding domain; Region: CBM_3; pfam00942 749927011067 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 749927011068 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 749927011069 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927011070 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927011071 putative sugar binding sites [chemical binding]; other site 749927011072 Q-X-W motif; other site 749927011073 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 749927011074 active site 749927011075 Ricin-type beta-trefoil; Region: RICIN; smart00458 749927011076 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927011077 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927011078 putative sugar binding sites [chemical binding]; other site 749927011079 Q-X-W motif; other site 749927011080 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 749927011081 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927011082 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 749927011083 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 749927011084 CGNR zinc finger; Region: zf-CGNR; pfam11706 749927011085 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 749927011086 active site 749927011087 substrate binding site [chemical binding]; other site 749927011088 cosubstrate binding site; other site 749927011089 catalytic site [active] 749927011090 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 749927011091 enoyl-CoA hydratase; Provisional; Region: PRK06127 749927011092 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927011093 substrate binding site [chemical binding]; other site 749927011094 oxyanion hole (OAH) forming residues; other site 749927011095 trimer interface [polypeptide binding]; other site 749927011096 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 749927011097 DNA binding site [nucleotide binding] 749927011098 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927011099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927011100 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 749927011101 Catalytic site [active] 749927011102 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927011103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927011104 Walker A/P-loop; other site 749927011105 ATP binding site [chemical binding]; other site 749927011106 Q-loop/lid; other site 749927011107 ABC transporter signature motif; other site 749927011108 Walker B; other site 749927011109 D-loop; other site 749927011110 H-loop/switch region; other site 749927011111 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749927011112 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927011113 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927011114 DNA binding residues [nucleotide binding] 749927011115 acyl-CoA synthetase; Validated; Region: PRK07867 749927011116 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 749927011117 acyl-activating enzyme (AAE) consensus motif; other site 749927011118 putative AMP binding site [chemical binding]; other site 749927011119 putative active site [active] 749927011120 putative CoA binding site [chemical binding]; other site 749927011121 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927011122 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 749927011123 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927011124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927011125 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 749927011126 short chain dehydrogenase; Provisional; Region: PRK12827 749927011127 putative NAD(P) binding site [chemical binding]; other site 749927011128 active site 749927011129 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 749927011130 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 749927011131 active site pocket [active] 749927011132 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927011133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927011134 dimer interface [polypeptide binding]; other site 749927011135 conserved gate region; other site 749927011136 putative PBP binding loops; other site 749927011137 ABC-ATPase subunit interface; other site 749927011138 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 749927011139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927011140 dimer interface [polypeptide binding]; other site 749927011141 conserved gate region; other site 749927011142 putative PBP binding loops; other site 749927011143 ABC-ATPase subunit interface; other site 749927011144 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927011145 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927011146 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927011147 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927011148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927011149 DNA-binding site [nucleotide binding]; DNA binding site 749927011150 FCD domain; Region: FCD; pfam07729 749927011151 Domain of unknown function (DUF718); Region: DUF718; pfam05336 749927011152 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927011153 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927011154 active site 749927011155 TDP-binding site; other site 749927011156 acceptor substrate-binding pocket; other site 749927011157 homodimer interface [polypeptide binding]; other site 749927011158 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927011159 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927011160 active site 749927011161 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927011162 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 749927011163 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 749927011164 active site 749927011165 iron coordination sites [ion binding]; other site 749927011166 substrate binding pocket [chemical binding]; other site 749927011167 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927011168 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927011169 acyl-activating enzyme (AAE) consensus motif; other site 749927011170 AMP binding site [chemical binding]; other site 749927011171 active site 749927011172 CoA binding site [chemical binding]; other site 749927011173 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011174 Condensation domain; Region: Condensation; cl19241 749927011175 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927011176 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927011177 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927011178 acyl-activating enzyme (AAE) consensus motif; other site 749927011179 AMP binding site [chemical binding]; other site 749927011180 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011181 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927011182 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 749927011183 active site 749927011184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927011185 short chain dehydrogenase; Region: adh_short; pfam00106 749927011186 NAD(P) binding site [chemical binding]; other site 749927011187 active site 749927011188 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011189 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927011190 Condensation domain; Region: Condensation; pfam00668 749927011191 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 749927011192 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927011193 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927011194 acyl-activating enzyme (AAE) consensus motif; other site 749927011195 AMP binding site [chemical binding]; other site 749927011196 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011197 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927011198 short chain dehydrogenase; Provisional; Region: PRK07041 749927011199 classical (c) SDRs; Region: SDR_c; cd05233 749927011200 NAD(P) binding site [chemical binding]; other site 749927011201 active site 749927011202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927011203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927011204 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 749927011205 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 749927011206 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927011207 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927011208 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927011209 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927011210 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927011211 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927011212 putative DNA binding site [nucleotide binding]; other site 749927011213 putative Zn2+ binding site [ion binding]; other site 749927011214 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927011215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927011216 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927011217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927011218 dimerization interface [polypeptide binding]; other site 749927011219 putative Zn2+ binding site [ion binding]; other site 749927011220 putative DNA binding site [nucleotide binding]; other site 749927011221 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927011222 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927011223 nucleotide binding site [chemical binding]; other site 749927011224 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927011225 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927011226 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927011227 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 749927011228 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927011229 Walker A/P-loop; other site 749927011230 ATP binding site [chemical binding]; other site 749927011231 Q-loop/lid; other site 749927011232 ABC transporter signature motif; other site 749927011233 Walker B; other site 749927011234 D-loop; other site 749927011235 H-loop/switch region; other site 749927011236 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 749927011237 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927011238 TM-ABC transporter signature motif; other site 749927011239 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 749927011240 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 749927011241 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927011242 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 749927011243 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927011244 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927011245 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 749927011246 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 749927011247 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927011248 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927011249 NAD(P) binding site [chemical binding]; other site 749927011250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927011251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927011252 Probable pheophorbidase; Region: PLN02965; cl17657 749927011253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927011254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927011255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927011256 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 749927011257 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927011258 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927011259 putative sugar binding sites [chemical binding]; other site 749927011260 Q-X-W motif; other site 749927011261 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927011262 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927011263 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927011264 putative sugar binding sites [chemical binding]; other site 749927011265 Q-X-W motif; other site 749927011266 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 749927011267 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl19840 749927011268 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927011269 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927011270 putative sugar binding sites [chemical binding]; other site 749927011271 Q-X-W motif; other site 749927011272 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 749927011273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927011274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927011275 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 749927011276 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 749927011277 Cellulose binding domain; Region: CBM_2; pfam00553 749927011278 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 749927011279 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 749927011280 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 749927011281 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927011282 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927011283 putative sugar binding sites [chemical binding]; other site 749927011284 Q-X-W motif; other site 749927011285 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 749927011286 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927011287 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927011288 putative sugar binding sites [chemical binding]; other site 749927011289 Q-X-W motif; other site 749927011290 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 749927011291 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927011292 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927011293 putative sugar binding sites [chemical binding]; other site 749927011294 Q-X-W motif; other site 749927011295 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 749927011296 active site 749927011297 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 749927011298 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 749927011299 putative NAD(P) binding site [chemical binding]; other site 749927011300 putative substrate binding site [chemical binding]; other site 749927011301 catalytic Zn binding site [ion binding]; other site 749927011302 structural Zn binding site [ion binding]; other site 749927011303 dimer interface [polypeptide binding]; other site 749927011304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927011305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927011306 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 749927011307 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 749927011308 dimer interface [polypeptide binding]; other site 749927011309 acyl-activating enzyme (AAE) consensus motif; other site 749927011310 putative active site [active] 749927011311 AMP binding site [chemical binding]; other site 749927011312 putative CoA binding site [chemical binding]; other site 749927011313 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 749927011314 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927011315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927011316 metabolite-proton symporter; Region: 2A0106; TIGR00883 749927011317 putative substrate translocation pore; other site 749927011318 Tannase and feruloyl esterase; Region: Tannase; pfam07519 749927011319 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 749927011320 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 749927011321 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 749927011322 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 749927011323 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 749927011324 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 749927011325 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 749927011326 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 749927011327 CBD_II domain; Region: CBD_II; smart00637 749927011328 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 749927011329 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927011330 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 749927011331 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 749927011332 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 749927011333 dimer interface [polypeptide binding]; other site 749927011334 active site 749927011335 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 749927011336 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 749927011337 dimer interface [polypeptide binding]; other site 749927011338 active site 749927011339 CoA binding pocket [chemical binding]; other site 749927011340 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 749927011341 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 749927011342 active site 749927011343 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927011344 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927011345 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927011346 acyl-activating enzyme (AAE) consensus motif; other site 749927011347 AMP binding site [chemical binding]; other site 749927011348 active site 749927011349 CoA binding site [chemical binding]; other site 749927011350 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927011351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927011352 NAD(P) binding site [chemical binding]; other site 749927011353 active site 749927011354 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927011355 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927011356 DNA binding site [nucleotide binding] 749927011357 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927011358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927011359 putative substrate translocation pore; other site 749927011360 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927011361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927011362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927011363 dimerization interface [polypeptide binding]; other site 749927011364 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927011365 short chain dehydrogenase; Provisional; Region: PRK06523 749927011366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927011367 NAD(P) binding site [chemical binding]; other site 749927011368 active site 749927011369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927011370 short chain dehydrogenase; Provisional; Region: PRK12828 749927011371 NAD(P) binding site [chemical binding]; other site 749927011372 active site 749927011373 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927011374 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927011375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927011376 non-specific DNA binding site [nucleotide binding]; other site 749927011377 salt bridge; other site 749927011378 sequence-specific DNA binding site [nucleotide binding]; other site 749927011379 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927011380 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927011381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927011382 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927011383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927011384 binding surface 749927011385 TPR motif; other site 749927011386 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927011387 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927011388 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927011389 binding surface 749927011390 TPR motif; other site 749927011391 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 749927011392 active site 749927011393 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 749927011394 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 749927011395 dimer interface [polypeptide binding]; other site 749927011396 active site 749927011397 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749927011398 catalytic residues [active] 749927011399 substrate binding site [chemical binding]; other site 749927011400 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 749927011401 active site 749927011402 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927011403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927011404 active site 749927011405 phosphorylation site [posttranslational modification] 749927011406 intermolecular recognition site; other site 749927011407 dimerization interface [polypeptide binding]; other site 749927011408 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927011409 DNA binding residues [nucleotide binding] 749927011410 dimerization interface [polypeptide binding]; other site 749927011411 Putative sensor; Region: Sensor; pfam13796 749927011412 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927011413 Histidine kinase; Region: HisKA_3; pfam07730 749927011414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927011415 ATP binding site [chemical binding]; other site 749927011416 Mg2+ binding site [ion binding]; other site 749927011417 G-X-G motif; other site 749927011418 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 749927011419 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 749927011420 Walker A/P-loop; other site 749927011421 ATP binding site [chemical binding]; other site 749927011422 Q-loop/lid; other site 749927011423 ABC transporter signature motif; other site 749927011424 Walker B; other site 749927011425 D-loop; other site 749927011426 H-loop/switch region; other site 749927011427 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 749927011428 FtsX-like permease family; Region: FtsX; pfam02687 749927011429 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 749927011430 FtsX-like permease family; Region: FtsX; pfam02687 749927011431 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 749927011432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927011433 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011434 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927011435 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927011436 active site 749927011437 cysteine synthase; Region: PLN02565 749927011438 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 749927011439 dimer interface [polypeptide binding]; other site 749927011440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927011441 catalytic residue [active] 749927011442 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 749927011443 Condensation domain; Region: Condensation; cl19241 749927011444 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927011445 acyl-activating enzyme (AAE) consensus motif; other site 749927011446 AMP binding site [chemical binding]; other site 749927011447 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011448 Condensation domain; Region: Condensation; pfam00668 749927011449 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927011450 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927011451 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927011452 acyl-activating enzyme (AAE) consensus motif; other site 749927011453 AMP binding site [chemical binding]; other site 749927011454 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011455 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 749927011456 Condensation domain; Region: Condensation; pfam00668 749927011457 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927011458 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927011459 active site 749927011460 CoA binding site [chemical binding]; other site 749927011461 AMP binding site [chemical binding]; other site 749927011462 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011463 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 749927011464 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 749927011465 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 749927011466 MbtH-like protein; Region: MbtH; cl01279 749927011467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927011468 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 749927011469 Walker A/P-loop; other site 749927011470 ATP binding site [chemical binding]; other site 749927011471 Q-loop/lid; other site 749927011472 ABC transporter signature motif; other site 749927011473 Walker B; other site 749927011474 D-loop; other site 749927011475 H-loop/switch region; other site 749927011476 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 749927011477 dimer interface [polypeptide binding]; other site 749927011478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927011479 catalytic residue [active] 749927011480 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 749927011481 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 749927011482 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927011483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927011484 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 749927011485 NAD(P) binding site [chemical binding]; other site 749927011486 active site 749927011487 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 749927011488 active site 749927011489 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 749927011490 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 749927011491 dimer interface [polypeptide binding]; other site 749927011492 active site 749927011493 Phosphopantetheine attachment site; Region: PP-binding; cl09936 749927011494 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927011495 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927011496 DNA binding site [nucleotide binding] 749927011497 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927011498 ATP synthase subunit C; Region: ATP-synt_C; cl00466 749927011499 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 749927011500 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 749927011501 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927011502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927011503 dimerization interface [polypeptide binding]; other site 749927011504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927011505 dimer interface [polypeptide binding]; other site 749927011506 phosphorylation site [posttranslational modification] 749927011507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927011508 ATP binding site [chemical binding]; other site 749927011509 Mg2+ binding site [ion binding]; other site 749927011510 G-X-G motif; other site 749927011511 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927011512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927011513 active site 749927011514 phosphorylation site [posttranslational modification] 749927011515 intermolecular recognition site; other site 749927011516 dimerization interface [polypeptide binding]; other site 749927011517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927011518 DNA binding site [nucleotide binding] 749927011519 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927011520 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 749927011521 active site 749927011522 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927011523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927011524 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 749927011525 putative substrate binding pocket [chemical binding]; other site 749927011526 putative dimerization interface [polypeptide binding]; other site 749927011527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927011528 NAD(P) binding site [chemical binding]; other site 749927011529 active site 749927011530 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927011531 metabolite-proton symporter; Region: 2A0106; TIGR00883 749927011532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927011533 putative substrate translocation pore; other site 749927011534 PaaX-like protein; Region: PaaX; pfam07848 749927011535 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 749927011536 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 749927011537 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 749927011538 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927011539 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927011540 FkbH-like domain; Region: FkbH; TIGR01686 749927011541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927011542 active site 749927011543 motif I; other site 749927011544 motif II; other site 749927011545 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927011546 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 749927011547 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 749927011548 active site 749927011549 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011550 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927011551 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927011552 acyl-activating enzyme (AAE) consensus motif; other site 749927011553 AMP binding site [chemical binding]; other site 749927011554 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011555 Condensation domain; Region: Condensation; pfam00668 749927011556 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927011557 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927011558 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 749927011559 acyl-activating enzyme (AAE) consensus motif; other site 749927011560 AMP binding site [chemical binding]; other site 749927011561 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011562 Condensation domain; Region: Condensation; cl19241 749927011563 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 749927011564 Condensation domain; Region: Condensation; pfam00668 749927011565 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927011566 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011567 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927011568 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 749927011569 active site 749927011570 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011571 Condensation domain; Region: Condensation; pfam00668 749927011572 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927011573 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011574 Condensation domain; Region: Condensation; cl19241 749927011575 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 749927011576 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 749927011577 active site 749927011578 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 749927011579 metal ion-dependent adhesion site (MIDAS); other site 749927011580 Calx-beta domain; Region: Calx-beta; pfam03160 749927011581 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 749927011582 Uncharacterized conserved protein [Function unknown]; Region: COG3349 749927011583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927011584 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 749927011585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927011586 S-adenosylmethionine binding site [chemical binding]; other site 749927011587 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 749927011588 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 749927011589 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 749927011590 active site lid residues [active] 749927011591 substrate binding pocket [chemical binding]; other site 749927011592 catalytic residues [active] 749927011593 substrate-Mg2+ binding site; other site 749927011594 aspartate-rich region 1; other site 749927011595 aspartate-rich region 2; other site 749927011596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927011597 phytoene desaturase; Region: crtI_fam; TIGR02734 749927011598 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 749927011599 substrate binding pocket [chemical binding]; other site 749927011600 chain length determination region; other site 749927011601 substrate-Mg2+ binding site; other site 749927011602 catalytic residues [active] 749927011603 aspartate-rich region 1; other site 749927011604 active site lid residues [active] 749927011605 aspartate-rich region 2; other site 749927011606 Protein of unknown function (DUF422); Region: DUF422; cl00991 749927011607 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 749927011608 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 749927011609 active site 749927011610 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927011611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927011612 phytoene desaturase; Region: crtI_fam; TIGR02734 749927011613 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 749927011614 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 749927011615 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927011616 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927011617 DNA binding residues [nucleotide binding] 749927011618 B12 binding domain; Region: B12-binding_2; pfam02607 749927011619 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 749927011620 B12 binding site [chemical binding]; other site 749927011621 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927011622 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927011623 DNA binding residues [nucleotide binding] 749927011624 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 749927011625 B12 binding site [chemical binding]; other site 749927011626 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 749927011627 iron-sulfur cluster [ion binding]; other site 749927011628 [2Fe-2S] cluster binding site [ion binding]; other site 749927011629 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927011630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927011631 dimer interface [polypeptide binding]; other site 749927011632 conserved gate region; other site 749927011633 putative PBP binding loops; other site 749927011634 ABC-ATPase subunit interface; other site 749927011635 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927011636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927011637 dimer interface [polypeptide binding]; other site 749927011638 conserved gate region; other site 749927011639 putative PBP binding loops; other site 749927011640 ABC-ATPase subunit interface; other site 749927011641 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927011642 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927011643 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927011644 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927011645 DNA binding site [nucleotide binding] 749927011646 domain linker motif; other site 749927011647 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927011648 dimerization interface [polypeptide binding]; other site 749927011649 ligand binding site [chemical binding]; other site 749927011650 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927011651 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927011652 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927011653 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927011654 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 749927011655 Cellulose binding domain; Region: CBM_2; pfam00553 749927011656 Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718 749927011657 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927011658 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 749927011659 TIGR03086 family protein; Region: TIGR03086 749927011660 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927011661 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 749927011662 putative hydrophobic ligand binding site [chemical binding]; other site 749927011663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927011664 dimerization interface [polypeptide binding]; other site 749927011665 putative DNA binding site [nucleotide binding]; other site 749927011666 putative Zn2+ binding site [ion binding]; other site 749927011667 Cellulose binding domain; Region: CBM_2; pfam00553 749927011668 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 749927011669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927011670 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927011671 NAD(P) binding site [chemical binding]; other site 749927011672 active site 749927011673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927011674 PAS fold; Region: PAS_3; pfam08447 749927011675 putative active site [active] 749927011676 heme pocket [chemical binding]; other site 749927011677 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 749927011678 PAS domain S-box; Region: sensory_box; TIGR00229 749927011679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927011680 putative active site [active] 749927011681 heme pocket [chemical binding]; other site 749927011682 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927011683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 749927011684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927011685 ATP binding site [chemical binding]; other site 749927011686 Mg2+ binding site [ion binding]; other site 749927011687 G-X-G motif; other site 749927011688 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927011689 anti sigma factor interaction site; other site 749927011690 regulatory phosphorylation site [posttranslational modification]; other site 749927011691 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 749927011692 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927011693 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 749927011694 Alginate lyase; Region: Alginate_lyase2; pfam08787 749927011695 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 749927011696 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 749927011697 dimer interface [polypeptide binding]; other site 749927011698 active site 749927011699 heme binding site [chemical binding]; other site 749927011700 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 749927011701 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 749927011702 metal binding site 2 [ion binding]; metal-binding site 749927011703 putative DNA binding helix; other site 749927011704 metal binding site 1 [ion binding]; metal-binding site 749927011705 dimer interface [polypeptide binding]; other site 749927011706 structural Zn2+ binding site [ion binding]; other site 749927011707 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 749927011708 dimerization interface [polypeptide binding]; other site 749927011709 active site 749927011710 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 749927011711 folate binding site [chemical binding]; other site 749927011712 NADP+ binding site [chemical binding]; other site 749927011713 choline dehydrogenase; Validated; Region: PRK02106 749927011714 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927011715 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927011716 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 749927011717 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 749927011718 NAD(P) binding site [chemical binding]; other site 749927011719 catalytic residues [active] 749927011720 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 749927011721 PLD-like domain; Region: PLDc_2; pfam13091 749927011722 putative active site [active] 749927011723 catalytic site [active] 749927011724 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 749927011725 PLD-like domain; Region: PLDc_2; pfam13091 749927011726 putative active site [active] 749927011727 catalytic site [active] 749927011728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927011729 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 749927011730 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 749927011731 FMN-binding pocket [chemical binding]; other site 749927011732 flavin binding motif; other site 749927011733 phosphate binding motif [ion binding]; other site 749927011734 beta-alpha-beta structure motif; other site 749927011735 NAD binding pocket [chemical binding]; other site 749927011736 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927011737 catalytic loop [active] 749927011738 iron binding site [ion binding]; other site 749927011739 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 749927011740 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 749927011741 iron-sulfur cluster [ion binding]; other site 749927011742 [2Fe-2S] cluster binding site [ion binding]; other site 749927011743 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927011744 hydrophobic ligand binding site; other site 749927011745 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927011746 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 749927011747 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927011748 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 749927011749 homodimer interface [polypeptide binding]; other site 749927011750 putative substrate binding pocket [chemical binding]; other site 749927011751 diiron center [ion binding]; other site 749927011752 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 749927011753 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 749927011754 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 749927011755 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 749927011756 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 749927011757 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 749927011758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927011759 AAA domain; Region: AAA_11; pfam13086 749927011760 AAA domain; Region: AAA_30; pfam13604 749927011761 Walker A motif; other site 749927011762 ATP binding site [chemical binding]; other site 749927011763 AAA domain; Region: AAA_12; pfam13087 749927011764 short chain dehydrogenase; Provisional; Region: PRK07109 749927011765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927011766 NAD(P) binding site [chemical binding]; other site 749927011767 active site 749927011768 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 749927011769 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 749927011770 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 749927011771 putative metal binding site [ion binding]; other site 749927011772 Amino acid permease; Region: AA_permease_2; pfam13520 749927011773 ChaB; Region: ChaB; pfam06150 749927011774 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 749927011775 CheB methylesterase; Region: CheB_methylest; pfam01339 749927011776 CheB methylesterase; Region: CheB_methylest; pfam01339 749927011777 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Region: SpoIIAA; COG1366 749927011778 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 749927011779 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 749927011780 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 749927011781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927011782 S-adenosylmethionine binding site [chemical binding]; other site 749927011783 PAS fold; Region: PAS; pfam00989 749927011784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927011785 putative active site [active] 749927011786 heme pocket [chemical binding]; other site 749927011787 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927011788 PAS domain; Region: PAS_9; pfam13426 749927011789 putative active site [active] 749927011790 heme pocket [chemical binding]; other site 749927011791 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749927011792 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 749927011793 active site 749927011794 nucleotide binding site [chemical binding]; other site 749927011795 HIGH motif; other site 749927011796 KMSKS motif; other site 749927011797 silicon transporter; Region: sit; TIGR00811 749927011798 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 749927011799 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 749927011800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927011801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927011802 ATP binding site [chemical binding]; other site 749927011803 Mg2+ binding site [ion binding]; other site 749927011804 G-X-G motif; other site 749927011805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927011806 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927011807 putative substrate translocation pore; other site 749927011808 Protein of unknown function (DUF1015); Region: DUF1015; cl19858 749927011809 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 749927011810 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927011811 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 749927011812 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 749927011813 active site 749927011814 DNA binding site [nucleotide binding] 749927011815 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 749927011816 DNA binding site [nucleotide binding] 749927011817 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 749927011818 nucleotide binding site [chemical binding]; other site 749927011819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927011820 putative substrate translocation pore; other site 749927011821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927011822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927011823 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 749927011824 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 749927011825 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 749927011826 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 749927011827 active site 749927011828 dimer interface [polypeptide binding]; other site 749927011829 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 749927011830 putative sialic acid transporter; Region: 2A0112; TIGR00891 749927011831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927011832 putative substrate translocation pore; other site 749927011833 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 749927011834 catalytic site [active] 749927011835 BNR repeat-like domain; Region: BNR_2; pfam13088 749927011836 Asp-box motif; other site 749927011837 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 749927011838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927011839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927011840 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927011841 dimerization interface [polypeptide binding]; other site 749927011842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927011843 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 749927011844 dimerization interface [polypeptide binding]; other site 749927011845 substrate binding pocket [chemical binding]; other site 749927011846 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 749927011847 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927011848 putative NAD(P) binding site [chemical binding]; other site 749927011849 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927011850 O-methyltransferase; Region: Methyltransf_2; pfam00891 749927011851 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749927011852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927011853 S-adenosylmethionine binding site [chemical binding]; other site 749927011854 Peptidase M14 Carboxypeptidase T-like subfamily; Region: M14_CPT_like; cd06226 749927011855 putative active site [active] 749927011856 Zn binding site [ion binding]; other site 749927011857 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 749927011858 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749927011859 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927011860 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 749927011861 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 749927011862 carboxyltransferase (CT) interaction site; other site 749927011863 biotinylation site [posttranslational modification]; other site 749927011864 EH_Signature domain; Region: EH_Signature; pfam15611 749927011865 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 749927011866 PHP domain; Region: PHP; pfam02811 749927011867 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 749927011868 active site 749927011869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927011870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927011871 putative substrate translocation pore; other site 749927011872 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 749927011873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927011874 DNA-binding site [nucleotide binding]; DNA binding site 749927011875 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927011876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927011877 homodimer interface [polypeptide binding]; other site 749927011878 catalytic residue [active] 749927011879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927011880 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927011881 putative substrate translocation pore; other site 749927011882 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 749927011883 hydrophobic ligand binding site; other site 749927011884 Bifunctional nuclease; Region: DNase-RNase; pfam02577 749927011885 RNA polymerase factor sigma-70; Validated; Region: PRK08241 749927011886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927011887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927011888 DNA binding residues [nucleotide binding] 749927011889 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927011890 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 749927011891 acyl-CoA synthetase; Validated; Region: PRK05850 749927011892 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 749927011893 acyl-activating enzyme (AAE) consensus motif; other site 749927011894 active site 749927011895 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927011896 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 749927011897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927011898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927011899 S-adenosylmethionine binding site [chemical binding]; other site 749927011900 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 749927011901 Fe binding site [ion binding]; other site 749927011902 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 749927011903 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 749927011904 nucleotide binding site [chemical binding]; other site 749927011905 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 749927011906 substrate binding site [chemical binding]; other site 749927011907 ATP binding site [chemical binding]; other site 749927011908 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 749927011909 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927011910 ATP binding site [chemical binding]; other site 749927011911 putative Mg++ binding site [ion binding]; other site 749927011912 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927011913 nucleotide binding region [chemical binding]; other site 749927011914 ATP-binding site [chemical binding]; other site 749927011915 ANTAR domain; Region: ANTAR; pfam03861 749927011916 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 749927011917 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927011918 GAF domain; Region: GAF; pfam01590 749927011919 ANTAR domain; Region: ANTAR; pfam03861 749927011920 GAF domain; Region: GAF; pfam01590 749927011921 ANTAR domain; Region: ANTAR; pfam03861 749927011922 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 749927011923 nucleotide binding site [chemical binding]; other site 749927011924 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 749927011925 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927011926 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927011927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927011928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927011929 DoxX-like family; Region: DoxX_2; pfam13564 749927011930 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 749927011931 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 749927011932 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 749927011933 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 749927011934 Cupredoxin superfamily; Region: Cupredoxin; cl19115 749927011935 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 749927011936 iron-sulfur cluster [ion binding]; other site 749927011937 [2Fe-2S] cluster binding site [ion binding]; other site 749927011938 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 749927011939 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 749927011940 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927011941 TIGR03086 family protein; Region: TIGR03086 749927011942 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 749927011943 heme-binding site [chemical binding]; other site 749927011944 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 749927011945 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 749927011946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927011947 non-specific DNA binding site [nucleotide binding]; other site 749927011948 salt bridge; other site 749927011949 sequence-specific DNA binding site [nucleotide binding]; other site 749927011950 Cupin domain; Region: Cupin_2; pfam07883 749927011951 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927011952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927011953 Coenzyme A binding pocket [chemical binding]; other site 749927011954 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 749927011955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927011956 non-specific DNA binding site [nucleotide binding]; other site 749927011957 salt bridge; other site 749927011958 sequence-specific DNA binding site [nucleotide binding]; other site 749927011959 Cupin domain; Region: Cupin_2; pfam07883 749927011960 elongation factor Tu; Reviewed; Region: PRK12736 749927011961 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 749927011962 G1 box; other site 749927011963 GEF interaction site [polypeptide binding]; other site 749927011964 GTP/Mg2+ binding site [chemical binding]; other site 749927011965 Switch I region; other site 749927011966 G2 box; other site 749927011967 G3 box; other site 749927011968 Switch II region; other site 749927011969 G4 box; other site 749927011970 G5 box; other site 749927011971 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 749927011972 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 749927011973 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 749927011974 Right handed beta helix region; Region: Beta_helix; pfam13229 749927011975 acetaldehyde dehydrogenase; Validated; Region: PRK08300 749927011976 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 749927011977 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 749927011978 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 749927011979 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 749927011980 active site 749927011981 catalytic residues [active] 749927011982 metal binding site [ion binding]; metal-binding site 749927011983 DmpG-like communication domain; Region: DmpG_comm; pfam07836 749927011984 hypothetical protein; Provisional; Region: PRK06834 749927011985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927011986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927011987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927011988 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 749927011989 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 749927011990 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927011991 LysE type translocator; Region: LysE; cl00565 749927011992 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 749927011993 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 749927011994 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 749927011995 DNA binding site [nucleotide binding] 749927011996 active site 749927011997 Oxygenase, catalyzing oxidative methylation of damaged DNA; Region: Oxygenase-NA; pfam09859 749927011998 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 749927011999 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 749927012000 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 749927012001 DNA binding site [nucleotide binding] 749927012002 active site 749927012003 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927012004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927012005 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927012006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927012007 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 749927012008 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 749927012009 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 749927012010 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927012011 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927012012 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 749927012013 putative DNA binding site [nucleotide binding]; other site 749927012014 putative Zn2+ binding site [ion binding]; other site 749927012015 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927012016 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927012017 inhibitor-cofactor binding pocket; inhibition site 749927012018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927012019 catalytic residue [active] 749927012020 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927012021 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927012022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927012023 active site 749927012024 phosphorylation site [posttranslational modification] 749927012025 dimerization interface [polypeptide binding]; other site 749927012026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927012027 DNA binding residues [nucleotide binding] 749927012028 dimerization interface [polypeptide binding]; other site 749927012029 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927012030 active site 749927012031 catalytic residues [active] 749927012032 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927012033 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927012034 active site 749927012035 ATP binding site [chemical binding]; other site 749927012036 substrate binding site [chemical binding]; other site 749927012037 activation loop (A-loop); other site 749927012038 CBD_II domain; Region: CBD_II; smart00637 749927012039 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 749927012040 active site 749927012041 heat shock protein 90; Provisional; Region: PRK05218 749927012042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927012043 ATP binding site [chemical binding]; other site 749927012044 Mg2+ binding site [ion binding]; other site 749927012045 G-X-G motif; other site 749927012046 Hsp90 protein; Region: HSP90; pfam00183 749927012047 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 749927012048 Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; Region: Amicyanin; cd13921 749927012049 Type 1 (T1) Cu binding site [ion binding]; other site 749927012050 Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; Region: Amicyanin; cd13921 749927012051 Type 1 (T1) Cu binding site [ion binding]; other site 749927012052 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 749927012053 Copper resistance protein D; Region: CopD; cl00563 749927012054 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 749927012055 CopC domain; Region: CopC; pfam04234 749927012056 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927012057 active site 749927012058 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 749927012059 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927012060 DNA binding residues [nucleotide binding] 749927012061 dimer interface [polypeptide binding]; other site 749927012062 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927012063 active site 749927012064 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 749927012065 oxidoreductase; Provisional; Region: PRK12743 749927012066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927012067 NAD(P) binding site [chemical binding]; other site 749927012068 active site 749927012069 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 749927012070 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 749927012071 putative active site [active] 749927012072 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927012073 active site 749927012074 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 749927012075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927012076 active site 749927012077 motif I; other site 749927012078 motif II; other site 749927012079 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 749927012080 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 749927012081 NAD(P) binding site [chemical binding]; other site 749927012082 catalytic residues [active] 749927012083 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 749927012084 translation initiation factor IF-2 subunit beta; Provisional; Region: PRK12336 749927012085 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 749927012086 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 749927012087 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 749927012088 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 749927012089 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 749927012090 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 749927012091 putative active site [active] 749927012092 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 749927012093 classical (c) SDRs; Region: SDR_c; cd05233 749927012094 NAD(P) binding site [chemical binding]; other site 749927012095 active site 749927012096 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 749927012097 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 749927012098 substrate binding site [chemical binding]; other site 749927012099 ATP binding site [chemical binding]; other site 749927012100 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749927012101 active site 749927012102 nucleotide binding site [chemical binding]; other site 749927012103 HIGH motif; other site 749927012104 KMSKS motif; other site 749927012105 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 749927012106 dimer interface [polypeptide binding]; other site 749927012107 active site 749927012108 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 749927012109 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927012110 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 749927012111 NAD binding site [chemical binding]; other site 749927012112 putative substrate binding site 2 [chemical binding]; other site 749927012113 putative substrate binding site 1 [chemical binding]; other site 749927012114 active site 749927012115 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 749927012116 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 749927012117 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 749927012118 active site 749927012119 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 749927012120 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927012121 active site 749927012122 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 749927012123 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 749927012124 putative ADP-binding pocket [chemical binding]; other site 749927012125 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927012126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927012127 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 749927012128 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 749927012129 TIGR00153 family protein; Region: TIGR00153 749927012130 Phosphate transporter family; Region: PHO4; pfam01384 749927012131 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 749927012132 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927012133 NAD binding site [chemical binding]; other site 749927012134 catalytic Zn binding site [ion binding]; other site 749927012135 structural Zn binding site [ion binding]; other site 749927012136 Predicted acyl esterases [General function prediction only]; Region: COG2936 749927012137 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 749927012138 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927012139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927012140 NAD(P) binding site [chemical binding]; other site 749927012141 active site 749927012142 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 749927012143 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927012144 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 749927012145 hydrophobic ligand binding site; other site 749927012146 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 749927012147 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927012148 active site 749927012149 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 749927012150 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 749927012151 active site 749927012152 DNA binding site [nucleotide binding] 749927012153 Int/Topo IB signature motif; other site 749927012154 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 749927012155 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 749927012156 FAD dependent oxidoreductase; Region: DAO; pfam01266 749927012157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927012158 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 749927012159 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 749927012160 [2Fe-2S] cluster binding site [ion binding]; other site 749927012161 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927012162 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 749927012163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927012164 S-adenosylmethionine binding site [chemical binding]; other site 749927012165 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 749927012166 Iron-containing redox enzyme; Region: Haem_oxygenas_2; pfam14518 749927012167 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 749927012168 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927012169 anti sigma factor interaction site; other site 749927012170 regulatory phosphorylation site [posttranslational modification]; other site 749927012171 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 749927012172 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 749927012173 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 749927012174 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927012175 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927012176 catalytic residue [active] 749927012177 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 749927012178 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 749927012179 amidohydrolase; Region: amidohydrolases; TIGR01891 749927012180 metal binding site [ion binding]; metal-binding site 749927012181 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 749927012182 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 749927012183 substrate binding pocket [chemical binding]; other site 749927012184 active site 749927012185 iron coordination sites [ion binding]; other site 749927012186 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 749927012187 active site 749927012188 non-prolyl cis peptide bond; other site 749927012189 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749927012190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927012191 dimer interface [polypeptide binding]; other site 749927012192 conserved gate region; other site 749927012193 putative PBP binding loops; other site 749927012194 ABC-ATPase subunit interface; other site 749927012195 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 749927012196 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 749927012197 Walker A/P-loop; other site 749927012198 ATP binding site [chemical binding]; other site 749927012199 Q-loop/lid; other site 749927012200 ABC transporter signature motif; other site 749927012201 Walker B; other site 749927012202 D-loop; other site 749927012203 H-loop/switch region; other site 749927012204 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749927012205 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927012206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927012207 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927012208 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927012209 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927012210 HTH domain; Region: HTH_11; pfam08279 749927012211 Predicted transcriptional regulator [Transcription]; Region: COG2378 749927012212 WYL domain; Region: WYL; pfam13280 749927012213 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927012214 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927012215 Winged helix DNA-binding domain; Region: HTH_42; cl19833 749927012216 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927012217 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927012218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927012219 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927012220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927012221 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 749927012222 nucleotide binding site/active site [active] 749927012223 HIT family signature motif; other site 749927012224 catalytic residue [active] 749927012225 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927012226 Uncharacterized conserved protein [Function unknown]; Region: COG3391 749927012227 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927012228 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927012229 Domain of unknown function (DUF4142); Region: DUF4142; cl17876 749927012230 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 749927012231 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 749927012232 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 749927012233 dinuclear metal binding motif [ion binding]; other site 749927012234 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 749927012235 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927012236 catalytic loop [active] 749927012237 iron binding site [ion binding]; other site 749927012238 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 749927012239 FAD binding pocket [chemical binding]; other site 749927012240 conserved FAD binding motif [chemical binding]; other site 749927012241 phosphate binding motif [ion binding]; other site 749927012242 beta-alpha-beta structure motif; other site 749927012243 NAD binding pocket [chemical binding]; other site 749927012244 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 749927012245 dinuclear metal binding motif [ion binding]; other site 749927012246 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 749927012247 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 749927012248 active site 749927012249 Domain of unknown function DUF59; Region: DUF59; pfam01883 749927012250 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 749927012251 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 749927012252 NAD binding site [chemical binding]; other site 749927012253 substrate binding site [chemical binding]; other site 749927012254 catalytic Zn binding site [ion binding]; other site 749927012255 structural Zn binding site [ion binding]; other site 749927012256 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 749927012257 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 749927012258 ring oligomerisation interface [polypeptide binding]; other site 749927012259 ATP/Mg binding site [chemical binding]; other site 749927012260 stacking interactions; other site 749927012261 hinge regions; other site 749927012262 TIR domain; Region: TIR_2; pfam13676 749927012263 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 749927012264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927012265 non-specific DNA binding site [nucleotide binding]; other site 749927012266 salt bridge; other site 749927012267 sequence-specific DNA binding site [nucleotide binding]; other site 749927012268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927012269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927012270 binding surface 749927012271 TPR motif; other site 749927012272 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927012273 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927012274 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927012275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927012276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927012277 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927012278 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927012279 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927012280 classical (c) SDRs; Region: SDR_c; cd05233 749927012281 NAD(P) binding site [chemical binding]; other site 749927012282 active site 749927012283 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 749927012284 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749927012285 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 749927012286 putative dimer interface [polypeptide binding]; other site 749927012287 N-terminal domain interface [polypeptide binding]; other site 749927012288 putative substrate binding pocket (H-site) [chemical binding]; other site 749927012289 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927012290 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927012291 putative DNA binding site [nucleotide binding]; other site 749927012292 putative Zn2+ binding site [ion binding]; other site 749927012293 Uncharacterized conserved protein [Function unknown]; Region: COG2353 749927012294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927012295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927012296 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 749927012297 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 749927012298 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 749927012299 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 749927012300 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 749927012301 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 749927012302 putative active site [active] 749927012303 putative catalytic site [active] 749927012304 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927012305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927012306 dimer interface [polypeptide binding]; other site 749927012307 conserved gate region; other site 749927012308 putative PBP binding loops; other site 749927012309 ABC-ATPase subunit interface; other site 749927012310 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927012311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927012312 putative PBP binding loops; other site 749927012313 dimer interface [polypeptide binding]; other site 749927012314 ABC-ATPase subunit interface; other site 749927012315 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927012316 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 749927012317 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927012318 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927012319 DNA binding site [nucleotide binding] 749927012320 domain linker motif; other site 749927012321 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927012322 dimerization interface [polypeptide binding]; other site 749927012323 ligand binding site [chemical binding]; other site 749927012324 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 749927012325 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 749927012326 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 749927012327 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 749927012328 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 749927012329 ligand binding site [chemical binding]; other site 749927012330 metal binding site [ion binding]; metal-binding site 749927012331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927012332 S-adenosylmethionine binding site [chemical binding]; other site 749927012333 Cytochrome P450; Region: p450; cl12078 749927012334 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927012335 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927012336 PAS domain S-box; Region: sensory_box; TIGR00229 749927012337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927012338 putative active site [active] 749927012339 heme pocket [chemical binding]; other site 749927012340 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927012341 metal binding site [ion binding]; metal-binding site 749927012342 active site 749927012343 I-site; other site 749927012344 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 749927012345 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 749927012346 putative FMN binding site [chemical binding]; other site 749927012347 putative dimer interface [polypeptide binding]; other site 749927012348 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 749927012349 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 749927012350 Cysteine-rich domain; Region: CCG; pfam02754 749927012351 Cysteine-rich domain; Region: CCG; pfam02754 749927012352 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 749927012353 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 749927012354 phosphopeptide binding site; other site 749927012355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927012356 metabolite-proton symporter; Region: 2A0106; TIGR00883 749927012357 putative substrate translocation pore; other site 749927012358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927012359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927012360 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 749927012361 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 749927012362 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 749927012363 shikimate binding site; other site 749927012364 NAD(P) binding site [chemical binding]; other site 749927012365 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927012366 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 749927012367 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 749927012368 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927012369 active site 749927012370 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927012371 active site 749927012372 metal binding site [ion binding]; metal-binding site 749927012373 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927012374 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927012375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927012376 dimer interface [polypeptide binding]; other site 749927012377 conserved gate region; other site 749927012378 putative PBP binding loops; other site 749927012379 ABC-ATPase subunit interface; other site 749927012380 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927012381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927012382 dimer interface [polypeptide binding]; other site 749927012383 conserved gate region; other site 749927012384 putative PBP binding loops; other site 749927012385 ABC-ATPase subunit interface; other site 749927012386 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 749927012387 AAA ATPase domain; Region: AAA_16; pfam13191 749927012388 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 749927012389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927012390 binding surface 749927012391 TPR motif; other site 749927012392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927012393 TPR motif; other site 749927012394 binding surface 749927012395 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 749927012396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927012397 binding surface 749927012398 TPR motif; other site 749927012399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927012400 binding surface 749927012401 TPR motif; other site 749927012402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927012403 binding surface 749927012404 TPR motif; other site 749927012405 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 749927012406 Uncharacterized alpha/beta hydrolase domain (DUF2235); Region: DUF2235; pfam09994 749927012407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927012408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927012409 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 749927012410 Coenzyme A binding pocket [chemical binding]; other site 749927012411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927012412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927012413 putative substrate translocation pore; other site 749927012414 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 749927012415 YcaO-like family; Region: YcaO; cl19253 749927012416 YjbR; Region: YjbR; cl15265 749927012417 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 749927012418 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 749927012419 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927012420 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927012421 DNA binding residues [nucleotide binding] 749927012422 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 749927012423 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 749927012424 Histidine kinase; Region: HisKA_3; pfam07730 749927012425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927012426 Mg2+ binding site [ion binding]; other site 749927012427 G-X-G motif; other site 749927012428 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927012429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927012430 active site 749927012431 phosphorylation site [posttranslational modification] 749927012432 intermolecular recognition site; other site 749927012433 dimerization interface [polypeptide binding]; other site 749927012434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927012435 DNA binding residues [nucleotide binding] 749927012436 dimerization interface [polypeptide binding]; other site 749927012437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927012438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927012439 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 749927012440 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927012441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927012442 Reductase C-terminal; Region: Reductase_C; pfam14759 749927012443 GTP cyclohydrolase I; Region: GTP_cyclohydroI; pfam01227 749927012444 active site 749927012445 Predicted transcriptional regulator [Transcription]; Region: COG2345 749927012446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927012447 putative DNA binding site [nucleotide binding]; other site 749927012448 putative Zn2+ binding site [ion binding]; other site 749927012449 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 749927012450 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927012451 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927012452 DNA binding site [nucleotide binding] 749927012453 domain linker motif; other site 749927012454 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 749927012455 ligand binding site [chemical binding]; other site 749927012456 dimerization interface (open form) [polypeptide binding]; other site 749927012457 dimerization interface (closed form) [polypeptide binding]; other site 749927012458 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 749927012459 Beta-galactosidase, domain 2; Region: BetaGal_dom2; cl19747 749927012460 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 749927012461 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 749927012462 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 749927012463 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 749927012464 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 749927012465 LysE type translocator; Region: LysE; cl00565 749927012466 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927012467 classical (c) SDRs; Region: SDR_c; cd05233 749927012468 NAD(P) binding site [chemical binding]; other site 749927012469 active site 749927012470 Cellulose binding domain; Region: CBM_2; pfam00553 749927012471 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 749927012472 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 749927012473 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 749927012474 putative catalytic site [active] 749927012475 putative metal binding site [ion binding]; other site 749927012476 putative phosphate binding site [ion binding]; other site 749927012477 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927012478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927012479 DNA binding site [nucleotide binding] 749927012480 domain linker motif; other site 749927012481 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 749927012482 ligand binding site [chemical binding]; other site 749927012483 dimerization interface (open form) [polypeptide binding]; other site 749927012484 dimerization interface (closed form) [polypeptide binding]; other site 749927012485 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 749927012486 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 749927012487 putative ligand binding site [chemical binding]; other site 749927012488 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 749927012489 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927012490 Walker A/P-loop; other site 749927012491 ATP binding site [chemical binding]; other site 749927012492 Q-loop/lid; other site 749927012493 ABC transporter signature motif; other site 749927012494 Walker B; other site 749927012495 D-loop; other site 749927012496 H-loop/switch region; other site 749927012497 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 749927012498 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927012499 TM-ABC transporter signature motif; other site 749927012500 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927012501 TM-ABC transporter signature motif; other site 749927012502 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927012503 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927012504 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927012505 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 749927012506 ribulokinase; Provisional; Region: PRK04123 749927012507 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 749927012508 N- and C-terminal domain interface [polypeptide binding]; other site 749927012509 active site 749927012510 MgATP binding site [chemical binding]; other site 749927012511 catalytic site [active] 749927012512 metal binding site [ion binding]; metal-binding site 749927012513 carbohydrate binding site [chemical binding]; other site 749927012514 homodimer interface [polypeptide binding]; other site 749927012515 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 749927012516 intersubunit interface [polypeptide binding]; other site 749927012517 active site 749927012518 Zn2+ binding site [ion binding]; other site 749927012519 L-arabinose isomerase; Provisional; Region: PRK02929 749927012520 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 749927012521 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 749927012522 trimer interface [polypeptide binding]; other site 749927012523 putative substrate binding site [chemical binding]; other site 749927012524 putative metal binding site [ion binding]; other site 749927012525 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 749927012526 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 749927012527 putative ligand binding site [chemical binding]; other site 749927012528 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 749927012529 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927012530 Walker A/P-loop; other site 749927012531 ATP binding site [chemical binding]; other site 749927012532 Q-loop/lid; other site 749927012533 ABC transporter signature motif; other site 749927012534 Walker B; other site 749927012535 D-loop; other site 749927012536 H-loop/switch region; other site 749927012537 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 749927012538 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927012539 TM-ABC transporter signature motif; other site 749927012540 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 749927012541 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 749927012542 ligand binding site [chemical binding]; other site 749927012543 dimerization interface (open form) [polypeptide binding]; other site 749927012544 dimerization interface (closed form) [polypeptide binding]; other site 749927012545 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 749927012546 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927012547 glycerol kinase; Provisional; Region: glpK; PRK00047 749927012548 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927012549 nucleotide binding site [chemical binding]; other site 749927012550 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 749927012551 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 749927012552 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927012553 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927012554 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 749927012555 amphipathic channel; other site 749927012556 Asn-Pro-Ala signature motifs; other site 749927012557 glycerol kinase; Provisional; Region: glpK; PRK00047 749927012558 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927012559 nucleotide binding site [chemical binding]; other site 749927012560 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 749927012561 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927012562 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 749927012563 Phosphotransferase enzyme family; Region: APH; pfam01636 749927012564 active site 749927012565 substrate binding site [chemical binding]; other site 749927012566 ATP binding site [chemical binding]; other site 749927012567 argininosuccinate synthase; Validated; Region: PRK05370 749927012568 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 749927012569 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927012570 putative NAD(P) binding site [chemical binding]; other site 749927012571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927012572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927012573 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927012574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927012575 Walker A motif; other site 749927012576 ATP binding site [chemical binding]; other site 749927012577 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927012578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927012579 binding surface 749927012580 TPR motif; other site 749927012581 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927012582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927012583 TPR motif; other site 749927012584 binding surface 749927012585 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927012586 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 749927012587 putative active site [active] 749927012588 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927012589 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 749927012590 AsnC family; Region: AsnC_trans_reg; pfam01037 749927012591 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927012592 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 749927012593 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927012594 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 749927012595 FAD binding domain; Region: FAD_binding_4; cl19922 749927012596 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 749927012597 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927012598 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927012599 DNA binding site [nucleotide binding] 749927012600 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927012601 ligand binding site [chemical binding]; other site 749927012602 dimerization interface [polypeptide binding]; other site 749927012603 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927012604 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927012605 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927012606 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927012607 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927012608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927012609 dimer interface [polypeptide binding]; other site 749927012610 conserved gate region; other site 749927012611 putative PBP binding loops; other site 749927012612 ABC-ATPase subunit interface; other site 749927012613 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927012614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927012615 dimer interface [polypeptide binding]; other site 749927012616 conserved gate region; other site 749927012617 putative PBP binding loops; other site 749927012618 ABC-ATPase subunit interface; other site 749927012619 Protein of unknown function, DUF624; Region: DUF624; cl02369 749927012620 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927012621 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 749927012622 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927012623 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927012624 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927012625 Methane oxygenase PmoA; Region: PmoA; pfam14100 749927012626 Amb_all domain; Region: Amb_all; smart00656 749927012627 Pectate lyase; Region: Pectate_lyase; pfam03211 749927012628 Pectinesterase; Region: Pectinesterase; cl01911 749927012629 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 749927012630 substrate binding site [chemical binding]; other site 749927012631 active site 749927012632 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 749927012633 Beta-galactosidase, domain 2; Region: BetaGal_dom2; cl19747 749927012634 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 749927012635 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 749927012636 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 749927012637 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927012638 anti sigma factor interaction site; other site 749927012639 regulatory phosphorylation site [posttranslational modification]; other site 749927012640 DNA binding site [nucleotide binding] 749927012641 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 749927012642 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927012643 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749927012644 Ligand Binding Site [chemical binding]; other site 749927012645 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749927012646 Ligand Binding Site [chemical binding]; other site 749927012647 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 749927012648 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 749927012649 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 749927012650 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 749927012651 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 749927012652 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 749927012653 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 749927012654 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 749927012655 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 749927012656 Walker A motif; other site 749927012657 ATP binding site [chemical binding]; other site 749927012658 Walker B motif; other site 749927012659 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 749927012660 Walker A motif; other site 749927012661 ATP binding site [chemical binding]; other site 749927012662 Walker B motif; other site 749927012663 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 749927012664 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 749927012665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927012666 TIGR01777 family protein; Region: yfcH 749927012667 NAD(P) binding site [chemical binding]; other site 749927012668 active site 749927012669 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927012670 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927012671 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927012672 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927012673 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 749927012674 NAD(P) binding site [chemical binding]; other site 749927012675 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 749927012676 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 749927012677 ligand binding site; other site 749927012678 oligomer interface; other site 749927012679 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 749927012680 dimer interface [polypeptide binding]; other site 749927012681 N-terminal domain interface [polypeptide binding]; other site 749927012682 sulfate 1 binding site; other site 749927012683 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 749927012684 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 749927012685 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 749927012686 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 749927012687 Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; cl02844 749927012688 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 749927012689 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927012690 anti sigma factor interaction site; other site 749927012691 regulatory phosphorylation site [posttranslational modification]; other site 749927012692 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927012693 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927012694 DNA binding residues [nucleotide binding] 749927012695 B12 binding domain; Region: B12-binding_2; pfam02607 749927012696 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 749927012697 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 749927012698 putative hydrophobic ligand binding site [chemical binding]; other site 749927012699 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927012700 sugar binding site [chemical binding]; other site 749927012701 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927012702 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927012703 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927012704 sugar binding site [chemical binding]; other site 749927012705 TROVE domain; Region: TROVE; pfam05731 749927012706 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 749927012707 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927012708 elongation factor G; Reviewed; Region: PRK13351 749927012709 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 749927012710 G1 box; other site 749927012711 putative GEF interaction site [polypeptide binding]; other site 749927012712 GTP/Mg2+ binding site [chemical binding]; other site 749927012713 Switch I region; other site 749927012714 G2 box; other site 749927012715 G3 box; other site 749927012716 Switch II region; other site 749927012717 G4 box; other site 749927012718 G5 box; other site 749927012719 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 749927012720 Elongation Factor G, domain II; Region: EFG_II; pfam14492 749927012721 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 749927012722 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 749927012723 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927012724 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927012725 catalytic residue [active] 749927012726 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 749927012727 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 749927012728 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 749927012729 hydrophobic ligand binding site; other site 749927012730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927012731 hypothetical protein; Provisional; Region: PRK06185 749927012732 Domain of unknown function (DUF385); Region: DUF385; cl04387 749927012733 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927012734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927012735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927012736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927012737 putative substrate translocation pore; other site 749927012738 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927012739 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927012740 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 749927012741 active site 749927012742 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927012743 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927012744 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 749927012745 acyl-CoA synthetase; Validated; Region: PRK05850 749927012746 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 749927012747 acyl-activating enzyme (AAE) consensus motif; other site 749927012748 active site 749927012749 Putative esterase; Region: Esterase; pfam00756 749927012750 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 749927012751 short chain dehydrogenase; Region: adh_short; pfam00106 749927012752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927012753 NAD(P) binding site [chemical binding]; other site 749927012754 active site 749927012755 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927012756 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927012757 active site 749927012758 TDP-binding site; other site 749927012759 acceptor substrate-binding pocket; other site 749927012760 homodimer interface [polypeptide binding]; other site 749927012761 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 749927012762 putative active site [active] 749927012763 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 749927012764 Protein of unknown function (DUF998); Region: DUF998; pfam06197 749927012765 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 749927012766 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 749927012767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 749927012768 short chain dehydrogenase; Provisional; Region: PRK05650 749927012769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927012770 NAD(P) binding site [chemical binding]; other site 749927012771 active site 749927012772 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927012773 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927012774 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927012775 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927012776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927012777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927012778 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927012779 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927012780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927012781 binding surface 749927012782 TPR motif; other site 749927012783 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927012784 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 749927012785 regulatory protein interface [polypeptide binding]; other site 749927012786 active site 749927012787 regulatory phosphorylation site [posttranslational modification]; other site 749927012788 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 749927012789 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 749927012790 active site 749927012791 P-loop; other site 749927012792 phosphorylation site [posttranslational modification] 749927012793 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 749927012794 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 749927012795 active site 749927012796 phosphorylation site [posttranslational modification] 749927012797 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 749927012798 putative substrate binding site [chemical binding]; other site 749927012799 putative ATP binding site [chemical binding]; other site 749927012800 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 749927012801 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 749927012802 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 749927012803 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 749927012804 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 749927012805 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 749927012806 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 749927012807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927012808 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 749927012809 ATP binding site [chemical binding]; other site 749927012810 Asp23 family; Region: Asp23; pfam03780 749927012811 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 749927012812 active site 749927012813 catalytic triad [active] 749927012814 oxyanion hole [active] 749927012815 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 749927012816 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 749927012817 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 749927012818 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 749927012819 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927012820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927012821 DNA binding site [nucleotide binding] 749927012822 domain linker motif; other site 749927012823 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 749927012824 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927012825 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927012826 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927012827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927012828 dimer interface [polypeptide binding]; other site 749927012829 conserved gate region; other site 749927012830 putative PBP binding loops; other site 749927012831 ABC-ATPase subunit interface; other site 749927012832 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927012833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927012834 dimer interface [polypeptide binding]; other site 749927012835 conserved gate region; other site 749927012836 putative PBP binding loops; other site 749927012837 ABC-ATPase subunit interface; other site 749927012838 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 749927012839 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927012840 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927012841 DNA binding site [nucleotide binding] 749927012842 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 749927012843 putative dimerization interface [polypeptide binding]; other site 749927012844 putative ligand binding site [chemical binding]; other site 749927012845 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 749927012846 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 749927012847 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 749927012848 NodB motif; other site 749927012849 active site 749927012850 catalytic site [active] 749927012851 metal binding site [ion binding]; metal-binding site 749927012852 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 749927012853 Di-iron ligands [ion binding]; other site 749927012854 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 749927012855 DNA-binding site [nucleotide binding]; DNA binding site 749927012856 RNA-binding motif; other site 749927012857 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 749927012858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927012859 S-adenosylmethionine binding site [chemical binding]; other site 749927012860 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927012861 FAD binding domain; Region: FAD_binding_4; pfam01565 749927012862 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 749927012863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 749927012864 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 749927012865 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 749927012866 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 749927012867 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 749927012868 oligomer interface [polypeptide binding]; other site 749927012869 metal binding site [ion binding]; metal-binding site 749927012870 metal binding site [ion binding]; metal-binding site 749927012871 putative Cl binding site [ion binding]; other site 749927012872 aspartate ring; other site 749927012873 basic sphincter; other site 749927012874 hydrophobic gate; other site 749927012875 periplasmic entrance; other site 749927012876 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 749927012877 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 749927012878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927012879 dimerization interface [polypeptide binding]; other site 749927012880 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927012881 dimerization interface [polypeptide binding]; other site 749927012882 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927012883 dimerization interface [polypeptide binding]; other site 749927012884 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 749927012885 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927012886 dimerization interface [polypeptide binding]; other site 749927012887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927012888 dimerization interface [polypeptide binding]; other site 749927012889 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927012890 dimerization interface [polypeptide binding]; other site 749927012891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927012892 dimerization interface [polypeptide binding]; other site 749927012893 GAF domain; Region: GAF_2; pfam13185 749927012894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927012895 Protein of unknown function (DUF4527); Region: DUF4527; pfam15030 749927012896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927012897 dimer interface [polypeptide binding]; other site 749927012898 phosphorylation site [posttranslational modification] 749927012899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927012900 ATP binding site [chemical binding]; other site 749927012901 Mg2+ binding site [ion binding]; other site 749927012902 G-X-G motif; other site 749927012903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927012904 active site 749927012905 phosphorylation site [posttranslational modification] 749927012906 intermolecular recognition site; other site 749927012907 dimerization interface [polypeptide binding]; other site 749927012908 ANTAR domain; Region: ANTAR; pfam03861 749927012909 GAF domain; Region: GAF_2; pfam13185 749927012910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927012911 PAS fold; Region: PAS_3; pfam08447 749927012912 putative active site [active] 749927012913 heme pocket [chemical binding]; other site 749927012914 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927012915 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 749927012916 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 749927012917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927012918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927012919 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 749927012920 putative dimerization interface [polypeptide binding]; other site 749927012921 pyruvate dehydrogenase; Provisional; Region: PRK06546 749927012922 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 749927012923 PYR/PP interface [polypeptide binding]; other site 749927012924 dimer interface [polypeptide binding]; other site 749927012925 tetramer interface [polypeptide binding]; other site 749927012926 TPP binding site [chemical binding]; other site 749927012927 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927012928 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 749927012929 TPP-binding site [chemical binding]; other site 749927012930 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 749927012931 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 749927012932 Fructosamine kinase; Region: Fructosamin_kin; cl17579 749927012933 Phosphotransferase enzyme family; Region: APH; pfam01636 749927012934 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 749927012935 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 749927012936 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 749927012937 Zn binding site [ion binding]; other site 749927012938 Protein of unknown function, DUF488; Region: DUF488; cl01246 749927012939 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927012940 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927012941 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927012942 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927012943 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927012944 DNA binding site [nucleotide binding] 749927012945 domain linker motif; other site 749927012946 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927012947 dimerization interface [polypeptide binding]; other site 749927012948 ligand binding site [chemical binding]; other site 749927012949 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 749927012950 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927012951 