-- dump date 20140618_203229 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1156913000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1156913000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913000003 Walker A motif; other site 1156913000004 ATP binding site [chemical binding]; other site 1156913000005 Walker B motif; other site 1156913000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1156913000007 DnaA box-binding interface [nucleotide binding]; other site 1156913000008 DNA polymerase III subunit beta; Validated; Region: PRK07761 1156913000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1156913000010 putative DNA binding surface [nucleotide binding]; other site 1156913000011 dimer interface [polypeptide binding]; other site 1156913000012 beta-clamp/clamp loader binding surface; other site 1156913000013 beta-clamp/translesion DNA polymerase binding surface; other site 1156913000014 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1156913000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1156913000016 recombination protein F; Reviewed; Region: recF; PRK00064 1156913000017 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1156913000018 Walker A/P-loop; other site 1156913000019 ATP binding site [chemical binding]; other site 1156913000020 Q-loop/lid; other site 1156913000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913000022 ABC transporter signature motif; other site 1156913000023 Walker B; other site 1156913000024 D-loop; other site 1156913000025 H-loop/switch region; other site 1156913000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 1156913000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1156913000028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1156913000029 anchoring element; other site 1156913000030 dimer interface [polypeptide binding]; other site 1156913000031 ATP binding site [chemical binding]; other site 1156913000032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1156913000033 active site 1156913000034 putative metal-binding site [ion binding]; other site 1156913000035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1156913000036 DNA gyrase subunit A; Validated; Region: PRK05560 1156913000037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1156913000038 CAP-like domain; other site 1156913000039 active site 1156913000040 primary dimer interface [polypeptide binding]; other site 1156913000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1156913000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1156913000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1156913000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1156913000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1156913000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1156913000047 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1156913000048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913000049 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913000050 putative substrate translocation pore; other site 1156913000051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913000052 PGAP1-like protein; Region: PGAP1; pfam07819 1156913000053 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913000054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913000055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913000056 active site 1156913000057 phosphorylation site [posttranslational modification] 1156913000058 intermolecular recognition site; other site 1156913000059 dimerization interface [polypeptide binding]; other site 1156913000060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913000061 DNA binding residues [nucleotide binding] 1156913000062 dimerization interface [polypeptide binding]; other site 1156913000063 Histidine kinase; Region: HisKA_3; pfam07730 1156913000064 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913000065 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1156913000066 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913000067 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 1156913000068 putative active site [active] 1156913000069 Zn binding site [ion binding]; other site 1156913000070 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1156913000071 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1156913000072 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1156913000073 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 1156913000074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913000075 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913000076 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1156913000077 active site 1156913000078 Rhomboid family; Region: Rhomboid; pfam01694 1156913000079 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1156913000080 putative septation inhibitor protein; Reviewed; Region: PRK00159 1156913000081 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1156913000082 active site 1156913000083 catalytic site [active] 1156913000084 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1156913000085 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913000086 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1156913000087 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913000088 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1156913000089 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913000090 Walker A/P-loop; other site 1156913000091 ATP binding site [chemical binding]; other site 1156913000092 Q-loop/lid; other site 1156913000093 ABC transporter signature motif; other site 1156913000094 Walker B; other site 1156913000095 D-loop; other site 1156913000096 H-loop/switch region; other site 1156913000097 Putative sensor; Region: Sensor; pfam13796 1156913000098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913000099 Histidine kinase; Region: HisKA_3; pfam07730 1156913000100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913000101 Mg2+ binding site [ion binding]; other site 1156913000102 G-X-G motif; other site 1156913000103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913000104 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913000105 active site 1156913000106 phosphorylation site [posttranslational modification] 1156913000107 intermolecular recognition site; other site 1156913000108 dimerization interface [polypeptide binding]; other site 1156913000109 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913000110 DNA binding residues [nucleotide binding] 1156913000111 dimerization interface [polypeptide binding]; other site 1156913000112 ferredoxin-NADP+ reductase; Region: PLN02852 1156913000113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913000114 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1156913000115 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1156913000116 glutamine binding [chemical binding]; other site 1156913000117 catalytic triad [active] 1156913000118 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1156913000119 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913000120 Walker A/P-loop; other site 1156913000121 ATP binding site [chemical binding]; other site 1156913000122 Q-loop/lid; other site 1156913000123 ABC transporter signature motif; other site 1156913000124 Walker B; other site 1156913000125 D-loop; other site 1156913000126 H-loop/switch region; other site 1156913000127 AAA domain; Region: AAA_14; pfam13173 1156913000128 AAA domain; Region: AAA_33; pfam13671 1156913000129 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1156913000130 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913000131 active site 1156913000132 ATP binding site [chemical binding]; other site 1156913000133 substrate binding site [chemical binding]; other site 1156913000134 activation loop (A-loop); other site 1156913000135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1156913000136 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1156913000137 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1156913000138 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1156913000139 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1156913000140 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913000141 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913000142 active site 1156913000143 ATP binding site [chemical binding]; other site 1156913000144 substrate binding site [chemical binding]; other site 1156913000145 activation loop (A-loop); other site 1156913000146 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1156913000147 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1156913000148 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1156913000149 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1156913000150 active site 1156913000151 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1156913000152 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1156913000153 phosphopeptide binding site; other site 1156913000154 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1156913000155 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1156913000156 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1156913000157 phosphopeptide binding site; other site 1156913000158 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1156913000159 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1156913000160 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1156913000161 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1156913000162 active site 1156913000163 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913000164 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1156913000165 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913000166 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913000167 catalytic residue [active] 1156913000168 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1156913000169 active site 1156913000170 putative catalytic site [active] 1156913000171 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1156913000172 active site 1156913000173 nucleophile elbow; other site 1156913000174 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1156913000175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913000176 DNA-binding site [nucleotide binding]; DNA binding site 1156913000177 FCD domain; Region: FCD; pfam07729 1156913000178 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1156913000179 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1156913000180 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1156913000181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913000182 dimer interface [polypeptide binding]; other site 1156913000183 conserved gate region; other site 1156913000184 putative PBP binding loops; other site 1156913000185 ABC-ATPase subunit interface; other site 1156913000186 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1156913000187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913000188 dimer interface [polypeptide binding]; other site 1156913000189 conserved gate region; other site 1156913000190 putative PBP binding loops; other site 1156913000191 ABC-ATPase subunit interface; other site 1156913000192 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1156913000193 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913000194 Walker A/P-loop; other site 1156913000195 ATP binding site [chemical binding]; other site 1156913000196 Q-loop/lid; other site 1156913000197 ABC transporter signature motif; other site 1156913000198 Walker B; other site 1156913000199 D-loop; other site 1156913000200 H-loop/switch region; other site 1156913000201 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1156913000202 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1156913000203 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913000204 Walker A/P-loop; other site 1156913000205 ATP binding site [chemical binding]; other site 1156913000206 Q-loop/lid; other site 1156913000207 ABC transporter signature motif; other site 1156913000208 Walker B; other site 1156913000209 D-loop; other site 1156913000210 H-loop/switch region; other site 1156913000211 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1156913000212 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913000213 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913000214 NAD(P) binding site [chemical binding]; other site 1156913000215 catalytic residues [active] 1156913000216 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913000217 classical (c) SDRs; Region: SDR_c; cd05233 1156913000218 NAD(P) binding site [chemical binding]; other site 1156913000219 active site 1156913000220 amidase; Provisional; Region: PRK07042 1156913000221 Amidase; Region: Amidase; cl11426 1156913000222 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1156913000223 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1156913000224 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913000225 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913000226 active site 1156913000227 ATP binding site [chemical binding]; other site 1156913000228 substrate binding site [chemical binding]; other site 1156913000229 activation loop (A-loop); other site 1156913000230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913000231 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913000232 active site 1156913000233 ATP binding site [chemical binding]; other site 1156913000234 substrate binding site [chemical binding]; other site 1156913000235 activation loop (A-loop); other site 1156913000236 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1156913000237 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1156913000238 NAD(P) binding site [chemical binding]; other site 1156913000239 putative active site [active] 1156913000240 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1156913000241 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1156913000242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1156913000243 active site 1156913000244 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1156913000245 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913000246 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1156913000247 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1156913000248 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1156913000249 dimer interface [polypeptide binding]; other site 1156913000250 active site 1156913000251 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1156913000252 substrate binding site [chemical binding]; other site 1156913000253 catalytic residue [active] 1156913000254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913000255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913000256 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1156913000257 beta-galactosidase; Region: BGL; TIGR03356 1156913000258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913000259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913000260 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913000261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913000262 salt bridge; other site 1156913000263 non-specific DNA binding site [nucleotide binding]; other site 1156913000264 sequence-specific DNA binding site [nucleotide binding]; other site 1156913000265 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913000266 Phosphotransferase enzyme family; Region: APH; pfam01636 1156913000267 active site 1156913000268 ATP binding site [chemical binding]; other site 1156913000269 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1156913000270 NB-ARC domain; Region: NB-ARC; pfam00931 1156913000271 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913000272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1156913000273 TPR motif; other site 1156913000274 binding surface 1156913000275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913000276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913000277 binding surface 1156913000278 TPR motif; other site 1156913000279 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913000280 Copper resistance protein D; Region: CopD; pfam05425 1156913000281 CopC domain; Region: CopC; pfam04234 1156913000282 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1156913000283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913000284 dimer interface [polypeptide binding]; other site 1156913000285 conserved gate region; other site 1156913000286 putative PBP binding loops; other site 1156913000287 ABC-ATPase subunit interface; other site 1156913000288 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1156913000289 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1156913000290 Walker A/P-loop; other site 1156913000291 ATP binding site [chemical binding]; other site 1156913000292 Q-loop/lid; other site 1156913000293 ABC transporter signature motif; other site 1156913000294 Walker B; other site 1156913000295 D-loop; other site 1156913000296 H-loop/switch region; other site 1156913000297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913000298 dimer interface [polypeptide binding]; other site 1156913000299 conserved gate region; other site 1156913000300 putative PBP binding loops; other site 1156913000301 ABC-ATPase subunit interface; other site 1156913000302 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1156913000303 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1156913000304 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1156913000305 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913000306 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1156913000307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913000308 S-adenosylmethionine binding site [chemical binding]; other site 1156913000309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913000310 NAD(P) binding site [chemical binding]; other site 1156913000311 active site 1156913000312 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1156913000313 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1156913000314 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1156913000315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913000316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913000317 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1156913000318 hypothetical protein; Provisional; Region: PRK07236 1156913000319 hypothetical protein; Provisional; Region: PRK07588 1156913000320 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1156913000321 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1156913000322 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1156913000323 putative dimer interface [polypeptide binding]; other site 1156913000324 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913000325 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1156913000326 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913000327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913000328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913000329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913000330 putative substrate translocation pore; other site 1156913000331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913000332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913000333 salt bridge; other site 1156913000334 non-specific DNA binding site [nucleotide binding]; other site 1156913000335 sequence-specific DNA binding site [nucleotide binding]; other site 1156913000336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1156913000337 Histidine kinase; Region: HisKA_3; pfam07730 1156913000338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913000339 ATP binding site [chemical binding]; other site 1156913000340 Mg2+ binding site [ion binding]; other site 1156913000341 G-X-G motif; other site 1156913000342 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913000343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913000344 active site 1156913000345 phosphorylation site [posttranslational modification] 1156913000346 intermolecular recognition site; other site 1156913000347 dimerization interface [polypeptide binding]; other site 1156913000348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913000349 DNA binding residues [nucleotide binding] 1156913000350 dimerization interface [polypeptide binding]; other site 1156913000351 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1156913000352 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1156913000353 ligand binding site [chemical binding]; other site 1156913000354 flexible hinge region; other site 1156913000355 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1156913000356 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1156913000357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1156913000358 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1156913000359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913000360 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1156913000361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1156913000362 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1156913000363 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 1156913000364 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913000365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913000366 non-specific DNA binding site [nucleotide binding]; other site 1156913000367 salt bridge; other site 1156913000368 sequence-specific DNA binding site [nucleotide binding]; other site 1156913000369 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1156913000370 yiaA/B two helix domain; Region: YiaAB; cl01759 1156913000371 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1156913000372 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1156913000373 Putative zinc-finger; Region: zf-HC2; pfam13490 1156913000374 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1156913000375 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1156913000376 putative DNA binding site [nucleotide binding]; other site 1156913000377 catalytic residue [active] 1156913000378 putative H2TH interface [polypeptide binding]; other site 1156913000379 putative catalytic residues [active] 1156913000380 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1156913000381 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1156913000382 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913000383 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913000384 Histidine kinase; Region: His_kinase; pfam06580 1156913000385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913000386 ATP binding site [chemical binding]; other site 1156913000387 Mg2+ binding site [ion binding]; other site 1156913000388 G-X-G motif; other site 1156913000389 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1156913000390 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1156913000391 tandem repeat interface [polypeptide binding]; other site 1156913000392 oligomer interface [polypeptide binding]; other site 1156913000393 active site residues [active] 1156913000394 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 1156913000395 active site 1156913000396 catalytic residues [active] 1156913000397 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1156913000398 metal binding site [ion binding]; metal-binding site 1156913000399 ligand binding site [chemical binding]; other site 1156913000400 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1156913000401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913000402 active site 1156913000403 phosphorylation site [posttranslational modification] 1156913000404 intermolecular recognition site; other site 1156913000405 dimerization interface [polypeptide binding]; other site 1156913000406 LytTr DNA-binding domain; Region: LytTR; smart00850 1156913000407 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1156913000408 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1156913000409 Na binding site [ion binding]; other site 1156913000410 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1156913000411 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1156913000412 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1156913000413 Na binding site [ion binding]; other site 1156913000414 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1156913000415 active site residue [active] 1156913000416 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1156913000417 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1156913000418 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913000419 Cytochrome P450; Region: p450; cl12078 1156913000420 Protein of unknown function (DUF952); Region: DUF952; pfam06108 1156913000421 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1156913000422 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913000423 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913000424 DNA binding residues [nucleotide binding] 1156913000425 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1156913000426 Ferritin-like domain; Region: Ferritin; pfam00210 1156913000427 ferroxidase diiron center [ion binding]; other site 1156913000428 arginine deiminase; Provisional; Region: PRK01388 1156913000429 CAAX protease self-immunity; Region: Abi; pfam02517 1156913000430 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1156913000431 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1156913000432 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1156913000433 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1156913000434 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1156913000435 metal ion-dependent adhesion site (MIDAS); other site 1156913000436 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1156913000437 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1156913000438 Predicted membrane protein [Function unknown]; Region: COG2119 1156913000439 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1156913000440 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1156913000441 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 1156913000442 active site triad [active] 1156913000443 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1156913000444 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1156913000445 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1156913000446 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1156913000447 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1156913000448 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 1156913000449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913000450 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1156913000451 Walker A/P-loop; other site 1156913000452 ATP binding site [chemical binding]; other site 1156913000453 Q-loop/lid; other site 1156913000454 ABC transporter signature motif; other site 1156913000455 Walker B; other site 1156913000456 D-loop; other site 1156913000457 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1156913000458 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913000459 Walker A/P-loop; other site 1156913000460 ATP binding site [chemical binding]; other site 1156913000461 Q-loop/lid; other site 1156913000462 ABC transporter signature motif; other site 1156913000463 Walker B; other site 1156913000464 D-loop; other site 1156913000465 H-loop/switch region; other site 1156913000466 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1156913000467 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1156913000468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913000469 Histidine kinase; Region: HisKA_3; pfam07730 1156913000470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913000471 ATP binding site [chemical binding]; other site 1156913000472 Mg2+ binding site [ion binding]; other site 1156913000473 G-X-G motif; other site 1156913000474 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1156913000475 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1156913000476 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1156913000477 active site 1156913000478 putative catalytic site [active] 1156913000479 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913000480 catalytic core [active] 1156913000481 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1156913000482 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913000483 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913000484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913000485 active site 1156913000486 phosphorylation site [posttranslational modification] 1156913000487 intermolecular recognition site; other site 1156913000488 dimerization interface [polypeptide binding]; other site 1156913000489 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913000490 DNA binding residues [nucleotide binding] 1156913000491 dimerization interface [polypeptide binding]; other site 1156913000492 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1156913000493 active site 1156913000494 Zn binding site [ion binding]; other site 1156913000495 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1156913000496 homodimer interface [polypeptide binding]; other site 1156913000497 chemical substrate binding site [chemical binding]; other site 1156913000498 oligomer interface [polypeptide binding]; other site 1156913000499 metal binding site [ion binding]; metal-binding site 1156913000500 Nitrate and nitrite sensing; Region: NIT; pfam08376 1156913000501 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1156913000502 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1156913000503 pantothenate kinase; Provisional; Region: PRK05439 1156913000504 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1156913000505 ATP-binding site [chemical binding]; other site 1156913000506 CoA-binding site [chemical binding]; other site 1156913000507 Mg2+-binding site [ion binding]; other site 1156913000508 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1156913000509 ADP-ribose binding site [chemical binding]; other site 1156913000510 prephenate dehydratase; Provisional; Region: PRK11898 1156913000511 Prephenate dehydratase; Region: PDT; pfam00800 1156913000512 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1156913000513 putative L-Phe binding site [chemical binding]; other site 1156913000514 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913000515 catalytic core [active] 1156913000516 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1156913000517 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913000518 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1156913000519 Septum formation; Region: Septum_form; pfam13845 1156913000520 Septum formation; Region: Septum_form; pfam13845 1156913000521 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1156913000522 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1156913000523 haloalkane dehalogenase; Provisional; Region: PRK00870 1156913000524 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1156913000525 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913000526 inhibitor-cofactor binding pocket; inhibition site 1156913000527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913000528 catalytic residue [active] 1156913000529 seryl-tRNA synthetase; Provisional; Region: PRK05431 1156913000530 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1156913000531 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1156913000532 dimer interface [polypeptide binding]; other site 1156913000533 active site 1156913000534 motif 1; other site 1156913000535 motif 2; other site 1156913000536 motif 3; other site 1156913000537 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1156913000538 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1156913000539 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1156913000540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913000541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913000542 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913000543 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1156913000544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913000545 putative substrate translocation pore; other site 1156913000546 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1156913000547 active site 1156913000548 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1156913000549 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913000550 DNA binding site [nucleotide binding] 1156913000551 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913000552 Predicted ATPase [General function prediction only]; Region: COG3903 1156913000553 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913000554 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913000555 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1156913000556 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1156913000557 inhibitor-cofactor binding pocket; inhibition site 1156913000558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913000559 catalytic residue [active] 1156913000560 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913000561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913000562 NAD(P) binding site [chemical binding]; other site 1156913000563 active site 1156913000564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913000565 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1156913000566 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1156913000567 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1156913000568 trimer interface [polypeptide binding]; other site 1156913000569 active site 1156913000570 substrate binding site [chemical binding]; other site 1156913000571 CoA binding site [chemical binding]; other site 1156913000572 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1156913000573 putative active site [active] 1156913000574 CopC domain; Region: CopC; pfam04234 1156913000575 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1156913000576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913000577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913000578 DNA binding residues [nucleotide binding] 1156913000579 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1156913000580 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913000581 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1156913000582 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1156913000583 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1156913000584 inhibitor-cofactor binding pocket; inhibition site 1156913000585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913000586 catalytic residue [active] 1156913000587 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1156913000588 putative trimer interface [polypeptide binding]; other site 1156913000589 putative CoA binding site [chemical binding]; other site 1156913000590 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1156913000591 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913000592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913000593 NAD(P) binding site [chemical binding]; other site 1156913000594 active site 1156913000595 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1156913000596 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913000597 acyl-activating enzyme (AAE) consensus motif; other site 1156913000598 AMP binding site [chemical binding]; other site 1156913000599 active site 1156913000600 CoA binding site [chemical binding]; other site 1156913000601 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1156913000602 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913000603 NAD(P) binding site [chemical binding]; other site 1156913000604 catalytic residues [active] 1156913000605 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1156913000606 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1156913000607 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1156913000608 putative acyl-acceptor binding pocket; other site 1156913000609 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1156913000610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913000611 active site 1156913000612 motif I; other site 1156913000613 motif II; other site 1156913000614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913000615 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1156913000616 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913000617 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1156913000618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913000619 UDP-galactopyranose mutase; Region: GLF; pfam03275 1156913000620 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1156913000621 active site 1156913000622 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1156913000623 short chain dehydrogenase; Provisional; Region: PRK07904 1156913000624 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1156913000625 NAD(P) binding site [chemical binding]; other site 1156913000626 active site 1156913000627 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1156913000628 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913000629 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1156913000630 Predicted membrane protein [Function unknown]; Region: COG2246 1156913000631 GtrA-like protein; Region: GtrA; pfam04138 1156913000632 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1156913000633 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913000634 active site 1156913000635 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913000636 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913000637 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1156913000638 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913000639 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1156913000640 EspG family; Region: ESX-1_EspG; pfam14011 1156913000641 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1156913000642 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913000643 active site 1156913000644 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1156913000645 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1156913000646 Walker A/P-loop; other site 1156913000647 ATP binding site [chemical binding]; other site 1156913000648 Q-loop/lid; other site 1156913000649 ABC transporter signature motif; other site 1156913000650 Walker B; other site 1156913000651 D-loop; other site 1156913000652 H-loop/switch region; other site 1156913000653 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1156913000654 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1156913000655 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1156913000656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1156913000657 pseudaminic acid synthase; Region: PseI; TIGR03586 1156913000658 NeuB family; Region: NeuB; pfam03102 1156913000659 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1156913000660 NeuB binding interface [polypeptide binding]; other site 1156913000661 putative substrate binding site [chemical binding]; other site 1156913000662 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1156913000663 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1156913000664 inhibitor-cofactor binding pocket; inhibition site 1156913000665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913000666 catalytic residue [active] 1156913000667 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1156913000668 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1156913000669 NAD(P) binding site [chemical binding]; other site 1156913000670 homodimer interface [polypeptide binding]; other site 1156913000671 substrate binding site [chemical binding]; other site 1156913000672 active site 1156913000673 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913000674 active site 1156913000675 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1156913000676 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913000677 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1156913000678 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913000679 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1156913000680 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1156913000681 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913000682 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913000683 catalytic residue [active] 1156913000684 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1156913000685 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1156913000686 NAD(P) binding site [chemical binding]; other site 1156913000687 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1156913000688 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1156913000689 PA/protease or protease-like domain interface [polypeptide binding]; other site 1156913000690 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1156913000691 Peptidase family M28; Region: Peptidase_M28; pfam04389 1156913000692 active site 1156913000693 metal binding site [ion binding]; metal-binding site 1156913000694 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1156913000695 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913000696 MarR family; Region: MarR_2; pfam12802 1156913000697 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1156913000698 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913000699 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1156913000700 YCII-related domain; Region: YCII; cl00999 1156913000701 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1156913000702 Ricin-type beta-trefoil; Region: RICIN; smart00458 1156913000703 putative sugar binding sites [chemical binding]; other site 1156913000704 Q-X-W motif; other site 1156913000705 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1156913000706 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1156913000707 putative sugar binding sites [chemical binding]; other site 1156913000708 Q-X-W motif; other site 1156913000709 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1156913000710 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1156913000711 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1156913000712 S4 domain; Region: S4_2; pfam13275 1156913000713 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913000714 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1156913000715 classical (c) SDRs; Region: SDR_c; cd05233 1156913000716 NAD(P) binding site [chemical binding]; other site 1156913000717 active site 1156913000718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913000719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913000720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913000721 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1156913000722 conserved cys residue [active] 1156913000723 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913000724 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913000725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913000726 metal binding site [ion binding]; metal-binding site 1156913000727 active site 1156913000728 I-site; other site 1156913000729 RHS Repeat; Region: RHS_repeat; cl11982 1156913000730 RHS Repeat; Region: RHS_repeat; pfam05593 1156913000731 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1156913000732 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1156913000733 RHS Repeat; Region: RHS_repeat; pfam05593 1156913000734 RHS Repeat; Region: RHS_repeat; pfam05593 1156913000735 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1156913000736 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1156913000737 RHS Repeat; Region: RHS_repeat; pfam05593 1156913000738 RHS Repeat; Region: RHS_repeat; pfam05593 1156913000739 RHS Repeat; Region: RHS_repeat; cl11982 1156913000740 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1156913000741 Agrobacterium VirD5 protein; Region: Agro_virD5; cl10634 1156913000742 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1156913000743 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1156913000744 EspG family; Region: ESX-1_EspG; pfam14011 1156913000745 AAA ATPase domain; Region: AAA_16; pfam13191 1156913000746 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913000747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913000748 DNA binding residues [nucleotide binding] 1156913000749 dimerization interface [polypeptide binding]; other site 1156913000750 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1156913000751 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913000752 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 1156913000753 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913000754 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913000755 putative DNA binding site [nucleotide binding]; other site 1156913000756 putative Zn2+ binding site [ion binding]; other site 1156913000757 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913000758 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1156913000759 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1156913000760 dimer interface [polypeptide binding]; other site 1156913000761 active site 1156913000762 CoA binding pocket [chemical binding]; other site 1156913000763 HAMP domain; Region: HAMP; pfam00672 1156913000764 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1156913000765 cyclase homology domain; Region: CHD; cd07302 1156913000766 nucleotidyl binding site; other site 1156913000767 metal binding site [ion binding]; metal-binding site 1156913000768 dimer interface [polypeptide binding]; other site 1156913000769 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1156913000770 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1156913000771 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1156913000772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913000773 DNA-binding site [nucleotide binding]; DNA binding site 1156913000774 FCD domain; Region: FCD; pfam07729 1156913000775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1156913000776 hypothetical protein; Provisional; Region: PRK10621 1156913000777 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1156913000778 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1156913000779 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913000780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913000781 homodimer interface [polypeptide binding]; other site 1156913000782 catalytic residue [active] 1156913000783 Dienelactone hydrolase family; Region: DLH; pfam01738 1156913000784 PPE family; Region: PPE; pfam00823 1156913000785 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1156913000786 EspG family; Region: ESX-1_EspG; pfam14011 1156913000787 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1156913000788 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913000789 acyl-activating enzyme (AAE) consensus motif; other site 1156913000790 AMP binding site [chemical binding]; other site 1156913000791 active site 1156913000792 CoA binding site [chemical binding]; other site 1156913000793 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1156913000794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913000795 ATP binding site [chemical binding]; other site 1156913000796 Mg2+ binding site [ion binding]; other site 1156913000797 G-X-G motif; other site 1156913000798 Restriction endonuclease; Region: Mrr_cat; pfam04471 1156913000799 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1156913000800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913000801 ATP binding site [chemical binding]; other site 1156913000802 putative Mg++ binding site [ion binding]; other site 1156913000803 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1156913000804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913000805 nucleotide binding region [chemical binding]; other site 1156913000806 ATP-binding site [chemical binding]; other site 1156913000807 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1156913000808 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1156913000809 cofactor binding site; other site 1156913000810 DNA binding site [nucleotide binding] 1156913000811 substrate interaction site [chemical binding]; other site 1156913000812 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1156913000813 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1156913000814 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913000815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913000816 NAD(P) binding site [chemical binding]; other site 1156913000817 active site 1156913000818 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1156913000819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913000820 TPR motif; other site 1156913000821 binding surface 1156913000822 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1156913000823 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1156913000824 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913000825 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1156913000826 Nitroreductase family; Region: Nitroreductase; pfam00881 1156913000827 FMN binding site [chemical binding]; other site 1156913000828 dimer interface [polypeptide binding]; other site 1156913000829 MarR family; Region: MarR_2; pfam12802 1156913000830 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1156913000831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913000832 Mg2+ binding site [ion binding]; other site 1156913000833 G-X-G motif; other site 1156913000834 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1156913000835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913000836 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1156913000837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913000838 DNA binding residues [nucleotide binding] 1156913000839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1156913000840 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1156913000841 Transcription factor WhiB; Region: Whib; pfam02467 1156913000842 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1156913000843 anti sigma factor interaction site; other site 1156913000844 regulatory phosphorylation site [posttranslational modification]; other site 1156913000845 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1156913000846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913000847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913000848 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1156913000849 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913000850 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913000851 Walker A/P-loop; other site 1156913000852 ATP binding site [chemical binding]; other site 1156913000853 Q-loop/lid; other site 1156913000854 ABC transporter signature motif; other site 1156913000855 Walker B; other site 1156913000856 D-loop; other site 1156913000857 H-loop/switch region; other site 1156913000858 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1156913000859 Predicted transcriptional regulators [Transcription]; Region: COG1510 1156913000860 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913000861 putative DNA binding site [nucleotide binding]; other site 1156913000862 putative Zn2+ binding site [ion binding]; other site 1156913000863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913000864 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1156913000865 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1156913000866 NAD binding site [chemical binding]; other site 1156913000867 substrate binding site [chemical binding]; other site 1156913000868 putative active site [active] 1156913000869 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1156913000870 active site 1156913000871 catalytic triad [active] 1156913000872 oxyanion hole [active] 1156913000873 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913000874 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913000875 CHAT domain; Region: CHAT; cl17868 1156913000876 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1156913000877 hydrophobic ligand binding site; other site 1156913000878 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1156913000879 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1156913000880 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1156913000881 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1156913000882 active site 1156913000883 iron coordination sites [ion binding]; other site 1156913000884 substrate binding pocket [chemical binding]; other site 1156913000885 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1156913000886 prephenate dehydrogenase; Validated; Region: PRK06545 1156913000887 prephenate dehydrogenase; Validated; Region: PRK08507 1156913000888 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1156913000889 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1156913000890 active site 1156913000891 FMN binding site [chemical binding]; other site 1156913000892 2,4-decadienoyl-CoA binding site; other site 1156913000893 catalytic residue [active] 1156913000894 4Fe-4S cluster binding site [ion binding]; other site 1156913000895 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1156913000896 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913000897 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913000898 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1156913000899 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1156913000900 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1156913000901 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1156913000902 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913000903 MarR family; Region: MarR; pfam01047 1156913000904 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1156913000905 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1156913000906 substrate binding pocket [chemical binding]; other site 1156913000907 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913000908 Putative esterase; Region: Esterase; pfam00756 1156913000909 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1156913000910 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1156913000911 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1156913000912 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1156913000913 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1156913000914 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1156913000915 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1156913000916 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1156913000917 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1156913000918 tetramer interface [polypeptide binding]; other site 1156913000919 active site 1156913000920 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1156913000921 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1156913000922 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1156913000923 DNA binding residues [nucleotide binding] 1156913000924 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1156913000925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913000926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913000927 DNA binding residues [nucleotide binding] 1156913000928 dimerization interface [polypeptide binding]; other site 1156913000929 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1156913000930 active site 1156913000931 putative catalytic site [active] 1156913000932 cytosine deaminase; Provisional; Region: PRK05985 1156913000933 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1156913000934 active site 1156913000935 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1156913000936 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1156913000937 RHS Repeat; Region: RHS_repeat; cl11982 1156913000938 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1156913000939 RHS Repeat; Region: RHS_repeat; pfam05593 1156913000940 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1156913000941 xanthine permease; Region: pbuX; TIGR03173 1156913000942 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1156913000943 DNA-binding site [nucleotide binding]; DNA binding site 1156913000944 RNA-binding motif; other site 1156913000945 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913000946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1156913000947 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913000948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1156913000949 active site 1156913000950 phosphorylation site [posttranslational modification] 1156913000951 intermolecular recognition site; other site 1156913000952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913000953 DNA binding residues [nucleotide binding] 1156913000954 dimerization interface [polypeptide binding]; other site 1156913000955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913000956 Histidine kinase; Region: HisKA_3; pfam07730 1156913000957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913000958 ATP binding site [chemical binding]; other site 1156913000959 Mg2+ binding site [ion binding]; other site 1156913000960 G-X-G motif; other site 1156913000961 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913000962 oxidoreductase; Provisional; Region: PRK06196 1156913000963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913000964 NAD(P) binding site [chemical binding]; other site 1156913000965 active site 1156913000966 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1156913000967 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1156913000968 DNA binding residues [nucleotide binding] 1156913000969 putative dimer interface [polypeptide binding]; other site 1156913000970 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913000971 mce related protein; Region: MCE; pfam02470 1156913000972 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1156913000973 active site 1156913000974 ATP binding site [chemical binding]; other site 1156913000975 substrate binding site [chemical binding]; other site 1156913000976 activation loop (A-loop); other site 1156913000977 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1156913000978 active site 1156913000979 zinc binding site [ion binding]; other site 1156913000980 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913000981 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1156913000982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913000983 Walker A/P-loop; other site 1156913000984 ATP binding site [chemical binding]; other site 1156913000985 Q-loop/lid; other site 1156913000986 ABC transporter signature motif; other site 1156913000987 Walker B; other site 1156913000988 D-loop; other site 1156913000989 H-loop/switch region; other site 1156913000990 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913000991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913000992 Walker A/P-loop; other site 1156913000993 ATP binding site [chemical binding]; other site 1156913000994 Q-loop/lid; other site 1156913000995 ABC transporter signature motif; other site 1156913000996 Walker B; other site 1156913000997 D-loop; other site 1156913000998 H-loop/switch region; other site 1156913000999 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1156913001000 active site 1156913001001 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1156913001002 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1156913001003 active site 1156913001004 NAD binding site [chemical binding]; other site 1156913001005 metal binding site [ion binding]; metal-binding site 1156913001006 thiamine pyrophosphate protein; Validated; Region: PRK08199 1156913001007 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1156913001008 PYR/PP interface [polypeptide binding]; other site 1156913001009 dimer interface [polypeptide binding]; other site 1156913001010 TPP binding site [chemical binding]; other site 1156913001011 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1156913001012 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1156913001013 TPP-binding site [chemical binding]; other site 1156913001014 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1156913001015 DNA-binding site [nucleotide binding]; DNA binding site 1156913001016 RNA-binding motif; other site 1156913001017 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1156913001018 GAF domain; Region: GAF; pfam01590 1156913001019 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1156913001020 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913001021 substrate binding pocket [chemical binding]; other site 1156913001022 membrane-bound complex binding site; other site 1156913001023 hinge residues; other site 1156913001024 EspG family; Region: ESX-1_EspG; pfam14011 1156913001025 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913001026 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913001027 active site 1156913001028 ATP binding site [chemical binding]; other site 1156913001029 substrate binding site [chemical binding]; other site 1156913001030 activation loop (A-loop); other site 1156913001031 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1156913001032 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1156913001033 active site 2 [active] 1156913001034 active site 1 [active] 1156913001035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913001036 metabolite-proton symporter; Region: 2A0106; TIGR00883 1156913001037 putative substrate translocation pore; other site 1156913001038 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1156913001039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913001040 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913001041 DNA binding residues [nucleotide binding] 1156913001042 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1156913001043 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1156913001044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1156913001045 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1156913001046 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1156913001047 DNA-binding site [nucleotide binding]; DNA binding site 1156913001048 RNA-binding motif; other site 1156913001049 mannonate dehydratase; Provisional; Region: PRK03906 1156913001050 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1156913001051 cleavage site 1156913001052 active site 1156913001053 substrate binding sites [chemical binding]; other site 1156913001054 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1156913001055 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1156913001056 PAS domain; Region: PAS_9; pfam13426 1156913001057 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1156913001058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1156913001059 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 1156913001060 putative active site [active] 1156913001061 heme pocket [chemical binding]; other site 1156913001062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1156913001063 putative active site [active] 1156913001064 heme pocket [chemical binding]; other site 1156913001065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1156913001066 putative active site [active] 1156913001067 heme pocket [chemical binding]; other site 1156913001068 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913001069 metal binding site [ion binding]; metal-binding site 1156913001070 active site 1156913001071 I-site; other site 1156913001072 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1156913001073 xanthine permease; Region: pbuX; TIGR03173 1156913001074 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1156913001075 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913001076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913001077 Clp protease ATP binding subunit; Region: clpC; CHL00095 1156913001078 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1156913001079 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1156913001080 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1156913001081 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913001082 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913001083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913001084 non-specific DNA binding site [nucleotide binding]; other site 1156913001085 salt bridge; other site 1156913001086 sequence-specific DNA binding site [nucleotide binding]; other site 1156913001087 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1156913001088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1156913001089 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1156913001090 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1156913001091 YtkA-like; Region: YtkA; pfam13115 1156913001092 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1156913001093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1156913001094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913001095 amidase; Provisional; Region: PRK06061 1156913001096 Amidase; Region: Amidase; cl11426 1156913001097 D-cysteine desulfhydrase; Validated; Region: PRK03910 1156913001098 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1156913001099 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913001100 catalytic residue [active] 1156913001101 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1156913001102 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; cl17893 1156913001103 Clp amino terminal domain; Region: Clp_N; pfam02861 1156913001104 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1156913001105 Predicted membrane protein [Function unknown]; Region: COG2364 1156913001106 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1156913001107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913001108 DNA-binding site [nucleotide binding]; DNA binding site 1156913001109 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913001110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913001111 homodimer interface [polypeptide binding]; other site 1156913001112 catalytic residue [active] 1156913001113 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913001114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1156913001115 aminotransferase; Validated; Region: PRK07777 1156913001116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913001117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913001118 homodimer interface [polypeptide binding]; other site 1156913001119 catalytic residue [active] 1156913001120 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1156913001121 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913001122 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913001123 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913001124 active site 1156913001125 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1156913001126 AAA domain; Region: AAA_18; pfam13238 1156913001127 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1156913001128 active site 1156913001129 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 1156913001130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913001131 S-adenosylmethionine binding site [chemical binding]; other site 1156913001132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913001133 non-specific DNA binding site [nucleotide binding]; other site 1156913001134 salt bridge; other site 1156913001135 sequence-specific DNA binding site [nucleotide binding]; other site 1156913001136 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 1156913001137 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1156913001138 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1156913001139 putative deacylase active site [active] 1156913001140 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1156913001141 active sites [active] 1156913001142 tetramer interface [polypeptide binding]; other site 1156913001143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913001144 dimer interface [polypeptide binding]; other site 1156913001145 conserved gate region; other site 1156913001146 putative PBP binding loops; other site 1156913001147 ABC-ATPase subunit interface; other site 1156913001148 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1156913001149 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1156913001150 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1156913001151 hydrophobic ligand binding site; other site 1156913001152 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1156913001153 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1156913001154 NAD(P) binding site [chemical binding]; other site 1156913001155 substrate binding site [chemical binding]; other site 1156913001156 dimer interface [polypeptide binding]; other site 1156913001157 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1156913001158 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1156913001159 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1156913001160 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1156913001161 putative active site [active] 1156913001162 putative substrate binding site [chemical binding]; other site 1156913001163 putative cosubstrate binding site; other site 1156913001164 catalytic site [active] 1156913001165 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1156913001166 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1156913001167 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1156913001168 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1156913001169 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913001170 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1156913001171 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1156913001172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1156913001173 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1156913001174 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1156913001175 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913001176 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913001177 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1156913001178 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1156913001179 putative ADP-binding pocket [chemical binding]; other site 1156913001180 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1156913001181 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1156913001182 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913001183 catalytic core [active] 1156913001184 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913001185 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1156913001186 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913001187 dimer interface [polypeptide binding]; other site 1156913001188 phosphorylation site [posttranslational modification] 1156913001189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913001190 ATP binding site [chemical binding]; other site 1156913001191 Mg2+ binding site [ion binding]; other site 1156913001192 G-X-G motif; other site 1156913001193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913001194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913001195 active site 1156913001196 phosphorylation site [posttranslational modification] 1156913001197 intermolecular recognition site; other site 1156913001198 dimerization interface [polypeptide binding]; other site 1156913001199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913001200 DNA binding site [nucleotide binding] 1156913001201 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1156913001202 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1156913001203 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1156913001204 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1156913001205 DNA interaction; other site 1156913001206 Metal-binding active site; metal-binding site 1156913001207 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1156913001208 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1156913001209 active site 2 [active] 1156913001210 active site 1 [active] 1156913001211 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1156913001212 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1156913001213 DNA binding domain, excisionase family; Region: excise; TIGR01764 1156913001214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913001215 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913001216 NAD(P) binding site [chemical binding]; other site 1156913001217 active site 1156913001218 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1156913001219 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1156913001220 putative acyl-acceptor binding pocket; other site 1156913001221 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1156913001222 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1156913001223 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 1156913001224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913001225 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913001226 DNA binding residues [nucleotide binding] 1156913001227 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1156913001228 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913001229 acyl-activating enzyme (AAE) consensus motif; other site 1156913001230 AMP binding site [chemical binding]; other site 1156913001231 active site 1156913001232 CoA binding site [chemical binding]; other site 1156913001233 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1156913001234 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1156913001235 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1156913001236 Moco binding site; other site 1156913001237 metal coordination site [ion binding]; other site 1156913001238 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1156913001239 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1156913001240 CoA binding domain; Region: CoA_binding; smart00881 1156913001241 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1156913001242 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1156913001243 tRNA; other site 1156913001244 putative tRNA binding site [nucleotide binding]; other site 1156913001245 putative NADP binding site [chemical binding]; other site 1156913001246 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1156913001247 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1156913001248 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1156913001249 domain interfaces; other site 1156913001250 active site 1156913001251 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1156913001252 active site 1156913001253 homodimer interface [polypeptide binding]; other site 1156913001254 SAM binding site [chemical binding]; other site 1156913001255 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1156913001256 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1156913001257 active site 1156913001258 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1156913001259 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1156913001260 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1156913001261 dimer interface [polypeptide binding]; other site 1156913001262 active site 1156913001263 Schiff base residues; other site 1156913001264 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1156913001265 TspO/MBR family; Region: TspO_MBR; cl01379 1156913001266 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1156913001267 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913001268 inhibitor-cofactor binding pocket; inhibition site 1156913001269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913001270 catalytic residue [active] 1156913001271 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1156913001272 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913001273 catalytic core [active] 1156913001274 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1156913001275 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1156913001276 catalytic residues [active] 1156913001277 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1156913001278 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1156913001279 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1156913001280 ResB-like family; Region: ResB; pfam05140 1156913001281 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1156913001282 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1156913001283 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1156913001284 DNA binding residues [nucleotide binding] 1156913001285 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913001286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913001287 putative DNA binding site [nucleotide binding]; other site 1156913001288 putative Zn2+ binding site [ion binding]; other site 1156913001289 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913001290 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1156913001291 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1156913001292 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913001293 catalytic residue [active] 1156913001294 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1156913001295 UbiA prenyltransferase family; Region: UbiA; pfam01040 1156913001296 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913001297 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1156913001298 acyl-activating enzyme (AAE) consensus motif; other site 1156913001299 AMP binding site [chemical binding]; other site 1156913001300 active site 1156913001301 CoA binding site [chemical binding]; other site 1156913001302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913001303 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1156913001304 substrate binding site [chemical binding]; other site 1156913001305 oxyanion hole (OAH) forming residues; other site 1156913001306 trimer interface [polypeptide binding]; other site 1156913001307 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1156913001308 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1156913001309 dimer interface [polypeptide binding]; other site 1156913001310 tetramer interface [polypeptide binding]; other site 1156913001311 PYR/PP interface [polypeptide binding]; other site 1156913001312 TPP binding site [chemical binding]; other site 1156913001313 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1156913001314 TPP-binding site; other site 1156913001315 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1156913001316 Peptidase family M1; Region: Peptidase_M1; pfam01433 1156913001317 Zn binding site [ion binding]; other site 1156913001318 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1156913001319 active site 1156913001320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913001321 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1156913001322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913001323 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1156913001324 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913001325 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1156913001326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913001327 S-adenosylmethionine binding site [chemical binding]; other site 1156913001328 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1156913001329 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913001330 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1156913001331 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1156913001332 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1156913001333 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1156913001334 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1156913001335 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1156913001336 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1156913001337 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1156913001338 putative dimer interface [polypeptide binding]; other site 1156913001339 [2Fe-2S] cluster binding site [ion binding]; other site 1156913001340 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1156913001341 SLBB domain; Region: SLBB; pfam10531 1156913001342 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1156913001343 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1156913001344 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913001345 catalytic loop [active] 1156913001346 iron binding site [ion binding]; other site 1156913001347 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1156913001348 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1156913001349 molybdopterin cofactor binding site; other site 1156913001350 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1156913001351 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1156913001352 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1156913001353 4Fe-4S binding domain; Region: Fer4; pfam00037 1156913001354 4Fe-4S binding domain; Region: Fer4; pfam00037 1156913001355 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1156913001356 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1156913001357 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 1156913001358 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1156913001359 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1156913001360 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1156913001361 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1156913001362 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1156913001363 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1156913001364 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1156913001365 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1156913001366 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913001367 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913001368 EspG family; Region: ESX-1_EspG; pfam14011 1156913001369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913001370 Walker A/P-loop; other site 1156913001371 ATP binding site [chemical binding]; other site 1156913001372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913001373 ABC transporter signature motif; other site 1156913001374 Walker B; other site 1156913001375 D-loop; other site 1156913001376 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913001377 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1156913001378 active site 1156913001379 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1156913001380 putative hydrophobic ligand binding site [chemical binding]; other site 1156913001381 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1156913001382 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1156913001383 substrate binding pocket [chemical binding]; other site 1156913001384 chain length determination region; other site 1156913001385 substrate-Mg2+ binding site; other site 1156913001386 catalytic residues [active] 1156913001387 aspartate-rich region 1; other site 1156913001388 active site lid residues [active] 1156913001389 aspartate-rich region 2; other site 1156913001390 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1156913001391 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1156913001392 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1156913001393 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1156913001394 TPP-binding site [chemical binding]; other site 1156913001395 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1156913001396 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1156913001397 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1156913001398 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1156913001399 dimer interface [polypeptide binding]; other site 1156913001400 PYR/PP interface [polypeptide binding]; other site 1156913001401 TPP binding site [chemical binding]; other site 1156913001402 substrate binding site [chemical binding]; other site 1156913001403 enoyl-CoA hydratase; Provisional; Region: PRK05870 1156913001404 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913001405 substrate binding site [chemical binding]; other site 1156913001406 oxyanion hole (OAH) forming residues; other site 1156913001407 trimer interface [polypeptide binding]; other site 1156913001408 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1156913001409 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1156913001410 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913001411 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1156913001412 Amidinotransferase; Region: Amidinotransf; pfam02274 1156913001413 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1156913001414 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1156913001415 putative active site [active] 1156913001416 putative metal binding site [ion binding]; other site 1156913001417 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 1156913001418 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1156913001419 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1156913001420 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1156913001421 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1156913001422 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1156913001423 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1156913001424 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913001425 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1156913001426 Mnd1 family; Region: Mnd1; pfam03962 1156913001427 Chain length determinant protein; Region: Wzz; cl15801 1156913001428 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1156913001429 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1156913001430 active site 1156913001431 dimer interface [polypeptide binding]; other site 1156913001432 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1156913001433 Ligand Binding Site [chemical binding]; other site 1156913001434 Molecular Tunnel; other site 1156913001435 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1156913001436 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1156913001437 putative NAD(P) binding site [chemical binding]; other site 1156913001438 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1156913001439 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913001440 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1156913001441 Right handed beta helix region; Region: Beta_helix; pfam13229 1156913001442 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1156913001443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913001444 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1156913001445 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1156913001446 active site 1156913001447 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1156913001448 Right handed beta helix region; Region: Beta_helix; pfam13229 1156913001449 Right handed beta helix region; Region: Beta_helix; pfam13229 1156913001450 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 1156913001451 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913001452 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913001453 catalytic residue [active] 1156913001454 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1156913001455 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1156913001456 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1156913001457 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1156913001458 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1156913001459 active site 1156913001460 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 1156913001461 M28 Zn-Peptidases; Region: M28_like_3; cd05644 1156913001462 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 1156913001463 active site 1156913001464 metal binding site [ion binding]; metal-binding site 1156913001465 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1156913001466 extended (e) SDRs; Region: SDR_e; cd08946 1156913001467 NAD(P) binding site [chemical binding]; other site 1156913001468 active site 1156913001469 substrate binding site [chemical binding]; other site 1156913001470 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1156913001471 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1156913001472 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913001473 active site 1156913001474 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1156913001475 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913001476 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1156913001477 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1156913001478 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1156913001479 active site 1156913001480 catalytic residues [active] 1156913001481 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1156913001482 active site 1156913001483 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1156913001484 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1156913001485 heat shock protein HtpX; Provisional; Region: PRK03072 1156913001486 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913001487 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1156913001488 active site 1156913001489 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1156913001490 non-prolyl cis peptide bond; other site 1156913001491 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1156913001492 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1156913001493 substrate binding site; other site 1156913001494 tetramer interface; other site 1156913001495 BNR repeat-like domain; Region: BNR_2; pfam13088 1156913001496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1156913001497 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1156913001498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913001499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913001500 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913001501 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913001502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913001503 S-adenosylmethionine binding site [chemical binding]; other site 1156913001504 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1156913001505 RibD C-terminal domain; Region: RibD_C; cl17279 1156913001506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913001507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913001508 Coenzyme A binding pocket [chemical binding]; other site 1156913001509 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1156913001510 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 1156913001511 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1156913001512 putative dimer interface [polypeptide binding]; other site 1156913001513 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913001514 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913001515 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1156913001516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913001517 dimerization interface [polypeptide binding]; other site 1156913001518 putative DNA binding site [nucleotide binding]; other site 1156913001519 putative Zn2+ binding site [ion binding]; other site 1156913001520 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913001521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913001522 active site 1156913001523 phosphorylation site [posttranslational modification] 1156913001524 intermolecular recognition site; other site 1156913001525 dimerization interface [polypeptide binding]; other site 1156913001526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913001527 DNA binding residues [nucleotide binding] 1156913001528 dimerization interface [polypeptide binding]; other site 1156913001529 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913001530 Histidine kinase; Region: HisKA_3; pfam07730 1156913001531 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1156913001532 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1156913001533 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1156913001534 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1156913001535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913001536 Walker A motif; other site 1156913001537 ATP binding site [chemical binding]; other site 1156913001538 Walker B motif; other site 1156913001539 arginine finger; other site 1156913001540 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1156913001541 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1156913001542 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1156913001543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913001544 Coenzyme A binding pocket [chemical binding]; other site 1156913001545 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1156913001546 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1156913001547 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913001548 metal binding site [ion binding]; metal-binding site 1156913001549 active site 1156913001550 I-site; other site 1156913001551 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1156913001552 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1156913001553 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1156913001554 active site 1156913001555 catalytic site [active] 1156913001556 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1156913001557 active site 1156913001558 catalytic site [active] 1156913001559 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1156913001560 active site 1156913001561 catalytic triad [active] 1156913001562 oxyanion hole [active] 1156913001563 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1156913001564 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913001565 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1156913001566 aspartate aminotransferase; Provisional; Region: PRK05764 1156913001567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913001568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913001569 homodimer interface [polypeptide binding]; other site 1156913001570 catalytic residue [active] 1156913001571 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1156913001572 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1156913001573 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1156913001574 putative homodimer interface [polypeptide binding]; other site 1156913001575 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1156913001576 heterodimer interface [polypeptide binding]; other site 1156913001577 homodimer interface [polypeptide binding]; other site 1156913001578 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1156913001579 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1156913001580 23S rRNA interface [nucleotide binding]; other site 1156913001581 putative thiostrepton binding site; other site 1156913001582 L7/L12 interface [polypeptide binding]; other site 1156913001583 L25 interface [polypeptide binding]; other site 1156913001584 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1156913001585 mRNA/rRNA interface [nucleotide binding]; other site 1156913001586 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913001587 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1156913001588 23S rRNA interface [nucleotide binding]; other site 1156913001589 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1156913001590 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1156913001591 core dimer interface [polypeptide binding]; other site 1156913001592 peripheral dimer interface [polypeptide binding]; other site 1156913001593 L10 interface [polypeptide binding]; other site 1156913001594 L11 interface [polypeptide binding]; other site 1156913001595 putative EF-Tu interaction site [polypeptide binding]; other site 1156913001596 putative EF-G interaction site [polypeptide binding]; other site 1156913001597 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1156913001598 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1156913001599 Walker A/P-loop; other site 1156913001600 ATP binding site [chemical binding]; other site 1156913001601 Q-loop/lid; other site 1156913001602 ABC transporter signature motif; other site 1156913001603 Walker B; other site 1156913001604 D-loop; other site 1156913001605 H-loop/switch region; other site 1156913001606 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1156913001607 Permease; Region: Permease; pfam02405 1156913001608 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1156913001609 Permease; Region: Permease; pfam02405 1156913001610 mce related protein; Region: MCE; pfam02470 1156913001611 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1156913001612 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913001613 mce related protein; Region: MCE; pfam02470 1156913001614 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1156913001615 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913001616 mce related protein; Region: MCE; pfam02470 1156913001617 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1156913001618 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913001619 mce related protein; Region: MCE; pfam02470 1156913001620 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913001621 mce related protein; Region: MCE; pfam02470 1156913001622 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913001623 mce related protein; Region: MCE; pfam02470 1156913001624 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1156913001625 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1156913001626 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1156913001627 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1156913001628 RPB1 interaction site [polypeptide binding]; other site 1156913001629 RPB10 interaction site [polypeptide binding]; other site 1156913001630 RPB11 interaction site [polypeptide binding]; other site 1156913001631 RPB3 interaction site [polypeptide binding]; other site 1156913001632 RPB12 interaction site [polypeptide binding]; other site 1156913001633 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1156913001634 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1156913001635 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1156913001636 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1156913001637 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1156913001638 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1156913001639 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1156913001640 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1156913001641 DNA binding site [nucleotide binding] 1156913001642 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1156913001643 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913001644 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913001645 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 1156913001646 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913001647 Coenzyme A binding pocket [chemical binding]; other site 1156913001648 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1156913001649 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1156913001650 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1156913001651 S17 interaction site [polypeptide binding]; other site 1156913001652 S8 interaction site; other site 1156913001653 16S rRNA interaction site [nucleotide binding]; other site 1156913001654 streptomycin interaction site [chemical binding]; other site 1156913001655 23S rRNA interaction site [nucleotide binding]; other site 1156913001656 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1156913001657 30S ribosomal protein S7; Validated; Region: PRK05302 1156913001658 elongation factor G; Reviewed; Region: PRK00007 1156913001659 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1156913001660 G1 box; other site 1156913001661 putative GEF interaction site [polypeptide binding]; other site 1156913001662 GTP/Mg2+ binding site [chemical binding]; other site 1156913001663 Switch I region; other site 1156913001664 G2 box; other site 1156913001665 G3 box; other site 1156913001666 Switch II region; other site 1156913001667 G4 box; other site 1156913001668 G5 box; other site 1156913001669 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1156913001670 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1156913001671 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1156913001672 elongation factor Tu; Reviewed; Region: PRK00049 1156913001673 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1156913001674 G1 box; other site 1156913001675 GEF interaction site [polypeptide binding]; other site 1156913001676 GTP/Mg2+ binding site [chemical binding]; other site 1156913001677 Switch I region; other site 1156913001678 G2 box; other site 1156913001679 G3 box; other site 1156913001680 Switch II region; other site 1156913001681 G4 box; other site 1156913001682 G5 box; other site 1156913001683 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1156913001684 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1156913001685 Antibiotic Binding Site [chemical binding]; other site 1156913001686 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1156913001687 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1156913001688 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1156913001689 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1156913001690 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1156913001691 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1156913001692 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1156913001693 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1156913001694 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1156913001695 putative translocon binding site; other site 1156913001696 protein-rRNA interface [nucleotide binding]; other site 1156913001697 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1156913001698 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1156913001699 G-X-X-G motif; other site 1156913001700 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1156913001701 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1156913001702 23S rRNA interface [nucleotide binding]; other site 1156913001703 5S rRNA interface [nucleotide binding]; other site 1156913001704 putative antibiotic binding site [chemical binding]; other site 1156913001705 L25 interface [polypeptide binding]; other site 1156913001706 L27 interface [polypeptide binding]; other site 1156913001707 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1156913001708 23S rRNA interface [nucleotide binding]; other site 1156913001709 putative translocon interaction site; other site 1156913001710 signal recognition particle (SRP54) interaction site; other site 1156913001711 L23 interface [polypeptide binding]; other site 1156913001712 trigger factor interaction site; other site 1156913001713 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1156913001714 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1156913001715 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1156913001716 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1156913001717 RNA binding site [nucleotide binding]; other site 1156913001718 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1156913001719 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1156913001720 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1156913001721 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1156913001722 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1156913001723 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1156913001724 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1156913001725 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1156913001726 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1156913001727 5S rRNA interface [nucleotide binding]; other site 1156913001728 L27 interface [polypeptide binding]; other site 1156913001729 23S rRNA interface [nucleotide binding]; other site 1156913001730 L5 interface [polypeptide binding]; other site 1156913001731 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1156913001732 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1156913001733 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1156913001734 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1156913001735 23S rRNA binding site [nucleotide binding]; other site 1156913001736 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1156913001737 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1156913001738 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1156913001739 SecY translocase; Region: SecY; pfam00344 1156913001740 adenylate kinase; Reviewed; Region: adk; PRK00279 1156913001741 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1156913001742 AMP-binding site [chemical binding]; other site 1156913001743 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1156913001744 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1156913001745 active site 1156913001746 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1156913001747 rRNA binding site [nucleotide binding]; other site 1156913001748 predicted 30S ribosome binding site; other site 1156913001749 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1156913001750 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1156913001751 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1156913001752 30S ribosomal protein S11; Validated; Region: PRK05309 1156913001753 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1156913001754 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1156913001755 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1156913001756 RNA binding surface [nucleotide binding]; other site 1156913001757 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1156913001758 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1156913001759 alphaNTD homodimer interface [polypeptide binding]; other site 1156913001760 alphaNTD - beta interaction site [polypeptide binding]; other site 1156913001761 alphaNTD - beta' interaction site [polypeptide binding]; other site 1156913001762 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1156913001763 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1156913001764 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1156913001765 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1156913001766 active site 1156913001767 dimerization interface 3.5A [polypeptide binding]; other site 1156913001768 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1156913001769 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1156913001770 putative active site [active] 1156913001771 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1156913001772 Protein of unknown function (DUF690); Region: DUF690; cl04939 1156913001773 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1156913001774 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1156913001775 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1156913001776 catalytic residues [active] 1156913001777 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1156913001778 active site 1156913001779 catalytic residues [active] 1156913001780 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1156913001781 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1156913001782 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913001783 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1156913001784 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913001785 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913001786 nucleotide binding site [chemical binding]; other site 1156913001787 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913001788 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1156913001789 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1156913001790 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1156913001791 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1156913001792 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1156913001793 23S rRNA interface [nucleotide binding]; other site 1156913001794 L3 interface [polypeptide binding]; other site 1156913001795 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1156913001796 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1156913001797 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1156913001798 active site 1156913001799 substrate binding site [chemical binding]; other site 1156913001800 metal binding site [ion binding]; metal-binding site 1156913001801 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913001802 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1156913001803 acyl-CoA synthetase; Validated; Region: PRK05850 1156913001804 acyl-activating enzyme (AAE) consensus motif; other site 1156913001805 active site 1156913001806 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913001807 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913001808 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1156913001809 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1156913001810 glutaminase active site [active] 1156913001811 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1156913001812 dimer interface [polypeptide binding]; other site 1156913001813 active site 1156913001814 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1156913001815 dimer interface [polypeptide binding]; other site 1156913001816 active site 1156913001817 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1156913001818 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1156913001819 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1156913001820 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1156913001821 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1156913001822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913001823 nucleotide binding site [chemical binding]; other site 1156913001824 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1156913001825 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1156913001826 Walker A/P-loop; other site 1156913001827 ATP binding site [chemical binding]; other site 1156913001828 Q-loop/lid; other site 1156913001829 ABC transporter signature motif; other site 1156913001830 Walker B; other site 1156913001831 D-loop; other site 1156913001832 H-loop/switch region; other site 1156913001833 TOBE domain; Region: TOBE_2; pfam08402 1156913001834 alanine racemase; Reviewed; Region: alr; PRK00053 1156913001835 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1156913001836 active site 1156913001837 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1156913001838 dimer interface [polypeptide binding]; other site 1156913001839 substrate binding site [chemical binding]; other site 1156913001840 catalytic residues [active] 1156913001841 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913001842 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913001843 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913001844 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1156913001845 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1156913001846 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1156913001847 acyl-CoA synthetase; Validated; Region: PRK07787 1156913001848 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913001849 acyl-activating enzyme (AAE) consensus motif; other site 1156913001850 AMP binding site [chemical binding]; other site 1156913001851 active site 1156913001852 CoA binding site [chemical binding]; other site 1156913001853 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1156913001854 Glycoprotease family; Region: Peptidase_M22; pfam00814 1156913001855 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1156913001856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913001857 Coenzyme A binding pocket [chemical binding]; other site 1156913001858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1156913001859 UGMP family protein; Validated; Region: PRK09604 1156913001860 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1156913001861 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 1156913001862 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1156913001863 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1156913001864 active site 1156913001865 homodimer interface [polypeptide binding]; other site 1156913001866 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1156913001867 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1156913001868 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913001869 active site 1156913001870 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913001871 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1156913001872 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1156913001873 amidase catalytic site [active] 1156913001874 Zn binding residues [ion binding]; other site 1156913001875 substrate binding site [chemical binding]; other site 1156913001876 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1156913001877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913001878 motif II; other site 1156913001879 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1156913001880 active site 1156913001881 catalytic residues [active] 1156913001882 DNA binding site [nucleotide binding] 1156913001883 Int/Topo IB signature motif; other site 1156913001884 Helix-turn-helix domain; Region: HTH_17; pfam12728 1156913001885 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913001886 Flavoprotein; Region: Flavoprotein; pfam02441 1156913001887 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1156913001888 oligomerisation interface [polypeptide binding]; other site 1156913001889 mobile loop; other site 1156913001890 roof hairpin; other site 1156913001891 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1156913001892 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1156913001893 ring oligomerisation interface [polypeptide binding]; other site 1156913001894 ATP/Mg binding site [chemical binding]; other site 1156913001895 stacking interactions; other site 1156913001896 hinge regions; other site 1156913001897 Transcription factor WhiB; Region: Whib; pfam02467 1156913001898 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913001899 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1156913001900 DNA binding residues [nucleotide binding] 1156913001901 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913001902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913001903 active site 1156913001904 phosphorylation site [posttranslational modification] 1156913001905 intermolecular recognition site; other site 1156913001906 dimerization interface [polypeptide binding]; other site 1156913001907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913001908 DNA binding residues [nucleotide binding] 1156913001909 dimerization interface [polypeptide binding]; other site 1156913001910 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1156913001911 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913001912 DNA binding residues [nucleotide binding] 1156913001913 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1156913001914 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1156913001915 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1156913001916 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1156913001917 active site 1156913001918 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1156913001919 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1156913001920 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1156913001921 phosphate binding site [ion binding]; other site 1156913001922 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1156913001923 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1156913001924 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1156913001925 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1156913001926 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1156913001927 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1156913001928 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1156913001929 siderophore binding site; other site 1156913001930 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1156913001931 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913001932 ABC-ATPase subunit interface; other site 1156913001933 dimer interface [polypeptide binding]; other site 1156913001934 putative PBP binding regions; other site 1156913001935 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1156913001936 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913001937 dimer interface [polypeptide binding]; other site 1156913001938 putative PBP binding regions; other site 1156913001939 ABC-ATPase subunit interface; other site 1156913001940 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1156913001941 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1156913001942 Walker A/P-loop; other site 1156913001943 ATP binding site [chemical binding]; other site 1156913001944 Q-loop/lid; other site 1156913001945 ABC transporter signature motif; other site 1156913001946 Walker B; other site 1156913001947 D-loop; other site 1156913001948 H-loop/switch region; other site 1156913001949 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1156913001950 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913001951 Berberine and berberine like; Region: BBE; pfam08031 1156913001952 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913001953 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913001954 NAD(P) binding site [chemical binding]; other site 1156913001955 catalytic residues [active] 1156913001956 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1156913001957 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1156913001958 catalytic Zn binding site [ion binding]; other site 1156913001959 NAD(P) binding site [chemical binding]; other site 1156913001960 structural Zn binding site [ion binding]; other site 1156913001961 DinB superfamily; Region: DinB_2; pfam12867 1156913001962 GMP synthase; Reviewed; Region: guaA; PRK00074 1156913001963 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1156913001964 AMP/PPi binding site [chemical binding]; other site 1156913001965 candidate oxyanion hole; other site 1156913001966 catalytic triad [active] 1156913001967 potential glutamine specificity residues [chemical binding]; other site 1156913001968 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1156913001969 ATP Binding subdomain [chemical binding]; other site 1156913001970 Ligand Binding sites [chemical binding]; other site 1156913001971 Dimerization subdomain; other site 1156913001972 PspC domain; Region: PspC; cl00864 1156913001973 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1156913001974 PspC domain; Region: PspC; pfam04024 1156913001975 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913001976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913001977 ATP binding site [chemical binding]; other site 1156913001978 Mg2+ binding site [ion binding]; other site 1156913001979 G-X-G motif; other site 1156913001980 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913001981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913001982 active site 1156913001983 phosphorylation site [posttranslational modification] 1156913001984 intermolecular recognition site; other site 1156913001985 dimerization interface [polypeptide binding]; other site 1156913001986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913001987 DNA binding residues [nucleotide binding] 1156913001988 dimerization interface [polypeptide binding]; other site 1156913001989 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1156913001990 EamA-like transporter family; Region: EamA; pfam00892 1156913001991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913001992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913001993 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1156913001994 putative dimerization interface [polypeptide binding]; other site 1156913001995 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1156913001996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913001997 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913001998 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913001999 active site 1156913002000 ATP binding site [chemical binding]; other site 1156913002001 substrate binding site [chemical binding]; other site 1156913002002 activation loop (A-loop); other site 1156913002003 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913002004 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913002005 active site 1156913002006 ATP binding site [chemical binding]; other site 1156913002007 substrate binding site [chemical binding]; other site 1156913002008 activation loop (A-loop); other site 1156913002009 Chorismate mutase type II; Region: CM_2; cl00693 1156913002010 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1156913002011 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1156913002012 Part of AAA domain; Region: AAA_19; pfam13245 1156913002013 Family description; Region: UvrD_C_2; pfam13538 1156913002014 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1156913002015 Peptidase family M23; Region: Peptidase_M23; pfam01551 1156913002016 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1156913002017 B12 binding site [chemical binding]; other site 1156913002018 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1156913002019 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1156913002020 CoA-ligase; Region: Ligase_CoA; pfam00549 1156913002021 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1156913002022 CoA binding domain; Region: CoA_binding; smart00881 1156913002023 CoA-ligase; Region: Ligase_CoA; pfam00549 1156913002024 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1156913002025 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1156913002026 active site 1156913002027 substrate binding site [chemical binding]; other site 1156913002028 cosubstrate binding site; other site 1156913002029 catalytic site [active] 1156913002030 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1156913002031 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1156913002032 purine monophosphate binding site [chemical binding]; other site 1156913002033 dimer interface [polypeptide binding]; other site 1156913002034 putative catalytic residues [active] 1156913002035 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1156913002036 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1156913002037 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1156913002038 putative hydrophobic ligand binding site [chemical binding]; other site 1156913002039 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1156913002040 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1156913002041 putative dimer interface [polypeptide binding]; other site 1156913002042 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913002043 HD domain; Region: HD; pfam01966 1156913002044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913002045 salt bridge; other site 1156913002046 non-specific DNA binding site [nucleotide binding]; other site 1156913002047 sequence-specific DNA binding site [nucleotide binding]; other site 1156913002048 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1156913002049 DNA Polymerase Y-family; Region: PolY_like; cd03468 1156913002050 active site 1156913002051 DNA binding site [nucleotide binding] 1156913002052 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1156913002053 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1156913002054 active site 1156913002055 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1156913002056 generic binding surface I; other site 1156913002057 generic binding surface II; other site 1156913002058 Hemerythrin-like domain; Region: Hr-like; cd12108 1156913002059 Fe binding site [ion binding]; other site 1156913002060 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1156913002061 putative dimer interface [polypeptide binding]; other site 1156913002062 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913002063 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1156913002064 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1156913002065 putative active site [active] 1156913002066 putative NTP binding site [chemical binding]; other site 1156913002067 putative nucleic acid binding site [nucleotide binding]; other site 1156913002068 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1156913002069 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1156913002070 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1156913002071 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1156913002072 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1156913002073 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1156913002074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913002075 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913002076 putative substrate translocation pore; other site 1156913002077 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913002078 dimerization interface [polypeptide binding]; other site 1156913002079 putative DNA binding site [nucleotide binding]; other site 1156913002080 putative Zn2+ binding site [ion binding]; other site 1156913002081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913002082 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1156913002083 putative substrate translocation pore; other site 1156913002084 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 1156913002085 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1156913002086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1156913002087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913002088 Coenzyme A binding pocket [chemical binding]; other site 1156913002089 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1156913002090 minor groove reading motif; other site 1156913002091 helix-hairpin-helix signature motif; other site 1156913002092 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1156913002093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913002094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913002095 dimerization interface [polypeptide binding]; other site 1156913002096 Lysine efflux permease [General function prediction only]; Region: COG1279 1156913002097 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913002098 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913002099 active site 1156913002100 catalytic tetrad [active] 1156913002101 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913002102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913002103 NAD(P) binding site [chemical binding]; other site 1156913002104 active site 1156913002105 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913002106 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1156913002107 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913002108 Lipase (class 2); Region: Lipase_2; pfam01674 1156913002109 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 1156913002110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913002111 S-adenosylmethionine binding site [chemical binding]; other site 1156913002112 isocitrate dehydrogenase; Validated; Region: PRK08299 1156913002113 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1156913002114 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1156913002115 putative active site [active] 1156913002116 putative catalytic site [active] 1156913002117 putative DNA binding site [nucleotide binding]; other site 1156913002118 putative phosphate binding site [ion binding]; other site 1156913002119 metal binding site A [ion binding]; metal-binding site 1156913002120 putative AP binding site [nucleotide binding]; other site 1156913002121 putative metal binding site B [ion binding]; other site 1156913002122 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1156913002123 active site 1156913002124 NTP binding site [chemical binding]; other site 1156913002125 metal binding triad [ion binding]; metal-binding site 1156913002126 antibiotic binding site [chemical binding]; other site 1156913002127 Cupin domain; Region: Cupin_2; pfam07883 1156913002128 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913002129 MarR family; Region: MarR_2; pfam12802 1156913002130 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1156913002131 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1156913002132 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1156913002133 putative sugar binding site [chemical binding]; other site 1156913002134 catalytic residues [active] 1156913002135 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1156913002136 cleavage site 1156913002137 active site 1156913002138 substrate binding sites [chemical binding]; other site 1156913002139 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1156913002140 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1156913002141 active site 1156913002142 HIGH motif; other site 1156913002143 dimer interface [polypeptide binding]; other site 1156913002144 KMSKS motif; other site 1156913002145 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1156913002146 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1156913002147 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1156913002148 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1156913002149 active site 1156913002150 catalytic residues [active] 1156913002151 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1156913002152 active site 1156913002153 Zn binding site [ion binding]; other site 1156913002154 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1156913002155 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1156913002156 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1156913002157 L-aspartate oxidase; Provisional; Region: PRK06175 1156913002158 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1156913002159 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1156913002160 putative Iron-sulfur protein interface [polypeptide binding]; other site 1156913002161 putative proximal heme binding site [chemical binding]; other site 1156913002162 putative SdhC-like subunit interface [polypeptide binding]; other site 1156913002163 putative distal heme binding site [chemical binding]; other site 1156913002164 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1156913002165 putative Iron-sulfur protein interface [polypeptide binding]; other site 1156913002166 putative proximal heme binding site [chemical binding]; other site 1156913002167 putative SdhD-like interface [polypeptide binding]; other site 1156913002168 putative distal heme binding site [chemical binding]; other site 1156913002169 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1156913002170 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1156913002171 ligand binding site [chemical binding]; other site 1156913002172 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1156913002173 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1156913002174 Walker A/P-loop; other site 1156913002175 ATP binding site [chemical binding]; other site 1156913002176 Q-loop/lid; other site 1156913002177 ABC transporter signature motif; other site 1156913002178 Walker B; other site 1156913002179 D-loop; other site 1156913002180 H-loop/switch region; other site 1156913002181 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1156913002182 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913002183 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1156913002184 TM-ABC transporter signature motif; other site 1156913002185 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1156913002186 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913002187 TM-ABC transporter signature motif; other site 1156913002188 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1156913002189 active site 1156913002190 catalytic motif [active] 1156913002191 Zn binding site [ion binding]; other site 1156913002192 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1156913002193 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1156913002194 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1156913002195 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1156913002196 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1156913002197 adenosine deaminase; Provisional; Region: PRK09358 1156913002198 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1156913002199 active site 1156913002200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913002201 putative substrate translocation pore; other site 1156913002202 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913002203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913002204 ATP binding site [chemical binding]; other site 1156913002205 putative Mg++ binding site [ion binding]; other site 1156913002206 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913002207 nucleotide binding region [chemical binding]; other site 1156913002208 ATP-binding site [chemical binding]; other site 1156913002209 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1156913002210 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1156913002211 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1156913002212 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913002213 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913002214 putative DNA binding site [nucleotide binding]; other site 1156913002215 putative Zn2+ binding site [ion binding]; other site 1156913002216 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1156913002217 Helix-turn-helix domain; Region: HTH_28; pfam13518 1156913002218 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1156913002219 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1156913002220 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1156913002221 putative NAD(P) binding site [chemical binding]; other site 1156913002222 catalytic Zn binding site [ion binding]; other site 1156913002223 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913002224 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913002225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913002226 dimer interface [polypeptide binding]; other site 1156913002227 conserved gate region; other site 1156913002228 putative PBP binding loops; other site 1156913002229 ABC-ATPase subunit interface; other site 1156913002230 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913002231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913002232 dimer interface [polypeptide binding]; other site 1156913002233 conserved gate region; other site 1156913002234 putative PBP binding loops; other site 1156913002235 ABC-ATPase subunit interface; other site 1156913002236 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1156913002237 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1156913002238 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913002239 Cytochrome P450; Region: p450; cl12078 1156913002240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913002241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913002242 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913002243 NAD(P) binding site [chemical binding]; other site 1156913002244 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 1156913002245 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913002246 NAD(P) binding site [chemical binding]; other site 1156913002247 catalytic residues [active] 1156913002248 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1156913002249 intersubunit interface [polypeptide binding]; other site 1156913002250 active site 1156913002251 catalytic residue [active] 1156913002252 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913002253 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913002254 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1156913002255 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1156913002256 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1156913002257 active site 1156913002258 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1156913002259 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913002260 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1156913002261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913002262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913002263 WHG domain; Region: WHG; pfam13305 1156913002264 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1156913002265 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1156913002266 DNA binding residues [nucleotide binding] 1156913002267 putative dimer interface [polypeptide binding]; other site 1156913002268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913002269 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913002270 active site 1156913002271 catalytic tetrad [active] 1156913002272 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913002273 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913002274 active site 1156913002275 catalytic tetrad [active] 1156913002276 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1156913002277 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1156913002278 dimer interface [polypeptide binding]; other site 1156913002279 motif 1; other site 1156913002280 active site 1156913002281 motif 2; other site 1156913002282 motif 3; other site 1156913002283 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1156913002284 anticodon binding site; other site 1156913002285 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1156913002286 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913002287 active site 1156913002288 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cl15675 1156913002289 catalytic site [active] 1156913002290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913002291 sequence-specific DNA binding site [nucleotide binding]; other site 1156913002292 salt bridge; other site 1156913002293 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1156913002294 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1156913002295 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1156913002296 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1156913002297 active site 1156913002298 substrate binding site [chemical binding]; other site 1156913002299 metal binding site [ion binding]; metal-binding site 1156913002300 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913002301 homodimer interface [polypeptide binding]; other site 1156913002302 active site 1156913002303 TDP-binding site; other site 1156913002304 acceptor substrate-binding pocket; other site 1156913002305 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1156913002306 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 1156913002307 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913002308 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913002309 active site 1156913002310 ATP binding site [chemical binding]; other site 1156913002311 substrate binding site [chemical binding]; other site 1156913002312 activation loop (A-loop); other site 1156913002313 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1156913002314 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1156913002315 heterodimer interface [polypeptide binding]; other site 1156913002316 substrate interaction site [chemical binding]; other site 1156913002317 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1156913002318 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1156913002319 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1156913002320 active site 1156913002321 substrate binding site [chemical binding]; other site 1156913002322 coenzyme B12 binding site [chemical binding]; other site 1156913002323 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1156913002324 B12 binding site [chemical binding]; other site 1156913002325 cobalt ligand [ion binding]; other site 1156913002326 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1156913002327 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1156913002328 Walker A; other site 1156913002329 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1156913002330 Switch II region; other site 1156913002331 G4 box; other site 1156913002332 G5 box; other site 1156913002333 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1156913002334 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1156913002335 metal binding site [ion binding]; metal-binding site 1156913002336 putative dimer interface [polypeptide binding]; other site 1156913002337 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1156913002338 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1156913002339 putative active site [active] 1156913002340 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1156913002341 dimerization interface [polypeptide binding]; other site 1156913002342 putative active site pocket [active] 1156913002343 putative catalytic residue [active] 1156913002344 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1156913002345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913002346 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913002347 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1156913002348 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1156913002349 active site 1156913002350 putative catalytic site [active] 1156913002351 glycerol kinase; Provisional; Region: glpK; PRK00047 1156913002352 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1156913002353 N- and C-terminal domain interface [polypeptide binding]; other site 1156913002354 active site 1156913002355 MgATP binding site [chemical binding]; other site 1156913002356 catalytic site [active] 1156913002357 metal binding site [ion binding]; metal-binding site 1156913002358 putative homotetramer interface [polypeptide binding]; other site 1156913002359 glycerol binding site [chemical binding]; other site 1156913002360 homodimer interface [polypeptide binding]; other site 1156913002361 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1156913002362 amphipathic channel; other site 1156913002363 Asn-Pro-Ala signature motifs; other site 1156913002364 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1156913002365 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913002366 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 1156913002367 NAD(P) binding site [chemical binding]; other site 1156913002368 catalytic residues [active] 1156913002369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913002370 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1156913002371 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1156913002372 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1156913002373 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1156913002374 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1156913002375 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1156913002376 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1156913002377 carboxyltransferase (CT) interaction site; other site 1156913002378 biotinylation site [posttranslational modification]; other site 1156913002379 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 1156913002380 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1156913002381 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1156913002382 Maf-like protein; Region: Maf; pfam02545 1156913002383 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1156913002384 active site 1156913002385 dimer interface [polypeptide binding]; other site 1156913002386 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1156913002387 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1156913002388 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1156913002389 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913002390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913002391 putative substrate translocation pore; other site 1156913002392 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913002393 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1156913002394 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1156913002395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913002396 non-specific DNA binding site [nucleotide binding]; other site 1156913002397 salt bridge; other site 1156913002398 sequence-specific DNA binding site [nucleotide binding]; other site 1156913002399 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1156913002400 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1156913002401 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1156913002402 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913002403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913002404 active site 1156913002405 phosphorylation site [posttranslational modification] 1156913002406 intermolecular recognition site; other site 1156913002407 dimerization interface [polypeptide binding]; other site 1156913002408 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913002409 DNA binding residues [nucleotide binding] 1156913002410 dimerization interface [polypeptide binding]; other site 1156913002411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913002412 Histidine kinase; Region: HisKA_3; pfam07730 1156913002413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913002414 ATP binding site [chemical binding]; other site 1156913002415 Mg2+ binding site [ion binding]; other site 1156913002416 G-X-G motif; other site 1156913002417 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1156913002418 putative hydrophobic ligand binding site [chemical binding]; other site 1156913002419 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1156913002420 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1156913002421 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1156913002422 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913002423 conserved cys residue [active] 1156913002424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913002425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913002426 YhhN-like protein; Region: YhhN; cl01505 1156913002427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913002428 dimerization interface [polypeptide binding]; other site 1156913002429 putative DNA binding site [nucleotide binding]; other site 1156913002430 putative Zn2+ binding site [ion binding]; other site 1156913002431 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1156913002432 hydrophobic ligand binding site; other site 1156913002433 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1156913002434 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913002435 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1156913002436 active site 1156913002437 metal binding site [ion binding]; metal-binding site 1156913002438 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913002439 LysE type translocator; Region: LysE; cl00565 1156913002440 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1156913002441 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1156913002442 catalytic residues [active] 1156913002443 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1156913002444 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1156913002445 DNA binding residues [nucleotide binding] 1156913002446 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1156913002447 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913002448 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913002449 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1156913002450 NlpC/P60 family; Region: NLPC_P60; pfam00877 1156913002451 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1156913002452 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1156913002453 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1156913002454 Bacterial PH domain; Region: DUF304; pfam03703 1156913002455 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1156913002456 active site 1156913002457 catalytic residues [active] 1156913002458 metal binding site [ion binding]; metal-binding site 1156913002459 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1156913002460 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1156913002461 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1156913002462 active site 1156913002463 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913002464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913002465 active site 1156913002466 phosphorylation site [posttranslational modification] 1156913002467 intermolecular recognition site; other site 1156913002468 dimerization interface [polypeptide binding]; other site 1156913002469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913002470 DNA binding site [nucleotide binding] 1156913002471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913002472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913002473 ATP binding site [chemical binding]; other site 1156913002474 Mg2+ binding site [ion binding]; other site 1156913002475 G-X-G motif; other site 1156913002476 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1156913002477 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913002478 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913002479 DNA binding residues [nucleotide binding] 1156913002480 dimerization interface [polypeptide binding]; other site 1156913002481 