Walker A/P-loop; other site 749927012952 ATP binding site [chemical binding]; other site 749927012953 Q-loop/lid; other site 749927012954 ABC transporter signature motif; other site 749927012955 Walker B; other site 749927012956 D-loop; other site 749927012957 H-loop/switch region; other site 749927012958 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 749927012959 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927012960 TM-ABC transporter signature motif; other site 749927012961 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927012962 TM-ABC transporter signature motif; other site 749927012963 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 749927012964 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 749927012965 ligand binding site [chemical binding]; other site 749927012966 Domain of unknown function (DUF718); Region: DUF718; pfam05336 749927012967 L-rhamnose isomerase (RhaA); Region: RhaA; cl19165 749927012968 short chain dehydrogenase; Validated; Region: PRK08324 749927012969 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 749927012970 active site 749927012971 Zn2+ binding site [ion binding]; other site 749927012972 intersubunit interface [polypeptide binding]; other site 749927012973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927012974 NAD(P) binding site [chemical binding]; other site 749927012975 active site 749927012976 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 749927012977 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 749927012978 hexamer (dimer of trimers) interface [polypeptide binding]; other site 749927012979 substrate binding site [chemical binding]; other site 749927012980 trimer interface [polypeptide binding]; other site 749927012981 Mn binding site [ion binding]; other site 749927012982 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 749927012983 N- and C-terminal domain interface [polypeptide binding]; other site 749927012984 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 749927012985 active site 749927012986 putative catalytic site [active] 749927012987 metal binding site [ion binding]; metal-binding site 749927012988 ATP binding site [chemical binding]; other site 749927012989 carbohydrate binding site [chemical binding]; other site 749927012990 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927012991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927012992 active site 749927012993 phosphorylation site [posttranslational modification] 749927012994 intermolecular recognition site; other site 749927012995 dimerization interface [polypeptide binding]; other site 749927012996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927012997 DNA binding residues [nucleotide binding] 749927012998 dimerization interface [polypeptide binding]; other site 749927012999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927013000 Histidine kinase; Region: HisKA_3; pfam07730 749927013001 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927013002 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927013003 DNA binding site [nucleotide binding] 749927013004 domain linker motif; other site 749927013005 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 749927013006 putative dimerization interface [polypeptide binding]; other site 749927013007 putative ligand binding site [chemical binding]; other site 749927013008 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 749927013009 putative metal binding site [ion binding]; other site 749927013010 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 749927013011 putative metal binding site [ion binding]; other site 749927013012 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 749927013013 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 749927013014 active site 749927013015 catalytic site [active] 749927013016 Domain of unknown function (DUF305); Region: DUF305; cl17794 749927013017 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 749927013018 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927013019 sugar binding site [chemical binding]; other site 749927013020 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 749927013021 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 749927013022 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927013023 active site 749927013024 Helix-turn-helix domain; Region: HTH_18; pfam12833 749927013025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927013026 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 749927013027 DNA polymerase IV; Validated; Region: PRK03858 749927013028 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 749927013029 active site 749927013030 DNA binding site [nucleotide binding] 749927013031 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 749927013032 Lsr2; Region: Lsr2; pfam11774 749927013033 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 749927013034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927013035 putative substrate translocation pore; other site 749927013036 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 749927013037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927013038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927013039 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927013040 dimerization interface [polypeptide binding]; other site 749927013041 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 749927013042 CoA binding domain; Region: CoA_binding; pfam02629 749927013043 CoA-ligase; Region: Ligase_CoA; pfam00549 749927013044 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 749927013045 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 749927013046 CoA-ligase; Region: Ligase_CoA; pfam00549 749927013047 hypothetical protein; Provisional; Region: PRK05858 749927013048 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749927013049 PYR/PP interface [polypeptide binding]; other site 749927013050 dimer interface [polypeptide binding]; other site 749927013051 TPP binding site [chemical binding]; other site 749927013052 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927013053 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 749927013054 TPP-binding site; other site 749927013055 dimer interface [polypeptide binding]; other site 749927013056 formyl-coenzyme A transferase; Provisional; Region: PRK05398 749927013057 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 749927013058 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 749927013059 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 749927013060 CoA binding domain; Region: CoA_binding_2; pfam13380 749927013061 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 749927013062 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 749927013063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927013064 putative substrate translocation pore; other site 749927013065 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927013066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927013067 DNA-binding site [nucleotide binding]; DNA binding site 749927013068 FCD domain; Region: FCD; pfam07729 749927013069 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 749927013070 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 749927013071 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 749927013072 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 749927013073 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749927013074 molybdopterin cofactor binding site; other site 749927013075 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 749927013076 molybdopterin cofactor binding site; other site 749927013077 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 749927013078 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 749927013079 putative dimer interface [polypeptide binding]; other site 749927013080 [2Fe-2S] cluster binding site [ion binding]; other site 749927013081 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 749927013082 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 749927013083 SLBB domain; Region: SLBB; pfam10531 749927013084 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 749927013085 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927013086 catalytic loop [active] 749927013087 iron binding site [ion binding]; other site 749927013088 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 749927013089 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 749927013090 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 749927013091 Molybdopterin oxidoreductase Fe4S4 domain; Region: Molybdop_Fe4S4; pfam04879 749927013092 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 749927013093 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 749927013094 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 749927013095 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 749927013096 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 749927013097 glyoxylate carboligase; Provisional; Region: PRK11269 749927013098 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749927013099 PYR/PP interface [polypeptide binding]; other site 749927013100 dimer interface [polypeptide binding]; other site 749927013101 TPP binding site [chemical binding]; other site 749927013102 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927013103 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 749927013104 TPP-binding site [chemical binding]; other site 749927013105 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 749927013106 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 749927013107 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 749927013108 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 749927013109 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927013110 catalytic loop [active] 749927013111 iron binding site [ion binding]; other site 749927013112 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 749927013113 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 749927013114 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 749927013115 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 749927013116 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 749927013117 nucleoside/Zn binding site; other site 749927013118 dimer interface [polypeptide binding]; other site 749927013119 catalytic motif [active] 749927013120 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 749927013121 Sulfate transporter family; Region: Sulfate_transp; cl19250 749927013122 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 749927013123 putative active site pocket [active] 749927013124 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 749927013125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927013126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927013127 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 749927013128 Domain interface; other site 749927013129 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 749927013130 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 749927013131 ATP-NAD kinase; Region: NAD_kinase; cl01255 749927013132 SPFH domain / Band 7 family; Region: Band_7; pfam01145 749927013133 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 749927013134 nudix motif; other site 749927013135 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927013136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927013137 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927013138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927013139 putative DNA binding site [nucleotide binding]; other site 749927013140 putative Zn2+ binding site [ion binding]; other site 749927013141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 749927013142 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cd00569 749927013143 DNA-binding interface [nucleotide binding]; DNA binding site 749927013144 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 749927013145 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927013146 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927013147 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 749927013148 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927013149 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927013150 DNA binding site [nucleotide binding] 749927013151 domain linker motif; other site 749927013152 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927013153 dimerization interface [polypeptide binding]; other site 749927013154 ligand binding site [chemical binding]; other site 749927013155 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 749927013156 glutaminase; Provisional; Region: PRK00971 749927013157 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 749927013158 AAA domain; Region: AAA_12; pfam13087 749927013159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 749927013160 YheO-like PAS domain; Region: PAS_6; pfam08348 749927013161 HTH domain; Region: HTH_22; pfam13309 749927013162 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 749927013163 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 749927013164 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927013165 catalytic residue [active] 749927013166 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 749927013167 phosphate binding site [ion binding]; other site 749927013168 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 749927013169 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 749927013170 phosphate binding site [ion binding]; other site 749927013171 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927013172 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 749927013173 active site 749927013174 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 749927013175 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013176 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 749927013177 putative NADP binding site [chemical binding]; other site 749927013178 active site 749927013179 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927013180 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927013181 active site 749927013182 Acyl transferase domain; Region: Acyl_transf_1; cl08282 749927013183 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 749927013184 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 749927013185 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 749927013186 Phosphopantetheine attachment site; Region: PP-binding; cl09936 749927013187 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927013188 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927013189 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 749927013190 catalytic site [active] 749927013191 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927013192 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927013193 active site 749927013194 TDP-binding site; other site 749927013195 acceptor substrate-binding pocket; other site 749927013196 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 749927013197 classical (c) SDRs; Region: SDR_c; cd05233 749927013198 NAD(P) binding site [chemical binding]; other site 749927013199 active site 749927013200 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 749927013201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927013202 putative substrate translocation pore; other site 749927013203 histidinol-phosphatase; Provisional; Region: PRK07328 749927013204 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 749927013205 active site 749927013206 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 749927013207 nucleotide binding site [chemical binding]; other site 749927013208 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 749927013209 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927013210 dimer interface [polypeptide binding]; other site 749927013211 active site 749927013212 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927013213 dimerization interface [polypeptide binding]; other site 749927013214 putative DNA binding site [nucleotide binding]; other site 749927013215 putative Zn2+ binding site [ion binding]; other site 749927013216 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 749927013217 sugar binding site [chemical binding]; other site 749927013218 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 749927013219 CARDB; Region: CARDB; pfam07705 749927013220 CARDB; Region: CARDB; pfam07705 749927013221 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 749927013222 putative metal binding site [ion binding]; other site 749927013223 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 749927013224 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927013225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927013226 NAD(P) binding site [chemical binding]; other site 749927013227 active site 749927013228 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 749927013229 DoxX-like family; Region: DoxX_2; pfam13564 749927013230 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 749927013231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927013232 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 749927013233 dimerization interface [polypeptide binding]; other site 749927013234 substrate binding pocket [chemical binding]; other site 749927013235 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 749927013236 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 749927013237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927013238 motif II; other site 749927013239 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927013240 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927013241 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927013242 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927013243 DNA binding site [nucleotide binding] 749927013244 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927013245 ligand binding site [chemical binding]; other site 749927013246 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 749927013247 hypothetical protein; Provisional; Region: PRK07906 749927013248 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 749927013249 putative metal binding site [ion binding]; other site 749927013250 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927013251 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927013252 hypothetical protein; Provisional; Region: PRK08317 749927013253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927013254 S-adenosylmethionine binding site [chemical binding]; other site 749927013255 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 749927013256 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927013257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927013258 putative DNA binding site [nucleotide binding]; other site 749927013259 putative Zn2+ binding site [ion binding]; other site 749927013260 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 749927013261 putative hydrophobic ligand binding site [chemical binding]; other site 749927013262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927013263 active site 749927013264 catalytic tetrad [active] 749927013265 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927013266 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927013267 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 749927013268 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927013269 catalytic core [active] 749927013270 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 749927013271 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 749927013272 active site 749927013273 Zn binding site [ion binding]; other site 749927013274 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 749927013275 oligomer interface [polypeptide binding]; other site 749927013276 active site residues [active] 749927013277 malate dehydrogenase; Provisional; Region: PRK05442 749927013278 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 749927013279 NAD(P) binding site [chemical binding]; other site 749927013280 dimer interface [polypeptide binding]; other site 749927013281 malate binding site [chemical binding]; other site 749927013282 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927013283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927013284 putative DNA binding site [nucleotide binding]; other site 749927013285 putative Zn2+ binding site [ion binding]; other site 749927013286 Domain of unknown function (DUF4440); Region: DUF4440; pfam14534 749927013287 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927013288 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 749927013289 Predicted membrane protein [Function unknown]; Region: COG1289 749927013290 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 749927013291 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 749927013292 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 749927013293 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927013294 sugar binding site [chemical binding]; other site 749927013295 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 749927013296 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 749927013297 Tannase and feruloyl esterase; Region: Tannase; pfam07519 749927013298 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 749927013299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927013300 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 749927013301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927013302 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927013303 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927013304 NAD(P) binding site [chemical binding]; other site 749927013305 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 749927013306 hypothetical protein; Provisional; Region: PRK07906 749927013307 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 749927013308 putative metal binding site [ion binding]; other site 749927013309 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 749927013310 SxDxEG motif; other site 749927013311 active site 749927013312 metal binding site [ion binding]; metal-binding site 749927013313 homopentamer interface [polypeptide binding]; other site 749927013314 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 749927013315 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 749927013316 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 749927013317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927013318 dimer interface [polypeptide binding]; other site 749927013319 conserved gate region; other site 749927013320 putative PBP binding loops; other site 749927013321 ABC-ATPase subunit interface; other site 749927013322 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 749927013323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927013324 dimer interface [polypeptide binding]; other site 749927013325 conserved gate region; other site 749927013326 putative PBP binding loops; other site 749927013327 ABC-ATPase subunit interface; other site 749927013328 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 749927013329 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927013330 Walker A/P-loop; other site 749927013331 ATP binding site [chemical binding]; other site 749927013332 Q-loop/lid; other site 749927013333 ABC transporter signature motif; other site 749927013334 Walker B; other site 749927013335 D-loop; other site 749927013336 H-loop/switch region; other site 749927013337 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927013338 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927013339 Walker A/P-loop; other site 749927013340 ATP binding site [chemical binding]; other site 749927013341 Q-loop/lid; other site 749927013342 ABC transporter signature motif; other site 749927013343 Walker B; other site 749927013344 D-loop; other site 749927013345 H-loop/switch region; other site 749927013346 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927013347 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 749927013348 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927013349 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 749927013350 dimer interface [polypeptide binding]; other site 749927013351 catalytic triad [active] 749927013352 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 749927013353 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 749927013354 conserved hypothetical protein; Region: TIGR03847 749927013355 conserved hypothetical protein; Region: TIGR03843 749927013356 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 749927013357 Phosphotransferase enzyme family; Region: APH; pfam01636 749927013358 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 749927013359 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 749927013360 prohibitin homologues; Region: PHB; smart00244 749927013361 SPFH domain / Band 7 family; Region: Band_7; pfam01145 749927013362 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 749927013363 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 749927013364 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927013365 active site 749927013366 SCP_GAPR-1_like: SCP-like extracellular protein domain, golgi-associated plant pathogenesis related protein (GAPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian...; Region: SCP_GAPR-1_like; cd05382 749927013367 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 749927013368 Mechanosensitive ion channel; Region: MS_channel; pfam00924 749927013369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927013370 metabolite-proton symporter; Region: 2A0106; TIGR00883 749927013371 putative substrate translocation pore; other site 749927013372 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927013373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927013374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927013375 dimerization interface [polypeptide binding]; other site 749927013376 hypothetical protein; Provisional; Region: PRK08244 749927013377 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927013378 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927013379 active site 749927013380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927013381 dimerization interface [polypeptide binding]; other site 749927013382 putative DNA binding site [nucleotide binding]; other site 749927013383 putative Zn2+ binding site [ion binding]; other site 749927013384 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 749927013385 putative hydrophobic ligand binding site [chemical binding]; other site 749927013386 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927013387 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927013388 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 749927013389 active site 749927013390 catalytic triad [active] 749927013391 oxyanion hole [active] 749927013392 RibD C-terminal domain; Region: RibD_C; cl17279 749927013393 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 749927013394 CGNR zinc finger; Region: zf-CGNR; pfam11706 749927013395 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749927013396 active site 749927013397 DNA binding site [nucleotide binding] 749927013398 Int/Topo IB signature motif; other site 749927013399 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927013400 YCII-related domain; Region: YCII; cl00999 749927013401 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927013402 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927013403 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927013404 dimerization interface [polypeptide binding]; other site 749927013405 putative DNA binding site [nucleotide binding]; other site 749927013406 putative Zn2+ binding site [ion binding]; other site 749927013407 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 749927013408 putative hydrophobic ligand binding site [chemical binding]; other site 749927013409 Protein of unknown function (DUF505); Region: DUF505; cl19549 749927013410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927013411 Cupin; Region: Cupin_6; pfam12852 749927013412 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 749927013413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927013414 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927013415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927013416 NAD(P) binding site [chemical binding]; other site 749927013417 active site 749927013418 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 749927013419 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 749927013420 YCII-related domain; Region: YCII; cl00999 749927013421 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927013422 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927013423 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927013424 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927013425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927013426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927013427 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927013428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927013429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927013430 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927013431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927013432 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 749927013433 Walker A/P-loop; other site 749927013434 ATP binding site [chemical binding]; other site 749927013435 Q-loop/lid; other site 749927013436 ABC transporter signature motif; other site 749927013437 Walker B; other site 749927013438 D-loop; other site 749927013439 H-loop/switch region; other site 749927013440 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927013441 ABC-2 type transporter; Region: ABC2_membrane; cl17235 749927013442 SNF2 Helicase protein; Region: DUF3670; pfam12419 749927013443 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 749927013444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927013445 ATP binding site [chemical binding]; other site 749927013446 putative Mg++ binding site [ion binding]; other site 749927013447 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 749927013448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927013449 nucleotide binding region [chemical binding]; other site 749927013450 ATP-binding site [chemical binding]; other site 749927013451 SWIM zinc finger; Region: SWIM; cl19527 749927013452 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927013453 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927013454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927013455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927013456 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927013457 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 749927013458 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927013459 active site 749927013460 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 749927013461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927013462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927013463 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749927013464 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927013465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927013466 salt bridge; other site 749927013467 non-specific DNA binding site [nucleotide binding]; other site 749927013468 sequence-specific DNA binding site [nucleotide binding]; other site 749927013469 Cupin domain; Region: Cupin_2; cl17218 749927013470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927013471 Coenzyme A binding pocket [chemical binding]; other site 749927013472 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927013473 hydrophobic ligand binding site; other site 749927013474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927013475 dimerization interface [polypeptide binding]; other site 749927013476 putative DNA binding site [nucleotide binding]; other site 749927013477 putative Zn2+ binding site [ion binding]; other site 749927013478 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 749927013479 putative hydrophobic ligand binding site [chemical binding]; other site 749927013480 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749927013481 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 749927013482 active site 749927013483 DNA binding site [nucleotide binding] 749927013484 Int/Topo IB signature motif; other site 749927013485 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 749927013486 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 749927013487 putative active site [active] 749927013488 catalytic site [active] 749927013489 putative metal binding site [ion binding]; other site 749927013490 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 749927013491 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927013492 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 749927013493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927013494 putative substrate translocation pore; other site 749927013495 thymidine kinase; Provisional; Region: PRK04296 749927013496 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 749927013497 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 749927013498 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 749927013499 dimer interface [polypeptide binding]; other site 749927013500 ADP-ribose binding site [chemical binding]; other site 749927013501 active site 749927013502 nudix motif; other site 749927013503 metal binding site [ion binding]; metal-binding site 749927013504 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 749927013505 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 749927013506 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 749927013507 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 749927013508 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 749927013509 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 749927013510 Ligand binding site; other site 749927013511 Putative Catalytic site; other site 749927013512 DXD motif; other site 749927013513 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 749927013514 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 749927013515 putative active site [active] 749927013516 catalytic triad [active] 749927013517 putative dimer interface [polypeptide binding]; other site 749927013518 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 749927013519 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 749927013520 active site 749927013521 KamA family protein; Region: TIGR00238; cl15377 749927013522 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 749927013523 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 749927013524 conserved cys residue [active] 749927013525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 749927013526 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927013527 dimerization interface [polypeptide binding]; other site 749927013528 putative DNA binding site [nucleotide binding]; other site 749927013529 putative Zn2+ binding site [ion binding]; other site 749927013530 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927013531 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927013532 DNA binding site [nucleotide binding] 749927013533 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927013534 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927013535 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927013536 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927013537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927013538 TPR motif; other site 749927013539 binding surface 749927013540 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927013541 Homeodomain-like domain; Region: HTH_23; pfam13384 749927013542 Winged helix-turn helix; Region: HTH_29; pfam13551 749927013543 Homeodomain-like domain; Region: HTH_32; pfam13565 749927013544 DDE superfamily endonuclease; Region: DDE_3; cl19249 749927013545 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 749927013546 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 749927013547 active site 749927013548 zinc binding site [ion binding]; other site 749927013549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927013550 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927013551 DNA binding site [nucleotide binding] 749927013552 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927013553 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 749927013554 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 749927013555 active site 749927013556 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 749927013557 B12 binding site [chemical binding]; other site 749927013558 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 749927013559 substrate binding site [chemical binding]; other site 749927013560 B12 cofactor binding site [chemical binding]; other site 749927013561 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 749927013562 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 749927013563 asparagine synthetase A; Reviewed; Region: PRK06462 749927013564 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 749927013565 motif 1; other site 749927013566 dimer interface [polypeptide binding]; other site 749927013567 active site 749927013568 motif 2; other site 749927013569 motif 3; other site 749927013570 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 749927013571 phosphate binding site [ion binding]; other site 749927013572 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 749927013573 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927013574 acyl-activating enzyme (AAE) consensus motif; other site 749927013575 AMP binding site [chemical binding]; other site 749927013576 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927013577 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 749927013578 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 749927013579 homodimer interface [polypeptide binding]; other site 749927013580 substrate-cofactor binding pocket; other site 749927013581 catalytic residue [active] 749927013582 FkbH-like domain; Region: FkbH; TIGR01686 749927013583 Acid Phosphatase; Region: Acid_PPase; cl17256 749927013584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927013585 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 749927013586 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 749927013587 active site 749927013588 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927013589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927013590 non-specific DNA binding site [nucleotide binding]; other site 749927013591 salt bridge; other site 749927013592 sequence-specific DNA binding site [nucleotide binding]; other site 749927013593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927013594 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 749927013595 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927013596 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 749927013597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927013598 catalytic residue [active] 749927013599 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 749927013600 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 749927013601 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 749927013602 active sites [active] 749927013603 tetramer interface [polypeptide binding]; other site 749927013604 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 749927013605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927013606 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 749927013607 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927013608 acyl carrier protein; Provisional; Region: PRK07081 749927013609 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 749927013610 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927013611 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927013612 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 749927013613 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 749927013614 Condensation domain; Region: Condensation; pfam00668 749927013615 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927013616 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927013617 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927013618 acyl-activating enzyme (AAE) consensus motif; other site 749927013619 AMP binding site [chemical binding]; other site 749927013620 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013621 Condensation domain; Region: Condensation; cl19241 749927013622 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927013623 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 749927013624 Condensation domain; Region: Condensation; pfam00668 749927013625 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927013626 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927013627 acyl-activating enzyme (AAE) consensus motif; other site 749927013628 AMP binding site [chemical binding]; other site 749927013629 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013630 Condensation domain; Region: Condensation; cl19241 749927013631 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927013632 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927013633 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927013634 acyl-activating enzyme (AAE) consensus motif; other site 749927013635 AMP binding site [chemical binding]; other site 749927013636 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013637 Condensation domain; Region: Condensation; cl19241 749927013638 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013639 Condensation domain; Region: Condensation; cl19241 749927013640 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 749927013641 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927013642 MbtH-like protein; Region: MbtH; cl01279 749927013643 Condensation domain; Region: Condensation; cl19241 749927013644 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927013645 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013646 Condensation domain; Region: Condensation; cl19241 749927013647 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927013648 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927013649 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927013650 acyl-activating enzyme (AAE) consensus motif; other site 749927013651 AMP binding site [chemical binding]; other site 749927013652 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013653 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927013654 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927013655 acyl-activating enzyme (AAE) consensus motif; other site 749927013656 AMP binding site [chemical binding]; other site 749927013657 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013658 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 749927013659 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 749927013660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927013661 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927013662 putative substrate translocation pore; other site 749927013663 allantoate amidohydrolase; Reviewed; Region: PRK09290 749927013664 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 749927013665 active site 749927013666 metal binding site [ion binding]; metal-binding site 749927013667 dimer interface [polypeptide binding]; other site 749927013668 Helix-turn-helix domain; Region: HTH_20; pfam12840 749927013669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927013670 S-adenosylmethionine binding site [chemical binding]; other site 749927013671 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 749927013672 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927013673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927013674 homodimer interface [polypeptide binding]; other site 749927013675 catalytic residue [active] 749927013676 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927013677 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927013678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927013679 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927013680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927013681 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 749927013682 putative substrate binding pocket [chemical binding]; other site 749927013683 putative dimerization interface [polypeptide binding]; other site 749927013684 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 749927013685 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927013686 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 749927013687 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927013688 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 749927013689 SnoaL-like domain; Region: SnoaL_4; pfam13577 749927013690 NIPSNAP; Region: NIPSNAP; pfam07978 749927013691 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl19826 749927013692 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 749927013693 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 749927013694 active site pocket [active] 749927013695 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927013696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927013697 DNA-binding site [nucleotide binding]; DNA binding site 749927013698 FCD domain; Region: FCD; pfam07729 749927013699 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927013700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927013701 dimer interface [polypeptide binding]; other site 749927013702 conserved gate region; other site 749927013703 putative PBP binding loops; other site 749927013704 ABC-ATPase subunit interface; other site 749927013705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927013706 dimer interface [polypeptide binding]; other site 749927013707 conserved gate region; other site 749927013708 putative PBP binding loops; other site 749927013709 ABC-ATPase subunit interface; other site 749927013710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 749927013711 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 749927013712 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927013713 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927013714 MbtH-like protein; Region: MbtH; cl01279 749927013715 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927013716 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927013717 acyl-activating enzyme (AAE) consensus motif; other site 749927013718 AMP binding site [chemical binding]; other site 749927013719 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013720 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 749927013721 dimer interface [polypeptide binding]; other site 749927013722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927013723 catalytic residue [active] 749927013724 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 749927013725 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 749927013726 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 749927013727 B12 binding site [chemical binding]; other site 749927013728 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 749927013729 substrate binding site [chemical binding]; other site 749927013730 B12 cofactor binding site [chemical binding]; other site 749927013731 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 749927013732 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 749927013733 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 749927013734 Condensation domain; Region: Condensation; pfam00668 749927013735 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927013736 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927013737 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927013738 acyl-activating enzyme (AAE) consensus motif; other site 749927013739 AMP binding site [chemical binding]; other site 749927013740 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013741 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 749927013742 Condensation domain; Region: Condensation; pfam00668 749927013743 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927013744 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927013745 acyl-activating enzyme (AAE) consensus motif; other site 749927013746 AMP binding site [chemical binding]; other site 749927013747 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013748 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 749927013749 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 749927013750 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 749927013751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927013752 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927013753 putative substrate translocation pore; other site 749927013754 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 749927013755 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927013756 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927013757 acyl-activating enzyme (AAE) consensus motif; other site 749927013758 AMP binding site [chemical binding]; other site 749927013759 Condensation domain; Region: Condensation; pfam00668 749927013760 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927013761 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927013762 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927013763 acyl-activating enzyme (AAE) consensus motif; other site 749927013764 AMP binding site [chemical binding]; other site 749927013765 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927013766 Condensation domain; Region: Condensation; cl19241 749927013767 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 749927013768 Condensation domain; Region: Condensation; pfam00668 749927013769 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927013770 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927013771 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927013772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927013773 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927013774 DNA binding site [nucleotide binding] 749927013775 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927013776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927013777 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 749927013778 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927013779 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927013780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927013781 TPR motif; other site 749927013782 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927013783 binding surface 749927013784 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927013785 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927013786 DNA binding residues [nucleotide binding] 749927013787 HEAT repeats; Region: HEAT_2; pfam13646 749927013788 HEAT repeats; Region: HEAT_2; pfam13646 749927013789 Leishmanolysin; Region: Peptidase_M8; cl19482 749927013790 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749927013791 Switch II region; other site 749927013792 G4 box; other site 749927013793 G5 box; other site 749927013794 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 749927013795 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 749927013796 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 749927013797 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 749927013798 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 749927013799 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 749927013800 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927013801 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927013802 putative sugar binding sites [chemical binding]; other site 749927013803 Q-X-W motif; other site 749927013804 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 749927013805 active site 749927013806 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927013807 Cytochrome P450; Region: p450; pfam00067 749927013808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927013809 S-adenosylmethionine binding site [chemical binding]; other site 749927013810 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927013811 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927013812 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927013813 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 749927013814 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 749927013815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927013816 Histidine kinase; Region: HisKA_3; pfam07730 749927013817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927013818 ATP binding site [chemical binding]; other site 749927013819 Mg2+ binding site [ion binding]; other site 749927013820 G-X-G motif; other site 749927013821 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927013822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927013823 active site 749927013824 phosphorylation site [posttranslational modification] 749927013825 intermolecular recognition site; other site 749927013826 dimerization interface [polypeptide binding]; other site 749927013827 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927013828 DNA binding residues [nucleotide binding] 749927013829 dimerization interface [polypeptide binding]; other site 749927013830 response regulator; Provisional; Region: PRK09483 749927013831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927013832 DNA binding residues [nucleotide binding] 749927013833 dimerization interface [polypeptide binding]; other site 749927013834 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 749927013835 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 749927013836 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 749927013837 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 749927013838 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 749927013839 metal ion-dependent adhesion site (MIDAS); other site 749927013840 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 749927013841 phage tail protein domain; Region: tail_TIGR02242 749927013842 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 749927013843 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 749927013844 PAAR motif; Region: PAAR_motif; pfam05488 749927013845 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 749927013846 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 749927013847 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 749927013848 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 749927013849 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 749927013850 large tegument protein UL36; Provisional; Region: PHA03247 749927013851 large tegument protein UL36; Provisional; Region: PHA03247 749927013852 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 749927013853 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 749927013854 Phage-related protein [Function unknown]; Region: COG5412 749927013855 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 749927013856 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 749927013857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927013858 Walker A motif; other site 749927013859 ATP binding site [chemical binding]; other site 749927013860 Walker B motif; other site 749927013861 arginine finger; other site 749927013862 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 749927013863 Right handed beta helix region; Region: Beta_helix; pfam13229 749927013864 hypothetical protein; Provisional; Region: PRK08204 749927013865 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927013866 active site 749927013867 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 749927013868 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 749927013869 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927013870 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927013871 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 749927013872 active site 749927013873 citrylCoA binding site [chemical binding]; other site 749927013874 oxalacetate binding site [chemical binding]; other site 749927013875 coenzyme A binding site [chemical binding]; other site 749927013876 catalytic triad [active] 749927013877 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 749927013878 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 749927013879 active site 749927013880 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927013881 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927013882 NAD(P) binding site [chemical binding]; other site 749927013883 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927013884 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927013885 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 749927013886 active site 749927013887 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 749927013888 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 749927013889 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 749927013890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927013891 Walker A/P-loop; other site 749927013892 ATP binding site [chemical binding]; other site 749927013893 Q-loop/lid; other site 749927013894 ABC transporter signature motif; other site 749927013895 Walker B; other site 749927013896 D-loop; other site 749927013897 H-loop/switch region; other site 749927013898 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 749927013899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927013900 Walker A/P-loop; other site 749927013901 ATP binding site [chemical binding]; other site 749927013902 Q-loop/lid; other site 749927013903 ABC transporter signature motif; other site 749927013904 Walker B; other site 749927013905 D-loop; other site 749927013906 H-loop/switch region; other site 749927013907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927013908 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927013909 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 749927013910 short chain dehydrogenase; Provisional; Region: PRK06180 749927013911 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 749927013912 NADP binding site [chemical binding]; other site 749927013913 active site 749927013914 steroid binding site; other site 749927013915 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 749927013916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927013917 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 749927013918 dimerization interface [polypeptide binding]; other site 749927013919 substrate binding pocket [chemical binding]; other site 749927013920 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 749927013921 active site residue [active] 749927013922 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 749927013923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927013924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927013925 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749927013926 active site 749927013927 catalytic triad [active] 749927013928 oxyanion hole [active] 749927013929 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927013930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927013931 putative DNA binding site [nucleotide binding]; other site 749927013932 putative Zn2+ binding site [ion binding]; other site 749927013933 AsnC family; Region: AsnC_trans_reg; pfam01037 749927013934 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 749927013935 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 749927013936 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 749927013937 active site 749927013938 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 749927013939 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 749927013940 active site 749927013941 metal binding site 1 [ion binding]; metal-binding site 749927013942 putative 5' ssDNA interaction site; other site 749927013943 metal binding site 3; metal-binding site 749927013944 metal binding site 2 [ion binding]; metal-binding site 749927013945 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 749927013946 DNA binding site [nucleotide binding] 749927013947 metal binding site [ion binding]; metal-binding site 749927013948 hypothetical protein; Provisional; Region: PRK01346 749927013949 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 749927013950 Sterol carrier protein domain; Region: SCP2_2; pfam13530 749927013951 hypothetical protein; Provisional; Region: PRK01346 749927013952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 749927013953 Sterol carrier protein domain; Region: SCP2_2; pfam13530 749927013954 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 749927013955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927013956 ATP binding site [chemical binding]; other site 749927013957 putative Mg++ binding site [ion binding]; other site 749927013958 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927013959 nucleotide binding region [chemical binding]; other site 749927013960 ATP-binding site [chemical binding]; other site 749927013961 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 749927013962 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 749927013963 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 749927013964 diacylglycerol kinase; Reviewed; Region: PRK11914 749927013965 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 749927013966 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 749927013967 Predicted transcriptional regulator [Transcription]; Region: COG2378 749927013968 WYL domain; Region: WYL; pfam13280 749927013969 Predicted transcriptional regulator [Transcription]; Region: COG2378 749927013970 WYL domain; Region: WYL; pfam13280 749927013971 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927013972 dimerization interface [polypeptide binding]; other site 749927013973 putative DNA binding site [nucleotide binding]; other site 749927013974 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927013975 putative Zn2+ binding site [ion binding]; other site 749927013976 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927013977 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927013978 putative NAD(P) binding site [chemical binding]; other site 749927013979 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 749927013980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927013981 NAD(P) binding site [chemical binding]; other site 749927013982 active site 749927013983 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 749927013984 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 749927013985 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 749927013986 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 749927013987 active site 749927013988 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 749927013989 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 749927013990 Putative esterase; Region: Esterase; pfam00756 749927013991 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 749927013992 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 749927013993 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 749927013994 active site 749927013995 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 749927013996 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 749927013997 active site 749927013998 Pup-like protein; Region: Pup; cl05289 749927013999 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 749927014000 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 749927014001 nudix motif; other site 749927014002 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927014003 active site 749927014004 catalytic tetrad [active] 749927014005 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927014006 dimerization interface [polypeptide binding]; other site 749927014007 putative DNA binding site [nucleotide binding]; other site 749927014008 putative Zn2+ binding site [ion binding]; other site 749927014009 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927014010 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 749927014011 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 749927014012 EamA-like transporter family; Region: EamA; pfam00892 749927014013 EamA-like transporter family; Region: EamA; pfam00892 749927014014 proteasome ATPase; Region: pup_AAA; TIGR03689 749927014015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927014016 Walker A motif; other site 749927014017 ATP binding site [chemical binding]; other site 749927014018 Walker B motif; other site 749927014019 arginine finger; other site 749927014020 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 749927014021 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 749927014022 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 749927014023 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 749927014024 tRNA methyltransferase complex GCD14 subunit N-term; Region: GCD14_N; pfam14801 749927014025 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 749927014026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927014027 S-adenosylmethionine binding site [chemical binding]; other site 749927014028 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 749927014029 Peptidase family M50; Region: Peptidase_M50; pfam02163 749927014030 active site 749927014031 putative substrate binding region [chemical binding]; other site 749927014032 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 749927014033 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 749927014034 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 749927014035 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 749927014036 active site 2 [active] 749927014037 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 749927014038 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 749927014039 P-loop; other site 749927014040 Magnesium ion binding site [ion binding]; other site 749927014041 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 749927014042 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 749927014043 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 749927014044 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 749927014045 homodimer interface [polypeptide binding]; other site 749927014046 putative metal binding site [ion binding]; other site 749927014047 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 749927014048 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 749927014049 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 749927014050 DNA binding site [nucleotide binding] 749927014051 active site 749927014052 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 749927014053 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 749927014054 AlkA N-terminal domain; Region: AlkA_N; pfam06029 749927014055 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 749927014056 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 749927014057 minor groove reading motif; other site 749927014058 helix-hairpin-helix signature motif; other site 749927014059 substrate binding pocket [chemical binding]; other site 749927014060 active site 749927014061 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 749927014062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927014063 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 749927014064 active site 749927014065 motif I; other site 749927014066 motif II; other site 749927014067 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 749927014068 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 749927014069 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 749927014070 substrate binding pocket [chemical binding]; other site 749927014071 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 749927014072 B12 binding site [chemical binding]; other site 749927014073 cobalt ligand [ion binding]; other site 749927014074 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 749927014075 PAC2 family; Region: PAC2; pfam09754 749927014076 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927014077 active site 749927014078 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 749927014079 CGNR zinc finger; Region: zf-CGNR; pfam11706 749927014080 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 749927014081 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927014082 active site 749927014083 metal binding site [ion binding]; metal-binding site 749927014084 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927014085 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 749927014086 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 749927014087 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927014088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927014089 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927014090 putative substrate translocation pore; other site 749927014091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927014092 dimerization interface [polypeptide binding]; other site 749927014093 putative DNA binding site [nucleotide binding]; other site 749927014094 putative Zn2+ binding site [ion binding]; other site 749927014095 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927014096 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927014097 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 749927014098 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749927014099 ABC transporter; Region: ABC_tran_2; pfam12848 749927014100 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749927014101 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 749927014102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 749927014103 active site 749927014104 nucleotide binding site [chemical binding]; other site 749927014105 HIGH motif; other site 749927014106 KMSKS motif; other site 749927014107 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 749927014108 putative tRNA binding surface [nucleotide binding]; other site 749927014109 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927014110 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 749927014111 DNA binding residues [nucleotide binding] 749927014112 dimer interface [polypeptide binding]; other site 749927014113 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 749927014114 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 749927014115 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927014116 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927014117 active site 749927014118 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 749927014119 Protein of unknown function, DUF484; Region: DUF484; cl17449 749927014120 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 749927014121 metal ion-dependent adhesion site (MIDAS); other site 749927014122 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 749927014123 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 749927014124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927014125 Walker B motif; other site 749927014126 arginine finger; other site 749927014127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927014128 ferrochelatase; Reviewed; Region: hemH; PRK00035 749927014129 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 749927014130 C-terminal domain interface [polypeptide binding]; other site 749927014131 active site 749927014132 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 749927014133 active site 749927014134 N-terminal domain interface [polypeptide binding]; other site 749927014135 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927014136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927014137 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927014138 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 749927014139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927014140 putative substrate translocation pore; other site 749927014141 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 749927014142 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 749927014143 NAD binding site [chemical binding]; other site 749927014144 homotetramer interface [polypeptide binding]; other site 749927014145 homodimer interface [polypeptide binding]; other site 749927014146 substrate binding site [chemical binding]; other site 749927014147 active site 749927014148 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 749927014149 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 749927014150 NAD(P) binding site [chemical binding]; other site 749927014151 homotetramer interface [polypeptide binding]; other site 749927014152 homodimer interface [polypeptide binding]; other site 749927014153 active site 749927014154 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 749927014155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927014156 putative substrate translocation pore; other site 749927014157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927014158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927014159 active site 749927014160 dimerization interface [polypeptide binding]; other site 749927014161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927014162 DNA binding site [nucleotide binding] 749927014163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927014164 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927014165 dimerization interface [polypeptide binding]; other site 749927014166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927014167 dimer interface [polypeptide binding]; other site 749927014168 phosphorylation site [posttranslational modification] 749927014169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927014170 ATP binding site [chemical binding]; other site 749927014171 Mg2+ binding site [ion binding]; other site 749927014172 G-X-G motif; other site 749927014173 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 749927014174 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 749927014175 active site 749927014176 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 749927014177 hypothetical protein; Provisional; Region: PRK13685 749927014178 von Willebrand factor type A domain; Region: VWA_2; pfam13519 749927014179 metal ion-dependent adhesion site (MIDAS); other site 749927014180 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 749927014181 Protein of unknown function DUF58; Region: DUF58; pfam01882 749927014182 MoxR-like ATPases [General function prediction only]; Region: COG0714 749927014183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927014184 Walker A motif; other site 749927014185 ATP binding site [chemical binding]; other site 749927014186 Walker B motif; other site 749927014187 arginine finger; other site 749927014188 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 749927014189 GTP binding site; other site 749927014190 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 749927014191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927014192 S-adenosylmethionine binding site [chemical binding]; other site 749927014193 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 749927014194 NlpC/P60 family; Region: NLPC_P60; pfam00877 749927014195 aconitate hydratase; Validated; Region: PRK09277 749927014196 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 749927014197 substrate binding site [chemical binding]; other site 749927014198 ligand binding site [chemical binding]; other site 749927014199 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 749927014200 substrate binding site [chemical binding]; other site 749927014201 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 749927014202 MgtC family; Region: MgtC; pfam02308 749927014203 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927014204 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927014205 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927014206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927014207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927014208 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927014209 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 749927014210 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 749927014211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927014212 Histidine-specific methyltransferase, SAM-dependent; Region: Methyltransf_33; pfam10017 749927014213 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 749927014214 putative active site [active] 749927014215 putative dimer interface [polypeptide binding]; other site 749927014216 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 749927014217 DinB superfamily; Region: DinB_2; pfam12867 749927014218 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; pfam03781 749927014219 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 749927014220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927014221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927014222 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 749927014223 putative dimerization interface [polypeptide binding]; other site 749927014224 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 749927014225 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 749927014226 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 749927014227 NAD(P) binding pocket [chemical binding]; other site 749927014228 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927014229 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 749927014230 EspG family; Region: ESX-1_EspG; pfam14011 749927014231 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 749927014232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927014233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927014234 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 749927014235 Domain of unknown function DUF21; Region: DUF21; pfam01595 749927014236 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 749927014237 Transporter associated domain; Region: CorC_HlyC; pfam03471 749927014238 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 749927014239 Domain of unknown function DUF21; Region: DUF21; pfam01595 749927014240 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 749927014241 large tegument protein UL36; Provisional; Region: PHA03247 749927014242 transcription termination factor Rho; Provisional; Region: PRK12678 749927014243 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927014244 active site 749927014245 catalytic tetrad [active] 749927014246 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927014247 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927014248 non-specific DNA binding site [nucleotide binding]; other site 749927014249 salt bridge; other site 749927014250 sequence-specific DNA binding site [nucleotide binding]; other site 749927014251 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927014252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927014253 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927014254 NAD(P) binding site [chemical binding]; other site 749927014255 active site 749927014256 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 749927014257 Ligand binding site; other site 749927014258 DXD motif; other site 749927014259 Putative Catalytic site; other site 749927014260 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927014261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927014262 NAD(P) binding site [chemical binding]; other site 749927014263 active site 749927014264 glycine dehydrogenase; Provisional; Region: PRK05367 749927014265 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 749927014266 tetramer interface [polypeptide binding]; other site 749927014267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927014268 catalytic residue [active] 749927014269 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 749927014270 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927014271 catalytic residue [active] 749927014272 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927014273 DNA binding residues [nucleotide binding] 749927014274 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927014275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927014276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927014277 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 749927014278 catalytic residues [active] 749927014279 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927014280 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 749927014281 DNA binding residues [nucleotide binding] 749927014282 putative dimer interface [polypeptide binding]; other site 749927014283 Bifunctional nuclease; Region: DNase-RNase; pfam02577 749927014284 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 749927014285 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927014286 DNA binding residues [nucleotide binding] 749927014287 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927014288 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 749927014289 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 749927014290 phosphopeptide binding site; other site 749927014291 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 749927014292 lipoyl attachment site [posttranslational modification]; other site 749927014293 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 749927014294 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 749927014295 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927014296 acyl-activating enzyme (AAE) consensus motif; other site 749927014297 AMP binding site [chemical binding]; other site 749927014298 active site 749927014299 CoA binding site [chemical binding]; other site 749927014300 enoyl-CoA hydratase; Provisional; Region: PRK06142 749927014301 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927014302 substrate binding site [chemical binding]; other site 749927014303 oxyanion hole (OAH) forming residues; other site 749927014304 trimer interface [polypeptide binding]; other site 749927014305 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927014306 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927014307 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 749927014308 siroheme synthase; Provisional; Region: cysG; PRK10637 749927014309 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 749927014310 active site 749927014311 SAM binding site [chemical binding]; other site 749927014312 homodimer interface [polypeptide binding]; other site 749927014313 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 749927014314 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 749927014315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927014316 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 749927014317 Walker A motif; other site 749927014318 ATP binding site [chemical binding]; other site 749927014319 Walker B motif; other site 749927014320 arginine finger; other site 749927014321 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 749927014322 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 749927014323 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 749927014324 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927014325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927014326 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927014327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927014328 putative substrate translocation pore; other site 749927014329 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 749927014330 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 749927014331 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 749927014332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927014333 catalytic residue [active] 749927014334 MFS/sugar transport protein; Region: MFS_2; pfam13347 749927014335 putative symporter YagG; Provisional; Region: PRK09669; cl15392 749927014336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927014337 putative substrate translocation pore; other site 749927014338 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927014339 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927014340 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 749927014341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927014342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927014343 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927014344 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927014345 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927014346 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 749927014347 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 749927014348 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 749927014349 active site 749927014350 putative catalytic site [active] 749927014351 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 749927014352 active site 749927014353 dimer interface [polypeptide binding]; other site 749927014354 non-prolyl cis peptide bond; other site 749927014355 insertion regions; other site 749927014356 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 749927014357 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749927014358 substrate binding pocket [chemical binding]; other site 749927014359 membrane-bound complex binding site; other site 749927014360 hinge residues; other site 749927014361 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 749927014362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927014363 Walker A/P-loop; other site 749927014364 ATP binding site [chemical binding]; other site 749927014365 Q-loop/lid; other site 749927014366 ABC transporter signature motif; other site 749927014367 Walker B; other site 749927014368 D-loop; other site 749927014369 H-loop/switch region; other site 749927014370 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749927014371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927014372 dimer interface [polypeptide binding]; other site 749927014373 conserved gate region; other site 749927014374 putative PBP binding loops; other site 749927014375 ABC-ATPase subunit interface; other site 749927014376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 749927014377 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 749927014378 active site 749927014379 motif 3; other site 749927014380 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 749927014381 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927014382 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927014383 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927014384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927014385 Walker A/P-loop; other site 749927014386 ATP binding site [chemical binding]; other site 749927014387 Q-loop/lid; other site 749927014388 ABC transporter signature motif; other site 749927014389 Walker B; other site 749927014390 D-loop; other site 749927014391 H-loop/switch region; other site 749927014392 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927014393 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927014394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927014395 Walker A/P-loop; other site 749927014396 ATP binding site [chemical binding]; other site 749927014397 Q-loop/lid; other site 749927014398 ABC transporter signature motif; other site 749927014399 Walker B; other site 749927014400 D-loop; other site 749927014401 H-loop/switch region; other site 749927014402 MbtH-like protein; Region: MbtH; cl01279 749927014403 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 749927014404 intersubunit interface [polypeptide binding]; other site 749927014405 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 749927014406 tetramerization interface [polypeptide binding]; other site 749927014407 active site 749927014408 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927014409 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927014410 acyl-activating enzyme (AAE) consensus motif; other site 749927014411 AMP binding site [chemical binding]; other site 749927014412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927014413 S-adenosylmethionine binding site [chemical binding]; other site 749927014414 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927014415 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927014416 Condensation domain; Region: Condensation; pfam00668 749927014417 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927014418 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927014419 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927014420 acyl-activating enzyme (AAE) consensus motif; other site 749927014421 AMP binding site [chemical binding]; other site 749927014422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927014423 S-adenosylmethionine binding site [chemical binding]; other site 749927014424 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927014425 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927014426 Condensation domain; Region: Condensation; pfam00668 749927014427 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927014428 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927014429 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927014430 acyl-activating enzyme (AAE) consensus motif; other site 749927014431 AMP binding site [chemical binding]; other site 749927014432 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 749927014433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927014434 S-adenosylmethionine binding site [chemical binding]; other site 749927014435 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927014436 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927014437 Condensation domain; Region: Condensation; pfam00668 749927014438 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927014439 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927014440 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927014441 acyl-activating enzyme (AAE) consensus motif; other site 749927014442 AMP binding site [chemical binding]; other site 749927014443 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927014444 Condensation domain; Region: Condensation; pfam00668 749927014445 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927014446 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927014447 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927014448 acyl-activating enzyme (AAE) consensus motif; other site 749927014449 AMP binding site [chemical binding]; other site 749927014450 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927014451 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 749927014452 ABC-ATPase subunit interface; other site 749927014453 dimer interface [polypeptide binding]; other site 749927014454 putative PBP binding regions; other site 749927014455 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 749927014456 ABC-ATPase subunit interface; other site 749927014457 dimer interface [polypeptide binding]; other site 749927014458 putative PBP binding regions; other site 749927014459 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 749927014460 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 749927014461 Walker A/P-loop; other site 749927014462 ATP binding site [chemical binding]; other site 749927014463 Q-loop/lid; other site 749927014464 ABC transporter signature motif; other site 749927014465 Walker B; other site 749927014466 D-loop; other site 749927014467 H-loop/switch region; other site 749927014468 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927014469 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 749927014470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927014471 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 749927014472 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 749927014473 active site 749927014474 substrate binding site [chemical binding]; other site 749927014475 cosubstrate binding site; other site 749927014476 catalytic site [active] 749927014477 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 749927014478 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 749927014479 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 749927014480 Melibiase; Region: Melibiase; pfam02065 749927014481 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927014482 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927014483 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927014484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927014485 dimer interface [polypeptide binding]; other site 749927014486 ABC-ATPase subunit interface; other site 749927014487 putative PBP binding loops; other site 749927014488 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927014489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927014490 dimer interface [polypeptide binding]; other site 749927014491 conserved gate region; other site 749927014492 putative PBP binding loops; other site 749927014493 ABC-ATPase subunit interface; other site 749927014494 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 749927014495 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749927014496 ABC transporter; Region: ABC_tran_2; pfam12848 749927014497 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749927014498 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749927014499 G1 box; other site 749927014500 GTP/Mg2+ binding site [chemical binding]; other site 749927014501 G2 box; other site 749927014502 Switch I region; other site 749927014503 G3 box; other site 749927014504 Switch II region; other site 749927014505 PaaX-like protein; Region: PaaX; pfam07848 749927014506 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 749927014507 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 749927014508 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927014509 substrate binding site [chemical binding]; other site 749927014510 oxyanion hole (OAH) forming residues; other site 749927014511 trimer interface [polypeptide binding]; other site 749927014512 CBD_II domain; Region: CBD_II; smart00637 749927014513 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927014514 Interdomain contacts; other site 749927014515 Cytokine receptor motif; other site 749927014516 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927014517 Interdomain contacts; other site 749927014518 Cytokine receptor motif; other site 749927014519 Glyco_18 domain; Region: Glyco_18; smart00636 749927014520 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 749927014521 active site 749927014522 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749927014523 DNA binding site [nucleotide binding] 749927014524 active site 749927014525 Int/Topo IB signature motif; other site 749927014526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 749927014527 Transposase; Region: HTH_Tnp_1; cl17663 749927014528 putative transposase OrfB; Reviewed; Region: PHA02517 749927014529 HTH-like domain; Region: HTH_21; pfam13276 749927014530 Integrase core domain; Region: rve; pfam00665 749927014531 Integrase core domain; Region: rve_3; pfam13683 749927014532 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 749927014533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927014534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 749927014535 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 749927014536 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927014537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927014538 binding surface 749927014539 TPR motif; other site 749927014540 Tetratricopeptide repeat; Region: TPR_10; pfam13374 749927014541 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927014542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927014543 binding surface 749927014544 TPR motif; other site 749927014545 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927014546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927014547 binding surface 749927014548 TPR motif; other site 749927014549 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927014550 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927014551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927014552 binding surface 749927014553 TPR motif; other site 749927014554 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927014555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927014556 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749927014557 DNA binding site [nucleotide binding] 749927014558 Int/Topo IB signature motif; other site 749927014559 active site 749927014560 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 749927014561 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 749927014562 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927014563 active site 749927014564 metal binding site [ion binding]; metal-binding site 749927014565 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 749927014566 active site 749927014567 catalytic residues [active] 749927014568 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 749927014569 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927014570 MarR family; Region: MarR_2; pfam12802 749927014571 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927014572 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927014573 nucleotide binding site [chemical binding]; other site 749927014574 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 749927014575 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 749927014576 active site 749927014577 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927014578 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927014579 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927014580 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927014581 Interdomain contacts; other site 749927014582 Cytokine receptor motif; other site 749927014583 Cellulose binding domain; Region: CBM_2; cl17741 749927014584 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 749927014585 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927014586 Interdomain contacts; other site 749927014587 Cytokine receptor motif; other site 749927014588 Cellulose binding domain; Region: CBM_2; cl17741 749927014589 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927014590 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 749927014591 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927014592 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 749927014593 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 749927014594 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 749927014595 metal binding site [ion binding]; metal-binding site 749927014596 substrate binding pocket [chemical binding]; other site 749927014597 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927014598 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927014599 DNA binding site [nucleotide binding] 749927014600 domain linker motif; other site 749927014601 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927014602 dimerization interface [polypeptide binding]; other site 749927014603 ligand binding site [chemical binding]; other site 749927014604 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 749927014605 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 749927014606 metal binding site [ion binding]; metal-binding site 749927014607 substrate binding pocket [chemical binding]; other site 749927014608 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749927014609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927014610 dimer interface [polypeptide binding]; other site 749927014611 conserved gate region; other site 749927014612 putative PBP binding loops; other site 749927014613 ABC-ATPase subunit interface; other site 749927014614 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749927014615 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927014616 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 749927014617 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 749927014618 Walker A/P-loop; other site 749927014619 ATP binding site [chemical binding]; other site 749927014620 Q-loop/lid; other site 749927014621 ABC transporter signature motif; other site 749927014622 Walker B; other site 749927014623 D-loop; other site 749927014624 H-loop/switch region; other site 749927014625 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 749927014626 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927014627 dimerization interface [polypeptide binding]; other site 749927014628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927014629 dimer interface [polypeptide binding]; other site 749927014630 phosphorylation site [posttranslational modification] 749927014631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927014632 ATP binding site [chemical binding]; other site 749927014633 Mg2+ binding site [ion binding]; other site 749927014634 G-X-G motif; other site 749927014635 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927014636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927014637 active site 749927014638 phosphorylation site [posttranslational modification] 749927014639 intermolecular recognition site; other site 749927014640 dimerization interface [polypeptide binding]; other site 749927014641 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927014642 DNA binding site [nucleotide binding] 749927014643 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 749927014644 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927014645 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927014646 putative Zn2+ binding site [ion binding]; other site 749927014647 putative DNA binding site [nucleotide binding]; other site 749927014648 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927014649 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927014650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927014651 putative substrate translocation pore; other site 749927014652 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927014653 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927014654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927014655 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 749927014656 amphipathic channel; other site 749927014657 Asn-Pro-Ala signature motifs; other site 749927014658 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 749927014659 iron-sulfur cluster [ion binding]; other site 749927014660 [2Fe-2S] cluster binding site [ion binding]; other site 749927014661 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 749927014662 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 749927014663 PYR/PP interface [polypeptide binding]; other site 749927014664 dimer interface [polypeptide binding]; other site 749927014665 tetramer interface [polypeptide binding]; other site 749927014666 TPP binding site [chemical binding]; other site 749927014667 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927014668 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 749927014669 TPP-binding site [chemical binding]; other site 749927014670 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927014671 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927014672 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927014673 classical (c) SDRs; Region: SDR_c; cd05233 749927014674 NAD(P) binding site [chemical binding]; other site 749927014675 active site 749927014676 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 749927014677 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 749927014678 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 749927014679 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 749927014680 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927014681 active site 749927014682 metal binding site [ion binding]; metal-binding site 749927014683 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927014684 active site 749927014685 metal binding site [ion binding]; metal-binding site 749927014686 hypothetical protein; Provisional; Region: PRK06847 749927014687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927014688 Putative cyclase; Region: Cyclase; pfam04199 749927014689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927014690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927014691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927014692 dimerization interface [polypeptide binding]; other site 749927014693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927014694 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927014695 putative substrate translocation pore; other site 749927014696 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 749927014697 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927014698 Walker A/P-loop; other site 749927014699 ATP binding site [chemical binding]; other site 749927014700 Q-loop/lid; other site 749927014701 ABC transporter signature motif; other site 749927014702 Walker B; other site 749927014703 D-loop; other site 749927014704 H-loop/switch region; other site 749927014705 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927014706 TM-ABC transporter signature motif; other site 749927014707 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 749927014708 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 749927014709 putative ligand binding site [chemical binding]; other site 749927014710 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927014711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927014712 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927014713 DNA binding residues [nucleotide binding] 749927014714 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 749927014715 peptidase domain interface [polypeptide binding]; other site 749927014716 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 749927014717 active site 749927014718 catalytic triad [active] 749927014719 calcium binding site [ion binding]; other site 749927014720 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 749927014721 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749927014722 active site 749927014723 catalytic triad [active] 749927014724 oxyanion hole [active] 749927014725 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 749927014726 Oxygen evolving enhancer protein 3 (PsbQ); Region: PsbQ; cl05363 749927014727 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 749927014728 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 749927014729 active site 749927014730 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 749927014731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927014732 FeS/SAM binding site; other site 749927014733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927014734 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927014735 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 749927014736 active site 749927014737 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927014738 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 749927014739 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 749927014740 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 749927014741 Cytochrome P450; Region: p450; cl12078 749927014742 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 749927014743 CsbD-like; Region: CsbD; pfam05532 749927014744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927014745 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 749927014746 NAD(P) binding site [chemical binding]; other site 749927014747 active site 749927014748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927014749 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927014750 salt bridge; other site 749927014751 non-specific DNA binding site [nucleotide binding]; other site 749927014752 sequence-specific DNA binding site [nucleotide binding]; other site 749927014753 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 749927014754 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749927014755 G1 box; other site 749927014756 GTP/Mg2+ binding site [chemical binding]; other site 749927014757 G2 box; other site 749927014758 Switch I region; other site 749927014759 G3 box; other site 749927014760 Switch II region; other site 749927014761 G4 box; other site 749927014762 G5 box; other site 749927014763 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 749927014764 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 749927014765 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 749927014766 selenocysteine synthase; Provisional; Region: PRK04311 749927014767 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 749927014768 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927014769 selenium donor protein; Region: selD; TIGR00476 749927014770 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 749927014771 dimerization interface [polypeptide binding]; other site 749927014772 putative ATP binding site [chemical binding]; other site 749927014773 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 749927014774 hypothetical protein; Provisional; Region: PRK06771 749927014775 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 749927014776 catalytic triad [active] 749927014777 conserved cis-peptide bond; other site 749927014778 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 749927014779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927014780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927014781 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 749927014782 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 749927014783 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 749927014784 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 749927014785 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927014786 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927014787 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927014788 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927014789 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927014790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927014791 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 749927014792 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927014793 Predicted membrane protein [Function unknown]; Region: COG2259 749927014794 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927014795 active site 749927014796 metal binding site [ion binding]; metal-binding site 749927014797 Peptidase M15; Region: Peptidase_M15_3; cl01194 749927014798 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927014799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927014800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927014801 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 749927014802 Trypsin; Region: Trypsin; pfam00089 749927014803 Sulfatase; Region: Sulfatase; cl19157 749927014804 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 749927014805 VanZ like family; Region: VanZ; cl01971 749927014806 RDD family; Region: RDD; cl00746 749927014807 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 749927014808 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927014809 anti sigma factor interaction site; other site 749927014810 regulatory phosphorylation site [posttranslational modification]; other site 749927014811 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 749927014812 MMPL family; Region: MMPL; cl14618 749927014813 MMPL family; Region: MMPL; cl14618 749927014814 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927014815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927014816 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 749927014817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927014818 S-adenosylmethionine binding site [chemical binding]; other site 749927014819 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 749927014820 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 749927014821 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 749927014822 dimer interface [polypeptide binding]; other site 749927014823 active site 749927014824 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749927014825 catalytic residues [active] 749927014826 substrate binding site [chemical binding]; other site 749927014827 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 749927014828 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927014829 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927014830 putative sugar binding sites [chemical binding]; other site 749927014831 Q-X-W motif; other site 749927014832 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 749927014833 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 749927014834 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927014835 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927014836 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 