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913002482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913002483 active site 1156913002484 phosphorylation site [posttranslational modification] 1156913002485 intermolecular recognition site; other site 1156913002486 dimerization interface [polypeptide binding]; other site 1156913002487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913002488 DNA binding residues [nucleotide binding] 1156913002489 dimerization interface [polypeptide binding]; other site 1156913002490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913002491 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1156913002492 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913002493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913002494 Predicted membrane protein [Function unknown]; Region: COG2246 1156913002495 GtrA-like protein; Region: GtrA; pfam04138 1156913002496 Predicted membrane protein [Function unknown]; Region: COG2246 1156913002497 GtrA-like protein; Region: GtrA; pfam04138 1156913002498 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913002499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913002500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913002501 DNA binding residues [nucleotide binding] 1156913002502 Putative zinc-finger; Region: zf-HC2; pfam13490 1156913002503 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1156913002504 nucleotidyl binding site; other site 1156913002505 metal binding site [ion binding]; metal-binding site 1156913002506 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1156913002507 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1156913002508 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1156913002509 ATP-grasp domain; Region: ATP-grasp; pfam02222 1156913002510 AIR carboxylase; Region: AIRC; pfam00731 1156913002511 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1156913002512 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913002513 acyl-activating enzyme (AAE) consensus motif; other site 1156913002514 AMP binding site [chemical binding]; other site 1156913002515 active site 1156913002516 CoA binding site [chemical binding]; other site 1156913002517 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913002518 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913002519 active site 1156913002520 DoxX; Region: DoxX; pfam07681 1156913002521 TIGR03089 family protein; Region: TIGR03089 1156913002522 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1156913002523 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1156913002524 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1156913002525 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1156913002526 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1156913002527 NAD binding site [chemical binding]; other site 1156913002528 substrate binding site [chemical binding]; other site 1156913002529 homodimer interface [polypeptide binding]; other site 1156913002530 active site 1156913002531 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1156913002532 NADP binding site [chemical binding]; other site 1156913002533 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1156913002534 active site 1156913002535 putative substrate binding site [chemical binding]; other site 1156913002536 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1156913002537 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913002538 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1156913002539 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1156913002540 Probable Catalytic site; other site 1156913002541 metal-binding site 1156913002542 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1156913002543 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913002544 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1156913002545 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1156913002546 Probable Catalytic site; other site 1156913002547 metal-binding site 1156913002548 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1156913002549 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913002550 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913002551 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1156913002552 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1156913002553 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1156913002554 Probable Catalytic site; other site 1156913002555 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913002556 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913002557 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913002558 cytidyltransferase-like domain; Region: cyt_tran_rel; TIGR00125 1156913002559 active site 1156913002560 nucleotide binding site [chemical binding]; other site 1156913002561 HIGH motif; other site 1156913002562 KMSKS motif; other site 1156913002563 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1156913002564 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1156913002565 minor groove reading motif; other site 1156913002566 helix-hairpin-helix signature motif; other site 1156913002567 active site 1156913002568 Predicted transcriptional regulators [Transcription]; Region: COG1725 1156913002569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913002570 DNA-binding site [nucleotide binding]; DNA binding site 1156913002571 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1156913002572 nudix motif; other site 1156913002573 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1156913002574 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 1156913002575 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1156913002576 putative FMN binding site [chemical binding]; other site 1156913002577 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1156913002578 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1156913002579 phosphate binding site [ion binding]; other site 1156913002580 dimer interface [polypeptide binding]; other site 1156913002581 substrate binding site [chemical binding]; other site 1156913002582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913002583 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1156913002584 Coenzyme A binding pocket [chemical binding]; other site 1156913002585 Ferredoxin [Energy production and conversion]; Region: COG1146 1156913002586 4Fe-4S binding domain; Region: Fer4; pfam00037 1156913002587 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1156913002588 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913002589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913002590 homodimer interface [polypeptide binding]; other site 1156913002591 catalytic residue [active] 1156913002592 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913002593 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1156913002594 hypothetical protein; Provisional; Region: PRK06184 1156913002595 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913002596 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1156913002597 CHAD domain; Region: CHAD; pfam05235 1156913002598 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1156913002599 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1156913002600 putative trimer interface [polypeptide binding]; other site 1156913002601 putative CoA binding site [chemical binding]; other site 1156913002602 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1156913002603 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1156913002604 metal binding site [ion binding]; metal-binding site 1156913002605 putative dimer interface [polypeptide binding]; other site 1156913002606 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1156913002607 Phosphotransferase enzyme family; Region: APH; pfam01636 1156913002608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1156913002609 sequence-specific DNA binding site [nucleotide binding]; other site 1156913002610 salt bridge; other site 1156913002611 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1156913002612 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1156913002613 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1156913002614 putative active site [active] 1156913002615 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1156913002616 Peptidase family M28; Region: Peptidase_M28; pfam04389 1156913002617 active site 1156913002618 metal binding site [ion binding]; metal-binding site 1156913002619 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1156913002620 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1156913002621 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1156913002622 active site 1156913002623 Zn binding site [ion binding]; other site 1156913002624 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1156913002625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913002626 sequence-specific DNA binding site [nucleotide binding]; other site 1156913002627 salt bridge; other site 1156913002628 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1156913002629 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1156913002630 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1156913002631 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1156913002632 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1156913002633 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1156913002634 putative acyl-acceptor binding pocket; other site 1156913002635 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1156913002636 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1156913002637 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1156913002638 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1156913002639 Walker A/P-loop; other site 1156913002640 ATP binding site [chemical binding]; other site 1156913002641 Q-loop/lid; other site 1156913002642 ABC transporter signature motif; other site 1156913002643 Walker B; other site 1156913002644 D-loop; other site 1156913002645 H-loop/switch region; other site 1156913002646 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913002647 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913002648 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1156913002649 Walker A/P-loop; other site 1156913002650 ATP binding site [chemical binding]; other site 1156913002651 Q-loop/lid; other site 1156913002652 ABC transporter signature motif; other site 1156913002653 Walker B; other site 1156913002654 D-loop; other site 1156913002655 H-loop/switch region; other site 1156913002656 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1156913002657 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1156913002658 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1156913002659 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913002660 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1156913002661 DivIVA domain; Region: DivI1A_domain; TIGR03544 1156913002662 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1156913002663 hydrophobic ligand binding site; other site 1156913002664 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1156913002665 enoyl-CoA hydratase; Provisional; Region: PRK06688 1156913002666 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913002667 substrate binding site [chemical binding]; other site 1156913002668 oxyanion hole (OAH) forming residues; other site 1156913002669 trimer interface [polypeptide binding]; other site 1156913002670 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1156913002671 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1156913002672 interface (dimer of trimers) [polypeptide binding]; other site 1156913002673 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1156913002674 Substrate-binding/catalytic site; other site 1156913002675 Zn-binding sites [ion binding]; other site 1156913002676 PAP2 superfamily; Region: PAP2; pfam01569 1156913002677 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1156913002678 active site 1156913002679 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913002680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913002681 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1156913002682 putative dimerization interface [polypeptide binding]; other site 1156913002683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913002684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913002685 putative substrate translocation pore; other site 1156913002686 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913002687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913002688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913002689 DNA binding residues [nucleotide binding] 1156913002690 Putative zinc-finger; Region: zf-HC2; pfam13490 1156913002691 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1156913002692 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1156913002693 sec-independent translocase; Provisional; Region: PRK03100 1156913002694 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1156913002695 antiporter inner membrane protein; Provisional; Region: PRK11670 1156913002696 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1156913002697 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1156913002698 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1156913002699 PRC-barrel domain; Region: PRC; pfam05239 1156913002700 MgtE intracellular N domain; Region: MgtE_N; smart00924 1156913002701 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1156913002702 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1156913002703 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1156913002704 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1156913002705 Abi-like protein; Region: Abi_2; cl01988 1156913002706 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1156913002707 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1156913002708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913002709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913002710 active site 1156913002711 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913002712 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913002713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913002714 dimer interface [polypeptide binding]; other site 1156913002715 conserved gate region; other site 1156913002716 putative PBP binding loops; other site 1156913002717 ABC-ATPase subunit interface; other site 1156913002718 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913002719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913002720 dimer interface [polypeptide binding]; other site 1156913002721 conserved gate region; other site 1156913002722 putative PBP binding loops; other site 1156913002723 ABC-ATPase subunit interface; other site 1156913002724 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1156913002725 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1156913002726 Walker A/P-loop; other site 1156913002727 ATP binding site [chemical binding]; other site 1156913002728 Q-loop/lid; other site 1156913002729 ABC transporter signature motif; other site 1156913002730 Walker B; other site 1156913002731 D-loop; other site 1156913002732 H-loop/switch region; other site 1156913002733 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 1156913002734 PspC domain; Region: PspC; pfam04024 1156913002735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913002736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913002737 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913002738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913002739 putative substrate translocation pore; other site 1156913002740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913002741 ParB-like nuclease domain; Region: ParBc; cl02129 1156913002742 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913002743 active site 1156913002744 metal binding site [ion binding]; metal-binding site 1156913002745 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913002746 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1156913002747 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1156913002748 oligomer interface [polypeptide binding]; other site 1156913002749 metal binding site [ion binding]; metal-binding site 1156913002750 metal binding site [ion binding]; metal-binding site 1156913002751 putative Cl binding site [ion binding]; other site 1156913002752 basic sphincter; other site 1156913002753 hydrophobic gate; other site 1156913002754 periplasmic entrance; other site 1156913002755 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1156913002756 putative active site [active] 1156913002757 putative catalytic site [active] 1156913002758 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 1156913002759 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 1156913002760 nudix motif; other site 1156913002761 Bacterial PH domain; Region: DUF304; pfam03703 1156913002762 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1156913002763 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1156913002764 active site 1156913002765 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1156913002766 MarC family integral membrane protein; Region: MarC; cl00919 1156913002767 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1156913002768 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1156913002769 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1156913002770 ATP binding site [chemical binding]; other site 1156913002771 Mg++ binding site [ion binding]; other site 1156913002772 motif III; other site 1156913002773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913002774 nucleotide binding region [chemical binding]; other site 1156913002775 ATP-binding site [chemical binding]; other site 1156913002776 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1156913002777 dinuclear metal binding motif [ion binding]; other site 1156913002778 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1156913002779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913002780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913002781 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1156913002782 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913002783 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1156913002784 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913002785 active site 1156913002786 hypothetical protein; Provisional; Region: PRK08204 1156913002787 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913002788 active site 1156913002789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913002790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913002791 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913002792 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913002793 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1156913002794 catalytic site [active] 1156913002795 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913002796 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1156913002797 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1156913002798 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1156913002799 ATP binding site [chemical binding]; other site 1156913002800 substrate interface [chemical binding]; other site 1156913002801 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1156913002802 active site residue [active] 1156913002803 TIGR02569 family protein; Region: TIGR02569_actnb 1156913002804 FtsX-like permease family; Region: FtsX; pfam02687 1156913002805 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1156913002806 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913002807 Walker A/P-loop; other site 1156913002808 ATP binding site [chemical binding]; other site 1156913002809 Q-loop/lid; other site 1156913002810 ABC transporter signature motif; other site 1156913002811 Walker B; other site 1156913002812 D-loop; other site 1156913002813 H-loop/switch region; other site 1156913002814 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913002815 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1156913002816 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1156913002817 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1156913002818 [4Fe-4S] binding site [ion binding]; other site 1156913002819 molybdopterin cofactor binding site; other site 1156913002820 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1156913002821 molybdopterin cofactor binding site; other site 1156913002822 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1156913002823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913002824 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1156913002825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913002826 putative substrate translocation pore; other site 1156913002827 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1156913002828 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913002829 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1156913002830 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1156913002831 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1156913002832 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1156913002833 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1156913002834 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1156913002835 active site 1156913002836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913002837 DNA binding site [nucleotide binding] 1156913002838 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1156913002839 Kelch domain; Region: Kelch; smart00612 1156913002840 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1156913002841 Kelch motif; Region: Kelch_6; pfam13964 1156913002842 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1156913002843 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1156913002844 HTH domain; Region: HTH_11; pfam08279 1156913002845 WYL domain; Region: WYL; pfam13280 1156913002846 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1156913002847 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1156913002848 active site 1156913002849 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1156913002850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913002851 ATP binding site [chemical binding]; other site 1156913002852 Mg2+ binding site [ion binding]; other site 1156913002853 G-X-G motif; other site 1156913002854 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1156913002855 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1156913002856 FAD binding pocket [chemical binding]; other site 1156913002857 FAD binding motif [chemical binding]; other site 1156913002858 phosphate binding motif [ion binding]; other site 1156913002859 NAD binding pocket [chemical binding]; other site 1156913002860 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1156913002861 DNA binding site [nucleotide binding] 1156913002862 active site 1156913002863 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1156913002864 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1156913002865 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1156913002866 Part of AAA domain; Region: AAA_19; pfam13245 1156913002867 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1156913002868 Predicted membrane protein [Function unknown]; Region: COG4270 1156913002869 Ion channel; Region: Ion_trans_2; pfam07885 1156913002870 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1156913002871 TrkA-N domain; Region: TrkA_N; pfam02254 1156913002872 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1156913002873 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 1156913002874 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1156913002875 MoxR-like ATPases [General function prediction only]; Region: COG0714 1156913002876 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 1156913002877 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1156913002878 Protein of unknown function DUF58; Region: DUF58; pfam01882 1156913002879 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1156913002880 putative sugar binding sites [chemical binding]; other site 1156913002881 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1156913002882 Q-X-W motif; other site 1156913002883 Integral membrane protein DUF95; Region: DUF95; pfam01944 1156913002884 RDD family; Region: RDD; pfam06271 1156913002885 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1156913002886 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1156913002887 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1156913002888 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1156913002889 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1156913002890 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1156913002891 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1156913002892 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1156913002893 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1156913002894 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1156913002895 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1156913002896 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1156913002897 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1156913002898 putative NADH binding site [chemical binding]; other site 1156913002899 putative active site [active] 1156913002900 nudix motif; other site 1156913002901 putative metal binding site [ion binding]; other site 1156913002902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913002903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913002904 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1156913002905 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913002906 putative DNA binding site [nucleotide binding]; other site 1156913002907 putative Zn2+ binding site [ion binding]; other site 1156913002908 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913002909 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913002910 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913002911 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913002912 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1156913002913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1156913002914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913002915 putative PBP binding loops; other site 1156913002916 dimer interface [polypeptide binding]; other site 1156913002917 ABC-ATPase subunit interface; other site 1156913002918 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913002919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913002920 dimer interface [polypeptide binding]; other site 1156913002921 conserved gate region; other site 1156913002922 putative PBP binding loops; other site 1156913002923 ABC-ATPase subunit interface; other site 1156913002924 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1156913002925 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1156913002926 NAD binding site [chemical binding]; other site 1156913002927 sugar binding site [chemical binding]; other site 1156913002928 divalent metal binding site [ion binding]; other site 1156913002929 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1156913002930 dimer interface [polypeptide binding]; other site 1156913002931 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1156913002932 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1156913002933 putative hydrophobic ligand binding site [chemical binding]; other site 1156913002934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913002935 dimerization interface [polypeptide binding]; other site 1156913002936 putative DNA binding site [nucleotide binding]; other site 1156913002937 putative Zn2+ binding site [ion binding]; other site 1156913002938 GntP family permease; Region: GntP_permease; pfam02447 1156913002939 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1156913002940 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1156913002941 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1156913002942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913002943 DNA-binding site [nucleotide binding]; DNA binding site 1156913002944 FCD domain; Region: FCD; pfam07729 1156913002945 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1156913002946 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 1156913002947 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1156913002948 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1156913002949 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1156913002950 active site 1156913002951 Chorismate mutase type II; Region: CM_2; cl00693 1156913002952 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1156913002953 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1156913002954 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1156913002955 Putative zinc ribbon domain; Region: DUF164; pfam02591 1156913002956 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1156913002957 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1156913002958 RNA/DNA hybrid binding site [nucleotide binding]; other site 1156913002959 active site 1156913002960 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913002961 catalytic core [active] 1156913002962 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1156913002963 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1156913002964 active site 1156913002965 dimer interface [polypeptide binding]; other site 1156913002966 non-prolyl cis peptide bond; other site 1156913002967 insertion regions; other site 1156913002968 AAA ATPase domain; Region: AAA_16; pfam13191 1156913002969 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913002970 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913002971 DNA binding residues [nucleotide binding] 1156913002972 dimerization interface [polypeptide binding]; other site 1156913002973 Putative zinc-finger; Region: zf-HC2; pfam13490 1156913002974 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1156913002975 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913002976 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913002977 DNA binding residues [nucleotide binding] 1156913002978 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1156913002979 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1156913002980 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1156913002981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913002982 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1156913002983 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1156913002984 AAA-like domain; Region: AAA_10; pfam12846 1156913002985 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 1156913002986 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1156913002987 NlpC/P60 family; Region: NLPC_P60; pfam00877 1156913002988 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 1156913002989 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1156913002990 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1156913002991 RNB domain; Region: RNB; pfam00773 1156913002992 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1156913002993 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1156913002994 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1156913002995 intersubunit interface [polypeptide binding]; other site 1156913002996 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913002997 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 1156913002998 NAD(P) binding site [chemical binding]; other site 1156913002999 catalytic residues [active] 1156913003000 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1156913003001 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913003002 inhibitor-cofactor binding pocket; inhibition site 1156913003003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913003004 catalytic residue [active] 1156913003005 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1156913003006 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913003007 Cache domain; Region: Cache_1; pfam02743 1156913003008 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1156913003009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913003010 DNA-binding site [nucleotide binding]; DNA binding site 1156913003011 FCD domain; Region: FCD; pfam07729 1156913003012 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1156913003013 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1156913003014 tetrameric interface [polypeptide binding]; other site 1156913003015 NAD binding site [chemical binding]; other site 1156913003016 catalytic residues [active] 1156913003017 substrate binding site [chemical binding]; other site 1156913003018 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1156913003019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913003020 Walker A/P-loop; other site 1156913003021 ATP binding site [chemical binding]; other site 1156913003022 Q-loop/lid; other site 1156913003023 ABC transporter signature motif; other site 1156913003024 Walker B; other site 1156913003025 D-loop; other site 1156913003026 H-loop/switch region; other site 1156913003027 TOBE domain; Region: TOBE_2; pfam08402 1156913003028 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1156913003029 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1156913003030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913003031 ABC-ATPase subunit interface; other site 1156913003032 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1156913003033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913003034 dimer interface [polypeptide binding]; other site 1156913003035 conserved gate region; other site 1156913003036 ABC-ATPase subunit interface; other site 1156913003037 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1156913003038 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1156913003039 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1156913003040 LGFP repeat; Region: LGFP; pfam08310 1156913003041 LGFP repeat; Region: LGFP; pfam08310 1156913003042 LGFP repeat; Region: LGFP; pfam08310 1156913003043 LGFP repeat; Region: LGFP; pfam08310 1156913003044 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1156913003045 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913003046 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913003047 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1156913003048 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1156913003049 oligomerization interface [polypeptide binding]; other site 1156913003050 active site 1156913003051 metal binding site [ion binding]; metal-binding site 1156913003052 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1156913003053 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1156913003054 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1156913003055 dimer interface [polypeptide binding]; other site 1156913003056 putative anticodon binding site; other site 1156913003057 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1156913003058 motif 1; other site 1156913003059 dimer interface [polypeptide binding]; other site 1156913003060 active site 1156913003061 motif 2; other site 1156913003062 motif 3; other site 1156913003063 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1156913003064 DinB superfamily; Region: DinB_2; pfam12867 1156913003065 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1156913003066 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1156913003067 DNA binding site [nucleotide binding] 1156913003068 active site 1156913003069 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1156913003070 NAD synthetase; Provisional; Region: PRK13981 1156913003071 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1156913003072 multimer interface [polypeptide binding]; other site 1156913003073 active site 1156913003074 catalytic triad [active] 1156913003075 protein interface 1 [polypeptide binding]; other site 1156913003076 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1156913003077 homodimer interface [polypeptide binding]; other site 1156913003078 NAD binding pocket [chemical binding]; other site 1156913003079 ATP binding pocket [chemical binding]; other site 1156913003080 Mg binding site [ion binding]; other site 1156913003081 active-site loop [active] 1156913003082 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1156913003083 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1156913003084 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913003085 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1156913003086 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913003087 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1156913003088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913003089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913003090 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1156913003091 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1156913003092 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1156913003093 amidase; Provisional; Region: PRK08137 1156913003094 Amidase; Region: Amidase; pfam01425 1156913003095 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913003096 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1156913003097 putative DNA binding site [nucleotide binding]; other site 1156913003098 putative Zn2+ binding site [ion binding]; other site 1156913003099 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913003100 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1156913003101 active site residue [active] 1156913003102 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1156913003103 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1156913003104 catalytic triad [active] 1156913003105 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1156913003106 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1156913003107 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1156913003108 metal binding triad; other site 1156913003109 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1156913003110 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1156913003111 metal binding triad; other site 1156913003112 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1156913003113 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1156913003114 active site 1156913003115 glutamine synthetase, type I; Region: GlnA; TIGR00653 1156913003116 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1156913003117 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1156913003118 RDD family; Region: RDD; pfam06271 1156913003119 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1156913003120 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1156913003121 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1156913003122 Part of AAA domain; Region: AAA_19; pfam13245 1156913003123 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1156913003124 Family description; Region: UvrD_C_2; pfam13538 1156913003125 HRDC domain; Region: HRDC; pfam00570 1156913003126 Transcription factor WhiB; Region: Whib; pfam02467 1156913003127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913003128 S-adenosylmethionine binding site [chemical binding]; other site 1156913003129 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1156913003130 ABC1 family; Region: ABC1; pfam03109 1156913003131 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1156913003132 active site 1156913003133 ATP binding site [chemical binding]; other site 1156913003134 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1156913003135 ATP binding site [chemical binding]; other site 1156913003136 Protein of unknown function DUF45; Region: DUF45; cl00636 1156913003137 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1156913003138 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1156913003139 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1156913003140 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1156913003141 hypothetical protein; Validated; Region: PRK00068 1156913003142 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1156913003143 hypothetical protein; Provisional; Region: PRK08244 1156913003144 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913003145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913003146 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913003147 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1156913003148 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1156913003149 RF-1 domain; Region: RF-1; pfam00472 1156913003150 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1156913003151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913003152 Walker A/P-loop; other site 1156913003153 ATP binding site [chemical binding]; other site 1156913003154 Q-loop/lid; other site 1156913003155 ABC transporter signature motif; other site 1156913003156 Walker B; other site 1156913003157 D-loop; other site 1156913003158 H-loop/switch region; other site 1156913003159 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1156913003160 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1156913003161 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1156913003162 SmpB-tmRNA interface; other site 1156913003163 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1156913003164 active site 1156913003165 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1156913003166 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913003167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913003168 active site 1156913003169 phosphorylation site [posttranslational modification] 1156913003170 intermolecular recognition site; other site 1156913003171 dimerization interface [polypeptide binding]; other site 1156913003172 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913003173 DNA binding residues [nucleotide binding] 1156913003174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913003175 Putative sensor; Region: Sensor; pfam13796 1156913003176 Histidine kinase; Region: HisKA_3; pfam07730 1156913003177 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913003178 Putative sensor; Region: Sensor; pfam13796 1156913003179 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 1156913003180 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 1156913003181 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913003182 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1156913003183 catalytic site [active] 1156913003184 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913003185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913003186 putative DNA binding site [nucleotide binding]; other site 1156913003187 putative Zn2+ binding site [ion binding]; other site 1156913003188 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913003189 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1156913003190 active sites [active] 1156913003191 tetramer interface [polypeptide binding]; other site 1156913003192 urocanate hydratase; Provisional; Region: PRK05414 1156913003193 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1156913003194 allantoate amidohydrolase; Reviewed; Region: PRK09290 1156913003195 active site 1156913003196 metal binding site [ion binding]; metal-binding site 1156913003197 dimer interface [polypeptide binding]; other site 1156913003198 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1156913003199 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913003200 active site 1156913003201 imidazolonepropionase; Provisional; Region: PRK14085 1156913003202 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913003203 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1156913003204 active site 1156913003205 Histidine kinase; Region: HisKA_3; pfam07730 1156913003206 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913003207 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913003208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913003209 active site 1156913003210 phosphorylation site [posttranslational modification] 1156913003211 intermolecular recognition site; other site 1156913003212 dimerization interface [polypeptide binding]; other site 1156913003213 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913003214 DNA binding residues [nucleotide binding] 1156913003215 dimerization interface [polypeptide binding]; other site 1156913003216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913003217 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1156913003218 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1156913003219 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913003220 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1156913003221 Walker A/P-loop; other site 1156913003222 ATP binding site [chemical binding]; other site 1156913003223 Q-loop/lid; other site 1156913003224 ABC transporter signature motif; other site 1156913003225 Walker B; other site 1156913003226 D-loop; other site 1156913003227 H-loop/switch region; other site 1156913003228 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1156913003229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913003230 ATP binding site [chemical binding]; other site 1156913003231 putative Mg++ binding site [ion binding]; other site 1156913003232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913003233 nucleotide binding region [chemical binding]; other site 1156913003234 ATP-binding site [chemical binding]; other site 1156913003235 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1156913003236 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1156913003237 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913003238 substrate binding pocket [chemical binding]; other site 1156913003239 membrane-bound complex binding site; other site 1156913003240 hinge residues; other site 1156913003241 Thioredoxin; Region: Thioredoxin_4; cl17273 1156913003242 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1156913003243 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913003244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913003245 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1156913003246 dimerization interface [polypeptide binding]; other site 1156913003247 substrate binding pocket [chemical binding]; other site 1156913003248 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1156913003249 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1156913003250 lipid-transfer protein; Provisional; Region: PRK08256 1156913003251 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1156913003252 active site 1156913003253 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1156913003254 hydrophobic ligand binding site; other site 1156913003255 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1156913003256 active site 1156913003257 catalytic site [active] 1156913003258 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1156913003259 active site 2 [active] 1156913003260 active site 1 [active] 1156913003261 short chain dehydrogenase; Provisional; Region: PRK07791 1156913003262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913003263 NAD(P) binding site [chemical binding]; other site 1156913003264 active site 1156913003265 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913003266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913003267 active site 1156913003268 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1156913003269 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1156913003270 CAP-like domain; other site 1156913003271 active site 1156913003272 primary dimer interface [polypeptide binding]; other site 1156913003273 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1156913003274 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1156913003275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913003276 ATP binding site [chemical binding]; other site 1156913003277 Mg2+ binding site [ion binding]; other site 1156913003278 G-X-G motif; other site 1156913003279 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1156913003280 anchoring element; other site 1156913003281 dimer interface [polypeptide binding]; other site 1156913003282 ATP binding site [chemical binding]; other site 1156913003283 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1156913003284 active site 1156913003285 metal binding site [ion binding]; metal-binding site 1156913003286 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1156913003287 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 1156913003288 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1156913003289 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913003290 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913003291 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1156913003292 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1156913003293 YCII-related domain; Region: YCII; cl00999 1156913003294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913003295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913003296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913003297 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913003298 active site 1156913003299 catalytic tetrad [active] 1156913003300 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913003301 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1156913003302 Walker A/P-loop; other site 1156913003303 ATP binding site [chemical binding]; other site 1156913003304 Q-loop/lid; other site 1156913003305 ABC transporter signature motif; other site 1156913003306 Walker B; other site 1156913003307 D-loop; other site 1156913003308 H-loop/switch region; other site 1156913003309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1156913003310 binding surface 1156913003311 TPR motif; other site 1156913003312 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913003313 CHAT domain; Region: CHAT; pfam12770 1156913003314 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1156913003315 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 1156913003316 nucleotide binding site [chemical binding]; other site 1156913003317 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1156913003318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913003319 AAA domain; Region: AAA_33; pfam13671 1156913003320 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1156913003321 active site 1156913003322 PAS fold; Region: PAS; pfam00989 1156913003323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1156913003324 putative active site [active] 1156913003325 heme pocket [chemical binding]; other site 1156913003326 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1156913003327 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1156913003328 putative active site [active] 1156913003329 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1156913003330 putative active site [active] 1156913003331 heme pocket [chemical binding]; other site 1156913003332 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913003333 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913003334 metal binding site [ion binding]; metal-binding site 1156913003335 active site 1156913003336 I-site; other site 1156913003337 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1156913003338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913003339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913003340 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1156913003341 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1156913003342 active site 1 [active] 1156913003343 dimer interface [polypeptide binding]; other site 1156913003344 hexamer interface [polypeptide binding]; other site 1156913003345 active site 2 [active] 1156913003346 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1156913003347 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1156913003348 putative NAD(P) binding site [chemical binding]; other site 1156913003349 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1156913003350 active site 1156913003351 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1156913003352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913003353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1156913003354 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1156913003355 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1156913003356 dimerization interface [polypeptide binding]; other site 1156913003357 active site 1156913003358 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1156913003359 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1156913003360 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1156913003361 active site 1156913003362 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1156913003363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913003364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1156913003365 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1156913003366 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1156913003367 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 1156913003368 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913003369 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1156913003370 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1156913003371 G1 box; other site 1156913003372 putative GEF interaction site [polypeptide binding]; other site 1156913003373 GTP/Mg2+ binding site [chemical binding]; other site 1156913003374 Switch I region; other site 1156913003375 G2 box; other site 1156913003376 G3 box; other site 1156913003377 Switch II region; other site 1156913003378 G4 box; other site 1156913003379 G5 box; other site 1156913003380 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1156913003381 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1156913003382 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1156913003383 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1156913003384 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1156913003385 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913003386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913003387 dimer interface [polypeptide binding]; other site 1156913003388 conserved gate region; other site 1156913003389 putative PBP binding loops; other site 1156913003390 ABC-ATPase subunit interface; other site 1156913003391 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1156913003392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913003393 putative PBP binding loops; other site 1156913003394 ABC-ATPase subunit interface; other site 1156913003395 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913003396 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913003397 DoxX-like family; Region: DoxX_2; pfam13564 1156913003398 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1156913003399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913003400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913003401 WHG domain; Region: WHG; pfam13305 1156913003402 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1156913003403 GAF domain; Region: GAF; pfam01590 1156913003404 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1156913003405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1156913003406 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1156913003407 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1156913003408 ArsC family; Region: ArsC; pfam03960 1156913003409 catalytic residues [active] 1156913003410 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913003411 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913003412 putative DNA binding site [nucleotide binding]; other site 1156913003413 putative Zn2+ binding site [ion binding]; other site 1156913003414 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1156913003415 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913003416 HTH domain; Region: HTH_11; pfam08279 1156913003417 Predicted transcriptional regulator [Transcription]; Region: COG2378 1156913003418 WYL domain; Region: WYL; pfam13280 1156913003419 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1156913003420 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913003421 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1156913003422 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1156913003423 putative active site [active] 1156913003424 putative metal binding site [ion binding]; other site 1156913003425 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913003426 heat shock protein 90; Provisional; Region: PRK05218 1156913003427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913003428 ATP binding site [chemical binding]; other site 1156913003429 Mg2+ binding site [ion binding]; other site 1156913003430 G-X-G motif; other site 1156913003431 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1156913003432 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1156913003433 ABC-ATPase subunit interface; other site 1156913003434 dimer interface [polypeptide binding]; other site 1156913003435 putative PBP binding regions; other site 1156913003436 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1156913003437 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913003438 ABC-ATPase subunit interface; other site 1156913003439 dimer interface [polypeptide binding]; other site 1156913003440 putative PBP binding regions; other site 1156913003441 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1156913003442 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1156913003443 siderophore binding site; other site 1156913003444 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1156913003445 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1156913003446 Walker A/P-loop; other site 1156913003447 ATP binding site [chemical binding]; other site 1156913003448 Q-loop/lid; other site 1156913003449 ABC transporter signature motif; other site 1156913003450 Walker B; other site 1156913003451 D-loop; other site 1156913003452 H-loop/switch region; other site 1156913003453 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1156913003454 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913003455 ABC-ATPase subunit interface; other site 1156913003456 dimer interface [polypeptide binding]; other site 1156913003457 putative PBP binding regions; other site 1156913003458 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1156913003459 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1156913003460 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1156913003461 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1156913003462 metal binding site [ion binding]; metal-binding site 1156913003463 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1156913003464 4Fe-4S binding domain; Region: Fer4; pfam00037 1156913003465 Cysteine-rich domain; Region: CCG; pfam02754 1156913003466 Cysteine-rich domain; Region: CCG; pfam02754 1156913003467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1156913003468 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1156913003469 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1156913003470 ATPase involved in DNA repair; Region: DUF3686; pfam12458 1156913003471 AAA domain; Region: AAA_22; pfam13401 1156913003472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913003473 Walker A motif; other site 1156913003474 ATP binding site [chemical binding]; other site 1156913003475 Walker B motif; other site 1156913003476 arginine finger; other site 1156913003477 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913003478 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913003479 active site 1156913003480 Helix-turn-helix domain; Region: HTH_38; pfam13936 1156913003481 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 1156913003482 putative DNA binding site [nucleotide binding]; other site 1156913003483 putative Zn2+ binding site [ion binding]; other site 1156913003484 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913003485 Cytochrome P450; Region: p450; cl12078 1156913003486 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1156913003487 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1156913003488 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 1156913003489 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1156913003490 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1156913003491 structural tetrad; other site 1156913003492 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1156913003493 metal ion-dependent adhesion site (MIDAS); other site 1156913003494 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1156913003495 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1156913003496 ligand binding site [chemical binding]; other site 1156913003497 flexible hinge region; other site 1156913003498 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1156913003499 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1156913003500 metal binding site [ion binding]; metal-binding site 1156913003501 nucleotidyl binding site; other site 1156913003502 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1156913003503 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1156913003504 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1156913003505 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1156913003506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1156913003507 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1156913003508 PAS domain; Region: PAS; smart00091 1156913003509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913003510 ATP binding site [chemical binding]; other site 1156913003511 Mg2+ binding site [ion binding]; other site 1156913003512 G-X-G motif; other site 1156913003513 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1156913003514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913003515 active site 1156913003516 phosphorylation site [posttranslational modification] 1156913003517 intermolecular recognition site; other site 1156913003518 dimerization interface [polypeptide binding]; other site 1156913003519 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1156913003520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913003521 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913003522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913003523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913003524 putative substrate translocation pore; other site 1156913003525 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913003526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1156913003527 putative Zn2+ binding site [ion binding]; other site 1156913003528 putative DNA binding site [nucleotide binding]; other site 1156913003529 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913003530 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1156913003531 nucleotide binding site [chemical binding]; other site 1156913003532 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913003533 MarR family; Region: MarR_2; pfam12802 1156913003534 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913003535 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913003536 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1156913003537 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1156913003538 Walker A/P-loop; other site 1156913003539 ATP binding site [chemical binding]; other site 1156913003540 Q-loop/lid; other site 1156913003541 ABC transporter signature motif; other site 1156913003542 Walker B; other site 1156913003543 D-loop; other site 1156913003544 H-loop/switch region; other site 1156913003545 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1156913003546 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913003547 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913003548 TM-ABC transporter signature motif; other site 1156913003549 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1156913003550 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1156913003551 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1156913003552 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913003553 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1156913003554 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 1156913003555 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1156913003556 UbiA prenyltransferase family; Region: UbiA; pfam01040 1156913003557 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1156913003558 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 1156913003559 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1156913003560 TatD related DNase; Region: TatD_DNase; pfam01026 1156913003561 active site 1156913003562 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1156913003563 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1156913003564 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1156913003565 Trehalose utilisation; Region: ThuA; pfam06283 1156913003566 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1156913003567 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1156913003568 FOG: PKD repeat [General function prediction only]; Region: COG3291 1156913003569 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1156913003570 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1156913003571 metal binding site [ion binding]; metal-binding site 1156913003572 ligand binding site [chemical binding]; other site 1156913003573 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1156913003574 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1156913003575 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1156913003576 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1156913003577 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1156913003578 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1156913003579 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913003580 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1156913003581 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1156913003582 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1156913003583 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1156913003584 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1156913003585 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1156913003586 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1156913003587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913003588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913003589 DNA binding residues [nucleotide binding] 1156913003590 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1156913003591 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1156913003592 BCCT family transporter; Region: BCCT; pfam02028 1156913003593 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1156913003594 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913003595 conserved cys residue [active] 1156913003596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913003597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913003598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913003599 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1156913003600 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1156913003601 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1156913003602 potential catalytic triad [active] 1156913003603 conserved cys residue [active] 1156913003604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913003605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913003606 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913003607 hypothetical protein; Provisional; Region: PRK06847 1156913003608 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913003609 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913003610 active site 1156913003611 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1156913003612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913003613 Coenzyme A binding pocket [chemical binding]; other site 1156913003614 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913003615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913003616 NAD(P) binding site [chemical binding]; other site 1156913003617 active site 1156913003618 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913003619 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913003620 Walker A/P-loop; other site 1156913003621 ATP binding site [chemical binding]; other site 1156913003622 Q-loop/lid; other site 1156913003623 ABC transporter signature motif; other site 1156913003624 Walker B; other site 1156913003625 D-loop; other site 1156913003626 H-loop/switch region; other site 1156913003627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913003628 DNA-binding site [nucleotide binding]; DNA binding site 1156913003629 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1156913003630 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1156913003631 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913003632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913003633 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 1156913003634 active site 1156913003635 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1156913003636 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1156913003637 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1156913003638 SpoOM protein; Region: Spo0M; pfam07070 1156913003639 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913003640 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1156913003641 Flavin binding site [chemical binding]; other site 1156913003642 MarR family; Region: MarR_2; cl17246 1156913003643 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913003644 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1156913003645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913003646 putative substrate translocation pore; other site 1156913003647 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1156913003648 hypothetical protein; Provisional; Region: PRK01346 1156913003649 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913003650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913003651 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1156913003652 Walker A/P-loop; other site 1156913003653 ATP binding site [chemical binding]; other site 1156913003654 Q-loop/lid; other site 1156913003655 ABC transporter signature motif; other site 1156913003656 Walker B; other site 1156913003657 D-loop; other site 1156913003658 H-loop/switch region; other site 1156913003659 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913003660 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913003661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913003662 Walker A/P-loop; other site 1156913003663 ATP binding site [chemical binding]; other site 1156913003664 Q-loop/lid; other site 1156913003665 ABC transporter signature motif; other site 1156913003666 Walker B; other site 1156913003667 D-loop; other site 1156913003668 H-loop/switch region; other site 1156913003669 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1156913003670 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1156913003671 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913003672 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913003673 cleavage site 1156913003674 active site 1156913003675 substrate binding sites [chemical binding]; other site 1156913003676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913003677 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 1156913003678 Walker A motif; other site 1156913003679 ATP binding site [chemical binding]; other site 1156913003680 Walker B motif; other site 1156913003681 NB-ARC domain; Region: NB-ARC; pfam00931 1156913003682 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913003683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913003684 binding surface 1156913003685 TPR motif; other site 1156913003686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913003687 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913003688 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913003689 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1156913003690 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1156913003691 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1156913003692 HEXXH motif domain; Region: mod_HExxH; TIGR04267 1156913003693 TPR repeat; Region: TPR_11; pfam13414 1156913003694 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1156913003695 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1156913003696 ligand binding site [chemical binding]; other site 1156913003697 flexible hinge region; other site 1156913003698 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1156913003699 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1156913003700 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1156913003701 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1156913003702 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1156913003703 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913003704 sugar binding site [chemical binding]; other site 1156913003705 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913003706 MarR family; Region: MarR; pfam01047 1156913003707 EamA-like transporter family; Region: EamA; pfam00892 1156913003708 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913003709 Cytochrome P450; Region: p450; cl12078 1156913003710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913003711 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1156913003712 Walker A/P-loop; other site 1156913003713 ATP binding site [chemical binding]; other site 1156913003714 Q-loop/lid; other site 1156913003715 ABC transporter signature motif; other site 1156913003716 Walker B; other site 1156913003717 D-loop; other site 1156913003718 H-loop/switch region; other site 1156913003719 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1156913003720 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1156913003721 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1156913003722 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913003723 DNA binding site [nucleotide binding] 1156913003724 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913003725 Predicted ATPase [General function prediction only]; Region: COG3903 1156913003726 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1156913003727 substrate binding site [chemical binding]; other site 1156913003728 Helix-turn-helix domain; Region: HTH_38; pfam13936 1156913003729 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913003730 putative Zn2+ binding site [ion binding]; other site 1156913003731 putative DNA binding site [nucleotide binding]; other site 1156913003732 short chain