749927014837 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927014838 acyl-activating enzyme (AAE) consensus motif; other site 749927014839 active site 749927014840 AMP binding site [chemical binding]; other site 749927014841 CoA binding site [chemical binding]; other site 749927014842 TPR repeat; Region: TPR_11; pfam13414 749927014843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927014844 binding surface 749927014845 TPR motif; other site 749927014846 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 749927014847 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927014848 anti sigma factor interaction site; other site 749927014849 regulatory phosphorylation site [posttranslational modification]; other site 749927014850 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927014851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927014852 active site 749927014853 phosphorylation site [posttranslational modification] 749927014854 intermolecular recognition site; other site 749927014855 dimerization interface [polypeptide binding]; other site 749927014856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927014857 PAS domain; Region: PAS_9; pfam13426 749927014858 putative active site [active] 749927014859 heme pocket [chemical binding]; other site 749927014860 PAS domain S-box; Region: sensory_box; TIGR00229 749927014861 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927014862 putative active site [active] 749927014863 heme pocket [chemical binding]; other site 749927014864 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927014865 Histidine kinase; Region: HisKA_3; pfam07730 749927014866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927014867 ATP binding site [chemical binding]; other site 749927014868 Mg2+ binding site [ion binding]; other site 749927014869 G-X-G motif; other site 749927014870 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 749927014871 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927014872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927014873 active site 749927014874 phosphorylation site [posttranslational modification] 749927014875 intermolecular recognition site; other site 749927014876 dimerization interface [polypeptide binding]; other site 749927014877 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927014878 DNA binding residues [nucleotide binding] 749927014879 dimerization interface [polypeptide binding]; other site 749927014880 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 749927014881 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 749927014882 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 749927014883 nucleotide binding site [chemical binding]; other site 749927014884 putative NEF/HSP70 interaction site [polypeptide binding]; other site 749927014885 SBD interface [polypeptide binding]; other site 749927014886 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749927014887 G1 box; other site 749927014888 GTP/Mg2+ binding site [chemical binding]; other site 749927014889 G2 box; other site 749927014890 Switch I region; other site 749927014891 G3 box; other site 749927014892 Switch II region; other site 749927014893 G4 box; other site 749927014894 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 749927014895 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749927014896 G1 box; other site 749927014897 G1 box; other site 749927014898 GTP/Mg2+ binding site [chemical binding]; other site 749927014899 GTP/Mg2+ binding site [chemical binding]; other site 749927014900 G2 box; other site 749927014901 Switch I region; other site 749927014902 G3 box; other site 749927014903 Switch II region; other site 749927014904 G4 box; other site 749927014905 G5 box; other site 749927014906 Predicted ATPase [General function prediction only]; Region: COG3899 749927014907 AAA ATPase domain; Region: AAA_16; pfam13191 749927014908 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927014909 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927014910 DNA binding residues [nucleotide binding] 749927014911 dimerization interface [polypeptide binding]; other site 749927014912 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 749927014913 active site 749927014914 catalytic site [active] 749927014915 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927014916 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927014917 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 749927014918 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 749927014919 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 749927014920 substrate binding pocket [chemical binding]; other site 749927014921 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 749927014922 B12 binding site [chemical binding]; other site 749927014923 cobalt ligand [ion binding]; other site 749927014924 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 749927014925 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 749927014926 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 749927014927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927014928 putative substrate translocation pore; other site 749927014929 Cellulose binding domain; Region: CBM_2; pfam00553 749927014930 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 749927014931 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927014932 putative NAD(P) binding site [chemical binding]; other site 749927014933 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 749927014934 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 749927014935 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927014936 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 749927014937 Cellulose binding domain; Region: CBM_2; pfam00553 749927014938 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927014939 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927014940 active site 749927014941 catalytic tetrad [active] 749927014942 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 749927014943 putative active cleft [active] 749927014944 dimerization interface [polypeptide binding]; other site 749927014945 Chitin binding domain; Region: Chitin_bind_3; pfam03067 749927014946 Cellulose binding domain; Region: CBM_2; pfam00553 749927014947 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927014948 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927014949 DNA binding site [nucleotide binding] 749927014950 domain linker motif; other site 749927014951 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927014952 ligand binding site [chemical binding]; other site 749927014953 dimerization interface [polypeptide binding]; other site 749927014954 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927014955 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927014956 Cellulose binding domain; Region: CBM_2; pfam00553 749927014957 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 749927014958 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 749927014959 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 749927014960 Cellulose binding domain; Region: CBM_2; pfam00553 749927014961 Cellulose binding domain; Region: CBM_2; pfam00553 749927014962 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 749927014963 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927014964 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927014965 DNA binding site [nucleotide binding] 749927014966 domain linker motif; other site 749927014967 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 749927014968 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927014969 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927014970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927014971 dimer interface [polypeptide binding]; other site 749927014972 conserved gate region; other site 749927014973 putative PBP binding loops; other site 749927014974 ABC-ATPase subunit interface; other site 749927014975 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927014976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927014977 dimer interface [polypeptide binding]; other site 749927014978 conserved gate region; other site 749927014979 putative PBP binding loops; other site 749927014980 ABC-ATPase subunit interface; other site 749927014981 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 749927014982 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 749927014983 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 749927014984 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 749927014985 FOG: CBS domain [General function prediction only]; Region: COG0517 749927014986 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 749927014987 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 749927014988 Fe-S cluster binding site [ion binding]; other site 749927014989 active site 749927014990 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 749927014991 nucleotide binding site [chemical binding]; other site 749927014992 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 749927014993 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 749927014994 active site 749927014995 DNA binding site [nucleotide binding] 749927014996 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 749927014997 DNA binding site [nucleotide binding] 749927014998 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 749927014999 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 749927015000 putative DNA binding site [nucleotide binding]; other site 749927015001 putative homodimer interface [polypeptide binding]; other site 749927015002 GAF domain; Region: GAF_2; pfam13185 749927015003 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 749927015004 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927015005 anti sigma factor interaction site; other site 749927015006 regulatory phosphorylation site [posttranslational modification]; other site 749927015007 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927015008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 749927015009 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 749927015010 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927015011 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 749927015012 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927015013 DNA binding residues [nucleotide binding] 749927015014 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 749927015015 putative active site; other site 749927015016 putative metal binding residues [ion binding]; other site 749927015017 signature motif; other site 749927015018 putative triphosphate binding site [ion binding]; other site 749927015019 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 749927015020 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 749927015021 GAF domain; Region: GAF_2; pfam13185 749927015022 ANTAR domain; Region: ANTAR; pfam03861 749927015023 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 749927015024 putative hydrophobic ligand binding site [chemical binding]; other site 749927015025 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 749927015026 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 749927015027 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 749927015028 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927015029 anti sigma factor interaction site; other site 749927015030 regulatory phosphorylation site [posttranslational modification]; other site 749927015031 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 749927015032 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927015033 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927015034 Amidinotransferase; Region: Amidinotransf; cl19186 749927015035 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 749927015036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927015037 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 749927015038 dimerization interface [polypeptide binding]; other site 749927015039 substrate binding pocket [chemical binding]; other site 749927015040 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 749927015041 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 749927015042 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749927015043 catalytic residue [active] 749927015044 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 749927015045 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 749927015046 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 749927015047 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 749927015048 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 749927015049 active site 749927015050 catalytic triad [active] 749927015051 oxyanion hole [active] 749927015052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927015053 metabolite-proton symporter; Region: 2A0106; TIGR00883 749927015054 putative substrate translocation pore; other site 749927015055 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927015056 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927015057 Coenzyme A binding pocket [chemical binding]; other site 749927015058 Radical SAM superfamily; Region: Radical_SAM; pfam04055 749927015059 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 749927015060 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927015061 RHS Repeat; Region: RHS_repeat; pfam05593 749927015062 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 749927015063 RHS Repeat; Region: RHS_repeat; pfam05593 749927015064 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 749927015065 RHS Repeat; Region: RHS_repeat; pfam05593 749927015066 RHS protein; Region: RHS; pfam03527 749927015067 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927015068 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 749927015069 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 749927015070 EspG family; Region: ESX-1_EspG; pfam14011 749927015071 Domain of unknown function (DUF222); Region: DUF222; pfam02720 749927015072 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 749927015073 active site 749927015074 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 749927015075 Flavin Reductases; Region: FlaRed; cl00801 749927015076 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 749927015077 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 749927015078 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 749927015079 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 749927015080 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927015081 catalytic loop [active] 749927015082 iron binding site [ion binding]; other site 749927015083 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 749927015084 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 749927015085 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 749927015086 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 749927015087 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 749927015088 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 749927015089 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927015090 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927015091 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927015092 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927015093 DNA binding site [nucleotide binding] 749927015094 domain linker motif; other site 749927015095 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927015096 dimerization interface [polypeptide binding]; other site 749927015097 ligand binding site [chemical binding]; other site 749927015098 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927015099 sugar binding site [chemical binding]; other site 749927015100 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927015101 sugar binding site [chemical binding]; other site 749927015102 Probable beta-xylosidase; Provisional; Region: PLN03080 749927015103 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 749927015104 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 749927015105 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 749927015106 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927015107 sugar binding site [chemical binding]; other site 749927015108 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927015109 sugar binding site [chemical binding]; other site 749927015110 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 749927015111 active site 749927015112 catalytic residues [active] 749927015113 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927015114 sugar binding site [chemical binding]; other site 749927015115 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927015116 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927015117 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927015118 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 749927015119 dimerization interface [polypeptide binding]; other site 749927015120 active site 749927015121 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 749927015122 substrate binding site [chemical binding]; other site 749927015123 THF binding site; other site 749927015124 zinc-binding site [ion binding]; other site 749927015125 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 749927015126 DNA polymerase IV; Validated; Region: PRK03352 749927015127 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 749927015128 active site 749927015129 DNA binding site [nucleotide binding] 749927015130 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927015131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927015132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927015133 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 749927015134 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927015135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927015136 Coenzyme A binding pocket [chemical binding]; other site 749927015137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927015138 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 749927015139 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 749927015140 homotetramer interface [polypeptide binding]; other site 749927015141 ligand binding site [chemical binding]; other site 749927015142 catalytic site [active] 749927015143 NAD binding site [chemical binding]; other site 749927015144 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 749927015145 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 749927015146 putative DNA binding site [nucleotide binding]; other site 749927015147 putative homodimer interface [polypeptide binding]; other site 749927015148 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927015149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927015150 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 749927015151 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 749927015152 G1 box; other site 749927015153 GTP/Mg2+ binding site [chemical binding]; other site 749927015154 G2 box; other site 749927015155 Switch I region; other site 749927015156 G3 box; other site 749927015157 Switch II region; other site 749927015158 G4 box; other site 749927015159 G5 box; other site 749927015160 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927015161 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 749927015162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927015163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927015164 ATP binding site [chemical binding]; other site 749927015165 Mg2+ binding site [ion binding]; other site 749927015166 G-X-G motif; other site 749927015167 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927015168 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927015169 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927015170 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927015171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927015172 Walker A/P-loop; other site 749927015173 ATP binding site [chemical binding]; other site 749927015174 Q-loop/lid; other site 749927015175 ABC transporter signature motif; other site 749927015176 Walker B; other site 749927015177 D-loop; other site 749927015178 H-loop/switch region; other site 749927015179 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927015180 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927015181 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 749927015182 Walker A/P-loop; other site 749927015183 ATP binding site [chemical binding]; other site 749927015184 Q-loop/lid; other site 749927015185 ABC transporter signature motif; other site 749927015186 Walker B; other site 749927015187 D-loop; other site 749927015188 H-loop/switch region; other site 749927015189 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 749927015190 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 749927015191 active site 749927015192 DNA binding site [nucleotide binding] 749927015193 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 749927015194 DNA binding site [nucleotide binding] 749927015195 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927015196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927015197 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927015198 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927015199 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 749927015200 conserved cys residue [active] 749927015201 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 749927015202 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 749927015203 conserved cys residue [active] 749927015204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927015205 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 749927015206 YibE/F-like protein; Region: YibE_F; pfam07907 749927015207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 749927015208 Nucleolar protein 12 (25kDa); Region: Nop25; pfam09805 749927015209 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 749927015210 active site 749927015211 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 749927015212 AAA domain; Region: AAA_17; pfam13207 749927015213 enoyl-CoA hydratase; Provisional; Region: PRK06127 749927015214 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927015215 substrate binding site [chemical binding]; other site 749927015216 oxyanion hole (OAH) forming residues; other site 749927015217 trimer interface [polypeptide binding]; other site 749927015218 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927015219 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927015220 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 749927015221 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927015222 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927015223 DNA binding residues [nucleotide binding] 749927015224 dimerization interface [polypeptide binding]; other site 749927015225 Cupin domain; Region: Cupin_2; cl17218 749927015226 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 749927015227 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927015228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927015229 putative DNA binding site [nucleotide binding]; other site 749927015230 putative Zn2+ binding site [ion binding]; other site 749927015231 hypothetical protein; Provisional; Region: PRK08204 749927015232 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927015233 active site 749927015234 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 749927015235 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 749927015236 Zn2+ binding site [ion binding]; other site 749927015237 Mg2+ binding site [ion binding]; other site 749927015238 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 749927015239 synthetase active site [active] 749927015240 NTP binding site [chemical binding]; other site 749927015241 metal binding site [ion binding]; metal-binding site 749927015242 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 749927015243 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 749927015244 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927015245 active site 749927015246 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 749927015247 Protein export membrane protein; Region: SecD_SecF; pfam02355 749927015248 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 749927015249 MMPL family; Region: MMPL; cl14618 749927015250 Preprotein translocase subunit; Region: YajC; cl00806 749927015251 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 749927015252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927015253 Walker A motif; other site 749927015254 ATP binding site [chemical binding]; other site 749927015255 Walker B motif; other site 749927015256 arginine finger; other site 749927015257 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 749927015258 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 749927015259 RuvA N terminal domain; Region: RuvA_N; pfam01330 749927015260 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 749927015261 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 749927015262 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 749927015263 active site 749927015264 putative DNA-binding cleft [nucleotide binding]; other site 749927015265 dimer interface [polypeptide binding]; other site 749927015266 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 749927015267 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 749927015268 hypothetical protein; Validated; Region: PRK00110 749927015269 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 749927015270 predicted active site [active] 749927015271 catalytic triad [active] 749927015272 AzlC protein; Region: AzlC; cl00570 749927015273 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927015274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927015275 non-specific DNA binding site [nucleotide binding]; other site 749927015276 salt bridge; other site 749927015277 sequence-specific DNA binding site [nucleotide binding]; other site 749927015278 Cupin domain; Region: Cupin_2; cl17218 749927015279 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927015280 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927015281 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927015282 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927015283 active site 749927015284 Condensation domain; Region: Condensation; cl19241 749927015285 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927015286 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927015287 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927015288 acyl-activating enzyme (AAE) consensus motif; other site 749927015289 AMP binding site [chemical binding]; other site 749927015290 active site 749927015291 CoA binding site [chemical binding]; other site 749927015292 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927015293 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 749927015294 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927015295 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 749927015296 active site 749927015297 multimer interface [polypeptide binding]; other site 749927015298 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927015299 putative DNA binding site [nucleotide binding]; other site 749927015300 putative Zn2+ binding site [ion binding]; other site 749927015301 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927015302 FAD binding domain; Region: FAD_binding_4; pfam01565 749927015303 Berberine and berberine like; Region: BBE; pfam08031 749927015304 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 749927015305 elongation factor G; Reviewed; Region: PRK12740 749927015306 G1 box; other site 749927015307 putative GEF interaction site [polypeptide binding]; other site 749927015308 GTP/Mg2+ binding site [chemical binding]; other site 749927015309 Switch I region; other site 749927015310 G2 box; other site 749927015311 G3 box; other site 749927015312 Switch II region; other site 749927015313 G4 box; other site 749927015314 G5 box; other site 749927015315 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 749927015316 Elongation Factor G, domain II; Region: EFG_II; pfam14492 749927015317 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 749927015318 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 749927015319 XdhC Rossmann domain; Region: XdhC_C; pfam13478 749927015320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927015321 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 749927015322 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 749927015323 putative acyl-acceptor binding pocket; other site 749927015324 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 749927015325 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927015326 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927015327 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 749927015328 nucleotide binding site/active site [active] 749927015329 HIT family signature motif; other site 749927015330 catalytic residue [active] 749927015331 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 749927015332 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 749927015333 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 749927015334 active site 749927015335 dimer interface [polypeptide binding]; other site 749927015336 motif 1; other site 749927015337 motif 2; other site 749927015338 motif 3; other site 749927015339 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 749927015340 anticodon binding site; other site 749927015341 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 749927015342 putative FMN binding site [chemical binding]; other site 749927015343 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 749927015344 CoA binding domain; Region: CoA_binding; cl17356 749927015345 Bacterial sugar transferase; Region: Bac_transf; pfam02397 749927015346 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 749927015347 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749927015348 active site 749927015349 DNA binding site [nucleotide binding] 749927015350 Int/Topo IB signature motif; other site 749927015351 Trypsin; Region: Trypsin; pfam00089 749927015352 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927015353 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 749927015354 protein binding site [polypeptide binding]; other site 749927015355 Peptidase family M41; Region: Peptidase_M41; pfam01434 749927015356 Predicted permease; Region: DUF318; pfam03773 749927015357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927015358 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 749927015359 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927015360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927015361 NAD(P) binding site [chemical binding]; other site 749927015362 active site 749927015363 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 749927015364 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927015365 substrate binding site [chemical binding]; other site 749927015366 oxyanion hole (OAH) forming residues; other site 749927015367 trimer interface [polypeptide binding]; other site 749927015368 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 749927015369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927015370 acyl-activating enzyme (AAE) consensus motif; other site 749927015371 AMP binding site [chemical binding]; other site 749927015372 active site 749927015373 CoA binding site [chemical binding]; other site 749927015374 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 749927015375 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 749927015376 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 749927015377 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 749927015378 metal binding site [ion binding]; metal-binding site 749927015379 dimer interface [polypeptide binding]; other site 749927015380 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927015381 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 749927015382 AsnC family; Region: AsnC_trans_reg; pfam01037 749927015383 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927015384 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927015385 putative DNA binding site [nucleotide binding]; other site 749927015386 putative Zn2+ binding site [ion binding]; other site 749927015387 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927015388 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927015389 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 749927015390 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927015391 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927015392 active site 749927015393 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927015394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927015395 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927015396 DNA binding residues [nucleotide binding] 749927015397 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 749927015398 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 749927015399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927015400 DoxX-like family; Region: DoxX_2; pfam13564 749927015401 AMP-binding domain protein; Validated; Region: PRK07529 749927015402 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927015403 acyl-activating enzyme (AAE) consensus motif; other site 749927015404 AMP binding site [chemical binding]; other site 749927015405 active site 749927015406 CoA binding site [chemical binding]; other site 749927015407 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 749927015408 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 749927015409 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 749927015410 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927015411 active site 749927015412 metal binding site [ion binding]; metal-binding site 749927015413 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 749927015414 putative active site [active] 749927015415 putative metal binding site [ion binding]; other site 749927015416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927015417 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 749927015418 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 749927015419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927015420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927015421 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 749927015422 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 749927015423 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 749927015424 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 749927015425 active site 749927015426 catalytic triad [active] 749927015427 dimer interface [polypeptide binding]; other site 749927015428 Right handed beta helix region; Region: Beta_helix; pfam13229 749927015429 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 749927015430 active site 749927015431 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 749927015432 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 749927015433 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 749927015434 putative ligand binding site [chemical binding]; other site 749927015435 putative NAD binding site [chemical binding]; other site 749927015436 catalytic site [active] 749927015437 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927015438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927015439 dimer interface [polypeptide binding]; other site 749927015440 conserved gate region; other site 749927015441 putative PBP binding loops; other site 749927015442 ABC-ATPase subunit interface; other site 749927015443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927015444 dimer interface [polypeptide binding]; other site 749927015445 conserved gate region; other site 749927015446 putative PBP binding loops; other site 749927015447 ABC-ATPase subunit interface; other site 749927015448 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927015449 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927015450 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 749927015451 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 749927015452 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927015453 ligand binding site [chemical binding]; other site 749927015454 dimerization interface [polypeptide binding]; other site 749927015455 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 749927015456 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 749927015457 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 749927015458 Strictosidine synthase; Region: Str_synth; cl19733 749927015459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927015460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927015461 putative substrate translocation pore; other site 749927015462 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 749927015463 classical (c) SDRs; Region: SDR_c; cd05233 749927015464 NAD(P) binding site [chemical binding]; other site 749927015465 active site 749927015466 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 749927015467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927015468 NAD(P) binding site [chemical binding]; other site 749927015469 active site 749927015470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927015471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927015472 WHG domain; Region: WHG; pfam13305 749927015473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927015474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927015475 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 749927015476 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 749927015477 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927015478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927015479 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 749927015480 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 749927015481 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 749927015482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927015483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927015484 putative substrate translocation pore; other site 749927015485 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927015486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927015487 DNA-binding site [nucleotide binding]; DNA binding site 749927015488 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 749927015489 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 749927015490 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 749927015491 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 749927015492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927015493 Coenzyme A binding pocket [chemical binding]; other site 749927015494 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 749927015495 RHS Repeat; Region: RHS_repeat; pfam05593 749927015496 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 749927015497 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927015498 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 749927015499 RHS Repeat; Region: RHS_repeat; pfam05593 749927015500 RHS Repeat; Region: RHS_repeat; pfam05593 749927015501 RHS Repeat; Region: RHS_repeat; pfam05593 749927015502 RHS Repeat; Region: RHS_repeat; pfam05593 749927015503 RHS Repeat; Region: RHS_repeat; pfam05593 749927015504 RHS Repeat; Region: RHS_repeat; pfam05593 749927015505 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927015506 pyranose oxidase; Region: pyranose_ox; TIGR02462 749927015507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927015508 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927015509 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 749927015510 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 749927015511 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 749927015512 substrate binding site; other site 749927015513 tetramer interface; other site 749927015514 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927015515 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927015516 acyl-activating enzyme (AAE) consensus motif; other site 749927015517 AMP binding site [chemical binding]; other site 749927015518 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927015519 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 749927015520 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927015521 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927015522 Condensation domain; Region: Condensation; cl19241 749927015523 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927015524 Neocarzinostatin family; Region: Neocarzinostat; pfam00960 749927015525 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927015526 homodimer interface [polypeptide binding]; other site 749927015527 active site 749927015528 TDP-binding site; other site 749927015529 acceptor substrate-binding pocket; other site 749927015530 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927015531 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 749927015532 O-methyltransferase; Region: Methyltransf_2; pfam00891 749927015533 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 749927015534 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 749927015535 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927015536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927015537 active site 749927015538 phosphorylation site [posttranslational modification] 749927015539 intermolecular recognition site; other site 749927015540 dimerization interface [polypeptide binding]; other site 749927015541 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927015542 DNA binding residues [nucleotide binding] 749927015543 dimerization interface [polypeptide binding]; other site 749927015544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927015545 Histidine kinase; Region: HisKA_3; pfam07730 749927015546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927015547 ATP binding site [chemical binding]; other site 749927015548 Mg2+ binding site [ion binding]; other site 749927015549 G-X-G motif; other site 749927015550 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927015551 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 749927015552 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927015553 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927015554 Walker A/P-loop; other site 749927015555 ATP binding site [chemical binding]; other site 749927015556 Q-loop/lid; other site 749927015557 ABC transporter signature motif; other site 749927015558 Walker B; other site 749927015559 D-loop; other site 749927015560 H-loop/switch region; other site 749927015561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927015562 active site 749927015563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927015564 Methyltransferase domain; Region: Methyltransf_24; pfam13578 749927015565 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927015566 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927015567 acyl-activating enzyme (AAE) consensus motif; other site 749927015568 AMP binding site [chemical binding]; other site 749927015569 active site 749927015570 CoA binding site [chemical binding]; other site 749927015571 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927015572 Condensation domain; Region: Condensation; cl19241 749927015573 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927015574 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927015575 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927015576 homodimer interface [polypeptide binding]; other site 749927015577 active site 749927015578 TDP-binding site; other site 749927015579 acceptor substrate-binding pocket; other site 749927015580 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927015581 homodimer interface [polypeptide binding]; other site 749927015582 active site 749927015583 TDP-binding site; other site 749927015584 acceptor substrate-binding pocket; other site 749927015585 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927015586 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927015587 homodimer interface [polypeptide binding]; other site 749927015588 active site 749927015589 TDP-binding site; other site 749927015590 acceptor substrate-binding pocket; other site 749927015591 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927015592 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927015593 homodimer interface [polypeptide binding]; other site 749927015594 active site 749927015595 TDP-binding site; other site 749927015596 acceptor substrate-binding pocket; other site 749927015597 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927015598 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927015599 homodimer interface [polypeptide binding]; other site 749927015600 active site 749927015601 TDP-binding site; other site 749927015602 acceptor substrate-binding pocket; other site 749927015603 ABC-2 type transporter; Region: ABC2_membrane; cl17235 749927015604 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927015605 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927015606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927015607 Walker A/P-loop; other site 749927015608 ATP binding site [chemical binding]; other site 749927015609 Q-loop/lid; other site 749927015610 ABC transporter signature motif; other site 749927015611 Walker B; other site 749927015612 D-loop; other site 749927015613 H-loop/switch region; other site 749927015614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927015615 S-adenosylmethionine binding site [chemical binding]; other site 749927015616 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927015617 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927015618 homodimer interface [polypeptide binding]; other site 749927015619 active site 749927015620 TDP-binding site; other site 749927015621 acceptor substrate-binding pocket; other site 749927015622 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927015623 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927015624 homodimer interface [polypeptide binding]; other site 749927015625 active site 749927015626 TDP-binding site; other site 749927015627 acceptor substrate-binding pocket; other site 749927015628 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 749927015629 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 749927015630 inhibitor-cofactor binding pocket; inhibition site 749927015631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927015632 catalytic residue [active] 749927015633 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 749927015634 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927015635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927015636 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927015637 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927015638 homodimer interface [polypeptide binding]; other site 749927015639 active site 749927015640 TDP-binding site; other site 749927015641 acceptor substrate-binding pocket; other site 749927015642 phosphoenolpyruvate synthase; Validated; Region: PRK06241 749927015643 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 749927015644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927015645 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 749927015646 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 749927015647 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 749927015648 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 749927015649 SchA/CurD like domain; Region: SchA_CurD; pfam04486 749927015650 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927015651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927015652 NAD(P) binding site [chemical binding]; other site 749927015653 active site 749927015654 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 749927015655 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 749927015656 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 749927015657 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927015658 classical (c) SDRs; Region: SDR_c; cd05233 749927015659 NAD(P) binding site [chemical binding]; other site 749927015660 active site 749927015661 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 749927015662 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 749927015663 putative hydrophobic ligand binding site [chemical binding]; other site 749927015664 active site 749927015665 catalytic residues_2 [active] 749927015666 catalytic residues_1 [active] 749927015667 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927015668 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 749927015669 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 749927015670 active site 749927015671 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 749927015672 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 749927015673 dimer interface [polypeptide binding]; other site 749927015674 active site 749927015675 Cupin domain; Region: Cupin_2; pfam07883 749927015676 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 749927015677 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927015678 POT family; Region: PTR2; cl17359 749927015679 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 749927015680 O-methyltransferase; Region: Methyltransf_2; pfam00891 749927015681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927015682 S-adenosylmethionine binding site [chemical binding]; other site 749927015683 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927015684 hypothetical protein; Provisional; Region: PRK06126 749927015685 hypothetical protein; Provisional; Region: PRK06126 749927015686 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927015687 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 749927015688 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 749927015689 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 749927015690 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 749927015691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927015692 short chain dehydrogenase; Region: adh_short; pfam00106 749927015693 NAD(P) binding site [chemical binding]; other site 749927015694 active site 749927015695 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927015696 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927015697 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927015698 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927015699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927015700 S-adenosylmethionine binding site [chemical binding]; other site 749927015701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927015702 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927015703 NAD(P) binding site [chemical binding]; other site 749927015704 active site 749927015705 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927015706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927015707 NAD(P) binding site [chemical binding]; other site 749927015708 active site 749927015709 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 749927015710 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 749927015711 Ricin-type beta-trefoil; Region: RICIN; smart00458 749927015712 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927015713 putative sugar binding sites [chemical binding]; other site 749927015714 Q-X-W motif; other site 749927015715 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927015716 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927015717 non-specific DNA binding site [nucleotide binding]; other site 749927015718 salt bridge; other site 749927015719 sequence-specific DNA binding site [nucleotide binding]; other site 749927015720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927015721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927015722 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927015723 binding surface 749927015724 TPR motif; other site 749927015725 Proteins of 100 residues with WXG; Region: WXG100; cl02005 749927015726 RHS Repeat; Region: RHS_repeat; pfam05593 749927015727 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927015728 RHS Repeat; Region: RHS_repeat; pfam05593 749927015729 RHS Repeat; Region: RHS_repeat; pfam05593 749927015730 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 749927015731 RHS Repeat; Region: RHS_repeat; pfam05593 749927015732 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927015733 Nitroreductase family; Region: Nitroreductase; pfam00881 749927015734 dimer interface [polypeptide binding]; other site 749927015735 Short C-terminal domain; Region: SHOCT; pfam09851 749927015736 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927015737 dimerization interface [polypeptide binding]; other site 749927015738 putative DNA binding site [nucleotide binding]; other site 749927015739 putative Zn2+ binding site [ion binding]; other site 749927015740 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 749927015741 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 749927015742 Sulfate transporter family; Region: Sulfate_transp; cl19250 749927015743 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 749927015744 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749927015745 Ligand Binding Site [chemical binding]; other site 749927015746 Nitroreductase family; Region: Nitroreductase; pfam00881 749927015747 FMN binding site [chemical binding]; other site 749927015748 dimer interface [polypeptide binding]; other site 749927015749 Nitroreductase family; Region: Nitroreductase; pfam00881 749927015750 dimer interface [polypeptide binding]; other site 749927015751 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749927015752 Ligand Binding Site [chemical binding]; other site 749927015753 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 749927015754 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 749927015755 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 749927015756 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 749927015757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927015758 motif II; other site 749927015759 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 749927015760 Acetokinase family; Region: Acetate_kinase; cl17229 749927015761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927015762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927015763 Coenzyme A binding pocket [chemical binding]; other site 749927015764 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 749927015765 CoA binding domain; Region: CoA_binding_2; pfam13380 749927015766 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 749927015767 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 749927015768 GAF domain; Region: GAF_2; pfam13185 749927015769 GAF domain; Region: GAF; cl17456 749927015770 Histidine kinase; Region: HisKA_3; pfam07730 749927015771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927015772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927015773 ATP binding site [chemical binding]; other site 749927015774 Mg2+ binding site [ion binding]; other site 749927015775 G-X-G motif; other site 749927015776 hypothetical protein; Provisional; Region: PRK07877 749927015777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927015778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927015779 active site 749927015780 phosphorylation site [posttranslational modification] 749927015781 intermolecular recognition site; other site 749927015782 dimerization interface [polypeptide binding]; other site 749927015783 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927015784 DNA binding residues [nucleotide binding] 749927015785 dimerization interface [polypeptide binding]; other site 749927015786 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 749927015787 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 749927015788 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 749927015789 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 749927015790 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 749927015791 Walker A/P-loop; other site 749927015792 ATP binding site [chemical binding]; other site 749927015793 Q-loop/lid; other site 749927015794 ABC transporter signature motif; other site 749927015795 Walker B; other site 749927015796 D-loop; other site 749927015797 H-loop/switch region; other site 749927015798 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 749927015799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927015800 Walker A/P-loop; other site 749927015801 ATP binding site [chemical binding]; other site 749927015802 Q-loop/lid; other site 749927015803 ABC transporter signature motif; other site 749927015804 Walker B; other site 749927015805 D-loop; other site 749927015806 H-loop/switch region; other site 749927015807 putative phosphoketolase; Provisional; Region: PRK05261 749927015808 XFP N-terminal domain; Region: XFP_N; pfam09364 749927015809 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 749927015810 XFP C-terminal domain; Region: XFP_C; pfam09363 749927015811 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749927015812 Ligand Binding Site [chemical binding]; other site 749927015813 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749927015814 Ligand Binding Site [chemical binding]; other site 749927015815 FOG: CBS domain [General function prediction only]; Region: COG0517 749927015816 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 749927015817 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749927015818 Ligand Binding Site [chemical binding]; other site 749927015819 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749927015820 Ligand Binding Site [chemical binding]; other site 749927015821 FOG: CBS domain [General function prediction only]; Region: COG0517 749927015822 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 749927015823 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749927015824 Ligand Binding Site [chemical binding]; other site 749927015825 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 749927015826 Ligand Binding Site [chemical binding]; other site 749927015827 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927015828 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 749927015829 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 749927015830 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 749927015831 Histidine kinase; Region: HisKA_3; pfam07730 749927015832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927015833 ATP binding site [chemical binding]; other site 749927015834 Mg2+ binding site [ion binding]; other site 749927015835 G-X-G motif; other site 749927015836 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927015837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927015838 active site 749927015839 phosphorylation site [posttranslational modification] 749927015840 intermolecular recognition site; other site 749927015841 dimerization interface [polypeptide binding]; other site 749927015842 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927015843 DNA binding residues [nucleotide binding] 749927015844 dimerization interface [polypeptide binding]; other site 749927015845 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927015846 GAF domain; Region: GAF; pfam01590 749927015847 ANTAR domain; Region: ANTAR; pfam03861 749927015848 CAAX protease self-immunity; Region: Abi; pfam02517 749927015849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927015850 ATP binding site [chemical binding]; other site 749927015851 Mg2+ binding site [ion binding]; other site 749927015852 G-X-G motif; other site 749927015853 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927015854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927015855 active site 749927015856 phosphorylation site [posttranslational modification] 749927015857 intermolecular recognition site; other site 749927015858 dimerization interface [polypeptide binding]; other site 749927015859 Cupin domain; Region: Cupin_2; pfam07883 749927015860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927015861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927015862 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 749927015863 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927015864 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927015865 homodimer interface [polypeptide binding]; other site 749927015866 active site 749927015867 TDP-binding site; other site 749927015868 acceptor substrate-binding pocket; other site 749927015869 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927015870 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927015871 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927015872 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927015873 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927015874 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 749927015875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927015876 Histidine kinase; Region: HisKA_3; pfam07730 749927015877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927015878 ATP binding site [chemical binding]; other site 749927015879 Mg2+ binding site [ion binding]; other site 749927015880 G-X-G motif; other site 749927015881 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927015882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927015883 active site 749927015884 phosphorylation site [posttranslational modification] 749927015885 intermolecular recognition site; other site 749927015886 dimerization interface [polypeptide binding]; other site 749927015887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927015888 DNA binding residues [nucleotide binding] 749927015889 dimerization interface [polypeptide binding]; other site 749927015890 Poly [ADP-ribose] polymerase; Provisional; Region: PLN03122 749927015891 Right handed beta helix region; Region: Beta_helix; pfam13229 749927015892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 749927015893 DNA-binding site [nucleotide binding]; DNA binding site 749927015894 AAA domain; Region: AAA_17; cl19128 749927015895 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927015896 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927015897 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 749927015898 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 749927015899 Catalytic site [active] 749927015900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927015901 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927015902 catalytic core [active] 749927015903 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927015904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 749927015905 Transposase; Region: HTH_Tnp_1; cl17663 749927015906 putative transposase OrfB; Reviewed; Region: PHA02517 749927015907 HTH-like domain; Region: HTH_21; pfam13276 749927015908 Integrase core domain; Region: rve; pfam00665 749927015909 Integrase core domain; Region: rve_3; pfam13683 749927015910 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 749927015911 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927015912 RHS Repeat; Region: RHS_repeat; pfam05593 749927015913 RHS Repeat; Region: RHS_repeat; pfam05593 749927015914 RHS Repeat; Region: RHS_repeat; pfam05593 749927015915 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927015916 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 749927015917 protein-splicing catalytic site; other site 749927015918 thioester formation/cholesterol transfer; other site 749927015919 Pretoxin HINT domain; Region: PT-HINT; pfam07591 749927015920 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927015921 calcium mediated ligand binding site; other site 749927015922 intermolecular salt bridges; other site 749927015923 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927015924 calcium mediated ligand binding site; other site 749927015925 intermolecular salt bridges; other site 749927015926 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927015927 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927015928 Fructosamine kinase; Region: Fructosamin_kin; cl17579 749927015929 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927015930 active site 749927015931 metal binding site [ion binding]; metal-binding site 749927015932 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 749927015933 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; cl19223 749927015934 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927015935 metal binding site [ion binding]; metal-binding site 749927015936 active site 749927015937 I-site; other site 749927015938 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927015939 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927015940 putative sugar binding sites [chemical binding]; other site 749927015941 Q-X-W motif; other site 749927015942 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 749927015943 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 749927015944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927015945 putative substrate translocation pore; other site 749927015946 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 749927015947 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 749927015948 active site 749927015949 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749927015950 dimer interface [polypeptide binding]; other site 749927015951 catalytic residues [active] 749927015952 substrate binding site [chemical binding]; other site 749927015953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927015954 Coenzyme A binding pocket [chemical binding]; other site 749927015955 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 749927015956 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 749927015957 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 749927015958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927015959 active site 749927015960 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 749927015961 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927015962 active site 749927015963 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 749927015964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927015965 Walker A/P-loop; other site 749927015966 ATP binding site [chemical binding]; other site 749927015967 Q-loop/lid; other site 749927015968 ABC transporter signature motif; other site 749927015969 Walker B; other site 749927015970 D-loop; other site 749927015971 H-loop/switch region; other site 749927015972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927015973 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 749927015974 Walker A/P-loop; other site 749927015975 ATP binding site [chemical binding]; other site 749927015976 Q-loop/lid; other site 749927015977 ABC transporter signature motif; other site 749927015978 Walker B; other site 749927015979 D-loop; other site 749927015980 H-loop/switch region; other site 749927015981 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 749927015982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927015983 S-adenosylmethionine binding site [chemical binding]; other site 749927015984 hypothetical protein; Provisional; Region: PRK07236 749927015985 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927015986 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927015987 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927015988 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 749927015989 hypothetical protein; Reviewed; Region: PRK09565 749927015990 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 749927015991 Cytochrome P450; Region: p450; cl12078 749927015992 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927015993 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 749927015994 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927015995 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927015996 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927015997 benzoate transport; Region: 2A0115; TIGR00895 749927015998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927015999 putative substrate translocation pore; other site 749927016000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927016001 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927016002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927016003 binding surface 749927016004 TPR motif; other site 749927016005 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927016006 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927016007 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927016008 binding surface 749927016009 TPR motif; other site 749927016010 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927016011 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927016012 Transcriptional regulator PadR-like family; Region: PadR; cl17335 749927016013 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927016014 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927016015 ANTAR domain; Region: ANTAR; pfam03861 749927016016 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 749927016017 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 749927016018 active site 749927016019 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 749927016020 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927016021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927016022 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 749927016023 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 749927016024 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 749927016025 GAF domain; Region: GAF_3; pfam13492 749927016026 Histidine kinase; Region: HisKA_3; pfam07730 749927016027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927016028 ATP binding site [chemical binding]; other site 749927016029 Mg2+ binding site [ion binding]; other site 749927016030 G-X-G motif; other site 749927016031 hypothetical protein; Provisional; Region: PRK07877 749927016032 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927016033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927016034 active site 749927016035 phosphorylation site [posttranslational modification] 749927016036 intermolecular recognition site; other site 749927016037 dimerization interface [polypeptide binding]; other site 749927016038 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927016039 DNA binding residues [nucleotide binding] 749927016040 dimerization interface [polypeptide binding]; other site 749927016041 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 749927016042 BON domain; Region: BON; pfam04972 749927016043 BON domain; Region: BON; pfam04972 749927016044 BON domain; Region: BON; pfam04972 749927016045 prohibitin homologues; Region: PHB; smart00244 749927016046 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826 749927016047 trimer interface [polypeptide binding]; other site 749927016048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 749927016049 GAF domain; Region: GAF_2; pfam13185 749927016050 ANTAR domain; Region: ANTAR; pfam03861 749927016051 GAF domain; Region: GAF; pfam01590 749927016052 potential frameshift: common BLAST hit: gi|256374809|ref|YP_003098469.1| Stearoyl-CoA 9-desaturase 749927016053 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 749927016054 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 749927016055 Di-iron ligands [ion binding]; other site 749927016056 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 749927016057 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 749927016058 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927016059 anti sigma factor interaction site; other site 749927016060 regulatory phosphorylation site [posttranslational modification]; other site 749927016061 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 749927016062 XFP C-terminal domain; Region: XFP_C; pfam09363 749927016063 Patatin-like phospholipase; Region: Patatin; pfam01734 749927016064 nucleophile elbow; other site 749927016065 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927016066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016068 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 749927016069 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927016070 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927016071 putative sugar binding sites [chemical binding]; other site 749927016072 Q-X-W motif; other site 749927016073 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 749927016074 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927016075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927016076 active site 749927016077 phosphorylation site [posttranslational modification] 749927016078 intermolecular recognition site; other site 749927016079 dimerization interface [polypeptide binding]; other site 749927016080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927016081 DNA binding site [nucleotide binding] 749927016082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927016083 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927016084 dimerization interface [polypeptide binding]; other site 749927016085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927016086 dimer interface [polypeptide binding]; other site 749927016087 phosphorylation site [posttranslational modification] 749927016088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927016089 ATP binding site [chemical binding]; other site 749927016090 Mg2+ binding site [ion binding]; other site 749927016091 G-X-G motif; other site 749927016092 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927016093 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 749927016094 putative ADP-binding pocket [chemical binding]; other site 749927016095 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 749927016096 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 749927016097 short chain dehydrogenase; Provisional; Region: PRK06523 749927016098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927016099 NAD(P) binding site [chemical binding]; other site 749927016100 active site 749927016101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016103 potential frameshift: common BLAST hit: gi|226366460|ref|YP_002784243.1| RNA polymerase ECF-type sigma factor 749927016104 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927016105 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927016106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927016107 dimerization interface [polypeptide binding]; other site 749927016108 putative DNA binding site [nucleotide binding]; other site 749927016109 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 749927016110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927016111 motif II; other site 749927016112 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927016113 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927016114 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927016115 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927016116 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927016117 putative sugar binding sites [chemical binding]; other site 749927016118 Q-X-W motif; other site 749927016119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927016120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927016121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927016122 dimerization interface [polypeptide binding]; other site 749927016123 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 749927016124 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 749927016125 NADP binding site [chemical binding]; other site 749927016126 substrate binding site [chemical binding]; other site 749927016127 active site 749927016128 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 749927016129 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 749927016130 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927016131 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927016132 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927016135 short chain dehydrogenase; Region: adh_short; pfam00106 749927016136 NAD(P) binding site [chemical binding]; other site 749927016137 active site 749927016138 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927016139 active site 749927016140 substrate binding site [chemical binding]; other site 749927016141 ATP binding site [chemical binding]; other site 749927016142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927016143 activation loop (A-loop); other site 749927016144 Cellulose binding domain; Region: CBM_2; pfam00553 749927016145 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 749927016146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927016147 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927016148 DNA binding residues [nucleotide binding] 749927016149 Leucine carboxyl methyltransferase; Region: LCM; cl01306 749927016150 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927016151 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 749927016152 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927016153 hypothetical protein; Provisional; Region: PRK06834 749927016154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927016155 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927016156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927016157 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927016158 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927016159 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927016160 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927016161 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927016162 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927016163 active site 749927016164 Probable pheophorbidase; Region: PLN02965; cl17657 749927016165 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927016166 AAA ATPase domain; Region: AAA_16; pfam13191 749927016167 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927016168 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927016169 DNA binding residues [nucleotide binding] 749927016170 dimerization interface [polypeptide binding]; other site 749927016171 AAA ATPase domain; Region: AAA_16; pfam13191 749927016172 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927016173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927016174 DNA binding residues [nucleotide binding] 749927016175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927016176 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 749927016177 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 749927016178 putative heme binding pocket [chemical binding]; other site 749927016179 classical (c) SDRs; Region: SDR_c; cd05233 749927016180 short chain dehydrogenase; Provisional; Region: PRK07041 749927016181 NAD(P) binding site [chemical binding]; other site 749927016182 active site 749927016183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927016184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927016185 putative substrate translocation pore; other site 749927016186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016188 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 749927016189 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927016190 dimerization interface [polypeptide binding]; other site 749927016191 DNA binding residues [nucleotide binding] 749927016192 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 749927016193 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 749927016194 putative active site [active] 749927016195 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 749927016196 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 749927016197 Walker A/P-loop; other site 749927016198 ATP binding site [chemical binding]; other site 749927016199 Q-loop/lid; other site 749927016200 ABC transporter signature motif; other site 749927016201 Walker B; other site 749927016202 D-loop; other site 749927016203 H-loop/switch region; other site 749927016204 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 749927016205 active site 749927016206 catalytic site [active] 749927016207 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 749927016208 Predicted membrane protein [Function unknown]; Region: COG1470 749927016209 WxL domain surface cell wall-binding; Region: WxL; pfam13731 749927016210 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927016211 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927016212 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927016213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927016214 dimer interface [polypeptide binding]; other site 749927016215 conserved gate region; other site 749927016216 putative PBP binding loops; other site 749927016217 ABC-ATPase subunit interface; other site 749927016218 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 749927016219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927016220 dimer interface [polypeptide binding]; other site 749927016221 conserved gate region; other site 749927016222 putative PBP binding loops; other site 749927016223 ABC-ATPase subunit interface; other site 749927016224 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927016225 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 749927016226 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927016227 dimerization interface [polypeptide binding]; other site 749927016228 ligand binding site [chemical binding]; other site 749927016229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927016230 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927016231 dimerization interface [polypeptide binding]; other site 749927016232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927016233 dimer interface [polypeptide binding]; other site 749927016234 phosphorylation site [posttranslational modification] 749927016235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927016236 ATP binding site [chemical binding]; other site 749927016237 Mg2+ binding site [ion binding]; other site 749927016238 G-X-G motif; other site 749927016239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927016240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927016241 active site 749927016242 phosphorylation site [posttranslational modification] 749927016243 intermolecular recognition site; other site 749927016244 dimerization interface [polypeptide binding]; other site 749927016245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927016246 DNA binding site [nucleotide binding] 749927016247 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 749927016248 Ligand binding site; other site 749927016249 Ligand binding site; other site 749927016250 Ligand binding site; other site 749927016251 Putative Catalytic site; other site 749927016252 DXD motif; other site 749927016253 GtrA-like protein; Region: GtrA; pfam04138 749927016254 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 749927016255 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927016256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016257 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 749927016258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927016259 putative substrate translocation pore; other site 749927016260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927016261 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927016262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016264 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927016265 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 749927016266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016270 DDE superfamily endonuclease; Region: DDE_5; cl17874 749927016271 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927016272 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927016273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016275 WHG domain; Region: WHG; pfam13305 749927016276 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 749927016277 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927016278 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927016279 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 749927016280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 749927016281 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 749927016282 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 749927016283 DDE superfamily endonuclease; Region: DDE_5; cl17874 749927016284 YCII-related domain; Region: YCII; cl00999 749927016285 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927016286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927016287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 749927016288 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927016289 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927016290 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 749927016291 catalytic triad [active] 749927016292 conserved cis-peptide bond; other site 749927016293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927016294 NAD(P) binding site [chemical binding]; other site 749927016295 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927016296 Uncharacterized conserved protein [Function unknown]; Region: COG1359 749927016297 hypothetical protein; Provisional; Region: PRK08244 749927016298 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927016299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016301 Cupin domain; Region: Cupin_2; pfam07883 749927016302 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 749927016303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 749927016304 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927016305 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 749927016306 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927016307 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 749927016308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927016309 NAD(P) binding site [chemical binding]; other site 749927016310 active site 749927016311 Cupin domain; Region: Cupin_2; pfam07883 749927016312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927016313 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927016314 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 749927016315 active site 749927016316 metal binding site [ion binding]; metal-binding site 749927016317 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 749927016318 DNA-binding site [nucleotide binding]; DNA binding site 749927016319 RNA-binding motif; other site 749927016320 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 749927016321 DNA-binding site [nucleotide binding]; DNA binding site 749927016322 RNA-binding motif; other site 749927016323 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 749927016324 DNA-binding site [nucleotide binding]; DNA binding site 749927016325 RNA-binding motif; other site 749927016326 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 749927016327 DNA-binding site [nucleotide binding]; DNA binding site 749927016328 RNA-binding motif; other site 749927016329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016331 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 749927016332 putative hydrophobic ligand binding site [chemical binding]; other site 749927016333 short chain dehydrogenase; Region: adh_short; pfam00106 749927016334 classical (c) SDRs; Region: SDR_c; cd05233 749927016335 NAD(P) binding site [chemical binding]; other site 749927016336 active site 749927016337 YCII-related domain; Region: YCII; cl00999 749927016338 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 749927016339 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927016340 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927016341 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927016342 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 749927016343 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 749927016344 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 749927016345 TrkA-C domain; Region: TrkA_C; pfam02080 749927016346 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 749927016347 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 749927016348 D-pathway; other site 749927016349 Putative ubiquinol binding site [chemical binding]; other site 749927016350 Low-spin heme (heme b) binding site [chemical binding]; other site 749927016351 Putative water exit pathway; other site 749927016352 Binuclear center (heme o3/CuB) [ion binding]; other site 749927016353 K-pathway; other site 749927016354 Putative proton exit pathway; other site 749927016355 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 749927016356 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 749927016357 iron-sulfur cluster [ion binding]; other site 749927016358 [2Fe-2S] cluster binding site [ion binding]; other site 749927016359 potential frameshift: common BLAST hit: gi|111018146|ref|YP_701118.1| ubiquinol-cytochrome C reductase cytochrome b subunit 749927016360 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 749927016361 heme bH binding site [chemical binding]; other site 749927016362 Qi binding site; other site 749927016363 intrachain domain interface; other site 749927016364 heme bL binding site [chemical binding]; other site 749927016365 interchain domain interface [polypeptide binding]; other site 749927016366 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 749927016367 Qo binding site; other site 749927016368 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 749927016369 Domain of unknown function (DUF385); Region: DUF385; cl04387 749927016370 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927016371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927016372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016374 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927016375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927016376 active site 749927016377 phosphorylation site [posttranslational modification] 749927016378 intermolecular recognition site; other site 749927016379 dimerization interface [polypeptide binding]; other site 749927016380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927016381 DNA binding site [nucleotide binding] 749927016382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927016383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927016384 dimerization interface [polypeptide binding]; other site 749927016385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927016386 dimer interface [polypeptide binding]; other site 749927016387 phosphorylation site [posttranslational modification] 749927016388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927016389 ATP binding site [chemical binding]; other site 749927016390 Mg2+ binding site [ion binding]; other site 749927016391 G-X-G motif; other site 749927016392 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927016393 dimerization interface [polypeptide binding]; other site 749927016394 putative DNA binding site [nucleotide binding]; other site 749927016395 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927016396 putative Zn2+ binding site [ion binding]; other site 749927016397 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 749927016398 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927016399 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927016400 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 749927016401 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 749927016402 Cl- selectivity filter; other site 749927016403 Cl- binding residues [ion binding]; other site 749927016404 pore gating glutamate residue; other site 749927016405 dimer interface [polypeptide binding]; other site 749927016406 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 749927016407 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 749927016408 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 749927016409 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 749927016410 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 749927016411 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749927016412 molybdopterin cofactor binding site; other site 749927016413 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 749927016414 molybdopterin cofactor binding site; other site 749927016415 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 749927016416 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 749927016417 Polysulphide reductase, NrfD; Region: NrfD; cl19193 749927016418 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 749927016419 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927016420 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 749927016421 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 749927016422 active site 749927016423 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 749927016424 Sulfurtransferase TusA; Region: TusA; pfam01206 749927016425 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 749927016426 dinuclear metal binding motif [ion binding]; other site 749927016427 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 749927016428 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 749927016429 transmembrane helices; other site 749927016430 Citrate transporter; Region: CitMHS; pfam03600 749927016431 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 749927016432 FOG: CBS domain [General function prediction only]; Region: COG0517 749927016433 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 749927016434 Leucine carboxyl methyltransferase; Region: LCM; cl01306 749927016435 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 749927016436 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 749927016437 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 749927016438 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 749927016439 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 749927016440 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 749927016441 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 749927016442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927016443 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927016444 active site 749927016445 catalytic tetrad [active] 749927016446 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927016447 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927016448 NAD(P) binding site [chemical binding]; other site 749927016449 short chain dehydrogenase; Provisional; Region: PRK06180 749927016450 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 749927016451 NADP binding site [chemical binding]; other site 749927016452 active site 749927016453 steroid binding site; other site 749927016454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927016455 salt bridge; other site 749927016456 non-specific DNA binding site [nucleotide binding]; other site 749927016457 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927016458 sequence-specific DNA binding site [nucleotide binding]; other site 749927016459 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927016460 active site 749927016461 catalytic tetrad [active] 749927016462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927016463 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927016464 salt bridge; other site 749927016465 non-specific DNA binding site [nucleotide binding]; other site 749927016466 sequence-specific DNA binding site [nucleotide binding]; other site 749927016467 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 749927016468 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 749927016469 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927016470 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 749927016471 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 749927016472 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 749927016473 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927016474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927016475 dimer interface [polypeptide binding]; other site 749927016476 conserved gate region; other site 749927016477 putative PBP binding loops; other site 749927016478 ABC-ATPase subunit interface; other site 749927016479 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927016480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927016481 dimer interface [polypeptide binding]; other site 749927016482 conserved gate region; other site 749927016483 putative PBP binding loops; other site 749927016484 ABC-ATPase subunit interface; other site 749927016485 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927016486 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927016487 DNA binding site [nucleotide binding] 749927016488 domain linker motif; other site 749927016489 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927016490 dimerization interface [polypeptide binding]; other site 749927016491 ligand binding site [chemical binding]; other site 749927016492 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 749927016493 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927016494 dimerization interface [polypeptide binding]; other site 749927016495 ligand binding site [chemical binding]; other site 749927016496 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 749927016497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927016498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 749927016499 DNA binding residues [nucleotide binding] 749927016500 dimerization interface [polypeptide binding]; other site 749927016501 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927016502 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927016503 DNA binding site [nucleotide binding] 749927016504 domain linker motif; other site 749927016505 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927016506 dimerization interface [polypeptide binding]; other site 749927016507 ligand binding site [chemical binding]; other site 749927016508 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 749927016509 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927016510 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 749927016511 catalytic residues [active] 749927016512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927016513 Helix-turn-helix domain; Region: HTH_18; pfam12833 749927016514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927016515 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 749927016516 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 749927016517 DDE superfamily endonuclease; Region: DDE_5; cl17874 749927016518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927016519 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 749927016520 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 749927016521 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 749927016522 ligand binding site [chemical binding]; other site 749927016523 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927016524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927016525 TPR motif; other site 749927016526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927016527 binding surface 749927016528 TPR motif; other site 749927016529 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 749927016530 active site 749927016531 iron coordination sites [ion binding]; other site 749927016532 substrate binding pocket [chemical binding]; other site 749927016533 CHAT domain; Region: CHAT; cl19248 749927016534 CHAT domain; Region: CHAT; cl19248 749927016535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 749927016536 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 749927016537 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 749927016538 Helicase C-terminal domain; Region: Helicase_C_2; cl17460 749927016539 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 749927016540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 749927016541 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 749927016542 DDE superfamily endonuclease; Region: DDE_5; cl17874 749927016543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 749927016544 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 749927016545 Restriction endonuclease; Region: Mrr_cat; cl19295 749927016546 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 749927016547 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 749927016548 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 749927016549 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 749927016550 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 749927016551 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 749927016552 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 749927016553 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 749927016554 putative transposase OrfB; Reviewed; Region: PHA02517 749927016555 HTH-like domain; Region: HTH_21; pfam13276 749927016556 Integrase core domain; Region: rve; pfam00665 749927016557 Integrase core domain; Region: rve_3; pfam13683 749927016558 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 749927016559 Transposase; Region: HTH_Tnp_1; cl17663 749927016560 Integrase core domain; Region: rve; pfam00665 749927016561 Integrase core domain; Region: rve_3; pfam13683 749927016562 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927016563 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 749927016564 structural tetrad; other site 749927016565 FOG: WD40 repeat [General function prediction only]; Region: COG2319 749927016566 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 749927016567 structural tetrad; other site 749927016568 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 749927016569 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 749927016570 catalytic residues [active] 749927016571 catalytic nucleophile [active] 749927016572 Recombinase; Region: Recombinase; pfam07508 749927016573 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 749927016574 Cellulose binding domain; Region: CBM_2; pfam00553 749927016575 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 749927016576 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 749927016577 putative dimer interface [polypeptide binding]; other site 749927016578 Domain of unknown function (DUF385); Region: DUF385; cl04387 749927016579 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 749927016580 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 749927016581 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927016582 DNA binding residues [nucleotide binding] 749927016583 drug binding residues [chemical binding]; other site 749927016584 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 749927016585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927016586 dimerization interface [polypeptide binding]; other site 749927016587 putative DNA binding site [nucleotide binding]; other site 749927016588 putative Zn2+ binding site [ion binding]; other site 749927016589 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 749927016590 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 749927016591 Leucine-rich repeats; other site 749927016592 Substrate binding site [chemical binding]; other site 749927016593 Leucine rich repeat; Region: LRR_8; pfam13855 749927016594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927016595 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927016596 putative substrate translocation pore; other site 749927016597 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 749927016598 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 749927016599 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 749927016600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016602 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927016603 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927016604 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927016605 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927016606 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 749927016607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927016608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927016609 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927016610 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 749927016611 metal ion-dependent adhesion site (MIDAS); other site 749927016612 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 749927016613 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927016614 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927016615 active site 749927016616 ATP binding site [chemical binding]; other site 749927016617 substrate binding site [chemical binding]; other site 749927016618 activation loop (A-loop); other site 749927016619 Tetratricopeptide repeat; Region: TPR_19; pfam14559 749927016620 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927016621 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927016622 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927016623 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927016624 Walker A/P-loop; other site 749927016625 ATP binding site [chemical binding]; other site 749927016626 Q-loop/lid; other site 749927016627 ABC transporter signature motif; other site 749927016628 Walker B; other site 749927016629 D-loop; other site 749927016630 H-loop/switch region; other site 749927016631 Predicted transcriptional regulators [Transcription]; Region: COG1725 749927016632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927016633 DNA-binding site [nucleotide binding]; DNA binding site 749927016634 Homeodomain-like domain; Region: HTH_32; pfam13565 749927016635 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 749927016636 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 749927016637 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749927016638 PYR/PP interface [polypeptide binding]; other site 749927016639 dimer interface [polypeptide binding]; other site 749927016640 TPP binding site [chemical binding]; other site 749927016641 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927016642 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 749927016643 TPP-binding site [chemical binding]; other site 749927016644 Domain of unknown function (DUF222); Region: DUF222; pfam02720 749927016645 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 749927016646 active site 749927016647 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927016648 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 749927016649 putative DNA binding site [nucleotide binding]; other site 749927016650 putative Zn2+ binding site [ion binding]; other site 749927016651 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 749927016652 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 749927016653 dimer interface [polypeptide binding]; other site 749927016654 PYR/PP interface [polypeptide binding]; other site 749927016655 TPP binding site [chemical binding]; other site 749927016656 substrate binding site [chemical binding]; other site 749927016657 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 749927016658 TPP-binding site [chemical binding]; other site 749927016659 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 749927016660 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927016661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927016662 active site 749927016663 phosphorylation site [posttranslational modification] 749927016664 intermolecular recognition site; other site 749927016665 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 749927016666 DNA binding residues [nucleotide binding] 749927016667 dimerization interface [polypeptide binding]; other site 749927016668 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 749927016669 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927016670 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927016671 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 749927016672 CAAX protease self-immunity; Region: Abi; pfam02517 749927016673 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927016674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927016675 NAD(P) binding site [chemical binding]; other site 749927016676 active site 749927016677 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 749927016678 EamA-like transporter family; Region: EamA; pfam00892 749927016679 EamA-like transporter family; Region: EamA; pfam00892 749927016680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927016681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927016682 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 749927016683 putative dimerization interface [polypeptide binding]; other site 749927016684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927016685 dimerization interface [polypeptide binding]; other site 749927016686 threonine dehydratase; Provisional; Region: PRK08246 749927016687 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927016688 catalytic residue [active] 749927016689 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927016690 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927016691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 749927016692 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 749927016693 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 749927016694 NlpC/P60 family; Region: NLPC_P60; pfam00877 749927016695 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 749927016696 transcription termination factor Rho; Provisional; Region: PRK12608 749927016697 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 749927016698 RNA binding site [nucleotide binding]; other site 749927016699 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 749927016700 Walker A motif; other site 749927016701 ATP binding site [chemical binding]; other site 749927016702 Walker B motif; other site 749927016703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 749927016704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927016705 ATP binding site [chemical binding]; other site 749927016706 Mg2+ binding site [ion binding]; other site 749927016707 G-X-G motif; other site 749927016708 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927016709 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 749927016710 Cellulose binding domain; Region: CBM_2; cl17741 749927016711 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927016712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927016713 non-specific DNA binding site [nucleotide binding]; other site 749927016714 salt bridge; other site 749927016715 sequence-specific DNA binding site [nucleotide binding]; other site 749927016716 short chain dehydrogenase; Provisional; Region: PRK06180 749927016717 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 749927016718 NADP binding site [chemical binding]; other site 749927016719 active site 749927016720 steroid binding site; other site 749927016721 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 749927016722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927016723 NAD(P) binding site [chemical binding]; other site 749927016724 active site 749927016725 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 749927016726 putative substrate binding site [chemical binding]; other site 749927016727 putative ATP binding site [chemical binding]; other site 749927016728 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927016729 catalytic core [active] 749927016730 GAF domain; Region: GAF; pfam01590 749927016731 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927016732 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927016733 anti sigma factor interaction site; other site 749927016734 regulatory phosphorylation site [posttranslational modification]; other site 749927016735 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927016736 anti sigma factor interaction site; other site 749927016737 regulatory phosphorylation site [posttranslational modification]; other site 749927016738 GAF domain; Region: GAF; pfam01590 749927016739 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927016740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927016741 ATP binding site [chemical binding]; other site 749927016742 Mg2+ binding site [ion binding]; other site 749927016743 G-X-G motif; other site 749927016744 PAS fold; Region: PAS_4; pfam08448 749927016745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927016746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927016747 dimer interface [polypeptide binding]; other site 749927016748 phosphorylation site [posttranslational modification] 749927016749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927016750 ATP binding site [chemical binding]; other site 749927016751 Mg2+ binding site [ion binding]; other site 749927016752 G-X-G motif; other site 749927016753 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927016754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927016755 active site 749927016756 phosphorylation site [posttranslational modification] 749927016757 intermolecular recognition site; other site 749927016758 dimerization interface [polypeptide binding]; other site 749927016759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927016760 PAS domain; Region: PAS_9; pfam13426 749927016761 putative active site [active] 749927016762 heme pocket [chemical binding]; other site 749927016763 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927016764 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 749927016765 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927016766 anti sigma factor interaction site; other site 749927016767 regulatory phosphorylation site [posttranslational modification]; other site 749927016768 GAF domain; Region: GAF; pfam01590 749927016769 ANTAR domain; Region: ANTAR; pfam03861 749927016770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927016771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 749927016772 ATP binding site [chemical binding]; other site 749927016773 Mg2+ binding site [ion binding]; other site 749927016774 G-X-G motif; other site 749927016775 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cl07672 749927016776 Domain interface; other site 749927016777 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 749927016778 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 749927016779 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 749927016780 putative ligand binding site [chemical binding]; other site 749927016781 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927016782 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927016783 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927016784 active site 749927016785 catalytic tetrad [active] 749927016786 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 749927016787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927016788 NAD(P) binding site [chemical binding]; other site 749927016789 active site 749927016790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016791 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927016792 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927016793 DNA binding site [nucleotide binding] 749927016794 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 749927016795 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927016796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927016797 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927016798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927016799 binding surface 749927016800 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927016801 TPR motif; other site 749927016802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927016803 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927016804 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927016805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927016806 non-specific DNA binding site [nucleotide binding]; other site 749927016807 salt bridge; other site 749927016808 sequence-specific DNA binding site [nucleotide binding]; other site 749927016809 Flavoprotein; Region: Flavoprotein; cl19190 749927016810 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927016811 Helix-turn-helix domain; Region: HTH_17; pfam12728 749927016812 potential frameshift: common BLAST hit: gi|256380351|ref|YP_003104011.1| integrase family protein 749927016813 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 749927016814 active site 749927016815 catalytic residues [active] 749927016816 DNA binding site [nucleotide binding] 749927016817 Int/Topo IB signature motif; other site 749927016818 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 749927016819 NAD(P) binding site [chemical binding]; other site 749927016820 catalytic residues [active] 749927016821 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 749927016822 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 749927016823 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927016824 non-specific DNA binding site [nucleotide binding]; other site 749927016825 salt bridge; other site 749927016826 sequence-specific DNA binding site [nucleotide binding]; other site 749927016827 2OG-Fe dioxygenase; Region: 2OG-Fe_Oxy_2; cl01794 749927016828 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927016829 anti sigma factor interaction site; other site 749927016830 regulatory phosphorylation site [posttranslational modification]; other site 749927016831 methionine sulfoxide reductase A; Provisional; Region: PRK14054 749927016832 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 749927016833 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 749927016834 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 749927016835 active site 749927016836 Zn binding site [ion binding]; other site 749927016837 Cadherin repeat-like domain; Region: CA_like; cl15786 749927016838 Putative Ig domain; Region: He_PIG; pfam05345 749927016839 OsmC-like protein; Region: OsmC; pfam02566 749927016840 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 749927016841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927016842 Walker A/P-loop; other site 749927016843 ATP binding site [chemical binding]; other site 749927016844 Q-loop/lid; other site 749927016845 ABC transporter signature motif; other site 749927016846 Walker B; other site 749927016847 D-loop; other site 749927016848 H-loop/switch region; other site 749927016849 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 749927016850 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 749927016851 Domain of unknown function (DUF385); Region: DUF385; pfam04075 749927016852 oxidoreductase; Provisional; Region: PRK06196 749927016853 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 749927016854 NAD(P) binding site [chemical binding]; other site 749927016855 active site 749927016856 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927016857 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927016858 active site 749927016859 ATP binding site [chemical binding]; other site 749927016860 substrate binding site [chemical binding]; other site 749927016861 activation loop (A-loop); other site 749927016862 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 749927016863 YCII-related domain; Region: YCII; cl00999 749927016864 YCII-related domain; Region: YCII; cl00999 749927016865 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 749927016866 NAD+ binding site [chemical binding]; other site 749927016867 substrate binding site [chemical binding]; other site 749927016868 Zn binding site [ion binding]; other site 749927016869 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 749927016870 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 749927016871 SLBB domain; Region: SLBB; pfam10531 749927016872 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 749927016873 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 749927016874 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 749927016875 Phosphoesterase family; Region: Phosphoesterase; pfam04185 749927016876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927016877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927016878 putative substrate translocation pore; other site 749927016879 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 749927016880 Tannase and feruloyl esterase; Region: Tannase; pfam07519 749927016881 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927016882 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 749927016883 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927016884 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 749927016885 YcaO-like family; Region: YcaO; pfam02624 749927016886 GAF domain; Region: GAF; pfam01590 749927016887 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927016888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927016889 metabolite-proton symporter; Region: 2A0106; TIGR00883 749927016890 putative substrate translocation pore; other site 749927016891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927016892 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 749927016893 NAD(P) binding site [chemical binding]; other site 749927016894 active site 749927016895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927016896 sequence-specific DNA binding site [nucleotide binding]; other site 749927016897 salt bridge; other site 749927016898 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927016899 active site 749927016900 Predicted transcriptional regulator [Transcription]; Region: COG2378 749927016901 HTH domain; Region: HTH_11; pfam08279 749927016902 WYL domain; Region: WYL; pfam13280 749927016903 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 749927016904 hydrophobic ligand binding site; other site 749927016905 acyl-CoA synthetase; Validated; Region: PRK07788 749927016906 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927016907 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927016908 acyl-activating enzyme (AAE) consensus motif; other site 749927016909 acyl-activating enzyme (AAE) consensus motif; other site 749927016910 AMP binding site [chemical binding]; other site 749927016911 active site 749927016912 CoA binding site [chemical binding]; other site 749927016913 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 749927016914 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927016915 Reovirus outer capsid protein, Sigma 3; Region: Reovirus_cap; pfam00979 749927016916 MoxR-like ATPases [General function prediction only]; Region: COG0714 749927016917 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 749927016918 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 749927016919 metal ion-dependent adhesion site (MIDAS); other site 749927016920 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 749927016921 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927016922 active site 749927016923 metal binding site [ion binding]; metal-binding site 749927016924 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927016925 SCP-2 sterol transfer family; Region: SCP2; pfam02036 749927016926 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 749927016927 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 749927016928 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 749927016929 substrate binding site [chemical binding]; other site 749927016930 catalytic residues [active] 749927016931 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 749927016932 dimer interface [polypeptide binding]; other site 749927016933 NADP binding site [chemical binding]; other site 749927016934 catalytic residues [active] 749927016935 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 749927016936 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 749927016937 active site 749927016938 tetramer interface [polypeptide binding]; other site 749927016939 Class I aldolases; Region: Aldolase_Class_I; cl17187 749927016940 catalytic residue [active] 749927016941 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 749927016942 Na binding site [ion binding]; other site 749927016943 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927016944 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927016945 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927016946 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927016947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927016948 NAD(P) binding site [chemical binding]; other site 749927016949 active site 749927016950 Clp amino terminal domain; Region: Clp_N; pfam02861 749927016951 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 749927016952 DNA-binding interface [nucleotide binding]; DNA binding site 749927016953 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 749927016954 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 749927016955 NodB motif; other site 749927016956 putative active site [active] 749927016957 putative catalytic site [active] 749927016958 putative Zn binding site [ion binding]; other site 749927016959 Histidine kinase; Region: HisKA_3; pfam07730 749927016960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927016961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927016962 active site 749927016963 phosphorylation site [posttranslational modification] 749927016964 intermolecular recognition site; other site 749927016965 dimerization interface [polypeptide binding]; other site 749927016966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927016967 DNA binding residues [nucleotide binding] 749927016968 dimerization interface [polypeptide binding]; other site 749927016969 Phosphotransferase enzyme family; Region: APH; pfam01636 749927016970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927016971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927016972 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 749927016973 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576 749927016974 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 749927016975 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 749927016976 FMN-binding pocket [chemical binding]; other site 749927016977 flavin binding motif; other site 749927016978 phosphate binding motif [ion binding]; other site 749927016979 beta-alpha-beta structure motif; other site 749927016980 NAD binding pocket [chemical binding]; other site 749927016981 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927016982 catalytic loop [active] 749927016983 iron binding site [ion binding]; other site 749927016984 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 749927016985 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 749927016986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927016987 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 749927016988 active site 749927016989 dimer interface [polypeptide binding]; other site 749927016990 metal binding site [ion binding]; metal-binding site 749927016991 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 749927016992 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 749927016993 active site 749927016994 hypothetical protein; Provisional; Region: PRK06126 749927016995 FAD binding domain; Region: FAD_binding_3; pfam01494 749927016996 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 749927016997 active site 749927016998 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 749927016999 Zn binding site [ion binding]; other site 749927017000 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927017001 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927017002 acyl-activating enzyme (AAE) consensus motif; other site 749927017003 AMP binding site [chemical binding]; other site 749927017004 active site 749927017005 CoA binding site [chemical binding]; other site 749927017006 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927017007 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 749927017008 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 749927017009 putative trimer interface [polypeptide binding]; other site 749927017010 putative CoA binding site [chemical binding]; other site 749927017011 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 749927017012 putative trimer interface [polypeptide binding]; other site 749927017013 putative CoA binding site [chemical binding]; other site 749927017014 GTP-binding protein Der; Reviewed; Region: PRK03003 749927017015 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 749927017016 G1 box; other site 749927017017 GTP/Mg2+ binding site [chemical binding]; other site 749927017018 Switch I region; other site 749927017019 G2 box; other site 749927017020 Switch II region; other site 749927017021 G3 box; other site 749927017022 G4 box; other site 749927017023 G5 box; other site 749927017024 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 749927017025 G1 box; other site 749927017026 GTP/Mg2+ binding site [chemical binding]; other site 749927017027 Switch I region; other site 749927017028 G2 box; other site 749927017029 G3 box; other site 749927017030 Switch II region; other site 749927017031 G4 box; other site 749927017032 G5 box; other site 749927017033 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 749927017034 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 749927017035 putative acyl-acceptor binding pocket; other site 749927017036 cytidylate kinase; Provisional; Region: cmk; PRK00023 749927017037 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 749927017038 CMP-binding site; other site 749927017039 The sites determining sugar specificity; other site 749927017040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927017041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927017042 WHG domain; Region: WHG; pfam13305 749927017043 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 749927017044 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 749927017045 TrkA-C domain; Region: TrkA_C; pfam02080 749927017046 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 749927017047 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 749927017048 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 749927017049 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 749927017050 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 749927017051 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749927017052 RNA binding surface [nucleotide binding]; other site 749927017053 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 749927017054 active site 749927017055 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 749927017056 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 749927017057 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927017058 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 749927017059 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 749927017060 P-loop; other site 749927017061 Magnesium ion binding site [ion binding]; other site 749927017062 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 749927017063 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 749927017064 active site 749927017065 DNA binding site [nucleotide binding] 749927017066 Int/Topo IB signature motif; other site 749927017067 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 749927017068 TM2 domain; Region: TM2; pfam05154 749927017069 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 749927017070 dimer interface [polypeptide binding]; other site 749927017071 ADP-ribose binding site [chemical binding]; other site 749927017072 active site 749927017073 nudix motif; other site 749927017074 metal binding site [ion binding]; metal-binding site 749927017075 CTP synthetase; Validated; Region: pyrG; PRK05380 749927017076 CTP synthase N-terminus; Region: CTP_synth_N; pfam06418 749927017077 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 749927017078 active site 749927017079 putative oxyanion hole; other site 749927017080 catalytic triad [active] 749927017081 Acyltransferase family; Region: Acyl_transf_3; pfam01757 749927017082 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927017083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927017084 DNA-binding site [nucleotide binding]; DNA binding site 749927017085 FCD domain; Region: FCD; pfam07729 749927017086 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 749927017087 Na binding site [ion binding]; other site 749927017088 putative substrate binding site [chemical binding]; other site 749927017089 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 749927017090 Alginate lyase; Region: Alginate_lyase; pfam05426 749927017091 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 749927017092 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 749927017093 Thiamine pyrophosphokinase; Region: TPK; cd07995 749927017094 active site 749927017095 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 749927017096 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 749927017097 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927017098 putative NAD(P) binding site [chemical binding]; other site 749927017099 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927017100 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927017101 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 749927017102 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 749927017103 Walker A/P-loop; other site 749927017104 ATP binding site [chemical binding]; other site 749927017105 Q-loop/lid; other site 749927017106 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 749927017107 ABC transporter signature motif; other site 749927017108 Walker B; other site 749927017109 D-loop; other site 749927017110 H-loop/switch region; other site 749927017111 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 749927017112 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 749927017113 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749927017114 RNA binding surface [nucleotide binding]; other site 749927017115 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 749927017116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927017117 S-adenosylmethionine binding site [chemical binding]; other site 749927017118 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 749927017119 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927017120 active site 749927017121 motif I; other site 749927017122 motif II; other site 749927017123 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 749927017124 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 749927017125 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 749927017126 active site 749927017127 HIGH motif; other site 749927017128 dimer interface [polypeptide binding]; other site 749927017129 KMSKS motif; other site 749927017130 S4 RNA-binding domain; Region: S4; smart00363 749927017131 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 749927017132 active site 749927017133 DNA binding site [nucleotide binding] 749927017134 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927017135 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 749927017136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 749927017137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927017138 argininosuccinate lyase; Provisional; Region: PRK00855 749927017139 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 749927017140 active sites [active] 749927017141 tetramer interface [polypeptide binding]; other site 749927017142 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 749927017143 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 749927017144 arginine repressor; Provisional; Region: PRK03341 749927017145 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 749927017146 ornithine carbamoyltransferase; Provisional; Region: PRK00779 749927017147 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 749927017148 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 749927017149 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927017150 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927017151 inhibitor-cofactor binding pocket; inhibition site 749927017152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927017153 catalytic residue [active] 749927017154 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 749927017155 feedback inhibition sensing region; other site 749927017156 homohexameric interface [polypeptide binding]; other site 749927017157 nucleotide binding site [chemical binding]; other site 749927017158 N-acetyl-L-glutamate binding site [chemical binding]; other site 749927017159 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 749927017160 heterotetramer interface [polypeptide binding]; other site 749927017161 active site pocket [active] 749927017162 cleavage site 749927017163 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 749927017164 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 749927017165 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 749927017166 HTH domain; Region: HTH_11; pfam08279 749927017167 Predicted transcriptional regulator [Transcription]; Region: COG2378 749927017168 WYL domain; Region: WYL; pfam13280 749927017169 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 749927017170 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927017171 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927017172 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 749927017173 active site 749927017174 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 749927017175 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 749927017176 putative tRNA-binding site [nucleotide binding]; other site 749927017177 B3/4 domain; Region: B3_4; pfam03483 749927017178 tRNA synthetase B5 domain; Region: B5; smart00874 749927017179 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 749927017180 dimer interface [polypeptide binding]; other site 749927017181 motif 1; other site 749927017182 motif 3; other site 749927017183 motif 2; other site 749927017184 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 749927017185 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 749927017186 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 749927017187 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 749927017188 dimer interface [polypeptide binding]; other site 749927017189 motif 1; other site 749927017190 active site 749927017191 motif 2; other site 749927017192 motif 3; other site 749927017193 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 749927017194 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 749927017195 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 749927017196 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 749927017197 23S rRNA binding site [nucleotide binding]; other site 749927017198 L21 binding site [polypeptide binding]; other site 749927017199 L13 binding site [polypeptide binding]; other site 749927017200 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 749927017201 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 749927017202 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 749927017203 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 749927017204 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927017205 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927017206 DNA-binding site [nucleotide binding]; DNA binding site 749927017207 FCD domain; Region: FCD; pfam07729 749927017208 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 749927017209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927017210 catalytic residue [active] 749927017211 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 749927017212 homotrimer interaction site [polypeptide binding]; other site 749927017213 putative active site [active] 749927017214 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927017215 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927017216 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927017217 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 749927017218 substrate binding site [chemical binding]; other site 749927017219 ATP binding site [chemical binding]; other site 749927017220 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 749927017221 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 749927017222 active site 749927017223 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749927017224 dimer interface [polypeptide binding]; other site 749927017225 substrate binding site [chemical binding]; other site 749927017226 catalytic residue [active] 749927017227 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 749927017228 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 749927017229 active site 749927017230 putative substrate binding pocket [chemical binding]; other site 749927017231 fructuronate transporter; Provisional; Region: PRK10034; cl15264 749927017232 GntP family permease; Region: GntP_permease; pfam02447 749927017233 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 749927017234 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927017235 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927017236 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 749927017237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927017238 dimer interface [polypeptide binding]; other site 749927017239 conserved gate region; other site 749927017240 putative PBP binding loops; other site 749927017241 ABC-ATPase subunit interface; other site 749927017242 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927017243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927017244 dimer interface [polypeptide binding]; other site 749927017245 conserved gate region; other site 749927017246 putative PBP binding loops; other site 749927017247 ABC-ATPase subunit interface; other site 749927017248 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; cl03741 749927017249 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 749927017250 active site 749927017251 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 749927017252 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 749927017253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927017254 active site 749927017255 phosphorylation site [posttranslational modification] 749927017256 intermolecular recognition site; other site 749927017257 dimerization interface [polypeptide binding]; other site 749927017258 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 749927017259 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 749927017260 PAS domain; Region: PAS; smart00091 749927017261 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 749927017262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927017263 ATP binding site [chemical binding]; other site 749927017264 Mg2+ binding site [ion binding]; other site 749927017265 G-X-G motif; other site 749927017266 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 749927017267 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927017268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927017269 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927017270 putative substrate translocation pore; other site 749927017271 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927017272 hydrophobic ligand binding site; other site 749927017273 Putative zinc-finger; Region: zf-HC2; pfam13490 749927017274 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 749927017275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927017276 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927017277 DNA binding residues [nucleotide binding] 749927017278 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927017279 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 749927017280 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927017281 Interdomain contacts; other site 749927017282 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 749927017283 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 749927017284 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 749927017285 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 749927017286 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 749927017287 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 749927017288 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 749927017289 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 749927017290 active site 749927017291 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 749927017292 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 749927017293 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 749927017294 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 749927017295 ligand binding site [chemical binding]; other site 749927017296 flexible hinge region; other site 749927017297 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 749927017298 putative switch regulator; other site 749927017299 non-specific DNA interactions [nucleotide binding]; other site 749927017300 DNA binding site [nucleotide binding] 749927017301 sequence specific DNA binding site [nucleotide binding]; other site 749927017302 putative cAMP binding site [chemical binding]; other site 749927017303 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 749927017304 RNA/DNA hybrid binding site [nucleotide binding]; other site 749927017305 active site 749927017306 SEC-C motif; Region: SEC-C; cl19389 749927017307 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927017308 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927017309 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927017310 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 749927017311 Ca binding site [ion binding]; other site 749927017312 Ca binding site (active) [ion binding]; other site 749927017313 ligand binding site [chemical binding]; other site 749927017314 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 749927017315 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 749927017316 substrate binding pocket [chemical binding]; other site 749927017317 catalytic triad [active] 749927017318 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 749927017319 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 749927017320 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 749927017321 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 749927017322 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927017323 catalytic core [active] 749927017324 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 749927017325 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 749927017326 Helix-turn-helix domain; Region: HTH_18; pfam12833 749927017327 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927017328 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927017329 DNA binding site [nucleotide binding] 749927017330 domain linker motif; other site 749927017331 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927017332 dimerization interface [polypeptide binding]; other site 749927017333 ligand binding site [chemical binding]; other site 749927017334 Helix-turn-helix domain; Region: HTH_17; cl17695 749927017335 RES domain; Region: RES; pfam08808 749927017336 YCII-related domain; Region: YCII; cl00999 749927017337 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 749927017338 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 749927017339 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 749927017340 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 749927017341 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927017342 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 749927017343 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927017344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927017345 Walker A/P-loop; other site 749927017346 ATP binding site [chemical binding]; other site 749927017347 Q-loop/lid; other site 749927017348 ABC transporter signature motif; other site 749927017349 Walker B; other site 749927017350 D-loop; other site 749927017351 H-loop/switch region; other site 749927017352 Transposase; Region: DEDD_Tnp_IS110; pfam01548 749927017353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 749927017354 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 749927017355 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 749927017356 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 749927017357 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 749927017358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927017359 substrate binding site [chemical binding]; other site 749927017360 oxyanion hole (OAH) forming residues; other site 749927017361 trimer interface [polypeptide binding]; other site 749927017362 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927017363 hydrophobic ligand binding site; other site 749927017364 Serine carboxypeptidase S28; Region: Peptidase_S28; cl19554 749927017365 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 749927017366 excinuclease ABC subunit B; Provisional; Region: PRK05298 749927017367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927017368 ATP binding site [chemical binding]; other site 749927017369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927017370 nucleotide binding region [chemical binding]; other site 749927017371 ATP-binding site [chemical binding]; other site 749927017372 Ultra-violet resistance protein B; Region: UvrB; pfam12344 749927017373 UvrB/uvrC motif; Region: UVR; pfam02151 749927017374 Protein of unknown function (DUF402); Region: DUF402; cl00979 749927017375 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 749927017376 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 749927017377 CoA-binding site [chemical binding]; other site 749927017378 GrpB protein; Region: GrpB; pfam04229 749927017379 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 749927017380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927017381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927017382 WHG domain; Region: WHG; pfam13305 749927017383 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 749927017384 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 749927017385 RNA binding site [nucleotide binding]; other site 749927017386 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 749927017387 RNA binding site [nucleotide binding]; other site 749927017388 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 749927017389 RNA binding site [nucleotide binding]; other site 749927017390 S1 RNA binding domain; Region: S1; pfam00575 749927017391 RNA binding site [nucleotide binding]; other site 749927017392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927017393 S-adenosylmethionine binding site [chemical binding]; other site 749927017394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927017395 Coenzyme A binding pocket [chemical binding]; other site 749927017396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927017397 Coenzyme A binding pocket [chemical binding]; other site 749927017398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927017399 Walker A/P-loop; other site 749927017400 ATP binding site [chemical binding]; other site 749927017401 Q-loop/lid; other site 749927017402 ABC transporter signature motif; other site 749927017403 Walker B; other site 749927017404 H-loop/switch region; other site 749927017405 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 749927017406 Predicted membrane protein [Function unknown]; Region: COG1511 749927017407 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 749927017408 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 749927017409 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 749927017410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927017411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927017412 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 749927017413 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 749927017414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927017415 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927017416 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927017417 putative NAD(P) binding site [chemical binding]; other site 749927017418 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927017419 EF-hand domain pair; Region: EF-hand_7; pfam13499 749927017420 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 749927017421 EF-hand domain pair; Region: EF-hand_7; pfam13499 749927017422 Ca2+ binding site [ion binding]; other site 749927017423 DNA polymerase I; Provisional; Region: PRK05755 749927017424 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 749927017425 active site 749927017426 putative 5' ssDNA interaction site; other site 749927017427 metal binding site 3; metal-binding site 749927017428 metal binding site 1 [ion binding]; metal-binding site 749927017429 metal binding site 2 [ion binding]; metal-binding site 749927017430 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 749927017431 putative DNA binding site [nucleotide binding]; other site 749927017432 putative metal binding site [ion binding]; other site 749927017433 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 749927017434 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 749927017435 active site 749927017436 DNA binding site [nucleotide binding] 749927017437 catalytic site [active] 749927017438 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 749927017439 CoenzymeA binding site [chemical binding]; other site 749927017440 subunit interaction site [polypeptide binding]; other site 749927017441 PHB binding site; other site 749927017442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927017443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927017444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927017445 dimerization interface [polypeptide binding]; other site 749927017446 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927017447 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 749927017448 dimerization interface [polypeptide binding]; other site 749927017449 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 749927017450 ligand binding site [chemical binding]; other site 749927017451 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 749927017452 TM-ABC transporter signature motif; other site 749927017453 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 749927017454 TM-ABC transporter signature motif; other site 749927017455 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 749927017456 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 749927017457 Walker A/P-loop; other site 749927017458 ATP binding site [chemical binding]; other site 749927017459 Q-loop/lid; other site 749927017460 ABC transporter signature motif; other site 749927017461 Walker B; other site 749927017462 D-loop; other site 749927017463 H-loop/switch region; other site 749927017464 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 749927017465 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 749927017466 Walker A/P-loop; other site 749927017467 ATP binding site [chemical binding]; other site 749927017468 Q-loop/lid; other site 749927017469 ABC transporter signature motif; other site 749927017470 Walker B; other site 749927017471 D-loop; other site 749927017472 H-loop/switch region; other site 749927017473 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 749927017474 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 749927017475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927017476 active site 749927017477 phosphorylation site [posttranslational modification] 749927017478 intermolecular recognition site; other site 749927017479 dimerization interface [polypeptide binding]; other site 749927017480 ANTAR domain; Region: ANTAR; pfam03861 749927017481 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 749927017482 active site 749927017483 catalytic residues [active] 749927017484 DNA binding site [nucleotide binding] 749927017485 Int/Topo IB signature motif; other site 749927017486 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 749927017487 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 749927017488 cofactor binding site; other site 749927017489 DNA binding site [nucleotide binding] 749927017490 substrate interaction site [chemical binding]; other site 749927017491 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 749927017492 MltA specific insert domain; Region: MltA; cl08398 749927017493 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 749927017494 Ligand Binding Site [chemical binding]; other site 749927017495 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 749927017496 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 749927017497 dimer interface [polypeptide binding]; other site 749927017498 ssDNA binding site [nucleotide binding]; other site 749927017499 tetramer (dimer of dimers) interface [polypeptide binding]; other site 749927017500 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927017501 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 749927017502 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 749927017503 nudix motif; other site 749927017504 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 749927017505 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927017506 DNA-binding site [nucleotide binding]; DNA binding site 749927017507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927017508 Coenzyme A binding pocket [chemical binding]; other site 749927017509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927017510 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 749927017511 DNA binding site [nucleotide binding] 749927017512 active site 749927017513 Int/Topo IB signature motif; other site 749927017514 catalytic residues [active] 749927017515 RNA polymerase factor sigma-70; Validated; Region: PRK08241 749927017516 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927017517 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927017518 DNA binding residues [nucleotide binding] 749927017519 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927017520 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 749927017521 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927017522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927017523 EspG family; Region: ESX-1_EspG; pfam14011 749927017524 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 749927017525 Histidine kinase; Region: HisKA_3; pfam07730 749927017526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927017527 ATP binding site [chemical binding]; other site 749927017528 Mg2+ binding site [ion binding]; other site 749927017529 G-X-G motif; other site 749927017530 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927017531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927017532 active site 749927017533 phosphorylation site [posttranslational modification] 749927017534 intermolecular recognition site; other site 749927017535 dimerization interface [polypeptide binding]; other site 749927017536 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927017537 DNA binding residues [nucleotide binding] 749927017538 dimerization interface [polypeptide binding]; other site 749927017539 RDD family; Region: RDD; pfam06271 749927017540 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 749927017541 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 749927017542 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 749927017543 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927017544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927017545 active site 749927017546 phosphorylation site [posttranslational modification] 749927017547 intermolecular recognition site; other site 749927017548 dimerization interface [polypeptide binding]; other site 749927017549 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927017550 DNA binding residues [nucleotide binding] 749927017551 dimerization interface [polypeptide binding]; other site 749927017552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927017553 Histidine kinase; Region: HisKA_3; pfam07730 749927017554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927017555 ATP binding site [chemical binding]; other site 749927017556 Mg2+ binding site [ion binding]; other site 749927017557 G-X-G motif; other site 749927017558 CHAT domain; Region: CHAT; cl19248 749927017559 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927017560 short chain dehydrogenase; Region: adh_short; pfam00106 749927017561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927017562 NAD(P) binding site [chemical binding]; other site 749927017563 active site 749927017564 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 749927017565 Q-loop/lid; other site 749927017566 ABC transporter signature motif; other site 749927017567 Walker B; other site 749927017568 D-loop; other site 749927017569 H-loop/switch region; other site 749927017570 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 749927017571 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927017572 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927017573 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927017574 DNA binding residues [nucleotide binding] 749927017575 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 749927017576 active site 749927017577 metal binding site [ion binding]; metal-binding site 749927017578 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 749927017579 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 749927017580 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 749927017581 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927017582 NAD(P) binding site [chemical binding]; other site 749927017583 catalytic residues [active] 749927017584 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 749927017585 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 749927017586 active site pocket [active] 749927017587 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 749927017588 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927017589 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927017590 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927017591 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927017592 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 749927017593 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927017594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927017595 non-specific DNA binding site [nucleotide binding]; other site 749927017596 salt bridge; other site 749927017597 sequence-specific DNA binding site [nucleotide binding]; other site 749927017598 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927017599 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927017600 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927017601 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 749927017602 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 749927017603 conserved cys residue [active] 749927017604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927017605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927017606 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927017607 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927017608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 749927017609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927017610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927017611 short chain dehydrogenase; Provisional; Region: PRK12827 749927017612 NAD(P) binding site [chemical binding]; other site 749927017613 active site 749927017614 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927017615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927017616 salt bridge; other site 749927017617 non-specific DNA binding site [nucleotide binding]; other site 749927017618 sequence-specific DNA binding site [nucleotide binding]; other site 749927017619 GAF domain; Region: GAF_2; pfam13185 749927017620 ANTAR domain; Region: ANTAR; pfam03861 749927017621 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 749927017622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927017623 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 749927017624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927017625 DNA binding residues [nucleotide binding] 749927017626 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 749927017627 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 749927017628 metal binding site [ion binding]; metal-binding site 749927017629 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 749927017630 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 749927017631 cysteine synthase; Region: PLN02565 749927017632 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 749927017633 dimer interface [polypeptide binding]; other site 749927017634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927017635 catalytic residue [active] 749927017636 Condensation domain; Region: Condensation; cl19241 749927017637 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 749927017638 Condensation domain; Region: Condensation; pfam00668 749927017639 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927017640 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927017641 Condensation domain; Region: Condensation; pfam00668 749927017642 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927017643 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927017644 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927017645 active site 749927017646 AMP binding site [chemical binding]; other site 749927017647 CoA binding site [chemical binding]; other site 749927017648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927017649 S-adenosylmethionine binding site [chemical binding]; other site 749927017650 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927017651 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927017652 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927017653 acyl-activating enzyme (AAE) consensus motif; other site 749927017654 AMP binding site [chemical binding]; other site 749927017655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927017656 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927017657 putative substrate translocation pore; other site 749927017658 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927017659 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927017660 acyl-activating enzyme (AAE) consensus motif; other site 749927017661 AMP binding site [chemical binding]; other site 749927017662 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927017663 Condensation domain; Region: Condensation; cl19241 749927017664 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927017665 MbtH-like protein; Region: MbtH; cl01279 749927017666 acyl-CoA synthetase; Validated; Region: PRK05850 749927017667 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 749927017668 acyl-activating enzyme (AAE) consensus motif; other site 749927017669 active site 749927017670 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927017671 Condensation domain; Region: Condensation; pfam00668 749927017672 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927017673 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927017674 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927017675 acyl-activating enzyme (AAE) consensus motif; other site 749927017676 AMP binding site [chemical binding]; other site 749927017677 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927017678 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927017679 Amidinotransferase; Region: Amidinotransf; cl19186 749927017680 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927017681 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927017682 acyl-activating enzyme (AAE) consensus motif; other site 749927017683 AMP binding site [chemical binding]; other site 749927017684 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927017685 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927017686 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927017687 Condensation domain; Region: Condensation; pfam00668 749927017688 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927017689 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 749927017690 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 749927017691 acyl-activating enzyme (AAE) consensus motif; other site 749927017692 AMP binding site [chemical binding]; other site 749927017693 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927017694 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927017695 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 749927017696 acyl-activating enzyme (AAE) consensus motif; other site 749927017697 AMP binding site [chemical binding]; other site 749927017698 active site 749927017699 CoA binding site [chemical binding]; other site 749927017700 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927017701 AAA ATPase domain; Region: AAA_16; pfam13191 749927017702 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927017703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927017704 DNA binding residues [nucleotide binding] 749927017705 dimerization interface [polypeptide binding]; other site 749927017706 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 749927017707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927017708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927017709 dimerization interface [polypeptide binding]; other site 749927017710 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 749927017711 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 749927017712 CGNR zinc finger; Region: zf-CGNR; pfam11706 749927017713 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 749927017714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927017715 putative substrate translocation pore; other site 749927017716 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927017717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927017718 NAD(P) binding site [chemical binding]; other site 749927017719 active site 749927017720 cell division protein FtsQ; Provisional; Region: PRK05529 749927017721 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 749927017722 Cell division protein FtsQ; Region: FtsQ; pfam03799 749927017723 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 749927017724 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 749927017725 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749927017726 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749927017727 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 749927017728 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 749927017729 homodimer interface [polypeptide binding]; other site 749927017730 active site 749927017731 cell division protein FtsW; Region: ftsW; TIGR02614 749927017732 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 749927017733 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 749927017734 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749927017735 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749927017736 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 749927017737 Mg++ binding site [ion binding]; other site 749927017738 putative catalytic motif [active] 749927017739 putative substrate binding site [chemical binding]; other site 749927017740 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 749927017741 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 749927017742 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749927017743 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749927017744 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 749927017745 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 749927017746 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749927017747 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749927017748 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 749927017749 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 749927017750 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 749927017751 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 749927017752 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 749927017753 cell division protein MraZ; Reviewed; Region: PRK00326 749927017754 MraZ protein; Region: MraZ; pfam02381 749927017755 MraZ protein; Region: MraZ; pfam02381 749927017756 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927017757 EspG family; Region: ESX-1_EspG; pfam14011 749927017758 PPE family; Region: PPE; pfam00823 749927017759 MoxR-like ATPases [General function prediction only]; Region: COG0714 749927017760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927017761 ATP binding site [chemical binding]; other site 749927017762 Walker A motif; other site 749927017763 Walker B motif; other site 749927017764 arginine finger; other site 749927017765 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 749927017766 Protein of unknown function DUF58; Region: DUF58; pfam01882 749927017767 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 749927017768 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 749927017769 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 749927017770 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 749927017771 active site 749927017772 DNA polymerase IV; Validated; Region: PRK02406 749927017773 DNA binding site [nucleotide binding] 749927017774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927017775 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 749927017776 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 749927017777 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927017778 P-loop; other site 749927017779 Magnesium ion binding site [ion binding]; other site 749927017780 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 749927017781 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 749927017782 putative DNA binding site [nucleotide binding]; other site 749927017783 catalytic residue [active] 749927017784 putative H2TH interface [polypeptide binding]; other site 749927017785 putative catalytic residues [active] 749927017786 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 749927017787 adenosine deaminase; Provisional; Region: PRK09358 749927017788 active site 749927017789 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927017790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927017791 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 749927017792 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 749927017793 quinone interaction residues [chemical binding]; other site 749927017794 active site 749927017795 catalytic residues [active] 749927017796 FMN binding site [chemical binding]; other site 749927017797 substrate binding site [chemical binding]; other site 749927017798 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 749927017799 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 749927017800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927017801 non-specific DNA binding site [nucleotide binding]; other site 749927017802 salt bridge; other site 749927017803 sequence-specific DNA binding site [nucleotide binding]; other site 749927017804 Competence-damaged protein; Region: CinA; pfam02464 749927017805 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 749927017806 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 749927017807 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 749927017808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927017809 FeS/SAM binding site; other site 749927017810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927017811 Coenzyme A binding pocket [chemical binding]; other site 749927017812 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 749927017813 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 749927017814 FMN binding site [chemical binding]; other site 749927017815 dimer interface [polypeptide binding]; other site 749927017816 RloB-like protein; Region: RloB; pfam13707 749927017817 Predicted ATPases [General function prediction only]; Region: COG1106 749927017818 AAA domain; Region: AAA_23; pfam13476 749927017819 Walker A/P-loop; other site 749927017820 ATP binding site [chemical binding]; other site 749927017821 AAA domain; Region: AAA_21; pfam13304 749927017822 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 749927017823 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 749927017824 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927017825 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 749927017826 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 749927017827 putative acyl-acceptor binding pocket; other site 749927017828 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 749927017829 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 749927017830 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 749927017831 EamA-like transporter family; Region: EamA; pfam00892 749927017832 EamA-like transporter family; Region: EamA; pfam00892 749927017833 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 749927017834 Spore germination protein; Region: Spore_permease; cl17796 749927017835 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927017836 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 749927017837 metal ion-dependent adhesion site (MIDAS); other site 749927017838 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 749927017839 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927017840 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 749927017841 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 749927017842 dimer interface [polypeptide binding]; other site 749927017843 active site 749927017844 catalytic residue [active] 749927017845 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927017846 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927017847 active site 749927017848 ATP binding site [chemical binding]; other site 749927017849 substrate binding site [chemical binding]; other site 749927017850 activation loop (A-loop); other site 749927017851 Septum formation; Region: Septum_form; pfam13845 749927017852 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 749927017853 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 749927017854 Uncharacterized conserved protein [Function unknown]; Region: COG3603 749927017855 ACT domain; Region: ACT_7; pfam13840 749927017856 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 749927017857 HicB family; Region: HicB; pfam05534 749927017858 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 749927017859 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 749927017860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 749927017861 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927017862 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927017863 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 749927017864 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927017865 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927017866 non-specific DNA binding site [nucleotide binding]; other site 749927017867 salt bridge; other site 749927017868 sequence-specific DNA binding site [nucleotide binding]; other site 749927017869 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927017870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927017871 LysR substrate binding domain; Region: LysR_substrate; pfam03466 749927017872 dimerization interface [polypeptide binding]; other site 749927017873 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927017874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927017875 TPR motif; other site 749927017876 dihydrodipicolinate reductase; Provisional; Region: PRK00048 749927017877 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 749927017878 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 749927017879 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 749927017880 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 749927017881 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 749927017882 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 749927017883 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 749927017884 oligomer interface [polypeptide binding]; other site 749927017885 RNA binding site [nucleotide binding]; other site 749927017886 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 749927017887 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 749927017888 RNase E interface [polypeptide binding]; other site 749927017889 trimer interface [polypeptide binding]; other site 749927017890 active site 749927017891 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 749927017892 putative nucleic acid binding region [nucleotide binding]; other site 749927017893 G-X-X-G motif; other site 749927017894 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 749927017895 RNA binding site [nucleotide binding]; other site 749927017896 domain interface; other site 749927017897 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 749927017898 16S/18S rRNA binding site [nucleotide binding]; other site 749927017899 S13e-L30e interaction site [polypeptide binding]; other site 749927017900 25S rRNA binding site [nucleotide binding]; other site 749927017901 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 749927017902 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 749927017903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927017904 non-specific DNA binding site [nucleotide binding]; other site 749927017905 salt bridge; other site 749927017906 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 749927017907 sequence-specific DNA binding site [nucleotide binding]; other site 749927017908 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 749927017909 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 749927017910 active site 749927017911 Riboflavin kinase; Region: Flavokinase; smart00904 749927017912 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 749927017913 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 749927017914 RNA binding site [nucleotide binding]; other site 749927017915 active site 749927017916 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 749927017917 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927017918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927017919 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927017920 active site 749927017921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927017922 putative substrate translocation pore; other site 749927017923 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927017924 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 749927017925 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 749927017926 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 749927017927 DHH family; Region: DHH; pfam01368 749927017928 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl19688 749927017929 Methyltransferase domain; Region: Methyltransf_26; pfam13659 749927017930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 749927017931 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 749927017932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927017933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927017934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927017935 S-adenosylmethionine binding site [chemical binding]; other site 749927017936 Putative esterase; Region: Esterase; pfam00756 749927017937 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 749927017938 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 749927017939 Protein of unknown function (DUF503); Region: DUF503; pfam04456 749927017940 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 749927017941 translation initiation factor IF-2; Region: IF-2; TIGR00487 749927017942 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 749927017943 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 749927017944 G1 box; other site 749927017945 putative GEF interaction site [polypeptide binding]; other site 749927017946 GTP/Mg2+ binding site [chemical binding]; other site 749927017947 Switch I region; other site 749927017948 G2 box; other site 749927017949 G3 box; other site 749927017950 Switch II region; other site 749927017951 G4 box; other site 749927017952 G5 box; other site 749927017953 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 749927017954 Translation-initiation factor 2; Region: IF-2; pfam11987 749927017955 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 749927017956 Protein of unknown function (DUF448); Region: DUF448; pfam04296 749927017957 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 749927017958 NusA N-terminal domain; Region: NusA_N; pfam08529 749927017959 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 749927017960 RNA binding site [nucleotide binding]; other site 749927017961 homodimer interface [polypeptide binding]; other site 749927017962 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 749927017963 G-X-X-G motif; other site 749927017964 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 749927017965 G-X-X-G motif; other site 749927017966 ribosome maturation protein RimP; Reviewed; Region: PRK00092 749927017967 heptamer interface [polypeptide binding]; other site 749927017968 Sm1 motif; other site 749927017969 hexamer interface [polypeptide binding]; other site 749927017970 RNA binding site [nucleotide binding]; other site 749927017971 Sm2 motif; other site 749927017972 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 749927017973 dinuclear metal binding motif [ion binding]; other site 749927017974 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927017975 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927017976 catalytic residue [active] 749927017977 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 749927017978 tetramer interface [polypeptide binding]; other site 749927017979 active site 749927017980 Mg2+/Mn2+ binding site [ion binding]; other site 749927017981 Predicted membrane protein [Function unknown]; Region: COG3428 749927017982 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 749927017983 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 749927017984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927017985 Histidine kinase; Region: HisKA_3; pfam07730 749927017986 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 749927017987 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927017988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927017989 active site 749927017990 phosphorylation site [posttranslational modification] 749927017991 intermolecular recognition site; other site 749927017992 dimerization interface [polypeptide binding]; other site 749927017993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927017994 DNA binding residues [nucleotide binding] 749927017995 dimerization interface [polypeptide binding]; other site 749927017996 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 749927017997 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927017998 dimerization interface [polypeptide binding]; other site 749927017999 putative DNA binding site [nucleotide binding]; other site 749927018000 putative Zn2+ binding site [ion binding]; other site 749927018001 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 749927018002 putative hydrophobic ligand binding site [chemical binding]; other site 749927018003 protein interface [polypeptide binding]; other site 749927018004 gate; other site 749927018005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927018006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018007 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 749927018008 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 749927018009 chromosome segregation protein; Provisional; Region: PRK02224 749927018010 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927018011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927018012 active site 749927018013 phosphorylation site [posttranslational modification] 749927018014 intermolecular recognition site; other site 749927018015 dimerization interface [polypeptide binding]; other site 749927018016 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927018017 DNA binding site [nucleotide binding] 749927018018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927018019 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927018020 dimerization interface [polypeptide binding]; other site 749927018021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927018022 dimer interface [polypeptide binding]; other site 749927018023 phosphorylation site [posttranslational modification] 749927018024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927018025 ATP binding site [chemical binding]; other site 749927018026 Mg2+ binding site [ion binding]; other site 749927018027 G-X-G motif; other site 749927018028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927018029 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927018030 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927018031 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927018032 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927018033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927018034 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927018035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927018036 TPR motif; other site 749927018037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927018038 binding surface 749927018039 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927018040 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927018041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927018042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927018043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927018044 dimerization interface [polypeptide binding]; other site 749927018045 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927018046 enoyl-CoA hydratase; Provisional; Region: PRK08252 749927018047 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927018048 substrate binding site [chemical binding]; other site 749927018049 oxyanion hole (OAH) forming residues; other site 749927018050 trimer interface [polypeptide binding]; other site 749927018051 acetoacetate decarboxylase; Provisional; Region: PRK02265 749927018052 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 749927018053 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927018054 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927018055 acyl-coenzyme A oxidase; Region: PLN02526 749927018056 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927018057 active site 749927018058 Transcriptional regulator [Transcription]; Region: LytR; COG1316 749927018059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927018060 short chain dehydrogenase; Region: adh_short; pfam00106 749927018061 NAD(P) binding site [chemical binding]; other site 749927018062 active site 749927018063 RNA polymerase factor sigma-70; Validated; Region: PRK08241 749927018064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927018065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927018066 DNA binding residues [nucleotide binding] 749927018067 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927018068 Transcription factor WhiB; Region: Whib; pfam02467 749927018069 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927018070 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927018071 DNA binding residues [nucleotide binding] 749927018072 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927018073 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927018074 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927018075 DNA binding residues [nucleotide binding] 749927018076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927018077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927018078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927018079 dimerization interface [polypeptide binding]; other site 749927018080 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 749927018081 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 749927018082 The first Cupredoxin domain of Bilirubin oxidase (BOD), the bacterial endospore coat component CotA, and similar proteins; Region: CuRO_1_BOD_CotA_like; cd13844 749927018083 dimer interface [polypeptide binding]; other site 749927018084 hexamer interface [polypeptide binding]; other site 749927018085 Domain 2 interface [polypeptide binding]; other site 749927018086 Domain 3 interface [polypeptide binding]; other site 749927018087 trinuclear Cu binding site [ion binding]; other site 749927018088 Cupredoxin superfamily; Region: Cupredoxin; cl19115 749927018089 Cupredoxin superfamily; Region: Cupredoxin; cl19115 749927018090 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927018091 Winged helix-turn helix; Region: HTH_29; pfam13551 749927018092 Homeodomain-like domain; Region: HTH_32; pfam13565 749927018093 DDE superfamily endonuclease; Region: DDE_3; pfam13358 749927018094 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927018095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927018096 NAD(P) binding site [chemical binding]; other site 749927018097 active site 749927018098 RibD C-terminal domain; Region: RibD_C; cl17279 749927018099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927018100 dimerization interface [polypeptide binding]; other site 749927018101 putative DNA binding site [nucleotide binding]; other site 749927018102 putative Zn2+ binding site [ion binding]; other site 749927018103 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 749927018104 putative hydrophobic ligand binding site [chemical binding]; other site 749927018105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927018106 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 749927018107 DNA binding site [nucleotide binding] 749927018108 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927018109 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 749927018110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927018111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927018112 binding surface 749927018113 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927018114 TPR motif; other site 749927018115 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927018116 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 749927018117 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 749927018118 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927018119 dimerization interface [polypeptide binding]; other site 749927018120 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927018121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927018122 catalytic residue [active] 749927018123 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927018124 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927018125 haloalkane dehalogenase; Provisional; Region: PRK03592 749927018126 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927018127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927018128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018129 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 749927018130 Di-iron ligands [ion binding]; other site 749927018131 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 749927018132 Rubredoxin [Energy production and conversion]; Region: COG1773 749927018133 iron binding site [ion binding]; other site 749927018134 Nitrate and nitrite sensing; Region: NIT; pfam08376 749927018135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927018136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927018137 ATP binding site [chemical binding]; other site 749927018138 Mg2+ binding site [ion binding]; other site 749927018139 G-X-G motif; other site 749927018140 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 749927018141 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927018142 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 749927018143 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 749927018144 G1 box; other site 749927018145 GTP/Mg2+ binding site [chemical binding]; other site 749927018146 G2 box; other site 749927018147 Switch I region; other site 749927018148 G3 box; other site 749927018149 Switch II region; other site 749927018150 G4 box; other site 749927018151 G5 box; other site 749927018152 ABBA-type aromatic prenyltransferases (PTases); Region: ABBA-PTs; cl19121 749927018153 active site 749927018154 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 749927018155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927018156 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927018157 DNA binding residues [nucleotide binding] 749927018158 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927018159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927018160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018161 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927018162 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 749927018163 Cupin domain; Region: Cupin_2; cl17218 749927018164 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 749927018165 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 749927018166 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 749927018167 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 749927018168 inhibitor binding site; inhibition site 749927018169 active site 749927018170 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927018171 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927018172 YCII-related domain; Region: YCII; cl00999 749927018173 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927018174 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927018175 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927018176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927018177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018178 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927018179 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927018180 putative NAD(P) binding site [chemical binding]; other site 749927018181 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927018182 AAA ATPase domain; Region: AAA_16; pfam13191 749927018183 Caspase domain; Region: Peptidase_C14; pfam00656 749927018184 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 749927018185 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 749927018186 nucleotide binding site [chemical binding]; other site 749927018187 putative NEF/HSP70 interaction site [polypeptide binding]; other site 749927018188 SBD interface [polypeptide binding]; other site 749927018189 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 749927018190 active site 749927018191 catalytic residues [active] 749927018192 DNA binding site [nucleotide binding] 749927018193 Int/Topo IB signature motif; other site 749927018194 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 749927018195 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927018196 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927018197 active site 749927018198 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927018199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018200 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 749927018201 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 749927018202 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927018203 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927018204 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927018205 putative sugar binding sites [chemical binding]; other site 749927018206 Q-X-W motif; other site 749927018207 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 749927018208 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927018209 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927018210 putative sugar binding sites [chemical binding]; other site 749927018211 Q-X-W motif; other site 749927018212 DEAD-like helicases superfamily; Region: DEXDc; smart00487 749927018213 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927018214 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 749927018215 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927018216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927018217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927018218 DNA binding residues [nucleotide binding] 749927018219 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927018220 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927018221 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927018222 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 749927018223 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 749927018224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927018225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018226 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927018227 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927018228 DNA binding residues [nucleotide binding] 749927018229 dimerization interface [polypeptide binding]; other site 749927018230 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 749927018231 polypeptide substrate binding site [polypeptide binding]; other site 749927018232 active site 749927018233 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927018234 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 749927018235 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 749927018236 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927018237 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 749927018238 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749927018239 active site 749927018240 catalytic triad [active] 749927018241 oxyanion hole [active] 749927018242 Phosphotransferase enzyme family; Region: APH; pfam01636 749927018243 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 749927018244 active site 749927018245 ATP binding site [chemical binding]; other site 749927018246 substrate binding site [chemical binding]; other site 749927018247 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 749927018248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018249 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927018250 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927018251 active site 749927018252 TDP-binding site; other site 749927018253 acceptor substrate-binding pocket; other site 749927018254 homodimer interface [polypeptide binding]; other site 749927018255 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927018256 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927018257 DNA binding site [nucleotide binding] 749927018258 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927018259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927018260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927018261 TPR motif; other site 749927018262 binding surface 749927018263 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927018264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927018265 binding surface 749927018266 TPR motif; other site 749927018267 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927018268 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927018269 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927018270 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927018271 active site 749927018272 catalytic tetrad [active] 749927018273 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927018274 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 749927018275 AAA ATPase domain; Region: AAA_16; pfam13191 749927018276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927018277 DNA binding residues [nucleotide binding] 749927018278 dimerization interface [polypeptide binding]; other site 749927018279 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 749927018280 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 749927018281 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 749927018282 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 749927018283 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 749927018284 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 749927018285 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 749927018286 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 749927018287 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 749927018288 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927018289 DNA binding residues [nucleotide binding] 749927018290 dimerization interface [polypeptide binding]; other site 749927018291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927018292 acyl-coenzyme A oxidase; Region: PLN02526 749927018293 active site 749927018294 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 749927018295 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 749927018296 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 749927018297 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927018298 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 749927018299 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 749927018300 acyl-activating enzyme (AAE) consensus motif; other site 749927018301 putative AMP binding site [chemical binding]; other site 749927018302 putative active site [active] 749927018303 putative CoA binding site [chemical binding]; other site 749927018304 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927018305 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927018306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927018307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018308 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927018309 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927018310 Probable pheophorbidase; Region: PLN02965; cl17657 749927018311 AAA ATPase domain; Region: AAA_16; pfam13191 749927018312 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927018313 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927018314 DNA binding residues [nucleotide binding] 749927018315 dimerization interface [polypeptide binding]; other site 749927018316 AAA ATPase domain; Region: AAA_16; pfam13191 749927018317 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927018318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927018319 DNA binding residues [nucleotide binding] 749927018320 dimerization interface [polypeptide binding]; other site 749927018321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927018322 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927018323 putative substrate translocation pore; other site 749927018324 Predicted acyl esterases [General function prediction only]; Region: COG2936 749927018325 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 749927018326 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 749927018327 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 749927018328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927018329 metabolite-proton symporter; Region: 2A0106; TIGR00883 749927018330 putative substrate translocation pore; other site 749927018331 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 749927018332 putative ligand binding site [chemical binding]; other site 749927018333 putative catalytic site [active] 749927018334 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 749927018335 sugar binding site [chemical binding]; other site 749927018336 Muconolactone delta-isomerase; Region: MIase; cl01992 749927018337 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927018338 anti sigma factor interaction site; other site 749927018339 regulatory phosphorylation site [posttranslational modification]; other site 749927018340 STAS domain; Region: STAS_2; pfam13466 749927018341 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 749927018342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 749927018343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927018344 ATP binding site [chemical binding]; other site 749927018345 Mg2+ binding site [ion binding]; other site 749927018346 G-X-G motif; other site 749927018347 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 749927018348 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 749927018349 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927018350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927018351 Walker A/P-loop; other site 749927018352 ATP binding site [chemical binding]; other site 749927018353 Q-loop/lid; other site 749927018354 ABC transporter signature motif; other site 749927018355 Walker B; other site 749927018356 D-loop; other site 749927018357 H-loop/switch region; other site 749927018358 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927018359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927018360 Histidine kinase; Region: HisKA_3; pfam07730 749927018361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927018362 ATP binding site [chemical binding]; other site 749927018363 Mg2+ binding site [ion binding]; other site 749927018364 G-X-G motif; other site 749927018365 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927018366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927018367 active site 749927018368 phosphorylation site [posttranslational modification] 749927018369 intermolecular recognition site; other site 749927018370 dimerization interface [polypeptide binding]; other site 749927018371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927018372 DNA binding residues [nucleotide binding] 749927018373 dimerization interface [polypeptide binding]; other site 749927018374 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 749927018375 ZIP Zinc transporter; Region: Zip; cl00437 749927018376 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 749927018377 Penicillinase repressor; Region: Penicillinase_R; pfam03965 749927018378 Peptidase family M48; Region: Peptidase_M48; cl12018 749927018379 Sulfatase; Region: Sulfatase; cl19157 749927018380 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927018381 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 749927018382 Walker A/P-loop; other site 749927018383 ATP binding site [chemical binding]; other site 749927018384 Q-loop/lid; other site 749927018385 ABC transporter signature motif; other site 749927018386 Walker B; other site 749927018387 D-loop; other site 749927018388 H-loop/switch region; other site 749927018389 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927018390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927018391 Histidine kinase; Region: HisKA_3; pfam07730 749927018392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927018393 ATP binding site [chemical binding]; other site 749927018394 Mg2+ binding site [ion binding]; other site 749927018395 G-X-G motif; other site 749927018396 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927018397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927018398 active site 749927018399 phosphorylation site [posttranslational modification] 749927018400 intermolecular recognition site; other site 749927018401 dimerization interface [polypeptide binding]; other site 749927018402 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927018403 DNA binding residues [nucleotide binding] 749927018404 dimerization interface [polypeptide binding]; other site 749927018405 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 749927018406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927018407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018408 Phage portal protein; Region: Phage_portal; cl19194 749927018409 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927018410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927018411 NAD(P) binding site [chemical binding]; other site 749927018412 active site 749927018413 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 749927018414 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927018415 NADP binding site [chemical binding]; other site 749927018416 Cupin domain; Region: Cupin_2; cl17218 749927018417 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 749927018418 DJ-1 family protein; Region: not_thiJ; TIGR01383 749927018419 conserved cys residue [active] 749927018420 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927018421 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927018422 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927018423 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927018424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927018425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927018426 putative substrate translocation pore; other site 749927018427 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 749927018428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927018429 NAD(P) binding site [chemical binding]; other site 749927018430 active site 749927018431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927018432 NAD(P) binding site [chemical binding]; other site 749927018433 active site 749927018434 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 749927018435 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927018436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927018437 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927018438 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 749927018439 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 749927018440 conserved cys residue [active] 749927018441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927018442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927018443 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 749927018444 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 749927018445 Zn2+ binding site [ion binding]; other site 749927018446 Mg2+ binding site [ion binding]; other site 749927018447 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 749927018448 homotrimer interaction site [polypeptide binding]; other site 749927018449 putative active site [active] 749927018450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927018451 GAF domain; Region: GAF_2; pfam13185 749927018452 ANTAR domain; Region: ANTAR; pfam03861 749927018453 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 749927018454 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749927018455 metal-binding site [ion binding] 749927018456 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 749927018457 Soluble P-type ATPase [General function prediction only]; Region: COG4087 749927018458 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749927018459 metal-binding site [ion binding] 749927018460 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 749927018461 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927018462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927018463 DNA binding residues [nucleotide binding] 749927018464 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 749927018465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927018466 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927018467 DNA binding residues [nucleotide binding] 749927018468 Predicted integral membrane protein [Function unknown]; Region: COG5660 749927018469 Putative zinc-finger; Region: zf-HC2; pfam13490 749927018470 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 749927018471 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 749927018472 DJ-1 family protein; Region: not_thiJ; TIGR01383 749927018473 conserved cys residue [active] 749927018474 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 749927018475 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 749927018476 Walker A/P-loop; other site 749927018477 ATP binding site [chemical binding]; other site 749927018478 Q-loop/lid; other site 749927018479 ABC transporter signature motif; other site 749927018480 Walker B; other site 749927018481 D-loop; other site 749927018482 H-loop/switch region; other site 749927018483 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 749927018484 ABC-ATPase subunit interface; other site 749927018485 dimer interface [polypeptide binding]; other site 749927018486 putative PBP binding regions; other site 749927018487 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 749927018488 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 749927018489 intersubunit interface [polypeptide binding]; other site 749927018490 CopC domain; Region: CopC; pfam04234 749927018491 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 749927018492 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749927018493 metal-binding site [ion binding] 749927018494 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 749927018495 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 749927018496 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 749927018497 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 749927018498 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 749927018499 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 749927018500 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927018501 anti sigma factor interaction site; other site 749927018502 regulatory phosphorylation site [posttranslational modification]; other site 749927018503 GAF domain; Region: GAF_2; pfam13185 749927018504 ANTAR domain; Region: ANTAR; pfam03861 749927018505 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 749927018506 GAF domain; Region: GAF; pfam01590 749927018507 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 749927018508 ANTAR domain; Region: ANTAR; pfam03861 749927018509 GAF domain; Region: GAF; pfam01590 749927018510 ANTAR domain; Region: ANTAR; pfam03861 749927018511 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 749927018512 GAF domain; Region: GAF_2; pfam13185 749927018513 ANTAR domain; Region: ANTAR; pfam03861 749927018514 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927018515 OsmC-like protein; Region: OsmC; cl00767 749927018516 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749927018517 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 749927018518 molybdopterin cofactor binding site; other site 749927018519 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 749927018520 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 749927018521 NAD binding site [chemical binding]; other site 749927018522 catalytic Zn binding site [ion binding]; other site 749927018523 structural Zn binding site [ion binding]; other site 749927018524 GAF domain; Region: GAF_2; pfam13185 749927018525 ANTAR domain; Region: ANTAR; pfam03861 749927018526 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927018527 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927018528 NAD(P) binding site [chemical binding]; other site 749927018529 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 749927018530 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 749927018531 Major royal jelly protein; Region: MRJP; pfam03022 749927018532 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927018533 NAD(P) binding site [chemical binding]; other site 749927018534 catalytic residues [active] 749927018535 Predicted membrane protein [Function unknown]; Region: COG4129 749927018536 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 749927018537 thiamine pyrophosphate protein; Provisional; Region: PRK08273 749927018538 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 749927018539 PYR/PP interface [polypeptide binding]; other site 749927018540 dimer interface [polypeptide binding]; other site 749927018541 tetramer interface [polypeptide binding]; other site 749927018542 TPP binding site [chemical binding]; other site 749927018543 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927018544 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 749927018545 TPP-binding site [chemical binding]; other site 749927018546 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 749927018547 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 749927018548 putative active site pocket [active] 749927018549 putative metal binding site [ion binding]; other site 749927018550 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927018551 FAD binding domain; Region: FAD_binding_4; pfam01565 749927018552 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 749927018553 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 749927018554 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 749927018555 ChaB; Region: ChaB; pfam06150 749927018556 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 749927018557 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 749927018558 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 749927018559 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 749927018560 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 749927018561 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 749927018562 XFP N-terminal domain; Region: XFP_N; pfam09364 749927018563 putative phosphoketolase; Provisional; Region: PRK05261 749927018564 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 749927018565 XFP C-terminal domain; Region: XFP_C; pfam09363 749927018566 Hemerythrin family; Region: Hemerythrin-like; cl15774 749927018567 Fe binding site [ion binding]; other site 749927018568 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 749927018569 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 749927018570 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927018571 NAD binding site [chemical binding]; other site 749927018572 catalytic Zn binding site [ion binding]; other site 749927018573 structural Zn binding site [ion binding]; other site 749927018574 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 749927018575 Citrate transporter; Region: CitMHS; pfam03600 749927018576 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 749927018577 transmembrane helices; other site 749927018578 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927018579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927018580 Walker A/P-loop; other site 749927018581 ATP binding site [chemical binding]; other site 749927018582 Q-loop/lid; other site 749927018583 ABC transporter signature motif; other site 749927018584 Walker B; other site 749927018585 D-loop; other site 749927018586 H-loop/switch region; other site 749927018587 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927018588 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 749927018589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927018590 S-adenosylmethionine binding site [chemical binding]; other site 749927018591 DNA primase; Validated; Region: dnaG; PRK05667 749927018592 CHC2 zinc finger; Region: zf-CHC2; pfam01807 749927018593 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 749927018594 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 749927018595 active site 749927018596 metal binding site [ion binding]; metal-binding site 749927018597 interdomain interaction site; other site 749927018598 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 749927018599 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 749927018600 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 749927018601 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927018602 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927018603 DNA binding residues [nucleotide binding] 749927018604 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927018605 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927018606 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927018607 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 749927018608 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 749927018609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927018610 putative substrate translocation pore; other site 749927018611 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927018612 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927018613 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927018614 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927018615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927018616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018617 Protein of unknown function (DUF664); Region: DUF664; pfam04978 749927018618 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 749927018619 reactive center loop; other site 749927018620 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 749927018621 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 749927018622 Zn2+ binding site [ion binding]; other site 749927018623 Mg2+ binding site [ion binding]; other site 749927018624 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 749927018625 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 749927018626 putative active site [active] 749927018627 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927018628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927018629 active site 749927018630 phosphorylation site [posttranslational modification] 749927018631 intermolecular recognition site; other site 749927018632 dimerization interface [polypeptide binding]; other site 749927018633 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927018634 DNA binding residues [nucleotide binding] 749927018635 dimerization interface [polypeptide binding]; other site 