dehydrogenase; Validated; Region: PRK06182 1156913003733 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1156913003734 NADP binding site [chemical binding]; other site 1156913003735 active site 1156913003736 steroid binding site; other site 1156913003737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913003738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913003739 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1156913003740 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1156913003741 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1156913003742 FMN-binding pocket [chemical binding]; other site 1156913003743 flavin binding motif; other site 1156913003744 phosphate binding motif [ion binding]; other site 1156913003745 beta-alpha-beta structure motif; other site 1156913003746 NAD binding pocket [chemical binding]; other site 1156913003747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913003748 catalytic loop [active] 1156913003749 iron binding site [ion binding]; other site 1156913003750 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1156913003751 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1156913003752 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1156913003753 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1156913003754 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1156913003755 putative sugar binding sites [chemical binding]; other site 1156913003756 Q-X-W motif; other site 1156913003757 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1156913003758 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1156913003759 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913003760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913003761 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1156913003762 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1156913003763 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913003764 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913003765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913003766 DNA binding residues [nucleotide binding] 1156913003767 dimerization interface [polypeptide binding]; other site 1156913003768 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 1156913003769 AAA domain; Region: AAA_22; pfam13401 1156913003770 Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399 1156913003771 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913003772 DNA binding residues [nucleotide binding] 1156913003773 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1156913003774 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1156913003775 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913003776 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913003777 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1156913003778 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 1156913003779 NAD binding site [chemical binding]; other site 1156913003780 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 1156913003781 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1156913003782 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1156913003783 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1156913003784 ParB-like nuclease domain; Region: ParB; smart00470 1156913003785 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1156913003786 prephenate dehydrogenase; Validated; Region: PRK08507 1156913003787 Prephenate dehydrogenase; Region: PDH; pfam02153 1156913003788 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913003789 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913003790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913003791 Walker A/P-loop; other site 1156913003792 ATP binding site [chemical binding]; other site 1156913003793 Q-loop/lid; other site 1156913003794 ABC transporter signature motif; other site 1156913003795 Walker B; other site 1156913003796 D-loop; other site 1156913003797 H-loop/switch region; other site 1156913003798 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913003799 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913003800 acyl-activating enzyme (AAE) consensus motif; other site 1156913003801 AMP binding site [chemical binding]; other site 1156913003802 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913003803 Condensation domain; Region: Condensation; pfam00668 1156913003804 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913003805 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913003806 acyl-activating enzyme (AAE) consensus motif; other site 1156913003807 AMP binding site [chemical binding]; other site 1156913003808 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913003809 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913003810 Condensation domain; Region: Condensation; pfam00668 1156913003811 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913003812 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913003813 acyl-activating enzyme (AAE) consensus motif; other site 1156913003814 AMP binding site [chemical binding]; other site 1156913003815 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913003816 Condensation domain; Region: Condensation; pfam00668 1156913003817 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913003818 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913003819 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913003820 acyl-activating enzyme (AAE) consensus motif; other site 1156913003821 AMP binding site [chemical binding]; other site 1156913003822 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913003823 Condensation domain; Region: Condensation; cl19241 1156913003824 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913003825 Condensation domain; Region: Condensation; pfam00668 1156913003826 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913003827 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913003828 acyl-activating enzyme (AAE) consensus motif; other site 1156913003829 AMP binding site [chemical binding]; other site 1156913003830 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913003831 Condensation domain; Region: Condensation; cl19241 1156913003832 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913003833 Condensation domain; Region: Condensation; pfam00668 1156913003834 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913003835 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913003836 acyl-activating enzyme (AAE) consensus motif; other site 1156913003837 AMP binding site [chemical binding]; other site 1156913003838 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913003839 Condensation domain; Region: Condensation; pfam00668 1156913003840 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913003841 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913003842 acyl-activating enzyme (AAE) consensus motif; other site 1156913003843 AMP binding site [chemical binding]; other site 1156913003844 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913003845 Condensation domain; Region: Condensation; cl19241 1156913003846 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913003847 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913003848 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1156913003849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1156913003850 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913003851 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913003852 Cytochrome P450; Region: p450; cl12078 1156913003853 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913003854 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1156913003855 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913003856 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913003857 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1156913003858 homodimer interface [polypeptide binding]; other site 1156913003859 active site 1156913003860 TDP-binding site; other site 1156913003861 acceptor substrate-binding pocket; other site 1156913003862 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1156913003863 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913003864 homodimer interface [polypeptide binding]; other site 1156913003865 active site 1156913003866 TDP-binding site; other site 1156913003867 acceptor substrate-binding pocket; other site 1156913003868 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1156913003869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913003870 S-adenosylmethionine binding site [chemical binding]; other site 1156913003871 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1156913003872 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1156913003873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913003874 S-adenosylmethionine binding site [chemical binding]; other site 1156913003875 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1156913003876 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913003877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913003878 homodimer interface [polypeptide binding]; other site 1156913003879 catalytic residue [active] 1156913003880 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913003881 Putative lysophospholipase; Region: Hydrolase_4; cl19140 1156913003882 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913003883 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913003884 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913003885 acyl-activating enzyme (AAE) consensus motif; other site 1156913003886 AMP binding site [chemical binding]; other site 1156913003887 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913003888 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913003889 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1156913003890 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1156913003891 dimer interface [polypeptide binding]; other site 1156913003892 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1156913003893 active site 1156913003894 Fe binding site [ion binding]; other site 1156913003895 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1156913003896 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1156913003897 active site 1156913003898 substrate binding site [chemical binding]; other site 1156913003899 FMN binding site [chemical binding]; other site 1156913003900 putative catalytic residues [active] 1156913003901 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1156913003902 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 1156913003903 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 1156913003904 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1156913003905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913003906 NAD(P) binding site [chemical binding]; other site 1156913003907 active site 1156913003908 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1156913003909 inhibitor-cofactor binding pocket; inhibition site 1156913003910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913003911 catalytic residue [active] 1156913003912 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1156913003913 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1156913003914 malonyl-CoA binding site [chemical binding]; other site 1156913003915 dimer interface [polypeptide binding]; other site 1156913003916 active site 1156913003917 product binding site; other site 1156913003918 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1156913003919 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1156913003920 substrate binding site [chemical binding]; other site 1156913003921 trimer interface [polypeptide binding]; other site 1156913003922 oxyanion hole (OAH) forming residues; other site 1156913003923 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1156913003924 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913003925 substrate binding site [chemical binding]; other site 1156913003926 oxyanion hole (OAH) forming residues; other site 1156913003927 trimer interface [polypeptide binding]; other site 1156913003928 enoyl-CoA hydratase; Provisional; Region: PRK06494 1156913003929 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913003930 substrate binding site [chemical binding]; other site 1156913003931 oxyanion hole (OAH) forming residues; other site 1156913003932 trimer interface [polypeptide binding]; other site 1156913003933 Tc5 transposase DNA-binding domain; Region: HTH_Tnp_Tc5; cl12115 1156913003934 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1156913003935 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1156913003936 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913003937 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913003938 active site 1156913003939 catalytic tetrad [active] 1156913003940 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913003941 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1156913003942 dimerization interface [polypeptide binding]; other site 1156913003943 DNA binding residues [nucleotide binding] 1156913003944 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1156913003945 NlpC/P60 family; Region: NLPC_P60; cl17555 1156913003946 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913003947 homodimer interface [polypeptide binding]; other site 1156913003948 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1156913003949 active site 1156913003950 TDP-binding site; other site 1156913003951 acceptor substrate-binding pocket; other site 1156913003952 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1156913003953 Peptidase family M23; Region: Peptidase_M23; pfam01551 1156913003954 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1156913003955 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913003956 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1156913003957 Walker A motif; other site 1156913003958 ATP binding site [chemical binding]; other site 1156913003959 Walker B motif; other site 1156913003960 arginine finger; other site 1156913003961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913003962 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1156913003963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913003964 Walker A motif; other site 1156913003965 Walker A/P-loop; other site 1156913003966 ATP binding site [chemical binding]; other site 1156913003967 ATP binding site [chemical binding]; other site 1156913003968 Walker B motif; other site 1156913003969 arginine finger; other site 1156913003970 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1156913003971 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 1156913003972 NodB motif; other site 1156913003973 putative active site [active] 1156913003974 putative catalytic site [active] 1156913003975 putative Zn binding site [ion binding]; other site 1156913003976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913003977 S-adenosylmethionine binding site [chemical binding]; other site 1156913003978 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1156913003979 metal-binding site [ion binding] 1156913003980 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1156913003981 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1156913003982 putative homodimer interface [polypeptide binding]; other site 1156913003983 putative homotetramer interface [polypeptide binding]; other site 1156913003984 putative allosteric switch controlling residues; other site 1156913003985 putative metal binding site [ion binding]; other site 1156913003986 putative homodimer-homodimer interface [polypeptide binding]; other site 1156913003987 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1156913003988 putative homodimer interface [polypeptide binding]; other site 1156913003989 putative homotetramer interface [polypeptide binding]; other site 1156913003990 putative allosteric switch controlling residues; other site 1156913003991 putative metal binding site [ion binding]; other site 1156913003992 putative homodimer-homodimer interface [polypeptide binding]; other site 1156913003993 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1156913003994 metal-binding site [ion binding] 1156913003995 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1156913003996 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1156913003997 metal-binding site [ion binding] 1156913003998 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1156913003999 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 1156913004000 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1156913004001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913004002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913004003 putative substrate translocation pore; other site 1156913004004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913004005 YCII-related domain; Region: YCII; cl00999 1156913004006 AAA ATPase domain; Region: AAA_16; pfam13191 1156913004007 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913004008 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913004009 DNA binding residues [nucleotide binding] 1156913004010 dimerization interface [polypeptide binding]; other site 1156913004011 PAS domain S-box; Region: sensory_box; TIGR00229 1156913004012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1156913004013 putative active site [active] 1156913004014 heme pocket [chemical binding]; other site 1156913004015 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913004016 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913004017 metal binding site [ion binding]; metal-binding site 1156913004018 active site 1156913004019 I-site; other site 1156913004020 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1156913004021 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1156913004022 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913004023 Cytochrome P450; Region: p450; cl12078 1156913004024 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1156913004025 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1156913004026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913004027 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1156913004028 DNA binding residues [nucleotide binding] 1156913004029 AAA ATPase domain; Region: AAA_16; pfam13191 1156913004030 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1156913004031 WD domain, G-beta repeat; Region: WD40; pfam00400 1156913004032 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1156913004033 structural tetrad; other site 1156913004034 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1156913004035 structural tetrad; other site 1156913004036 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1156913004037 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1156913004038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913004039 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1156913004040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913004041 S-adenosylmethionine binding site [chemical binding]; other site 1156913004042 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1156913004043 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1156913004044 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1156913004045 active site lid residues [active] 1156913004046 substrate binding pocket [chemical binding]; other site 1156913004047 catalytic residues [active] 1156913004048 substrate-Mg2+ binding site; other site 1156913004049 aspartate-rich region 1; other site 1156913004050 aspartate-rich region 2; other site 1156913004051 phytoene desaturase; Region: crtI_fam; TIGR02734 1156913004052 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1156913004053 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1156913004054 substrate binding pocket [chemical binding]; other site 1156913004055 chain length determination region; other site 1156913004056 substrate-Mg2+ binding site; other site 1156913004057 catalytic residues [active] 1156913004058 aspartate-rich region 1; other site 1156913004059 active site lid residues [active] 1156913004060 aspartate-rich region 2; other site 1156913004061 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1156913004062 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1156913004063 DNA binding residues [nucleotide binding] 1156913004064 B12 binding domain; Region: B12-binding_2; cl03653 1156913004065 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1156913004066 B12 binding site [chemical binding]; other site 1156913004067 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1156913004068 iron-sulfur cluster [ion binding]; other site 1156913004069 [2Fe-2S] cluster binding site [ion binding]; other site 1156913004070 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913004071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913004072 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913004073 Cytochrome P450; Region: p450; cl12078 1156913004074 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913004075 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1156913004076 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1156913004077 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1156913004078 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1156913004079 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913004080 acyl-activating enzyme (AAE) consensus motif; other site 1156913004081 AMP binding site [chemical binding]; other site 1156913004082 active site 1156913004083 CoA binding site [chemical binding]; other site 1156913004084 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1156913004085 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1156913004086 FMN-binding pocket [chemical binding]; other site 1156913004087 flavin binding motif; other site 1156913004088 phosphate binding motif [ion binding]; other site 1156913004089 beta-alpha-beta structure motif; other site 1156913004090 NAD binding pocket [chemical binding]; other site 1156913004091 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913004092 catalytic loop [active] 1156913004093 iron binding site [ion binding]; other site 1156913004094 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1156913004095 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1156913004096 putative sugar binding sites [chemical binding]; other site 1156913004097 Q-X-W motif; other site 1156913004098 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1156913004099 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1156913004100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913004101 active site 1156913004102 phosphorylation site [posttranslational modification] 1156913004103 intermolecular recognition site; other site 1156913004104 dimerization interface [polypeptide binding]; other site 1156913004105 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1156913004106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913004107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913004108 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1156913004109 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1156913004110 ligand binding site [chemical binding]; other site 1156913004111 flexible hinge region; other site 1156913004112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913004113 ATP binding site [chemical binding]; other site 1156913004114 Mg2+ binding site [ion binding]; other site 1156913004115 G-X-G motif; other site 1156913004116 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1156913004117 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1156913004118 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1156913004119 metal ion-dependent adhesion site (MIDAS); other site 1156913004120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913004121 S-adenosylmethionine binding site [chemical binding]; other site 1156913004122 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913004123 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1156913004124 Peptidase family M28; Region: Peptidase_M28; pfam04389 1156913004125 metal binding site [ion binding]; metal-binding site 1156913004126 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913004127 Interdomain contacts; other site 1156913004128 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913004129 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913004130 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1156913004131 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913004132 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913004133 DNA binding residues [nucleotide binding] 1156913004134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913004135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913004136 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913004137 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1156913004138 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1156913004139 active site 1156913004140 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1156913004141 active site 1156913004142 metal binding site [ion binding]; metal-binding site 1156913004143 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 1156913004144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913004145 NAD(P) binding site [chemical binding]; other site 1156913004146 active site 1156913004147 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913004148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913004149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913004150 DNA binding residues [nucleotide binding] 1156913004151 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913004152 nucleotide binding site [chemical binding]; other site 1156913004153 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1156913004154 Dynamin family; Region: Dynamin_N; pfam00350 1156913004155 G1 box; other site 1156913004156 GTP/Mg2+ binding site [chemical binding]; other site 1156913004157 G2 box; other site 1156913004158 Switch I region; other site 1156913004159 G3 box; other site 1156913004160 Switch II region; other site 1156913004161 G4 box; other site 1156913004162 G5 box; other site 1156913004163 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1156913004164 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1156913004165 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913004166 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1156913004167 acyl-activating enzyme (AAE) consensus motif; other site 1156913004168 acyl-activating enzyme (AAE) consensus motif; other site 1156913004169 putative AMP binding site [chemical binding]; other site 1156913004170 putative active site [active] 1156913004171 putative CoA binding site [chemical binding]; other site 1156913004172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913004173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913004174 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1156913004175 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1156913004176 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1156913004177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913004178 substrate binding pocket [chemical binding]; other site 1156913004179 membrane-bound complex binding site; other site 1156913004180 hinge residues; other site 1156913004181 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1156913004182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913004183 dimer interface [polypeptide binding]; other site 1156913004184 conserved gate region; other site 1156913004185 putative PBP binding loops; other site 1156913004186 ABC-ATPase subunit interface; other site 1156913004187 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1156913004188 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1156913004189 Walker A/P-loop; other site 1156913004190 ATP binding site [chemical binding]; other site 1156913004191 Q-loop/lid; other site 1156913004192 ABC transporter signature motif; other site 1156913004193 Walker B; other site 1156913004194 D-loop; other site 1156913004195 H-loop/switch region; other site 1156913004196 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1156913004197 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913004198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913004199 catalytic residue [active] 1156913004200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1156913004201 YheO-like PAS domain; Region: PAS_6; pfam08348 1156913004202 HTH domain; Region: HTH_22; pfam13309 1156913004203 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913004204 active site 1156913004205 TDP-binding site; other site 1156913004206 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1156913004207 acceptor substrate-binding pocket; other site 1156913004208 homodimer interface [polypeptide binding]; other site 1156913004209 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913004210 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1156913004211 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913004212 Walker A/P-loop; other site 1156913004213 ATP binding site [chemical binding]; other site 1156913004214 Q-loop/lid; other site 1156913004215 ABC transporter signature motif; other site 1156913004216 Walker B; other site 1156913004217 D-loop; other site 1156913004218 H-loop/switch region; other site 1156913004219 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913004220 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1156913004221 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1156913004222 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913004223 DNA polymerase IV; Provisional; Region: PRK03348 1156913004224 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1156913004225 active site 1156913004226 DNA binding site [nucleotide binding] 1156913004227 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1156913004228 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1156913004229 putative active site [active] 1156913004230 putative metal binding site [ion binding]; other site 1156913004231 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1156913004232 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1156913004233 substrate binding pocket [chemical binding]; other site 1156913004234 chain length determination region; other site 1156913004235 substrate-Mg2+ binding site; other site 1156913004236 catalytic residues [active] 1156913004237 aspartate-rich region 1; other site 1156913004238 active site lid residues [active] 1156913004239 aspartate-rich region 2; other site 1156913004240 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 1156913004241 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1156913004242 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 1156913004243 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 1156913004244 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1156913004245 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1156913004246 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913004247 Berberine and berberine like; Region: BBE; pfam08031 1156913004248 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1156913004249 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913004250 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913004251 AAA ATPase domain; Region: AAA_16; pfam13191 1156913004252 NB-ARC domain; Region: NB-ARC; pfam00931 1156913004253 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913004254 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913004255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913004256 binding surface 1156913004257 TPR motif; other site 1156913004258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913004259 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913004260 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1156913004261 PhoD-like phosphatase; Region: PhoD; pfam09423 1156913004262 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1156913004263 putative active site [active] 1156913004264 putative metal binding site [ion binding]; other site 1156913004265 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1156913004266 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913004267 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913004268 putative DNA binding site [nucleotide binding]; other site 1156913004269 dimerization interface [polypeptide binding]; other site 1156913004270 putative Zn2+ binding site [ion binding]; other site 1156913004271 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1156913004272 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1156913004273 dihydropteroate synthase; Region: DHPS; TIGR01496 1156913004274 substrate binding pocket [chemical binding]; other site 1156913004275 dimer interface [polypeptide binding]; other site 1156913004276 inhibitor binding site; inhibition site 1156913004277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913004278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913004279 ATP binding site [chemical binding]; other site 1156913004280 Mg2+ binding site [ion binding]; other site 1156913004281 G-X-G motif; other site 1156913004282 NMT1-like family; Region: NMT1_2; pfam13379 1156913004283 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1156913004284 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1156913004285 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1156913004286 Walker A/P-loop; other site 1156913004287 ATP binding site [chemical binding]; other site 1156913004288 Q-loop/lid; other site 1156913004289 ABC transporter signature motif; other site 1156913004290 Walker B; other site 1156913004291 D-loop; other site 1156913004292 H-loop/switch region; other site 1156913004293 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1156913004294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913004295 dimer interface [polypeptide binding]; other site 1156913004296 conserved gate region; other site 1156913004297 putative PBP binding loops; other site 1156913004298 ABC-ATPase subunit interface; other site 1156913004299 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1156913004300 homodimer interface [polypeptide binding]; other site 1156913004301 putative substrate binding pocket [chemical binding]; other site 1156913004302 diiron center [ion binding]; other site 1156913004303 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1156913004304 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1156913004305 ATP binding site [chemical binding]; other site 1156913004306 Mg++ binding site [ion binding]; other site 1156913004307 motif III; other site 1156913004308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913004309 nucleotide binding region [chemical binding]; other site 1156913004310 ATP-binding site [chemical binding]; other site 1156913004311 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913004312 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913004313 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913004314 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1156913004315 active site 1156913004316 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1156913004317 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1156913004318 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1156913004319 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1156913004320 RNA binding site [nucleotide binding]; other site 1156913004321 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1156913004322 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1156913004323 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1156913004324 putative active site [active] 1156913004325 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1156913004326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913004327 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1156913004328 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1156913004329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1156913004330 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1156913004331 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1156913004332 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913004333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913004334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913004335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913004336 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913004337 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1156913004338 acyl-activating enzyme (AAE) consensus motif; other site 1156913004339 AMP binding site [chemical binding]; other site 1156913004340 active site 1156913004341 CoA binding site [chemical binding]; other site 1156913004342 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1156913004343 CoenzymeA binding site [chemical binding]; other site 1156913004344 subunit interaction site [polypeptide binding]; other site 1156913004345 PHB binding site; other site 1156913004346 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1156913004347 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1156913004348 substrate binding site [chemical binding]; other site 1156913004349 dimer interface [polypeptide binding]; other site 1156913004350 NADP binding site [chemical binding]; other site 1156913004351 catalytic residues [active] 1156913004352 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1156913004353 active site 2 [active] 1156913004354 active site 1 [active] 1156913004355 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1156913004356 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1156913004357 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1156913004358 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1156913004359 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1156913004360 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1156913004361 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1156913004362 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1156913004363 FAD binding pocket [chemical binding]; other site 1156913004364 FAD binding motif [chemical binding]; other site 1156913004365 phosphate binding motif [ion binding]; other site 1156913004366 beta-alpha-beta structure motif; other site 1156913004367 NAD(p) ribose binding residues [chemical binding]; other site 1156913004368 NAD binding pocket [chemical binding]; other site 1156913004369 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1156913004370 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913004371 catalytic loop [active] 1156913004372 iron binding site [ion binding]; other site 1156913004373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913004374 Walker A/P-loop; other site 1156913004375 ATP binding site [chemical binding]; other site 1156913004376 ABC transporter; Region: ABC_tran; pfam00005 1156913004377 Q-loop/lid; other site 1156913004378 ABC transporter signature motif; other site 1156913004379 Walker B; other site 1156913004380 D-loop; other site 1156913004381 H-loop/switch region; other site 1156913004382 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1156913004383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913004384 Walker A/P-loop; other site 1156913004385 ATP binding site [chemical binding]; other site 1156913004386 ABC transporter signature motif; other site 1156913004387 Walker B; other site 1156913004388 D-loop; other site 1156913004389 H-loop/switch region; other site 1156913004390 RibD C-terminal domain; Region: RibD_C; cl17279 1156913004391 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1156913004392 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1156913004393 catalytic motif [active] 1156913004394 Zn binding site [ion binding]; other site 1156913004395 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1156913004396 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1156913004397 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1156913004398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913004399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913004400 active site 1156913004401 phosphorylation site [posttranslational modification] 1156913004402 intermolecular recognition site; other site 1156913004403 dimerization interface [polypeptide binding]; other site 1156913004404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913004405 DNA binding site [nucleotide binding] 1156913004406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913004407 dimerization interface [polypeptide binding]; other site 1156913004408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913004409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913004410 dimer interface [polypeptide binding]; other site 1156913004411 phosphorylation site [posttranslational modification] 1156913004412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913004413 ATP binding site [chemical binding]; other site 1156913004414 G-X-G motif; other site 1156913004415 glycerate kinase; Region: TIGR00045 1156913004416 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1156913004417 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913004418 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913004419 active site 1156913004420 UvrB/uvrC motif; Region: UVR; pfam02151 1156913004421 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913004422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913004423 non-specific DNA binding site [nucleotide binding]; other site 1156913004424 salt bridge; other site 1156913004425 sequence-specific DNA binding site [nucleotide binding]; other site 1156913004426 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1156913004427 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1156913004428 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913004429 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913004430 Walker A/P-loop; other site 1156913004431 ATP binding site [chemical binding]; other site 1156913004432 Q-loop/lid; other site 1156913004433 ABC transporter signature motif; other site 1156913004434 Walker B; other site 1156913004435 D-loop; other site 1156913004436 H-loop/switch region; other site 1156913004437 precorrin-3B synthase; Region: CobG; TIGR02435 1156913004438 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1156913004439 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1156913004440 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1156913004441 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1156913004442 active site 1156913004443 SAM binding site [chemical binding]; other site 1156913004444 homodimer interface [polypeptide binding]; other site 1156913004445 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1156913004446 active site 1156913004447 SAM binding site [chemical binding]; other site 1156913004448 homodimer interface [polypeptide binding]; other site 1156913004449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913004450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913004451 active site 1156913004452 phosphorylation site [posttranslational modification] 1156913004453 intermolecular recognition site; other site 1156913004454 dimerization interface [polypeptide binding]; other site 1156913004455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913004456 DNA binding residues [nucleotide binding] 1156913004457 dimerization interface [polypeptide binding]; other site 1156913004458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913004459 Walker A/P-loop; other site 1156913004460 ATP binding site [chemical binding]; other site 1156913004461 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1156913004462 structural tetrad; other site 1156913004463 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1156913004464 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1156913004465 structural tetrad; other site 1156913004466 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1156913004467 Part of AAA domain; Region: AAA_19; pfam13245 1156913004468 Family description; Region: UvrD_C_2; pfam13538 1156913004469 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1156913004470 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1156913004471 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1156913004472 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1156913004473 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913004474 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1156913004475 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1156913004476 active site 1156913004477 SAM binding site [chemical binding]; other site 1156913004478 homodimer interface [polypeptide binding]; other site 1156913004479 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1156913004480 active site 1156913004481 putative homodimer interface [polypeptide binding]; other site 1156913004482 SAM binding site [chemical binding]; other site 1156913004483 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1156913004484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1156913004485 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1156913004486 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1156913004487 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 1156913004488 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1156913004489 metal ion-dependent adhesion site (MIDAS); other site 1156913004490 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1156913004491 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1156913004492 homodimer interface [polypeptide binding]; other site 1156913004493 Walker A motif; other site 1156913004494 ATP binding site [chemical binding]; other site 1156913004495 hydroxycobalamin binding site [chemical binding]; other site 1156913004496 Walker B motif; other site 1156913004497 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1156913004498 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1156913004499 catalytic triad [active] 1156913004500 hypothetical protein; Provisional; Region: PRK07908 1156913004501 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913004502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913004503 homodimer interface [polypeptide binding]; other site 1156913004504 catalytic residue [active] 1156913004505 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1156913004506 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1156913004507 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1156913004508 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913004509 DNA binding residues [nucleotide binding] 1156913004510 putative dimer interface [polypeptide binding]; other site 1156913004511 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1156913004512 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1156913004513 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1156913004514 putative dimer interface [polypeptide binding]; other site 1156913004515 active site pocket [active] 1156913004516 putative cataytic base [active] 1156913004517 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1156913004518 homotrimer interface [polypeptide binding]; other site 1156913004519 Walker A motif; other site 1156913004520 GTP binding site [chemical binding]; other site 1156913004521 Walker B motif; other site 1156913004522 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1156913004523 cobyric acid synthase; Provisional; Region: PRK00784 1156913004524 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1156913004525 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1156913004526 catalytic triad [active] 1156913004527 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1156913004528 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913004529 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913004530 Walker A/P-loop; other site 1156913004531 ATP binding site [chemical binding]; other site 1156913004532 Q-loop/lid; other site 1156913004533 ABC transporter signature motif; other site 1156913004534 Walker B; other site 1156913004535 D-loop; other site 1156913004536 H-loop/switch region; other site 1156913004537 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913004538 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1156913004539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913004540 Histidine kinase; Region: HisKA_3; pfam07730 1156913004541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913004542 ATP binding site [chemical binding]; other site 1156913004543 Mg2+ binding site [ion binding]; other site 1156913004544 G-X-G motif; other site 1156913004545 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913004546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913004547 active site 1156913004548 phosphorylation site [posttranslational modification] 1156913004549 intermolecular recognition site; other site 1156913004550 dimerization interface [polypeptide binding]; other site 1156913004551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913004552 DNA binding residues [nucleotide binding] 1156913004553 dimerization interface [polypeptide binding]; other site 1156913004554 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913004555 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1156913004556 nucleotide binding site [chemical binding]; other site 1156913004557 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1156913004558 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1156913004559 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1156913004560 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1156913004561 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1156913004562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913004563 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1156913004564 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1156913004565 active site 1156913004566 dimer interface [polypeptide binding]; other site 1156913004567 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1156913004568 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1156913004569 active site 1156913004570 FMN binding site [chemical binding]; other site 1156913004571 substrate binding site [chemical binding]; other site 1156913004572 3Fe-4S cluster binding site [ion binding]; other site 1156913004573 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1156913004574 domain interface; other site 1156913004575 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1156913004576 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1156913004577 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1156913004578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913004579 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913004580 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913004581 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1156913004582 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913004583 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1156913004584 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1156913004585 ligand binding site [chemical binding]; other site 1156913004586 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1156913004587 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1156913004588 TM-ABC transporter signature motif; other site 1156913004589 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1156913004590 TM-ABC transporter signature motif; other site 1156913004591 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1156913004592 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1156913004593 Walker A/P-loop; other site 1156913004594 ATP binding site [chemical binding]; other site 1156913004595 Q-loop/lid; other site 1156913004596 ABC transporter signature motif; other site 1156913004597 Walker B; other site 1156913004598 D-loop; other site 1156913004599 H-loop/switch region; other site 1156913004600 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1156913004601 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1156913004602 Walker A/P-loop; other site 1156913004603 ATP binding site [chemical binding]; other site 1156913004604 Q-loop/lid; other site 1156913004605 ABC transporter signature motif; other site 1156913004606 Walker B; other site 1156913004607 D-loop; other site 1156913004608 H-loop/switch region; other site 1156913004609 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913004610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913004611 active site 1156913004612 phosphorylation site [posttranslational modification] 1156913004613 intermolecular recognition site; other site 1156913004614 dimerization interface [polypeptide binding]; other site 1156913004615 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913004616 DNA binding residues [nucleotide binding] 1156913004617 dimerization interface [polypeptide binding]; other site 1156913004618 GAF domain; Region: GAF; pfam01590 1156913004619 GAF domain; Region: GAF_2; pfam13185 1156913004620 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1156913004621 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913004622 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1156913004623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913004624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913004625 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913004626 Cytochrome P450; Region: p450; cl12078 1156913004627 Phosphotransferase enzyme family; Region: APH; pfam01636 1156913004628 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1156913004629 active site 1156913004630 ATP binding site [chemical binding]; other site 1156913004631 substrate binding site [chemical binding]; other site 1156913004632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913004633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913004634 Cytochrome P450; Region: p450; cl12078 1156913004635 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913004636 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1156913004637 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1156913004638 hypothetical protein; Provisional; Region: PRK01346 1156913004639 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1156913004640 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1156913004641 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1156913004642 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1156913004643 homotrimer interaction site [polypeptide binding]; other site 1156913004644 putative active site [active] 1156913004645 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1156913004646 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1156913004647 Dienelactone hydrolase family; Region: DLH; pfam01738 1156913004648 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1156913004649 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1156913004650 active site 1156913004651 Mn binding site [ion binding]; other site 1156913004652 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1156913004653 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1156913004654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913004655 catalytic residue [active] 1156913004656 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913004657 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913004658 metal binding site [ion binding]; metal-binding site 1156913004659 active site 1156913004660 I-site; other site 1156913004661 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913004662 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1156913004663 VanW like protein; Region: VanW; pfam04294 1156913004664 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1156913004665 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1156913004666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913004667 DNA-binding site [nucleotide binding]; DNA binding site 1156913004668 FCD domain; Region: FCD; pfam07729 1156913004669 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1156913004670 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913004671 active site 1156913004672 metal binding site [ion binding]; metal-binding site 1156913004673 homotetramer interface [polypeptide binding]; other site 1156913004674 hypothetical protein; Provisional; Region: PRK07945 1156913004675 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1156913004676 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1156913004677 active site 1156913004678 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1156913004679 chitosan binding site [chemical binding]; other site 1156913004680 catalytic residues [active] 1156913004681 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913004682 dimerization interface [polypeptide binding]; other site 1156913004683 putative DNA binding site [nucleotide binding]; other site 1156913004684 putative Zn2+ binding site [ion binding]; other site 1156913004685 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1156913004686 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1156913004687 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1156913004688 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1156913004689 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1156913004690 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1156913004691 phosphate binding site [ion binding]; other site 1156913004692 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1156913004693 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913004694 ATP binding site [chemical binding]; other site 1156913004695 putative Mg++ binding site [ion binding]; other site 1156913004696 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913004697 nucleotide binding region [chemical binding]; other site 1156913004698 ATP-binding site [chemical binding]; other site 1156913004699 Helicase associated domain (HA2); Region: HA2; pfam04408 1156913004700 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1156913004701 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1156913004702 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 1156913004703 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 1156913004704 active site 1156913004705 DNA binding site [nucleotide binding] 1156913004706 catalytic site [active] 1156913004707 acyl-CoA synthetase; Validated; Region: PRK07788 1156913004708 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913004709 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1156913004710 acyl-activating enzyme (AAE) consensus motif; other site 1156913004711 putative AMP binding site [chemical binding]; other site 1156913004712 putative active site [active] 1156913004713 putative CoA binding site [chemical binding]; other site 1156913004714 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1156913004715 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1156913004716 calcium binding site 2 [ion binding]; other site 1156913004717 active site 1156913004718 catalytic triad [active] 1156913004719 calcium binding site 1 [ion binding]; other site 1156913004720 short chain dehydrogenase; Provisional; Region: PRK08251 1156913004721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913004722 NAD(P) binding site [chemical binding]; other site 1156913004723 active site 1156913004724 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1156913004725 putative active site [active] 1156913004726 putative substrate binding site [chemical binding]; other site 1156913004727 ATP binding site [chemical binding]; other site 1156913004728 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913004729 catalytic core [active] 1156913004730 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1156913004731 Strictosidine synthase; Region: Str_synth; pfam03088 1156913004732 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1156913004733 Predicted transcriptional regulator [Transcription]; Region: COG2378 1156913004734 HTH domain; Region: HTH_11; pfam08279 1156913004735 WYL domain; Region: WYL; pfam13280 1156913004736 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913004737 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913004738 active site 1156913004739 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1156913004740 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913004741 substrate binding site [chemical binding]; other site 1156913004742 oxyanion hole (OAH) forming residues; other site 1156913004743 trimer interface [polypeptide binding]; other site 1156913004744 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913004745 classical (c) SDRs; Region: SDR_c; cd05233 1156913004746 NAD(P) binding site [chemical binding]; other site 1156913004747 active site 1156913004748 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913004749 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 1156913004750 acyl-activating enzyme (AAE) consensus motif; other site 1156913004751 AMP binding site [chemical binding]; other site 1156913004752 active site 1156913004753 CoA binding site [chemical binding]; other site 1156913004754 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1156913004755 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1156913004756 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1156913004757 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1156913004758 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1156913004759 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913004760 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1156913004761 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1156913004762 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1156913004763 NAD binding site [chemical binding]; other site 1156913004764 Phe binding site; other site 1156913004765 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913004766 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913004767 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913004768 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913004769 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1156913004770 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1156913004771 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913004772 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913004773 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1156913004774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913004775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913004776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913004777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913004778 dimerization interface [polypeptide binding]; other site 1156913004779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913004780 dimer interface [polypeptide binding]; other site 1156913004781 phosphorylation site [posttranslational modification] 1156913004782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913004783 ATP binding site [chemical binding]; other site 1156913004784 Mg2+ binding site [ion binding]; other site 1156913004785 G-X-G motif; other site 1156913004786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913004787 Q-loop/lid; other site 1156913004788 ABC transporter signature motif; other site 1156913004789 Walker B; other site 1156913004790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913004791 Walker A/P-loop; other site 1156913004792 ATP binding site [chemical binding]; other site 1156913004793 Q-loop/lid; other site 1156913004794 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913004795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913004796 active site 1156913004797 phosphorylation site [posttranslational modification] 1156913004798 intermolecular recognition site; other site 1156913004799 dimerization interface [polypeptide binding]; other site 1156913004800 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913004801 DNA binding site [nucleotide binding] 1156913004802 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1156913004803 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1156913004804 active site 1156913004805 catalytic triad [active] 1156913004806 dimer interface [polypeptide binding]; other site 1156913004807 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1156913004808 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1156913004809 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913004810 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913004811 DNA binding site [nucleotide binding] 1156913004812 domain linker motif; other site 1156913004813 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1156913004814 dimerization interface [polypeptide binding]; other site 1156913004815 ligand binding site [chemical binding]; other site 1156913004816 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1156913004817 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913004818 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1156913004819 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1156913004820 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1156913004821 putative acyl-acceptor binding pocket; other site 1156913004822 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1156913004823 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913004824 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1156913004825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913004826 non-specific DNA binding site [nucleotide binding]; other site 1156913004827 salt bridge; other site 1156913004828 sequence-specific DNA binding site [nucleotide binding]; other site 1156913004829 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1156913004830 nudix motif; other site 1156913004831 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1156913004832 pentamer interface [polypeptide binding]; other site 1156913004833 dodecaamer interface [polypeptide binding]; other site 1156913004834 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1156913004835 phosphopeptide binding site; other site 1156913004836 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1156913004837 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1156913004838 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913004839 HTH domain; Region: HTH_11; pfam08279 1156913004840 WYL domain; Region: WYL; pfam13280 1156913004841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913004842 Coenzyme A binding pocket [chemical binding]; other site 1156913004843 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913004844 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1156913004845 putative NAD(P) binding site [chemical binding]; other site 1156913004846 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913004847 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913004848 active site 1156913004849 PBP superfamily domain; Region: PBP_like_2; cl17296 1156913004850 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1156913004851 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1156913004852 Walker A/P-loop; other site 1156913004853 ATP binding site [chemical binding]; other site 1156913004854 Q-loop/lid; other site 1156913004855 ABC transporter signature motif; other site 1156913004856 Walker B; other site 1156913004857 D-loop; other site 1156913004858 H-loop/switch region; other site 1156913004859 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1156913004860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913004861 dimer interface [polypeptide binding]; other site 1156913004862 conserved gate region; other site 1156913004863 putative PBP binding loops; other site 1156913004864 ABC-ATPase subunit interface; other site 1156913004865 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1156913004866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913004867 dimer interface [polypeptide binding]; other site 1156913004868 conserved gate region; other site 1156913004869 putative PBP binding loops; other site 1156913004870 ABC-ATPase subunit interface; other site 1156913004871 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 1156913004872 active site 1156913004873 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1156913004874 putative active site [active] 1156913004875 putative catalytic triad [active] 1156913004876 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1156913004877 PBP superfamily domain; Region: PBP_like_2; cl17296 1156913004878 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1156913004879 classical (c) SDRs; Region: SDR_c; cd05233 1156913004880 NAD(P) binding site [chemical binding]; other site 1156913004881 active site 1156913004882 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1156913004883 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913004884 NAD(P) binding site [chemical binding]; other site 1156913004885 active site 1156913004886 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913004887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913004888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1156913004889 dimerization interface [polypeptide binding]; other site 1156913004890 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1156913004891 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1156913004892 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1156913004893 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 1156913004894 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 1156913004895 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1156913004896 FO synthase; Reviewed; Region: fbiC; PRK09234 1156913004897 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913004898 FeS/SAM binding site; other site 1156913004899 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 1156913004900 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913004901 FeS/SAM binding site; other site 1156913004902 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1156913004903 malonic semialdehyde reductase; Provisional; Region: PRK10538 1156913004904 putative NAD(P) binding site [chemical binding]; other site 1156913004905 homodimer interface [polypeptide binding]; other site 1156913004906 homotetramer interface [polypeptide binding]; other site 1156913004907 active site 1156913004908 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913004909 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913004910 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1156913004911 active site 1156913004912 SAM binding site [chemical binding]; other site 1156913004913 homodimer interface [polypeptide binding]; other site 1156913004914 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1156913004915 metal-binding site [ion binding] 1156913004916 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1156913004917 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1156913004918 metal-binding site [ion binding] 1156913004919 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1156913004920 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1156913004921 putative homodimer interface [polypeptide binding]; other site 1156913004922 putative homotetramer interface [polypeptide binding]; other site 1156913004923 putative allosteric switch controlling residues; other site 1156913004924 putative metal binding site [ion binding]; other site 1156913004925 putative homodimer-homodimer interface [polypeptide binding]; other site 1156913004926 YCII-related domain; Region: YCII; cl00999 1156913004927 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913004928 CopC domain; Region: CopC; pfam04234 1156913004929 Copper resistance protein D; Region: CopD; cl00563 1156913004930 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913004931 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913004932 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913004933 DNA binding site [nucleotide binding] 1156913004934 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913004935 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1156913004936 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1156913004937 YcaO-like family; Region: YcaO; pfam02624 1156913004938 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1156913004939 NADPH bind site [chemical binding]; other site 1156913004940 putative FMN binding site [chemical binding]; other site 1156913004941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913004942 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913004943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913004944 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 1156913004945 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 1156913004946 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 1156913004947 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 1156913004948 Cytochrome P450; Region: p450; cl12078 1156913004949 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1156913004950 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1156913004951 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1156913004952 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1156913004953 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1156913004954 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913004955 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1156913004956 active site 1156913004957 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1156913004958 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1156913004959 short chain dehydrogenase; Region: adh_short; pfam00106 1156913004960 putative NADP binding site [chemical binding]; other site 1156913004961 active site 1156913004962 Polyketide synthase dehydratase; Region: PS-DH; pfam14765 1156913004963 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1156913004964 active site 1156913004965 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1156913004966 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1156913004967 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1156913004968 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1156913004969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913004970 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913004971 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1156913004972 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913004973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913004974 active site 1156913004975 phosphorylation site [posttranslational modification] 1156913004976 intermolecular recognition site; other site 1156913004977 dimerization interface [polypeptide binding]; other site 1156913004978 