749927018636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927018637 Histidine kinase; Region: HisKA_3; pfam07730 749927018638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927018639 ATP binding site [chemical binding]; other site 749927018640 Mg2+ binding site [ion binding]; other site 749927018641 G-X-G motif; other site 749927018642 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927018643 ABC-2 type transporter; Region: ABC2_membrane; cl17235 749927018644 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927018645 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927018646 Walker A/P-loop; other site 749927018647 ATP binding site [chemical binding]; other site 749927018648 Q-loop/lid; other site 749927018649 ABC transporter signature motif; other site 749927018650 Walker B; other site 749927018651 D-loop; other site 749927018652 H-loop/switch region; other site 749927018653 glycyl-tRNA synthetase; Provisional; Region: PRK04173 749927018654 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 749927018655 dimer interface [polypeptide binding]; other site 749927018656 motif 1; other site 749927018657 active site 749927018658 motif 2; other site 749927018659 motif 3; other site 749927018660 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 749927018661 anticodon binding site; other site 749927018662 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 749927018663 active site 749927018664 putative catalytic site [active] 749927018665 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 749927018666 active site 749927018667 putative catalytic site [active] 749927018668 Predicted solute binding protein [General function prediction only]; Region: COG3889 749927018669 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927018670 dimerization interface [polypeptide binding]; other site 749927018671 putative DNA binding site [nucleotide binding]; other site 749927018672 putative Zn2+ binding site [ion binding]; other site 749927018673 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 749927018674 metal binding site 2 [ion binding]; metal-binding site 749927018675 putative DNA binding helix; other site 749927018676 metal binding site 1 [ion binding]; metal-binding site 749927018677 dimer interface [polypeptide binding]; other site 749927018678 structural Zn2+ binding site [ion binding]; other site 749927018679 TIGR03943 family protein; Region: TIGR03943 749927018680 Predicted permease; Region: DUF318; cl17795 749927018681 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 749927018682 active site 749927018683 dimer interface [polypeptide binding]; other site 749927018684 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 749927018685 Recombination protein O N terminal; Region: RecO_N; pfam11967 749927018686 Recombination protein O C terminal; Region: RecO_C; pfam02565 749927018687 Interferon-induced transmembrane protein; Region: Dispanin; pfam04505 749927018688 RDD family; Region: RDD; pfam06271 749927018689 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 749927018690 Interferon-induced transmembrane protein; Region: Dispanin; pfam04505 749927018691 Interferon-induced transmembrane protein; Region: Dispanin; pfam04505 749927018692 GTPase Era; Reviewed; Region: era; PRK00089 749927018693 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 749927018694 G1 box; other site 749927018695 GTP/Mg2+ binding site [chemical binding]; other site 749927018696 Switch I region; other site 749927018697 G2 box; other site 749927018698 Switch II region; other site 749927018699 G3 box; other site 749927018700 G4 box; other site 749927018701 G5 box; other site 749927018702 KH domain; Region: KH_2; pfam07650 749927018703 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 749927018704 Domain of unknown function DUF21; Region: DUF21; pfam01595 749927018705 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 749927018706 Transporter associated domain; Region: CorC_HlyC; smart01091 749927018707 metal-binding heat shock protein; Provisional; Region: PRK00016 749927018708 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 749927018709 PhoH-like protein; Region: PhoH; pfam02562 749927018710 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 749927018711 nucleotide binding site/active site [active] 749927018712 HIT family signature motif; other site 749927018713 catalytic residue [active] 749927018714 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 749927018715 chaperone protein DnaJ; Provisional; Region: PRK14278 749927018716 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 749927018717 HSP70 interaction site [polypeptide binding]; other site 749927018718 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 749927018719 Zn binding sites [ion binding]; other site 749927018720 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 749927018721 dimer interface [polypeptide binding]; other site 749927018722 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 749927018723 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 749927018724 HrcA protein C terminal domain; Region: HrcA; pfam01628 749927018725 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 749927018726 MAEBL; Provisional; Region: PTZ00121 749927018727 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927018728 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927018729 active site 749927018730 catalytic tetrad [active] 749927018731 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 749927018732 tetrameric interface [polypeptide binding]; other site 749927018733 NAD binding site [chemical binding]; other site 749927018734 catalytic residues [active] 749927018735 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 749927018736 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 749927018737 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927018738 Subtilisin inhibitor-like; Region: SSI; cl11594 749927018739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927018740 sequence-specific DNA binding site [nucleotide binding]; other site 749927018741 salt bridge; other site 749927018742 Domain of unknown function (DUF397); Region: DUF397; pfam04149 749927018743 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 749927018744 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927018745 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927018746 dimerization interface [polypeptide binding]; other site 749927018747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927018748 dimer interface [polypeptide binding]; other site 749927018749 phosphorylation site [posttranslational modification] 749927018750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927018751 ATP binding site [chemical binding]; other site 749927018752 Mg2+ binding site [ion binding]; other site 749927018753 G-X-G motif; other site 749927018754 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927018755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927018756 active site 749927018757 phosphorylation site [posttranslational modification] 749927018758 intermolecular recognition site; other site 749927018759 dimerization interface [polypeptide binding]; other site 749927018760 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927018761 DNA binding site [nucleotide binding] 749927018762 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 749927018763 Na binding site [ion binding]; other site 749927018764 putative substrate binding site [chemical binding]; other site 749927018765 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 749927018766 active site 749927018767 catalytic triad [active] 749927018768 dimer interface [polypeptide binding]; other site 749927018769 phenylhydantoinase; Validated; Region: PRK08323 749927018770 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 749927018771 tetramer interface [polypeptide binding]; other site 749927018772 active site 749927018773 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927018774 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 749927018775 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927018776 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927018777 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927018778 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 749927018779 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 749927018780 FAD binding pocket [chemical binding]; other site 749927018781 FAD binding motif [chemical binding]; other site 749927018782 phosphate binding motif [ion binding]; other site 749927018783 NAD binding pocket [chemical binding]; other site 749927018784 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 749927018785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018786 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927018787 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927018788 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927018789 putative NAD(P) binding site [chemical binding]; other site 749927018790 coproporphyrinogen III oxidase; Validated; Region: PRK05628 749927018791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927018792 FeS/SAM binding site; other site 749927018793 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927018794 active site 749927018795 metal binding site [ion binding]; metal-binding site 749927018796 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 749927018797 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 749927018798 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 749927018799 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 749927018800 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 749927018801 Ribosomal L37ae protein family; Region: Ribosomal_L37ae; cl19284 749927018802 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 749927018803 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 749927018804 Active Sites [active] 749927018805 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 749927018806 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 749927018807 Active Sites [active] 749927018808 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 749927018809 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 749927018810 CysD dimerization site [polypeptide binding]; other site 749927018811 G1 box; other site 749927018812 putative GEF interaction site [polypeptide binding]; other site 749927018813 GTP/Mg2+ binding site [chemical binding]; other site 749927018814 Switch I region; other site 749927018815 G2 box; other site 749927018816 G3 box; other site 749927018817 Switch II region; other site 749927018818 G4 box; other site 749927018819 G5 box; other site 749927018820 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 749927018821 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 749927018822 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 749927018823 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 749927018824 putative active site [active] 749927018825 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 749927018826 active site 749927018827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927018828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927018829 ATP binding site [chemical binding]; other site 749927018830 Mg2+ binding site [ion binding]; other site 749927018831 G-X-G motif; other site 749927018832 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 749927018833 enoyl-CoA hydratase; Provisional; Region: PRK07827 749927018834 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927018835 substrate binding site [chemical binding]; other site 749927018836 oxyanion hole (OAH) forming residues; other site 749927018837 trimer interface [polypeptide binding]; other site 749927018838 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 749927018839 putative RNAase interaction site [polypeptide binding]; other site 749927018840 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 749927018841 active site 749927018842 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927018843 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927018844 NAD(P) binding site [chemical binding]; other site 749927018845 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927018846 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927018847 amino acid transporter; Region: 2A0306; TIGR00909 749927018848 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927018849 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 749927018850 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 749927018851 Nitronate monooxygenase; Region: NMO; pfam03060 749927018852 FMN binding site [chemical binding]; other site 749927018853 substrate binding site [chemical binding]; other site 749927018854 putative catalytic residue [active] 749927018855 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927018856 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927018857 putative DNA binding site [nucleotide binding]; other site 749927018858 putative Zn2+ binding site [ion binding]; other site 749927018859 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 749927018860 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 749927018861 active site 749927018862 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 749927018863 aromatic chitin/cellulose binding site residues [chemical binding]; other site 749927018864 IncA protein; Region: IncA; pfam04156 749927018865 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 749927018866 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 749927018867 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 749927018868 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 749927018869 nucleotide binding site/active site [active] 749927018870 HIT family signature motif; other site 749927018871 catalytic residue [active] 749927018872 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927018873 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 749927018874 putative active site [active] 749927018875 GTP-binding protein LepA; Provisional; Region: PRK05433 749927018876 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 749927018877 G1 box; other site 749927018878 putative GEF interaction site [polypeptide binding]; other site 749927018879 GTP/Mg2+ binding site [chemical binding]; other site 749927018880 Switch I region; other site 749927018881 G2 box; other site 749927018882 G3 box; other site 749927018883 Switch II region; other site 749927018884 G4 box; other site 749927018885 G5 box; other site 749927018886 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 749927018887 Elongation Factor G, domain II; Region: EFG_II; pfam14492 749927018888 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 749927018889 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 749927018890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927018891 S-adenosylmethionine binding site [chemical binding]; other site 749927018892 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927018893 active site 749927018894 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 749927018895 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 749927018896 EamA-like transporter family; Region: EamA; pfam00892 749927018897 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 749927018898 hypothetical protein; Reviewed; Region: PRK07914 749927018899 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 749927018900 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 749927018901 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 749927018902 homodimer interface [polypeptide binding]; other site 749927018903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927018904 catalytic residue [active] 749927018905 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 749927018906 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 749927018907 Competence protein; Region: Competence; pfam03772 749927018908 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927018909 SLBB domain; Region: SLBB; pfam10531 749927018910 comEA protein; Region: comE; TIGR01259 749927018911 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 749927018912 EDD domain protein, DegV family; Region: DegV; TIGR00762 749927018913 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749927018914 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927018915 catalytic core [active] 749927018916 Oligomerization domain; Region: Oligomerization; cl00519 749927018917 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 749927018918 active site 749927018919 (T/H)XGH motif; other site 749927018920 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 749927018921 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927018922 ATP binding site [chemical binding]; other site 749927018923 putative Mg++ binding site [ion binding]; other site 749927018924 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927018925 nucleotide binding region [chemical binding]; other site 749927018926 ATP-binding site [chemical binding]; other site 749927018927 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927018928 active site 749927018929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927018930 putative substrate translocation pore; other site 749927018931 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 749927018932 arginine-tRNA ligase; Region: PLN02286 749927018933 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 749927018934 active site 749927018935 HIGH motif; other site 749927018936 KMSK motif region; other site 749927018937 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 749927018938 tRNA binding surface [nucleotide binding]; other site 749927018939 anticodon binding site; other site 749927018940 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927018941 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 749927018942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927018943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927018944 classical (c) SDRs; Region: SDR_c; cd05233 749927018945 short chain dehydrogenase; Provisional; Region: PRK07041 749927018946 NAD(P) binding site [chemical binding]; other site 749927018947 active site 749927018948 gamma-glutamyl kinase; Provisional; Region: PRK05429 749927018949 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 749927018950 nucleotide binding site [chemical binding]; other site 749927018951 homotetrameric interface [polypeptide binding]; other site 749927018952 putative phosphate binding site [ion binding]; other site 749927018953 putative allosteric binding site; other site 749927018954 PUA domain; Region: PUA; pfam01472 749927018955 GTPase CgtA; Reviewed; Region: obgE; PRK12296 749927018956 GTP1/OBG; Region: GTP1_OBG; pfam01018 749927018957 Obg GTPase; Region: Obg; cd01898 749927018958 G1 box; other site 749927018959 GTP/Mg2+ binding site [chemical binding]; other site 749927018960 Switch I region; other site 749927018961 G2 box; other site 749927018962 G3 box; other site 749927018963 Switch II region; other site 749927018964 G4 box; other site 749927018965 G5 box; other site 749927018966 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 749927018967 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 749927018968 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 749927018969 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 749927018970 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 749927018971 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 749927018972 homodimer interface [polypeptide binding]; other site 749927018973 oligonucleotide binding site [chemical binding]; other site 749927018974 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 749927018975 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927018976 Subtilase family; Region: Peptidase_S8; pfam00082 749927018977 active site 749927018978 catalytic residues [active] 749927018979 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927018980 ABC-2 type transporter; Region: ABC2_membrane; cl17235 749927018981 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927018982 ABC-2 type transporter; Region: ABC2_membrane; cl17235 749927018983 nodulation ABC transporter NodI; Provisional; Region: PRK13537 749927018984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927018985 Walker A/P-loop; other site 749927018986 ATP binding site [chemical binding]; other site 749927018987 Q-loop/lid; other site 749927018988 ABC transporter signature motif; other site 749927018989 Walker B; other site 749927018990 D-loop; other site 749927018991 H-loop/switch region; other site 749927018992 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 749927018993 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 749927018994 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927018995 active site 749927018996 metal binding site [ion binding]; metal-binding site 749927018997 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927018998 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 749927018999 Nucleoside diphosphate kinase; Region: NDK; pfam00334 749927019000 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 749927019001 active site 749927019002 multimer interface [polypeptide binding]; other site 749927019003 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 749927019004 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 749927019005 putative active site [active] 749927019006 putative metal binding site [ion binding]; other site 749927019007 Penicillin amidase; Region: Penicil_amidase; pfam01804 749927019008 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 749927019009 active site 749927019010 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 749927019011 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 749927019012 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749927019013 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 749927019014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927019015 S-adenosylmethionine binding site [chemical binding]; other site 749927019016 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 749927019017 active site 749927019018 catalytic triad [active] 749927019019 oxyanion hole [active] 749927019020 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927019021 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927019022 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 749927019023 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927019024 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927019025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927019026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927019027 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 749927019028 substrate binding pocket [chemical binding]; other site 749927019029 dimerization interface [polypeptide binding]; other site 749927019030 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 749927019031 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 749927019032 active site 749927019033 HIGH motif; other site 749927019034 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 749927019035 KMSKS motif; other site 749927019036 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 749927019037 tRNA binding surface [nucleotide binding]; other site 749927019038 anticodon binding site; other site 749927019039 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 749927019040 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927019041 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927019042 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927019043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927019044 putative substrate translocation pore; other site 749927019045 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 749927019046 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 749927019047 putative molybdopterin cofactor binding site [chemical binding]; other site 749927019048 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 749927019049 putative molybdopterin cofactor binding site; other site 749927019050 Transcriptional regulator [Transcription]; Region: LytR; COG1316 749927019051 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 749927019052 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 749927019053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927019054 putative substrate translocation pore; other site 749927019055 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 749927019056 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 749927019057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927019058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927019059 WHG domain; Region: WHG; pfam13305 749927019060 Predicted esterase [General function prediction only]; Region: COG0627 749927019061 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 749927019062 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 749927019063 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 749927019064 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 749927019065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927019066 Walker A motif; other site 749927019067 ATP binding site [chemical binding]; other site 749927019068 Walker B motif; other site 749927019069 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 749927019070 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 749927019071 oligomer interface [polypeptide binding]; other site 749927019072 active site residues [active] 749927019073 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 749927019074 oligomer interface [polypeptide binding]; other site 749927019075 active site residues [active] 749927019076 trigger factor; Provisional; Region: tig; PRK01490 749927019077 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 749927019078 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 749927019079 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 749927019080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927019081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927019082 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 749927019083 putative di-iron ligands [ion binding]; other site 749927019084 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 749927019085 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 749927019086 FAD binding pocket [chemical binding]; other site 749927019087 FAD binding motif [chemical binding]; other site 749927019088 phosphate binding motif [ion binding]; other site 749927019089 beta-alpha-beta structure motif; other site 749927019090 NAD(p) ribose binding residues [chemical binding]; other site 749927019091 NAD binding pocket [chemical binding]; other site 749927019092 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 749927019093 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927019094 catalytic loop [active] 749927019095 iron binding site [ion binding]; other site 749927019096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927019097 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 749927019098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927019099 dimer interface [polypeptide binding]; other site 749927019100 phosphorylation site [posttranslational modification] 749927019101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927019102 ATP binding site [chemical binding]; other site 749927019103 Mg2+ binding site [ion binding]; other site 749927019104 G-X-G motif; other site 749927019105 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 749927019106 thiamine monophosphate kinase; Provisional; Region: PRK05731 749927019107 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 749927019108 ATP binding site [chemical binding]; other site 749927019109 dimerization interface [polypeptide binding]; other site 749927019110 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 749927019111 trimer interface [polypeptide binding]; other site 749927019112 active site 749927019113 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927019114 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927019115 non-specific DNA binding site [nucleotide binding]; other site 749927019116 salt bridge; other site 749927019117 sequence-specific DNA binding site [nucleotide binding]; other site 749927019118 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 749927019119 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 749927019120 ligand binding site [chemical binding]; other site 749927019121 flexible hinge region; other site 749927019122 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 749927019123 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 749927019124 Ligand binding site; other site 749927019125 Ligand binding site; other site 749927019126 Ligand binding site; other site 749927019127 Putative Catalytic site; other site 749927019128 DXD motif; other site 749927019129 GtrA-like protein; Region: GtrA; pfam04138 749927019130 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 749927019131 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 749927019132 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 749927019133 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 749927019134 DNA binding site [nucleotide binding] 749927019135 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927019136 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 749927019137 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 749927019138 potential frameshift: common BLAST hit: gi|256380249|ref|YP_003103909.1| NB-ARC domain protein 749927019139 AAA ATPase domain; Region: AAA_16; pfam13191 749927019140 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927019141 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927019142 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927019143 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927019144 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 749927019145 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 749927019146 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927019147 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 749927019148 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927019149 active site 749927019150 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 749927019151 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927019152 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927019153 Walker A/P-loop; other site 749927019154 ATP binding site [chemical binding]; other site 749927019155 Q-loop/lid; other site 749927019156 ABC transporter signature motif; other site 749927019157 Walker B; other site 749927019158 D-loop; other site 749927019159 H-loop/switch region; other site 749927019160 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 749927019161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927019162 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927019163 Subtilase family; Region: Peptidase_S8; pfam00082 749927019164 active site 749927019165 catalytic residues [active] 749927019166 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927019167 MarR family; Region: MarR_2; pfam12802 749927019168 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927019169 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927019170 nucleotide binding site [chemical binding]; other site 749927019171 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927019172 xylose isomerase; Provisional; Region: PRK12677 749927019173 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927019174 Trehalose utilisation; Region: ThuA; pfam06283 749927019175 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927019176 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927019177 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 749927019178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927019179 putative substrate translocation pore; other site 749927019180 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927019181 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927019182 active site 749927019183 catalytic tetrad [active] 749927019184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927019185 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 749927019186 Helix-turn-helix domain; Region: HTH_17; pfam12728 749927019187 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 749927019188 intracellular protease, PfpI family; Region: PfpI; TIGR01382 749927019189 proposed catalytic triad [active] 749927019190 conserved cys residue [active] 749927019191 PAS domain; Region: PAS_8; pfam13188 749927019192 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927019193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927019194 dimerization interface [polypeptide binding]; other site 749927019195 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 749927019196 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927019197 dimerization interface [polypeptide binding]; other site 749927019198 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927019199 dimerization interface [polypeptide binding]; other site 749927019200 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927019201 dimerization interface [polypeptide binding]; other site 749927019202 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 749927019203 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927019204 dimerization interface [polypeptide binding]; other site 749927019205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927019206 dimerization interface [polypeptide binding]; other site 749927019207 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927019208 dimerization interface [polypeptide binding]; other site 749927019209 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927019210 dimerization interface [polypeptide binding]; other site 749927019211 GAF domain; Region: GAF_2; pfam13185 749927019212 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 749927019213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927019214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927019215 dimer interface [polypeptide binding]; other site 749927019216 phosphorylation site [posttranslational modification] 749927019217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927019218 ATP binding site [chemical binding]; other site 749927019219 Mg2+ binding site [ion binding]; other site 749927019220 G-X-G motif; other site 749927019221 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927019222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927019223 active site 749927019224 phosphorylation site [posttranslational modification] 749927019225 intermolecular recognition site; other site 749927019226 dimerization interface [polypeptide binding]; other site 749927019227 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 749927019228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927019229 S-adenosylmethionine binding site [chemical binding]; other site 749927019230 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 749927019231 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927019232 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927019233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927019234 non-specific DNA binding site [nucleotide binding]; other site 749927019235 salt bridge; other site 749927019236 sequence-specific DNA binding site [nucleotide binding]; other site 749927019237 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 749927019238 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 749927019239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927019240 motif II; other site 749927019241 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 749927019242 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927019243 putative NAD(P) binding site [chemical binding]; other site 749927019244 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 749927019245 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 749927019246 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 749927019247 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927019248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927019249 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 749927019250 dimerization interface [polypeptide binding]; other site 749927019251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927019252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927019253 short chain dehydrogenase; Provisional; Region: PRK06500 749927019254 classical (c) SDRs; Region: SDR_c; cd05233 749927019255 NAD(P) binding site [chemical binding]; other site 749927019256 active site 749927019257 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 749927019258 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 749927019259 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927019260 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927019261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927019262 NAD(P) binding site [chemical binding]; other site 749927019263 active site 749927019264 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927019265 alpha-galactosidase; Region: PLN02808; cl17638 749927019266 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 749927019267 Ca binding site [ion binding]; other site 749927019268 Ca binding site (active) [ion binding]; other site 749927019269 ligand binding site [chemical binding]; other site 749927019270 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927019271 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927019272 AAA domain; Region: AAA_27; pfam13514 749927019273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927019274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927019275 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 749927019276 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 749927019277 ring oligomerisation interface [polypeptide binding]; other site 749927019278 ATP/Mg binding site [chemical binding]; other site 749927019279 stacking interactions; other site 749927019280 hinge regions; other site 749927019281 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 749927019282 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 749927019283 putative DNA binding site [nucleotide binding]; other site 749927019284 catalytic residue [active] 749927019285 putative H2TH interface [polypeptide binding]; other site 749927019286 putative catalytic residues [active] 749927019287 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 749927019288 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 749927019289 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 749927019290 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927019291 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749927019292 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 749927019293 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 749927019294 Zn binding site [ion binding]; other site 749927019295 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 749927019296 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; pfam04536 749927019297 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 749927019298 active site 749927019299 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 749927019300 Mechanosensitive ion channel; Region: MS_channel; pfam00924 749927019301 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 749927019302 apolar tunnel; other site 749927019303 heme binding site [chemical binding]; other site 749927019304 dimerization interface [polypeptide binding]; other site 749927019305 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 749927019306 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 749927019307 active site 749927019308 catalytic site [active] 749927019309 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 749927019310 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 749927019311 active site 749927019312 NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902 749927019313 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 749927019314 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 749927019315 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 749927019316 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749927019317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927019318 Walker A/P-loop; other site 749927019319 ATP binding site [chemical binding]; other site 749927019320 Q-loop/lid; other site 749927019321 ABC transporter signature motif; other site 749927019322 ABC transporter; Region: ABC_tran_2; pfam12848 749927019323 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749927019324 Copper resistance protein D; Region: CopD; cl00563 749927019325 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 749927019326 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927019327 catalytic core [active] 749927019328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927019329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927019330 ATP binding site [chemical binding]; other site 749927019331 Mg2+ binding site [ion binding]; other site 749927019332 G-X-G motif; other site 749927019333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927019334 putative substrate translocation pore; other site 749927019335 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927019336 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927019337 inhibitor-cofactor binding pocket; inhibition site 749927019338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927019339 catalytic residue [active] 749927019340 choline dehydrogenase; Validated; Region: PRK02106 749927019341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927019342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927019343 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 749927019344 Amino acid permease; Region: AA_permease_2; pfam13520 749927019345 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927019346 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 749927019347 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927019348 active site 749927019349 choline dehydrogenase; Validated; Region: PRK02106 749927019350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927019351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927019352 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 749927019353 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 749927019354 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 749927019355 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 749927019356 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 749927019357 dimer interface [polypeptide binding]; other site 749927019358 catalytic triad [active] 749927019359 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 749927019360 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 749927019361 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 749927019362 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 749927019363 NAD binding site [chemical binding]; other site 749927019364 catalytic residues [active] 749927019365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927019366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927019367 putative substrate translocation pore; other site 749927019368 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927019369 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927019370 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927019371 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927019372 active site 749927019373 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927019374 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927019375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927019376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927019377 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 749927019378 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 749927019379 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 749927019380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927019381 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 749927019382 NAD(P) binding site [chemical binding]; other site 749927019383 active site 749927019384 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 749927019385 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 749927019386 active site 749927019387 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 749927019388 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 749927019389 active site 749927019390 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 749927019391 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 749927019392 short chain dehydrogenase; Region: adh_short; pfam00106 749927019393 putative NADP binding site [chemical binding]; other site 749927019394 active site 749927019395 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 749927019396 TIGR03084 family protein; Region: TIGR03084 749927019397 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 749927019398 Wyosine base formation; Region: Wyosine_form; pfam08608 749927019399 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927019400 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 749927019401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927019402 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927019403 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 749927019404 Cytochrome P450; Region: p450; pfam00067 749927019405 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 749927019406 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 749927019407 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 749927019408 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 749927019409 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 749927019410 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927019411 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 749927019412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927019413 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927019414 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927019415 DNA binding site [nucleotide binding] 749927019416 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927019417 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927019418 dimerization interface [polypeptide binding]; other site 749927019419 putative DNA binding site [nucleotide binding]; other site 749927019420 putative Zn2+ binding site [ion binding]; other site 749927019421 SCP-2 sterol transfer family; Region: SCP2; cl01225 749927019422 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927019423 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927019424 YCII-related domain; Region: YCII; cl00999 749927019425 TIGR03084 family protein; Region: TIGR03084 749927019426 Wyosine base formation; Region: Wyosine_form; pfam08608 749927019427 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 749927019428 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 749927019429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927019430 Histidine kinase; Region: HisKA_3; pfam07730 749927019431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927019432 Histidine kinase; Region: HisKA_3; pfam07730 749927019433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927019434 ATP binding site [chemical binding]; other site 749927019435 Mg2+ binding site [ion binding]; other site 749927019436 G-X-G motif; other site 749927019437 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927019438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927019439 active site 749927019440 phosphorylation site [posttranslational modification] 749927019441 intermolecular recognition site; other site 749927019442 dimerization interface [polypeptide binding]; other site 749927019443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927019444 DNA binding residues [nucleotide binding] 749927019445 dimerization interface [polypeptide binding]; other site 749927019446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927019447 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 749927019448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927019449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927019450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927019451 active site 749927019452 phosphorylation site [posttranslational modification] 749927019453 intermolecular recognition site; other site 749927019454 dimerization interface [polypeptide binding]; other site 749927019455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927019456 DNA binding residues [nucleotide binding] 749927019457 dimerization interface [polypeptide binding]; other site 749927019458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927019459 Histidine kinase; Region: HisKA_3; pfam07730 749927019460 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 749927019461 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 749927019462 NADPH bind site [chemical binding]; other site 749927019463 putative FMN binding site [chemical binding]; other site 749927019464 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 749927019465 YcaO-like family; Region: YcaO; pfam02624 749927019466 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927019467 dimerization interface [polypeptide binding]; other site 749927019468 putative DNA binding site [nucleotide binding]; other site 749927019469 putative Zn2+ binding site [ion binding]; other site 749927019470 SCP-2 sterol transfer family; Region: SCP2; cl01225 749927019471 CopC domain; Region: CopC; pfam04234 749927019472 Copper resistance protein D; Region: CopD; cl00563 749927019473 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927019474 TIGR03086 family protein; Region: TIGR03086 749927019475 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 749927019476 CAAX protease self-immunity; Region: Abi; pfam02517 749927019477 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 749927019478 putative homodimer interface [polypeptide binding]; other site 749927019479 putative homotetramer interface [polypeptide binding]; other site 749927019480 putative allosteric switch controlling residues; other site 749927019481 putative metal binding site [ion binding]; other site 749927019482 putative homodimer-homodimer interface [polypeptide binding]; other site 749927019483 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 749927019484 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749927019485 metal-binding site [ion binding] 749927019486 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 749927019487 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 749927019488 metal-binding site [ion binding] 749927019489 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 749927019490 active site 749927019491 SAM binding site [chemical binding]; other site 749927019492 homodimer interface [polypeptide binding]; other site 749927019493 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 749927019494 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927019495 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927019496 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 749927019497 malonic semialdehyde reductase; Provisional; Region: PRK10538 749927019498 putative NAD(P) binding site [chemical binding]; other site 749927019499 homotetramer interface [polypeptide binding]; other site 749927019500 homodimer interface [polypeptide binding]; other site 749927019501 active site 749927019502 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 749927019503 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 749927019504 FO synthase; Reviewed; Region: fbiC; PRK09234 749927019505 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927019506 FeS/SAM binding site; other site 749927019507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927019508 FeS/SAM binding site; other site 749927019509 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 749927019510 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 749927019511 Probable molybdopterin binding domain; Region: MoCF_biosynth; smart00852 749927019512 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 749927019513 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927019514 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927019515 Methyltransferase domain; Region: Methyltransf_11; pfam08241 749927019516 Immunoglobulin domain; Region: Ig; cl11960 749927019517 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 749927019518 putative metal binding site [ion binding]; other site 749927019519 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 749927019520 Right handed beta helix region; Region: Beta_helix; pfam13229 749927019521 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927019522 sugar binding site [chemical binding]; other site 749927019523 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 749927019524 putative metal binding site [ion binding]; other site 749927019525 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 749927019526 Right handed beta helix region; Region: Beta_helix; pfam13229 749927019527 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927019528 sugar binding site [chemical binding]; other site 749927019529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927019530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927019531 active site 749927019532 phosphorylation site [posttranslational modification] 749927019533 intermolecular recognition site; other site 749927019534 dimerization interface [polypeptide binding]; other site 749927019535 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927019536 DNA binding site [nucleotide binding] 749927019537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927019538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927019539 dimerization interface [polypeptide binding]; other site 749927019540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927019541 dimer interface [polypeptide binding]; other site 749927019542 phosphorylation site [posttranslational modification] 749927019543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927019544 ATP binding site [chemical binding]; other site 749927019545 Mg2+ binding site [ion binding]; other site 749927019546 G-X-G motif; other site 749927019547 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 749927019548 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927019549 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927019550 DNA binding site [nucleotide binding] 749927019551 domain linker motif; other site 749927019552 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 749927019553 putative dimerization interface [polypeptide binding]; other site 749927019554 putative ligand binding site [chemical binding]; other site 749927019555 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927019556 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927019557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927019558 dimer interface [polypeptide binding]; other site 749927019559 conserved gate region; other site 749927019560 putative PBP binding loops; other site 749927019561 ABC-ATPase subunit interface; other site 749927019562 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927019563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927019564 dimer interface [polypeptide binding]; other site 749927019565 conserved gate region; other site 749927019566 putative PBP binding loops; other site 749927019567 ABC-ATPase subunit interface; other site 749927019568 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 749927019569 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 749927019570 active site 749927019571 catalytic site [active] 749927019572 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 749927019573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927019574 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 749927019575 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927019576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927019577 TPR motif; other site 749927019578 binding surface 749927019579 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 749927019580 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 749927019581 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 749927019582 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 749927019583 Ligand Binding Site [chemical binding]; other site 749927019584 Molecular Tunnel; other site 749927019585 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 749927019586 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927019587 putative DNA binding site [nucleotide binding]; other site 749927019588 dimerization interface [polypeptide binding]; other site 749927019589 putative Zn2+ binding site [ion binding]; other site 749927019590 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927019591 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927019592 Uncharacterized conserved protein [Function unknown]; Region: COG5276 749927019593 Uncharacterized conserved protein [Function unknown]; Region: COG5276 749927019594 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 749927019595 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 749927019596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927019597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927019598 LysR substrate binding domain; Region: LysR_substrate; pfam03466 749927019599 dimerization interface [polypeptide binding]; other site 749927019600 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927019601 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 749927019602 NAD(P) binding site [chemical binding]; other site 749927019603 active site 749927019604 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 749927019605 classical (c) SDRs; Region: SDR_c; cd05233 749927019606 NAD(P) binding site [chemical binding]; other site 749927019607 active site 749927019608 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 749927019609 putative active site [active] 749927019610 putative catalytic triad [active] 749927019611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927019612 Coenzyme A binding pocket [chemical binding]; other site 749927019613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927019614 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 749927019615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927019616 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 749927019617 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 749927019618 putative acyl-acceptor binding pocket; other site 749927019619 Domain of unknown function (DUF385); Region: DUF385; pfam04075 749927019620 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927019621 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927019622 DNA binding site [nucleotide binding] 749927019623 domain linker motif; other site 749927019624 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927019625 dimerization interface [polypeptide binding]; other site 749927019626 ligand binding site [chemical binding]; other site 749927019627 Protein of unknown function (DUF993); Region: DUF993; pfam06187 749927019628 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927019629 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 749927019630 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927019631 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 749927019632 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927019633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927019634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927019635 active site 749927019636 intermolecular recognition site; other site 749927019637 dimerization interface [polypeptide binding]; other site 749927019638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927019639 DNA binding site [nucleotide binding] 749927019640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927019641 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927019642 dimerization interface [polypeptide binding]; other site 749927019643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927019644 dimer interface [polypeptide binding]; other site 749927019645 phosphorylation site [posttranslational modification] 749927019646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927019647 ATP binding site [chemical binding]; other site 749927019648 Mg2+ binding site [ion binding]; other site 749927019649 G-X-G motif; other site 749927019650 amino acid transporter; Region: 2A0306; TIGR00909 749927019651 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927019652 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 749927019653 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 749927019654 putative active site [active] 749927019655 catalytic triad [active] 749927019656 putative dimer interface [polypeptide binding]; other site 749927019657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927019658 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 749927019659 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 749927019660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927019661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927019662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927019663 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 749927019664 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 749927019665 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927019666 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927019667 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 749927019668 active site 749927019669 catalytic triad [active] 749927019670 oxyanion hole [active] 749927019671 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 749927019672 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927019673 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927019674 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 749927019675 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 749927019676 active site 749927019677 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927019678 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927019679 acyl-activating enzyme (AAE) consensus motif; other site 749927019680 AMP binding site [chemical binding]; other site 749927019681 active site 749927019682 CoA binding site [chemical binding]; other site 749927019683 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 749927019684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927019685 dimerization interface [polypeptide binding]; other site 749927019686 putative DNA binding site [nucleotide binding]; other site 749927019687 putative Zn2+ binding site [ion binding]; other site 749927019688 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927019689 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927019690 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 749927019691 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 749927019692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927019693 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 749927019694 dimerization interface [polypeptide binding]; other site 749927019695 substrate binding pocket [chemical binding]; other site 749927019696 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 749927019697 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 749927019698 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 749927019699 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 749927019700 NAD binding site [chemical binding]; other site 749927019701 Phe binding site; other site 749927019702 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927019703 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 749927019704 PaaX-like protein; Region: PaaX; pfam07848 749927019705 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 749927019706 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 749927019707 Creatinine amidohydrolase; Region: Creatininase; pfam02633 749927019708 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927019709 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 749927019710 acyl-activating enzyme (AAE) consensus motif; other site 749927019711 AMP binding site [chemical binding]; other site 749927019712 active site 749927019713 CoA binding site [chemical binding]; other site 749927019714 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927019715 classical (c) SDRs; Region: SDR_c; cd05233 749927019716 NAD(P) binding site [chemical binding]; other site 749927019717 active site 749927019718 enoyl-CoA hydratase; Provisional; Region: PRK08258 749927019719 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927019720 substrate binding site [chemical binding]; other site 749927019721 oxyanion hole (OAH) forming residues; other site 749927019722 trimer interface [polypeptide binding]; other site 749927019723 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 749927019724 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 749927019725 active site 749927019726 AAA domain; Region: AAA_22; pfam13401 749927019727 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927019728 active site 749927019729 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 749927019730 Strictosidine synthase; Region: Str_synth; cl19733 749927019731 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927019732 catalytic core [active] 749927019733 Phosphotransferase enzyme family; Region: APH; pfam01636 749927019734 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 749927019735 putative active site [active] 749927019736 putative substrate binding site [chemical binding]; other site 749927019737 ATP binding site [chemical binding]; other site 749927019738 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 749927019739 short chain dehydrogenase; Provisional; Region: PRK08251 749927019740 NAD(P) binding site [chemical binding]; other site 749927019741 active site 749927019742 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 749927019743 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 749927019744 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 749927019745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927019746 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 749927019747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927019748 DNA binding residues [nucleotide binding] 749927019749 dimerization interface [polypeptide binding]; other site 749927019750 Domain of unknown function (DUF4440); Region: DUF4440; pfam14534 749927019751 acyl-CoA synthetase; Validated; Region: PRK07788 749927019752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927019753 acyl-activating enzyme (AAE) consensus motif; other site 749927019754 AMP binding site [chemical binding]; other site 749927019755 active site 749927019756 CoA binding site [chemical binding]; other site 749927019757 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 749927019758 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 749927019759 active site 749927019760 DNA binding site [nucleotide binding] 749927019761 catalytic site [active] 749927019762 BNR repeat-like domain; Region: BNR_2; pfam13088 749927019763 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 749927019764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927019765 ATP binding site [chemical binding]; other site 749927019766 putative Mg++ binding site [ion binding]; other site 749927019767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927019768 nucleotide binding region [chemical binding]; other site 749927019769 ATP-binding site [chemical binding]; other site 749927019770 Helicase associated domain (HA2); Region: HA2; pfam04408 749927019771 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 749927019772 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 749927019773 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 749927019774 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 749927019775 putative active site [active] 749927019776 putative substrate binding site [chemical binding]; other site 749927019777 putative FMN binding site [chemical binding]; other site 749927019778 putative catalytic residues [active] 749927019779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927019780 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 749927019781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927019782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927019783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927019784 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927019785 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 749927019786 chitosan binding site [chemical binding]; other site 749927019787 catalytic residues [active] 749927019788 hypothetical protein; Provisional; Region: PRK07945 749927019789 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 749927019790 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 749927019791 active site 749927019792 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927019793 active site 749927019794 metal binding site [ion binding]; metal-binding site 749927019795 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927019796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927019797 DNA-binding site [nucleotide binding]; DNA binding site 749927019798 FCD domain; Region: FCD; pfam07729 749927019799 dihydroxy-acid dehydratase; Validated; Region: PRK06131 749927019800 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 749927019801 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 749927019802 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 749927019803 VanW like protein; Region: VanW; pfam04294 749927019804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927019805 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927019806 putative substrate translocation pore; other site 749927019807 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927019808 metal binding site [ion binding]; metal-binding site 749927019809 active site 749927019810 I-site; other site 749927019811 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 749927019812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927019813 catalytic residue [active] 749927019814 Dienelactone hydrolase family; Region: DLH; pfam01738 749927019815 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927019816 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927019817 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927019818 DNA binding residues [nucleotide binding] 749927019819 YCII-related domain; Region: YCII; cl00999 749927019820 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 749927019821 rRNA binding site [nucleotide binding]; other site 749927019822 predicted 30S ribosome binding site; other site 749927019823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927019824 Coenzyme A binding pocket [chemical binding]; other site 749927019825 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927019826 active site 749927019827 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927019828 active site 749927019829 metal binding site [ion binding]; metal-binding site 749927019830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927019831 DNA-binding site [nucleotide binding]; DNA binding site 749927019832 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 749927019833 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927019834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927019835 homodimer interface [polypeptide binding]; other site 749927019836 catalytic residue [active] 749927019837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927019838 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927019839 putative substrate translocation pore; other site 749927019840 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 749927019841 H2TH interface [polypeptide binding]; other site 749927019842 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 749927019843 DNA binding site [nucleotide binding] 749927019844 putative catalytic residues [active] 749927019845 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 749927019846 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 749927019847 Initiation factor 2 subunit family; Region: IF-2B; cl00348 749927019848 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927019849 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927019850 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927019851 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 749927019852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927019853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927019854 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927019855 FAD binding domain; Region: FAD_binding_4; pfam01565 749927019856 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 749927019857 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 749927019858 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 749927019859 GAF domain; Region: GAF; pfam01590 749927019860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927019861 Histidine kinase; Region: HisKA_3; pfam07730 749927019862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927019863 ATP binding site [chemical binding]; other site 749927019864 Mg2+ binding site [ion binding]; other site 749927019865 G-X-G motif; other site 749927019866 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927019867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927019868 active site 749927019869 phosphorylation site [posttranslational modification] 749927019870 intermolecular recognition site; other site 749927019871 dimerization interface [polypeptide binding]; other site 749927019872 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927019873 DNA binding residues [nucleotide binding] 749927019874 dimerization interface [polypeptide binding]; other site 749927019875 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 749927019876 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 749927019877 active site 749927019878 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 749927019879 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 749927019880 Walker A/P-loop; other site 749927019881 ATP binding site [chemical binding]; other site 749927019882 Q-loop/lid; other site 749927019883 ABC transporter signature motif; other site 749927019884 Walker B; other site 749927019885 D-loop; other site 749927019886 H-loop/switch region; other site 749927019887 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 749927019888 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 749927019889 Walker A/P-loop; other site 749927019890 ATP binding site [chemical binding]; other site 749927019891 Q-loop/lid; other site 749927019892 ABC transporter signature motif; other site 749927019893 Walker B; other site 749927019894 D-loop; other site 749927019895 H-loop/switch region; other site 749927019896 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 749927019897 TM-ABC transporter signature motif; other site 749927019898 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 749927019899 TM-ABC transporter signature motif; other site 749927019900 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 749927019901 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927019902 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927019903 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927019904 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 749927019905 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 749927019906 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927019907 sugar binding site [chemical binding]; other site 749927019908 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 749927019909 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 749927019910 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 749927019911 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 749927019912 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 749927019913 active site 749927019914 dimer interface [polypeptide binding]; other site 749927019915 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 749927019916 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 749927019917 active site 749927019918 FMN binding site [chemical binding]; other site 749927019919 substrate binding site [chemical binding]; other site 749927019920 3Fe-4S cluster binding site [ion binding]; other site 749927019921 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 749927019922 domain interface; other site 749927019923 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 749927019924 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 749927019925 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927019926 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 749927019927 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927019928 putative NAD(P) binding site [chemical binding]; other site 749927019929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927019930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927019931 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 749927019932 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927019933 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927019934 nucleotide binding site [chemical binding]; other site 749927019935 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 749927019936 cobyric acid synthase; Provisional; Region: PRK00784 749927019937 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927019938 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 749927019939 catalytic triad [active] 749927019940 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 749927019941 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 749927019942 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 749927019943 putative dimer interface [polypeptide binding]; other site 749927019944 active site pocket [active] 749927019945 putative cataytic base [active] 749927019946 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 749927019947 Predicted transcriptional regulator [Transcription]; Region: COG2378 749927019948 HTH domain; Region: HTH_11; pfam08279 749927019949 WYL domain; Region: WYL; pfam13280 749927019950 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 749927019951 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 749927019952 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927019953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927019954 homodimer interface [polypeptide binding]; other site 749927019955 catalytic residue [active] 749927019956 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 749927019957 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927019958 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 749927019959 catalytic triad [active] 749927019960 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 749927019961 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 749927019962 homodimer interface [polypeptide binding]; other site 749927019963 Walker A motif; other site 749927019964 ATP binding site [chemical binding]; other site 749927019965 hydroxycobalamin binding site [chemical binding]; other site 749927019966 Walker B motif; other site 749927019967 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 749927019968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927019969 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 749927019970 metal ion-dependent adhesion site (MIDAS); other site 749927019971 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 749927019972 active site 749927019973 putative homodimer interface [polypeptide binding]; other site 749927019974 SAM binding site [chemical binding]; other site 749927019975 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 749927019976 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 749927019977 active site 749927019978 SAM binding site [chemical binding]; other site 749927019979 homodimer interface [polypeptide binding]; other site 749927019980 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927019981 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927019982 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927019983 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 749927019984 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 749927019985 putative FMN binding site [chemical binding]; other site 749927019986 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 749927019987 EmbC C-terminal domain; Region: Arabino_trans_C; pfam14896 749927019988 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 749927019989 active site 749927019990 SAM binding site [chemical binding]; other site 749927019991 homodimer interface [polypeptide binding]; other site 749927019992 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 749927019993 active site 749927019994 SAM binding site [chemical binding]; other site 749927019995 homodimer interface [polypeptide binding]; other site 749927019996 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 749927019997 precorrin-3B synthase; Region: CobG; TIGR02435 749927019998 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 749927019999 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 749927020000 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 749927020001 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927020002 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927020003 Walker A/P-loop; other site 749927020004 ATP binding site [chemical binding]; other site 749927020005 Q-loop/lid; other site 749927020006 ABC transporter signature motif; other site 749927020007 Walker B; other site 749927020008 D-loop; other site 749927020009 H-loop/switch region; other site 749927020010 ABC-2 type transporter; Region: ABC2_membrane; cl17235 749927020011 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 749927020012 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927020013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927020014 non-specific DNA binding site [nucleotide binding]; other site 749927020015 salt bridge; other site 749927020016 sequence-specific DNA binding site [nucleotide binding]; other site 749927020017 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 749927020018 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 749927020019 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 749927020020 active site 749927020021 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 749927020022 aromatic chitin/cellulose binding site residues [chemical binding]; other site 749927020023 RibD C-terminal domain; Region: RibD_C; cl17279 749927020024 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 749927020025 catalytic motif [active] 749927020026 Zn binding site [ion binding]; other site 749927020027 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927020028 NAD(P) binding site [chemical binding]; other site 749927020029 catalytic residues [active] 749927020030 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 749927020031 DDE superfamily endonuclease; Region: DDE_5; pfam13546 749927020032 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 749927020033 HhH-GPD superfamily base excision DNA repair protein; Region: HhH-GPD; pfam00730 749927020034 minor groove reading motif; other site 749927020035 helix-hairpin-helix signature motif; other site 749927020036 active site 749927020037 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 749927020038 amidohydrolase; Region: amidohydrolases; TIGR01891 749927020039 metal binding site [ion binding]; metal-binding site 749927020040 Trypsin; Region: Trypsin; pfam00089 749927020041 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927020042 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 749927020043 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 749927020044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927020045 Walker A motif; other site 749927020046 ATP binding site [chemical binding]; other site 749927020047 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 749927020048 putative active site [active] 749927020049 putative substrate binding site [chemical binding]; other site 749927020050 dimer interface [polypeptide binding]; other site 749927020051 catalytic site [active] 749927020052 metabolite-proton symporter; Region: 2A0106; TIGR00883 749927020053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927020054 putative substrate translocation pore; other site 749927020055 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 749927020056 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 749927020057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 749927020058 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 749927020059 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 749927020060 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 749927020061 Int/Topo IB signature motif; other site 749927020062 Helix-turn-helix domain; Region: HTH_17; pfam12728 749927020063 DNA methylase; Region: N6_N4_Mtase; pfam01555 749927020064 DNA methylase; Region: N6_N4_Mtase; cl17433 749927020065 Bacterial transcriptional activator domain; Region: BTAD; smart01043 749927020066 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 749927020067 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 749927020068 Walker A motif; other site 749927020069 ATP binding site [chemical binding]; other site 749927020070 Walker B motif; other site 749927020071 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 749927020072 hypothetical protein; Provisional; Region: PRK06847 749927020073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927020074 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927020075 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927020076 Domain of unknown function (DUF397); Region: DUF397; pfam04149 749927020077 Helix-turn-helix domain; Region: HTH_31; pfam13560 749927020078 Homeodomain-like domain; Region: HTH_23; pfam13384 749927020079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927020080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927020081 non-specific DNA binding site [nucleotide binding]; other site 749927020082 salt bridge; other site 749927020083 sequence-specific DNA binding site [nucleotide binding]; other site 749927020084 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927020085 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927020086 non-specific DNA binding site [nucleotide binding]; other site 749927020087 salt bridge; other site 749927020088 sequence-specific DNA binding site [nucleotide binding]; other site 749927020089 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 749927020090 nudix motif; other site 749927020091 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 749927020092 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927020093 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927020094 active site 749927020095 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927020096 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 749927020097 putative NAD(P) binding site [chemical binding]; other site 749927020098 catalytic Zn binding site [ion binding]; other site 749927020099 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 749927020100 tetramer interface [polypeptide binding]; other site 749927020101 TPP-binding site [chemical binding]; other site 749927020102 heterodimer interface [polypeptide binding]; other site 749927020103 phosphorylation loop region [posttranslational modification] 749927020104 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 749927020105 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 749927020106 alpha subunit interface [polypeptide binding]; other site 749927020107 TPP binding site [chemical binding]; other site 749927020108 heterodimer interface [polypeptide binding]; other site 749927020109 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 749927020110 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 749927020111 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 749927020112 acyl-activating enzyme (AAE) consensus motif; other site 749927020113 putative AMP binding site [chemical binding]; other site 749927020114 putative active site [active] 749927020115 putative CoA binding site [chemical binding]; other site 749927020116 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 749927020117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020118 NAD(P) binding site [chemical binding]; other site 749927020119 active site 749927020120 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 749927020121 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927020122 substrate binding site [chemical binding]; other site 749927020123 oxyanion hole (OAH) forming residues; other site 749927020124 trimer interface [polypeptide binding]; other site 749927020125 Putative cyclase; Region: Cyclase; pfam04199 749927020126 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927020127 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927020128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927020129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927020130 putative substrate translocation pore; other site 749927020131 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 749927020132 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 749927020133 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 749927020134 active site 749927020135 non-prolyl cis peptide bond; other site 749927020136 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927020137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927020138 DNA-binding site [nucleotide binding]; DNA binding site 749927020139 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 749927020140 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927020141 NAD(P) binding site [chemical binding]; other site 749927020142 catalytic residues [active] 749927020143 SnoaL-like domain; Region: SnoaL_4; pfam13577 749927020144 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927020145 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 749927020146 Putative cyclase; Region: Cyclase; pfam04199 749927020147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020148 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927020149 NAD(P) binding site [chemical binding]; other site 749927020150 active site 749927020151 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 749927020152 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 749927020153 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927020154 active site 749927020155 metal binding site [ion binding]; metal-binding site 749927020156 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927020157 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 749927020158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 749927020159 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927020160 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927020161 Reductase C-terminal; Region: Reductase_C; pfam14759 749927020162 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927020163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020164 NAD(P) binding site [chemical binding]; other site 749927020165 active site 749927020166 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927020167 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 749927020168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927020169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927020170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927020171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927020172 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927020173 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927020174 putative NAD(P) binding site [chemical binding]; other site 749927020175 DoxX-like family; Region: DoxX_2; pfam13564 749927020176 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 749927020177 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927020178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020179 NAD(P) binding site [chemical binding]; other site 749927020180 active site 749927020181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020182 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 749927020183 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 749927020184 Walker A/P-loop; other site 749927020185 ATP binding site [chemical binding]; other site 749927020186 Q-loop/lid; other site 749927020187 ABC transporter signature motif; other site 749927020188 Walker B; other site 749927020189 D-loop; other site 749927020190 H-loop/switch region; other site 749927020191 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 749927020192 TM-ABC transporter signature motif; other site 749927020193 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 749927020194 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 749927020195 TM-ABC transporter signature motif; other site 749927020196 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 749927020197 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 749927020198 Walker A/P-loop; other site 749927020199 ATP binding site [chemical binding]; other site 749927020200 Q-loop/lid; other site 749927020201 ABC transporter signature motif; other site 749927020202 Walker B; other site 749927020203 D-loop; other site 749927020204 H-loop/switch region; other site 749927020205 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 749927020206 putative ligand binding site [chemical binding]; other site 749927020207 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927020208 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927020209 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927020210 active site 749927020211 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927020212 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 749927020213 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 749927020214 active site 749927020215 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 749927020216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020217 NAD(P) binding site [chemical binding]; other site 749927020218 active site 749927020219 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927020220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 749927020221 DNA-binding site [nucleotide binding]; DNA binding site 749927020222 FCD domain; Region: FCD; pfam07729 749927020223 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927020224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 749927020225 DNA-binding site [nucleotide binding]; DNA binding site 749927020226 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 749927020227 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 749927020228 active site 749927020229 catalytic site [active] 749927020230 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 749927020231 active site 2 [active] 749927020232 active site 1 [active] 749927020233 short chain dehydrogenase; Provisional; Region: PRK07060 749927020234 classical (c) SDRs; Region: SDR_c; cd05233 749927020235 NAD(P) binding site [chemical binding]; other site 749927020236 active site 749927020237 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927020238 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 749927020239 NAD(P) binding site [chemical binding]; other site 749927020240 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 749927020241 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927020242 active site 749927020243 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927020244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927020245 active site 749927020246 metal binding site [ion binding]; metal-binding site 749927020247 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 749927020248 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927020249 enoyl-CoA hydratase; Provisional; Region: PRK08252 749927020250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927020251 substrate binding site [chemical binding]; other site 749927020252 oxyanion hole (OAH) forming residues; other site 749927020253 trimer interface [polypeptide binding]; other site 749927020254 Phosphotransferase enzyme family; Region: APH; pfam01636 749927020255 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 749927020256 active site 749927020257 substrate binding site [chemical binding]; other site 749927020258 ATP binding site [chemical binding]; other site 749927020259 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927020260 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927020261 active site 749927020262 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 749927020263 classical (c) SDRs; Region: SDR_c; cd05233 749927020264 NAD(P) binding site [chemical binding]; other site 749927020265 active site 749927020266 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 749927020267 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 749927020268 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927020269 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 749927020270 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 749927020271 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 749927020272 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 749927020273 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 749927020274 classical (c) SDRs; Region: SDR_c; cd05233 749927020275 NAD(P) binding site [chemical binding]; other site 749927020276 active site 749927020277 Amidohydrolase; Region: Amidohydro_2; pfam04909 749927020278 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 749927020279 DUF35 OB-fold domain; Region: DUF35; pfam01796 749927020280 lipid-transfer protein; Provisional; Region: PRK07855 749927020281 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 749927020282 active site 749927020283 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 749927020284 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927020285 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927020286 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927020287 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927020288 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 749927020289 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927020290 active site 749927020291 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927020292 active site 749927020293 metal binding site [ion binding]; metal-binding site 749927020294 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 749927020295 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927020296 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927020297 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927020298 active site 749927020299 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 749927020300 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 749927020301 classical (c) SDRs; Region: SDR_c; cd05233 749927020302 NAD(P) binding site [chemical binding]; other site 749927020303 active site 749927020304 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 749927020305 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 749927020306 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927020307 dimer interface [polypeptide binding]; other site 749927020308 active site 749927020309 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927020310 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927020311 substrate binding site [chemical binding]; other site 749927020312 oxyanion hole (OAH) forming residues; other site 749927020313 trimer interface [polypeptide binding]; other site 749927020314 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927020315 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927020316 active site 749927020317 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927020318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020319 NAD(P) binding site [chemical binding]; other site 749927020320 active site 749927020321 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927020322 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927020323 acyl-activating enzyme (AAE) consensus motif; other site 749927020324 AMP binding site [chemical binding]; other site 749927020325 active site 749927020326 CoA binding site [chemical binding]; other site 749927020327 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927020328 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927020329 acyl-activating enzyme (AAE) consensus motif; other site 749927020330 AMP binding site [chemical binding]; other site 749927020331 active site 749927020332 CoA binding site [chemical binding]; other site 749927020333 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927020334 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 749927020335 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 749927020336 acyl-activating enzyme (AAE) consensus motif; other site 749927020337 putative AMP binding site [chemical binding]; other site 749927020338 putative active site [active] 749927020339 putative CoA binding site [chemical binding]; other site 749927020340 Predicted membrane protein [Function unknown]; Region: COG2259 749927020341 enoyl-CoA hydratase; Provisional; Region: PRK06190 749927020342 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927020343 substrate binding site [chemical binding]; other site 749927020344 oxyanion hole (OAH) forming residues; other site 749927020345 trimer interface [polypeptide binding]; other site 749927020346 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927020347 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 749927020348 dimer interface [polypeptide binding]; other site 749927020349 active site 749927020350 enoyl-CoA hydratase; Provisional; Region: PRK05864 749927020351 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927020352 substrate binding site [chemical binding]; other site 749927020353 oxyanion hole (OAH) forming residues; other site 749927020354 trimer interface [polypeptide binding]; other site 749927020355 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927020356 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927020357 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927020358 active site 749927020359 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927020360 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 749927020361 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927020362 substrate binding site [chemical binding]; other site 749927020363 oxyanion hole (OAH) forming residues; other site 749927020364 trimer interface [polypeptide binding]; other site 749927020365 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 749927020366 active site 749927020367 metal binding site [ion binding]; metal-binding site 749927020368 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 749927020369 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 749927020370 substrate binding pocket [chemical binding]; other site 749927020371 dimer interface [polypeptide binding]; other site 749927020372 inhibitor binding site; inhibition site 749927020373 Amidohydrolase; Region: Amidohydro_2; pfam04909 749927020374 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 749927020375 NAD binding site [chemical binding]; other site 749927020376 catalytic residues [active] 749927020377 Predicted acyl esterases [General function prediction only]; Region: COG2936 749927020378 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 749927020379 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927020380 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 749927020381 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 749927020382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927020383 Reductase C-terminal; Region: Reductase_C; pfam14759 749927020384 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 749927020385 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927020386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020387 NAD(P) binding site [chemical binding]; other site 749927020388 active site 749927020389 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927020390 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 749927020391 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927020392 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 749927020393 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 749927020394 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 749927020395 catalytic triad [active] 749927020396 conserved cis-peptide bond; other site 749927020397 enoyl-CoA hydratase; Provisional; Region: PRK06688 749927020398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927020399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927020400 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 749927020401 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 749927020402 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 749927020403 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927020404 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927020405 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 749927020406 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927020407 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927020408 Reductase C-terminal; Region: Reductase_C; pfam14759 749927020409 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 749927020410 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927020411 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927020412 NAD(P) binding site [chemical binding]; other site 749927020413 Histidine kinase; Region: HisKA_3; pfam07730 749927020414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927020415 ATP binding site [chemical binding]; other site 749927020416 Mg2+ binding site [ion binding]; other site 749927020417 G-X-G motif; other site 749927020418 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927020419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927020420 active site 749927020421 phosphorylation site [posttranslational modification] 749927020422 intermolecular recognition site; other site 749927020423 dimerization interface [polypeptide binding]; other site 749927020424 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927020425 DNA binding residues [nucleotide binding] 749927020426 dimerization interface [polypeptide binding]; other site 749927020427 potential frameshift: common BLAST hit: gi|224989945|ref|YP_002644632.1| fatty-acid-CoA ligase 749927020428 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927020429 CoA binding site [chemical binding]; other site 749927020430 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927020431 acyl-activating enzyme (AAE) consensus motif; other site 749927020432 active site 749927020433 AMP binding site [chemical binding]; other site 749927020434 CoA binding site [chemical binding]; other site 749927020435 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927020436 galactonate dehydratase; Provisional; Region: PRK14017 749927020437 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 749927020438 active site pocket [active] 749927020439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927020440 D-galactonate transporter; Region: 2A0114; TIGR00893 749927020441 putative substrate translocation pore; other site 749927020442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927020443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927020444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927020445 dimerization interface [polypeptide binding]; other site 749927020446 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927020447 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 749927020448 catalytic residues [active] 749927020449 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927020450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020451 NAD(P) binding site [chemical binding]; other site 749927020452 active site 749927020453 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927020454 aldolase II superfamily protein; Provisional; Region: PRK07044 749927020455 intersubunit interface [polypeptide binding]; other site 749927020456 active site 749927020457 Zn2+ binding site [ion binding]; other site 749927020458 metabolite-proton symporter; Region: 2A0106; TIGR00883 749927020459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927020460 putative substrate translocation pore; other site 749927020461 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927020462 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 749927020463 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927020464 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 749927020465 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 749927020466 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 749927020467 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 749927020468 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 749927020469 Domain of unknown function (DUF336); Region: DUF336; cl01249 749927020470 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927020471 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927020472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927020473 putative substrate translocation pore; other site 749927020474 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927020475 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927020476 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927020477 DNA binding site [nucleotide binding] 749927020478 domain linker motif; other site 749927020479 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927020480 dimerization interface [polypeptide binding]; other site 749927020481 ligand binding site [chemical binding]; other site 749927020482 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927020483 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 749927020484 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927020485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927020486 dimer interface [polypeptide binding]; other site 749927020487 conserved gate region; other site 749927020488 putative PBP binding loops; other site 749927020489 ABC-ATPase subunit interface; other site 749927020490 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927020491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927020492 dimer interface [polypeptide binding]; other site 749927020493 conserved gate region; other site 749927020494 putative PBP binding loops; other site 749927020495 ABC-ATPase subunit interface; other site 749927020496 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 749927020497 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 749927020498 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927020499 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 749927020500 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 749927020501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 749927020502 DNA-binding site [nucleotide binding]; DNA binding site 749927020503 FCD domain; Region: FCD; pfam07729 749927020504 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 749927020505 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927020506 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 749927020507 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 749927020508 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 749927020509 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; cl03741 749927020510 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 749927020511 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 749927020512 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 749927020513 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 749927020514 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 749927020515 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 749927020516 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 749927020517 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 749927020518 NAD binding site [chemical binding]; other site 749927020519 ligand binding site [chemical binding]; other site 749927020520 catalytic site [active] 749927020521 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 749927020522 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 749927020523 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 749927020524 enoyl-CoA hydratase; Provisional; Region: PRK06495 749927020525 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927020526 substrate binding site [chemical binding]; other site 749927020527 oxyanion hole (OAH) forming residues; other site 749927020528 trimer interface [polypeptide binding]; other site 749927020529 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 749927020530 glutathione synthetase; Provisional; Region: PRK05246 749927020531 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 749927020532 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927020533 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927020534 active site 749927020535 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 749927020536 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927020537 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 749927020538 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 749927020539 putative C-terminal domain interface [polypeptide binding]; other site 749927020540 putative GSH binding site (G-site) [chemical binding]; other site 749927020541 putative dimer interface [polypeptide binding]; other site 749927020542 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 749927020543 N-terminal domain interface [polypeptide binding]; other site 749927020544 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 749927020545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927020546 DNA-binding site [nucleotide binding]; DNA binding site 749927020547 UTRA domain; Region: UTRA; cl17743 749927020548 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 749927020549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927020550 putative substrate translocation pore; other site 749927020551 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 749927020552 Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838 749927020553 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 749927020554 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927020555 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927020556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927020557 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 749927020558 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 749927020559 active site 749927020560 substrate binding site [chemical binding]; other site 749927020561 ATP binding site [chemical binding]; other site 749927020562 Domain of unknown function (DUF4417); Region: DUF4417; pfam14386 749927020563 ParB-like nuclease domain; Region: ParBc; pfam02195 749927020564 Replication-relaxation; Region: Replic_Relax; pfam13814 749927020565 AAA-like domain; Region: AAA_10; pfam12846 749927020566 Lsr2; Region: Lsr2; pfam11774 749927020567 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 749927020568 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 749927020569 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 749927020570 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 749927020571 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 749927020572 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 749927020573 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 749927020574 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 749927020575 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927020576 RHS Repeat; Region: RHS_repeat; pfam05593 749927020577 RHS Repeat; Region: RHS_repeat; pfam05593 749927020578 RHS Repeat; Region: RHS_repeat; pfam05593 749927020579 RHS Repeat; Region: RHS_repeat; pfam05593 749927020580 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927020581 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749927020582 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749927020583 catalytic residue [active] 749927020584 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 749927020585 NlpC/P60 family; Region: NLPC_P60; pfam00877 749927020586 AAA-like domain; Region: AAA_10; pfam12846 749927020587 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 749927020588 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 749927020589 TIGR02680 family protein; Region: TIGR02680 749927020590 Uncharacterized conserved protein [Function unknown]; Region: COG4278 749927020591 Phosphotransferase enzyme family; Region: APH; pfam01636 749927020592 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 749927020593 substrate binding site [chemical binding]; other site 749927020594 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927020595 active site 749927020596 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 749927020597 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 749927020598 substrate binding pocket [chemical binding]; other site 749927020599 dimer interface [polypeptide binding]; other site 749927020600 inhibitor binding site; inhibition site 749927020601 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 749927020602 NPCBM/NEW2 domain; Region: NPCBM; cl07060 749927020603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927020604 non-specific DNA binding site [nucleotide binding]; other site 749927020605 salt bridge; other site 749927020606 sequence-specific DNA binding site [nucleotide binding]; other site 749927020607 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 749927020608 putative transposase OrfB; Reviewed; Region: PHA02517 749927020609 HTH-like domain; Region: HTH_21; pfam13276 749927020610 Integrase core domain; Region: rve; pfam00665 749927020611 Integrase core domain; Region: rve_3; pfam13683 749927020612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 749927020613 Transposase; Region: HTH_Tnp_1; cl17663 749927020614 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927020615 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 749927020616 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927020617 hydrophobic ligand binding site; other site 749927020618 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927020619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020620 NAD(P) binding site [chemical binding]; other site 749927020621 active site 749927020622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927020623 putative DNA binding site [nucleotide binding]; other site 749927020624 putative Zn2+ binding site [ion binding]; other site 749927020625 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927020626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020627 NAD(P) binding site [chemical binding]; other site 749927020628 active site 749927020629 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 749927020630 FO synthase; Reviewed; Region: fbiC; PRK09234 749927020631 FO synthase; Reviewed; Region: fbiC; PRK09234 749927020632 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 749927020633 short chain dehydrogenase; Provisional; Region: PRK06172 749927020634 classical (c) SDRs; Region: SDR_c; cd05233 749927020635 NAD(P) binding site [chemical binding]; other site 749927020636 active site 749927020637 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 749927020638 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 749927020639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927020640 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 749927020641 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927020642 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 749927020643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927020644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927020645 DNA binding residues [nucleotide binding] 749927020646 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927020647 FAD binding domain; Region: FAD_binding_4; cl19922 749927020648 Berberine and berberine like; Region: BBE; pfam08031 749927020649 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 749927020650 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927020651 RibD C-terminal domain; Region: RibD_C; cl17279 749927020652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927020653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927020654 putative substrate translocation pore; other site 749927020655 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 749927020656 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 749927020657 Leucine rich repeat; Region: LRR_8; pfam13855 749927020658 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 749927020659 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 749927020660 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927020661 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927020662 RHS Repeat; Region: RHS_repeat; pfam05593 749927020663 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 749927020664 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 749927020665 protein-splicing catalytic site; other site 749927020666 thioester formation/cholesterol transfer; other site 749927020667 Pretoxin HINT domain; Region: PT-HINT; pfam07591 749927020668 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927020669 intermolecular salt bridges; other site 749927020670 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749927020671 Methyltransferase domain; Region: Methyltransf_23; pfam13489 749927020672 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927020673 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 749927020674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927020675 Cupin; Region: Cupin_6; pfam12852 749927020676 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 749927020677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927020678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020679 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927020680 NAD(P) binding site [chemical binding]; other site 749927020681 active site 749927020682 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927020683 active site 749927020684 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 749927020685 PBP superfamily domain; Region: PBP_like_2; pfam12849 749927020686 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 749927020687 active site 749927020688 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 749927020689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927020690 dimer interface [polypeptide binding]; other site 749927020691 conserved gate region; other site 749927020692 putative PBP binding loops; other site 749927020693 ABC-ATPase subunit interface; other site 749927020694 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 749927020695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927020696 dimer interface [polypeptide binding]; other site 749927020697 conserved gate region; other site 749927020698 putative PBP binding loops; other site 749927020699 ABC-ATPase subunit interface; other site 749927020700 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 749927020701 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 749927020702 Walker A/P-loop; other site 749927020703 ATP binding site [chemical binding]; other site 749927020704 Q-loop/lid; other site 749927020705 ABC transporter signature motif; other site 749927020706 Walker B; other site 749927020707 D-loop; other site 749927020708 H-loop/switch region; other site 749927020709 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927020710 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 749927020711 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927020712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927020713 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927020714 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927020715 active site 749927020716 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 749927020717 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 749927020718 active site 749927020719 catalytic triad [active] 749927020720 oxyanion hole [active] 749927020721 amidase; Provisional; Region: PRK06170 749927020722 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; cl12074 749927020723 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 749927020724 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927020725 NAD(P) binding site [chemical binding]; other site 749927020726 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927020727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927020728 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927020729 dimerization interface [polypeptide binding]; other site 749927020730 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927020731 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927020732 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927020733 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927020734 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927020735 putative sugar binding sites [chemical binding]; other site 749927020736 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927020737 putative sugar binding sites [chemical binding]; other site 749927020738 Q-X-W motif; other site 749927020739 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 749927020740 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 749927020741 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 749927020742 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 749927020743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020744 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 749927020745 NAD(P) binding site [chemical binding]; other site 749927020746 active site 749927020747 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 749927020748 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 749927020749 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 749927020750 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927020751 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 749927020752 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927020753 Walker A/P-loop; other site 749927020754 ATP binding site [chemical binding]; other site 749927020755 Q-loop/lid; other site 749927020756 ABC transporter signature motif; other site 749927020757 Walker B; other site 749927020758 D-loop; other site 749927020759 H-loop/switch region; other site 749927020760 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 749927020761 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 749927020762 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 749927020763 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927020764 Interdomain contacts; other site 749927020765 Cytokine receptor motif; other site 749927020766 Cellulose binding domain; Region: CBM_2; pfam00553 749927020767 alpha-galactosidase; Region: PLN02808; cl17638 749927020768 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927020769 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927020770 putative sugar binding sites [chemical binding]; other site 749927020771 Q-X-W motif; other site 749927020772 ANTAR domain; Region: ANTAR; pfam03861 749927020773 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 749927020774 putative active site [active] 749927020775 putative catalytic site [active] 749927020776 putative Zn binding site [ion binding]; other site 749927020777 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 749927020778 O-Antigen ligase; Region: Wzy_C; pfam04932 749927020779 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 749927020780 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927020781 putative ADP-binding pocket [chemical binding]; other site 749927020782 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 749927020783 beta-alpha-beta structure motif; other site 749927020784 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 749927020785 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 749927020786 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 749927020787 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927020788 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927020789 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 749927020790 Hypothetical glycosyl hydrolase family 15; Region: GHL15; pfam14885 749927020791 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 749927020792 Bacterial sugar transferase; Region: Bac_transf; pfam02397 749927020793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927020794 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 749927020795 active site 749927020796 hypothetical protein; Provisional; Region: PRK07233 749927020797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 749927020798 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 749927020799 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 749927020800 active site 749927020801 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 749927020802 homodimer interface [polypeptide binding]; other site 749927020803 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 749927020804 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 749927020805 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927020806 active site 749927020807 metal binding site [ion binding]; metal-binding site 749927020808 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 749927020809 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927020810 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927020811 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927020812 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 749927020813 metal binding site [ion binding]; metal-binding site 749927020814 active site 749927020815 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 749927020816 active site 749927020817 catalytic triad [active] 749927020818 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 749927020819 active site 749927020820 catalytic triad [active] 749927020821 oxyanion hole [active] 749927020822 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 749927020823 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 749927020824 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927020825 Interdomain contacts; other site 749927020826 Cytokine receptor motif; other site 749927020827 Cellulose binding domain; Region: CBM_2; pfam00553 749927020828 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 749927020829 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927020830 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927020831 DNA binding site [nucleotide binding] 749927020832 domain linker motif; other site 749927020833 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927020834 dimerization interface [polypeptide binding]; other site 749927020835 ligand binding site [chemical binding]; other site 749927020836 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927020837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927020838 dimer interface [polypeptide binding]; other site 749927020839 conserved gate region; other site 749927020840 putative PBP binding loops; other site 749927020841 ABC-ATPase subunit interface; other site 749927020842 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927020843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927020844 dimer interface [polypeptide binding]; other site 749927020845 putative PBP binding loops; other site 749927020846 ABC-ATPase subunit interface; other site 749927020847 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927020848 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927020849 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749927020850 active site 749927020851 catalytic triad [active] 749927020852 oxyanion hole [active] 749927020853 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927020854 anti sigma factor interaction site; other site 749927020855 regulatory phosphorylation site [posttranslational modification]; other site 749927020856 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 749927020857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927020858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927020859 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927020860 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927020861 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927020862 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927020863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927020864 PAS domain; Region: PAS_9; pfam13426 749927020865 putative active site [active] 749927020866 heme pocket [chemical binding]; other site 749927020867 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927020868 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927020869 anti sigma factor interaction site; other site 749927020870 regulatory phosphorylation site [posttranslational modification]; other site 749927020871 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 749927020872 dimer interface [polypeptide binding]; other site 749927020873 active site 749927020874 catalytic residue [active] 749927020875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927020876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927020877 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 749927020878 putative dimerization interface [polypeptide binding]; other site 749927020879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927020880 S-adenosylmethionine binding site [chemical binding]; other site 749927020881 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 749927020882 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 749927020883 glutaminase active site [active] 749927020884 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 749927020885 dimer interface [polypeptide binding]; other site 749927020886 active site 749927020887 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 749927020888 dimer interface [polypeptide binding]; other site 749927020889 active site 749927020890 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 749927020891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927020892 Reductase C-terminal; Region: Reductase_C; pfam14759 749927020893 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 749927020894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927020895 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927020896 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927020897 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927020898 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927020899 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927020900 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927020901 active site 749927020902 catalytic tetrad [active] 749927020903 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927020904 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927020905 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927020906 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927020907 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 749927020908 Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662 749927020909 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927020910 Interdomain contacts; other site 749927020911 Cytokine receptor motif; other site 749927020912 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 749927020913 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 749927020914 active site 749927020915 PHP Thumb interface [polypeptide binding]; other site 749927020916 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 749927020917 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 749927020918 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 749927020919 generic binding surface I; other site 749927020920 generic binding surface II; other site 749927020921 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927020922 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927020923 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927020924 DNA binding residues [nucleotide binding] 749927020925 YCII-related domain; Region: YCII; cl00999 749927020926 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 749927020927 NADP+ binding site [chemical binding]; other site 749927020928 arginine decarboxylase; Provisional; Region: PRK15029 749927020929 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 749927020930 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927020931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927020932 catalytic residue [active] 749927020933 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 749927020934 Y-family of DNA polymerases; Region: PolY; cl12025 749927020935 DNA binding site [nucleotide binding] 749927020936 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 749927020937 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927020938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927020939 DNA-binding site [nucleotide binding]; DNA binding site 749927020940 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927020941 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927020942 Walker A/P-loop; other site 749927020943 ATP binding site [chemical binding]; other site 749927020944 Q-loop/lid; other site 749927020945 ABC transporter signature motif; other site 749927020946 Walker B; other site 749927020947 D-loop; other site 749927020948 H-loop/switch region; other site 749927020949 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927020950 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927020951 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927020952 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927020953 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927020954 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927020955 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927020956 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 749927020957 active site 749927020958 catalytic triad [active] 749927020959 oxyanion hole [active] 749927020960 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927020961 classical (c) SDRs; Region: SDR_c; cd05233 749927020962 NAD(P) binding site [chemical binding]; other site 749927020963 active site 749927020964 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 749927020965 Ferritin-like domain; Region: Ferritin; pfam00210 749927020966 ferroxidase diiron center [ion binding]; other site 749927020967 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 749927020968 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 749927020969 CoenzymeA binding site [chemical binding]; other site 749927020970 subunit interaction site [polypeptide binding]; other site 749927020971 PHB binding site; other site 749927020972 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 749927020973 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 749927020974 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 749927020975 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 749927020976 G1 box; other site 749927020977 GTP/Mg2+ binding site [chemical binding]; other site 749927020978 G2 box; other site 749927020979 Switch I region; other site 749927020980 G3 box; other site 749927020981 Switch II region; other site 749927020982 G4 box; other site 749927020983 G5 box; other site 749927020984 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927020985 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 749927020986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927020987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927020988 dimerization interface [polypeptide binding]; other site 749927020989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927020990 ATP binding site [chemical binding]; other site 749927020991 Mg2+ binding site [ion binding]; other site 749927020992 G-X-G motif; other site 749927020993 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927020994 dimerization interface [polypeptide binding]; other site 749927020995 putative DNA binding site [nucleotide binding]; other site 749927020996 putative Zn2+ binding site [ion binding]; other site 749927020997 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927020998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927020999 NAD(P) binding site [chemical binding]; other site 749927021000 active site 749927021001 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 749927021002 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927021003 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927021004 AAA ATPase domain; Region: AAA_16; pfam13191 749927021005 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927021006 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927021007 DNA binding residues [nucleotide binding] 749927021008 dimerization interface [polypeptide binding]; other site 749927021009 Tannase and feruloyl esterase; Region: Tannase; pfam07519 749927021010 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927021011 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927021012 active site 749927021013 catalytic tetrad [active] 749927021014 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 749927021015 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927021016 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 749927021017 active site 749927021018 GAF domain; Region: GAF_2; pfam13185 749927021019 ANTAR domain; Region: ANTAR; pfam03861 749927021020 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 749927021021 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 749927021022 Ricin-type beta-trefoil; Region: RICIN; smart00458 749927021023 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927021024 putative sugar binding sites [chemical binding]; other site 749927021025 Q-X-W motif; other site 749927021026 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 749927021027 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 749927021028 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 749927021029 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 749927021030 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927021031 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927021032 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927021033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927021034 dimer interface [polypeptide binding]; other site 749927021035 conserved gate region; other site 749927021036 putative PBP binding loops; other site 749927021037 ABC-ATPase subunit interface; other site 749927021038 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 749927021039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927021040 dimer interface [polypeptide binding]; other site 749927021041 conserved gate region; other site 749927021042 putative PBP binding loops; other site 749927021043 ABC-ATPase subunit interface; other site 749927021044 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927021045 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927021046 DNA binding site [nucleotide binding] 749927021047 domain linker motif; other site 749927021048 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 749927021049 ligand binding site [chemical binding]; other site 749927021050 dimerization interface (open form) [polypeptide binding]; other site 749927021051 dimerization interface (closed form) [polypeptide binding]; other site 749927021052 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 749927021053 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927021054 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927021055 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927021056 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 749927021057 putative NAD(P) binding site [chemical binding]; other site 749927021058 tetracycline repressor protein TetR; Provisional; Region: PRK13756 749927021059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927021060 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927021061 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927021062 Fasciclin domain; Region: Fasciclin; pfam02469 749927021063 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 749927021064 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 749927021065 Moco binding site; other site 749927021066 metal coordination site [ion binding]; other site 749927021067 putative anti-sigmaE protein; Provisional; Region: PRK13920 749927021068 Putative zinc-finger; Region: zf-HC2; pfam13490 749927021069 Anti-sigma-K factor rskA; Region: RskA; pfam10099 749927021070 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 749927021071 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927021072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927021073 DNA binding residues [nucleotide binding] 749927021074 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 749927021075 acyl-CoA synthetase; Validated; Region: PRK06188 749927021076 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927021077 acyl-activating enzyme (AAE) consensus motif; other site 749927021078 AMP binding site [chemical binding]; other site 749927021079 active site 749927021080 CoA binding site [chemical binding]; other site 749927021081 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 749927021082 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 749927021083 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 749927021084 Protein of unknown function (DUF1611); Region: DUF1611; cl19508 749927021085 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 749927021086 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927021087 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 749927021088 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 749927021089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927021090 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 749927021091 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 749927021092 RNA binding surface [nucleotide binding]; other site 749927021093 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927021094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927021095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927021096 DNA binding residues [nucleotide binding] 749927021097 Cupin domain; Region: Cupin_2; cl17218 749927021098 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 749927021099 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927021100 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927021101 DNA binding residues [nucleotide binding] 749927021102 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927021103 Amidohydrolase; Region: Amidohydro_4; pfam13147 749927021104 active site 749927021105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927021106 metal binding site [ion binding]; metal-binding site 749927021107 active site 749927021108 I-site; other site 749927021109 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 749927021110 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 749927021111 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927021112 Glyco_18 domain; Region: Glyco_18; smart00636 749927021113 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 749927021114 active site 749927021115 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 749927021116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927021117 catalytic residue [active] 749927021118 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927021119 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927021120 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 749927021121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927021122 S-adenosylmethionine binding site [chemical binding]; other site 749927021123 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927021124 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 749927021125 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927021126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927021127 non-specific DNA binding site [nucleotide binding]; other site 749927021128 salt bridge; other site 749927021129 sequence-specific DNA binding site [nucleotide binding]; other site 749927021130 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 749927021131 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 749927021132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927021133 S-adenosylmethionine binding site [chemical binding]; other site 749927021134 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927021135 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 749927021136 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 749927021137 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; cl10513 749927021138 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 749927021139 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927021140 Methyltransferase domain; Region: Methyltransf_24; pfam13578 749927021141 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 749927021142 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 749927021143 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 749927021144 metal ion-dependent adhesion site (MIDAS); other site 749927021145 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 749927021146 active site 749927021147 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 749927021148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927021149 DNA-binding site [nucleotide binding]; DNA binding site 749927021150 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927021151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927021152 homodimer interface [polypeptide binding]; other site 749927021153 catalytic residue [active] 749927021154 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 749927021155 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927021156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927021157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927021158 putative substrate translocation pore; other site 749927021159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927021160 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927021161 putative substrate translocation pore; other site 749927021162 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927021163 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927021164 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 749927021165 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 749927021166 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927021167 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 749927021168 protein binding site [polypeptide binding]; other site 749927021169 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 749927021170 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 749927021171 NAD binding site [chemical binding]; other site 749927021172 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927021173 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 749927021174 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 749927021175 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 749927021176 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 749927021177 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 749927021178 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 749927021179 putative active site [active] 749927021180 putative substrate binding site [chemical binding]; other site 749927021181 putative cosubstrate binding site; other site 749927021182 catalytic site [active] 749927021183 Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893 749927021184 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 749927021185 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 749927021186 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927021187 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 749927021188 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 749927021189 sarcosine oxidase, delta subunit family, heterotetrameric form; Region: soxD; TIGR01374 749927021190 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 749927021191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927021192 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 749927021193 dimer interface [polypeptide binding]; other site 749927021194 active site 749927021195 glycine-pyridoxal phosphate binding site [chemical binding]; other site 749927021196 folate binding site [chemical binding]; other site 749927021197 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 749927021198 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927021199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927021200 DNA-binding site [nucleotide binding]; DNA binding site 749927021201 FCD domain; Region: FCD; pfam07729 749927021202 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 749927021203 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 749927021204 [2Fe-2S] cluster binding site [ion binding]; other site 749927021205 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 749927021206 putative alpha subunit interface [polypeptide binding]; other site 749927021207 putative active site [active] 749927021208 putative substrate binding site [chemical binding]; other site 749927021209 Fe binding site [ion binding]; other site 749927021210 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 749927021211 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927021212 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 749927021213 NAD(P) binding site [chemical binding]; other site 749927021214 catalytic residues [active] 749927021215 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 749927021216 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927021217 choline dehydrogenase; Validated; Region: PRK02106 749927021218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927021219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927021220 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 749927021221 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 749927021222 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 749927021223 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 749927021224 [2Fe-2S] cluster binding site [ion binding]; other site 749927021225 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 749927021226 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927021227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927021228 Reductase C-terminal; Region: Reductase_C; pfam14759 749927021229 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927021230 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927021231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927021232 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 749927021233 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 749927021234 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 749927021235 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749927021236 E3 interaction surface; other site 749927021237 lipoyl attachment site [posttranslational modification]; other site 749927021238 e3 binding domain; Region: E3_binding; pfam02817 749927021239 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 749927021240 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 749927021241 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 749927021242 alpha subunit interface [polypeptide binding]; other site 749927021243 TPP binding site [chemical binding]; other site 749927021244 heterodimer interface [polypeptide binding]; other site 749927021245 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 749927021246 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 749927021247 tetramer interface [polypeptide binding]; other site 749927021248 TPP-binding site [chemical binding]; other site 749927021249 heterodimer interface [polypeptide binding]; other site 749927021250 phosphorylation loop region [posttranslational modification] 749927021251 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927021252 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 749927021253 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 749927021254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927021255 Coenzyme A binding pocket [chemical binding]; other site 749927021256 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 749927021257 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 749927021258 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 749927021259 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927021260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927021261 active site 749927021262 phosphorylation site [posttranslational modification] 749927021263 intermolecular recognition site; other site 749927021264 dimerization interface [polypeptide binding]; other site 749927021265 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927021266 DNA binding site [nucleotide binding] 749927021267 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927021268 dimerization interface [polypeptide binding]; other site 749927021269 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 749927021270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927021271 dimer interface [polypeptide binding]; other site 749927021272 phosphorylation site [posttranslational modification] 749927021273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927021274 ATP binding site [chemical binding]; other site 749927021275 Mg2+ binding site [ion binding]; other site 749927021276 G-X-G motif; other site 749927021277 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 749927021278 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927021279 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927021280 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927021281 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927021282 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 749927021283 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927021284 Interdomain contacts; other site 749927021285 Cytokine receptor motif; other site 749927021286 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 749927021287 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 749927021288 putative active site [active] 749927021289 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927021290 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927021291 active site 749927021292 ATP binding site [chemical binding]; other site 749927021293 substrate binding site [chemical binding]; other site 749927021294 activation loop (A-loop); other site 749927021295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927021296 dimerization interface [polypeptide binding]; other site 749927021297 putative DNA binding site [nucleotide binding]; other site 749927021298 putative Zn2+ binding site [ion binding]; other site 749927021299 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 749927021300 putative hydrophobic ligand binding site [chemical binding]; other site 749927021301 Imelysin; Region: Peptidase_M75; pfam09375 749927021302 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 749927021303 Phosphoesterase family; Region: Phosphoesterase; pfam04185 749927021304 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 749927021305 Mg2+ binding site [ion binding]; other site 749927021306 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 749927021307 anti sigma factor interaction site; other site 749927021308 regulatory phosphorylation site [posttranslational modification]; other site 749927021309 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927021310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927021311 active site 749927021312 phosphorylation site [posttranslational modification] 749927021313 intermolecular recognition site; other site 749927021314 dimerization interface [polypeptide binding]; other site 749927021315 CHASE3 domain; Region: CHASE3; cl05000 749927021316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927021317 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927021318 dimerization interface [polypeptide binding]; other site 749927021319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927021320 dimer interface [polypeptide binding]; other site 749927021321 phosphorylation site [posttranslational modification] 749927021322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927021323 ATP binding site [chemical binding]; other site 749927021324 Mg2+ binding site [ion binding]; other site 749927021325 G-X-G motif; other site 749927021326 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927021327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927021328 active site 749927021329 phosphorylation site [posttranslational modification] 749927021330 intermolecular recognition site; other site 749927021331 dimerization interface [polypeptide binding]; other site 749927021332 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 749927021333 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl19860 749927021334 Secretory lipase; Region: LIP; pfam03583 749927021335 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927021336 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927021337 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927021338 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927021339 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927021340 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927021341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927021342 short chain dehydrogenase; Region: adh_short; pfam00106 749927021343 NAD(P) binding site [chemical binding]; other site 749927021344 active site 749927021345 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927021346 mce related protein; Region: MCE; pfam02470 749927021347 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927021348 mce related protein; Region: MCE; pfam02470 749927021349 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927021350 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927021351 mce related protein; Region: MCE; pfam02470 749927021352 HAUS augmin-like complex subunit 4; Region: HAUS4; pfam14735 749927021353 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927021354 mce related protein; Region: MCE; pfam02470 749927021355 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927021356 mce related protein; Region: MCE; pfam02470 749927021357 mce related protein; Region: MCE; pfam02470 749927021358 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 749927021359 Permease; Region: Permease; pfam02405 749927021360 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 749927021361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927021362 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 749927021363 Walker A/P-loop; other site 749927021364 ATP binding site [chemical binding]; other site 749927021365 Q-loop/lid; other site 749927021366 ABC transporter signature motif; other site 749927021367 Walker B; other site 749927021368 D-loop; other site 749927021369 H-loop/switch region; other site 749927021370 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 749927021371 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927021372 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 749927021373 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927021374 binding surface 749927021375 TPR motif; other site 749927021376 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927021377 CHAT domain; Region: CHAT; pfam12770 749927021378 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927021379 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927021380 active site 749927021381 metal binding site [ion binding]; metal-binding site 749927021382 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 749927021383 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 749927021384 nudix motif; other site 749927021385 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927021386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927021387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927021388 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927021389 RibD C-terminal domain; Region: RibD_C; cl17279 749927021390 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 749927021391 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 749927021392 Phosphotransferase enzyme family; Region: APH; pfam01636 749927021393 active site 749927021394 ATP binding site [chemical binding]; other site 749927021395 substrate binding site [chemical binding]; other site 749927021396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927021397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927021398 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927021399 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 749927021400 Hemerythrin-like domain; Region: Hr-like; cd12108 749927021401 Fe binding site [ion binding]; other site 749927021402 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 749927021403 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927021404 acyl-activating enzyme (AAE) consensus motif; other site 749927021405 AMP binding site [chemical binding]; other site 749927021406 active site 749927021407 CoA binding site [chemical binding]; other site 749927021408 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 749927021409 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749927021410 molybdopterin cofactor binding site; other site 749927021411 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 749927021412 molybdopterin cofactor binding site; other site 749927021413 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927021414 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927021415 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 749927021416 hydrophobic ligand binding site; other site 749927021417 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927021418 Cupin domain; Region: Cupin_2; cl17218 749927021419 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 749927021420 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 749927021421 conserved cys residue [active] 749927021422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927021423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927021424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927021425 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927021426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927021427 Coenzyme A binding pocket [chemical binding]; other site 749927021428 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 749927021429 Protein of unknown function DUF111; Region: DUF111; cl03398 749927021430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927021431 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927021432 putative substrate translocation pore; other site 749927021433 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927021434 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927021435 zinc-finger binding domain of transposase IS66; Region: zf-IS66; pfam13005 749927021436 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 749927021437 Domain of unknown function (DUF222); Region: DUF222; pfam02720 749927021438 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 749927021439 active site 749927021440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927021441 Coenzyme A binding pocket [chemical binding]; other site 749927021442 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 749927021443 short chain dehydrogenase; Provisional; Region: PRK07041 749927021444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927021445 NAD(P) binding site [chemical binding]; other site 749927021446 active site 749927021447 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 749927021448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927021449 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 749927021450 dimerization interface [polypeptide binding]; other site 749927021451 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 749927021452 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749927021453 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749927021454 catalytic residue [active] 749927021455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927021456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927021457 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927021458 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 749927021459 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 749927021460 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 749927021461 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 749927021462 putative active site [active] 749927021463 putative metal binding site [ion binding]; other site 749927021464 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927021465 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927021466 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 749927021467 putative ADP-ribose binding site [chemical binding]; other site 749927021468 putative active site [active] 749927021469 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 749927021470 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 749927021471 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927021472 motif II; other site 749927021473 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 749927021474 nudix motif; other site 749927021475 Predicted membrane protein [Function unknown]; Region: COG2259 749927021476 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 749927021477 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 749927021478 G1 box; other site 749927021479 GTP/Mg2+ binding site [chemical binding]; other site 749927021480 G2 box; other site 749927021481 Switch I region; other site 749927021482 G3 box; other site 749927021483 Switch II region; other site 749927021484 G4 box; other site 749927021485 G5 box; other site 749927021486 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927021487 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 749927021488 Nitrate and nitrite sensing; Region: NIT; pfam08376 749927021489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927021490 ATP binding site [chemical binding]; other site 749927021491 Mg2+ binding site [ion binding]; other site 749927021492 G-X-G motif; other site 749927021493 variable surface protein Vir28; Provisional; Region: PTZ00249 749927021494 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 749927021495 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 749927021496 acyl-activating enzyme (AAE) consensus motif; other site 749927021497 putative AMP binding site [chemical binding]; other site 749927021498 putative active site [active] 749927021499 putative CoA binding site [chemical binding]; other site 749927021500 short chain dehydrogenase; Provisional; Region: PRK12939 749927021501 classical (c) SDRs; Region: SDR_c; cd05233 749927021502 NAD(P) binding site [chemical binding]; other site 749927021503 active site 749927021504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927021505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927021506 putative substrate translocation pore; other site 749927021507 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927021508 metal binding site [ion binding]; metal-binding site 749927021509 active site 749927021510 I-site; other site 749927021511 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 749927021512 Transcriptional regulator [Transcription]; Region: LytR; COG1316 749927021513 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 749927021514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927021515 non-specific DNA binding site [nucleotide binding]; other site 749927021516 salt bridge; other site 749927021517 sequence-specific DNA binding site [nucleotide binding]; other site 749927021518 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 749927021519 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 749927021520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927021521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927021522 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 749927021523 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 749927021524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927021525 NAD(P) binding site [chemical binding]; other site 749927021526 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 749927021527 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 749927021528 conserved cys residue [active] 749927021529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927021530 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927021531 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927021532 active site 749927021533 catalytic tetrad [active] 749927021534 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 749927021535 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 749927021536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927021537 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 749927021538 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 749927021539 catalytic triad [active] 749927021540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927021541 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 749927021542 active site 749927021543 dimerization interface [polypeptide binding]; other site 749927021544 ribonuclease PH; Reviewed; Region: rph; PRK00173 749927021545 Ribonuclease PH; Region: RNase_PH_bact; cd11362 749927021546 hexamer interface [polypeptide binding]; other site 749927021547 active site 749927021548 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 749927021549 glutamate racemase; Provisional; Region: PRK00865 749927021550 Rhomboid family; Region: Rhomboid; pfam01694 749927021551 N-acetyltransferase; Region: Acetyltransf_2; cl00949 749927021552 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 749927021553 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 749927021554 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927021555 cysteine synthase; Region: PLN02565 749927021556 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 749927021557 dimer interface [polypeptide binding]; other site 749927021558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927021559 catalytic residue [active] 749927021560 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 749927021561 MoaE interaction surface [polypeptide binding]; other site 749927021562 MoeB interaction surface [polypeptide binding]; other site 749927021563 thiocarboxylated glycine; other site 749927021564 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 749927021565 MPN+ (JAMM) motif; other site 749927021566 Zinc-binding site [ion binding]; other site 749927021567 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 749927021568 putative active site pocket [active] 749927021569 cleavage site 749927021570 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 749927021571 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 749927021572 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 749927021573 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 749927021574 active site 749927021575 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 749927021576 catalytic triad [active] 749927021577 conserved cis-peptide bond; other site 749927021578 Entner-Doudoroff aldolase; Region: eda; TIGR01182 749927021579 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 749927021580 active site 749927021581 intersubunit interface [polypeptide binding]; other site 749927021582 catalytic residue [active] 749927021583 BioY family; Region: BioY; pfam02632 749927021584 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 749927021585 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 749927021586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 749927021587 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 749927021588 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 749927021589 Peptidyl-tRNA hydrolase PTH2; Region: PTH2; cl19212 749927021590 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 749927021591 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 749927021592 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 749927021593 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 749927021594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927021595 motif II; other site 749927021596 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 749927021597 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 749927021598 D-pathway; other site 749927021599 Putative ubiquinol binding site [chemical binding]; other site 749927021600 Low-spin heme (heme b) binding site [chemical binding]; other site 749927021601 Putative water exit pathway; other site 749927021602 Binuclear center (heme o3/CuB) [ion binding]; other site 749927021603 K-pathway; other site 749927021604 Putative proton exit pathway; other site 749927021605 Phosphotransferase enzyme family; Region: APH; pfam01636 749927021606 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 749927021607 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927021608 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 749927021609 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927021610 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927021611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927021612 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 749927021613 active site 749927021614 Transposase; Region: HTH_Tnp_1; cl17663 749927021615 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 749927021616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 749927021617 HTH-like domain; Region: HTH_21; pfam13276 749927021618 Integrase core domain; Region: rve; pfam00665 749927021619 Integrase core domain; Region: rve_3; pfam13683 749927021620 Sulfatase; Region: Sulfatase; cl19157 749927021621 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 749927021622 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927021623 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927021624 catalytic residue [active] 749927021625 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927021626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927021627 putative DNA binding site [nucleotide binding]; other site 749927021628 putative Zn2+ binding site [ion binding]; other site 749927021629 AsnC family; Region: AsnC_trans_reg; pfam01037 749927021630 AAA domain; Region: AAA_17; cl19128 749927021631 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 749927021632 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927021633 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927021634 putative DNA binding site [nucleotide binding]; other site 749927021635 putative Zn2+ binding site [ion binding]; other site 749927021636 AsnC family; Region: AsnC_trans_reg; pfam01037 749927021637 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927021638 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 749927021639 nucleoside/Zn binding site; other site 749927021640 dimer interface [polypeptide binding]; other site 749927021641 catalytic motif [active] 749927021642 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 749927021643 homodimer interaction site [polypeptide binding]; other site 749927021644 cofactor binding site; other site 749927021645 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 749927021646 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927021647 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927021648 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 749927021649 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927021650 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927021651 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 749927021652 active site 749927021653 active pocket/dimerization site; other site 749927021654 phosphorylation site [posttranslational modification] 749927021655 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 749927021656 dimerization domain swap beta strand [polypeptide binding]; other site 749927021657 regulatory protein interface [polypeptide binding]; other site 749927021658 active site 749927021659 regulatory phosphorylation site [posttranslational modification]; other site 749927021660 DAK2 domain; Region: Dak2; cl03685 749927021661 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 749927021662 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 749927021663 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 749927021664 Na binding site [ion binding]; other site 749927021665 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 749927021666 hypothetical protein; Provisional; Region: PRK03298 749927021667 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 749927021668 dimer interface [polypeptide binding]; other site 749927021669 ADP-ribose binding site [chemical binding]; other site 749927021670 active site 749927021671 nudix motif; other site 749927021672 metal binding site [ion binding]; metal-binding site 749927021673 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 749927021674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927021675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927021676 enoyl-CoA hydratase; Validated; Region: PRK08139 749927021677 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927021678 substrate binding site [chemical binding]; other site 749927021679 oxyanion hole (OAH) forming residues; other site 749927021680 trimer interface [polypeptide binding]; other site 749927021681 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 749927021682 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 749927021683 conserved cys residue [active] 749927021684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927021685 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 749927021686 catalytic triad [active] 749927021687 conserved cis-peptide bond; other site 749927021688 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 749927021689 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 749927021690 B12 binding site [chemical binding]; other site 749927021691 cobalt ligand [ion binding]; other site 749927021692 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 749927021693 Bacterial PH domain; Region: bPH_2; cl01348 749927021694 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 749927021695 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 749927021696 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927021697 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927021698 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927021699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927021700 NAD(P) binding site [chemical binding]; other site 749927021701 active site 749927021702 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 749927021703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927021704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927021705 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 749927021706 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 749927021707 hinge; other site 749927021708 active site 749927021709 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 749927021710 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 749927021711 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 749927021712 hinge; other site 749927021713 active site 749927021714 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 749927021715 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 749927021716 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 749927021717 gamma subunit interface [polypeptide binding]; other site 749927021718 epsilon subunit interface [polypeptide binding]; other site 749927021719 LBP interface [polypeptide binding]; other site 749927021720 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 749927021721 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 749927021722 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 749927021723 alpha subunit interaction interface [polypeptide binding]; other site 749927021724 Walker A motif; other site 749927021725 ATP binding site [chemical binding]; other site 749927021726 Walker B motif; other site 749927021727 inhibitor binding site; inhibition site 749927021728 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 749927021729 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 749927021730 core domain interface [polypeptide binding]; other site 749927021731 delta subunit interface [polypeptide binding]; other site 749927021732 epsilon subunit interface [polypeptide binding]; other site 749927021733 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 749927021734 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 749927021735 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 749927021736 beta subunit interaction interface [polypeptide binding]; other site 749927021737 Walker A motif; other site 749927021738 ATP binding site [chemical binding]; other site 749927021739 Walker B motif; other site 749927021740 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 749927021741 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 749927021742 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 749927021743 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 749927021744 ATP synthase subunit C; Region: ATP-synt_C; cl00466 749927021745 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 749927021746 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 749927021747 Mg++ binding site [ion binding]; other site 749927021748 putative catalytic motif [active] 749927021749 substrate binding site [chemical binding]; other site 749927021750 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 749927021751 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 749927021752 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 749927021753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927021754 S-adenosylmethionine binding site [chemical binding]; other site 749927021755 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 749927021756 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 749927021757 Ligand binding site; other site 749927021758 Putative Catalytic site; other site 749927021759 DXD motif; other site 749927021760 GtrA-like protein; Region: GtrA; pfam04138 749927021761 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 749927021762 peptide chain release factor 1; Validated; Region: prfA; PRK00591 749927021763 This domain is found in peptide chain release factors; Region: PCRF; smart00937 749927021764 RF-1 domain; Region: RF-1; pfam00472 749927021765 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 749927021766 transcription termination factor Rho; Provisional; Region: PRK12678 749927021767 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 749927021768 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 749927021769 RNA binding site [nucleotide binding]; other site 749927021770 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 749927021771 multimer interface [polypeptide binding]; other site 749927021772 Walker A motif; other site 749927021773 ATP binding site [chemical binding]; other site 749927021774 Walker B motif; other site 749927021775 homoserine kinase; Provisional; Region: PRK01212 749927021776 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 749927021777 homodimer interface [polypeptide binding]; other site 749927021778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927021779 catalytic residue [active] 749927021780 homoserine dehydrogenase; Provisional; Region: PRK06349 749927021781 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 749927021782 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 749927021783 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 749927021784 diaminopimelate decarboxylase; Region: lysA; TIGR01048 749927021785 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 749927021786 active site 749927021787 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749927021788 substrate binding site [chemical binding]; other site 749927021789 catalytic residues [active] 749927021790 dimer interface [polypeptide binding]; other site 749927021791 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 749927021792 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 749927021793 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 749927021794 active site 749927021795 HIGH motif; other site 749927021796 KMSK motif region; other site 749927021797 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 749927021798 tRNA binding surface [nucleotide binding]; other site 749927021799 anticodon binding site; other site 749927021800 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 749927021801 Domain of unknown function (DUF305); Region: DUF305; pfam03713 749927021802 RIP homotypic interaction motif; Region: RHIM; pfam12721 749927021803 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 749927021804 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927021805 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927021806 short chain dehydrogenase; Provisional; Region: PRK06180 749927021807 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 749927021808 NADP binding site [chemical binding]; other site 749927021809 active site 749927021810 steroid binding site; other site 749927021811 Epoxide hydrolase N terminus; Region: EHN; pfam06441 749927021812 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927021813 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 749927021814 active site 749927021815 catalytic residues [active] 749927021816 DNA binding site [nucleotide binding] 749927021817 Int/Topo IB signature motif; other site 749927021818 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927021819 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 749927021820 putative NAD(P) binding site [chemical binding]; other site 749927021821 TIGR03086 family protein; Region: TIGR03086 749927021822 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927021823 Helix-turn-helix domain; Region: HTH_18; pfam12833 749927021824 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927021825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 749927021826 Transposase; Region: HTH_Tnp_1; cl17663 749927021827 putative transposase OrfB; Reviewed; Region: PHA02517 749927021828 HTH-like domain; Region: HTH_21; pfam13276 749927021829 Integrase core domain; Region: rve; pfam00665 749927021830 Integrase core domain; Region: rve_3; pfam13683 749927021831 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 749927021832 substrate binding site [chemical binding]; other site 749927021833 ATP binding site [chemical binding]; other site 749927021834 Survival protein SurE; Region: SurE; cl00448 749927021835 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927021836 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 749927021837 DNA binding site [nucleotide binding] 749927021838 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927021839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927021840 TPR repeat; Region: TPR_11; pfam13414 749927021841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927021842 TPR motif; other site 749927021843 binding surface 749927021844 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927021845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927021846 TPR motif; other site 749927021847 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927021848 binding surface 749927021849 Cytochrome P450; Region: p450; cl12078 749927021850 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 749927021851 Right handed beta helix region; Region: Beta_helix; pfam13229 749927021852 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927021853 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927021854 putative sugar binding sites [chemical binding]; other site 749927021855 Q-X-W motif; other site 749927021856 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927021857 Interdomain contacts; other site 749927021858 Cytokine receptor motif; other site 749927021859 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927021860 Interdomain contacts; other site 749927021861 Cytokine receptor motif; other site 749927021862 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 749927021863 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 749927021864 alpha-galactosidase; Region: PLN02808; cl17638 749927021865 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927021866 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927021867 putative sugar binding sites [chemical binding]; other site 749927021868 Q-X-W motif; other site 749927021869 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927021870 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927021871 putative sugar binding sites [chemical binding]; other site 749927021872 Q-X-W motif; other site 749927021873 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 749927021874 active site 749927021875 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 749927021876 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 749927021877 Interdomain contacts; other site 749927021878 Cytokine receptor motif; other site 749927021879 Cellulose binding domain; Region: CBM_2; cl17741 749927021880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927021881 putative DNA binding site [nucleotide binding]; other site 749927021882 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927021883 putative Zn2+ binding site [ion binding]; other site 749927021884 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927021885 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927021886 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 749927021887 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 749927021888 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 749927021889 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 749927021890 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927021891 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927021892 putative sugar binding sites [chemical binding]; other site 749927021893 Q-X-W motif; other site 749927021894 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 749927021895 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927021896 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927021897 putative sugar binding sites [chemical binding]; other site 749927021898 Q-X-W motif; other site 749927021899 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 749927021900 pyruvate carboxylase subunit B; Provisional; Region: PRK14042 749927021901 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 749927021902 Cellulose binding domain; Region: CBM_2; pfam00553 749927021903 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 749927021904 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927021905 DNA binding residues [nucleotide binding] 749927021906 dimer interface [polypeptide binding]; other site 749927021907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927021908 Mg2+ binding site [ion binding]; other site 749927021909 G-X-G motif; other site 749927021910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927021911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927021912 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927021913 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927021914 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927021915 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 749927021916 mce related protein; Region: MCE; pfam02470 749927021917 DNA circularisation protein N-terminus; Region: DNA_circ_N; cl19561 749927021918 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 749927021919 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 749927021920 Transposase IS4; Region: DDE_Tnp_1_7; pfam13843 749927021921 Transposase [DNA replication, recombination, and repair]; Region: COG5433 749927021922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927021923 S-adenosylmethionine binding site [chemical binding]; other site 749927021924 PAC2 family; Region: PAC2; pfam09754 749927021925 Bacterial PH domain; Region: bPH_2; cl01348 749927021926 Predicted membrane protein [Function unknown]; Region: COG3428 749927021927 Bacterial PH domain; Region: bPH_2; pfam03703 749927021928 Bacterial PH domain; Region: bPH_2; pfam03703 749927021929 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 749927021930 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927021931 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927021932 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927021933 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927021934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927021935 Coenzyme A binding pocket [chemical binding]; other site 749927021936 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927021937 active site 749927021938 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927021939 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927021940 inhibitor-cofactor binding pocket; inhibition site 749927021941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927021942 catalytic residue [active] 749927021943 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 749927021944 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927021945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927021946 putative DNA binding site [nucleotide binding]; other site 749927021947 putative Zn2+ binding site [ion binding]; other site 749927021948 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927021949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927021950 DNA-binding site [nucleotide binding]; DNA binding site 749927021951 FCD domain; Region: FCD; pfam07729 749927021952 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 749927021953 classical (c) SDRs; Region: SDR_c; cd05233 749927021954 NAD(P) binding site [chemical binding]; other site 749927021955 active site 749927021956 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 749927021957 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 749927021958 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 749927021959 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 749927021960 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 749927021961 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749927021962 PYR/PP interface [polypeptide binding]; other site 749927021963 dimer interface [polypeptide binding]; other site 749927021964 TPP binding site [chemical binding]; other site 749927021965 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927021966 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 749927021967 TPP-binding site [chemical binding]; other site 749927021968 FAD dependent oxidoreductase; Region: DAO; pfam01266 749927021969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927021970 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 749927021971 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 749927021972 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 749927021973 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 749927021974 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 749927021975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927021976 FeS/SAM binding site; other site 749927021977 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 749927021978 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 749927021979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927021980 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927021981 putative substrate translocation pore; other site 749927021982 proline racemase; Provisional; Region: PRK13969 749927021983 putative amidase; Provisional; Region: PRK06169 749927021984 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 749927021985 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 749927021986 NAD binding site [chemical binding]; other site 749927021987 ligand binding site [chemical binding]; other site 749927021988 catalytic site [active] 749927021989 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 749927021990 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 749927021991 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927021992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927021993 DNA-binding site [nucleotide binding]; DNA binding site 749927021994 FCD domain; Region: FCD; pfam07729 749927021995 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 749927021996 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 749927021997 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 749927021998 tetramerization interface [polypeptide binding]; other site 749927021999 NAD(P) binding site [chemical binding]; other site 749927022000 catalytic residues [active] 749927022001 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927022002 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927022003 inhibitor-cofactor binding pocket; inhibition site 749927022004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927022005 catalytic residue [active] 749927022006 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 749927022007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927022008 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927022009 active site 749927022010 catalytic tetrad [active] 749927022011 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 749927022012 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927022013 FAD binding domain; Region: FAD_binding_4; pfam01565 749927022014 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 749927022015 hypothetical protein; Validated; Region: PRK07586 749927022016 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749927022017 PYR/PP interface [polypeptide binding]; other site 749927022018 dimer interface [polypeptide binding]; other site 749927022019 TPP binding site [chemical binding]; other site 749927022020 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 749927022021 TPP-binding site [chemical binding]; other site 749927022022 dimer interface [polypeptide binding]; other site 749927022023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927022024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927022025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927022026 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927022027 putative substrate translocation pore; other site 749927022028 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 749927022029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 749927022030 Histidine kinase; Region: HisKA_3; pfam07730 749927022031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927022032 ATP binding site [chemical binding]; other site 749927022033 Mg2+ binding site [ion binding]; other site 749927022034 G-X-G motif; other site 749927022035 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927022036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927022037 active site 749927022038 phosphorylation site [posttranslational modification] 749927022039 intermolecular recognition site; other site 749927022040 dimerization interface [polypeptide binding]; other site 749927022041 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927022042 DNA binding residues [nucleotide binding] 749927022043 dimerization interface [polypeptide binding]; other site 749927022044 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 749927022045 MMPL family; Region: MMPL; cl14618 749927022046 MMPL family; Region: MMPL; cl14618 749927022047 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 749927022048 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 749927022049 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 749927022050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927022051 substrate binding site [chemical binding]; other site 749927022052 oxyanion hole (OAH) forming residues; other site 749927022053 trimer interface [polypeptide binding]; other site 749927022054 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927022055 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927022056 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 749927022057 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927022058 dimer interface [polypeptide binding]; other site 749927022059 active site 749927022060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927022061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927022062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927022063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927022064 HEXXH motif domain; Region: mod_HExxH; TIGR04267 749927022065 TPR repeat; Region: TPR_11; pfam13414 749927022066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927022067 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927022068 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927022069 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927022070 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927022071 Tetratricopeptide repeat; Region: TPR_10; pfam13374 749927022072 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927022073 Tetratricopeptide repeat; Region: TPR_10; pfam13374 749927022074 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 749927022075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927022076 Walker A motif; other site 749927022077 ATP binding site [chemical binding]; other site 749927022078 Walker B motif; other site 749927022079 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 749927022080 metal binding site [ion binding]; metal-binding site 749927022081 nucleotidyl binding site; other site 749927022082 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 749927022083 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927022084 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927022085 active site 749927022086 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927022087 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927022088 active site 749927022089 putative transposase OrfB; Reviewed; Region: PHA02517 749927022090 HTH-like domain; Region: HTH_21; pfam13276 749927022091 Integrase core domain; Region: rve; pfam00665 749927022092 Integrase core domain; Region: rve_3; pfam13683 749927022093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 749927022094 Transposase; Region: HTH_Tnp_1; cl17663 749927022095 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927022096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927022097 non-specific DNA binding site [nucleotide binding]; other site 749927022098 salt bridge; other site 749927022099 sequence-specific DNA binding site [nucleotide binding]; other site 749927022100 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 749927022101 nudix motif; other site 749927022102 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927022103 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl19415 749927022104 short chain dehydrogenase; Provisional; Region: PRK07825 749927022105 classical (c) SDRs; Region: SDR_c; cd05233 749927022106 NAD(P) binding site [chemical binding]; other site 749927022107 active site 749927022108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927022109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927022110 Coenzyme A binding pocket [chemical binding]; other site 749927022111 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 749927022112 active site 749927022113 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 749927022114 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927022115 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927022116 active site 749927022117 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 749927022118 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 749927022119 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 749927022120 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 749927022121 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 749927022122 carboxyltransferase (CT) interaction site; other site 749927022123 biotinylation site [posttranslational modification]; other site 749927022124 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 749927022125 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 749927022126 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 749927022127 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 749927022128 active site 749927022129 catalytic triad [active] 749927022130 oxyanion hole [active] 749927022131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927022132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927022133 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 749927022134 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 749927022135 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 749927022136 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 749927022137 homodimer interface [polypeptide binding]; other site 749927022138 substrate-cofactor binding pocket; other site 749927022139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927022140 catalytic residue [active] 749927022141 hypothetical protein; Provisional; Region: PRK06126 749927022142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927022143 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 749927022144 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927022145 Transcriptional regulator PadR-like family; Region: PadR; cl17335 749927022146 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 749927022147 putative dimer interface [polypeptide binding]; other site 749927022148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927022149 S-adenosylmethionine binding site [chemical binding]; other site 749927022150 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 749927022151 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 749927022152 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 749927022153 active site 749927022154 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927022155 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927022156 NAD(P) binding site [chemical binding]; other site 749927022157 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 749927022158 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 749927022159 hexamer interface [polypeptide binding]; other site 749927022160 ligand binding site [chemical binding]; other site 749927022161 putative active site [active] 749927022162 NAD(P) binding site [chemical binding]; other site 749927022163 Acyltransferase family; Region: Acyl_transf_3; cl19154 749927022164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927022165 ATP binding site [chemical binding]; other site 749927022166 G-X-G motif; other site 749927022167 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927022168 dimerization interface [polypeptide binding]; other site 749927022169 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927022170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927022171 active site 749927022172 phosphorylation site [posttranslational modification] 749927022173 intermolecular recognition site; other site 749927022174 dimerization interface [polypeptide binding]; other site 749927022175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927022176 DNA binding site [nucleotide binding] 749927022177 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927022178 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 749927022179 Walker A/P-loop; other site 749927022180 ATP binding site [chemical binding]; other site 749927022181 Q-loop/lid; other site 749927022182 ABC transporter signature motif; other site 749927022183 Walker B; other site 749927022184 D-loop; other site 749927022185 H-loop/switch region; other site 749927022186 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927022187 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927022188 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927022189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927022190 Walker A/P-loop; other site 749927022191 ATP binding site [chemical binding]; other site 749927022192 Q-loop/lid; other site 749927022193 ABC transporter signature motif; other site 749927022194 Walker B; other site 749927022195 D-loop; other site 749927022196 H-loop/switch region; other site 749927022197 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927022198 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927022199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927022200 Walker A/P-loop; other site 749927022201 ATP binding site [chemical binding]; other site 749927022202 Q-loop/lid; other site 749927022203 ABC transporter signature motif; other site 749927022204 Walker B; other site 749927022205 D-loop; other site 749927022206 H-loop/switch region; other site 749927022207 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 749927022208 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 749927022209 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 749927022210 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 749927022211 TPP-binding site [chemical binding]; other site 749927022212 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 749927022213 dimer interface [polypeptide binding]; other site 749927022214 PYR/PP interface [polypeptide binding]; other site 749927022215 TPP binding site [chemical binding]; other site 749927022216 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927022217 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927022218 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927022219 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 749927022220 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 749927022221 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927022222 active site 749927022223 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 749927022224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927022225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927022226 putative substrate translocation pore; other site 749927022227 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927022228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927022229 Coenzyme A binding pocket [chemical binding]; other site 749927022230 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927022231 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927022232 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 749927022233 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927022234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927022235 dimer interface [polypeptide binding]; other site 749927022236 conserved gate region; other site 749927022237 putative PBP binding loops; other site 749927022238 ABC-ATPase subunit interface; other site 749927022239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927022240 dimer interface [polypeptide binding]; other site 749927022241 conserved gate region; other site 749927022242 putative PBP binding loops; other site 749927022243 ABC-ATPase subunit interface; other site 749927022244 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 749927022245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927022246 Walker A/P-loop; other site 749927022247 ATP binding site [chemical binding]; other site 749927022248 Q-loop/lid; other site 749927022249 ABC transporter signature motif; other site 749927022250 Walker B; other site 749927022251 D-loop; other site 749927022252 H-loop/switch region; other site 749927022253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927022254 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 749927022255 Malic enzyme, N-terminal domain; Region: malic; pfam00390 749927022256 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 749927022257 putative NAD(P) binding site [chemical binding]; other site 749927022258 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 749927022259 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 749927022260 hydrophobic ligand binding site; other site 749927022261 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927022262 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927022263 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 749927022264 CoenzymeA binding site [chemical binding]; other site 749927022265 subunit interaction site [polypeptide binding]; other site 749927022266 PHB binding site; other site 749927022267 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927022268 catalytic core [active] 749927022269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927022270 Coenzyme A binding pocket [chemical binding]; other site 749927022271 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 749927022272 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 749927022273 Transcription factor WhiB; Region: Whib; pfam02467 749927022274 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 749927022275 PAS fold; Region: PAS_4; pfam08448 749927022276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 749927022277 Histidine kinase; Region: HisKA_2; pfam07568 749927022278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927022279 ATP binding site [chemical binding]; other site 749927022280 Mg2+ binding site [ion binding]; other site 749927022281 G-X-G motif; other site 749927022282 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 749927022283 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 749927022284 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927022285 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927022286 DNA binding residues [nucleotide binding] 749927022287 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 749927022288 putative deacylase active site [active] 749927022289 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927022290 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 749927022291 Uncharacterized conserved protein [Function unknown]; Region: COG2135 749927022292 Predicted GTPases [General function prediction only]; Region: COG1162 749927022293 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 749927022294 GTPase/Zn-binding domain interface [polypeptide binding]; other site 749927022295 GTP/Mg2+ binding site [chemical binding]; other site 749927022296 G4 box; other site 749927022297 G5 box; other site 749927022298 G1 box; other site 749927022299 Switch I region; other site 749927022300 G2 box; other site 749927022301 G3 box; other site 749927022302 Switch II region; other site 749927022303 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 749927022304 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 749927022305 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 749927022306 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 749927022307 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 749927022308 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 749927022309 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 749927022310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927022311 active site 749927022312 motif I; other site 749927022313 motif II; other site 749927022314 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927022315 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 749927022316 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 749927022317 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 749927022318 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 749927022319 30S subunit binding site; other site 749927022320 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 749927022321 lipoprotein LpqB; Provisional; Region: PRK13616 749927022322 Sporulation and spore germination; Region: Germane; pfam10646 749927022323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927022324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927022325 dimerization interface [polypeptide binding]; other site 749927022326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927022327 dimer interface [polypeptide binding]; other site 749927022328 phosphorylation site [posttranslational modification] 749927022329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927022330 ATP binding site [chemical binding]; other site 749927022331 Mg2+ binding site [ion binding]; other site 749927022332 G-X-G motif; other site 749927022333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927022334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927022335 active site 749927022336 phosphorylation site [posttranslational modification] 749927022337 intermolecular recognition site; other site 749927022338 dimerization interface [polypeptide binding]; other site 749927022339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927022340 DNA binding site [nucleotide binding] 749927022341 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 749927022342 [2Fe-2S] cluster binding site [ion binding]; other site 749927022343 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927022344 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927022345 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927022346 Predicted transcriptional regulator [Transcription]; Region: COG2378 749927022347 HTH domain; Region: HTH_11; pfam08279 749927022348 WYL domain; Region: WYL; pfam13280 749927022349 FAD dependent oxidoreductase; Region: DAO; pfam01266 749927022350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927022351 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927022352 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 749927022353 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 749927022354 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 749927022355 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 749927022356 thymidylate kinase; Validated; Region: PRK07933 749927022357 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 749927022358 putative active site [active] 749927022359 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 749927022360 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 749927022361 putative active site [active] 749927022362 HicB family; Region: HicB; pfam05534 749927022363 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 749927022364 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 749927022365 homotetramer interface [polypeptide binding]; other site 749927022366 ligand binding site [chemical binding]; other site 749927022367 catalytic site [active] 749927022368 NAD binding site [chemical binding]; other site 749927022369 amino acid transporter; Region: 2A0306; TIGR00909 749927022370 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927022371 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 749927022372 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 749927022373 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927022374 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927022375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927022376 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 749927022377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927022378 TPR motif; other site 749927022379 binding surface 749927022380 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 749927022381 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 749927022382 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 749927022383 Trm112p-like protein; Region: Trm112p; cl01066 749927022384 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 749927022385 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 749927022386 active site 749927022387 substrate binding site [chemical binding]; other site 749927022388 metal binding site [ion binding]; metal-binding site 749927022389 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 749927022390 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 749927022391 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 749927022392 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927022393 active site 749927022394 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927022395 Transcription factor WhiB; Region: Whib; pfam02467 749927022396 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 749927022397 Peptidase family M50; Region: Peptidase_M50; pfam02163 749927022398 active site 749927022399 putative substrate binding region [chemical binding]; other site 749927022400 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 749927022401 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 749927022402 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927022403 Walker A/P-loop; other site 749927022404 ATP binding site [chemical binding]; other site 749927022405 Q-loop/lid; other site 749927022406 ABC transporter signature motif; other site 749927022407 Walker B; other site 749927022408 D-loop; other site 749927022409 H-loop/switch region; other site 749927022410 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927022411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927022412 Walker A/P-loop; other site 749927022413 ATP binding site [chemical binding]; other site 749927022414 Q-loop/lid; other site 749927022415 ABC transporter signature motif; other site 749927022416 Walker B; other site 749927022417 