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913004979 DNA binding residues [nucleotide binding] 1156913004980 dimerization interface [polypeptide binding]; other site 1156913004981 Histidine kinase; Region: HisKA_3; pfam07730 1156913004982 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913004983 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1156913004984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913004985 Histidine kinase; Region: HisKA_3; pfam07730 1156913004986 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1156913004987 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913004988 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913004989 Adipokinetic hormone; Region: Adipokin_hormo; pfam06377 1156913004990 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913004991 DNA binding site [nucleotide binding] 1156913004992 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913004993 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913004994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913004995 active site 1156913004996 phosphorylation site [posttranslational modification] 1156913004997 intermolecular recognition site; other site 1156913004998 dimerization interface [polypeptide binding]; other site 1156913004999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913005000 DNA binding residues [nucleotide binding] 1156913005001 dimerization interface [polypeptide binding]; other site 1156913005002 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 1156913005003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913005004 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913005005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913005006 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913005007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913005008 active site 1156913005009 phosphorylation site [posttranslational modification] 1156913005010 intermolecular recognition site; other site 1156913005011 dimerization interface [polypeptide binding]; other site 1156913005012 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913005013 DNA binding residues [nucleotide binding] 1156913005014 dimerization interface [polypeptide binding]; other site 1156913005015 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1156913005016 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1156913005017 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1156913005018 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913005019 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1156913005020 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1156913005021 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1156913005022 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913005023 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913005024 active site 1156913005025 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1156913005026 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913005027 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1156913005028 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913005029 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913005030 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1156913005031 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1156913005032 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1156913005033 active site 1156913005034 DNA binding site [nucleotide binding] 1156913005035 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1156913005036 DNA binding site [nucleotide binding] 1156913005037 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1156913005038 nucleotide binding site [chemical binding]; other site 1156913005039 MarR family; Region: MarR_2; cl17246 1156913005040 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913005041 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1156913005042 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913005043 catalytic residue [active] 1156913005044 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1156913005045 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913005046 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913005047 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913005048 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913005049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913005050 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913005051 putative substrate translocation pore; other site 1156913005052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913005053 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 1156913005054 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1156913005055 multimer interface [polypeptide binding]; other site 1156913005056 active site 1156913005057 catalytic triad [active] 1156913005058 dimer interface [polypeptide binding]; other site 1156913005059 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 1156913005060 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1156913005061 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1156913005062 putative ligand binding site [chemical binding]; other site 1156913005063 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913005064 MarR family; Region: MarR_2; cl17246 1156913005065 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1156913005066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913005067 Coenzyme A binding pocket [chemical binding]; other site 1156913005068 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913005069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913005070 DNA binding residues [nucleotide binding] 1156913005071 dimerization interface [polypeptide binding]; other site 1156913005072 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913005073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913005074 Walker A/P-loop; other site 1156913005075 ATP binding site [chemical binding]; other site 1156913005076 Q-loop/lid; other site 1156913005077 ABC transporter signature motif; other site 1156913005078 Walker B; other site 1156913005079 D-loop; other site 1156913005080 H-loop/switch region; other site 1156913005081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913005082 dimer interface [polypeptide binding]; other site 1156913005083 conserved gate region; other site 1156913005084 ABC-ATPase subunit interface; other site 1156913005085 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1156913005086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913005087 substrate binding pocket [chemical binding]; other site 1156913005088 membrane-bound complex binding site; other site 1156913005089 hinge residues; other site 1156913005090 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1156913005091 Amidase; Region: Amidase; cl11426 1156913005092 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1156913005093 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1156913005094 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1156913005095 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913005096 active site 1156913005097 catalytic tetrad [active] 1156913005098 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1156913005099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913005100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913005101 homodimer interface [polypeptide binding]; other site 1156913005102 catalytic residue [active] 1156913005103 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913005104 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1156913005105 NAD(P) binding site [chemical binding]; other site 1156913005106 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1156913005107 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913005108 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913005109 catalytic residue [active] 1156913005110 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913005111 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1156913005112 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1156913005113 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913005114 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913005115 DNA binding site [nucleotide binding] 1156913005116 domain linker motif; other site 1156913005117 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1156913005118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913005119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913005120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913005121 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913005122 catalytic core [active] 1156913005123 Copper resistance protein D; Region: CopD; pfam05425 1156913005124 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1156913005125 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1156913005126 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1156913005127 dimer interface [polypeptide binding]; other site 1156913005128 ssDNA binding site [nucleotide binding]; other site 1156913005129 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1156913005130 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1156913005131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913005132 Walker A/P-loop; other site 1156913005133 ATP binding site [chemical binding]; other site 1156913005134 Q-loop/lid; other site 1156913005135 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913005136 ABC transporter; Region: ABC_tran_2; pfam12848 1156913005137 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913005138 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1156913005139 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1156913005140 active site 1156913005141 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1156913005142 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 1156913005143 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1156913005144 active site 1156913005145 catalytic site [active] 1156913005146 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1156913005147 apolar tunnel; other site 1156913005148 heme binding site [chemical binding]; other site 1156913005149 dimerization interface [polypeptide binding]; other site 1156913005150 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1156913005151 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1156913005152 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1156913005153 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913005154 active site 1156913005155 Repair protein; Region: Repair_PSII; pfam04536 1156913005156 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1156913005157 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1156913005158 Zn binding site [ion binding]; other site 1156913005159 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1156913005160 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1156913005161 catalytic residues [active] 1156913005162 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913005163 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 1156913005164 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1156913005165 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1156913005166 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1156913005167 putative DNA binding site [nucleotide binding]; other site 1156913005168 catalytic residue [active] 1156913005169 putative H2TH interface [polypeptide binding]; other site 1156913005170 putative catalytic residues [active] 1156913005171 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1156913005172 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1156913005173 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1156913005174 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913005175 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913005176 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1156913005177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913005178 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1156913005179 DNA binding residues [nucleotide binding] 1156913005180 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1156913005181 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1156913005182 active site 1156913005183 iron coordination sites [ion binding]; other site 1156913005184 substrate binding pocket [chemical binding]; other site 1156913005185 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1156913005186 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1156913005187 active site 1156913005188 non-prolyl cis peptide bond; other site 1156913005189 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1156913005190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913005191 dimer interface [polypeptide binding]; other site 1156913005192 conserved gate region; other site 1156913005193 putative PBP binding loops; other site 1156913005194 ABC-ATPase subunit interface; other site 1156913005195 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1156913005196 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1156913005197 Walker A/P-loop; other site 1156913005198 ATP binding site [chemical binding]; other site 1156913005199 Q-loop/lid; other site 1156913005200 ABC transporter signature motif; other site 1156913005201 Walker B; other site 1156913005202 D-loop; other site 1156913005203 H-loop/switch region; other site 1156913005204 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1156913005205 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913005206 substrate binding pocket [chemical binding]; other site 1156913005207 membrane-bound complex binding site; other site 1156913005208 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913005209 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1156913005210 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913005211 putative acetyltransferase; Provisional; Region: PRK03624 1156913005212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913005213 Coenzyme A binding pocket [chemical binding]; other site 1156913005214 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1156913005215 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913005216 dimerization interface [polypeptide binding]; other site 1156913005217 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1156913005218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913005219 dimerization interface [polypeptide binding]; other site 1156913005220 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913005221 dimerization interface [polypeptide binding]; other site 1156913005222 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1156913005223 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913005224 dimerization interface [polypeptide binding]; other site 1156913005225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913005226 dimerization interface [polypeptide binding]; other site 1156913005227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913005228 dimerization interface [polypeptide binding]; other site 1156913005229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913005230 dimerization interface [polypeptide binding]; other site 1156913005231 GAF domain; Region: GAF_2; pfam13185 1156913005232 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1156913005233 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913005234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913005235 dimer interface [polypeptide binding]; other site 1156913005236 phosphorylation site [posttranslational modification] 1156913005237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913005238 ATP binding site [chemical binding]; other site 1156913005239 Mg2+ binding site [ion binding]; other site 1156913005240 G-X-G motif; other site 1156913005241 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1156913005242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913005243 active site 1156913005244 phosphorylation site [posttranslational modification] 1156913005245 intermolecular recognition site; other site 1156913005246 dimerization interface [polypeptide binding]; other site 1156913005247 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1156913005248 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1156913005249 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1156913005250 active site 1156913005251 DNA binding site [nucleotide binding] 1156913005252 Int/Topo IB signature motif; other site 1156913005253 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1156913005254 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1156913005255 proposed catalytic triad [active] 1156913005256 conserved cys residue [active] 1156913005257 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913005258 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913005259 active site 1156913005260 ATP binding site [chemical binding]; other site 1156913005261 substrate binding site [chemical binding]; other site 1156913005262 activation loop (A-loop); other site 1156913005263 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1156913005264 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1156913005265 Peptidase family M48; Region: Peptidase_M48; cl12018 1156913005266 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913005267 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913005268 active site 1156913005269 catalytic tetrad [active] 1156913005270 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1156913005271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913005272 putative substrate translocation pore; other site 1156913005273 MarR family; Region: MarR; pfam01047 1156913005274 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1156913005275 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913005276 active site 1156913005277 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 1156913005278 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1156913005279 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1156913005280 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1156913005281 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913005282 active site 1156913005283 Predicted membrane protein [Function unknown]; Region: COG2246 1156913005284 GtrA-like protein; Region: GtrA; pfam04138 1156913005285 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1156913005286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1156913005287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913005288 dimer interface [polypeptide binding]; other site 1156913005289 phosphorylation site [posttranslational modification] 1156913005290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913005291 ATP binding site [chemical binding]; other site 1156913005292 Mg2+ binding site [ion binding]; other site 1156913005293 G-X-G motif; other site 1156913005294 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1156913005295 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1156913005296 putative di-iron ligands [ion binding]; other site 1156913005297 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1156913005298 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1156913005299 FAD binding pocket [chemical binding]; other site 1156913005300 FAD binding motif [chemical binding]; other site 1156913005301 phosphate binding motif [ion binding]; other site 1156913005302 beta-alpha-beta structure motif; other site 1156913005303 NAD(p) ribose binding residues [chemical binding]; other site 1156913005304 NAD binding pocket [chemical binding]; other site 1156913005305 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1156913005306 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913005307 catalytic loop [active] 1156913005308 iron binding site [ion binding]; other site 1156913005309 trigger factor; Provisional; Region: tig; PRK01490 1156913005310 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1156913005311 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1156913005312 Clp protease; Region: CLP_protease; pfam00574 1156913005313 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1156913005314 oligomer interface [polypeptide binding]; other site 1156913005315 active site residues [active] 1156913005316 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1156913005317 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1156913005318 oligomer interface [polypeptide binding]; other site 1156913005319 active site residues [active] 1156913005320 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1156913005321 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1156913005322 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1156913005323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913005324 Walker A motif; other site 1156913005325 ATP binding site [chemical binding]; other site 1156913005326 Walker B motif; other site 1156913005327 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1156913005328 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1156913005329 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1156913005330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1156913005331 Putative esterase; Region: Esterase; pfam00756 1156913005332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913005333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913005334 WHG domain; Region: WHG; pfam13305 1156913005335 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1156913005336 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1156913005337 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1156913005338 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1156913005339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913005340 putative substrate translocation pore; other site 1156913005341 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1156913005342 classical (c) SDRs; Region: SDR_c; cd05233 1156913005343 NAD(P) binding site [chemical binding]; other site 1156913005344 active site 1156913005345 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1156913005346 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1156913005347 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1156913005348 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1156913005349 putative molybdopterin cofactor binding site [chemical binding]; other site 1156913005350 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1156913005351 putative molybdopterin cofactor binding site; other site 1156913005352 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1156913005353 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1156913005354 active site 1156913005355 HIGH motif; other site 1156913005356 nucleotide binding site [chemical binding]; other site 1156913005357 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1156913005358 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1156913005359 active site 1156913005360 KMSKS motif; other site 1156913005361 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1156913005362 tRNA binding surface [nucleotide binding]; other site 1156913005363 anticodon binding site; other site 1156913005364 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1156913005365 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1156913005366 active site 1156913005367 catalytic triad [active] 1156913005368 oxyanion hole [active] 1156913005369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913005370 S-adenosylmethionine binding site [chemical binding]; other site 1156913005371 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1156913005372 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1156913005373 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1156913005374 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1156913005375 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913005376 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913005377 active site 1156913005378 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1156913005379 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1156913005380 putative active site [active] 1156913005381 putative metal binding site [ion binding]; other site 1156913005382 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913005383 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1156913005384 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913005385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913005386 putative Zn2+ binding site [ion binding]; other site 1156913005387 putative DNA binding site [nucleotide binding]; other site 1156913005388 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1156913005389 active site 1156913005390 multimer interface [polypeptide binding]; other site 1156913005391 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1156913005392 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913005393 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1156913005394 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1156913005395 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913005396 active site 1156913005397 metal binding site [ion binding]; metal-binding site 1156913005398 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1156913005399 active site 1156913005400 Zn binding site [ion binding]; other site 1156913005401 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913005402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913005403 Walker A/P-loop; other site 1156913005404 ATP binding site [chemical binding]; other site 1156913005405 Q-loop/lid; other site 1156913005406 ABC transporter signature motif; other site 1156913005407 Walker B; other site 1156913005408 D-loop; other site 1156913005409 H-loop/switch region; other site 1156913005410 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1156913005411 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913005412 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1156913005413 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913005414 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1156913005415 active site 1156913005416 catalytic residues [active] 1156913005417 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1156913005418 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1156913005419 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1156913005420 homodimer interface [polypeptide binding]; other site 1156913005421 oligonucleotide binding site [chemical binding]; other site 1156913005422 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1156913005423 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1156913005424 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1156913005425 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1156913005426 GTP1/OBG; Region: GTP1_OBG; pfam01018 1156913005427 Obg GTPase; Region: Obg; cd01898 1156913005428 G1 box; other site 1156913005429 GTP/Mg2+ binding site [chemical binding]; other site 1156913005430 Switch I region; other site 1156913005431 G2 box; other site 1156913005432 G3 box; other site 1156913005433 Switch II region; other site 1156913005434 G4 box; other site 1156913005435 G5 box; other site 1156913005436 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1156913005437 gamma-glutamyl kinase; Provisional; Region: PRK05429 1156913005438 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1156913005439 nucleotide binding site [chemical binding]; other site 1156913005440 homotetrameric interface [polypeptide binding]; other site 1156913005441 putative phosphate binding site [ion binding]; other site 1156913005442 putative allosteric binding site; other site 1156913005443 PUA domain; Region: PUA; pfam01472 1156913005444 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1156913005445 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1156913005446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913005447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913005448 DNA binding residues [nucleotide binding] 1156913005449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913005450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913005451 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1156913005452 hypothetical protein; Provisional; Region: PRK07236 1156913005453 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1156913005454 arginine-tRNA ligase; Region: PLN02286 1156913005455 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1156913005456 active site 1156913005457 HIGH motif; other site 1156913005458 KMSK motif region; other site 1156913005459 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1156913005460 tRNA binding surface [nucleotide binding]; other site 1156913005461 anticodon binding site; other site 1156913005462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913005463 metabolite-proton symporter; Region: 2A0106; TIGR00883 1156913005464 putative substrate translocation pore; other site 1156913005465 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1156913005466 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913005467 ATP binding site [chemical binding]; other site 1156913005468 putative Mg++ binding site [ion binding]; other site 1156913005469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913005470 nucleotide binding region [chemical binding]; other site 1156913005471 ATP-binding site [chemical binding]; other site 1156913005472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1156913005473 active site 1156913005474 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1156913005475 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1156913005476 active site 1156913005477 (T/H)XGH motif; other site 1156913005478 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1156913005479 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913005480 catalytic core [active] 1156913005481 EDD domain protein, DegV family; Region: DegV; TIGR00762 1156913005482 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1156913005483 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1156913005484 SLBB domain; Region: SLBB; pfam10531 1156913005485 Helix-hairpin-helix motif; Region: HHH; pfam00633 1156913005486 Competence protein; Region: Competence; pfam03772 1156913005487 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913005488 threonine synthase; Validated; Region: PRK07591 1156913005489 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1156913005490 homodimer interface [polypeptide binding]; other site 1156913005491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913005492 catalytic residue [active] 1156913005493 hypothetical protein; Reviewed; Region: PRK07914 1156913005494 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1156913005495 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1156913005496 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1156913005497 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1156913005498 EamA-like transporter family; Region: EamA; pfam00892 1156913005499 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913005500 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913005501 active site 1156913005502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913005503 GTP-binding protein LepA; Provisional; Region: PRK05433 1156913005504 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1156913005505 G1 box; other site 1156913005506 putative GEF interaction site [polypeptide binding]; other site 1156913005507 GTP/Mg2+ binding site [chemical binding]; other site 1156913005508 Switch I region; other site 1156913005509 G2 box; other site 1156913005510 G3 box; other site 1156913005511 Switch II region; other site 1156913005512 G4 box; other site 1156913005513 G5 box; other site 1156913005514 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1156913005515 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1156913005516 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1156913005517 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1156913005518 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 1156913005519 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1156913005520 active site 1156913005521 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1156913005522 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1156913005523 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1156913005524 Nitronate monooxygenase; Region: NMO; pfam03060 1156913005525 FMN binding site [chemical binding]; other site 1156913005526 substrate binding site [chemical binding]; other site 1156913005527 putative catalytic residue [active] 1156913005528 amino acid transporter; Region: 2A0306; TIGR00909 1156913005529 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1156913005530 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913005531 Serine hydrolase; Region: Ser_hydrolase; cl17834 1156913005532 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913005533 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913005534 NAD(P) binding site [chemical binding]; other site 1156913005535 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1156913005536 active site 1156913005537 barstar interaction site; other site 1156913005538 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 1156913005539 putative RNAase interaction site [polypeptide binding]; other site 1156913005540 enoyl-CoA hydratase; Provisional; Region: PRK07827 1156913005541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913005542 substrate binding site [chemical binding]; other site 1156913005543 oxyanion hole (OAH) forming residues; other site 1156913005544 trimer interface [polypeptide binding]; other site 1156913005545 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1156913005546 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1156913005547 putative active site [active] 1156913005548 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1156913005549 putative active site [active] 1156913005550 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1156913005551 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1156913005552 CysD dimerization site [polypeptide binding]; other site 1156913005553 G1 box; other site 1156913005554 putative GEF interaction site [polypeptide binding]; other site 1156913005555 GTP/Mg2+ binding site [chemical binding]; other site 1156913005556 Switch I region; other site 1156913005557 G2 box; other site 1156913005558 G3 box; other site 1156913005559 Switch II region; other site 1156913005560 G4 box; other site 1156913005561 G5 box; other site 1156913005562 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1156913005563 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1156913005564 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1156913005565 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1156913005566 Active Sites [active] 1156913005567 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1156913005568 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1156913005569 Active Sites [active] 1156913005570 60S ribosomal protein L37a; Provisional; Region: PTZ00255; cl00875 1156913005571 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1156913005572 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1156913005573 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1156913005574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913005575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913005576 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1156913005577 putative dimer interface [polypeptide binding]; other site 1156913005578 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913005579 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1156913005580 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1156913005581 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1156913005582 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1156913005583 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1156913005584 Ligand binding site; other site 1156913005585 Putative Catalytic site; other site 1156913005586 DXD motif; other site 1156913005587 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1156913005588 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1156913005589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913005590 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913005591 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1156913005592 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1156913005593 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1156913005594 FAD binding pocket [chemical binding]; other site 1156913005595 FAD binding motif [chemical binding]; other site 1156913005596 phosphate binding motif [ion binding]; other site 1156913005597 NAD binding pocket [chemical binding]; other site 1156913005598 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913005599 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913005600 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913005601 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913005602 hypothetical protein; Provisional; Region: PRK06834 1156913005603 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913005604 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913005605 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 1156913005606 phenylhydantoinase; Validated; Region: PRK08323 1156913005607 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1156913005608 tetramer interface [polypeptide binding]; other site 1156913005609 active site 1156913005610 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1156913005611 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1156913005612 active site 1156913005613 catalytic triad [active] 1156913005614 dimer interface [polypeptide binding]; other site 1156913005615 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1156913005616 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1156913005617 Na binding site [ion binding]; other site 1156913005618 putative substrate binding site [chemical binding]; other site 1156913005619 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913005620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913005621 active site 1156913005622 phosphorylation site [posttranslational modification] 1156913005623 intermolecular recognition site; other site 1156913005624 dimerization interface [polypeptide binding]; other site 1156913005625 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913005626 DNA binding site [nucleotide binding] 1156913005627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913005628 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913005629 dimerization interface [polypeptide binding]; other site 1156913005630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913005631 dimer interface [polypeptide binding]; other site 1156913005632 phosphorylation site [posttranslational modification] 1156913005633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913005634 ATP binding site [chemical binding]; other site 1156913005635 Mg2+ binding site [ion binding]; other site 1156913005636 G-X-G motif; other site 1156913005637 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1156913005638 Subtilisin inhibitor-like; Region: SSI; cl11594 1156913005639 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1156913005640 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913005641 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1156913005642 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1156913005643 tetrameric interface [polypeptide binding]; other site 1156913005644 NAD binding site [chemical binding]; other site 1156913005645 catalytic residues [active] 1156913005646 Secretory lipase; Region: LIP; pfam03583 1156913005647 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1156913005648 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1156913005649 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1156913005650 chaperone protein DnaJ; Provisional; Region: PRK14278 1156913005651 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1156913005652 HSP70 interaction site [polypeptide binding]; other site 1156913005653 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1156913005654 Zn binding sites [ion binding]; other site 1156913005655 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1156913005656 dimer interface [polypeptide binding]; other site 1156913005657 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1156913005658 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1156913005659 nucleotide binding site/active site [active] 1156913005660 HIT family signature motif; other site 1156913005661 catalytic residue [active] 1156913005662 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1156913005663 PhoH-like protein; Region: PhoH; pfam02562 1156913005664 metal-binding heat shock protein; Provisional; Region: PRK00016 1156913005665 Domain of unknown function DUF21; Region: DUF21; pfam01595 1156913005666 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1156913005667 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1156913005668 Transporter associated domain; Region: CorC_HlyC; smart01091 1156913005669 GTPase Era; Reviewed; Region: era; PRK00089 1156913005670 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1156913005671 G1 box; other site 1156913005672 GTP/Mg2+ binding site [chemical binding]; other site 1156913005673 Switch I region; other site 1156913005674 G2 box; other site 1156913005675 Switch II region; other site 1156913005676 G3 box; other site 1156913005677 G4 box; other site 1156913005678 G5 box; other site 1156913005679 KH domain; Region: KH_2; pfam07650 1156913005680 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1156913005681 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1156913005682 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1156913005683 RDD family; Region: RDD; pfam06271 1156913005684 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1156913005685 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1156913005686 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1156913005687 Recombination protein O N terminal; Region: RecO_N; pfam11967 1156913005688 Recombination protein O C terminal; Region: RecO_C; pfam02565 1156913005689 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1156913005690 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1156913005691 catalytic residue [active] 1156913005692 putative FPP diphosphate binding site; other site 1156913005693 putative FPP binding hydrophobic cleft; other site 1156913005694 dimer interface [polypeptide binding]; other site 1156913005695 putative IPP diphosphate binding site; other site 1156913005696 Predicted permease; Region: DUF318; cl17795 1156913005697 TIGR03943 family protein; Region: TIGR03943 1156913005698 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1156913005699 metal binding site 2 [ion binding]; metal-binding site 1156913005700 putative DNA binding helix; other site 1156913005701 metal binding site 1 [ion binding]; metal-binding site 1156913005702 dimer interface [polypeptide binding]; other site 1156913005703 structural Zn2+ binding site [ion binding]; other site 1156913005704 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913005705 putative DNA binding site [nucleotide binding]; other site 1156913005706 putative Zn2+ binding site [ion binding]; other site 1156913005707 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1156913005708 active site 1156913005709 putative catalytic site [active] 1156913005710 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1156913005711 active site 1156913005712 putative catalytic site [active] 1156913005713 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1156913005714 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1156913005715 motif 1; other site 1156913005716 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1156913005717 motif 1; other site 1156913005718 dimer interface [polypeptide binding]; other site 1156913005719 active site 1156913005720 motif 2; other site 1156913005721 motif 3; other site 1156913005722 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1156913005723 anticodon binding site; other site 1156913005724 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913005725 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913005726 Walker A/P-loop; other site 1156913005727 ATP binding site [chemical binding]; other site 1156913005728 Q-loop/lid; other site 1156913005729 ABC transporter signature motif; other site 1156913005730 Walker B; other site 1156913005731 D-loop; other site 1156913005732 H-loop/switch region; other site 1156913005733 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913005734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913005735 Histidine kinase; Region: HisKA_3; pfam07730 1156913005736 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913005737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913005738 active site 1156913005739 phosphorylation site [posttranslational modification] 1156913005740 intermolecular recognition site; other site 1156913005741 dimerization interface [polypeptide binding]; other site 1156913005742 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913005743 DNA binding residues [nucleotide binding] 1156913005744 dimerization interface [polypeptide binding]; other site 1156913005745 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1156913005746 putative active site [active] 1156913005747 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1156913005748 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1156913005749 Zn2+ binding site [ion binding]; other site 1156913005750 Mg2+ binding site [ion binding]; other site 1156913005751 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1156913005752 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 1156913005753 reactive center loop; other site 1156913005754 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913005755 NAD(P) binding site [chemical binding]; other site 1156913005756 catalytic residues [active] 1156913005757 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1156913005758 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1156913005759 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1156913005760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913005761 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1156913005762 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913005763 DNA primase; Validated; Region: dnaG; PRK05667 1156913005764 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1156913005765 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1156913005766 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1156913005767 active site 1156913005768 metal binding site [ion binding]; metal-binding site 1156913005769 interdomain interaction site; other site 1156913005770 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1156913005771 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1156913005772 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1156913005773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913005774 S-adenosylmethionine binding site [chemical binding]; other site 1156913005775 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1156913005776 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1156913005777 putative sugar binding sites [chemical binding]; other site 1156913005778 Q-X-W motif; other site 1156913005779 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1156913005780 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913005781 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913005782 haloalkane dehalogenase; Provisional; Region: PRK03204 1156913005783 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913005784 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913005785 active site 1156913005786 Family description; Region: VCBS; pfam13517 1156913005787 AAA ATPase domain; Region: AAA_16; pfam13191 1156913005788 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913005789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913005790 DNA binding residues [nucleotide binding] 1156913005791 dimerization interface [polypeptide binding]; other site 1156913005792 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913005793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913005794 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913005795 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1156913005796 NAD(P) binding site [chemical binding]; other site 1156913005797 active site 1156913005798 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 1156913005799 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913005800 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913005801 active site 1156913005802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913005803 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913005804 non-specific DNA binding site [nucleotide binding]; other site 1156913005805 salt bridge; other site 1156913005806 sequence-specific DNA binding site [nucleotide binding]; other site 1156913005807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913005808 AAA domain; Region: AAA_22; pfam13401 1156913005809 Walker A motif; other site 1156913005810 ATP binding site [chemical binding]; other site 1156913005811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913005812 HTH domain; Region: HTH_11; pfam08279 1156913005813 WYL domain; Region: WYL; pfam13280 1156913005814 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913005815 amino acid transporter; Region: 2A0306; TIGR00909 1156913005816 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1156913005817 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1156913005818 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1156913005819 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1156913005820 tetramer interface [polypeptide binding]; other site 1156913005821 active site 1156913005822 Mg2+/Mn2+ binding site [ion binding]; other site 1156913005823 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1156913005824 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913005825 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1156913005826 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1156913005827 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1156913005828 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913005829 short chain dehydrogenase; Provisional; Region: PRK07326 1156913005830 classical (c) SDRs; Region: SDR_c; cd05233 1156913005831 NAD(P) binding site [chemical binding]; other site 1156913005832 active site 1156913005833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913005834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913005835 Secretory lipase; Region: LIP; pfam03583 1156913005836 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1156913005837 NB-ARC domain; Region: NB-ARC; pfam00931 1156913005838 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913005839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913005840 binding surface 1156913005841 TPR motif; other site 1156913005842 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913005843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913005844 binding surface 1156913005845 TPR repeat; Region: TPR_11; pfam13414 1156913005846 TPR motif; other site 1156913005847 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913005848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913005849 binding surface 1156913005850 TPR motif; other site 1156913005851 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913005852 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1156913005853 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1156913005854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913005855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913005856 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1156913005857 argininosuccinate synthase; Validated; Region: PRK05370 1156913005858 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1156913005859 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1156913005860 Moco binding site; other site 1156913005861 metal coordination site [ion binding]; other site 1156913005862 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1156913005863 Fasciclin domain; Region: Fasciclin; pfam02469 1156913005864 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913005865 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913005866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913005867 DNA binding residues [nucleotide binding] 1156913005868 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913005869 MarR family; Region: MarR; pfam01047 1156913005870 hypothetical protein; Provisional; Region: PRK07236 1156913005871 hypothetical protein; Provisional; Region: PRK07588 1156913005872 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1156913005873 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1156913005874 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1156913005875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913005876 NAD(P) binding site [chemical binding]; other site 1156913005877 active site 1156913005878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913005879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913005880 dimerization interface [polypeptide binding]; other site 1156913005881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913005882 dimer interface [polypeptide binding]; other site 1156913005883 phosphorylation site [posttranslational modification] 1156913005884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913005885 ATP binding site [chemical binding]; other site 1156913005886 Mg2+ binding site [ion binding]; other site 1156913005887 G-X-G motif; other site 1156913005888 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913005889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913005890 active site 1156913005891 phosphorylation site [posttranslational modification] 1156913005892 intermolecular recognition site; other site 1156913005893 dimerization interface [polypeptide binding]; other site 1156913005894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913005895 DNA binding site [nucleotide binding] 1156913005896 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1156913005897 putative active site; other site 1156913005898 putative metal binding residues [ion binding]; other site 1156913005899 signature motif; other site 1156913005900 putative triphosphate binding site [ion binding]; other site 1156913005901 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1156913005902 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1156913005903 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1156913005904 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913005905 DNA binding site [nucleotide binding] 1156913005906 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913005907 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913005908 Predicted ATPase [General function prediction only]; Region: COG3903 1156913005909 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1156913005910 short chain dehydrogenase; Provisional; Region: PRK06500 1156913005911 classical (c) SDRs; Region: SDR_c; cd05233 1156913005912 NAD(P) binding site [chemical binding]; other site 1156913005913 active site 1156913005914 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1156913005915 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913005916 DNA binding residues [nucleotide binding] 1156913005917 TROVE domain; Region: TROVE; pfam05731 1156913005918 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1156913005919 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1156913005920 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1156913005921 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1156913005922 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913005923 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913005924 DNA binding residues [nucleotide binding] 1156913005925 Transcription factor WhiB; Region: Whib; pfam02467 1156913005926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913005927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913005928 putative substrate translocation pore; other site 1156913005929 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1156913005930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913005931 short chain dehydrogenase; Provisional; Region: PRK08251 1156913005932 classical (c) SDRs; Region: SDR_c; cd05233 1156913005933 NAD(P) binding site [chemical binding]; other site 1156913005934 active site 1156913005935 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1156913005936 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913005937 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913005938 active site 1156913005939 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1156913005940 acyl-coenzyme A oxidase; Region: PLN02526 1156913005941 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913005942 active site 1156913005943 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 1156913005944 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1156913005945 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1156913005946 acetoacetate decarboxylase; Provisional; Region: PRK02265 1156913005947 enoyl-CoA hydratase; Provisional; Region: PRK08252 1156913005948 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913005949 substrate binding site [chemical binding]; other site 1156913005950 oxyanion hole (OAH) forming residues; other site 1156913005951 trimer interface [polypeptide binding]; other site 1156913005952 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1156913005953 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1156913005954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913005955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913005956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913005957 dimerization interface [polypeptide binding]; other site 1156913005958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913005959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913005960 dimerization interface [polypeptide binding]; other site 1156913005961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913005962 dimer interface [polypeptide binding]; other site 1156913005963 phosphorylation site [posttranslational modification] 1156913005964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913005965 ATP binding site [chemical binding]; other site 1156913005966 Mg2+ binding site [ion binding]; other site 1156913005967 G-X-G motif; other site 1156913005968 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913005969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913005970 active site 1156913005971 phosphorylation site [posttranslational modification] 1156913005972 intermolecular recognition site; other site 1156913005973 dimerization interface [polypeptide binding]; other site 1156913005974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913005975 DNA binding site [nucleotide binding] 1156913005976 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1156913005977 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1156913005978 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1156913005979 putative hydrophobic ligand binding site [chemical binding]; other site 1156913005980 protein interface [polypeptide binding]; other site 1156913005981 gate; other site 1156913005982 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913005983 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913005984 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913005985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913005986 dimerization interface [polypeptide binding]; other site 1156913005987 putative DNA binding site [nucleotide binding]; other site 1156913005988 putative Zn2+ binding site [ion binding]; other site 1156913005989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913005990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913005991 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1156913005992 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1156913005993 Bacterial PH domain; Region: DUF304; pfam03703 1156913005994 Bacterial PH domain; Region: DUF304; cl01348 1156913005995 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1156913005996 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1156913005997 tetramer interface [polypeptide binding]; other site 1156913005998 active site 1156913005999 Mg2+/Mn2+ binding site [ion binding]; other site 1156913006000 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1156913006001 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913006002 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913006003 catalytic residue [active] 1156913006004 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1156913006005 dinuclear metal binding motif [ion binding]; other site 1156913006006 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1156913006007 Sm and related proteins; Region: Sm_like; cl00259 1156913006008 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1156913006009 putative oligomer interface [polypeptide binding]; other site 1156913006010 putative RNA binding site [nucleotide binding]; other site 1156913006011 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1156913006012 NusA N-terminal domain; Region: NusA_N; pfam08529 1156913006013 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1156913006014 RNA binding site [nucleotide binding]; other site 1156913006015 homodimer interface [polypeptide binding]; other site 1156913006016 NusA-like KH domain; Region: KH_5; pfam13184 1156913006017 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1156913006018 G-X-X-G motif; other site 1156913006019 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1156913006020 putative RNA binding cleft [nucleotide binding]; other site 1156913006021 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1156913006022 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1156913006023 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1156913006024 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1156913006025 G1 box; other site 1156913006026 putative GEF interaction site [polypeptide binding]; other site 1156913006027 GTP/Mg2+ binding site [chemical binding]; other site 1156913006028 Switch I region; other site 1156913006029 G2 box; other site 1156913006030 G3 box; other site 1156913006031 Switch II region; other site 1156913006032 G4 box; other site 1156913006033 G5 box; other site 1156913006034 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1156913006035 Translation-initiation factor 2; Region: IF-2; pfam11987 1156913006036 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1156913006037 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1156913006038 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1156913006039 Putative esterase; Region: Esterase; pfam00756 1156913006040 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1156913006041 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1156913006042 DHH family; Region: DHH; pfam01368 1156913006043 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1156913006044 SecY translocase; Region: SecY; pfam00344 1156913006045 Family description; Region: VCBS; pfam13517 1156913006046 Family description; Region: VCBS; pfam13517 1156913006047 Family description; Region: VCBS; pfam13517 1156913006048 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913006049 DNA binding site [nucleotide binding] 1156913006050 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913006051 NB-ARC domain; Region: NB-ARC; pfam00931 1156913006052 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913006053 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1156913006054 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1156913006055 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1156913006056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913006057 putative substrate translocation pore; other site 1156913006058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913006059 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1156913006060 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1156913006061 RNA binding site [nucleotide binding]; other site 1156913006062 active site 1156913006063 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1156913006064 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1156913006065 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1156913006066 active site 1156913006067 Riboflavin kinase; Region: Flavokinase; smart00904 1156913006068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913006069 non-specific DNA binding site [nucleotide binding]; other site 1156913006070 salt bridge; other site 1156913006071 sequence-specific DNA binding site [nucleotide binding]; other site 1156913006072 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1156913006073 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1156913006074 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1156913006075 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1156913006076 16S/18S rRNA binding site [nucleotide binding]; other site 1156913006077 S13e-L30e interaction site [polypeptide binding]; other site 1156913006078 25S rRNA binding site [nucleotide binding]; other site 1156913006079 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1156913006080 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1156913006081 oligomer interface [polypeptide binding]; other site 1156913006082 RNA binding site [nucleotide binding]; other site 1156913006083 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1156913006084 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1156913006085 RNase E interface [polypeptide binding]; other site 1156913006086 trimer interface [polypeptide binding]; other site 1156913006087 active site 1156913006088 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1156913006089 putative nucleic acid binding region [nucleotide binding]; other site 1156913006090 G-X-X-G motif; other site 1156913006091 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1156913006092 RNA binding site [nucleotide binding]; other site 1156913006093 domain interface; other site 1156913006094 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1156913006095 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1156913006096 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1156913006097 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1156913006098 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1156913006099 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1156913006100 TPR motif; other site 1156913006101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1156913006102 GtrA-like protein; Region: GtrA; pfam04138 1156913006103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1156913006104 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1156913006105 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1156913006106 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1156913006107 HicB family; Region: HicB; pfam05534 1156913006108 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1156913006109 Uncharacterized conserved protein [Function unknown]; Region: COG3603 1156913006110 Family description; Region: ACT_7; pfam13840 1156913006111 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913006112 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913006113 active site 1156913006114 ATP binding site [chemical binding]; other site 1156913006115 substrate binding site [chemical binding]; other site 1156913006116 activation loop (A-loop); other site 1156913006117 Septum formation; Region: Septum_form; pfam13845 1156913006118 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1156913006119 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1156913006120 dimer interface [polypeptide binding]; other site 1156913006121 active site 1156913006122 catalytic residue [active] 1156913006123 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1156913006124 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1156913006125 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1156913006126 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1156913006127 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1156913006128 EamA-like transporter family; Region: EamA; pfam00892 1156913006129 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1156913006130 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1156913006131 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1156913006132 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1156913006133 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1156913006134 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1156913006135 putative acyl-acceptor binding pocket; other site 1156913006136 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1156913006137 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913006138 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1156913006139 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1156913006140 FMN binding site [chemical binding]; other site 1156913006141 dimer interface [polypeptide binding]; other site 1156913006142 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913006143 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1156913006144 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913006145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913006146 Coenzyme A binding pocket [chemical binding]; other site 1156913006147 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1156913006148 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1156913006149 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913006150 FeS/SAM binding site; other site 1156913006151 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1156913006152 Competence-damaged protein; Region: CinA; pfam02464 1156913006153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913006154 non-specific DNA binding site [nucleotide binding]; other site 1156913006155 salt bridge; other site 1156913006156 sequence-specific DNA binding site [nucleotide binding]; other site 1156913006157 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1156913006158 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1156913006159 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1156913006160 allophanate hydrolase; Provisional; Region: PRK08186 1156913006161 Amidase; Region: Amidase; cl11426 1156913006162 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1156913006163 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1156913006164 quinone interaction residues [chemical binding]; other site 1156913006165 active site 1156913006166 catalytic residues [active] 1156913006167 FMN binding site [chemical binding]; other site 1156913006168 substrate binding site [chemical binding]; other site 1156913006169 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1156913006170 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913006171 adenosine deaminase; Provisional; Region: PRK09358 1156913006172 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1156913006173 active site 1156913006174 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1156913006175 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1156913006176 putative DNA binding site [nucleotide binding]; other site 1156913006177 catalytic residue [active] 1156913006178 putative H2TH interface [polypeptide binding]; other site 1156913006179 putative catalytic residues [active] 1156913006180 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1156913006181 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1156913006182 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1156913006183 P-loop; other site 1156913006184 Magnesium ion binding site [ion binding]; other site 1156913006185 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1156913006186 Magnesium ion binding site [ion binding]; other site 1156913006187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913006188 S-adenosylmethionine binding site [chemical binding]; other site 1156913006189 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1156913006190 active site 1156913006191 DNA polymerase IV; Validated; Region: PRK02406 1156913006192 DNA binding site [nucleotide binding] 1156913006193 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1156913006194 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1156913006195 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1156913006196 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1156913006197 Protein of unknown function DUF58; Region: DUF58; pfam01882 1156913006198 MoxR-like ATPases [General function prediction only]; Region: COG0714 1156913006199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913006200 ATP binding site [chemical binding]; other site 1156913006201 Walker A motif; other site 1156913006202 Walker B motif; other site 1156913006203 arginine finger; other site 1156913006204 EspG family; Region: ESX-1_EspG; pfam14011 1156913006205 cell division protein MraZ; Reviewed; Region: PRK00326 1156913006206 MraZ protein; Region: MraZ; pfam02381 1156913006207 MraZ protein; Region: MraZ; pfam02381 1156913006208 MraW methylase family; Region: Methyltransf_5; cl17771 1156913006209 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1156913006210 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1156913006211 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1156913006212 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1156913006213 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1156913006214 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1156913006215 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1156913006216 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1156913006217 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1156913006218 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1156913006219 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1156913006220 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1156913006221 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1156913006222 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1156913006223 Mg++ binding site [ion binding]; other site 1156913006224 putative catalytic motif [active] 1156913006225 putative substrate binding site [chemical binding]; other site 1156913006226 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1156913006227 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913006228 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1156913006229 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1156913006230 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1156913006231 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1156913006232 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1156913006233 homodimer interface [polypeptide binding]; other site 1156913006234 active site 1156913006235 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1156913006236 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1156913006237 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1156913006238 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1156913006239 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1156913006240 Cell division protein FtsQ; Region: FtsQ; pfam03799 1156913006241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913006242 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1156913006243 DNA-binding interface [nucleotide binding]; DNA binding site 1156913006244 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913006245 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1156913006246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913006247 NAD(P) binding site [chemical binding]; other site 1156913006248 active site 1156913006249 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913006250 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913006251 active site 1156913006252 ATP binding site [chemical binding]; other site 1156913006253 substrate binding site [chemical binding]; other site 1156913006254 activation loop (A-loop); other site 1156913006255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1156913006256 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1156913006257 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1156913006258 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1156913006259 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1156913006260 Helix-turn-helix domain; Region: HTH_17; pfam12728 1156913006261 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913006262 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1156913006263 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913006264 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1156913006265 active site lid residues [active] 1156913006266 substrate binding pocket [chemical binding]; other site 1156913006267 catalytic residues [active] 1156913006268 substrate-Mg2+ binding site; other site 1156913006269 aspartate-rich region 1; other site 1156913006270 aspartate-rich region 2; other site 1156913006271 phytoene desaturase; Region: crtI_fam; TIGR02734 1156913006272 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1156913006273 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1156913006274 substrate binding pocket [chemical binding]; other site 1156913006275 chain length determination region; other site 1156913006276 substrate-Mg2+ binding site; other site 1156913006277 catalytic residues [active] 1156913006278 aspartate-rich region 1; other site 1156913006279 active site lid residues [active] 1156913006280 aspartate-rich region 2; other site 1156913006281 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1156913006282 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1156913006283 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913006284 AzlC protein; Region: AzlC; cl00570 1156913006285 Alkylmercury lyase; Region: MerB; pfam03243 1156913006286 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1156913006287 FAD binding site [chemical binding]; other site 1156913006288 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1156913006289 EamA-like transporter family; Region: EamA; pfam00892 1156913006290 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1156913006291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1156913006292 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1156913006293 putative deacylase active site [active] 1156913006294 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913006295 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1156913006296 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1156913006297 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1156913006298 active site 1156913006299 catalytic residues [active] 1156913006300 metal binding site [ion binding]; metal-binding site 1156913006301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913006302 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1156913006303 ATP binding site [chemical binding]; other site 1156913006304 putative Mg++ binding site [ion binding]; other site 1156913006305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913006306 nucleotide binding region [chemical binding]; other site 1156913006307 ATP-binding site [chemical binding]; other site 1156913006308 DEAD/H associated; Region: DEAD_assoc; pfam08494 1156913006309 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1156913006310 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 1156913006311 nucleotide binding site [chemical binding]; other site 1156913006312 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1156913006313 SBD interface [polypeptide binding]; other site 1156913006314 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1156913006315 recombinase A; Provisional; Region: recA; PRK09354 1156913006316 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1156913006317 hexamer interface [polypeptide binding]; other site 1156913006318 Walker A motif; other site 1156913006319 ATP binding site [chemical binding]; other site 1156913006320 Walker B motif; other site 1156913006321 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1156913006322 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1156913006323 active site 1156913006324 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1156913006325 active site 1156913006326 metal binding site [ion binding]; metal-binding site 1156913006327 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1156913006328 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1156913006329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913006330 Coenzyme A binding pocket [chemical binding]; other site 1156913006331 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1156913006332 active site 1156913006333 intersubunit interface [polypeptide binding]; other site 1156913006334 catalytic residue [active] 1156913006335 phosphogluconate dehydratase; Validated; Region: PRK09054 1156913006336 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1156913006337 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1156913006338 L-aspartate oxidase; Provisional; Region: PRK06175 1156913006339 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1156913006340 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1156913006341 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913006342 catalytic loop [active] 1156913006343 iron binding site [ion binding]; other site 1156913006344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913006345 S-adenosylmethionine binding site [chemical binding]; other site 1156913006346 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1156913006347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913006348 dimer interface [polypeptide binding]; other site 1156913006349 conserved gate region; other site 1156913006350 putative PBP binding loops; other site 1156913006351 ABC-ATPase subunit interface; other site 1156913006352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913006353 dimer interface [polypeptide binding]; other site 1156913006354 conserved gate region; other site 1156913006355 putative PBP binding loops; other site 1156913006356 ABC-ATPase subunit interface; other site 1156913006357 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1156913006358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913006359 substrate binding pocket [chemical binding]; other site 1156913006360 membrane-bound complex binding site; other site 1156913006361 hinge residues; other site 1156913006362 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1156913006363 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1156913006364 Walker A/P-loop; other site 1156913006365 ATP binding site [chemical binding]; other site 1156913006366 Q-loop/lid; other site 1156913006367 ABC transporter signature motif; other site 1156913006368 Walker B; other site 1156913006369 D-loop; other site 1156913006370 H-loop/switch region; other site 1156913006371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913006372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1156913006373 dimerization interface [polypeptide binding]; other site 1156913006374 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913006375 DNA binding site [nucleotide binding] 1156913006376 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913006377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1156913006378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913006379 phosphorylation site [posttranslational modification] 1156913006380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913006381 ATP binding site [chemical binding]; other site 1156913006382 Mg2+ binding site [ion binding]; other site 1156913006383 G-X-G motif; other site 1156913006384 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1156913006385 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913006386 membrane-bound complex binding site; other site 1156913006387 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1156913006388 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1156913006389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913006390 FeS/SAM binding site; other site 1156913006391 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1156913006392 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1156913006393 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1156913006394 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1156913006395 active site 1156913006396 metal binding site [ion binding]; metal-binding site 1156913006397 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1156913006398 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1156913006399 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1156913006400 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1156913006401 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1156913006402 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913006403 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913006404 putative DNA binding site [nucleotide binding]; other site 1156913006405 putative Zn2+ binding site [ion binding]; other site 1156913006406 GTPases [General function prediction only]; Region: HflX; COG2262 1156913006407 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1156913006408 HflX GTPase family; Region: HflX; cd01878 1156913006409 G1 box; other site 1156913006410 GTP/Mg2+ binding site [chemical binding]; other site 1156913006411 Switch I region; other site 1156913006412 G2 box; other site 1156913006413 G3 box; other site 1156913006414 Switch II region; other site 1156913006415 G4 box; other site 1156913006416 G5 box; other site 1156913006417 LexA repressor; Validated; Region: PRK00215 1156913006418 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1156913006419 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1156913006420 Catalytic site [active] 1156913006421 ATP cone domain; Region: ATP-cone; pfam03477 1156913006422 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1156913006423 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1156913006424 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1156913006425 active site 1156913006426 dimer interface [polypeptide binding]; other site 1156913006427 effector binding site; other site 1156913006428 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1156913006429 TSCPD domain; Region: TSCPD; pfam12637 1156913006430 AAA domain; Region: AAA_17; pfam13207 1156913006431 DoxX-like family; Region: DoxX_2; pfam13564 1156913006432 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 1156913006433 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1156913006434 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1156913006435 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913006436 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1156913006437 putative hydrophobic ligand binding site [chemical binding]; other site 1156913006438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913006439 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1156913006440 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1156913006441 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1156913006442 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913006443 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1156913006444 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1156913006445 FOG: CBS domain [General function prediction only]; Region: COG0517 1156913006446 conserved hypothetical protein; Region: TIGR02231 1156913006447 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1156913006448 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1156913006449 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1156913006450 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913006451 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1156913006452 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1156913006453 Peptidase family M23; Region: Peptidase_M23; pfam01551 1156913006454 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1156913006455 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1156913006456 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1156913006457 NAD binding site [chemical binding]; other site 1156913006458 homodimer interface [polypeptide binding]; other site 1156913006459 active site 1156913006460 substrate binding site [chemical binding]; other site 1156913006461 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1156913006462 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1156913006463 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1156913006464 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1156913006465 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1156913006466 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1156913006467 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1156913006468 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1156913006469 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1156913006470 active site residue [active] 1156913006471 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1156913006472 active site residue [active] 1156913006473 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1156913006474 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1156913006475 active site 1156913006476 Zn binding site [ion binding]; other site 1156913006477 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913006478 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913006479 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1156913006480 CoA binding domain; Region: CoA_binding_2; pfam13380 1156913006481 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1156913006482 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1156913006483 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1156913006484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913006485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913006486 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913006487 acyl-CoA synthetase; Validated; Region: PRK07867 1156913006488 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913006489 acyl-activating enzyme (AAE) consensus motif; other site 1156913006490 AMP binding site [chemical binding]; other site 1156913006491 active site 1156913006492 CoA binding site [chemical binding]; other site 1156913006493 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006494 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913006495 active site 1156913006496 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006497 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1156913006498 FAD binding site [chemical binding]; other site 1156913006499 substrate binding site [chemical binding]; other site 1156913006500 catalytic base [active] 1156913006501 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1156913006502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913006503 NAD(P) binding site [chemical binding]; other site 1156913006504 active site 1156913006505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913006506 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913006507 NAD(P) binding site [chemical binding]; other site 1156913006508 active site 1156913006509 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1156913006510 Permease; Region: Permease; pfam02405 1156913006511 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1156913006512 Permease; Region: Permease; pfam02405 1156913006513 mce related protein; Region: MCE; pfam02470 1156913006514 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1156913006515 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913006516 mce related protein; Region: MCE; pfam02470 1156913006517 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913006518 mce related protein; Region: MCE; pfam02470 1156913006519 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913006520 mce related protein; Region: MCE; pfam02470 1156913006521 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913006522 mce related protein; Region: MCE; pfam02470 1156913006523 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1156913006524 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913006525 mce related protein; Region: MCE; pfam02470 1156913006526 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1156913006527 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913006528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913006529 homodimer interface [polypeptide binding]; other site 1156913006530 catalytic residue [active] 1156913006531 Ferritin-like domain; Region: Ferritin_2; pfam13668 1156913006532 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1156913006533 hypothetical protein; Provisional; Region: PRK07236 1156913006534 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1156913006535 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1156913006536 acyl-activating enzyme (AAE) consensus motif; other site 1156913006537 putative AMP binding site [chemical binding]; other site 1156913006538 putative active site [active] 1156913006539 putative CoA binding site [chemical binding]; other site 1156913006540 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913006541 active site 1156913006542 metal binding site [ion binding]; metal-binding site 1156913006543 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1156913006544 putative hydrophobic ligand binding site [chemical binding]; other site 1156913006545 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1156913006546 DTAP/Switch II; other site 1156913006547 Switch I; other site 1156913006548 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1156913006549 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1156913006550 nucleotide binding site [chemical binding]; other site 1156913006551 NUDIX domain; Region: NUDIX; pfam00293 1156913006552 nudix motif; other site 1156913006553 carboxylate-amine ligase; Provisional; Region: PRK13517 1156913006554 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1156913006555 Esterase/lipase [General function prediction only]; Region: COG1647 1156913006556 Serine hydrolase; Region: Ser_hydrolase; cl17834 1156913006557 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1156913006558 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1156913006559 putative acyl-acceptor binding pocket; other site 1156913006560 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1156913006561 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1156913006562 phosphofructokinase; Region: PFK_mixed; TIGR02483 1156913006563 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1156913006564 active site 1156913006565 ADP/pyrophosphate binding site [chemical binding]; other site 1156913006566 dimerization interface [polypeptide binding]; other site 1156913006567 allosteric effector site; other site 1156913006568 fructose-1,6-bisphosphate binding site; other site 1156913006569 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913006570 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913006571 active site 1156913006572 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1156913006573 active sites [active] 1156913006574 tetramer interface [polypeptide binding]; other site 1156913006575 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1156913006576 apolar tunnel; other site 1156913006577 heme binding site [chemical binding]; other site 1156913006578 dimerization interface [polypeptide binding]; other site 1156913006579 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913006580 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913006581 dimerization interface [polypeptide binding]; other site 1156913006582 putative DNA binding site [nucleotide binding]; other site 1156913006583 putative Zn2+ binding site [ion binding]; other site 1156913006584 Glyco_18 domain; Region: Glyco_18; smart00636 1156913006585 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1156913006586 active site 1156913006587 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 1156913006588 pyruvate kinase; Provisional; Region: PRK06247 1156913006589 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1156913006590 active site 1156913006591 domain interfaces; other site 1156913006592 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1156913006593 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1156913006594 active site 1156913006595 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1156913006596 catalytic triad [active] 1156913006597 dimer interface [polypeptide binding]; other site 1156913006598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913006599 sequence-specific DNA binding site [nucleotide binding]; other site 1156913006600 salt bridge; other site 1156913006601 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1156913006602 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913006603 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913006604 DNA binding residues [nucleotide binding] 1156913006605 dimerization interface [polypeptide binding]; other site 1156913006606 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1156913006607 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1156913006608 NAD(P) binding site [chemical binding]; other site 1156913006609 catalytic residues [active] 1156913006610 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1156913006611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913006612 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006613 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913006614 active site 1156913006615 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1156913006616 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1156913006617 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1156913006618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1156913006619 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1156913006620 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913006621 substrate binding site [chemical binding]; other site 1156913006622 oxyanion hole (OAH) forming residues; other site 1156913006623 trimer interface [polypeptide binding]; other site 1156913006624 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1156913006625 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1156913006626 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1156913006627 integral membrane protein; Region: integ_memb_HG; TIGR03954 1156913006628 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913006629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913006630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913006631 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1156913006632 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1156913006633 Na binding site [ion binding]; other site 1156913006634 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1156913006635 Nitrate and nitrite sensing; Region: NIT; pfam08376 1156913006636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913006637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913006638 ATP binding site [chemical binding]; other site 1156913006639 Mg2+ binding site [ion binding]; other site 1156913006640 G-X-G motif; other site 1156913006641 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1156913006642 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1156913006643 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1156913006644 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1156913006645 G1 box; other site 1156913006646 GTP/Mg2+ binding site [chemical binding]; other site 1156913006647 G2 box; other site 1156913006648 Switch I region; other site 1156913006649 G3 box; other site 1156913006650 Switch II region; other site 1156913006651 G4 box; other site 1156913006652 G5 box; other site 1156913006653 RibD C-terminal domain; Region: RibD_C; cl17279 1156913006654 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 1156913006655 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1156913006656 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913006657 dimerization interface [polypeptide binding]; other site 1156913006658 putative DNA binding site [nucleotide binding]; other site 1156913006659 putative Zn2+ binding site [ion binding]; other site 1156913006660 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1156913006661 B12 binding site [chemical binding]; other site 1156913006662 cobalt ligand [ion binding]; other site 1156913006663 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1156913006664 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1156913006665 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1156913006666 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1156913006667 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913006668 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 1156913006669 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913006670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913006671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913006672 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1156913006673 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006674 active site 1156913006675 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913006676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006677 active site 1156913006678 SNF2 Helicase protein; Region: DUF3670; pfam12419 1156913006679 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1156913006680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913006681 ATP binding site [chemical binding]; other site 1156913006682 putative Mg++ binding site [ion binding]; other site 1156913006683 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1156913006684 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913006685 nucleotide binding region [chemical binding]; other site 1156913006686 ATP-binding site [chemical binding]; other site 1156913006687 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1156913006688 SWIM zinc finger; Region: SWIM; pfam04434 1156913006689 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1156913006690 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1156913006691 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913006692 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1156913006693 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1156913006694 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006695 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1156913006696 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913006697 active site 1156913006698 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006699 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913006700 active site 1156913006701 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1156913006702 active site 1156913006703 catalytic site [active] 1156913006704 DUF35 OB-fold domain; Region: DUF35; pfam01796 1156913006705 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1156913006706 putative active site [active] 1156913006707 putative catalytic site [active] 1156913006708 lipid-transfer protein; Provisional; Region: PRK07855 1156913006709 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1156913006710 active site 1156913006711 Riboflavin kinase; Region: Flavokinase; smart00904 1156913006712 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1156913006713 enoyl-CoA hydratase; Region: PLN02864 1156913006714 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1156913006715 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1156913006716 dimer interaction site [polypeptide binding]; other site 1156913006717 substrate-binding tunnel; other site 1156913006718 active site 1156913006719 catalytic site [active] 1156913006720 substrate binding site [chemical binding]; other site 1156913006721 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1156913006722 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1156913006723 FAD binding pocket [chemical binding]; other site 1156913006724 FAD binding motif [chemical binding]; other site 1156913006725 phosphate binding motif [ion binding]; other site 1156913006726 beta-alpha-beta structure motif; other site 1156913006727 NAD(p) ribose binding residues [chemical binding]; other site 1156913006728 NAD binding pocket [chemical binding]; other site 1156913006729 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1156913006730 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913006731 catalytic loop [active] 1156913006732 iron binding site [ion binding]; other site 1156913006733 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1156913006734 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1156913006735 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1156913006736 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1156913006737 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1156913006738 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1156913006739 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006740 Flavin binding site [chemical binding]; other site 1156913006741 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1156913006742 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913006743 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1156913006744 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1156913006745 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1156913006746 active site 1156913006747 Fe binding site [ion binding]; other site 1156913006748 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1156913006749 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1156913006750 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1156913006751 calcium binding site 2 [ion binding]; other site 1156913006752 active site 1156913006753 catalytic triad [active] 1156913006754 calcium binding site 1 [ion binding]; other site 1156913006755 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1156913006756 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1156913006757 putative di-iron ligands [ion binding]; other site 1156913006758 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913006759 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913006760 active site 1156913006761 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913006762 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1156913006763 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913006764 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913006765 DNA binding residues [nucleotide binding] 1156913006766 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1156913006767 nucleotide binding site/active site [active] 1156913006768 HIT family signature motif; other site 1156913006769 catalytic residue [active] 1156913006770 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1156913006771 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913006772 active site 1156913006773 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006774 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1156913006775 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913006776 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006777 active site 1156913006778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913006780 active site 1156913006781 enoyl-CoA hydratase; Provisional; Region: PRK08290 1156913006782 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913006783 substrate binding site [chemical binding]; other site 1156913006784 oxyanion hole (OAH) forming residues; other site 1156913006785 trimer interface [polypeptide binding]; other site 1156913006786 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1156913006787 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913006788 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1156913006789 acyl-activating enzyme (AAE) consensus motif; other site 1156913006790 putative AMP binding site [chemical binding]; other site 1156913006791 putative active site [active] 1156913006792 putative CoA binding site [chemical binding]; other site 1156913006793 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913006794 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913006795 active site 1156913006796 short chain dehydrogenase; Provisional; Region: PRK07831 1156913006797 classical (c) SDRs; Region: SDR_c; cd05233 1156913006798 NAD(P) binding site [chemical binding]; other site 1156913006799 active site 1156913006800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913006801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913006802 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1156913006803 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1156913006804 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1156913006805 dimer interface [polypeptide binding]; other site 1156913006806 active site 1156913006807 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1156913006808 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913006809 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913006810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1156913006811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913006812 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1156913006813 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1156913006814 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1156913006815 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1156913006816 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1156913006817 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1156913006818 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913006819 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913006820 DNA binding residues [nucleotide binding] 1156913006821 Putative zinc-finger; Region: zf-HC2; pfam13490 1156913006822 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1156913006823 maltose O-acetyltransferase; Provisional; Region: PRK10092 1156913006824 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1156913006825 active site 1156913006826 substrate binding site [chemical binding]; other site 1156913006827 trimer interface [polypeptide binding]; other site 1156913006828 CoA binding site [chemical binding]; other site 1156913006829 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913006830 putative DNA binding site [nucleotide binding]; other site 1156913006831 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1156913006832 putative Zn2+ binding site [ion binding]; other site 1156913006833 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913006834 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 1156913006835 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913006836 Nitronate monooxygenase; Region: NMO; pfam03060 1156913006837 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1156913006838 FMN binding site [chemical binding]; other site 1156913006839 substrate binding site [chemical binding]; other site 1156913006840 putative catalytic residue [active] 1156913006841 Coenzyme A transferase; Region: CoA_trans; cl17247 1156913006842 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1156913006843 enoyl-CoA hydratase; Provisional; Region: PRK06495 1156913006844 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913006845 substrate binding site [chemical binding]; other site 1156913006846 oxyanion hole (OAH) forming residues; other site 1156913006847 trimer interface [polypeptide binding]; other site 1156913006848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913006849 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1156913006850 NAD(P) binding site [chemical binding]; other site 1156913006851 active site 1156913006852 short chain dehydrogenase; Provisional; Region: PRK07791 1156913006853 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1156913006854 homodimer interface [polypeptide binding]; other site 1156913006855 NAD binding site [chemical binding]; other site 1156913006856 active site 1156913006857 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1156913006858 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1156913006859 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1156913006860 dimer interface [polypeptide binding]; other site 1156913006861 active site 1156913006862 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913006863 Cytochrome P450; Region: p450; cl12078 1156913006864 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1156913006865 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1156913006866 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1156913006867 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1156913006868 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1156913006869 active site 1156913006870 lipid-transfer protein; Provisional; Region: PRK07937 1156913006871 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1156913006872 active site 1156913006873 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1156913006874 DUF35 OB-fold domain; Region: DUF35; pfam01796 1156913006875 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1156913006876 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1156913006877 DUF35 OB-fold domain; Region: DUF35; pfam01796 1156913006878 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913006879 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1156913006880 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1156913006881 acyl-activating enzyme (AAE) consensus motif; other site 1156913006882 putative AMP binding site [chemical binding]; other site 1156913006883 putative active site [active] 1156913006884 putative CoA binding site [chemical binding]; other site 1156913006885 enoyl-CoA hydratase; Provisional; Region: PRK07799 1156913006886 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913006887 substrate binding site [chemical binding]; other site 1156913006888 oxyanion hole (OAH) forming residues; other site 1156913006889 trimer interface [polypeptide binding]; other site 1156913006890 acyl-CoA synthetase; Validated; Region: PRK07798 1156913006891 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913006892 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1156913006893 acyl-activating enzyme (AAE) consensus motif; other site 1156913006894 acyl-activating enzyme (AAE) consensus motif; other site 1156913006895 putative AMP binding site [chemical binding]; other site 1156913006896 putative active site [active] 1156913006897 putative CoA binding site [chemical binding]; other site 1156913006898 Nitronate monooxygenase; Region: NMO; pfam03060 1156913006899 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1156913006900 FMN binding site [chemical binding]; other site 1156913006901 substrate binding site [chemical binding]; other site 1156913006902 putative catalytic residue [active] 1156913006903 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1156913006904 cleavage site 1156913006905 active site 1156913006906 substrate binding sites [chemical binding]; other site 1156913006907 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1156913006908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913006909 DNA-binding site [nucleotide binding]; DNA binding site 1156913006910 UTRA domain; Region: UTRA; pfam07702 1156913006911 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 1156913006912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913006913 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 1156913006914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913006915 motif II; other site 1156913006916 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1156913006917 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1156913006918 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1156913006919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913006920 Walker A/P-loop; other site 1156913006921 ATP binding site [chemical binding]; other site 1156913006922 Q-loop/lid; other site 1156913006923 ABC transporter signature motif; other site 1156913006924 Walker B; other site 1156913006925 D-loop; other site 1156913006926 H-loop/switch region; other site 1156913006927 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1156913006928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913006929 dimer interface [polypeptide binding]; other site 1156913006930 conserved gate region; other site 1156913006931 putative PBP binding loops; other site 1156913006932 ABC-ATPase subunit interface; other site 1156913006933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1156913006934 fumarate hydratase; Provisional; Region: PRK15389 1156913006935 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1156913006936 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1156913006937 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1156913006938 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1156913006939 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913006940 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1156913006941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913006942 DNA binding residues [nucleotide binding] 1156913006943 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1156913006944 putative active site [active] 1156913006945 dimerization interface [polypeptide binding]; other site 1156913006946 putative tRNAtyr binding site [nucleotide binding]; other site 1156913006947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913006948 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1156913006949 S-adenosylmethionine binding site [chemical binding]; other site 1156913006950 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1156913006951 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1156913006952 metal binding site [ion binding]; metal-binding site 1156913006953 putative dimer interface [polypeptide binding]; other site 1156913006954 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1156913006955 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1156913006956 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1156913006957 substrate binding site [chemical binding]; other site 1156913006958 ATP binding site [chemical binding]; other site 1156913006959 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1156913006960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1156913006961 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1156913006962 SpoOM protein; Region: Spo0M; pfam07070 1156913006963 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1156913006964 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1156913006965 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1156913006966 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1156913006967 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913006968 ATP binding site [chemical binding]; other site 1156913006969 putative Mg++ binding site [ion binding]; other site 1156913006970 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1156913006971 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1156913006972 putative ligand binding site [chemical binding]; other site 1156913006973 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1156913006974 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1156913006975 Walker A/P-loop; other site 1156913006976 ATP binding site [chemical binding]; other site 1156913006977 Q-loop/lid; other site 1156913006978 ABC transporter signature motif; other site 1156913006979 Walker B; other site 1156913006980 D-loop; other site 1156913006981 H-loop/switch region; other site 1156913006982 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913006983 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913006984 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913006985 TM-ABC transporter signature motif; other site 1156913006986 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1156913006987 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1156913006988 nucleotide binding site [chemical binding]; other site 1156913006989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913006990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913006991 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913006992 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1156913006993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1156913006994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913006995 Coenzyme A binding pocket [chemical binding]; other site 1156913006996 amino acid transporter; Region: 2A0306; TIGR00909 1156913006997 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1156913006998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913006999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913007000 active site 1156913007001 phosphorylation site [posttranslational modification] 1156913007002 intermolecular recognition site; other site 1156913007003 dimerization interface [polypeptide binding]; other site 1156913007004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913007005 DNA binding residues [nucleotide binding] 1156913007006 dimerization interface [polypeptide binding]; other site 1156913007007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913007008 Histidine kinase; Region: HisKA_3; pfam07730 1156913007009 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913007010 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913007011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913007012 S-adenosylmethionine binding site [chemical binding]; other site 1156913007013 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1156913007014 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1156913007015 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913007016 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1156913007017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913007018 DNA binding residues [nucleotide binding] 1156913007019 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913007020 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1156913007021 nucleotide binding site [chemical binding]; other site 1156913007022 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1156913007023 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1156913007024 active site 1156913007025 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1156913007026 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1156913007027 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1156913007028 trimer interface [polypeptide binding]; other site 1156913007029 active site 1156913007030 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1156913007031 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1156913007032 generic binding surface II; other site 1156913007033 ssDNA binding site; other site 1156913007034 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1156913007035 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1156913007036 TrkA-N domain; Region: TrkA_N; pfam02254 1156913007037 TrkA-C domain; Region: TrkA_C; pfam02080 1156913007038 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1156913007039 TrkA-N domain; Region: TrkA_N; pfam02254 1156913007040 TrkA-C domain; Region: TrkA_C; pfam02080 1156913007041 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1156913007042 TRAM domain; Region: TRAM; pfam01938 1156913007043 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1156913007044 Protein of unknown function (DUF1062); Region: DUF1062; pfam06353 1156913007045 choline dehydrogenase; Validated; Region: PRK02106 1156913007046 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1156913007047 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 1156913007048 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913007049 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913007050 NAD(P) binding site [chemical binding]; other site 1156913007051 catalytic residues [active] 1156913007052 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1156913007053 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1156913007054 TPP-binding site; other site 1156913007055 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1156913007056 PYR/PP interface [polypeptide binding]; other site 1156913007057 dimer interface [polypeptide binding]; other site 1156913007058 TPP binding site [chemical binding]; other site 1156913007059 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1156913007060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913007061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913007062 short chain dehydrogenase; Validated; Region: PRK06182 1156913007063 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1156913007064 NADP binding site [chemical binding]; other site 1156913007065 active site 1156913007066 steroid binding site; other site 1156913007067 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1156913007068 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1156913007069 Na binding site [ion binding]; other site 1156913007070 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1156913007071 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1156913007072 tetrameric interface [polypeptide binding]; other site 1156913007073 NAD binding site [chemical binding]; other site 1156913007074 catalytic residues [active] 1156913007075 substrate binding site [chemical binding]; other site 1156913007076 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1156913007077 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1156913007078 PYR/PP interface [polypeptide binding]; other site 1156913007079 dimer interface [polypeptide binding]; other site 1156913007080 TPP binding site [chemical binding]; other site 1156913007081 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1156913007082 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1156913007083 TPP-binding site [chemical binding]; other site 1156913007084 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1156913007085 agmatinase; Region: agmatinase; TIGR01230 1156913007086 oligomer interface [polypeptide binding]; other site 1156913007087 putative active site [active] 1156913007088 Mn binding site [ion binding]; other site 1156913007089 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 1156913007090 Na binding site [ion binding]; other site 1156913007091 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1156913007092 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913007093 Homeodomain-like domain; Region: HTH_23; cl17451 1156913007094 Winged helix-turn helix; Region: HTH_29; pfam13551 1156913007095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1156913007096 Integrase core domain; Region: rve; pfam00665 1156913007097 Integrase core domain; Region: rve_3; pfam13683 1156913007098 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1156913007099 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913007100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913007101 active site 1156913007102 phosphorylation site [posttranslational modification] 1156913007103 intermolecular recognition site; other site 1156913007104 dimerization interface [polypeptide binding]; other site 1156913007105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913007106 DNA binding site [nucleotide binding] 1156913007107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913007108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913007109 dimerization interface [polypeptide binding]; other site 1156913007110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913007111 dimer interface [polypeptide binding]; other site 1156913007112 phosphorylation site [posttranslational modification] 1156913007113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913007114 ATP binding site [chemical binding]; other site 1156913007115 Mg2+ binding site [ion binding]; other site 1156913007116 G-X-G motif; other site 1156913007117 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913007118 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913007119 active site 1156913007120 catalytic tetrad [active] 1156913007121 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1156913007122 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1156913007123 active site 1156913007124 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1156913007125 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913007126 substrate binding site [chemical binding]; other site 1156913007127 oxyanion hole (OAH) forming residues; other site 1156913007128 trimer interface [polypeptide binding]; other site 1156913007129 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1156913007130 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1156913007131 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1156913007132 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1156913007133 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1156913007134 dimer interface [polypeptide binding]; other site 1156913007135 active site 1156913007136 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1156913007137 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1156913007138 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1156913007139 allophanate hydrolase; Provisional; Region: PRK08186 1156913007140 Amidase; Region: Amidase; cl11426 1156913007141 urea carboxylase; Region: urea_carbox; TIGR02712 1156913007142 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1156913007143 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1156913007144 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1156913007145 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1156913007146 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1156913007147 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1156913007148 carboxyltransferase (CT) interaction site; other site 1156913007149 biotinylation site [posttranslational modification]; other site 1156913007150 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1156913007151 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1156913007152 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1156913007153 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1156913007154 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 1156913007155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913007156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913007157 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1156913007158 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1156913007159 catalytic site [active] 1156913007160 putative active site [active] 1156913007161 putative substrate binding site [chemical binding]; other site 1156913007162 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1156913007163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913007164 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913007165 active site 1156913007166 phosphorylation site [posttranslational modification] 1156913007167 intermolecular recognition site; other site 1156913007168 dimerization interface [polypeptide binding]; other site 1156913007169 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913007170 DNA binding residues [nucleotide binding] 1156913007171 dimerization interface [polypeptide binding]; other site 1156913007172 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1156913007173 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1156913007174 substrate binding site [chemical binding]; other site 1156913007175 active site 1156913007176 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1156913007177 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913007178 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1156913007179 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1156913007180 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1156913007181 TIGR04222 domain; Region: near_uncomplex 1156913007182 TIGR04222 domain; Region: near_uncomplex 1156913007183 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1156913007184 SelR domain; Region: SelR; pfam01641 1156913007185 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913007186 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913007187 active site 1156913007188 ATP binding site [chemical binding]; other site 1156913007189 substrate binding site [chemical binding]; other site 1156913007190 activation loop (A-loop); other site 1156913007191 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1156913007192 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1156913007193 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913007194 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913007195 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1156913007196 nucleotide binding site [chemical binding]; other site 1156913007197 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1156913007198 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913007199 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1156913007200 RNA binding site [nucleotide binding]; other site 1156913007201 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913007202 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1156913007203 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1156913007204 Glutamate binding site [chemical binding]; other site 1156913007205 NAD binding site [chemical binding]; other site 1156913007206 catalytic residues [active] 1156913007207 Proline dehydrogenase; Region: Pro_dh; cl03282 1156913007208 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1156913007209 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1156913007210 catalytic residues [active] 1156913007211 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1156913007212 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913007213 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1156913007214 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1156913007215 active site 1156913007216 DNA binding site [nucleotide binding] 1156913007217 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1156913007218 DNA binding site [nucleotide binding] 1156913007219 Asp23 family; Region: Asp23; pfam03780 1156913007220 Asp23 family; Region: Asp23; pfam03780 1156913007221 Asp23 family; Region: Asp23; cl00574 1156913007222 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913007223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913007224 hypothetical protein; Provisional; Region: PRK14059 1156913007225 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1156913007226 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1156913007227 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1156913007228 active site 1156913007229 FAD dependent oxidoreductase; Region: DAO; pfam01266 1156913007230 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1156913007231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1156913007232 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1156913007233 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913007234 inhibitor-cofactor binding pocket; inhibition site 1156913007235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913007236 catalytic residue [active] 1156913007237 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1156913007238 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1156913007239 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913007240 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913007241 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1156913007242 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913007243 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1156913007244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913007245 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913007246 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913007247 MarR family; Region: MarR_2; pfam12802 1156913007248 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1156913007249 CrcB-like protein; Region: CRCB; pfam02537 1156913007250 Cupin superfamily protein; Region: Cupin_4; pfam08007 1156913007251 Cupin-like domain; Region: Cupin_8; pfam13621 1156913007252 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1156913007253 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1156913007254 protein-splicing catalytic site; other site 1156913007255 thioester formation/cholesterol transfer; other site 1156913007256 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1156913007257 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913007258 FeS/SAM binding site; other site 1156913007259 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1156913007260 Alkylmercury lyase; Region: MerB; pfam03243 1156913007261 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1156913007262 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1156913007263 dimer interface [polypeptide binding]; other site 1156913007264 anticodon binding site; other site 1156913007265 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1156913007266 homodimer interface [polypeptide binding]; other site 1156913007267 motif 1; other site 1156913007268 active site 1156913007269 motif 2; other site 1156913007270 GAD domain; Region: GAD; pfam02938 1156913007271 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1156913007272 active site 1156913007273 motif 3; other site 1156913007274 Domain of unknown function (DUF389); Region: DUF389; cl00781 1156913007275 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1156913007276 active site 1156913007277 catalytic triad [active] 1156913007278 oxyanion hole [active] 1156913007279 recombination factor protein RarA; Reviewed; Region: PRK13342 1156913007280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913007281 Walker A motif; other site 1156913007282 ATP binding site [chemical binding]; other site 1156913007283 Walker B motif; other site 1156913007284 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1156913007285 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913007286 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913007287 active site 1156913007288 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913007289 active site 1156913007290 metal binding site [ion binding]; metal-binding site 1156913007291 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1156913007292 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1156913007293 ligand binding site [chemical binding]; other site 1156913007294 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1156913007295 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1156913007296 Walker A/P-loop; other site 1156913007297 ATP binding site [chemical binding]; other site 1156913007298 Q-loop/lid; other site 1156913007299 ABC transporter signature motif; other site 1156913007300 Walker B; other site 1156913007301 D-loop; other site 1156913007302 H-loop/switch region; other site 1156913007303 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1156913007304 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913007305 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1156913007306 TM-ABC transporter signature motif; other site 1156913007307 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913007308 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1156913007309 TM-ABC transporter signature motif; other site 1156913007310 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1156913007311 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1156913007312 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1156913007313 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913007314 active site 1156913007315 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1156913007316 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1156913007317 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 1156913007318 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1156913007319 intersubunit interface [polypeptide binding]; other site 1156913007320 active site 1156913007321 Zn2+ binding site [ion binding]; other site 1156913007322 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1156913007323 Cupin domain; Region: Cupin_2; cl17218 1156913007324 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1156913007325 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1156913007326 active site 1156913007327 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1156913007328 Chitinase C; Region: ChiC; pfam06483 1156913007329 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1156913007330 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1156913007331 active site 1156913007332 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1156913007333 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1156913007334 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1156913007335 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1156913007336 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1156913007337 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1156913007338 DXD motif; other site 1156913007339 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1156913007340 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1156913007341 motif 1; other site 1156913007342 active site 1156913007343 motif 2; other site 1156913007344 motif 3; other site 1156913007345 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1156913007346 DHHA1 domain; Region: DHHA1; pfam02272 1156913007347 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1156913007348 YceG-like family; Region: YceG; pfam02618 1156913007349 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1156913007350 dimerization interface [polypeptide binding]; other site 1156913007351 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1156913007352 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1156913007353 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1156913007354 NAD(P) binding site [chemical binding]; other site 1156913007355 shikimate binding site; other site 1156913007356 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1156913007357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913007358 S-adenosylmethionine binding site [chemical binding]; other site 1156913007359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913007360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913007361 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913007362 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1156913007363 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1156913007364 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1156913007365 dimerization interface [polypeptide binding]; other site 1156913007366 NAD binding site [chemical binding]; other site 1156913007367 ligand binding site [chemical binding]; other site 1156913007368 catalytic site [active] 1156913007369 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913007370 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913007371 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913007372 CoA binding site [chemical binding]; other site 1156913007373 active site 1156913007374 AMP binding site [chemical binding]; other site 1156913007375 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913007376 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1156913007377 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1156913007378 Walker A/P-loop; other site 1156913007379 ATP binding site [chemical binding]; other site 1156913007380 Q-loop/lid; other site 1156913007381 ABC transporter signature motif; other site 1156913007382 Walker B; other site 1156913007383 D-loop; other site 1156913007384 H-loop/switch region; other site 1156913007385 TOBE domain; Region: TOBE_2; pfam08402 1156913007386 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1156913007387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913007388 dimer interface [polypeptide binding]; other site 1156913007389 conserved gate region; other site 1156913007390 putative PBP binding loops; other site 1156913007391 ABC-ATPase subunit interface; other site 1156913007392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913007393 dimer interface [polypeptide binding]; other site 1156913007394 conserved gate region; other site 1156913007395 ABC-ATPase subunit interface; other site 1156913007396 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1156913007397 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1156913007398 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913007399 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913007400 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 1156913007401 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1156913007402 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1156913007403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913007404 DNA-binding site [nucleotide binding]; DNA binding site 1156913007405 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1156913007406 phosphotransferase system, EIIB; Region: PTS_EIIB; pfam00367 1156913007407 active site turn [active] 1156913007408 phosphorylation site [posttranslational modification] 1156913007409 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1156913007410 HPr interaction site; other site 1156913007411 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1156913007412 active site 1156913007413 phosphorylation site [posttranslational modification] 1156913007414 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1156913007415 iron-sulfur cluster [ion binding]; other site 1156913007416 [2Fe-2S] cluster binding site [ion binding]; other site 1156913007417 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1156913007418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913007419 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913007420 DNA binding residues [nucleotide binding] 1156913007421 Putative zinc-finger; Region: zf-HC2; pfam13490 1156913007422 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1156913007423 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1156913007424 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1156913007425 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1156913007426 Tetramer interface [polypeptide binding]; other site 1156913007427 active site 1156913007428 FMN-binding site [chemical binding]; other site 1156913007429 shikimate kinase; Reviewed; Region: aroK; PRK00131 1156913007430 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1156913007431 ADP binding site [chemical binding]; other site 1156913007432 magnesium binding site [ion binding]; other site 1156913007433 putative shikimate binding site; other site 1156913007434 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1156913007435 active site 1156913007436 dimer interface [polypeptide binding]; other site 1156913007437 metal binding site [ion binding]; metal-binding site 1156913007438 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1156913007439 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1156913007440 active site 1156913007441 trimer interface [polypeptide binding]; other site 1156913007442 dimer interface [polypeptide binding]; other site 1156913007443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913007444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913007445 Coenzyme A binding pocket [chemical binding]; other site 1156913007446 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913007447 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1156913007448 putative dimer interface [polypeptide binding]; other site 1156913007449 ligand binding site [chemical binding]; other site 1156913007450 Zn binding site [ion binding]; other site 1156913007451 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1156913007452 active site 1156913007453 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1156913007454 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1156913007455 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1156913007456 active site 1156913007457 elongation factor P; Validated; Region: PRK00529 1156913007458 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1156913007459 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1156913007460 RNA binding site [nucleotide binding]; other site 1156913007461 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1156913007462 RNA binding site [nucleotide binding]; other site 1156913007463 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1156913007464 putative RNA binding site [nucleotide binding]; other site 1156913007465 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913007466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913007467 non-specific DNA binding site [nucleotide binding]; other site 1156913007468 salt bridge; other site 1156913007469 sequence-specific