D-loop; other site 749927022418 H-loop/switch region; other site 749927022419 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927022420 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 749927022421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927022422 dimer interface [polypeptide binding]; other site 749927022423 conserved gate region; other site 749927022424 putative PBP binding loops; other site 749927022425 ABC-ATPase subunit interface; other site 749927022426 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 749927022427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927022428 dimer interface [polypeptide binding]; other site 749927022429 conserved gate region; other site 749927022430 putative PBP binding loops; other site 749927022431 ABC-ATPase subunit interface; other site 749927022432 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 749927022433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927022434 dimer interface [polypeptide binding]; other site 749927022435 conserved gate region; other site 749927022436 putative PBP binding loops; other site 749927022437 ABC-ATPase subunit interface; other site 749927022438 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 749927022439 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 749927022440 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 749927022441 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 749927022442 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 749927022443 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 749927022444 G1 box; other site 749927022445 putative GEF interaction site [polypeptide binding]; other site 749927022446 GTP/Mg2+ binding site [chemical binding]; other site 749927022447 Switch I region; other site 749927022448 G2 box; other site 749927022449 G3 box; other site 749927022450 Switch II region; other site 749927022451 G4 box; other site 749927022452 G5 box; other site 749927022453 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 749927022454 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 749927022455 YCII-related domain; Region: YCII; cl00999 749927022456 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 749927022457 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 749927022458 active site 749927022459 HIGH motif; other site 749927022460 dimer interface [polypeptide binding]; other site 749927022461 KMSKS motif; other site 749927022462 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 749927022463 nudix motif; other site 749927022464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927022465 HAMP domain; Region: HAMP; pfam00672 749927022466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927022467 dimer interface [polypeptide binding]; other site 749927022468 phosphorylation site [posttranslational modification] 749927022469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927022470 ATP binding site [chemical binding]; other site 749927022471 Mg2+ binding site [ion binding]; other site 749927022472 G-X-G motif; other site 749927022473 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927022474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927022475 active site 749927022476 phosphorylation site [posttranslational modification] 749927022477 intermolecular recognition site; other site 749927022478 dimerization interface [polypeptide binding]; other site 749927022479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927022480 DNA binding site [nucleotide binding] 749927022481 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 749927022482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927022483 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927022484 Walker A/P-loop; other site 749927022485 ATP binding site [chemical binding]; other site 749927022486 Q-loop/lid; other site 749927022487 ABC transporter signature motif; other site 749927022488 Walker B; other site 749927022489 D-loop; other site 749927022490 H-loop/switch region; other site 749927022491 Acyltransferase family; Region: Acyl_transf_3; cl19154 749927022492 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 749927022493 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 749927022494 Walker A/P-loop; other site 749927022495 ATP binding site [chemical binding]; other site 749927022496 Q-loop/lid; other site 749927022497 ABC transporter signature motif; other site 749927022498 Walker B; other site 749927022499 D-loop; other site 749927022500 H-loop/switch region; other site 749927022501 TOBE domain; Region: TOBE_2; pfam08402 749927022502 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 749927022503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927022504 dimer interface [polypeptide binding]; other site 749927022505 conserved gate region; other site 749927022506 putative PBP binding loops; other site 749927022507 ABC-ATPase subunit interface; other site 749927022508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927022509 dimer interface [polypeptide binding]; other site 749927022510 conserved gate region; other site 749927022511 putative PBP binding loops; other site 749927022512 ABC-ATPase subunit interface; other site 749927022513 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 749927022514 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 749927022515 aromatic arch; other site 749927022516 DCoH dimer interaction site [polypeptide binding]; other site 749927022517 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 749927022518 DCoH tetramer interaction site [polypeptide binding]; other site 749927022519 substrate binding site [chemical binding]; other site 749927022520 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 749927022521 SOUL heme-binding protein; Region: SOUL; pfam04832 749927022522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927022523 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927022524 putative DNA binding site [nucleotide binding]; other site 749927022525 putative Zn2+ binding site [ion binding]; other site 749927022526 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 749927022527 active site 749927022528 NTP binding site [chemical binding]; other site 749927022529 metal binding triad [ion binding]; metal-binding site 749927022530 antibiotic binding site [chemical binding]; other site 749927022531 GTP-binding protein YchF; Reviewed; Region: PRK09601 749927022532 YchF GTPase; Region: YchF; cd01900 749927022533 G1 box; other site 749927022534 GTP/Mg2+ binding site [chemical binding]; other site 749927022535 Switch I region; other site 749927022536 G2 box; other site 749927022537 Switch II region; other site 749927022538 G3 box; other site 749927022539 G4 box; other site 749927022540 G5 box; other site 749927022541 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 749927022542 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 749927022543 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 749927022544 AlkA N-terminal domain; Region: AlkA_N; pfam06029 749927022545 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 749927022546 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 749927022547 helix-hairpin-helix signature motif; other site 749927022548 substrate binding pocket [chemical binding]; other site 749927022549 active site 749927022550 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 749927022551 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 749927022552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927022553 Walker A/P-loop; other site 749927022554 ATP binding site [chemical binding]; other site 749927022555 Q-loop/lid; other site 749927022556 ABC transporter signature motif; other site 749927022557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927022558 ABC transporter signature motif; other site 749927022559 Walker B; other site 749927022560 D-loop; other site 749927022561 H-loop/switch region; other site 749927022562 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 749927022563 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 749927022564 active site 749927022565 metal binding site [ion binding]; metal-binding site 749927022566 DNA binding site [nucleotide binding] 749927022567 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 749927022568 RmuC family; Region: RmuC; pfam02646 749927022569 TraH_2; Region: TraH_2; cl17600 749927022570 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 749927022571 Fe-S cluster binding site [ion binding]; other site 749927022572 substrate binding site [chemical binding]; other site 749927022573 catalytic site [active] 749927022574 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 749927022575 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 749927022576 generic binding surface II; other site 749927022577 generic binding surface I; other site 749927022578 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927022579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927022580 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 749927022581 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 749927022582 putative active site [active] 749927022583 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 749927022584 Trypsin-like serine protease; Region: Tryp_SPc; smart00020 749927022585 active site 749927022586 substrate binding sites [chemical binding]; other site 749927022587 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 749927022588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927022589 fumarate hydratase; Reviewed; Region: fumC; PRK00485 749927022590 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 749927022591 tetramer interface [polypeptide binding]; other site 749927022592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927022593 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927022594 salt bridge; other site 749927022595 non-specific DNA binding site [nucleotide binding]; other site 749927022596 sequence-specific DNA binding site [nucleotide binding]; other site 749927022597 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 749927022598 DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675 749927022599 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 749927022600 active site 749927022601 DNA binding site [nucleotide binding] 749927022602 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 749927022603 DNA binding site [nucleotide binding] 749927022604 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927022605 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 749927022606 Domain of unknown function (DUF309); Region: DUF309; pfam03745 749927022607 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 749927022608 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 749927022609 active site 749927022610 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 749927022611 potential frameshift: common BLAST hit: gi|284030771|ref|YP_003380702.1| WD40 domain protein beta Propeller 749927022612 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927022613 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 749927022614 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 749927022615 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 749927022616 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 749927022617 structural tetrad; other site 749927022618 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 749927022619 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927022620 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927022621 Amidohydrolase; Region: Amidohydro_4; pfam13147 749927022622 active site 749927022623 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 749927022624 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 749927022625 putative active site [active] 749927022626 PhoH-like protein; Region: PhoH; pfam02562 749927022627 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 749927022628 active site 749927022629 dimer interface [polypeptide binding]; other site 749927022630 Haemolysin-III related; Region: HlyIII; cl03831 749927022631 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 749927022632 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927022633 PRC-barrel domain; Region: PRC; pfam05239 749927022634 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 749927022635 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927022636 acyl-coenzyme A oxidase; Region: PLN02636 749927022637 active site 749927022638 TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518 749927022639 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 749927022640 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 749927022641 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 749927022642 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 749927022643 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 749927022644 catalytic residues [active] 749927022645 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 749927022646 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 749927022647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927022648 S-adenosylmethionine binding site [chemical binding]; other site 749927022649 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 749927022650 AAA domain; Region: AAA_17; cl19128 749927022651 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927022652 active site 749927022653 metal binding site [ion binding]; metal-binding site 749927022654 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 749927022655 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 749927022656 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 749927022657 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 749927022658 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 749927022659 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927022660 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927022661 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927022662 AsnC family; Region: AsnC_trans_reg; pfam01037 749927022663 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 749927022664 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 749927022665 dimer interface [polypeptide binding]; other site 749927022666 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 749927022667 active site 749927022668 Fe binding site [ion binding]; other site 749927022669 Family of unknown function (DUF566); Region: DUF566; pfam04484 749927022670 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 749927022671 threonine dehydratase; Provisional; Region: PRK08198 749927022672 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 749927022673 tetramer interface [polypeptide binding]; other site 749927022674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927022675 catalytic residue [active] 749927022676 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 749927022677 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927022678 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 749927022679 homodimer interface [polypeptide binding]; other site 749927022680 substrate-cofactor binding pocket; other site 749927022681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927022682 catalytic residue [active] 749927022683 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 749927022684 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 749927022685 dimer interface [polypeptide binding]; other site 749927022686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927022687 catalytic residue [active] 749927022688 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 749927022689 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 749927022690 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927022691 dimer interface [polypeptide binding]; other site 749927022692 active site 749927022693 Bax inhibitor 1 like; Region: BaxI_1; cl17691 749927022694 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 749927022695 ATP binding site [chemical binding]; other site 749927022696 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 749927022697 active site 749927022698 putative catalytic site [active] 749927022699 short chain dehydrogenase; Provisional; Region: PRK07201 749927022700 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 749927022701 putative NAD(P) binding site [chemical binding]; other site 749927022702 active site 749927022703 putative substrate binding site [chemical binding]; other site 749927022704 classical (c) SDRs; Region: SDR_c; cd05233 749927022705 NAD(P) binding site [chemical binding]; other site 749927022706 active site 749927022707 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 749927022708 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 749927022709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927022710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927022711 DNA binding residues [nucleotide binding] 749927022712 dimerization interface [polypeptide binding]; other site 749927022713 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 749927022714 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927022715 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927022716 DNA binding site [nucleotide binding] 749927022717 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927022718 AAA ATPase domain; Region: AAA_16; pfam13191 749927022719 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927022720 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927022721 DNA binding site [nucleotide binding] 749927022722 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927022723 AAA ATPase domain; Region: AAA_16; pfam13191 749927022724 Predicted ATPase [General function prediction only]; Region: COG3899 749927022725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927022726 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927022727 DNA binding residues [nucleotide binding] 749927022728 dimerization interface [polypeptide binding]; other site 749927022729 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 749927022730 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 749927022731 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927022732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927022733 dimer interface [polypeptide binding]; other site 749927022734 conserved gate region; other site 749927022735 putative PBP binding loops; other site 749927022736 ABC-ATPase subunit interface; other site 749927022737 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927022738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927022739 dimer interface [polypeptide binding]; other site 749927022740 putative PBP binding loops; other site 749927022741 ABC-ATPase subunit interface; other site 749927022742 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927022743 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927022744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927022745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927022746 DNA binding residues [nucleotide binding] 749927022747 dimerization interface [polypeptide binding]; other site 749927022748 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 749927022749 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927022750 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927022751 active site 749927022752 catalytic tetrad [active] 749927022753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927022754 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927022755 putative substrate translocation pore; other site 749927022756 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927022757 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 749927022758 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927022759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927022760 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 749927022761 aromatic chitin/cellulose binding site residues [chemical binding]; other site 749927022762 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 749927022763 aromatic chitin/cellulose binding site residues [chemical binding]; other site 749927022764 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 749927022765 putative sugar binding site [chemical binding]; other site 749927022766 catalytic residues [active] 749927022767 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 749927022768 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927022769 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 749927022770 active site 749927022771 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 749927022772 Cupin; Region: Cupin_6; pfam12852 749927022773 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 749927022774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927022775 TQXA domain; Region: TQXA_dom; TIGR03934 749927022776 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 749927022777 Cellulose binding domain; Region: CBM_2; pfam00553 749927022778 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 749927022779 elongation factor G; Reviewed; Region: PRK13351 749927022780 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749927022781 G1 box; other site 749927022782 GTP/Mg2+ binding site [chemical binding]; other site 749927022783 G2 box; other site 749927022784 Switch I region; other site 749927022785 G3 box; other site 749927022786 Switch II region; other site 749927022787 G4 box; other site 749927022788 G5 box; other site 749927022789 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 749927022790 Elongation Factor G, domain II; Region: EFG_II; pfam14492 749927022791 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 749927022792 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 749927022793 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 749927022794 Phosphotransferase enzyme family; Region: APH; pfam01636 749927022795 putative active site [active] 749927022796 putative substrate binding site [chemical binding]; other site 749927022797 ATP binding site [chemical binding]; other site 749927022798 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927022799 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927022800 dimerization interface [polypeptide binding]; other site 749927022801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927022802 dimer interface [polypeptide binding]; other site 749927022803 phosphorylation site [posttranslational modification] 749927022804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927022805 ATP binding site [chemical binding]; other site 749927022806 Mg2+ binding site [ion binding]; other site 749927022807 G-X-G motif; other site 749927022808 enolase; Provisional; Region: eno; PRK00077 749927022809 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 749927022810 dimer interface [polypeptide binding]; other site 749927022811 metal binding site [ion binding]; metal-binding site 749927022812 substrate binding pocket [chemical binding]; other site 749927022813 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 749927022814 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 749927022815 Catalytic site [active] 749927022816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927022817 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 749927022818 Walker A/P-loop; other site 749927022819 ATP binding site [chemical binding]; other site 749927022820 Q-loop/lid; other site 749927022821 ABC transporter signature motif; other site 749927022822 Walker B; other site 749927022823 D-loop; other site 749927022824 H-loop/switch region; other site 749927022825 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749927022826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927022827 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927022828 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927022829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927022830 binding surface 749927022831 TPR motif; other site 749927022832 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927022833 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 749927022834 active site 749927022835 catalytic triad [active] 749927022836 oxyanion hole [active] 749927022837 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 749927022838 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927022839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927022840 hypothetical protein; Provisional; Region: PRK06834 749927022841 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927022842 AAA ATPase domain; Region: AAA_16; pfam13191 749927022843 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927022844 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927022845 DNA binding residues [nucleotide binding] 749927022846 dimerization interface [polypeptide binding]; other site 749927022847 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 749927022848 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 749927022849 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 749927022850 AAA domain; Region: AAA_22; pfam13401 749927022851 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 749927022852 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 749927022853 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927022854 TIR domain; Region: TIR_2; cl17458 749927022855 AAA ATPase domain; Region: AAA_16; pfam13191 749927022856 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927022857 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 749927022858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927022859 FeS/SAM binding site; other site 749927022860 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 749927022861 HEXXH motif domain; Region: mod_HExxH; TIGR04267 749927022862 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927022863 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927022864 DNA binding residues [nucleotide binding] 749927022865 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927022866 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927022867 active site 749927022868 ATP binding site [chemical binding]; other site 749927022869 substrate binding site [chemical binding]; other site 749927022870 activation loop (A-loop); other site 749927022871 PemK-like protein; Region: PemK; cl00995 749927022872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927022873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927022874 putative substrate translocation pore; other site 749927022875 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927022876 Probable pheophorbidase; Region: PLN02965; cl17657 749927022877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927022878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927022879 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927022880 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927022881 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927022882 DNA binding residues [nucleotide binding] 749927022883 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 749927022884 active site 749927022885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927022886 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927022887 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927022888 Cupin domain; Region: Cupin_2; cl17218 749927022889 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 749927022890 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 749927022891 nudix motif; other site 749927022892 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 749927022893 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 749927022894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927022895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927022896 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 749927022897 Fe-S cluster binding site [ion binding]; other site 749927022898 DNA binding site [nucleotide binding] 749927022899 active site 749927022900 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 749927022901 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 749927022902 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 749927022903 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927022904 Subtilase family; Region: Peptidase_S8; pfam00082 749927022905 active site 749927022906 catalytic residues [active] 749927022907 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927022908 catalytic residues [active] 749927022909 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 749927022910 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927022911 Walker A/P-loop; other site 749927022912 ATP binding site [chemical binding]; other site 749927022913 Q-loop/lid; other site 749927022914 ABC transporter signature motif; other site 749927022915 Walker B; other site 749927022916 D-loop; other site 749927022917 H-loop/switch region; other site 749927022918 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927022919 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 749927022920 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927022921 Walker A/P-loop; other site 749927022922 ATP binding site [chemical binding]; other site 749927022923 Q-loop/lid; other site 749927022924 ABC transporter signature motif; other site 749927022925 Walker B; other site 749927022926 D-loop; other site 749927022927 H-loop/switch region; other site 749927022928 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927022929 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 749927022930 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 749927022931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927022932 dimer interface [polypeptide binding]; other site 749927022933 conserved gate region; other site 749927022934 putative PBP binding loops; other site 749927022935 ABC-ATPase subunit interface; other site 749927022936 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 749927022937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927022938 dimer interface [polypeptide binding]; other site 749927022939 conserved gate region; other site 749927022940 putative PBP binding loops; other site 749927022941 ABC-ATPase subunit interface; other site 749927022942 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 749927022943 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 749927022944 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 749927022945 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 749927022946 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 749927022947 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749927022948 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749927022949 Uncharacterized conserved protein [Function unknown]; Region: COG1507 749927022950 Septum formation initiator; Region: DivIC; cl17659 749927022951 enolase; Provisional; Region: eno; PRK00077 749927022952 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 749927022953 dimer interface [polypeptide binding]; other site 749927022954 metal binding site [ion binding]; metal-binding site 749927022955 substrate binding pocket [chemical binding]; other site 749927022956 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 749927022957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927022958 binding surface 749927022959 TPR motif; other site 749927022960 TPR repeat; Region: TPR_11; pfam13414 749927022961 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 749927022962 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749927022963 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749927022964 Iron permease FTR1 family; Region: FTR1; cl00475 749927022965 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 749927022966 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 749927022967 Imelysin; Region: Peptidase_M75; pfam09375 749927022968 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 749927022969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927022970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927022971 WHG domain; Region: WHG; pfam13305 749927022972 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 749927022973 active site 749927022974 catalytic triad [active] 749927022975 oxyanion hole [active] 749927022976 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 749927022977 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 749927022978 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 749927022979 Walker A/P-loop; other site 749927022980 ATP binding site [chemical binding]; other site 749927022981 Q-loop/lid; other site 749927022982 ABC transporter signature motif; other site 749927022983 Walker B; other site 749927022984 D-loop; other site 749927022985 H-loop/switch region; other site 749927022986 Putative zinc-finger; Region: zf-HC2; pfam13490 749927022987 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927022988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927022989 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927022990 DNA binding residues [nucleotide binding] 749927022991 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 749927022992 homodimer interface [polypeptide binding]; other site 749927022993 MazG family protein; Region: mazG; TIGR00444 749927022994 metal binding site [ion binding]; metal-binding site 749927022995 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 749927022996 SurA N-terminal domain; Region: SurA_N_3; cl07813 749927022997 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 749927022998 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 749927022999 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 749927023000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927023001 ATP binding site [chemical binding]; other site 749927023002 putative Mg++ binding site [ion binding]; other site 749927023003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927023004 nucleotide binding region [chemical binding]; other site 749927023005 ATP-binding site [chemical binding]; other site 749927023006 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 749927023007 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927023008 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927023009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927023010 non-specific DNA binding site [nucleotide binding]; other site 749927023011 salt bridge; other site 749927023012 sequence-specific DNA binding site [nucleotide binding]; other site 749927023013 Putative rep protein (DUF1424); Region: DUF1424; pfam07232 749927023014 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 749927023015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927023016 S-adenosylmethionine binding site [chemical binding]; other site 749927023017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927023018 Histidine kinase; Region: HisKA_3; pfam07730 749927023019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927023020 ATP binding site [chemical binding]; other site 749927023021 Mg2+ binding site [ion binding]; other site 749927023022 G-X-G motif; other site 749927023023 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927023024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927023025 active site 749927023026 phosphorylation site [posttranslational modification] 749927023027 intermolecular recognition site; other site 749927023028 dimerization interface [polypeptide binding]; other site 749927023029 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927023030 DNA binding residues [nucleotide binding] 749927023031 dimerization interface [polypeptide binding]; other site 749927023032 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 749927023033 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 749927023034 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 749927023035 classical (c) SDRs; Region: SDR_c; cd05233 749927023036 NAD(P) binding site [chemical binding]; other site 749927023037 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 749927023038 active site 749927023039 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 749927023040 catalytic triad [active] 749927023041 conserved cis-peptide bond; other site 749927023042 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 749927023043 nudix motif; other site 749927023044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927023045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927023046 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 749927023047 Di-iron ligands [ion binding]; other site 749927023048 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927023049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927023050 metal binding site [ion binding]; metal-binding site 749927023051 active site 749927023052 I-site; other site 749927023053 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 749927023054 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 749927023055 Substrate binding site; other site 749927023056 Mg++ binding site; other site 749927023057 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 749927023058 active site 749927023059 substrate binding site [chemical binding]; other site 749927023060 CoA binding site [chemical binding]; other site 749927023061 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 749927023062 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 749927023063 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927023064 active site 749927023065 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927023066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927023067 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927023068 NAD(P) binding site [chemical binding]; other site 749927023069 active site 749927023070 Predicted oxidoreductase [General function prediction only]; Region: COG3573 749927023071 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 749927023072 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 749927023073 5S rRNA interface [nucleotide binding]; other site 749927023074 CTC domain interface [polypeptide binding]; other site 749927023075 L16 interface [polypeptide binding]; other site 749927023076 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 749927023077 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 749927023078 putative active site [active] 749927023079 catalytic residue [active] 749927023080 DivIVA domain; Region: DivI1A_domain; TIGR03544 749927023081 DivIVA domain; Region: DivI1A_domain; TIGR03544 749927023082 DivIVA domain; Region: DivI1A_domain; TIGR03544 749927023083 DivIVA domain; Region: DivI1A_domain; TIGR03544 749927023084 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 749927023085 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927023086 acyl-activating enzyme (AAE) consensus motif; other site 749927023087 AMP binding site [chemical binding]; other site 749927023088 active site 749927023089 CoA binding site [chemical binding]; other site 749927023090 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 749927023091 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749927023092 ABC transporter; Region: ABC_tran_2; pfam12848 749927023093 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 749927023094 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 749927023095 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 749927023096 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 749927023097 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 749927023098 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 749927023099 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 749927023100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927023101 Walker A/P-loop; other site 749927023102 ATP binding site [chemical binding]; other site 749927023103 Q-loop/lid; other site 749927023104 ABC transporter signature motif; other site 749927023105 Walker B; other site 749927023106 D-loop; other site 749927023107 H-loop/switch region; other site 749927023108 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 749927023109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927023110 Domain of unknown function (DUF348); Region: DUF348; pfam03990 749927023111 G5 domain; Region: G5; pfam07501 749927023112 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 749927023113 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 749927023114 active site 749927023115 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 749927023116 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 749927023117 active site 749927023118 HIGH motif; other site 749927023119 KMSKS motif; other site 749927023120 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 749927023121 tRNA binding surface [nucleotide binding]; other site 749927023122 anticodon binding site; other site 749927023123 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927023124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927023125 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 749927023126 Walker A/P-loop; other site 749927023127 ATP binding site [chemical binding]; other site 749927023128 Q-loop/lid; other site 749927023129 ABC transporter signature motif; other site 749927023130 Walker B; other site 749927023131 D-loop; other site 749927023132 H-loop/switch region; other site 749927023133 ABC-2 type transporter; Region: ABC2_membrane; cl17235 749927023134 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 749927023135 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 749927023136 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 749927023137 active site 749927023138 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 749927023139 chorismate binding enzyme; Region: Chorismate_bind; cl10555 749927023140 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927023141 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927023142 NAD(P) binding site [chemical binding]; other site 749927023143 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 749927023144 putative SAM binding site [chemical binding]; other site 749927023145 putative homodimer interface [polypeptide binding]; other site 749927023146 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 749927023147 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 749927023148 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 749927023149 Helix-turn-helix domain; Region: HTH_18; pfam12833 749927023150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927023151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927023152 S-adenosylmethionine binding site [chemical binding]; other site 749927023153 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927023154 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927023155 active site 749927023156 ATP binding site [chemical binding]; other site 749927023157 substrate binding site [chemical binding]; other site 749927023158 activation loop (A-loop); other site 749927023159 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 749927023160 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 749927023161 acyl-activating enzyme (AAE) consensus motif; other site 749927023162 putative AMP binding site [chemical binding]; other site 749927023163 putative active site [active] 749927023164 putative CoA binding site [chemical binding]; other site 749927023165 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 749927023166 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 749927023167 active site 749927023168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927023169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 749927023170 MOSC domain; Region: MOSC; pfam03473 749927023171 hypothetical protein; Provisional; Region: PRK07079 749927023172 hypothetical protein; Provisional; Region: PRK08201 749927023173 metal binding site [ion binding]; metal-binding site 749927023174 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 749927023175 SnoaL-like domain; Region: SnoaL_3; pfam13474 749927023176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927023177 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 749927023178 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927023179 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 749927023180 active site 749927023181 catalytic triad [active] 749927023182 oxyanion hole [active] 749927023183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927023184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927023185 WHG domain; Region: WHG; pfam13305 749927023186 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 749927023187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927023188 putative DNA binding site [nucleotide binding]; other site 749927023189 dimerization interface [polypeptide binding]; other site 749927023190 putative Zn2+ binding site [ion binding]; other site 749927023191 MMPL family; Region: MMPL; cl14618 749927023192 MMPL family; Region: MMPL; cl14618 749927023193 PAS domain S-box; Region: sensory_box; TIGR00229 749927023194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 749927023195 putative active site [active] 749927023196 heme pocket [chemical binding]; other site 749927023197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927023198 metal binding site [ion binding]; metal-binding site 749927023199 active site 749927023200 I-site; other site 749927023201 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 749927023202 Cytochrome P450; Region: p450; pfam00067 749927023203 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 749927023204 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 749927023205 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927023206 P-loop; other site 749927023207 Magnesium ion binding site [ion binding]; other site 749927023208 Nuclear pore protein 84 / 107; Region: Nup84_Nup100; pfam04121 749927023209 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 749927023210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927023211 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927023212 NAD(P) binding site [chemical binding]; other site 749927023213 active site 749927023214 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 749927023215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927023216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927023217 active site 749927023218 phosphorylation site [posttranslational modification] 749927023219 intermolecular recognition site; other site 749927023220 dimerization interface [polypeptide binding]; other site 749927023221 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927023222 DNA binding site [nucleotide binding] 749927023223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927023224 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927023225 dimerization interface [polypeptide binding]; other site 749927023226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927023227 dimer interface [polypeptide binding]; other site 749927023228 phosphorylation site [posttranslational modification] 749927023229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927023230 ATP binding site [chemical binding]; other site 749927023231 Mg2+ binding site [ion binding]; other site 749927023232 G-X-G motif; other site 749927023233 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 749927023234 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 749927023235 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 749927023236 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 749927023237 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 749927023238 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 749927023239 putative ligand binding site [chemical binding]; other site 749927023240 putative NAD binding site [chemical binding]; other site 749927023241 catalytic site [active] 749927023242 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 749927023243 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927023244 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927023245 SCP-2 sterol transfer family; Region: SCP2; cl01225 749927023246 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 749927023247 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927023248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927023249 homodimer interface [polypeptide binding]; other site 749927023250 catalytic residue [active] 749927023251 Condensation domain; Region: Condensation; cl19241 749927023252 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 749927023253 Nonribosomal peptide synthase; Region: NRPS; pfam08415 749927023254 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 749927023255 acyl-activating enzyme (AAE) consensus motif; other site 749927023256 AMP binding site [chemical binding]; other site 749927023257 Methyltransferase domain; Region: Methyltransf_31; pfam13847 749927023258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927023259 S-adenosylmethionine binding site [chemical binding]; other site 749927023260 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927023261 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 749927023262 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 749927023263 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 749927023264 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927023265 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 749927023266 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 749927023267 DNA-binding interface [nucleotide binding]; DNA binding site 749927023268 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927023269 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927023270 active site 749927023271 ATP binding site [chemical binding]; other site 749927023272 substrate binding site [chemical binding]; other site 749927023273 activation loop (A-loop); other site 749927023274 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 749927023275 AIPR protein; Region: AIPR; pfam10592 749927023276 AAA ATPase domain; Region: AAA_16; pfam13191 749927023277 Domain of unknown function DUF87; Region: DUF87; cl19135 749927023278 AAA-like domain; Region: AAA_10; pfam12846 749927023279 Zonular occludens toxin (Zot); Region: Zot; cl17485 749927023280 DEAD-like helicases superfamily; Region: DEXDc; smart00487 749927023281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927023282 ATP binding site [chemical binding]; other site 749927023283 putative Mg++ binding site [ion binding]; other site 749927023284 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 749927023285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927023286 ATP-binding site [chemical binding]; other site 749927023287 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 749927023288 Neural proliferation differentiation control-1 protein (NPDC1); Region: NPDC1; pfam06809 749927023289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927023290 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 749927023291 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 749927023292 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 749927023293 dimer interface [polypeptide binding]; other site 749927023294 putative functional site; other site 749927023295 putative MPT binding site; other site 749927023296 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 749927023297 active site 749927023298 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 749927023299 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 749927023300 Protein of unknown function (DUF2895); Region: DUF2895; cl12968 749927023301 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 749927023302 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 749927023303 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 749927023304 MPT binding site; other site 749927023305 trimer interface [polypeptide binding]; other site 749927023306 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 749927023307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927023308 NAD(P) binding site [chemical binding]; other site 749927023309 active site 749927023310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 749927023311 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 749927023312 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927023313 dimer interface [polypeptide binding]; other site 749927023314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927023315 phosphorylation site [posttranslational modification] 749927023316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927023317 ATP binding site [chemical binding]; other site 749927023318 Mg2+ binding site [ion binding]; other site 749927023319 G-X-G motif; other site 749927023320 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927023321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927023322 active site 749927023323 phosphorylation site [posttranslational modification] 749927023324 intermolecular recognition site; other site 749927023325 dimerization interface [polypeptide binding]; other site 749927023326 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927023327 DNA binding site [nucleotide binding] 749927023328 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 749927023329 Ligand binding site; other site 749927023330 Putative Catalytic site; other site 749927023331 DXD motif; other site 749927023332 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 749927023333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927023334 S-adenosylmethionine binding site [chemical binding]; other site 749927023335 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 749927023336 Moco binding site; other site 749927023337 metal coordination site [ion binding]; other site 749927023338 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 749927023339 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 749927023340 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927023341 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 749927023342 protein binding site [polypeptide binding]; other site 749927023343 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 749927023344 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 749927023345 dimer interface [polypeptide binding]; other site 749927023346 active site 749927023347 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 749927023348 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 749927023349 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 749927023350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927023351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927023352 dimerization interface [polypeptide binding]; other site 749927023353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927023354 dimer interface [polypeptide binding]; other site 749927023355 phosphorylation site [posttranslational modification] 749927023356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927023357 ATP binding site [chemical binding]; other site 749927023358 Mg2+ binding site [ion binding]; other site 749927023359 G-X-G motif; other site 749927023360 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927023361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927023362 active site 749927023363 phosphorylation site [posttranslational modification] 749927023364 intermolecular recognition site; other site 749927023365 dimerization interface [polypeptide binding]; other site 749927023366 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927023367 DNA binding site [nucleotide binding] 749927023368 Predicted membrane protein [Function unknown]; Region: COG2860 749927023369 UPF0126 domain; Region: UPF0126; pfam03458 749927023370 UPF0126 domain; Region: UPF0126; pfam03458 749927023371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927023372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927023373 active site 749927023374 phosphorylation site [posttranslational modification] 749927023375 intermolecular recognition site; other site 749927023376 dimerization interface [polypeptide binding]; other site 749927023377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927023378 DNA binding residues [nucleotide binding] 749927023379 dimerization interface [polypeptide binding]; other site 749927023380 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 749927023381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927023382 S-adenosylmethionine binding site [chemical binding]; other site 749927023383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927023384 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927023385 putative substrate translocation pore; other site 749927023386 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927023387 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927023388 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 749927023389 dimerization interface [polypeptide binding]; other site 749927023390 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927023391 active site 749927023392 catalytic tetrad [active] 749927023393 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 749927023394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927023395 DNA-binding site [nucleotide binding]; DNA binding site 749927023396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927023397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927023398 homodimer interface [polypeptide binding]; other site 749927023399 catalytic residue [active] 749927023400 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 749927023401 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 749927023402 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927023403 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927023404 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 749927023405 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927023406 active site 749927023407 ATP binding site [chemical binding]; other site 749927023408 substrate binding site [chemical binding]; other site 749927023409 activation loop (A-loop); other site 749927023410 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 749927023411 active site 749927023412 dimerization interface [polypeptide binding]; other site 749927023413 Creatinine amidohydrolase; Region: Creatininase; pfam02633 749927023414 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 749927023415 dimerization interface [polypeptide binding]; other site 749927023416 active site 749927023417 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 749927023418 Methyltransferase domain; Region: Methyltransf_18; pfam12847 749927023419 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 749927023420 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 749927023421 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 749927023422 active site 749927023423 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 749927023424 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 749927023425 putative NAD(P) binding site [chemical binding]; other site 749927023426 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 749927023427 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 749927023428 nucleotide binding site [chemical binding]; other site 749927023429 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 749927023430 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 749927023431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927023432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927023433 dimerization interface [polypeptide binding]; other site 749927023434 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927023435 FAD binding domain; Region: FAD_binding_4; pfam01565 749927023436 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 749927023437 Domain of unknown function (DUF385); Region: DUF385; pfam04075 749927023438 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927023439 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927023440 putative Zn2+ binding site [ion binding]; other site 749927023441 putative DNA binding site [nucleotide binding]; other site 749927023442 Cytochrome P450; Region: p450; cl12078 749927023443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927023444 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927023445 PaaX-like protein; Region: PaaX; pfam07848 749927023446 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 749927023447 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 749927023448 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 749927023449 homotrimer interaction site [polypeptide binding]; other site 749927023450 putative active site [active] 749927023451 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 749927023452 hypothetical protein; Provisional; Region: PRK07236 749927023453 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 749927023454 active site 749927023455 FMN binding site [chemical binding]; other site 749927023456 substrate binding site [chemical binding]; other site 749927023457 homotetramer interface [polypeptide binding]; other site 749927023458 catalytic residue [active] 749927023459 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927023460 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927023461 active site 749927023462 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 749927023463 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 749927023464 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 749927023465 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 749927023466 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927023467 Walker A/P-loop; other site 749927023468 ATP binding site [chemical binding]; other site 749927023469 Q-loop/lid; other site 749927023470 ABC transporter signature motif; other site 749927023471 Walker B; other site 749927023472 D-loop; other site 749927023473 H-loop/switch region; other site 749927023474 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927023475 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 749927023476 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 749927023477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927023478 dimer interface [polypeptide binding]; other site 749927023479 conserved gate region; other site 749927023480 putative PBP binding loops; other site 749927023481 ABC-ATPase subunit interface; other site 749927023482 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 749927023483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927023484 dimer interface [polypeptide binding]; other site 749927023485 conserved gate region; other site 749927023486 putative PBP binding loops; other site 749927023487 ABC-ATPase subunit interface; other site 749927023488 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 749927023489 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927023490 Walker A/P-loop; other site 749927023491 ATP binding site [chemical binding]; other site 749927023492 Q-loop/lid; other site 749927023493 ABC transporter signature motif; other site 749927023494 Walker B; other site 749927023495 D-loop; other site 749927023496 H-loop/switch region; other site 749927023497 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927023498 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 749927023499 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 749927023500 substrate binding site [chemical binding]; other site 749927023501 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 749927023502 putative switch regulator; other site 749927023503 non-specific DNA interactions [nucleotide binding]; other site 749927023504 DNA binding site [nucleotide binding] 749927023505 sequence specific DNA binding site [nucleotide binding]; other site 749927023506 putative cAMP binding site [chemical binding]; other site 749927023507 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927023508 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927023509 nucleotide binding site [chemical binding]; other site 749927023510 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927023511 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 749927023512 putative switch regulator; other site 749927023513 non-specific DNA interactions [nucleotide binding]; other site 749927023514 DNA binding site [nucleotide binding] 749927023515 sequence specific DNA binding site [nucleotide binding]; other site 749927023516 putative cAMP binding site [chemical binding]; other site 749927023517 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927023518 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927023519 nucleotide binding site [chemical binding]; other site 749927023520 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 749927023521 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 749927023522 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 749927023523 active site 749927023524 catalytic residues [active] 749927023525 Ricin-type beta-trefoil; Region: RICIN; smart00458 749927023526 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927023527 putative sugar binding sites [chemical binding]; other site 749927023528 Q-X-W motif; other site 749927023529 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 749927023530 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927023531 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927023532 putative sugar binding sites [chemical binding]; other site 749927023533 Q-X-W motif; other site 749927023534 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 749927023535 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927023536 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927023537 putative sugar binding sites [chemical binding]; other site 749927023538 Q-X-W motif; other site 749927023539 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927023540 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927023541 putative sugar binding sites [chemical binding]; other site 749927023542 Q-X-W motif; other site 749927023543 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 749927023544 active site 749927023545 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 749927023546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927023547 DNA-binding site [nucleotide binding]; DNA binding site 749927023548 FCD domain; Region: FCD; pfam07729 749927023549 putative sialic acid transporter; Region: 2A0112; TIGR00891 749927023550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927023551 putative substrate translocation pore; other site 749927023552 hypothetical protein; Provisional; Region: PRK05463 749927023553 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 749927023554 putative active site [active] 749927023555 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 749927023556 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 749927023557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927023558 putative DNA binding site [nucleotide binding]; other site 749927023559 dimerization interface [polypeptide binding]; other site 749927023560 putative Zn2+ binding site [ion binding]; other site 749927023561 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 749927023562 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927023563 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 749927023564 NAD(P) binding site [chemical binding]; other site 749927023565 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927023566 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 749927023567 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 749927023568 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 749927023569 FeoA domain; Region: FeoA; pfam04023 749927023570 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 749927023571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927023572 Coenzyme A binding pocket [chemical binding]; other site 749927023573 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 749927023574 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 749927023575 active site 749927023576 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 749927023577 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927023578 substrate binding site [chemical binding]; other site 749927023579 oxyanion hole (OAH) forming residues; other site 749927023580 trimer interface [polypeptide binding]; other site 749927023581 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 749927023582 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927023583 acyl-activating enzyme (AAE) consensus motif; other site 749927023584 AMP binding site [chemical binding]; other site 749927023585 active site 749927023586 CoA binding site [chemical binding]; other site 749927023587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927023588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927023589 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 749927023590 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927023591 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927023592 active site 749927023593 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 749927023594 isochorismate synthase DhbC; Validated; Region: PRK06923 749927023595 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 749927023596 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 749927023597 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 749927023598 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 749927023599 dimer interface [polypeptide binding]; other site 749927023600 acyl-activating enzyme (AAE) consensus motif; other site 749927023601 putative active site [active] 749927023602 AMP binding site [chemical binding]; other site 749927023603 putative CoA binding site [chemical binding]; other site 749927023604 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 749927023605 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 749927023606 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927023607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927023608 dimer interface [polypeptide binding]; other site 749927023609 conserved gate region; other site 749927023610 putative PBP binding loops; other site 749927023611 ABC-ATPase subunit interface; other site 749927023612 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 749927023613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927023614 dimer interface [polypeptide binding]; other site 749927023615 conserved gate region; other site 749927023616 putative PBP binding loops; other site 749927023617 ABC-ATPase subunit interface; other site 749927023618 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 749927023619 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 749927023620 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 749927023621 CoenzymeA binding site [chemical binding]; other site 749927023622 subunit interaction site [polypeptide binding]; other site 749927023623 PHB binding site; other site 749927023624 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 749927023625 putative active site [active] 749927023626 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 749927023627 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927023628 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 749927023629 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927023630 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927023631 DNA binding residues [nucleotide binding] 749927023632 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927023633 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 749927023634 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 749927023635 NAD binding site [chemical binding]; other site 749927023636 catalytic Zn binding site [ion binding]; other site 749927023637 substrate binding site [chemical binding]; other site 749927023638 structural Zn binding site [ion binding]; other site 749927023639 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 749927023640 putative active site pocket [active] 749927023641 dimerization interface [polypeptide binding]; other site 749927023642 putative catalytic residue [active] 749927023643 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 749927023644 FAD binding domain; Region: FAD_binding_4; pfam01565 749927023645 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 749927023646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927023647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927023648 FAD dependent oxidoreductase; Region: DAO; pfam01266 749927023649 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927023650 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927023651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927023652 salt bridge; other site 749927023653 non-specific DNA binding site [nucleotide binding]; other site 749927023654 sequence-specific DNA binding site [nucleotide binding]; other site 749927023655 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 749927023656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927023657 Walker A/P-loop; other site 749927023658 ATP binding site [chemical binding]; other site 749927023659 Q-loop/lid; other site 749927023660 ABC transporter signature motif; other site 749927023661 Walker B; other site 749927023662 D-loop; other site 749927023663 H-loop/switch region; other site 749927023664 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 749927023665 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 749927023666 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927023667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927023668 Coenzyme A binding pocket [chemical binding]; other site 749927023669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 749927023670 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 749927023671 DNA photolyase; Region: DNA_photolyase; pfam00875 749927023672 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 749927023673 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 749927023674 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 749927023675 dimer interface [polypeptide binding]; other site 749927023676 active site 749927023677 citrylCoA binding site [chemical binding]; other site 749927023678 NADH binding [chemical binding]; other site 749927023679 cationic pore residues; other site 749927023680 oxalacetate/citrate binding site [chemical binding]; other site 749927023681 coenzyme A binding site [chemical binding]; other site 749927023682 catalytic triad [active] 749927023683 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 749927023684 putative substrate binding site [chemical binding]; other site 749927023685 putative ATP binding site [chemical binding]; other site 749927023686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927023687 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 749927023688 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 749927023689 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927023690 active site 749927023691 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 749927023692 putative active site [active] 749927023693 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 749927023694 putative active site [active] 749927023695 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 749927023696 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 749927023697 active site 749927023698 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 749927023699 active site 749927023700 catalytic residues [active] 749927023701 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 749927023702 peptidase domain interface [polypeptide binding]; other site 749927023703 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 749927023704 active site 749927023705 catalytic triad [active] 749927023706 calcium binding site [ion binding]; other site 749927023707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927023708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927023709 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927023710 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 749927023711 envelope glycoprotein C; Provisional; Region: PHA03269 749927023712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927023713 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927023714 putative substrate translocation pore; other site 749927023715 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 749927023716 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 749927023717 Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590 749927023718 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 749927023719 Na binding site [ion binding]; other site 749927023720 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927023721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927023722 Secretory lipase; Region: LIP; pfam03583 749927023723 UreD urease accessory protein; Region: UreD; cl00530 749927023724 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927023725 UreF; Region: UreF; cl19817 749927023726 urease subunit alpha; Reviewed; Region: ureC; PRK13206 749927023727 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 749927023728 subunit interactions [polypeptide binding]; other site 749927023729 active site 749927023730 flap region; other site 749927023731 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 749927023732 gamma-beta subunit interface [polypeptide binding]; other site 749927023733 alpha-beta subunit interface [polypeptide binding]; other site 749927023734 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 749927023735 alpha-gamma subunit interface [polypeptide binding]; other site 749927023736 beta-gamma subunit interface [polypeptide binding]; other site 749927023737 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 749927023738 citrate synthase 2; Provisional; Region: PRK12350 749927023739 oxalacetate binding site [chemical binding]; other site 749927023740 citrylCoA binding site [chemical binding]; other site 749927023741 coenzyme A binding site [chemical binding]; other site 749927023742 catalytic triad [active] 749927023743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927023744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927023745 short chain dehydrogenase; Validated; Region: PRK05855 749927023746 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927023747 classical (c) SDRs; Region: SDR_c; cd05233 749927023748 NAD(P) binding site [chemical binding]; other site 749927023749 active site 749927023750 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927023751 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 749927023752 Walker A/P-loop; other site 749927023753 ATP binding site [chemical binding]; other site 749927023754 Q-loop/lid; other site 749927023755 ABC transporter signature motif; other site 749927023756 Walker B; other site 749927023757 D-loop; other site 749927023758 H-loop/switch region; other site 749927023759 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 749927023760 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 749927023761 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927023762 Histidine kinase; Region: HisKA_3; pfam07730 749927023763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927023764 ATP binding site [chemical binding]; other site 749927023765 Mg2+ binding site [ion binding]; other site 749927023766 G-X-G motif; other site 749927023767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927023768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927023769 active site 749927023770 phosphorylation site [posttranslational modification] 749927023771 intermolecular recognition site; other site 749927023772 dimerization interface [polypeptide binding]; other site 749927023773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927023774 DNA binding residues [nucleotide binding] 749927023775 dimerization interface [polypeptide binding]; other site 749927023776 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927023777 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927023778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927023779 catalytic residue [active] 749927023780 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 749927023781 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 749927023782 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927023783 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 749927023784 active site 749927023785 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 749927023786 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 749927023787 FtsX-like permease family; Region: FtsX; pfam02687 749927023788 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 749927023789 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 749927023790 Walker A/P-loop; other site 749927023791 ATP binding site [chemical binding]; other site 749927023792 Q-loop/lid; other site 749927023793 ABC transporter signature motif; other site 749927023794 Walker B; other site 749927023795 D-loop; other site 749927023796 H-loop/switch region; other site 749927023797 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927023798 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927023799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927023800 active site 749927023801 phosphorylation site [posttranslational modification] 749927023802 intermolecular recognition site; other site 749927023803 dimerization interface [polypeptide binding]; other site 749927023804 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927023805 DNA binding site [nucleotide binding] 749927023806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927023807 dimerization interface [polypeptide binding]; other site 749927023808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927023809 dimer interface [polypeptide binding]; other site 749927023810 phosphorylation site [posttranslational modification] 749927023811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927023812 ATP binding site [chemical binding]; other site 749927023813 Mg2+ binding site [ion binding]; other site 749927023814 G-X-G motif; other site 749927023815 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 749927023816 YjbR; Region: YjbR; pfam04237 749927023817 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 749927023818 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 749927023819 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 749927023820 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 749927023821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927023822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927023823 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 749927023824 heme binding pocket [chemical binding]; other site 749927023825 heme ligand [chemical binding]; other site 749927023826 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 749927023827 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 749927023828 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 749927023829 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 749927023830 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927023831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927023832 putative substrate translocation pore; other site 749927023833 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927023834 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927023835 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 749927023836 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 749927023837 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 749927023838 Glutamine cyclotransferase; Region: Glu_cyclase_2; cl19848 749927023839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927023840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927023841 putative substrate translocation pore; other site 749927023842 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 749927023843 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 749927023844 DNA-binding site [nucleotide binding]; DNA binding site 749927023845 RNA-binding motif; other site 749927023846 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 749927023847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927023848 motif II; other site 749927023849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927023850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927023851 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 749927023852 active site 749927023853 diiron metal binding site [ion binding]; other site 749927023854 AMP-binding domain protein; Validated; Region: PRK08315 749927023855 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 749927023856 acyl-activating enzyme (AAE) consensus motif; other site 749927023857 putative AMP binding site [chemical binding]; other site 749927023858 putative active site [active] 749927023859 putative CoA binding site [chemical binding]; other site 749927023860 Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908 749927023861 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927023862 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927023863 DNA binding residues [nucleotide binding] 749927023864 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927023865 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927023866 putative sugar binding sites [chemical binding]; other site 749927023867 Q-X-W motif; other site 749927023868 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 749927023869 Asp-box motif; other site 749927023870 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 749927023871 Ycf46; Provisional; Region: ycf46; CHL00195 749927023872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927023873 Walker A motif; other site 749927023874 ATP binding site [chemical binding]; other site 749927023875 Walker B motif; other site 749927023876 arginine finger; other site 749927023877 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 749927023878 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 749927023879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927023880 FeS/SAM binding site; other site 749927023881 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 749927023882 EspG family; Region: ESX-1_EspG; pfam14011 749927023883 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 749927023884 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 749927023885 hypothetical protein; Provisional; Region: PRK11770 749927023886 Domain of unknown function (DUF307); Region: DUF307; pfam03733 749927023887 Domain of unknown function (DUF307); Region: DUF307; pfam03733 749927023888 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927023889 active site 749927023890 metal binding site [ion binding]; metal-binding site 749927023891 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 749927023892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927023893 active site 749927023894 motif I; other site 749927023895 motif II; other site 749927023896 Cupredoxin superfamily; Region: Cupredoxin; cl19115 749927023897 Cupredoxin superfamily; Region: Cupredoxin; cl19115 749927023898 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 749927023899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927023900 Walker A/P-loop; other site 749927023901 ATP binding site [chemical binding]; other site 749927023902 Q-loop/lid; other site 749927023903 ABC transporter signature motif; other site 749927023904 Walker B; other site 749927023905 D-loop; other site 749927023906 H-loop/switch region; other site 749927023907 TOBE domain; Region: TOBE; pfam03459 749927023908 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 749927023909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927023910 dimer interface [polypeptide binding]; other site 749927023911 conserved gate region; other site 749927023912 putative PBP binding loops; other site 749927023913 ABC-ATPase subunit interface; other site 749927023914 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 749927023915 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927023916 DNA binding residues [nucleotide binding] 749927023917 TOBE domain; Region: TOBE; cl01440 749927023918 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927023919 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927023920 putative Zn2+ binding site [ion binding]; other site 749927023921 putative DNA binding site [nucleotide binding]; other site 749927023922 dimerization interface [polypeptide binding]; other site 749927023923 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 749927023924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 749927023925 FeS/SAM binding site; other site 749927023926 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 749927023927 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 749927023928 MoaE interaction surface [polypeptide binding]; other site 749927023929 MoeB interaction surface [polypeptide binding]; other site 749927023930 thiocarboxylated glycine; other site 749927023931 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 749927023932 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 749927023933 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 749927023934 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 749927023935 MPT binding site; other site 749927023936 trimer interface [polypeptide binding]; other site 749927023937 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 749927023938 MoaE homodimer interface [polypeptide binding]; other site 749927023939 MoaD interaction [polypeptide binding]; other site 749927023940 active site residues [active] 749927023941 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 749927023942 trimer interface [polypeptide binding]; other site 749927023943 dimer interface [polypeptide binding]; other site 749927023944 putative active site [active] 749927023945 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 749927023946 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 749927023947 Malic enzyme, N-terminal domain; Region: malic; pfam00390 749927023948 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 749927023949 putative NAD(P) binding site [chemical binding]; other site 749927023950 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 749927023951 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927023952 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 749927023953 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 749927023954 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 749927023955 G1 box; other site 749927023956 GTP/Mg2+ binding site [chemical binding]; other site 749927023957 G2 box; other site 749927023958 Switch I region; other site 749927023959 G3 box; other site 749927023960 Switch II region; other site 749927023961 G4 box; other site 749927023962 G5 box; other site 749927023963 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927023964 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 749927023965 Nitrate and nitrite sensing; Region: NIT; pfam08376 749927023966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927023967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927023968 ATP binding site [chemical binding]; other site 749927023969 Mg2+ binding site [ion binding]; other site 749927023970 G-X-G motif; other site 749927023971 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749927023972 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749927023973 substrate binding pocket [chemical binding]; other site 749927023974 membrane-bound complex binding site; other site 749927023975 hinge residues; other site 749927023976 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749927023977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927023978 dimer interface [polypeptide binding]; other site 749927023979 conserved gate region; other site 749927023980 putative PBP binding loops; other site 749927023981 ABC-ATPase subunit interface; other site 749927023982 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749927023983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927023984 dimer interface [polypeptide binding]; other site 749927023985 conserved gate region; other site 749927023986 putative PBP binding loops; other site 749927023987 ABC-ATPase subunit interface; other site 749927023988 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 749927023989 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 749927023990 Walker A/P-loop; other site 749927023991 ATP binding site [chemical binding]; other site 749927023992 Q-loop/lid; other site 749927023993 ABC transporter signature motif; other site 749927023994 Walker B; other site 749927023995 D-loop; other site 749927023996 H-loop/switch region; other site 749927023997 benzoylformate decarboxylase; Reviewed; Region: PRK07092 749927023998 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 749927023999 PYR/PP interface [polypeptide binding]; other site 749927024000 dimer interface [polypeptide binding]; other site 749927024001 TPP binding site [chemical binding]; other site 749927024002 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 749927024003 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 749927024004 TPP-binding site [chemical binding]; other site 749927024005 dimer interface [polypeptide binding]; other site 749927024006 Helix-turn-helix; Region: HTH_3; pfam01381 749927024007 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 749927024008 peptidase domain interface [polypeptide binding]; other site 749927024009 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 749927024010 active site 749927024011 catalytic triad [active] 749927024012 calcium binding site [ion binding]; other site 749927024013 CutC family; Region: CutC; cl01218 749927024014 Nitrate and nitrite sensing; Region: NIT; pfam08376 749927024015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927024016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927024017 ATP binding site [chemical binding]; other site 749927024018 Mg2+ binding site [ion binding]; other site 749927024019 G-X-G motif; other site 749927024020 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 749927024021 NMT1-like family; Region: NMT1_2; cl17432 749927024022 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 749927024023 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 749927024024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927024025 ATP binding site [chemical binding]; other site 749927024026 putative Mg++ binding site [ion binding]; other site 749927024027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927024028 nucleotide binding region [chemical binding]; other site 749927024029 ATP-binding site [chemical binding]; other site 749927024030 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 749927024031 Protein of unknown function DUF72; Region: DUF72; pfam01904 749927024032 O-succinylbenzoate synthase; Provisional; Region: PRK02901 749927024033 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 749927024034 active site 749927024035 PspC domain; Region: PspC; pfam04024 749927024036 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 749927024037 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 749927024038 ring oligomerisation interface [polypeptide binding]; other site 749927024039 ATP/Mg binding site [chemical binding]; other site 749927024040 stacking interactions; other site 749927024041 hinge regions; other site 749927024042 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927024043 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927024044 active site 749927024045 ATP binding site [chemical binding]; other site 749927024046 substrate binding site [chemical binding]; other site 749927024047 activation loop (A-loop); other site 749927024048 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 749927024049 DNA-binding site [nucleotide binding]; DNA binding site 749927024050 RNA-binding motif; other site 749927024051 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 749927024052 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 749927024053 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 749927024054 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 749927024055 dimer interface [polypeptide binding]; other site 749927024056 putative functional site; other site 749927024057 putative MPT binding site; other site 749927024058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927024059 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927024060 putative substrate translocation pore; other site 749927024061 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927024062 putative DNA binding site [nucleotide binding]; other site 749927024063 putative Zn2+ binding site [ion binding]; other site 749927024064 Predicted membrane protein [Function unknown]; Region: COG2261 749927024065 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 749927024066 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 749927024067 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 749927024068 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 749927024069 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 749927024070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927024071 Walker A motif; other site 749927024072 ATP binding site [chemical binding]; other site 749927024073 Walker B motif; other site 749927024074 arginine finger; other site 749927024075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927024076 Walker A motif; other site 749927024077 ATP binding site [chemical binding]; other site 749927024078 Walker B motif; other site 749927024079 arginine finger; other site 749927024080 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 749927024081 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 749927024082 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 749927024083 active site 749927024084 catalytic residues [active] 749927024085 metal binding site [ion binding]; metal-binding site 749927024086 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 749927024087 Domain interface; other site 749927024088 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 749927024089 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 749927024090 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927024091 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 749927024092 protein binding site [polypeptide binding]; other site 749927024093 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 749927024094 ThiC-associated domain; Region: ThiC-associated; pfam13667 749927024095 ThiC family; Region: ThiC; pfam01964 749927024096 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 749927024097 dimer interface [polypeptide binding]; other site 749927024098 substrate binding site [chemical binding]; other site 749927024099 ATP binding site [chemical binding]; other site 749927024100 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 749927024101 putative active site [active] 749927024102 catalytic site [active] 749927024103 putative metal binding site [ion binding]; other site 749927024104 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 749927024105 substrate binding site [chemical binding]; other site 749927024106 dimer interface [polypeptide binding]; other site 749927024107 ATP binding site [chemical binding]; other site 749927024108 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927024109 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927024110 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 749927024111 ThiS interaction site; other site 749927024112 putative active site [active] 749927024113 tetramer interface [polypeptide binding]; other site 749927024114 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 749927024115 thiS-thiF/thiG interaction site; other site 749927024116 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 749927024117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927024118 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 749927024119 thiamine phosphate binding site [chemical binding]; other site 749927024120 active site 749927024121 pyrophosphate binding site [ion binding]; other site 749927024122 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 749927024123 tetramer interface [polypeptide binding]; other site 749927024124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927024125 catalytic residue [active] 749927024126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927024127 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927024128 putative substrate translocation pore; other site 749927024129 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 749927024130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927024131 DNA-binding site [nucleotide binding]; DNA binding site 749927024132 UTRA domain; Region: UTRA; pfam07702 749927024133 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 749927024134 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 749927024135 dimer interface [polypeptide binding]; other site 749927024136 active site 749927024137 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 749927024138 dimer interface [polypeptide binding]; other site 749927024139 active site 749927024140 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 749927024141 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 749927024142 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 749927024143 active site 749927024144 catalytic triad [active] 749927024145 oxyanion hole [active] 749927024146 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 749927024147 ligand binding site [chemical binding]; other site 749927024148 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 749927024149 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927024150 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 749927024151 DNA binding site [nucleotide binding] 749927024152 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927024153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927024154 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 749927024155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927024156 binding surface 749927024157 TPR motif; other site 749927024158 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 749927024159 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 749927024160 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 749927024161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 749927024162 inhibitor-cofactor binding pocket; inhibition site 749927024163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927024164 catalytic residue [active] 749927024165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927024166 Coenzyme A binding pocket [chemical binding]; other site 749927024167 patatin-related protein; Region: TIGR03607 749927024168 Patatin-like phospholipase; Region: Patatin; pfam01734 749927024169 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 749927024170 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 749927024171 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927024172 putative NAD(P) binding site [chemical binding]; other site 749927024173 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927024174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 749927024175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 749927024176 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 749927024177 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 749927024178 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927024179 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 749927024180 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 749927024181 active site 749927024182 dimer interface [polypeptide binding]; other site 749927024183 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927024184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927024185 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927024186 active site 749927024187 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 749927024188 active site 749927024189 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 749927024190 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 749927024191 acyl-activating enzyme (AAE) consensus motif; other site 749927024192 AMP binding site [chemical binding]; other site 749927024193 active site 749927024194 CoA binding site [chemical binding]; other site 749927024195 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 749927024196 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 749927024197 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 749927024198 substrate binding site [chemical binding]; other site 749927024199 oxyanion hole (OAH) forming residues; other site 749927024200 trimer interface [polypeptide binding]; other site 749927024201 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl18948 749927024202 substrate binding site [chemical binding]; other site 749927024203 trimer interface [polypeptide binding]; other site 749927024204 oxyanion hole (OAH) forming residues; other site 749927024205 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927024206 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927024207 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 749927024208 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 749927024209 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 749927024210 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 749927024211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927024212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927024213 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927024214 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927024215 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 749927024216 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927024217 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927024218 MarR family; Region: MarR_2; pfam12802 749927024219 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 749927024220 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 749927024221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927024222 Walker A/P-loop; other site 749927024223 ATP binding site [chemical binding]; other site 749927024224 Q-loop/lid; other site 749927024225 ABC transporter signature motif; other site 749927024226 Walker B; other site 749927024227 D-loop; other site 749927024228 H-loop/switch region; other site 749927024229 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 749927024230 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 749927024231 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 749927024232 Zn binding site [ion binding]; other site 749927024233 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 749927024234 NHL repeat; Region: NHL; pfam01436 749927024235 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 749927024236 NHL repeat; Region: NHL; pfam01436 749927024237 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 749927024238 Gas vesicle protein; Region: Gas_vesicle; cl02954 749927024239 Gas vesicle protein K; Region: GvpK; pfam05121 749927024240 Gas vesicle protein; Region: Gas_vesicle; pfam00741 749927024241 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 749927024242 Gas vesicle protein; Region: Gas_vesicle; pfam00741 749927024243 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 749927024244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927024245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927024246 active site 749927024247 phosphorylation site [posttranslational modification] 749927024248 intermolecular recognition site; other site 749927024249 dimerization interface [polypeptide binding]; other site 749927024250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927024251 DNA binding site [nucleotide binding] 749927024252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927024253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927024254 dimerization interface [polypeptide binding]; other site 749927024255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927024256 dimer interface [polypeptide binding]; other site 749927024257 phosphorylation site [posttranslational modification] 749927024258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927024259 ATP binding site [chemical binding]; other site 749927024260 Mg2+ binding site [ion binding]; other site 749927024261 G-X-G motif; other site 749927024262 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 749927024263 catalytic triad [active] 749927024264 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 749927024265 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 749927024266 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927024267 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 749927024268 putative NAD(P) binding site [chemical binding]; other site 749927024269 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927024270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927024271 Class I aldolases; Region: Aldolase_Class_I; cl17187 749927024272 catalytic residue [active] 749927024273 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 749927024274 Transcriptional regulator [Transcription]; Region: IclR; COG1414 749927024275 Bacterial transcriptional regulator; Region: IclR; pfam01614 749927024276 L-lactate permease; Region: Lactate_perm; cl00701 749927024277 HD domain; Region: HD_3; pfam13023 749927024278 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927024279 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927024280 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927024281 YCII-related domain; Region: YCII; cl00999 749927024282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 749927024283 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 749927024284 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 749927024285 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 749927024286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 749927024287 dimerization interface [polypeptide binding]; other site 749927024288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927024289 dimer interface [polypeptide binding]; other site 749927024290 phosphorylation site [posttranslational modification] 749927024291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927024292 ATP binding site [chemical binding]; other site 749927024293 Mg2+ binding site [ion binding]; other site 749927024294 G-X-G motif; other site 749927024295 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 749927024296 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 749927024297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 749927024298 binding surface 749927024299 TPR motif; other site 749927024300 Tetratricopeptide repeat; Region: TPR_12; pfam13424 749927024301 CHAT domain; Region: CHAT; pfam12770 749927024302 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927024303 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927024304 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927024305 active site 749927024306 catalytic residues [active] 749927024307 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 749927024308 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 749927024309 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 749927024310 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 749927024311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927024312 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927024313 DNA binding residues [nucleotide binding] 749927024314 SnoaL-like domain; Region: SnoaL_2; pfam12680 749927024315 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927024316 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 749927024317 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 749927024318 sugar binding site [chemical binding]; other site 749927024319 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 749927024320 metal binding site [ion binding]; metal-binding site 749927024321 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 749927024322 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 749927024323 Ca binding site [ion binding]; other site 749927024324 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 749927024325 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 749927024326 active site 749927024327 catalytic residues [active] 749927024328 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 749927024329 Erythromycin esterase; Region: Erythro_esteras; cl17110 749927024330 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927024331 DNA binding residues [nucleotide binding] 749927024332 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927024333 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 749927024334 DNA binding residues [nucleotide binding] 749927024335 putative dimer interface [polypeptide binding]; other