DNA binding site [nucleotide binding]; other site 1156913007470 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1156913007471 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1156913007472 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1156913007473 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1156913007474 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1156913007475 dihydroorotase; Validated; Region: pyrC; PRK09357 1156913007476 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913007477 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1156913007478 active site 1156913007479 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1156913007480 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1156913007481 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1156913007482 catalytic site [active] 1156913007483 subunit interface [polypeptide binding]; other site 1156913007484 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1156913007485 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1156913007486 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1156913007487 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1156913007488 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1156913007489 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1156913007490 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1156913007491 IMP binding site; other site 1156913007492 dimer interface [polypeptide binding]; other site 1156913007493 interdomain contacts; other site 1156913007494 partial ornithine binding site; other site 1156913007495 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1156913007496 active site 1156913007497 dimer interface [polypeptide binding]; other site 1156913007498 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1156913007499 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1156913007500 catalytic site [active] 1156913007501 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1156913007502 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1156913007503 Flavoprotein; Region: Flavoprotein; pfam02441 1156913007504 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1156913007505 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1156913007506 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1156913007507 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1156913007508 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1156913007509 primosome assembly protein PriA; Provisional; Region: PRK14873 1156913007510 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 1156913007511 putative substrate binding pocket [chemical binding]; other site 1156913007512 AB domain interface; other site 1156913007513 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1156913007514 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1156913007515 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1156913007516 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1156913007517 putative active site [active] 1156913007518 substrate binding site [chemical binding]; other site 1156913007519 putative cosubstrate binding site; other site 1156913007520 catalytic site [active] 1156913007521 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1156913007522 substrate binding site [chemical binding]; other site 1156913007523 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1156913007524 putative RNA binding site [nucleotide binding]; other site 1156913007525 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1156913007526 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1156913007527 Flavoprotein; Region: Flavoprotein; cl08021 1156913007528 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913007529 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913007530 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913007531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913007532 active site 1156913007533 phosphorylation site [posttranslational modification] 1156913007534 intermolecular recognition site; other site 1156913007535 dimerization interface [polypeptide binding]; other site 1156913007536 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913007537 DNA binding residues [nucleotide binding] 1156913007538 dimerization interface [polypeptide binding]; other site 1156913007539 Histidine kinase; Region: HisKA_3; pfam07730 1156913007540 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913007541 Mg2+ binding site [ion binding]; other site 1156913007542 G-X-G motif; other site 1156913007543 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1156913007544 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1156913007545 substrate binding site [chemical binding]; other site 1156913007546 hexamer interface [polypeptide binding]; other site 1156913007547 metal binding site [ion binding]; metal-binding site 1156913007548 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1156913007549 Lumazine binding domain; Region: Lum_binding; pfam00677 1156913007550 Lumazine binding domain; Region: Lum_binding; pfam00677 1156913007551 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1156913007552 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1156913007553 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1156913007554 dimerization interface [polypeptide binding]; other site 1156913007555 active site 1156913007556 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1156913007557 homopentamer interface [polypeptide binding]; other site 1156913007558 active site 1156913007559 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1156913007560 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1156913007561 putative catalytic site [active] 1156913007562 putative phosphate binding site [ion binding]; other site 1156913007563 active site 1156913007564 metal binding site A [ion binding]; metal-binding site 1156913007565 DNA binding site [nucleotide binding] 1156913007566 putative AP binding site [nucleotide binding]; other site 1156913007567 putative metal binding site B [ion binding]; other site 1156913007568 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913007569 cleavage site 1156913007570 active site 1156913007571 substrate binding sites [chemical binding]; other site 1156913007572 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1156913007573 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1156913007574 active site 1156913007575 GIY-YIG motif/motif A; other site 1156913007576 catalytic site [active] 1156913007577 putative DNA binding site [nucleotide binding]; other site 1156913007578 metal binding site [ion binding]; metal-binding site 1156913007579 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1156913007580 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1156913007581 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1156913007582 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1156913007583 dimer interface [polypeptide binding]; other site 1156913007584 phosphate binding site [ion binding]; other site 1156913007585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1156913007586 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1156913007587 AAA domain; Region: AAA_22; pfam13401 1156913007588 AAA ATPase domain; Region: AAA_16; pfam13191 1156913007589 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1156913007590 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1156913007591 phosphopeptide binding site; other site 1156913007592 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1156913007593 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1156913007594 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1156913007595 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1156913007596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913007597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913007598 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 1156913007599 Ca binding site [ion binding]; other site 1156913007600 Ca binding site (active) [ion binding]; other site 1156913007601 ligand binding site [chemical binding]; other site 1156913007602 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913007603 Interdomain contacts; other site 1156913007604 Cytokine receptor motif; other site 1156913007605 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913007606 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1156913007607 Interdomain contacts; other site 1156913007608 Cytokine receptor motif; other site 1156913007609 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1156913007610 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1156913007611 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1156913007612 substrate binding site [chemical binding]; other site 1156913007613 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1156913007614 Cupin; Region: Cupin_6; pfam12852 1156913007615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913007616 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913007617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913007618 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1156913007619 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1156913007620 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1156913007621 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1156913007622 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1156913007623 Phosphoglycerate kinase; Region: PGK; pfam00162 1156913007624 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1156913007625 substrate binding site [chemical binding]; other site 1156913007626 hinge regions; other site 1156913007627 ADP binding site [chemical binding]; other site 1156913007628 catalytic site [active] 1156913007629 triosephosphate isomerase; Provisional; Region: PRK14567 1156913007630 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1156913007631 substrate binding site [chemical binding]; other site 1156913007632 dimer interface [polypeptide binding]; other site 1156913007633 catalytic triad [active] 1156913007634 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1156913007635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913007636 Histidine kinase; Region: HisKA_3; pfam07730 1156913007637 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913007638 ATP binding site [chemical binding]; other site 1156913007639 Mg2+ binding site [ion binding]; other site 1156913007640 G-X-G motif; other site 1156913007641 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1156913007642 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1156913007643 putative active site [active] 1156913007644 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1156913007645 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1156913007646 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1156913007647 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1156913007648 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1156913007649 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 1156913007650 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1156913007651 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1156913007652 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1156913007653 putative active site [active] 1156913007654 transaldolase; Provisional; Region: PRK03903 1156913007655 catalytic residue [active] 1156913007656 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1156913007657 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1156913007658 TPP-binding site [chemical binding]; other site 1156913007659 dimer interface [polypeptide binding]; other site 1156913007660 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1156913007661 PYR/PP interface [polypeptide binding]; other site 1156913007662 dimer interface [polypeptide binding]; other site 1156913007663 TPP binding site [chemical binding]; other site 1156913007664 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1156913007665 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1156913007666 UbiA prenyltransferase family; Region: UbiA; pfam01040 1156913007667 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1156913007668 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1156913007669 Part of AAA domain; Region: AAA_19; pfam13245 1156913007670 Family description; Region: UvrD_C_2; pfam13538 1156913007671 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1156913007672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913007673 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913007674 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1156913007675 Enoylreductase; Region: PKS_ER; smart00829 1156913007676 NADP binding site [chemical binding]; other site 1156913007677 dimer interface [polypeptide binding]; other site 1156913007678 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1156913007679 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1156913007680 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1156913007681 Di-iron ligands [ion binding]; other site 1156913007682 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1156913007683 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1156913007684 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1156913007685 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913007686 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913007687 Walker A/P-loop; other site 1156913007688 ATP binding site [chemical binding]; other site 1156913007689 Q-loop/lid; other site 1156913007690 ABC transporter signature motif; other site 1156913007691 Walker B; other site 1156913007692 D-loop; other site 1156913007693 H-loop/switch region; other site 1156913007694 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1156913007695 Predicted transcriptional regulator [Transcription]; Region: COG2345 1156913007696 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913007697 putative DNA binding site [nucleotide binding]; other site 1156913007698 putative Zn2+ binding site [ion binding]; other site 1156913007699 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1156913007700 FeS assembly protein SufB; Region: sufB; TIGR01980 1156913007701 FeS assembly protein SufD; Region: sufD; TIGR01981 1156913007702 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1156913007703 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1156913007704 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1156913007705 Walker A/P-loop; other site 1156913007706 ATP binding site [chemical binding]; other site 1156913007707 Q-loop/lid; other site 1156913007708 ABC transporter signature motif; other site 1156913007709 Walker B; other site 1156913007710 D-loop; other site 1156913007711 H-loop/switch region; other site 1156913007712 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1156913007713 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1156913007714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913007715 catalytic residue [active] 1156913007716 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1156913007717 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1156913007718 trimerization site [polypeptide binding]; other site 1156913007719 active site 1156913007720 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1156913007721 hypothetical protein; Provisional; Region: PRK02237 1156913007722 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1156913007723 ABC1 family; Region: ABC1; cl17513 1156913007724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913007725 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913007726 Histidine kinase; Region: HisKA_3; pfam07730 1156913007727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913007728 ATP binding site [chemical binding]; other site 1156913007729 Mg2+ binding site [ion binding]; other site 1156913007730 G-X-G motif; other site 1156913007731 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913007732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913007733 active site 1156913007734 phosphorylation site [posttranslational modification] 1156913007735 intermolecular recognition site; other site 1156913007736 dimerization interface [polypeptide binding]; other site 1156913007737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913007738 DNA binding residues [nucleotide binding] 1156913007739 dimerization interface [polypeptide binding]; other site 1156913007740 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1156913007741 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1156913007742 CysD dimerization site [polypeptide binding]; other site 1156913007743 G1 box; other site 1156913007744 putative GEF interaction site [polypeptide binding]; other site 1156913007745 GTP/Mg2+ binding site [chemical binding]; other site 1156913007746 Switch I region; other site 1156913007747 G2 box; other site 1156913007748 G3 box; other site 1156913007749 Switch II region; other site 1156913007750 G4 box; other site 1156913007751 G5 box; other site 1156913007752 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1156913007753 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1156913007754 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1156913007755 ligand-binding site [chemical binding]; other site 1156913007756 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1156913007757 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1156913007758 Active Sites [active] 1156913007759 SnoaL-like domain; Region: SnoaL_4; pfam13577 1156913007760 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1156913007761 short chain dehydrogenase; Provisional; Region: PRK07890 1156913007762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913007763 NAD(P) binding site [chemical binding]; other site 1156913007764 active site 1156913007765 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1156913007766 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1156913007767 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1156913007768 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913007769 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913007770 metal binding site [ion binding]; metal-binding site 1156913007771 active site 1156913007772 I-site; other site 1156913007773 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 1156913007774 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1156913007775 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1156913007776 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1156913007777 Zn2+ binding site [ion binding]; other site 1156913007778 Mg2+ binding site [ion binding]; other site 1156913007779 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1156913007780 putative active site [active] 1156913007781 putative catalytic triad [active] 1156913007782 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1156913007783 peptide chain release factor 1; Provisional; Region: PRK04011 1156913007784 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1156913007785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913007786 Walker A/P-loop; other site 1156913007787 ATP binding site [chemical binding]; other site 1156913007788 Q-loop/lid; other site 1156913007789 ABC transporter signature motif; other site 1156913007790 Walker B; other site 1156913007791 D-loop; other site 1156913007792 H-loop/switch region; other site 1156913007793 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913007794 Predicted transcriptional regulator [Transcription]; Region: COG4190 1156913007795 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913007796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913007797 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1156913007798 Walker A/P-loop; other site 1156913007799 ATP binding site [chemical binding]; other site 1156913007800 Q-loop/lid; other site 1156913007801 ABC transporter signature motif; other site 1156913007802 Walker B; other site 1156913007803 D-loop; other site 1156913007804 H-loop/switch region; other site 1156913007805 hypothetical protein; Provisional; Region: PRK02947 1156913007806 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1156913007807 putative active site [active] 1156913007808 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913007809 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913007810 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1156913007811 catalytic site [active] 1156913007812 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1156913007813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913007814 S-adenosylmethionine binding site [chemical binding]; other site 1156913007815 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1156913007816 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913007817 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913007818 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1156913007819 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1156913007820 catalytic triad [active] 1156913007821 PAS domain S-box; Region: sensory_box; TIGR00229 1156913007822 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1156913007823 putative active site [active] 1156913007824 heme pocket [chemical binding]; other site 1156913007825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913007826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913007827 metal binding site [ion binding]; metal-binding site 1156913007828 active site 1156913007829 I-site; other site 1156913007830 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1156913007831 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913007832 Cytochrome P450; Region: p450; cl12078 1156913007833 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1156913007834 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1156913007835 THF binding site; other site 1156913007836 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1156913007837 substrate binding site [chemical binding]; other site 1156913007838 THF binding site; other site 1156913007839 zinc-binding site [ion binding]; other site 1156913007840 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1156913007841 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1156913007842 dimer interface [polypeptide binding]; other site 1156913007843 putative radical transfer pathway; other site 1156913007844 diiron center [ion binding]; other site 1156913007845 tyrosyl radical; other site 1156913007846 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1156913007847 ATP cone domain; Region: ATP-cone; pfam03477 1156913007848 ATP cone domain; Region: ATP-cone; pfam03477 1156913007849 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1156913007850 active site 1156913007851 dimer interface [polypeptide binding]; other site 1156913007852 catalytic residues [active] 1156913007853 effector binding site; other site 1156913007854 R2 peptide binding site; other site 1156913007855 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1156913007856 enoyl-CoA hydratase; Provisional; Region: PRK08260 1156913007857 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913007858 substrate binding site [chemical binding]; other site 1156913007859 oxyanion hole (OAH) forming residues; other site 1156913007860 trimer interface [polypeptide binding]; other site 1156913007861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913007862 binding surface 1156913007863 TPR motif; other site 1156913007864 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1156913007865 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913007866 DNA binding residues [nucleotide binding] 1156913007867 putative dimer interface [polypeptide binding]; other site 1156913007868 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1156913007869 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1156913007870 hypothetical protein; Provisional; Region: PRK07588 1156913007871 hypothetical protein; Provisional; Region: PRK07236 1156913007872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913007873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913007874 TIGR03084 family protein; Region: TIGR03084 1156913007875 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1156913007876 Wyosine base formation; Region: Wyosine_form; pfam08608 1156913007877 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1156913007878 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913007879 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913007880 active site 1156913007881 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1156913007882 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1156913007883 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1156913007884 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1156913007885 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1156913007886 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1156913007887 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1156913007888 carboxyltransferase (CT) interaction site; other site 1156913007889 biotinylation site [posttranslational modification]; other site 1156913007890 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1156913007891 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1156913007892 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1156913007893 active site 1156913007894 short chain dehydrogenase; Provisional; Region: PRK08278 1156913007895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913007896 NAD(P) binding site [chemical binding]; other site 1156913007897 active site 1156913007898 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1156913007899 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913007900 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1156913007901 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1156913007902 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1156913007903 active site 1156913007904 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913007905 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913007906 metal binding site [ion binding]; metal-binding site 1156913007907 active site 1156913007908 I-site; other site 1156913007909 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1156913007910 nucleoside/Zn binding site; other site 1156913007911 dimer interface [polypeptide binding]; other site 1156913007912 catalytic motif [active] 1156913007913 WYL domain; Region: WYL; pfam13280 1156913007914 metabolite-proton symporter; Region: 2A0106; TIGR00883 1156913007915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913007916 putative substrate translocation pore; other site 1156913007917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913007918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913007919 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1156913007920 classical (c) SDRs; Region: SDR_c; cd05233 1156913007921 NAD(P) binding site [chemical binding]; other site 1156913007922 active site 1156913007923 classical (c) SDRs; Region: SDR_c; cd05233 1156913007924 NAD(P) binding site [chemical binding]; other site 1156913007925 active site 1156913007926 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1156913007927 active site clefts [active] 1156913007928 zinc binding site [ion binding]; other site 1156913007929 dimer interface [polypeptide binding]; other site 1156913007930 enoyl-CoA hydratase; Provisional; Region: PRK06210 1156913007931 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913007932 substrate binding site [chemical binding]; other site 1156913007933 oxyanion hole (OAH) forming residues; other site 1156913007934 trimer interface [polypeptide binding]; other site 1156913007935 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1156913007936 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1156913007937 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1156913007938 acyl-activating enzyme (AAE) consensus motif; other site 1156913007939 putative AMP binding site [chemical binding]; other site 1156913007940 putative active site [active] 1156913007941 putative CoA binding site [chemical binding]; other site 1156913007942 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1156913007943 active site 1156913007944 substrate binding pocket [chemical binding]; other site 1156913007945 homodimer interaction site [polypeptide binding]; other site 1156913007946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913007947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913007948 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913007949 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913007950 active site 1156913007951 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913007952 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1156913007953 FAD binding site [chemical binding]; other site 1156913007954 substrate binding site [chemical binding]; other site 1156913007955 catalytic base [active] 1156913007956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913007957 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 1156913007958 FAD binding site [chemical binding]; other site 1156913007959 substrate binding site [chemical binding]; other site 1156913007960 catalytic base [active] 1156913007961 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1156913007962 putative active site [active] 1156913007963 putative substrate binding site [chemical binding]; other site 1156913007964 ATP binding site [chemical binding]; other site 1156913007965 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1156913007966 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1156913007967 putative active site [active] 1156913007968 putative catalytic site [active] 1156913007969 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913007970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913007971 NAD(P) binding site [chemical binding]; other site 1156913007972 active site 1156913007973 Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611 1156913007974 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1156913007975 ATP binding site [chemical binding]; other site 1156913007976 dimerization interface [polypeptide binding]; other site 1156913007977 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1156913007978 trimer interface [polypeptide binding]; other site 1156913007979 active site 1156913007980 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913007981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913007982 non-specific DNA binding site [nucleotide binding]; other site 1156913007983 salt bridge; other site 1156913007984 sequence-specific DNA binding site [nucleotide binding]; other site 1156913007985 chaperone protein DnaJ; Provisional; Region: PRK14297 1156913007986 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1156913007987 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1156913007988 active site 1156913007989 Zn binding site [ion binding]; other site 1156913007990 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1156913007991 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1156913007992 HSP70 interaction site [polypeptide binding]; other site 1156913007993 Nuclease-related domain; Region: NERD; pfam08378 1156913007994 amino acid transporter; Region: 2A0306; TIGR00909 1156913007995 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913007996 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913007997 Predicted flavoprotein [General function prediction only]; Region: COG0431 1156913007998 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1156913007999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913008000 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1156913008001 Walker A/P-loop; other site 1156913008002 ATP binding site [chemical binding]; other site 1156913008003 Q-loop/lid; other site 1156913008004 ABC transporter signature motif; other site 1156913008005 Walker B; other site 1156913008006 D-loop; other site 1156913008007 H-loop/switch region; other site 1156913008008 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1156913008009 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913008010 AAA ATPase domain; Region: AAA_16; pfam13191 1156913008011 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913008012 Cytochrome P450; Region: p450; cl12078 1156913008013 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1156913008014 short chain dehydrogenase; Validated; Region: PRK05855 1156913008015 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1156913008016 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1156913008017 probable active site [active] 1156913008018 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1156913008019 RibD C-terminal domain; Region: RibD_C; cl17279 1156913008020 NB-ARC domain; Region: NB-ARC; pfam00931 1156913008021 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913008023 binding surface 1156913008024 TPR motif; other site 1156913008025 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008026 TPR repeat; Region: TPR_11; pfam13414 1156913008027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913008028 binding surface 1156913008029 TPR motif; other site 1156913008030 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008031 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913008033 binding surface 1156913008034 TPR motif; other site 1156913008035 AAA ATPase domain; Region: AAA_16; pfam13191 1156913008036 NB-ARC domain; Region: NB-ARC; pfam00931 1156913008037 TPR repeat; Region: TPR_11; pfam13414 1156913008038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913008039 TPR motif; other site 1156913008040 binding surface 1156913008041 TPR repeat; Region: TPR_11; pfam13414 1156913008042 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913008044 binding surface 1156913008045 TPR motif; other site 1156913008046 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008047 Condensation domain; Region: Condensation; pfam00668 1156913008048 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913008049 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913008050 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913008051 acyl-activating enzyme (AAE) consensus motif; other site 1156913008052 AMP binding site [chemical binding]; other site 1156913008053 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913008054 Condensation domain; Region: Condensation; pfam00668 1156913008055 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913008056 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913008057 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913008058 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1156913008059 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913008060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913008061 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913008062 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913008063 acyl-activating enzyme (AAE) consensus motif; other site 1156913008064 AMP binding site [chemical binding]; other site 1156913008065 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913008066 Condensation domain; Region: Condensation; pfam00668 1156913008067 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913008068 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913008069 acyl-activating enzyme (AAE) consensus motif; other site 1156913008070 AMP binding site [chemical binding]; other site 1156913008071 active site 1156913008072 CoA binding site [chemical binding]; other site 1156913008073 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913008074 Condensation domain; Region: Condensation; pfam00668 1156913008075 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913008076 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913008077 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913008078 acyl-activating enzyme (AAE) consensus motif; other site 1156913008079 AMP binding site [chemical binding]; other site 1156913008080 active site 1156913008081 CoA binding site [chemical binding]; other site 1156913008082 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913008083 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913008084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913008085 non-specific DNA binding site [nucleotide binding]; other site 1156913008086 salt bridge; other site 1156913008087 sequence-specific DNA binding site [nucleotide binding]; other site 1156913008088 NB-ARC domain; Region: NB-ARC; pfam00931 1156913008089 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008090 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913008091 binding surface 1156913008092 TPR motif; other site 1156913008093 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008094 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1156913008096 binding surface 1156913008097 TPR motif; other site 1156913008098 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008099 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913008100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913008101 non-specific DNA binding site [nucleotide binding]; other site 1156913008102 salt bridge; other site 1156913008103 sequence-specific DNA binding site [nucleotide binding]; other site 1156913008104 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1156913008105 Peptidase family M23; Region: Peptidase_M23; pfam01551 1156913008106 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913008107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1156913008108 sequence-specific DNA binding site [nucleotide binding]; other site 1156913008109 salt bridge; other site 1156913008110 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913008111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913008112 DNA binding residues [nucleotide binding] 1156913008113 dimerization interface [polypeptide binding]; other site 1156913008114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913008115 S-adenosylmethionine binding site [chemical binding]; other site 1156913008116 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1156913008117 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913008118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913008119 active site 1156913008120 phosphorylation site [posttranslational modification] 1156913008121 intermolecular recognition site; other site 1156913008122 dimerization interface [polypeptide binding]; other site 1156913008123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913008124 DNA binding residues [nucleotide binding] 1156913008125 dimerization interface [polypeptide binding]; other site 1156913008126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913008127 Histidine kinase; Region: HisKA_3; pfam07730 1156913008128 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913008129 ATP binding site [chemical binding]; other site 1156913008130 Mg2+ binding site [ion binding]; other site 1156913008131 G-X-G motif; other site 1156913008132 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1156913008133 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913008134 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1156913008135 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1156913008136 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1156913008137 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913008138 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1156913008139 homodimer interface [polypeptide binding]; other site 1156913008140 active site 1156913008141 TDP-binding site; other site 1156913008142 acceptor substrate-binding pocket; other site 1156913008143 acyl-CoA synthetase; Validated; Region: PRK06188 1156913008144 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1156913008145 acyl-activating enzyme (AAE) consensus motif; other site 1156913008146 putative AMP binding site [chemical binding]; other site 1156913008147 putative active site [active] 1156913008148 putative CoA binding site [chemical binding]; other site 1156913008149 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1156913008150 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1156913008151 substrate-cofactor binding pocket; other site 1156913008152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913008153 catalytic residue [active] 1156913008154 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1156913008155 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1156913008156 acyl-activating enzyme (AAE) consensus motif; other site 1156913008157 putative AMP binding site [chemical binding]; other site 1156913008158 putative active site [active] 1156913008159 putative CoA binding site [chemical binding]; other site 1156913008160 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008161 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008162 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1156913008163 active site 1156913008164 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1156913008165 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008166 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913008167 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008168 putative NADP binding site [chemical binding]; other site 1156913008169 KR domain; Region: KR; pfam08659 1156913008170 active site 1156913008171 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008172 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913008173 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008174 active site 1156913008175 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008176 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913008177 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008178 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1156913008179 Enoylreductase; Region: PKS_ER; smart00829 1156913008180 NAD(P) binding site [chemical binding]; other site 1156913008181 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008182 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913008183 putative NADP binding site [chemical binding]; other site 1156913008184 active site 1156913008185 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008186 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913008187 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008188 active site 1156913008189 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008190 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913008191 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008192 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913008193 putative NADP binding site [chemical binding]; other site 1156913008194 active site 1156913008195 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008196 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913008197 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008198 active site 1156913008199 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008200 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913008201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913008202 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1156913008203 Enoylreductase; Region: PKS_ER; smart00829 1156913008204 NAD(P) binding site [chemical binding]; other site 1156913008205 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008206 putative NADP binding site [chemical binding]; other site 1156913008207 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913008208 active site 1156913008209 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008210 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913008211 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008212 active site 1156913008213 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008214 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913008215 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008216 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1156913008217 Enoylreductase; Region: PKS_ER; smart00829 1156913008218 NAD(P) binding site [chemical binding]; other site 1156913008219 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008220 putative NADP binding site [chemical binding]; other site 1156913008221 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913008222 active site 1156913008223 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008224 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913008225 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008226 active site 1156913008227 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008228 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913008229 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008230 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913008231 putative NADP binding site [chemical binding]; other site 1156913008232 active site 1156913008233 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008234 Erythronolide synthase docking; Region: Docking; pfam08990 1156913008235 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008236 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1156913008237 active site 1156913008238 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1156913008239 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008240 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 1156913008241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913008242 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008243 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913008244 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008245 active site 1156913008246 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008247 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913008248 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008249 putative NADP binding site [chemical binding]; other site 1156913008250 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913008251 active site 1156913008252 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008253 Erythronolide synthase docking; Region: Docking; pfam08990 1156913008254 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913008255 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008256 active site 1156913008257 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008258 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913008259 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008260 putative NADP binding site [chemical binding]; other site 1156913008261 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913008262 active site 1156913008263 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008264 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913008265 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008266 active site 1156913008267 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008268 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913008269 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008270 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913008271 putative NADP binding site [chemical binding]; other site 1156913008272 active site 1156913008273 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008274 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913008275 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008276 active site 1156913008277 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008278 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913008279 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008280 putative NADP binding site [chemical binding]; other site 1156913008281 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913008282 active site 1156913008283 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008284 Erythronolide synthase docking; Region: Docking; pfam08990 1156913008285 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913008286 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913008287 active site 1156913008288 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913008289 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913008290 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913008291 putative NADP binding site [chemical binding]; other site 1156913008292 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913008293 active site 1156913008294 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913008295 Thioesterase; Region: PKS_TE; smart00824 1156913008296 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1156913008297 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1156913008298 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1156913008299 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913008300 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1156913008301 acyl-activating enzyme (AAE) consensus motif; other site 1156913008302 acyl-activating enzyme (AAE) consensus motif; other site 1156913008303 AMP binding site [chemical binding]; other site 1156913008304 active site 1156913008305 CoA binding site [chemical binding]; other site 1156913008306 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1156913008307 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1156913008308 Helix-turn-helix domain; Region: HTH_18; pfam12833 1156913008309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913008310 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913008311 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1156913008312 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 1156913008313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913008314 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913008315 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1156913008316 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913008317 conserved cys residue [active] 1156913008318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913008319 DJ-1 family protein; Region: not_thiJ; TIGR01383 1156913008320 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1156913008321 conserved cys residue [active] 1156913008322 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1156913008323 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1156913008324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913008325 Walker A/P-loop; other site 1156913008326 ATP binding site [chemical binding]; other site 1156913008327 Q-loop/lid; other site 1156913008328 ABC transporter signature motif; other site 1156913008329 Walker B; other site 1156913008330 D-loop; other site 1156913008331 H-loop/switch region; other site 1156913008332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913008333 Walker A/P-loop; other site 1156913008334 ATP binding site [chemical binding]; other site 1156913008335 Q-loop/lid; other site 1156913008336 ABC transporter signature motif; other site 1156913008337 Walker B; other site 1156913008338 D-loop; other site 1156913008339 H-loop/switch region; other site 1156913008340 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1156913008341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913008342 dimer interface [polypeptide binding]; other site 1156913008343 conserved gate region; other site 1156913008344 putative PBP binding loops; other site 1156913008345 ABC-ATPase subunit interface; other site 1156913008346 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1156913008347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1156913008348 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1156913008349 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1156913008350 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1156913008351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913008352 S-adenosylmethionine binding site [chemical binding]; other site 1156913008353 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1156913008354 peptide chain release factor 1; Provisional; Region: PRK04011 1156913008355 propionate/acetate kinase; Provisional; Region: PRK12379 1156913008356 Acetokinase family; Region: Acetate_kinase; cl17229 1156913008357 putative phosphoketolase; Provisional; Region: PRK05261 1156913008358 XFP N-terminal domain; Region: XFP_N; pfam09364 1156913008359 XFP C-terminal domain; Region: XFP_C; pfam09363 1156913008360 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913008361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913008362 active site 1156913008363 phosphorylation site [posttranslational modification] 1156913008364 intermolecular recognition site; other site 1156913008365 dimerization interface [polypeptide binding]; other site 1156913008366 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913008367 DNA binding residues [nucleotide binding] 1156913008368 dimerization interface [polypeptide binding]; other site 1156913008369 Histidine kinase; Region: HisKA_3; pfam07730 1156913008370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913008371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913008372 ATP binding site [chemical binding]; other site 1156913008373 Mg2+ binding site [ion binding]; other site 1156913008374 G-X-G motif; other site 1156913008375 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913008376 putative DNA binding site [nucleotide binding]; other site 1156913008377 putative Zn2+ binding site [ion binding]; other site 1156913008378 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1156913008379 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1156913008380 active site 1156913008381 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913008382 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913008383 active site 1156913008384 metal binding site [ion binding]; metal-binding site 1156913008385 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1156913008386 Chromate transporter; Region: Chromate_transp; pfam02417 1156913008387 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1156913008388 active site clefts [active] 1156913008389 zinc binding site [ion binding]; other site 1156913008390 dimer interface [polypeptide binding]; other site 1156913008391 MarR family; Region: MarR_2; pfam12802 1156913008392 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1156913008393 Predicted ATPase [General function prediction only]; Region: COG3903 1156913008394 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913008395 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913008396 DNA binding residues [nucleotide binding] 1156913008397 dimerization interface [polypeptide binding]; other site 1156913008398 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913008399 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913008400 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1156913008401 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913008402 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1156913008403 acyl-activating enzyme (AAE) consensus motif; other site 1156913008404 acyl-activating enzyme (AAE) consensus motif; other site 1156913008405 putative AMP binding site [chemical binding]; other site 1156913008406 putative active site [active] 1156913008407 putative CoA binding site [chemical binding]; other site 1156913008408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913008409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913008410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913008411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913008412 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913008413 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1156913008414 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913008415 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1156913008416 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1156913008417 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1156913008418 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1156913008419 active site 1156913008420 intersubunit interface [polypeptide binding]; other site 1156913008421 catalytic residue [active] 1156913008422 galactonate dehydratase; Provisional; Region: PRK14017 1156913008423 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1156913008424 putative active site pocket [active] 1156913008425 putative metal binding site [ion binding]; other site 1156913008426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913008427 D-galactonate transporter; Region: 2A0114; TIGR00893 1156913008428 putative substrate translocation pore; other site 1156913008429 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1156913008430 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1156913008431 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1156913008432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913008433 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1156913008434 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1156913008435 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1156913008436 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1156913008437 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1156913008438 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1156913008439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913008440 Histidine kinase; Region: HisKA_3; pfam07730 1156913008441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913008442 ATP binding site [chemical binding]; other site 1156913008443 Mg2+ binding site [ion binding]; other site 1156913008444 G-X-G motif; other site 1156913008445 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913008446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913008447 active site 1156913008448 phosphorylation site [posttranslational modification] 1156913008449 intermolecular recognition site; other site 1156913008450 dimerization interface [polypeptide binding]; other site 1156913008451 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913008452 DNA binding residues [nucleotide binding] 1156913008453 dimerization interface [polypeptide binding]; other site 1156913008454 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913008455 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913008456 active site 1156913008457 catalytic tetrad [active] 1156913008458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913008459 sequence-specific DNA binding site [nucleotide binding]; other site 1156913008460 salt bridge; other site 1156913008461 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1156913008462 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913008463 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1156913008464 acyl-CoA synthetase; Validated; Region: PRK05850 1156913008465 acyl-activating enzyme (AAE) consensus motif; other site 1156913008466 active site 1156913008467 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1156913008468 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1156913008469 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1156913008470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913008471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913008472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913008473 dimerization interface [polypeptide binding]; other site 1156913008474 tartrate dehydrogenase; Provisional; Region: PRK08194 1156913008475 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1156913008476 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1156913008477 hydrophobic ligand binding site; other site 1156913008478 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913008479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913008480 NAD(P) binding site [chemical binding]; other site 1156913008481 active site 1156913008482 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1156913008483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913008484 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1156913008485 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1156913008486 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913008487 putative NAD(P) binding site [chemical binding]; other site 1156913008488 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913008489 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913008490 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1156913008491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913008492 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913008493 Domain of unknown function (DUF385); Region: DUF385; cl04387 1156913008494 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913008495 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913008496 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913008497 Ligand Binding Site [chemical binding]; other site 1156913008498 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913008499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913008500 putative substrate translocation pore; other site 1156913008501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913008502 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1156913008503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913008504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913008505 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913008506 dimerization interface [polypeptide binding]; other site 1156913008507 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 1156913008508 NmrA-like family; Region: NmrA; pfam05368 1156913008509 putative NADP binding site [chemical binding]; other site 1156913008510 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1156913008511 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913008512 homodimer interface [polypeptide binding]; other site 1156913008513 active site 1156913008514 TDP-binding site; other site 1156913008515 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913008516 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913008517 DNA binding residues [nucleotide binding] 1156913008518 dimerization interface [polypeptide binding]; other site 1156913008519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913008520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913008521 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913008523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913008524 DNA binding residues [nucleotide binding] 1156913008525 dimerization interface [polypeptide binding]; other site 1156913008526 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913008527 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913008528 DNA binding residues [nucleotide binding] 1156913008529 dimerization interface [polypeptide binding]; other site 1156913008530 HicB family; Region: HicB; pfam05534 1156913008531 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1156913008532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913008533 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1156913008534 Walker A/P-loop; other site 1156913008535 ATP binding site [chemical binding]; other site 1156913008536 Q-loop/lid; other site 1156913008537 ABC transporter signature motif; other site 1156913008538 Walker B; other site 1156913008539 D-loop; other site 1156913008540 H-loop/switch region; other site 1156913008541 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1156913008542 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913008543 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913008544 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913008545 active site 1156913008546 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913008547 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1156913008548 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913008549 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913008550 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913008551 Walker A/P-loop; other site 1156913008552 ATP binding site [chemical binding]; other site 1156913008553 Q-loop/lid; other site 1156913008554 ABC transporter signature motif; other site 1156913008555 Walker B; other site 1156913008556 D-loop; other site 1156913008557 H-loop/switch region; other site 1156913008558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913008559 Histidine kinase; Region: HisKA_3; pfam07730 1156913008560 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913008561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913008562 active site 1156913008563 phosphorylation site [posttranslational modification] 1156913008564 intermolecular recognition site; other site 1156913008565 dimerization interface [polypeptide binding]; other site 1156913008566 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913008567 DNA binding residues [nucleotide binding] 1156913008568 dimerization interface [polypeptide binding]; other site 1156913008569 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913008570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913008571 non-specific DNA binding site [nucleotide binding]; other site 1156913008572 salt bridge; other site 1156913008573 sequence-specific DNA binding site [nucleotide binding]; other site 1156913008574 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913008575 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1156913008576 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1156913008577 DinB superfamily; Region: DinB_2; pfam12867 1156913008578 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913008579 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 1156913008580 DNA binding residues [nucleotide binding] 1156913008581 putative dimer interface [polypeptide binding]; other site 1156913008582 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 1156913008583 DNA binding residues [nucleotide binding] 1156913008584 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913008585 putative dimer interface [polypeptide binding]; other site 1156913008586 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1156913008587 DNA binding residues [nucleotide binding] 1156913008588 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 1156913008589 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913008590 DNA binding residues [nucleotide binding] 1156913008591 putative dimer interface [polypeptide binding]; other site 1156913008592 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1156913008593 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1156913008594 catalytic triad [active] 1156913008595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913008596 S-adenosylmethionine binding site [chemical binding]; other site 1156913008597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913008598 dimerization interface [polypeptide binding]; other site 1156913008599 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1156913008600 cyclase homology domain; Region: CHD; cd07302 1156913008601 nucleotidyl binding site; other site 1156913008602 metal binding site [ion binding]; metal-binding site 1156913008603 dimer interface [polypeptide binding]; other site 1156913008604 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1156913008605 putative active site [active] 1156913008606 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913008607 non-specific DNA binding site [nucleotide binding]; other site 1156913008608 salt bridge; other site 1156913008609 sequence-specific DNA binding site [nucleotide binding]; other site 1156913008610 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913008611 Cytochrome P450; Region: p450; cl12078 1156913008612 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1156913008613 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1156913008614 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1156913008615 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1156913008616 active site 1156913008617 homodimer interface [polypeptide binding]; other site 1156913008618 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1156913008619 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913008620 active site 1156913008621 hypothetical protein; Provisional; Region: PRK07338 1156913008622 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1156913008623 metal binding site [ion binding]; metal-binding site 1156913008624 dimer interface [polypeptide binding]; other site 1156913008625 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1156913008626 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1156913008627 glutaminase active site [active] 1156913008628 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1156913008629 dimer interface [polypeptide binding]; other site 1156913008630 active site 1156913008631 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1156913008632 dimer interface [polypeptide binding]; other site 1156913008633 active site 1156913008634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1156913008635 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1156913008636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913008637 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1156913008638 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1156913008639 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1156913008640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913008641 dimer interface [polypeptide binding]; other site 1156913008642 putative PBP binding loops; other site 1156913008643 ABC-ATPase subunit interface; other site 1156913008644 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913008645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913008646 dimer interface [polypeptide binding]; other site 1156913008647 conserved gate region; other site 1156913008648 putative PBP binding loops; other site 1156913008649 ABC-ATPase subunit interface; other site 1156913008650 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913008651 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913008652 active site 1156913008653 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913008654 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913008655 metal binding site [ion binding]; metal-binding site 1156913008656 active site 1156913008657 I-site; other site 1156913008658 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913008659 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1156913008660 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913008661 conserved cys residue [active] 1156913008662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913008663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913008664 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1156913008665 HEAT repeats; Region: HEAT_2; pfam13646 1156913008666 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1156913008667 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1156913008668 DNA binding residues [nucleotide binding] 1156913008669 putative dimer interface [polypeptide binding]; other site 1156913008670 DNA polymerase IV; Validated; Region: PRK03858 1156913008671 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1156913008672 active site 1156913008673 DNA binding site [nucleotide binding] 1156913008674 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1156913008675 RNA/DNA hybrid binding site [nucleotide binding]; other site 1156913008676 active site 1156913008677 Sporulation and spore germination; Region: Germane; cl11253 1156913008678 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913008679 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913008680 dimerization interface [polypeptide binding]; other site 1156913008681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913008682 dimer interface [polypeptide binding]; other site 1156913008683 phosphorylation site [posttranslational modification] 1156913008684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913008685 ATP binding site [chemical binding]; other site 1156913008686 Mg2+ binding site [ion binding]; other site 1156913008687 G-X-G motif; other site 1156913008688 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913008689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913008690 active site 1156913008691 phosphorylation site [posttranslational modification] 1156913008692 intermolecular recognition site; other site 1156913008693 dimerization interface [polypeptide binding]; other site 1156913008694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913008695 DNA binding site [nucleotide binding] 1156913008696 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1156913008697 active site 1156913008698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913008699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913008700 metal binding site [ion binding]; metal-binding site 1156913008701 active site 1156913008702 I-site; other site 1156913008703 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913008704 Cytochrome P450; Region: p450; cl12078 1156913008705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913008706 non-specific DNA binding site [nucleotide binding]; other site 1156913008707 salt bridge; other site 1156913008708 sequence-specific DNA binding site [nucleotide binding]; other site 1156913008709 AAA ATPase domain; Region: AAA_16; pfam13191 1156913008710 NB-ARC domain; Region: NB-ARC; pfam00931 1156913008711 Walker A motif; other site 1156913008712 ATP binding site [chemical binding]; other site 1156913008713 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913008715 binding surface 1156913008716 TPR motif; other site 1156913008717 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008718 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913008720 TPR motif; other site 1156913008721 binding surface 1156913008722 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008723 EamA-like transporter family; Region: EamA; pfam00892 1156913008724 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1156913008725 EamA-like transporter family; Region: EamA; cl17759 1156913008726 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913008727 active site 1156913008728 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1156913008729 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1156913008730 NAD binding site [chemical binding]; other site 1156913008731 catalytic Zn binding site [ion binding]; other site 1156913008732 structural Zn binding site [ion binding]; other site 1156913008733 FOG: CBS domain [General function prediction only]; Region: COG0517 1156913008734 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1156913008735 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 1156913008736 oligomer interface [polypeptide binding]; other site 1156913008737 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1156913008738 