site 749927024336 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927024337 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927024338 Uncharacterized conserved protein [Function unknown]; Region: COG2966 749927024339 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 749927024340 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 749927024341 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 749927024342 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 749927024343 active site 749927024344 homotetramer interface [polypeptide binding]; other site 749927024345 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 749927024346 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 749927024347 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 749927024348 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 749927024349 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927024350 dimerization interface [polypeptide binding]; other site 749927024351 putative DNA binding site [nucleotide binding]; other site 749927024352 putative Zn2+ binding site [ion binding]; other site 749927024353 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927024354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927024355 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927024356 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927024357 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927024358 DNA binding residues [nucleotide binding] 749927024359 DNA repair protein RadA; Provisional; Region: PRK11823 749927024360 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 749927024361 Walker A motif; other site 749927024362 ATP binding site [chemical binding]; other site 749927024363 Walker B motif; other site 749927024364 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 749927024365 Calx-beta domain; Region: Calx-beta; cl02522 749927024366 Protein of unknown function (DUF461); Region: DUF461; cl01071 749927024367 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 749927024368 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927024369 active site 749927024370 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 749927024371 homotrimer interaction site [polypeptide binding]; other site 749927024372 zinc binding site [ion binding]; other site 749927024373 CDP-binding sites; other site 749927024374 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 749927024375 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 749927024376 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 749927024377 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927024378 motif II; other site 749927024379 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 749927024380 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 749927024381 active site 749927024382 HIGH motif; other site 749927024383 KMSKS motif; other site 749927024384 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 749927024385 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 749927024386 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 749927024387 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 749927024388 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 749927024389 phosphoglycerate mutase; Provisional; Region: PTZ00122 749927024390 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 749927024391 catalytic core [active] 749927024392 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 749927024393 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 749927024394 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 749927024395 intersubunit interface [polypeptide binding]; other site 749927024396 active site 749927024397 Zn2+ binding site [ion binding]; other site 749927024398 MAEBL; Provisional; Region: PTZ00121 749927024399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 749927024400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 749927024401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 749927024402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 749927024403 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 749927024404 ABC-ATPase subunit interface; other site 749927024405 dimer interface [polypeptide binding]; other site 749927024406 putative PBP binding regions; other site 749927024407 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 749927024408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927024409 Walker A/P-loop; other site 749927024410 ATP binding site [chemical binding]; other site 749927024411 Q-loop/lid; other site 749927024412 ABC transporter signature motif; other site 749927024413 Walker B; other site 749927024414 D-loop; other site 749927024415 H-loop/switch region; other site 749927024416 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 749927024417 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 749927024418 intersubunit interface [polypeptide binding]; other site 749927024419 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927024420 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927024421 DNA binding site [nucleotide binding] 749927024422 domain linker motif; other site 749927024423 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 749927024424 putative dimerization interface [polypeptide binding]; other site 749927024425 putative ligand binding site [chemical binding]; other site 749927024426 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 749927024427 active site clefts [active] 749927024428 zinc binding site [ion binding]; other site 749927024429 dimer interface [polypeptide binding]; other site 749927024430 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 749927024431 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927024432 homodimer interface [polypeptide binding]; other site 749927024433 active site 749927024434 TDP-binding site; other site 749927024435 acceptor substrate-binding pocket; other site 749927024436 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 749927024437 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 749927024438 minor groove reading motif; other site 749927024439 helix-hairpin-helix signature motif; other site 749927024440 substrate binding pocket [chemical binding]; other site 749927024441 active site 749927024442 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 749927024443 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 749927024444 amidase catalytic site [active] 749927024445 Zn binding residues [ion binding]; other site 749927024446 substrate binding site [chemical binding]; other site 749927024447 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927024448 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927024449 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927024450 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 749927024451 Zn binding site [ion binding]; other site 749927024452 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 749927024453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927024454 Walker A motif; other site 749927024455 ATP binding site [chemical binding]; other site 749927024456 Walker B motif; other site 749927024457 arginine finger; other site 749927024458 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 749927024459 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 749927024460 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 749927024461 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 749927024462 Walker A motif; other site 749927024463 ATP binding site [chemical binding]; other site 749927024464 Walker B motif; other site 749927024465 hypothetical protein; Validated; Region: PRK09169 749927024466 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 749927024467 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 749927024468 putative catalytic site [active] 749927024469 putative metal binding site [ion binding]; other site 749927024470 putative phosphate binding site [ion binding]; other site 749927024471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927024472 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 749927024473 Walker A/P-loop; other site 749927024474 ATP binding site [chemical binding]; other site 749927024475 Q-loop/lid; other site 749927024476 ABC transporter signature motif; other site 749927024477 Walker B; other site 749927024478 D-loop; other site 749927024479 H-loop/switch region; other site 749927024480 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 749927024481 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 749927024482 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 749927024483 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 749927024484 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 749927024485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 749927024486 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 749927024487 Zn binding site [ion binding]; other site 749927024488 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 749927024489 putative substrate binding pocket [chemical binding]; other site 749927024490 AC domain interface; other site 749927024491 catalytic triad [active] 749927024492 AB domain interface; other site 749927024493 interchain disulfide; other site 749927024494 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 749927024495 nucleotide binding site [chemical binding]; other site 749927024496 putative NEF/HSP70 interaction site [polypeptide binding]; other site 749927024497 SBD interface [polypeptide binding]; other site 749927024498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927024499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927024500 non-specific DNA binding site [nucleotide binding]; other site 749927024501 salt bridge; other site 749927024502 sequence-specific DNA binding site [nucleotide binding]; other site 749927024503 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 749927024504 Clp amino terminal domain; Region: Clp_N; pfam02861 749927024505 Clp amino terminal domain; Region: Clp_N; pfam02861 749927024506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927024507 Walker A motif; other site 749927024508 ATP binding site [chemical binding]; other site 749927024509 Walker B motif; other site 749927024510 arginine finger; other site 749927024511 UvrB/uvrC motif; Region: UVR; pfam02151 749927024512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927024513 Walker A motif; other site 749927024514 ATP binding site [chemical binding]; other site 749927024515 Walker B motif; other site 749927024516 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 749927024517 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 749927024518 TIGR03086 family protein; Region: TIGR03086 749927024519 Helix-turn-helix domain; Region: HTH_18; pfam12833 749927024520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 749927024521 Lsr2; Region: Lsr2; pfam11774 749927024522 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 749927024523 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 749927024524 dimer interface [polypeptide binding]; other site 749927024525 putative anticodon binding site; other site 749927024526 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 749927024527 motif 1; other site 749927024528 dimer interface [polypeptide binding]; other site 749927024529 active site 749927024530 motif 2; other site 749927024531 motif 3; other site 749927024532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927024533 S-adenosylmethionine binding site [chemical binding]; other site 749927024534 pantothenate kinase; Reviewed; Region: PRK13318 749927024535 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 749927024536 tetramerization interface [polypeptide binding]; other site 749927024537 active site 749927024538 Pantoate-beta-alanine ligase; Region: PanC; cd00560 749927024539 active site 749927024540 ATP-binding site [chemical binding]; other site 749927024541 pantoate-binding site; other site 749927024542 HXXH motif; other site 749927024543 Uncharacterized conserved protein [Function unknown]; Region: COG5495 749927024544 Rossmann-like domain; Region: Rossmann-like; pfam10727 749927024545 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 749927024546 Protease prsW family; Region: PrsW-protease; pfam13367 749927024547 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 749927024548 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 749927024549 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 749927024550 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927024551 DNA binding residues [nucleotide binding] 749927024552 dimer interface [polypeptide binding]; other site 749927024553 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 749927024554 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 749927024555 catalytic center binding site [active] 749927024556 ATP binding site [chemical binding]; other site 749927024557 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 749927024558 homooctamer interface [polypeptide binding]; other site 749927024559 active site 749927024560 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 749927024561 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 749927024562 substrate binding pocket [chemical binding]; other site 749927024563 dimer interface [polypeptide binding]; other site 749927024564 inhibitor binding site; inhibition site 749927024565 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 749927024566 active site 749927024567 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 749927024568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927024569 Walker A motif; other site 749927024570 ATP binding site [chemical binding]; other site 749927024571 Walker B motif; other site 749927024572 arginine finger; other site 749927024573 Peptidase family M41; Region: Peptidase_M41; pfam01434 749927024574 EspG family; Region: ESX-1_EspG; pfam14011 749927024575 EspG family; Region: ESX-1_EspG; pfam14011 749927024576 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927024577 active site 749927024578 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 749927024579 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 749927024580 Ligand Binding Site [chemical binding]; other site 749927024581 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 749927024582 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 749927024583 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 749927024584 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 749927024585 dimer interface [polypeptide binding]; other site 749927024586 substrate binding site [chemical binding]; other site 749927024587 metal binding sites [ion binding]; metal-binding site 749927024588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927024589 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 749927024590 putative substrate translocation pore; other site 749927024591 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 749927024592 dimer interface [polypeptide binding]; other site 749927024593 active site 749927024594 glycine-pyridoxal phosphate binding site [chemical binding]; other site 749927024595 folate binding site [chemical binding]; other site 749927024596 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 749927024597 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 749927024598 23S rRNA interface [nucleotide binding]; other site 749927024599 L7/L12 interface [polypeptide binding]; other site 749927024600 putative thiostrepton binding site; other site 749927024601 L25 interface [polypeptide binding]; other site 749927024602 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 749927024603 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 749927024604 trimer interface [polypeptide binding]; other site 749927024605 putative metal binding site [ion binding]; other site 749927024606 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 749927024607 putative active site [active] 749927024608 Zn binding site [ion binding]; other site 749927024609 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 749927024610 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927024611 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 749927024612 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 749927024613 EthD domain; Region: EthD; cl17553 749927024614 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927024615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927024616 non-specific DNA binding site [nucleotide binding]; other site 749927024617 salt bridge; other site 749927024618 sequence-specific DNA binding site [nucleotide binding]; other site 749927024619 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 749927024620 nudix motif; other site 749927024621 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927024622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927024623 non-specific DNA binding site [nucleotide binding]; other site 749927024624 salt bridge; other site 749927024625 sequence-specific DNA binding site [nucleotide binding]; other site 749927024626 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 749927024627 Phosphotransferase enzyme family; Region: APH; pfam01636 749927024628 substrate binding site [chemical binding]; other site 749927024629 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 749927024630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927024631 DNA-binding site [nucleotide binding]; DNA binding site 749927024632 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927024633 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927024634 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 749927024635 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 749927024636 Helix-turn-helix domain; Region: HTH_17; cl17695 749927024637 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 749927024638 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 749927024639 Phage integrase family; Region: Phage_integrase; pfam00589 749927024640 active site 749927024641 DNA binding site [nucleotide binding] 749927024642 Int/Topo IB signature motif; other site 749927024643 DNA polymerase III subunit delta'; Validated; Region: PRK07940 749927024644 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927024645 Walker A motif; other site 749927024646 ATP binding site [chemical binding]; other site 749927024647 Walker B motif; other site 749927024648 arginine finger; other site 749927024649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927024650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927024651 putative substrate translocation pore; other site 749927024652 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 749927024653 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 749927024654 TMP-binding site; other site 749927024655 ATP-binding site [chemical binding]; other site 749927024656 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 749927024657 EspG family; Region: ESX-1_EspG; pfam14011 749927024658 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 749927024659 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 749927024660 active site 749927024661 interdomain interaction site; other site 749927024662 putative metal-binding site [ion binding]; other site 749927024663 nucleotide binding site [chemical binding]; other site 749927024664 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 749927024665 domain I; other site 749927024666 DNA binding groove [nucleotide binding] 749927024667 phosphate binding site [ion binding]; other site 749927024668 domain II; other site 749927024669 domain III; other site 749927024670 nucleotide binding site [chemical binding]; other site 749927024671 catalytic site [active] 749927024672 domain IV; other site 749927024673 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 749927024674 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 749927024675 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927024676 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 749927024677 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 749927024678 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 749927024679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927024680 ATP binding site [chemical binding]; other site 749927024681 putative Mg++ binding site [ion binding]; other site 749927024682 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927024683 nucleotide binding region [chemical binding]; other site 749927024684 ATP-binding site [chemical binding]; other site 749927024685 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 749927024686 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 749927024687 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 749927024688 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 749927024689 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 749927024690 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 749927024691 Walker A motif; other site 749927024692 ATP binding site [chemical binding]; other site 749927024693 Walker B motif; other site 749927024694 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 749927024695 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 749927024696 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 749927024697 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 749927024698 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 749927024699 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 749927024700 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927024701 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 749927024702 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 749927024703 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 749927024704 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 749927024705 putative active site [active] 749927024706 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 749927024707 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 749927024708 putative active site [active] 749927024709 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 749927024710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927024711 active site 749927024712 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927024713 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927024714 acetyl-CoA synthetase; Provisional; Region: PRK00174 749927024715 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 749927024716 active site 749927024717 CoA binding site [chemical binding]; other site 749927024718 acyl-activating enzyme (AAE) consensus motif; other site 749927024719 AMP binding site [chemical binding]; other site 749927024720 acetate binding site [chemical binding]; other site 749927024721 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 749927024722 Cupin domain; Region: Cupin_2; pfam07883 749927024723 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 749927024724 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 749927024725 POT family; Region: PTR2; cl17359 749927024726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927024727 putative substrate translocation pore; other site 749927024728 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 749927024729 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 749927024730 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927024731 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927024732 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927024733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927024734 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 749927024735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927024736 DNA-binding site [nucleotide binding]; DNA binding site 749927024737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927024738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927024739 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 749927024740 Colicin V production protein; Region: Colicin_V; pfam02674 749927024741 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 749927024742 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 749927024743 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 749927024744 putative active site [active] 749927024745 putative CoA binding site [chemical binding]; other site 749927024746 nudix motif; other site 749927024747 metal binding site [ion binding]; metal-binding site 749927024748 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 749927024749 catalytic residues [active] 749927024750 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 749927024751 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 749927024752 minor groove reading motif; other site 749927024753 helix-hairpin-helix signature motif; other site 749927024754 substrate binding pocket [chemical binding]; other site 749927024755 active site 749927024756 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 749927024757 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 749927024758 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 749927024759 ligand binding site [chemical binding]; other site 749927024760 flexible hinge region; other site 749927024761 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 749927024762 putative switch regulator; other site 749927024763 non-specific DNA interactions [nucleotide binding]; other site 749927024764 DNA binding site [nucleotide binding] 749927024765 sequence specific DNA binding site [nucleotide binding]; other site 749927024766 putative cAMP binding site [chemical binding]; other site 749927024767 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 749927024768 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 749927024769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927024770 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927024771 putative substrate translocation pore; other site 749927024772 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 749927024773 DNA polymerase III subunit beta; Validated; Region: PRK07761 749927024774 putative DNA binding surface [nucleotide binding]; other site 749927024775 dimer interface [polypeptide binding]; other site 749927024776 beta-clamp/clamp loader binding surface; other site 749927024777 beta-clamp/translesion DNA polymerase binding surface; other site 749927024778 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927024779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927024780 AsnC family; Region: AsnC_trans_reg; pfam01037 749927024781 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927024782 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 749927024783 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 749927024784 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 749927024785 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 749927024786 substrate binding pocket [chemical binding]; other site 749927024787 catalytic triad [active] 749927024788 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749927024789 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 749927024790 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 749927024791 nudix motif; other site 749927024792 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 749927024793 homotrimer interaction site [polypeptide binding]; other site 749927024794 putative active site [active] 749927024795 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 749927024796 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927024797 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 749927024798 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 749927024799 Transcription factor WhiB; Region: Whib; pfam02467 749927024800 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 749927024801 Transglycosylase; Region: Transgly; pfam00912 749927024802 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 749927024803 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927024804 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927024805 active site 749927024806 ATP binding site [chemical binding]; other site 749927024807 substrate binding site [chemical binding]; other site 749927024808 activation loop (A-loop); other site 749927024809 Fungal domain of unknown function (DUF1750); Region: SWI-SNF_Ssr4; pfam08549 749927024810 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 749927024811 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 749927024812 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 749927024813 putative active site [active] 749927024814 putative metal binding site [ion binding]; other site 749927024815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927024816 S-adenosylmethionine binding site [chemical binding]; other site 749927024817 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 749927024818 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 749927024819 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 749927024820 active site 1 [active] 749927024821 dimer interface [polypeptide binding]; other site 749927024822 hexamer interface [polypeptide binding]; other site 749927024823 active site 2 [active] 749927024824 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 749927024825 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 749927024826 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 749927024827 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 749927024828 DinB superfamily; Region: DinB_2; cl19195 749927024829 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 749927024830 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 749927024831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927024832 catalytic residue [active] 749927024833 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 749927024834 Ferritin-like domain; Region: Ferritin; pfam00210 749927024835 dimerization interface [polypeptide binding]; other site 749927024836 DPS ferroxidase diiron center [ion binding]; other site 749927024837 ion pore; other site 749927024838 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 749927024839 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 749927024840 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 749927024841 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 749927024842 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 749927024843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927024844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927024845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927024846 putative substrate translocation pore; other site 749927024847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927024848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927024849 putative substrate translocation pore; other site 749927024850 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 749927024851 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 749927024852 Peptidase family M48; Region: Peptidase_M48; cl12018 749927024853 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 749927024854 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 749927024855 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 749927024856 aspartate kinase; Reviewed; Region: PRK06635 749927024857 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 749927024858 putative nucleotide binding site [chemical binding]; other site 749927024859 putative catalytic residues [active] 749927024860 putative Mg ion binding site [ion binding]; other site 749927024861 putative aspartate binding site [chemical binding]; other site 749927024862 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 749927024863 putative allosteric regulatory site; other site 749927024864 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 749927024865 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 749927024866 FMN binding site [chemical binding]; other site 749927024867 dimer interface [polypeptide binding]; other site 749927024868 2-isopropylmalate synthase; Validated; Region: PRK03739 749927024869 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 749927024870 active site 749927024871 catalytic residues [active] 749927024872 metal binding site [ion binding]; metal-binding site 749927024873 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 749927024874 Predicted transcriptional regulator [Transcription]; Region: COG2378 749927024875 HTH domain; Region: HTH_11; pfam08279 749927024876 WYL domain; Region: WYL; pfam13280 749927024877 short chain dehydrogenase; Provisional; Region: PRK08303 749927024878 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 749927024879 NAD(P) binding site [chemical binding]; other site 749927024880 active site 749927024881 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 749927024882 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 749927024883 putative catalytic residues [active] 749927024884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927024885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927024886 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 749927024887 Transcriptional regulator [Transcription]; Region: LysR; COG0583 749927024888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 749927024889 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 749927024890 dimerization interface [polypeptide binding]; other site 749927024891 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 749927024892 EamA-like transporter family; Region: EamA; pfam00892 749927024893 EamA-like transporter family; Region: EamA; pfam00892 749927024894 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 749927024895 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 749927024896 YCII-related domain; Region: YCII; cl00999 749927024897 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927024898 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927024899 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927024900 DNA binding residues [nucleotide binding] 749927024901 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 749927024902 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927024903 Walker A/P-loop; other site 749927024904 ATP binding site [chemical binding]; other site 749927024905 Q-loop/lid; other site 749927024906 ABC transporter signature motif; other site 749927024907 Walker B; other site 749927024908 D-loop; other site 749927024909 H-loop/switch region; other site 749927024910 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927024911 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 749927024912 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 749927024913 Walker A/P-loop; other site 749927024914 ATP binding site [chemical binding]; other site 749927024915 Q-loop/lid; other site 749927024916 ABC transporter signature motif; other site 749927024917 Walker B; other site 749927024918 D-loop; other site 749927024919 H-loop/switch region; other site 749927024920 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 749927024921 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 749927024922 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 749927024923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927024924 dimer interface [polypeptide binding]; other site 749927024925 conserved gate region; other site 749927024926 putative PBP binding loops; other site 749927024927 ABC-ATPase subunit interface; other site 749927024928 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 749927024929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927024930 dimer interface [polypeptide binding]; other site 749927024931 conserved gate region; other site 749927024932 putative PBP binding loops; other site 749927024933 ABC-ATPase subunit interface; other site 749927024934 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 749927024935 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 749927024936 peptide binding site [polypeptide binding]; other site 749927024937 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 749927024938 Ligand binding site; other site 749927024939 Putative Catalytic site; other site 749927024940 DXD motif; other site 749927024941 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 749927024942 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 749927024943 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 749927024944 active site 749927024945 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 749927024946 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 749927024947 recombination protein RecR; Reviewed; Region: recR; PRK00076 749927024948 Helix-hairpin-helix motif; Region: HHH; pfam00633 749927024949 RecR protein; Region: RecR; pfam02132 749927024950 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 749927024951 putative active site [active] 749927024952 putative metal-binding site [ion binding]; other site 749927024953 tetramer interface [polypeptide binding]; other site 749927024954 hypothetical protein; Validated; Region: PRK00153 749927024955 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 749927024956 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 749927024957 active site 749927024958 metal binding site [ion binding]; metal-binding site 749927024959 Predicted transcriptional regulators [Transcription]; Region: COG1733 749927024960 dimerization interface [polypeptide binding]; other site 749927024961 putative DNA binding site [nucleotide binding]; other site 749927024962 putative Zn2+ binding site [ion binding]; other site 749927024963 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927024964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 749927024965 HTH-like domain; Region: HTH_21; pfam13276 749927024966 Integrase core domain; Region: rve; pfam00665 749927024967 Integrase core domain; Region: rve_3; pfam13683 749927024968 Transposase; Region: HTH_Tnp_1; cl17663 749927024969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 749927024970 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 749927024971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927024972 Walker A motif; other site 749927024973 ATP binding site [chemical binding]; other site 749927024974 Walker B motif; other site 749927024975 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 749927024976 Short repeats of unknown function; Region: ALF; pfam03752 749927024977 Short repeats of unknown function; Region: ALF; pfam03752 749927024978 Short repeats of unknown function; Region: ALF; pfam03752 749927024979 Short repeats of unknown function; Region: ALF; pfam03752 749927024980 Short repeats of unknown function; Region: ALF; pfam03752 749927024981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927024982 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 749927024983 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 749927024984 G1 box; other site 749927024985 GTP/Mg2+ binding site [chemical binding]; other site 749927024986 G2 box; other site 749927024987 Switch I region; other site 749927024988 G3 box; other site 749927024989 Switch II region; other site 749927024990 G4 box; other site 749927024991 G5 box; other site 749927024992 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927024993 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 749927024994 Nitrate and nitrite sensing; Region: NIT; pfam08376 749927024995 HAMP domain; Region: HAMP; pfam00672 749927024996 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927024997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927024998 ATP binding site [chemical binding]; other site 749927024999 Mg2+ binding site [ion binding]; other site 749927025000 G-X-G motif; other site 749927025001 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 749927025002 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 749927025003 Walker A/P-loop; other site 749927025004 ATP binding site [chemical binding]; other site 749927025005 Q-loop/lid; other site 749927025006 ABC transporter signature motif; other site 749927025007 Walker B; other site 749927025008 D-loop; other site 749927025009 H-loop/switch region; other site 749927025010 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 749927025011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927025012 dimer interface [polypeptide binding]; other site 749927025013 conserved gate region; other site 749927025014 putative PBP binding loops; other site 749927025015 ABC-ATPase subunit interface; other site 749927025016 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 749927025017 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 749927025018 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 749927025019 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 749927025020 HAMP domain; Region: HAMP; pfam00672 749927025021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 749927025022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 749927025023 dimer interface [polypeptide binding]; other site 749927025024 phosphorylation site [posttranslational modification] 749927025025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927025026 ATP binding site [chemical binding]; other site 749927025027 Mg2+ binding site [ion binding]; other site 749927025028 G-X-G motif; other site 749927025029 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 749927025030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927025031 active site 749927025032 phosphorylation site [posttranslational modification] 749927025033 intermolecular recognition site; other site 749927025034 dimerization interface [polypeptide binding]; other site 749927025035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927025036 DNA binding site [nucleotide binding] 749927025037 Histidine kinase; Region: HisKA_3; pfam07730 749927025038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927025039 Mg2+ binding site [ion binding]; other site 749927025040 G-X-G motif; other site 749927025041 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927025042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927025043 active site 749927025044 phosphorylation site [posttranslational modification] 749927025045 intermolecular recognition site; other site 749927025046 dimerization interface [polypeptide binding]; other site 749927025047 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927025048 DNA binding residues [nucleotide binding] 749927025049 dimerization interface [polypeptide binding]; other site 749927025050 Domain of unknown function (DUF385); Region: DUF385; cl04387 749927025051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927025052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927025053 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 749927025054 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927025055 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927025056 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927025057 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 749927025058 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 749927025059 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 749927025060 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 749927025061 LGFP repeat; Region: LGFP; pfam08310 749927025062 LGFP repeat; Region: LGFP; pfam08310 749927025063 LGFP repeat; Region: LGFP; pfam08310 749927025064 LGFP repeat; Region: LGFP; pfam08310 749927025065 LGFP repeat; Region: LGFP; pfam08310 749927025066 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 749927025067 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 749927025068 Catalytic domain of Protein Kinases; Region: PKc; cd00180 749927025069 active site 749927025070 ATP binding site [chemical binding]; other site 749927025071 substrate binding site [chemical binding]; other site 749927025072 activation loop (A-loop); other site 749927025073 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 749927025074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927025075 S-adenosylmethionine binding site [chemical binding]; other site 749927025076 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 749927025077 active site 749927025078 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 749927025079 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 749927025080 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 749927025081 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 749927025082 generic binding surface I; other site 749927025083 generic binding surface II; other site 749927025084 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 749927025085 putative active site [active] 749927025086 putative catalytic site [active] 749927025087 putative Mg binding site IVb [ion binding]; other site 749927025088 putative phosphate binding site [ion binding]; other site 749927025089 putative DNA binding site [nucleotide binding]; other site 749927025090 putative Mg binding site IVa [ion binding]; other site 749927025091 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 749927025092 putative active site [active] 749927025093 putative metal binding site [ion binding]; other site 749927025094 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 749927025095 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 749927025096 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 749927025097 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 749927025098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927025099 NAD(P) binding site [chemical binding]; other site 749927025100 active site 749927025101 CsbD-like; Region: CsbD; pfam05532 749927025102 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 749927025103 nucleoside/Zn binding site; other site 749927025104 dimer interface [polypeptide binding]; other site 749927025105 catalytic motif [active] 749927025106 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 749927025107 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 749927025108 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 749927025109 metal binding site [ion binding]; metal-binding site 749927025110 dimer interface [polypeptide binding]; other site 749927025111 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 749927025112 Phosphoesterase family; Region: Phosphoesterase; pfam04185 749927025113 Domain of unknown function (DUF756); Region: DUF756; pfam05506 749927025114 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 749927025115 active site 749927025116 Domain of unknown function (DUF336); Region: DUF336; cl01249 749927025117 RibD C-terminal domain; Region: RibD_C; cl17279 749927025118 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 749927025119 active site 749927025120 dimer interface [polypeptide binding]; other site 749927025121 motif 1; other site 749927025122 motif 2; other site 749927025123 motif 3; other site 749927025124 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 749927025125 anticodon binding site; other site 749927025126 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 749927025127 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927025128 DNA binding residues [nucleotide binding] 749927025129 dimer interface [polypeptide binding]; other site 749927025130 Beta protein; Region: Beta_protein; pfam14350 749927025131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927025132 dimer interface [polypeptide binding]; other site 749927025133 conserved gate region; other site 749927025134 putative PBP binding loops; other site 749927025135 ABC-ATPase subunit interface; other site 749927025136 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 749927025137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927025138 dimer interface [polypeptide binding]; other site 749927025139 conserved gate region; other site 749927025140 putative PBP binding loops; other site 749927025141 ABC-ATPase subunit interface; other site 749927025142 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 749927025143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927025144 Walker A/P-loop; other site 749927025145 ATP binding site [chemical binding]; other site 749927025146 Q-loop/lid; other site 749927025147 ABC transporter signature motif; other site 749927025148 Walker B; other site 749927025149 D-loop; other site 749927025150 H-loop/switch region; other site 749927025151 TOBE domain; Region: TOBE_2; pfam08402 749927025152 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 749927025153 Transcriptional regulators [Transcription]; Region: GntR; COG1802 749927025154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927025155 DNA-binding site [nucleotide binding]; DNA binding site 749927025156 FCD domain; Region: FCD; pfam07729 749927025157 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 749927025158 inhibitor site; inhibition site 749927025159 active site 749927025160 dimer interface [polypeptide binding]; other site 749927025161 catalytic residue [active] 749927025162 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 749927025163 putative di-iron ligands [ion binding]; other site 749927025164 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 749927025165 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 749927025166 active site 749927025167 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 749927025168 substrate binding site [chemical binding]; other site 749927025169 catalytic residues [active] 749927025170 dimer interface [polypeptide binding]; other site 749927025171 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 749927025172 dimerization interface [polypeptide binding]; other site 749927025173 putative DNA binding site [nucleotide binding]; other site 749927025174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927025175 putative Zn2+ binding site [ion binding]; other site 749927025176 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 749927025177 Part of AAA domain; Region: AAA_19; pfam13245 749927025178 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 749927025179 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 749927025180 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 749927025181 active site 749927025182 metal binding site [ion binding]; metal-binding site 749927025183 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 749927025184 intermolecular salt bridges; other site 749927025185 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 749927025186 active site 749927025187 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 749927025188 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 749927025189 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927025190 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927025191 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 749927025192 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 749927025193 FMN binding site [chemical binding]; other site 749927025194 active site 749927025195 catalytic residues [active] 749927025196 substrate binding site [chemical binding]; other site 749927025197 alpha-galactosidase; Region: PLN02808; cl17638 749927025198 alpha-galactosidase; Region: PLN02808; cl17638 749927025199 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 749927025200 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 749927025201 putative sugar binding sites [chemical binding]; other site 749927025202 Q-X-W motif; other site 749927025203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927025204 DNA-binding site [nucleotide binding]; DNA binding site 749927025205 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 749927025206 UTRA domain; Region: UTRA; cl17743 749927025207 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 749927025208 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 749927025209 substrate binding site [chemical binding]; other site 749927025210 ATP binding site [chemical binding]; other site 749927025211 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 749927025212 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 749927025213 catalytic triad [active] 749927025214 conserved cis-peptide bond; other site 749927025215 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 749927025216 Putative lysophospholipase; Region: Hydrolase_4; cl19140 749927025217 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 749927025218 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 749927025219 active site 749927025220 metal binding site [ion binding]; metal-binding site 749927025221 nudix motif; other site 749927025222 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927025223 metal binding site [ion binding]; metal-binding site 749927025224 active site 749927025225 I-site; other site 749927025226 Transcriptional regulator [Transcription]; Region: LytR; COG1316 749927025227 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 749927025228 PhoU domain; Region: PhoU; pfam01895 749927025229 PhoU domain; Region: PhoU; pfam01895 749927025230 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 749927025231 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 749927025232 Walker A/P-loop; other site 749927025233 ATP binding site [chemical binding]; other site 749927025234 Q-loop/lid; other site 749927025235 ABC transporter signature motif; other site 749927025236 Walker B; other site 749927025237 D-loop; other site 749927025238 H-loop/switch region; other site 749927025239 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 749927025240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927025241 dimer interface [polypeptide binding]; other site 749927025242 conserved gate region; other site 749927025243 putative PBP binding loops; other site 749927025244 ABC-ATPase subunit interface; other site 749927025245 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 749927025246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927025247 dimer interface [polypeptide binding]; other site 749927025248 conserved gate region; other site 749927025249 putative PBP binding loops; other site 749927025250 ABC-ATPase subunit interface; other site 749927025251 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 749927025252 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 749927025253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927025254 Coenzyme A binding pocket [chemical binding]; other site 749927025255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927025256 Coenzyme A binding pocket [chemical binding]; other site 749927025257 DNA-binding response regulator CreB; Provisional; Region: PRK11083 749927025258 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 749927025259 DNA binding site [nucleotide binding] 749927025260 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 749927025261 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 749927025262 catalytic residues [active] 749927025263 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 749927025264 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 749927025265 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 749927025266 active site residue [active] 749927025267 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 749927025268 active site residue [active] 749927025269 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 749927025270 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 749927025271 heme-binding site [chemical binding]; other site 749927025272 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 749927025273 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 749927025274 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07849 749927025275 homodimer interface [polypeptide binding]; other site 749927025276 substrate-cofactor binding pocket; other site 749927025277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927025278 catalytic residue [active] 749927025279 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 749927025280 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 749927025281 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 749927025282 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 749927025283 L-asparaginase II; Region: Asparaginase_II; pfam06089 749927025284 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 749927025285 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 749927025286 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 749927025287 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 749927025288 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 749927025289 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 749927025290 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 749927025291 Walker A/P-loop; other site 749927025292 ATP binding site [chemical binding]; other site 749927025293 Q-loop/lid; other site 749927025294 ABC transporter signature motif; other site 749927025295 Walker B; other site 749927025296 D-loop; other site 749927025297 H-loop/switch region; other site 749927025298 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 749927025299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927025300 Walker A/P-loop; other site 749927025301 ATP binding site [chemical binding]; other site 749927025302 Q-loop/lid; other site 749927025303 ABC transporter signature motif; other site 749927025304 Walker B; other site 749927025305 D-loop; other site 749927025306 H-loop/switch region; other site 749927025307 Cobalt transport protein; Region: CbiQ; cl00463 749927025308 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927025309 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927025310 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927025311 VanZ like family; Region: VanZ; cl01971 749927025312 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927025313 Coenzyme A binding pocket [chemical binding]; other site 749927025314 hypothetical protein; Provisional; Region: PRK09256 749927025315 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 749927025316 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 749927025317 dimerization interface [polypeptide binding]; other site 749927025318 putative ATP binding site [chemical binding]; other site 749927025319 amidophosphoribosyltransferase; Provisional; Region: PRK07847 749927025320 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 749927025321 active site 749927025322 tetramer interface [polypeptide binding]; other site 749927025323 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927025324 active site 749927025325 Domain of unknown function (DUF397); Region: DUF397; pfam04149 749927025326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927025327 non-specific DNA binding site [nucleotide binding]; other site 749927025328 salt bridge; other site 749927025329 sequence-specific DNA binding site [nucleotide binding]; other site 749927025330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927025331 SseB protein N-terminal domain; Region: SseB; pfam07179 749927025332 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 749927025333 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 749927025334 active site 749927025335 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 749927025336 active site 749927025337 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 749927025338 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 749927025339 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 749927025340 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 749927025341 Helix-turn-helix domain; Region: HTH_38; pfam13936 749927025342 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 749927025343 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 749927025344 dimerization interface [polypeptide binding]; other site 749927025345 ATP binding site [chemical binding]; other site 749927025346 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 749927025347 dimerization interface [polypeptide binding]; other site 749927025348 ATP binding site [chemical binding]; other site 749927025349 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927025350 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927025351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927025352 Walker A/P-loop; other site 749927025353 ATP binding site [chemical binding]; other site 749927025354 Q-loop/lid; other site 749927025355 ABC transporter signature motif; other site 749927025356 Walker B; other site 749927025357 D-loop; other site 749927025358 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927025359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927025360 Walker A/P-loop; other site 749927025361 ATP binding site [chemical binding]; other site 749927025362 Q-loop/lid; other site 749927025363 ABC transporter signature motif; other site 749927025364 Walker B; other site 749927025365 D-loop; other site 749927025366 H-loop/switch region; other site 749927025367 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 749927025368 putative active site [active] 749927025369 catalytic triad [active] 749927025370 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 749927025371 choline dehydrogenase; Validated; Region: PRK02106 749927025372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927025373 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 749927025374 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 749927025375 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 749927025376 NAD(P) binding site [chemical binding]; other site 749927025377 catalytic residues [active] 749927025378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927025379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927025380 putative substrate translocation pore; other site 749927025381 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 749927025382 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 749927025383 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 749927025384 Predicted flavoprotein [General function prediction only]; Region: COG0431 749927025385 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 749927025386 ATP binding site [chemical binding]; other site 749927025387 active site 749927025388 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 749927025389 substrate binding site [chemical binding]; other site 749927025390 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 749927025391 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 749927025392 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 749927025393 Walker A/P-loop; other site 749927025394 ATP binding site [chemical binding]; other site 749927025395 Q-loop/lid; other site 749927025396 ABC transporter signature motif; other site 749927025397 Walker B; other site 749927025398 D-loop; other site 749927025399 H-loop/switch region; other site 749927025400 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 749927025401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927025402 dimer interface [polypeptide binding]; other site 749927025403 conserved gate region; other site 749927025404 putative PBP binding loops; other site 749927025405 ABC-ATPase subunit interface; other site 749927025406 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749927025407 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749927025408 substrate binding pocket [chemical binding]; other site 749927025409 membrane-bound complex binding site; other site 749927025410 hinge residues; other site 749927025411 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749927025412 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749927025413 substrate binding pocket [chemical binding]; other site 749927025414 membrane-bound complex binding site; other site 749927025415 hinge residues; other site 749927025416 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749927025417 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749927025418 substrate binding pocket [chemical binding]; other site 749927025419 membrane-bound complex binding site; other site 749927025420 hinge residues; other site 749927025421 adenylosuccinate lyase; Region: purB; TIGR00928 749927025422 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 749927025423 tetramer interface [polypeptide binding]; other site 749927025424 galactonate dehydratase; Provisional; Region: PRK14017 749927025425 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 749927025426 metal binding site [ion binding]; metal-binding site 749927025427 substrate binding pocket [chemical binding]; other site 749927025428 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 749927025429 classical (c) SDRs; Region: SDR_c; cd05233 749927025430 NAD(P) binding site [chemical binding]; other site 749927025431 active site 749927025432 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 749927025433 Transcriptional regulators [Transcription]; Region: FadR; COG2186 749927025434 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 749927025435 DNA-binding site [nucleotide binding]; DNA binding site 749927025436 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 749927025437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 749927025438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927025439 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927025440 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927025441 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927025442 DNA binding residues [nucleotide binding] 749927025443 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 749927025444 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 749927025445 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 749927025446 catalytic residue [active] 749927025447 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 749927025448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927025449 motif II; other site 749927025450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927025451 aspartate aminotransferase; Provisional; Region: PRK05764 749927025452 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927025453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927025454 homodimer interface [polypeptide binding]; other site 749927025455 catalytic residue [active] 749927025456 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 749927025457 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 749927025458 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 749927025459 N-acetyl-D-glucosamine binding site [chemical binding]; other site 749927025460 catalytic residue [active] 749927025461 EspG family; Region: ESX-1_EspG; pfam14011 749927025462 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 749927025463 septum formation inhibitor; Reviewed; Region: minC; PRK03511 749927025464 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 749927025465 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 749927025466 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 749927025467 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 749927025468 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 749927025469 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 749927025470 putative active site [active] 749927025471 catalytic site [active] 749927025472 putative metal binding site [ion binding]; other site 749927025473 Beta-lactamase; Region: Beta-lactamase; pfam00144 749927025474 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 749927025475 Amino acid permease; Region: AA_permease_2; pfam13520 749927025476 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 749927025477 ligand binding site [chemical binding]; other site 749927025478 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 749927025479 substrate binding site [chemical binding]; other site 749927025480 ATP binding site [chemical binding]; other site 749927025481 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522 749927025482 dimerization interface [polypeptide binding]; other site 749927025483 active site 749927025484 benzoate transport; Region: 2A0115; TIGR00895 749927025485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927025486 putative substrate translocation pore; other site 749927025487 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 749927025488 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 749927025489 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927025490 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 749927025491 OsmC-like protein; Region: OsmC; pfam02566 749927025492 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 749927025493 GDP-binding site [chemical binding]; other site 749927025494 ACT binding site; other site 749927025495 IMP binding site; other site 749927025496 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 749927025497 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 749927025498 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 749927025499 homodimer interface [polypeptide binding]; other site 749927025500 active site 749927025501 TDP-binding site; other site 749927025502 acceptor substrate-binding pocket; other site 749927025503 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 749927025504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927025505 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927025506 putative substrate translocation pore; other site 749927025507 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 749927025508 metal binding site [ion binding]; metal-binding site 749927025509 active site 749927025510 I-site; other site 749927025511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927025512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927025513 Secretory lipase; Region: LIP; pfam03583 749927025514 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 749927025515 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 749927025516 active site 749927025517 intersubunit interface [polypeptide binding]; other site 749927025518 zinc binding site [ion binding]; other site 749927025519 Na+ binding site [ion binding]; other site 749927025520 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 749927025521 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 749927025522 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 749927025523 active site 749927025524 catalytic tetrad [active] 749927025525 short chain dehydrogenase; Provisional; Region: PRK05872 749927025526 classical (c) SDRs; Region: SDR_c; cd05233 749927025527 NAD(P) binding site [chemical binding]; other site 749927025528 active site 749927025529 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 749927025530 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 749927025531 Predicted metal-dependent hydrolase; Region: Metal_hydrol; cl19844 749927025532 potential frameshift: common BLAST hit: gi|134100094|ref|YP_001105755.1| phthalate 4,5-dioxygenase 749927025533 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 749927025534 FMN-binding pocket [chemical binding]; other site 749927025535 flavin binding motif; other site 749927025536 phosphate binding motif [ion binding]; other site 749927025537 beta-alpha-beta structure motif; other site 749927025538 NAD binding pocket [chemical binding]; other site 749927025539 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 749927025540 catalytic loop [active] 749927025541 iron binding site [ion binding]; other site 749927025542 YCII-related domain; Region: YCII; cl00999 749927025543 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927025544 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927025545 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927025546 DNA binding residues [nucleotide binding] 749927025547 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 749927025548 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 749927025549 active site 749927025550 dimer interface [polypeptide binding]; other site 749927025551 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 749927025552 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 749927025553 putative active site [active] 749927025554 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 749927025555 FAD binding domain; Region: FAD_binding_4; pfam01565 749927025556 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 749927025557 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 749927025558 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 749927025559 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927025560 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927025561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927025562 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 749927025563 putative substrate translocation pore; other site 749927025564 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 749927025565 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 749927025566 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 749927025567 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 749927025568 YceI-like domain; Region: YceI; pfam04264 749927025569 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 749927025570 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 749927025571 active site 749927025572 metal binding site [ion binding]; metal-binding site 749927025573 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 749927025574 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 749927025575 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 749927025576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 749927025577 classical (c) SDRs; Region: SDR_c; cd05233 749927025578 NAD(P) binding site [chemical binding]; other site 749927025579 active site 749927025580 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 749927025581 active site 749927025582 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 749927025583 substrate binding site [chemical binding]; other site 749927025584 ATP binding site [chemical binding]; other site 749927025585 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 749927025586 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 749927025587 Walker A/P-loop; other site 749927025588 ATP binding site [chemical binding]; other site 749927025589 Q-loop/lid; other site 749927025590 ABC transporter signature motif; other site 749927025591 Walker B; other site 749927025592 D-loop; other site 749927025593 H-loop/switch region; other site 749927025594 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 749927025595 TM-ABC transporter signature motif; other site 749927025596 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 749927025597 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 749927025598 ligand binding site [chemical binding]; other site 749927025599 Transcriptional regulators [Transcription]; Region: PurR; COG1609 749927025600 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 749927025601 DNA binding site [nucleotide binding] 749927025602 domain linker motif; other site 749927025603 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927025604 ligand binding site [chemical binding]; other site 749927025605 dimerization interface [polypeptide binding]; other site 749927025606 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 749927025607 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 749927025608 ligand binding site [chemical binding]; other site 749927025609 dimerization interface [polypeptide binding]; other site 749927025610 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 749927025611 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 749927025612 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 749927025613 molybdopterin cofactor binding site; other site 749927025614 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 749927025615 molybdopterin cofactor binding site; other site 749927025616 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 749927025617 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 749927025618 Asp23 family; Region: Asp23; pfam03780 749927025619 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 749927025620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927025621 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927025622 DNA binding residues [nucleotide binding] 749927025623 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 749927025624 active site 749927025625 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 749927025626 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 749927025627 FtsX-like permease family; Region: FtsX; pfam02687 749927025628 FtsX-like permease family; Region: FtsX; pfam02687 749927025629 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 749927025630 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 749927025631 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 749927025632 Walker A/P-loop; other site 749927025633 ATP binding site [chemical binding]; other site 749927025634 Q-loop/lid; other site 749927025635 ABC transporter signature motif; other site 749927025636 Walker B; other site 749927025637 D-loop; other site 749927025638 H-loop/switch region; other site 749927025639 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 749927025640 classical (c) SDRs; Region: SDR_c; cd05233 749927025641 NAD(P) binding site [chemical binding]; other site 749927025642 active site 749927025643 anthranilate synthase; Provisional; Region: PRK13566 749927025644 Clp amino terminal domain; Region: Clp_N; pfam02861 749927025645 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 749927025646 Clp amino terminal domain; Region: Clp_N; pfam02861 749927025647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927025648 Walker A motif; other site 749927025649 ATP binding site [chemical binding]; other site 749927025650 Walker B motif; other site 749927025651 arginine finger; other site 749927025652 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 749927025653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 749927025654 Walker A motif; other site 749927025655 ATP binding site [chemical binding]; other site 749927025656 Walker B motif; other site 749927025657 arginine finger; other site 749927025658 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 749927025659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927025660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927025661 putative substrate translocation pore; other site 749927025662 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927025663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927025664 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 749927025665 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 749927025666 heme-binding site [chemical binding]; other site 749927025667 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 749927025668 FAD binding pocket [chemical binding]; other site 749927025669 FAD binding motif [chemical binding]; other site 749927025670 phosphate binding motif [ion binding]; other site 749927025671 beta-alpha-beta structure motif; other site 749927025672 NAD binding pocket [chemical binding]; other site 749927025673 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 749927025674 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 749927025675 heme-binding site [chemical binding]; other site 749927025676 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 749927025677 FAD binding pocket [chemical binding]; other site 749927025678 FAD binding motif [chemical binding]; other site 749927025679 phosphate binding motif [ion binding]; other site 749927025680 beta-alpha-beta structure motif; other site 749927025681 NAD binding pocket [chemical binding]; other site 749927025682 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 749927025683 Chitin binding domain; Region: Chitin_bind_3; pfam03067 749927025684 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 749927025685 Domain of unknown function (DUF305); Region: DUF305; cl17794 749927025686 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 749927025687 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927025688 DNA binding residues [nucleotide binding] 749927025689 putative dimer interface [polypeptide binding]; other site 749927025690 chaperone protein DnaJ; Provisional; Region: PRK14279 749927025691 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 749927025692 HSP70 interaction site [polypeptide binding]; other site 749927025693 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 749927025694 Zn binding sites [ion binding]; other site 749927025695 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 749927025696 dimer interface [polypeptide binding]; other site 749927025697 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 749927025698 dimer interface [polypeptide binding]; other site 749927025699 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 749927025700 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 749927025701 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 749927025702 nucleotide binding site [chemical binding]; other site 749927025703 NEF interaction site [polypeptide binding]; other site 749927025704 SBD interface [polypeptide binding]; other site 749927025705 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 749927025706 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 749927025707 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 749927025708 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 749927025709 substrate binding site [chemical binding]; other site 749927025710 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 749927025711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927025712 non-specific DNA binding site [nucleotide binding]; other site 749927025713 salt bridge; other site 749927025714 sequence-specific DNA binding site [nucleotide binding]; other site 749927025715 Domain of unknown function (DUF397); Region: DUF397; pfam04149 749927025716 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 749927025717 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927025718 Coenzyme A binding pocket [chemical binding]; other site 749927025719 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 749927025720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927025721 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 749927025722 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 749927025723 Cysteine-rich domain; Region: CCG; pfam02754 749927025724 Cysteine-rich domain; Region: CCG; pfam02754 749927025725 Protein of unknown function (DUF742); Region: DUF742; pfam05331 749927025726 Cation efflux family; Region: Cation_efflux; pfam01545 749927025727 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 749927025728 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 749927025729 Domain of unknown function DUF11; Region: DUF11; cl17728 749927025730 Domain of unknown function DUF11; Region: DUF11; pfam01345 749927025731 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927025732 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 749927025733 dimerization interface [polypeptide binding]; other site 749927025734 putative Zn2+ binding site [ion binding]; other site 749927025735 putative DNA binding site [nucleotide binding]; other site 749927025736 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 749927025737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927025738 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 749927025739 trimer interface [polypeptide binding]; other site 749927025740 active site 749927025741 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 749927025742 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 749927025743 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 749927025744 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927025745 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 749927025746 YCII-related domain; Region: YCII; cl00999 749927025747 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 749927025748 Domain of unknown function (DUF385); Region: DUF385; cl04387 749927025749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 749927025750 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927025751 YjbR; Region: YjbR; cl15265 749927025752 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 749927025753 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 749927025754 putative active site [active] 749927025755 putative metal binding site [ion binding]; other site 749927025756 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 749927025757 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 749927025758 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 749927025759 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927025760 VanZ like family; Region: VanZ; cl01971 749927025761 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 749927025762 active site 749927025763 SUMO-1 interface [polypeptide binding]; other site 749927025764 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927025765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927025766 DNA binding residues [nucleotide binding] 749927025767 dimerization interface [polypeptide binding]; other site 749927025768 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 749927025769 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 749927025770 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 749927025771 active site 749927025772 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 749927025773 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 749927025774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927025775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927025776 putative substrate translocation pore; other site 749927025777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927025778 salt bridge; other site 749927025779 non-specific DNA binding site [nucleotide binding]; other site 749927025780 sequence-specific DNA binding site [nucleotide binding]; other site 749927025781 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 749927025782 Leucine rich repeat; Region: LRR_8; pfam13855 749927025783 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 749927025784 Leucine-rich repeats; other site 749927025785 Substrate binding site [chemical binding]; other site 749927025786 Leucine rich repeat; Region: LRR_8; pfam13855 749927025787 Leucine rich repeat; Region: LRR_8; pfam13855 749927025788 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 749927025789 VanW like protein; Region: VanW; pfam04294 749927025790 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 749927025791 oligomerisation interface [polypeptide binding]; other site 749927025792 mobile loop; other site 749927025793 roof hairpin; other site 749927025794 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 749927025795 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 749927025796 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 749927025797 hydrophobic ligand binding site; other site 749927025798 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 749927025799 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 749927025800 Walker A/P-loop; other site 749927025801 ATP binding site [chemical binding]; other site 749927025802 Q-loop/lid; other site 749927025803 ABC transporter signature motif; other site 749927025804 Walker B; other site 749927025805 D-loop; other site 749927025806 H-loop/switch region; other site 749927025807 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 749927025808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 749927025809 dimer interface [polypeptide binding]; other site 749927025810 conserved gate region; other site 749927025811 putative PBP binding loops; other site 749927025812 ABC-ATPase subunit interface; other site 749927025813 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 749927025814 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 749927025815 substrate binding pocket [chemical binding]; other site 749927025816 membrane-bound complex binding site; other site 749927025817 hinge residues; other site 749927025818 Uncharacterized conserved protein [Function unknown]; Region: COG2308 749927025819 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl19824 749927025820 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 749927025821 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 749927025822 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 749927025823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927025824 NAD(P) binding site [chemical binding]; other site 749927025825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927025826 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 749927025827 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 749927025828 metal binding site [ion binding]; metal-binding site 749927025829 putative dimer interface [polypeptide binding]; other site 749927025830 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 749927025831 TPP-binding site [chemical binding]; other site 749927025832 heterodimer interface [polypeptide binding]; other site 749927025833 tetramer interface [polypeptide binding]; other site 749927025834 phosphorylation loop region [posttranslational modification] 749927025835 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 749927025836 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 749927025837 alpha subunit interface [polypeptide binding]; other site 749927025838 TPP binding site [chemical binding]; other site 749927025839 heterodimer interface [polypeptide binding]; other site 749927025840 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 749927025841 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 749927025842 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 749927025843 E3 interaction surface; other site 749927025844 lipoyl attachment site [posttranslational modification]; other site 749927025845 e3 binding domain; Region: E3_binding; pfam02817 749927025846 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 749927025847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927025848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927025849 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 749927025850 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 749927025851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927025852 Walker A/P-loop; other site 749927025853 ATP binding site [chemical binding]; other site 749927025854 Q-loop/lid; other site 749927025855 ABC transporter signature motif; other site 749927025856 Walker B; other site 749927025857 D-loop; other site 749927025858 H-loop/switch region; other site 749927025859 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 749927025860 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 749927025861 NAD(P) binding site [chemical binding]; other site 749927025862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927025863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927025864 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 749927025865 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 749927025866 additional DNA contacts [nucleotide binding]; other site 749927025867 active site 749927025868 zinc binding site [ion binding]; other site 749927025869 DNA intercalation site [nucleotide binding]; other site 749927025870 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 749927025871 cofactor binding site; other site 749927025872 DNA binding site [nucleotide binding] 749927025873 substrate interaction site [chemical binding]; other site 749927025874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 749927025875 ATP binding site [chemical binding]; other site 749927025876 putative Mg++ binding site [ion binding]; other site 749927025877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 749927025878 nucleotide binding region [chemical binding]; other site 749927025879 ATP-binding site [chemical binding]; other site 749927025880 SCP-2 sterol transfer family; Region: SCP2; cl01225 749927025881 SCP-2 sterol transfer family; Region: SCP2; pfam02036 749927025882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927025883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927025884 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 749927025885 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 749927025886 active site 2 [active] 749927025887 active site 1 [active] 749927025888 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 749927025889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927025890 NAD(P) binding site [chemical binding]; other site 749927025891 active site 749927025892 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 749927025893 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 749927025894 dimer interface [polypeptide binding]; other site 749927025895 active site 749927025896 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 749927025897 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 749927025898 DNA binding residues [nucleotide binding] 749927025899 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 749927025900 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 749927025901 AAA ATPase domain; Region: AAA_16; pfam13191 749927025902 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927025903 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 749927025904 putative Zn2+ binding site [ion binding]; other site 749927025905 putative DNA binding site [nucleotide binding]; other site 749927025906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927025907 Coenzyme A binding pocket [chemical binding]; other site 749927025908 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 749927025909 Uncharacterized conserved protein [Function unknown]; Region: COG2128 749927025910 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 749927025911 Na binding site [ion binding]; other site 749927025912 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 749927025913 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 749927025914 TAP-like protein; Region: Abhydrolase_4; pfam08386 749927025915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 749927025916 non-specific DNA binding site [nucleotide binding]; other site 749927025917 salt bridge; other site 749927025918 sequence-specific DNA binding site [nucleotide binding]; other site 749927025919 Predicted acetyltransferase [General function prediction only]; Region: COG3393 749927025920 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 749927025921 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 749927025922 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 749927025923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927025924 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 749927025925 Walker A/P-loop; other site 749927025926 ATP binding site [chemical binding]; other site 749927025927 Q-loop/lid; other site 749927025928 ABC transporter signature motif; other site 749927025929 Walker B; other site 749927025930 D-loop; other site 749927025931 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927025932 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 749927025933 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 749927025934 active site 749927025935 substrate-binding site [chemical binding]; other site 749927025936 metal-binding site [ion binding] 749927025937 GTP binding site [chemical binding]; other site 749927025938 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749927025939 G1 box; other site 749927025940 GTP/Mg2+ binding site [chemical binding]; other site 749927025941 G2 box; other site 749927025942 Switch I region; other site 749927025943 G3 box; other site 749927025944 Switch II region; other site 749927025945 G4 box; other site 749927025946 G5 box; other site 749927025947 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 749927025948 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 749927025949 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749927025950 G1 box; other site 749927025951 GTP/Mg2+ binding site [chemical binding]; other site 749927025952 G2 box; other site 749927025953 Switch I region; other site 749927025954 G3 box; other site 749927025955 Switch II region; other site 749927025956 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927025957 Histidine kinase; Region: HisKA_3; pfam07730 749927025958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927025959 ATP binding site [chemical binding]; other site 749927025960 Mg2+ binding site [ion binding]; other site 749927025961 G-X-G motif; other site 749927025962 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927025963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927025964 active site 749927025965 phosphorylation site [posttranslational modification] 749927025966 intermolecular recognition site; other site 749927025967 dimerization interface [polypeptide binding]; other site 749927025968 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927025969 DNA binding residues [nucleotide binding] 749927025970 dimerization interface [polypeptide binding]; other site 749927025971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927025972 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 749927025973 NAD(P) binding site [chemical binding]; other site 749927025974 active site 749927025975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927025976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927025977 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927025978 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 749927025979 Walker A/P-loop; other site 749927025980 ATP binding site [chemical binding]; other site 749927025981 Q-loop/lid; other site 749927025982 ABC transporter signature motif; other site 749927025983 Walker B; other site 749927025984 D-loop; other site 749927025985 H-loop/switch region; other site 749927025986 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927025987 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 749927025988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 749927025989 Walker A/P-loop; other site 749927025990 ATP binding site [chemical binding]; other site 749927025991 Q-loop/lid; other site 749927025992 ABC transporter signature motif; other site 749927025993 Walker B; other site 749927025994 D-loop; other site 749927025995 H-loop/switch region; other site 749927025996 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 749927025997 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 749927025998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927025999 S-adenosylmethionine binding site [chemical binding]; other site 749927026000 FtsX-like permease family; Region: FtsX; pfam02687 749927026001 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 749927026002 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 749927026003 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 749927026004 Walker A/P-loop; other site 749927026005 ATP binding site [chemical binding]; other site 749927026006 Q-loop/lid; other site 749927026007 ABC transporter signature motif; other site 749927026008 Walker B; other site 749927026009 D-loop; other site 749927026010 H-loop/switch region; other site 749927026011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927026012 Histidine kinase; Region: HisKA_3; pfam07730 749927026013 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 749927026014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927026015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927026016 active site 749927026017 phosphorylation site [posttranslational modification] 749927026018 intermolecular recognition site; other site 749927026019 dimerization interface [polypeptide binding]; other site 749927026020 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927026021 DNA binding residues [nucleotide binding] 749927026022 dimerization interface [polypeptide binding]; other site 749927026023 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 749927026024 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 749927026025 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 749927026026 active site 749927026027 putative substrate binding pocket [chemical binding]; other site 749927026028 short chain dehydrogenase; Provisional; Region: PRK08219 749927026029 classical (c) SDRs; Region: SDR_c; cd05233 749927026030 NAD(P) binding site [chemical binding]; other site 749927026031 active site 749927026032 Domain of unknown function DUF11; Region: DUF11; pfam01345 749927026033 Cna protein B-type domain; Region: Cna_B; pfam05738 749927026034 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 749927026035 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 749927026036 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 749927026037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927026038 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927026039 putative substrate translocation pore; other site 749927026040 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927026041 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927026042 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 749927026043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 749927026044 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 749927026045 active site 749927026046 motif I; other site 749927026047 motif II; other site 749927026048 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 749927026049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927026050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927026051 DNA binding residues [nucleotide binding] 749927026052 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 749927026053 Predicted transcriptional regulators [Transcription]; Region: COG1695 749927026054 Transmembrane domain of transglycosylase PBP1 at N-terminal; Region: PBP1_TM; pfam14812 749927026055 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 749927026056 Transglycosylase; Region: Transgly; pfam00912 749927026057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 749927026058 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 749927026059 Transglycosylase; Region: Transgly; pfam00912 749927026060 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 749927026061 putative oxidoreductase; Provisional; Region: PRK11579 749927026062 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 749927026063 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 749927026064 dimerization interface [polypeptide binding]; other site 749927026065 putative DNA binding site [nucleotide binding]; other site 749927026066 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 749927026067 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927026068 putative Zn2+ binding site [ion binding]; other site 749927026069 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 749927026070 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 749927026071 Predicted integral membrane protein [Function unknown]; Region: COG5650 749927026072 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 749927026073 endonuclease IV; Provisional; Region: PRK01060 749927026074 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 749927026075 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 749927026076 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 749927026077 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 749927026078 dimer interface [polypeptide binding]; other site 749927026079 ssDNA binding site [nucleotide binding]; other site 749927026080 tetramer (dimer of dimers) interface [polypeptide binding]; other site 749927026081 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 749927026082 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 749927026083 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 749927026084 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 749927026085 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 749927026086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927026087 EspG family; Region: ESX-1_EspG; pfam14011 749927026088 replicative DNA helicase; Region: DnaB; TIGR00665 749927026089 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 749927026090 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 749927026091 Walker A motif; other site 749927026092 ATP binding site [chemical binding]; other site 749927026093 Walker B motif; other site 749927026094 DNA binding loops [nucleotide binding] 749927026095 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927026096 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 749927026097 Transcriptional regulators [Transcription]; Region: MarR; COG1846 749927026098 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 749927026099 putative active site [active] 749927026100 metal binding site [ion binding]; metal-binding site 749927026101 large tegument protein UL36; Provisional; Region: PHA03247 749927026102 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 749927026103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927026104 Histidine kinase; Region: HisKA_3; pfam07730 749927026105 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927026106 ATP binding site [chemical binding]; other site 749927026107 Mg2+ binding site [ion binding]; other site 749927026108 G-X-G motif; other site 749927026109 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 749927026110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 749927026111 active site 749927026112 phosphorylation site [posttranslational modification] 749927026113 intermolecular recognition site; other site 749927026114 dimerization interface [polypeptide binding]; other site 749927026115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 749927026116 DNA binding residues [nucleotide binding] 749927026117 dimerization interface [polypeptide binding]; other site 749927026118 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 749927026119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 749927026120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 749927026121 putative substrate translocation pore; other site 749927026122 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 749927026123 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 749927026124 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 749927026125 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 749927026126 ParB-like nuclease domain; Region: ParBc; cl02129 749927026127 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 749927026128 substrate binding site [chemical binding]; other site 749927026129 dimer interface [polypeptide binding]; other site 749927026130 ATP binding site [chemical binding]; other site 749927026131 EspG family; Region: ESX-1_EspG; pfam14011 749927026132 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 749927026133 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 749927026134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 749927026135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 749927026136 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 749927026137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 749927026138 NAD(P) binding site [chemical binding]; other site 749927026139 active site 749927026140 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 749927026141 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 749927026142 active site 749927026143 HIGH motif; other site 749927026144 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 749927026145 KMSKS motif; other site 749927026146 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 749927026147 tRNA binding surface [nucleotide binding]; other site 749927026148 SdiA-regulated; Region: SdiA-regulated; cl19046 749927026149 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 749927026150 SdpI/YhfL protein family; Region: SdpI; pfam13630 749927026151 hypothetical protein; Validated; Region: PRK00228 749927026152 H+ Antiporter protein; Region: 2A0121; TIGR00900 749927026153 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 749927026154 NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129 749927026155 Papain fold toxin 1; Region: Tox-PL; pfam15644 749927026156 NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129 749927026157 Papain fold toxin 1; Region: Tox-PL; pfam15644 749927026158 Region found in RelA / SpoT proteins; Region: RelA_SpoT; smart00954 749927026159 metal binding triad [ion binding]; metal-binding site 749927026160 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 749927026161 Immunity protein 19; Region: Imm19; pfam15567 749927026162 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 749927026163 Immunity protein 19; Region: Imm19; pfam15567 749927026164 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 749927026165 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 749927026166 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 749927026167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 749927026168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 749927026169 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 749927026170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 749927026171 ATP binding site [chemical binding]; other site 749927026172 Mg2+ binding site [ion binding]; other site 749927026173 G-X-G motif; other site 749927026174 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 749927026175 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 749927026176 active site 749927026177 NTP binding site [chemical binding]; other site 749927026178 metal binding triad [ion binding]; metal-binding site 749927026179 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 749927026180 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 749927026181 Zn2+ binding site [ion binding]; other site 749927026182 Mg2+ binding site [ion binding]; other site 749927026183 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 749927026184 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 749927026185 active site 749927026186 Ap6A binding site [chemical binding]; other site 749927026187 nudix motif; other site 749927026188 metal binding site [ion binding]; metal-binding site 749927026189 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 749927026190 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 749927026191 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 749927026192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 749927026193 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 749927026194 DNA binding residues [nucleotide binding] 749927026195 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 749927026196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 749927026197 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 749927026198 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 749927026199 catalytic residues [active] 749927026200 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 749927026201 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927026202 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 749927026203 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 749927026204 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 749927026205 active site 749927026206 metal binding site [ion binding]; metal-binding site 749927026207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 749927026208 Coenzyme A binding pocket [chemical binding]; other site 749927026209 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 749927026210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 749927026211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 749927026212 homodimer interface [polypeptide binding]; other site 749927026213 catalytic residue [active] 749927026214 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 749927026215 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 749927026216 ATP-grasp domain; Region: ATP-grasp_4; cl17255 749927026217 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 749927026218 ParB-like nuclease domain; Region: ParBc; pfam02195 749927026219 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 749927026220 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 749927026221 P-loop; other site 749927026222 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 749927026223 Magnesium ion binding site [ion binding]; other site 749927026224 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 749927026225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 749927026226 S-adenosylmethionine binding site [chemical binding]; other site 749927026227 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 749927026228 G-X-X-G motif; other site 749927026229 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 749927026230 RxxxH motif; other site 749927026231 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 749927026232 Haemolytic domain; Region: Haemolytic; pfam01809 749927026233 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399