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913008739 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 1156913008740 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913008741 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913008742 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1156913008743 hydrophobic ligand binding site; other site 1156913008744 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1156913008745 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913008746 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913008747 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1156913008748 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1156913008749 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1156913008750 WHG domain; Region: WHG; pfam13305 1156913008751 amidase; Provisional; Region: PRK08137 1156913008752 Amidase; Region: Amidase; pfam01425 1156913008753 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913008754 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1156913008755 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913008756 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913008757 active site 1156913008758 ATP binding site [chemical binding]; other site 1156913008759 substrate binding site [chemical binding]; other site 1156913008760 activation loop (A-loop); other site 1156913008761 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1156913008762 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913008763 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913008764 Cytochrome P450; Region: p450; cl12078 1156913008765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913008766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913008767 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913008768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913008769 Coenzyme A binding pocket [chemical binding]; other site 1156913008770 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913008771 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913008772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913008773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913008774 short chain dehydrogenase; Provisional; Region: PRK06172 1156913008775 classical (c) SDRs; Region: SDR_c; cd05233 1156913008776 NAD(P) binding site [chemical binding]; other site 1156913008777 active site 1156913008778 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1156913008779 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1156913008780 PYR/PP interface [polypeptide binding]; other site 1156913008781 dimer interface [polypeptide binding]; other site 1156913008782 tetramer interface [polypeptide binding]; other site 1156913008783 TPP binding site [chemical binding]; other site 1156913008784 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1156913008785 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1156913008786 TPP-binding site [chemical binding]; other site 1156913008787 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1156913008788 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913008789 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1156913008790 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1156913008791 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1156913008792 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1156913008793 putative hydrophobic ligand binding site [chemical binding]; other site 1156913008794 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1156913008795 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1156913008796 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913008797 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1156913008798 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913008799 DNA binding residues [nucleotide binding] 1156913008800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1156913008801 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913008802 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1156913008803 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1156913008804 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1156913008805 Fe-S cluster binding site [ion binding]; other site 1156913008806 active site 1156913008807 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913008808 Cytochrome P450; Region: p450; cl12078 1156913008809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913008810 non-specific DNA binding site [nucleotide binding]; other site 1156913008811 salt bridge; other site 1156913008812 sequence-specific DNA binding site [nucleotide binding]; other site 1156913008813 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1156913008814 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913008815 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1156913008816 dimer interface [polypeptide binding]; other site 1156913008817 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1156913008818 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1156913008819 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913008820 Cupin domain; Region: Cupin_2; cl17218 1156913008821 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1156913008822 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 1156913008823 active site 1156913008824 nucleotide binding site [chemical binding]; other site 1156913008825 HIGH motif; other site 1156913008826 KMSKS motif; other site 1156913008827 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913008828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913008829 putative substrate translocation pore; other site 1156913008830 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1156913008831 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1156913008832 Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; Region: PurD; COG0151 1156913008833 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1156913008834 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 1156913008835 B12 binding site [chemical binding]; other site 1156913008836 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 1156913008837 substrate binding site [chemical binding]; other site 1156913008838 B12 cofactor binding site [chemical binding]; other site 1156913008839 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 1156913008840 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 1156913008841 asparagine synthetase A; Reviewed; Region: PRK06462 1156913008842 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1156913008843 motif 1; other site 1156913008844 dimer interface [polypeptide binding]; other site 1156913008845 active site 1156913008846 motif 2; other site 1156913008847 motif 3; other site 1156913008848 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1156913008849 phosphate binding site [ion binding]; other site 1156913008850 Protein of unknown function (DUF419); Region: DUF419; cl15265 1156913008851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1156913008852 NB-ARC domain; Region: NB-ARC; pfam00931 1156913008853 Walker A motif; other site 1156913008854 ATP binding site [chemical binding]; other site 1156913008855 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1156913008856 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1156913008857 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1156913008858 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1156913008859 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1156913008860 Amidinotransferase; Region: Amidinotransf; pfam02274 1156913008861 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1156913008862 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1156913008863 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1156913008864 substrate binding pocket [chemical binding]; other site 1156913008865 active site 1156913008866 iron coordination sites [ion binding]; other site 1156913008867 short chain dehydrogenase; Provisional; Region: PRK06701 1156913008868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913008869 NAD(P) binding site [chemical binding]; other site 1156913008870 active site 1156913008871 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1156913008872 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1156913008873 putative active site [active] 1156913008874 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913008875 active site 1156913008876 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913008877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913008878 active site 1156913008879 motif I; other site 1156913008880 motif II; other site 1156913008881 hydroperoxidase II; Provisional; Region: katE; PRK11249 1156913008882 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1156913008883 tetramer interface [polypeptide binding]; other site 1156913008884 heme binding pocket [chemical binding]; other site 1156913008885 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1156913008886 domain interactions; other site 1156913008887 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913008888 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1156913008889 NAD(P) binding site [chemical binding]; other site 1156913008890 catalytic residues [active] 1156913008891 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913008892 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1156913008893 putative NAD(P) binding site [chemical binding]; other site 1156913008894 active site 1156913008895 putative substrate binding site [chemical binding]; other site 1156913008896 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1156913008897 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913008898 active site 1156913008899 metal binding site [ion binding]; metal-binding site 1156913008900 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913008901 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1156913008902 PhoU domain; Region: PhoU; pfam01895 1156913008903 PhoU domain; Region: PhoU; pfam01895 1156913008904 Hemerythrin-like domain; Region: Hr-like; cd12108 1156913008905 Fe binding site [ion binding]; other site 1156913008906 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1156913008907 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1156913008908 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1156913008909 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1156913008910 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1156913008911 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1156913008912 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1156913008913 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1156913008914 putative active site [active] 1156913008915 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1156913008916 classical (c) SDRs; Region: SDR_c; cd05233 1156913008917 NAD(P) binding site [chemical binding]; other site 1156913008918 active site 1156913008919 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1156913008920 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1156913008921 substrate binding site [chemical binding]; other site 1156913008922 ATP binding site [chemical binding]; other site 1156913008923 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1156913008924 active site 1156913008925 nucleotide binding site [chemical binding]; other site 1156913008926 HIGH motif; other site 1156913008927 KMSKS motif; other site 1156913008928 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1156913008929 dimer interface [polypeptide binding]; other site 1156913008930 active site 1156913008931 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1156913008932 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1156913008933 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1156913008934 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913008935 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1156913008936 NAD binding site [chemical binding]; other site 1156913008937 putative substrate binding site 2 [chemical binding]; other site 1156913008938 putative substrate binding site 1 [chemical binding]; other site 1156913008939 active site 1156913008940 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1156913008941 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913008942 active site 1156913008943 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1156913008944 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1156913008945 Probable Catalytic site; other site 1156913008946 metal-binding site 1156913008947 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1156913008948 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1156913008949 putative ADP-binding pocket [chemical binding]; other site 1156913008950 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913008951 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1156913008952 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1156913008953 putative methyltransferase; Provisional; Region: PRK14967 1156913008954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1156913008955 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 1156913008956 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1156913008957 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1156913008958 FAD dependent oxidoreductase; Region: DAO; pfam01266 1156913008959 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913008960 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1156913008961 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1156913008962 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1156913008963 [2Fe-2S] cluster binding site [ion binding]; other site 1156913008964 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1156913008965 Predicted acyl esterases [General function prediction only]; Region: COG2936 1156913008966 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913008967 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1156913008968 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1156913008969 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1156913008970 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1156913008971 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1156913008972 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913008973 Ligand Binding Site [chemical binding]; other site 1156913008974 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913008975 Ligand Binding Site [chemical binding]; other site 1156913008976 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1156913008977 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1156913008978 anti sigma factor interaction site; other site 1156913008979 regulatory phosphorylation site [posttranslational modification]; other site 1156913008980 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913008981 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1156913008982 anti sigma factor interaction site; other site 1156913008983 regulatory phosphorylation site [posttranslational modification]; other site 1156913008984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913008985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913008986 non-specific DNA binding site [nucleotide binding]; other site 1156913008987 salt bridge; other site 1156913008988 sequence-specific DNA binding site [nucleotide binding]; other site 1156913008989 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913008991 binding surface 1156913008992 TPR motif; other site 1156913008993 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913008994 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1156913008995 active site 1156913008996 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913008997 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1156913008998 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1156913008999 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913009000 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913009001 active site 1156913009002 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1156913009003 Isochorismatase family; Region: Isochorismatase; pfam00857 1156913009004 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1156913009005 catalytic triad [active] 1156913009006 conserved cis-peptide bond; other site 1156913009007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913009008 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913009009 active site 1156913009010 catalytic tetrad [active] 1156913009011 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1156913009012 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1156913009013 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1156913009014 Endonuclease I; Region: Endonuclease_1; pfam04231 1156913009015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1156913009016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913009017 Coenzyme A binding pocket [chemical binding]; other site 1156913009018 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1156913009019 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1156913009020 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1156913009021 conserved cys residue [active] 1156913009022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913009023 alpha-galactosidase; Region: PLN02808; cl17638 1156913009024 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1156913009025 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 1156913009026 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1156913009027 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1156913009028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913009029 ATP binding site [chemical binding]; other site 1156913009030 Walker A motif; other site 1156913009031 Walker B motif; other site 1156913009032 arginine finger; other site 1156913009033 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1156913009034 Phage-related protein [Function unknown]; Region: COG5412 1156913009035 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1156913009036 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1156913009037 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 1156913009038 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1156913009039 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1156913009040 Phage protein D [General function prediction only]; Region: COG3500 1156913009041 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1156913009042 PAAR motif; Region: PAAR_motif; cl15808 1156913009043 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1156913009044 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1156913009045 phage tail protein domain; Region: tail_TIGR02242 1156913009046 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1156913009047 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1156913009048 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1156913009049 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1156913009050 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1156913009051 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1156913009052 metal ion-dependent adhesion site (MIDAS); other site 1156913009053 Predicted membrane protein [Function unknown]; Region: COG1470 1156913009054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913009055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913009056 DNA binding residues [nucleotide binding] 1156913009057 dimerization interface [polypeptide binding]; other site 1156913009058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913009059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913009060 active site 1156913009061 phosphorylation site [posttranslational modification] 1156913009062 intermolecular recognition site; other site 1156913009063 dimerization interface [polypeptide binding]; other site 1156913009064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913009065 DNA binding residues [nucleotide binding] 1156913009066 dimerization interface [polypeptide binding]; other site 1156913009067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913009068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913009069 ATP binding site [chemical binding]; other site 1156913009070 Mg2+ binding site [ion binding]; other site 1156913009071 G-X-G motif; other site 1156913009072 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1156913009073 putative active site [active] 1156913009074 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1156913009075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913009076 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1156913009077 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1156913009078 cleavage site 1156913009079 active site 1156913009080 substrate binding sites [chemical binding]; other site 1156913009081 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913009082 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913009083 acyl-activating enzyme (AAE) consensus motif; other site 1156913009084 AMP binding site [chemical binding]; other site 1156913009085 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913009086 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913009087 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1156913009088 active site 1156913009089 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913009090 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913009091 acyl-activating enzyme (AAE) consensus motif; other site 1156913009092 AMP binding site [chemical binding]; other site 1156913009093 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913009094 Condensation domain; Region: Condensation; pfam00668 1156913009095 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913009096 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913009097 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913009098 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913009099 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913009100 active site 1156913009101 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913009102 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1156913009103 putative NADP binding site [chemical binding]; other site 1156913009104 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913009105 active site 1156913009106 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913009107 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913009108 Condensation domain; Region: Condensation; pfam00668 1156913009109 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913009110 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913009111 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913009112 acyl-activating enzyme (AAE) consensus motif; other site 1156913009113 AMP binding site [chemical binding]; other site 1156913009114 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913009115 Condensation domain; Region: Condensation; pfam00668 1156913009116 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913009117 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913009118 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913009119 acyl-activating enzyme (AAE) consensus motif; other site 1156913009120 AMP binding site [chemical binding]; other site 1156913009121 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913009122 Thioesterase domain; Region: Thioesterase; pfam00975 1156913009123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009124 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913009125 putative substrate translocation pore; other site 1156913009126 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1156913009127 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1156913009128 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1156913009129 active site 1156913009130 iron coordination sites [ion binding]; other site 1156913009131 substrate binding pocket [chemical binding]; other site 1156913009132 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913009133 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1156913009134 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913009135 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1156913009136 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1156913009137 metal binding site [ion binding]; metal-binding site 1156913009138 dimer interface [polypeptide binding]; other site 1156913009139 metabolite-proton symporter; Region: 2A0106; TIGR00883 1156913009140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009141 putative substrate translocation pore; other site 1156913009142 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913009143 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1156913009144 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 1156913009145 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 1156913009146 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1156913009147 PhoU domain; Region: PhoU; pfam01895 1156913009148 PhoU domain; Region: PhoU; pfam01895 1156913009149 short chain dehydrogenase; Provisional; Region: PRK06197 1156913009150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913009151 NAD(P) binding site [chemical binding]; other site 1156913009152 active site 1156913009153 Amino acid permease; Region: AA_permease_2; pfam13520 1156913009154 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1156913009155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913009156 Walker A/P-loop; other site 1156913009157 ATP binding site [chemical binding]; other site 1156913009158 Q-loop/lid; other site 1156913009159 ABC transporter signature motif; other site 1156913009160 Walker B; other site 1156913009161 D-loop; other site 1156913009162 H-loop/switch region; other site 1156913009163 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1156913009164 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913009165 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913009166 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913009167 Walker A/P-loop; other site 1156913009168 ATP binding site [chemical binding]; other site 1156913009169 Q-loop/lid; other site 1156913009170 ABC transporter signature motif; other site 1156913009171 Walker B; other site 1156913009172 D-loop; other site 1156913009173 H-loop/switch region; other site 1156913009174 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1156913009175 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1156913009176 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913009177 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913009178 Helix-turn-helix domain; Region: HTH_18; pfam12833 1156913009179 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1156913009180 putative hydrophobic ligand binding site [chemical binding]; other site 1156913009181 protein interface [polypeptide binding]; other site 1156913009182 gate; other site 1156913009183 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1156913009184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009185 putative substrate translocation pore; other site 1156913009186 MarR family; Region: MarR_2; cl17246 1156913009187 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913009188 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913009189 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1156913009190 classical (c) SDRs; Region: SDR_c; cd05233 1156913009191 NAD(P) binding site [chemical binding]; other site 1156913009192 active site 1156913009193 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1156913009194 putative active site [active] 1156913009195 putative substrate binding site [chemical binding]; other site 1156913009196 ATP binding site [chemical binding]; other site 1156913009197 Phosphotransferase enzyme family; Region: APH; pfam01636 1156913009198 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1156913009199 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1156913009200 active site 1156913009201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913009202 salt bridge; other site 1156913009203 non-specific DNA binding site [nucleotide binding]; other site 1156913009204 sequence-specific DNA binding site [nucleotide binding]; other site 1156913009205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913009206 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1156913009207 NAD(P) binding site [chemical binding]; other site 1156913009208 active site 1156913009209 Glyco_18 domain; Region: Glyco_18; smart00636 1156913009210 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1156913009211 active site 1156913009212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913009213 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913009214 dimerization interface [polypeptide binding]; other site 1156913009215 DNA binding residues [nucleotide binding] 1156913009216 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913009217 Condensation domain; Region: Condensation; pfam00668 1156913009218 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913009219 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913009220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913009221 dimerization interface [polypeptide binding]; other site 1156913009222 DNA binding residues [nucleotide binding] 1156913009223 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913009224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913009225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913009226 TPR motif; other site 1156913009227 binding surface 1156913009228 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913009229 TPR repeat; Region: TPR_11; pfam13414 1156913009230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913009231 binding surface 1156913009232 TPR motif; other site 1156913009233 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1156913009234 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1156913009235 hypothetical protein; Validated; Region: PRK07080 1156913009236 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1156913009237 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1156913009238 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1156913009239 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1156913009240 active site 1156913009241 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1156913009242 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1156913009243 Histidine kinase; Region: HisKA_3; pfam07730 1156913009244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913009245 ATP binding site [chemical binding]; other site 1156913009246 Mg2+ binding site [ion binding]; other site 1156913009247 G-X-G motif; other site 1156913009248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913009249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913009250 active site 1156913009251 phosphorylation site [posttranslational modification] 1156913009252 intermolecular recognition site; other site 1156913009253 dimerization interface [polypeptide binding]; other site 1156913009254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913009255 DNA binding residues [nucleotide binding] 1156913009256 dimerization interface [polypeptide binding]; other site 1156913009257 classical (c) SDRs; Region: SDR_c; cd05233 1156913009258 NAD(P) binding site [chemical binding]; other site 1156913009259 active site 1156913009260 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913009261 dimerization interface [polypeptide binding]; other site 1156913009262 putative Zn2+ binding site [ion binding]; other site 1156913009263 putative DNA binding site [nucleotide binding]; other site 1156913009264 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1156913009265 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1156913009266 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1156913009267 putative sugar binding sites [chemical binding]; other site 1156913009268 Q-X-W motif; other site 1156913009269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913009270 non-specific DNA binding site [nucleotide binding]; other site 1156913009271 salt bridge; other site 1156913009272 sequence-specific DNA binding site [nucleotide binding]; other site 1156913009273 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1156913009274 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1156913009275 structural tetrad; other site 1156913009276 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1156913009277 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1156913009278 structural tetrad; other site 1156913009279 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1156913009280 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1156913009281 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1156913009282 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1156913009283 Walker A/P-loop; other site 1156913009284 ATP binding site [chemical binding]; other site 1156913009285 Q-loop/lid; other site 1156913009286 ABC transporter signature motif; other site 1156913009287 Walker B; other site 1156913009288 D-loop; other site 1156913009289 H-loop/switch region; other site 1156913009290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913009291 dimer interface [polypeptide binding]; other site 1156913009292 conserved gate region; other site 1156913009293 ABC-ATPase subunit interface; other site 1156913009294 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1156913009295 AAA ATPase domain; Region: AAA_16; pfam13191 1156913009296 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913009297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913009298 DNA binding residues [nucleotide binding] 1156913009299 dimerization interface [polypeptide binding]; other site 1156913009300 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1156913009301 active site 1156913009302 catalytic triad [active] 1156913009303 oxyanion hole [active] 1156913009304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913009305 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1156913009306 active site 1156913009307 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1156913009308 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1156913009309 catalytic residues [active] 1156913009310 catalytic nucleophile [active] 1156913009311 Recombinase; Region: Recombinase; pfam07508 1156913009312 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1156913009313 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913009314 Transcription factor WhiB; Region: Whib; pfam02467 1156913009315 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 1156913009316 non-specific DNA binding site [nucleotide binding]; other site 1156913009317 salt bridge; other site 1156913009318 sequence-specific DNA binding site [nucleotide binding]; other site 1156913009319 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913009320 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1156913009321 dimer interface [polypeptide binding]; other site 1156913009322 active site 1156913009323 ADP-ribose binding site [chemical binding]; other site 1156913009324 nudix motif; other site 1156913009325 metal binding site [ion binding]; metal-binding site 1156913009326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913009327 non-specific DNA binding site [nucleotide binding]; other site 1156913009328 salt bridge; other site 1156913009329 sequence-specific DNA binding site [nucleotide binding]; other site 1156913009330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913009331 NACHT domain; Region: NACHT; pfam05729 1156913009332 Walker A motif; other site 1156913009333 ATP binding site [chemical binding]; other site 1156913009334 Walker B motif; other site 1156913009335 HNH endonuclease; Region: HNH_2; pfam13391 1156913009336 Restriction endonuclease; Region: Mrr_cat; pfam04471 1156913009337 AAA domain; Region: AAA_18; pfam13238 1156913009338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1156913009339 Walker A motif; other site 1156913009340 ATP binding site [chemical binding]; other site 1156913009341 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1156913009342 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1156913009343 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913009344 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913009345 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913009346 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913009347 active site 1156913009348 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1156913009349 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1156913009350 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913009351 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1156913009352 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1156913009353 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1156913009354 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1156913009355 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1156913009356 NAD(P) binding site [chemical binding]; other site 1156913009357 catalytic residues [active] 1156913009358 metabolite-proton symporter; Region: 2A0106; TIGR00883 1156913009359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009360 putative substrate translocation pore; other site 1156913009361 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1156913009362 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1156913009363 active site 1156913009364 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913009365 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1156913009366 dimerization interface [polypeptide binding]; other site 1156913009367 putative Zn2+ binding site [ion binding]; other site 1156913009368 putative DNA binding site [nucleotide binding]; other site 1156913009369 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1156913009370 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913009371 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913009372 acyl-CoA synthetase; Validated; Region: PRK06188 1156913009373 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1156913009374 acyl-activating enzyme (AAE) consensus motif; other site 1156913009375 acyl-activating enzyme (AAE) consensus motif; other site 1156913009376 putative AMP binding site [chemical binding]; other site 1156913009377 putative active site [active] 1156913009378 putative CoA binding site [chemical binding]; other site 1156913009379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913009380 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913009381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913009382 NAD(P) binding site [chemical binding]; other site 1156913009383 active site 1156913009384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913009385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913009386 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913009387 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913009388 active site 1156913009389 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 1156913009390 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 1156913009391 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913009392 sugar binding site [chemical binding]; other site 1156913009393 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1156913009394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913009395 DNA-binding site [nucleotide binding]; DNA binding site 1156913009396 FCD domain; Region: FCD; pfam07729 1156913009397 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1156913009398 substrate binding site [chemical binding]; other site 1156913009399 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1156913009400 hydrophobic ligand binding site; other site 1156913009401 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1156913009402 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1156913009403 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1156913009404 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913009405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913009406 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913009407 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1156913009408 putative hydrophobic ligand binding site [chemical binding]; other site 1156913009409 protein interface [polypeptide binding]; other site 1156913009410 gate; other site 1156913009411 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 1156913009412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913009413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913009414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913009415 dimerization interface [polypeptide binding]; other site 1156913009416 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913009417 active site 1156913009418 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1156913009419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1156913009420 dimerization interface [polypeptide binding]; other site 1156913009421 DNA binding residues [nucleotide binding] 1156913009422 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913009423 cleavage site 1156913009424 active site 1156913009425 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913009426 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 1156913009427 sugar binding site [chemical binding]; other site 1156913009428 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913009429 CARDB; Region: CARDB; pfam07705 1156913009430 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1156913009431 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1156913009432 Right handed beta helix region; Region: Beta_helix; pfam13229 1156913009433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913009434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913009435 NAD(P) binding site [chemical binding]; other site 1156913009436 active site 1156913009437 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1156913009438 active site 1156913009439 NTP binding site [chemical binding]; other site 1156913009440 metal binding triad [ion binding]; metal-binding site 1156913009441 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1156913009442 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913009443 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1156913009444 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152 1156913009445 homotrimer interaction site [polypeptide binding]; other site 1156913009446 putative active site [active] 1156913009447 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913009448 MarR family; Region: MarR; pfam01047 1156913009449 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1156913009450 Calx-beta domain; Region: Calx-beta; pfam03160 1156913009451 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1156913009452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913009453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913009454 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1156913009455 flavodoxin; Provisional; Region: PRK06242 1156913009456 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1156913009457 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1156913009458 FAD binding pocket [chemical binding]; other site 1156913009459 FAD binding motif [chemical binding]; other site 1156913009460 phosphate binding motif [ion binding]; other site 1156913009461 NAD binding pocket [chemical binding]; other site 1156913009462 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913009463 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913009464 DNA binding residues [nucleotide binding] 1156913009465 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913009466 dimerization interface [polypeptide binding]; other site 1156913009467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009468 putative substrate translocation pore; other site 1156913009469 acyl-CoA synthetase; Validated; Region: PRK05850 1156913009470 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1156913009471 acyl-activating enzyme (AAE) consensus motif; other site 1156913009472 active site 1156913009473 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913009474 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913009475 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913009476 active site 1156913009477 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913009478 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913009479 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1156913009480 KR domain; Region: KR; pfam08659 1156913009481 putative NADP binding site [chemical binding]; other site 1156913009482 active site 1156913009483 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913009484 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1156913009485 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1156913009486 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1156913009487 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1156913009488 Putative esterase; Region: Esterase; pfam00756 1156913009489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1156913009490 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1156913009491 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1156913009492 tetramer interface [polypeptide binding]; other site 1156913009493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913009494 catalytic residue [active] 1156913009495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1156913009496 YheO-like PAS domain; Region: PAS_6; pfam08348 1156913009497 HTH domain; Region: HTH_22; pfam13309 1156913009498 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1156913009499 homotrimer interaction site [polypeptide binding]; other site 1156913009500 putative active site [active] 1156913009501 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1156913009502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913009503 DNA-binding site [nucleotide binding]; DNA binding site 1156913009504 FCD domain; Region: FCD; pfam07729 1156913009505 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1156913009506 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1156913009507 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1156913009508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913009509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913009510 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913009511 dimerization interface [polypeptide binding]; other site 1156913009512 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913009513 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 1156913009514 active site 1156913009515 catalytic triad [active] 1156913009516 oxyanion hole [active] 1156913009517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913009518 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1156913009519 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913009520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009521 putative substrate translocation pore; other site 1156913009522 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913009523 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 1156913009524 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1156913009525 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1156913009526 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1156913009527 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1156913009528 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1156913009529 putative metal binding site [ion binding]; other site 1156913009530 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1156913009531 NB-ARC domain; Region: NB-ARC; pfam00931 1156913009532 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913009533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913009534 binding surface 1156913009535 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913009536 TPR motif; other site 1156913009537 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913009538 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913009539 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913009540 active site 1156913009541 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1156913009542 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1156913009543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009544 putative substrate translocation pore; other site 1156913009545 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1156913009546 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1156913009547 cyclase homology domain; Region: CHD; cd07302 1156913009548 nucleotidyl binding site; other site 1156913009549 metal binding site [ion binding]; metal-binding site 1156913009550 dimer interface [polypeptide binding]; other site 1156913009551 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1156913009552 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913009553 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 1156913009554 putative FMN binding site [chemical binding]; other site 1156913009555 putative dimer interface [polypeptide binding]; other site 1156913009556 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913009557 cleavage site 1156913009558 active site 1156913009559 substrate binding sites [chemical binding]; other site 1156913009560 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913009561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913009562 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913009563 NAD(P) binding site [chemical binding]; other site 1156913009564 active site 1156913009565 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1156913009566 classical (c) SDRs; Region: SDR_c; cd05233 1156913009567 NAD(P) binding site [chemical binding]; other site 1156913009568 active site 1156913009569 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 1156913009570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913009571 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913009572 salt bridge; other site 1156913009573 non-specific DNA binding site [nucleotide binding]; other site 1156913009574 sequence-specific DNA binding site [nucleotide binding]; other site 1156913009575 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1156913009576 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913009577 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1156913009578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913009579 motif II; other site 1156913009580 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1156913009581 metal ion-dependent adhesion site (MIDAS); other site 1156913009582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913009583 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1156913009584 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1156913009585 Walker A motif; other site 1156913009586 ATP binding site [chemical binding]; other site 1156913009587 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1156913009588 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1156913009589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913009590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913009591 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913009592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913009593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913009594 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913009595 TIGR03086 family protein; Region: TIGR03086 1156913009596 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913009597 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913009598 MarR family; Region: MarR_2; pfam12802 1156913009599 Protein of unknown function (DUF328); Region: DUF328; cl01143 1156913009600 SNF2 Helicase protein; Region: DUF3670; pfam12419 1156913009601 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1156913009602 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913009603 ATP binding site [chemical binding]; other site 1156913009604 putative Mg++ binding site [ion binding]; other site 1156913009605 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913009606 nucleotide binding region [chemical binding]; other site 1156913009607 ATP-binding site [chemical binding]; other site 1156913009608 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1156913009609 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913009610 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1156913009611 substrate binding site [chemical binding]; other site 1156913009612 oxyanion hole (OAH) forming residues; other site 1156913009613 trimer interface [polypeptide binding]; other site 1156913009614 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1156913009615 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1156913009616 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1156913009617 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1156913009618 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1156913009619 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1156913009620 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1156913009621 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913009622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913009623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913009624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913009625 dimerization interface [polypeptide binding]; other site 1156913009626 hypothetical protein; Provisional; Region: PRK07079 1156913009627 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1156913009628 metal binding site [ion binding]; metal-binding site 1156913009629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009630 metabolite-proton symporter; Region: 2A0106; TIGR00883 1156913009631 putative substrate translocation pore; other site 1156913009632 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913009633 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1156913009634 acyl-activating enzyme (AAE) consensus motif; other site 1156913009635 AMP binding site [chemical binding]; other site 1156913009636 active site 1156913009637 CoA binding site [chemical binding]; other site 1156913009638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913009639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913009640 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1156913009641 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913009642 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1156913009643 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1156913009644 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913009645 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913009646 DNA binding site [nucleotide binding] 1156913009647 domain linker motif; other site 1156913009648 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1156913009649 ligand binding site [chemical binding]; other site 1156913009650 dimerization interface [polypeptide binding]; other site 1156913009651 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1156913009652 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913009653 active site 1156913009654 ATP binding site [chemical binding]; other site 1156913009655 substrate binding site [chemical binding]; other site 1156913009656 activation loop (A-loop); other site 1156913009657 Cellulose binding domain; Region: CBM_2; pfam00553 1156913009658 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 1156913009659 active site 1156913009660 catalytic triad [active] 1156913009661 oxyanion hole [active] 1156913009662 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1156913009663 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913009664 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913009665 DNA binding site [nucleotide binding] 1156913009666 domain linker motif; other site 1156913009667 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1156913009668 dimerization interface [polypeptide binding]; other site 1156913009669 ligand binding site [chemical binding]; other site 1156913009670 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1156913009671 Right handed beta helix region; Region: Beta_helix; pfam13229 1156913009672 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 1156913009673 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1156913009674 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913009675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913009676 dimer interface [polypeptide binding]; other site 1156913009677 conserved gate region; other site 1156913009678 putative PBP binding loops; other site 1156913009679 ABC-ATPase subunit interface; other site 1156913009680 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1156913009681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913009682 dimer interface [polypeptide binding]; other site 1156913009683 conserved gate region; other site 1156913009684 putative PBP binding loops; other site 1156913009685 ABC-ATPase subunit interface; other site 1156913009686 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913009687 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913009688 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 1156913009689 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1156913009690 putative ligand binding site [chemical binding]; other site 1156913009691 putative NAD binding site [chemical binding]; other site 1156913009692 catalytic site [active] 1156913009693 PGAP1-like protein; Region: PGAP1; pfam07819 1156913009694 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913009695 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1156913009696 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913009697 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1156913009698 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913009699 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913009700 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913009701 active site 1156913009702 catalytic tetrad [active] 1156913009703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913009704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913009705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913009706 dimerization interface [polypeptide binding]; other site 1156913009707 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913009708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913009709 DNA binding residues [nucleotide binding] 1156913009710 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1156913009711 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913009712 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1156913009713 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1156913009714 Cupin domain; Region: Cupin_2; cl17218 1156913009715 AAA ATPase domain; Region: AAA_16; pfam13191 1156913009716 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913009717 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913009718 DNA binding residues [nucleotide binding] 1156913009719 dimerization interface [polypeptide binding]; other site 1156913009720 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1156913009721 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913009722 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913009723 NTPase; Region: NTPase_1; cl17478 1156913009724 AAA-like domain; Region: AAA_10; pfam12846 1156913009725 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1156913009726 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1156913009727 active site 1156913009728 catalytic site [active] 1156913009729 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913009730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913009731 dimer interface [polypeptide binding]; other site 1156913009732 conserved gate region; other site 1156913009733 putative PBP binding loops; other site 1156913009734 ABC-ATPase subunit interface; other site 1156913009735 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1156913009736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913009737 dimer interface [polypeptide binding]; other site 1156913009738 conserved gate region; other site 1156913009739 putative PBP binding loops; other site 1156913009740 ABC-ATPase subunit interface; other site 1156913009741 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913009742 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1156913009743 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913009744 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913009745 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913009746 DNA binding site [nucleotide binding] 1156913009747 domain linker motif; other site 1156913009748 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 1156913009749 putative dimerization interface [polypeptide binding]; other site 1156913009750 putative ligand binding site [chemical binding]; other site 1156913009751 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913009752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009753 putative substrate translocation pore; other site 1156913009754 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1156913009755 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1156913009756 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 1156913009757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009758 putative substrate translocation pore; other site 1156913009759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913009760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913009761 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1156913009762 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1156913009763 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1156913009764 shikimate binding site; other site 1156913009765 NAD(P) binding site [chemical binding]; other site 1156913009766 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1156913009767 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1156913009768 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1156913009769 dimer interface [polypeptide binding]; other site 1156913009770 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1156913009771 active site 1156913009772 Fe binding site [ion binding]; other site 1156913009773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913009774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913009775 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1156913009776 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913009777 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1156913009778 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913009779 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1156913009780 transmembrane helices; other site 1156913009781 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1156913009782 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 1156913009783 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913009784 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1156913009785 aspartate aminotransferase; Provisional; Region: PRK05764 1156913009786 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913009787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913009788 homodimer interface [polypeptide binding]; other site 1156913009789 catalytic residue [active] 1156913009790 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913009791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913009792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913009793 WHG domain; Region: WHG; pfam13305 1156913009794 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1156913009795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913009796 DNA-binding site [nucleotide binding]; DNA binding site 1156913009797 FCD domain; Region: FCD; pfam07729 1156913009798 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 1156913009799 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1156913009800 acyl-CoA synthetase; Validated; Region: PRK07787 1156913009801 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913009802 acyl-activating enzyme (AAE) consensus motif; other site 1156913009803 AMP binding site [chemical binding]; other site 1156913009804 active site 1156913009805 CoA binding site [chemical binding]; other site 1156913009806 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1156913009807 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1156913009808 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1156913009809 active site 1156913009810 catalytic triad [active] 1156913009811 oxyanion hole [active] 1156913009812 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1156913009813 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913009814 conserved cys residue [active] 1156913009815 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913009816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913009817 NAD(P) binding site [chemical binding]; other site 1156913009818 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1156913009819 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913009820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913009821 active site 1156913009822 phosphorylation site [posttranslational modification] 1156913009823 intermolecular recognition site; other site 1156913009824 dimerization interface [polypeptide binding]; other site 1156913009825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913009826 DNA binding site [nucleotide binding] 1156913009827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913009828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913009829 dimerization interface [polypeptide binding]; other site 1156913009830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913009831 dimer interface [polypeptide binding]; other site 1156913009832 phosphorylation site [posttranslational modification] 1156913009833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913009834 ATP binding site [chemical binding]; other site 1156913009835 Mg2+ binding site [ion binding]; other site 1156913009836 G-X-G motif; other site 1156913009837 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1156913009838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913009839 NAD(P) binding site [chemical binding]; other site 1156913009840 active site 1156913009841 isochorismate synthase DhbC; Validated; Region: PRK06923 1156913009842 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1156913009843 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1156913009844 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1156913009845 acyl-activating enzyme (AAE) consensus motif; other site 1156913009846 active site 1156913009847 AMP binding site [chemical binding]; other site 1156913009848 substrate binding site [chemical binding]; other site 1156913009849 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1156913009850 Isochorismatase family; Region: Isochorismatase; pfam00857 1156913009851 catalytic triad [active] 1156913009852 conserved cis-peptide bond; other site 1156913009853 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1156913009854 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1156913009855 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1156913009856 FAD binding pocket [chemical binding]; other site 1156913009857 FAD binding motif [chemical binding]; other site 1156913009858 phosphate binding motif [ion binding]; other site 1156913009859 NAD binding pocket [chemical binding]; other site 1156913009860 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1156913009861 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1156913009862 intersubunit interface [polypeptide binding]; other site 1156913009863 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1156913009864 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913009865 ABC-ATPase subunit interface; other site 1156913009866 dimer interface [polypeptide binding]; other site 1156913009867 putative PBP binding regions; other site 1156913009868 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1156913009869 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1156913009870 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913009871 ABC-ATPase subunit interface; other site 1156913009872 dimer interface [polypeptide binding]; other site 1156913009873 putative PBP binding regions; other site 1156913009874 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1156913009875 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1156913009876 Walker A/P-loop; other site 1156913009877 ATP binding site [chemical binding]; other site 1156913009878 Q-loop/lid; other site 1156913009879 ABC transporter signature motif; other site 1156913009880 Walker B; other site 1156913009881 D-loop; other site 1156913009882 H-loop/switch region; other site 1156913009883 Condensation domain; Region: Condensation; pfam00668 1156913009884 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913009885 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913009886 acyl-activating enzyme (AAE) consensus motif; other site 1156913009887 AMP binding site [chemical binding]; other site 1156913009888 Condensation domain; Region: Condensation; pfam00668 1156913009889 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913009890 Condensation domain; Region: Condensation; pfam00668 1156913009891 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913009892 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913009893 acyl-activating enzyme (AAE) consensus motif; other site 1156913009894 AMP binding site [chemical binding]; other site 1156913009895 Condensation domain; Region: Condensation; pfam00668 1156913009896 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913009897 Condensation domain; Region: Condensation; pfam00668 1156913009898 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913009899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009900 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913009901 putative substrate translocation pore; other site 1156913009902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913009903 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1156913009904 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1156913009905 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 1156913009906 putative hydrophobic ligand binding site [chemical binding]; other site 1156913009907 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913009908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913009909 active site 1156913009910 phosphorylation site [posttranslational modification] 1156913009911 intermolecular recognition site; other site 1156913009912 dimerization interface [polypeptide binding]; other site 1156913009913 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1156913009914 DNA binding residues [nucleotide binding] 1156913009915 dimerization interface [polypeptide binding]; other site 1156913009916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1156913009917 ATP binding site [chemical binding]; other site 1156913009918 G-X-G motif; other site 1156913009919 translocation protein TolB; Provisional; Region: tolB; PRK01029 1156913009920 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913009921 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913009922 active site 1156913009923 metal binding site [ion binding]; metal-binding site 1156913009924 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913009925 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913009926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913009927 non-specific DNA binding site [nucleotide binding]; other site 1156913009928 salt bridge; other site 1156913009929 sequence-specific DNA binding site [nucleotide binding]; other site 1156913009930 TIGR03943 family protein; Region: TIGR03943 1156913009931 Predicted permease; Region: DUF318; cl17795 1156913009932 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1156913009933 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1156913009934 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1156913009935 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1156913009936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913009937 DNA-binding site [nucleotide binding]; DNA binding site 1156913009938 FCD domain; Region: FCD; pfam07729 1156913009939 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913009940 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913009941 NAD(P) binding site [chemical binding]; other site 1156913009942 catalytic residues [active] 1156913009943 choline dehydrogenase; Validated; Region: PRK02106 1156913009944 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1156913009945 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1156913009946 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913009947 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913009948 active site 1156913009949 catalytic tetrad [active] 1156913009950 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 1156913009951 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1156913009952 catalytic Zn binding site [ion binding]; other site 1156913009953 structural Zn binding site [ion binding]; other site 1156913009954 tetramer interface [polypeptide binding]; other site 1156913009955 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913009956 Amidohydrolase; Region: Amidohydro_4; pfam13147 1156913009957 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913009958 active site 1156913009959 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913009960 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913009961 active site 1156913009962 catalytic tetrad [active] 1156913009963 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1156913009964 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913009965 nucleophilic elbow; other site 1156913009966 catalytic triad; other site 1156913009967 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1156913009968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913009969 dimer interface [polypeptide binding]; other site 1156913009970 conserved gate region; other site 1156913009971 putative PBP binding loops; other site 1156913009972 ABC-ATPase subunit interface; other site 1156913009973 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1156913009974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913009975 dimer interface [polypeptide binding]; other site 1156913009976 conserved gate region; other site 1156913009977 putative PBP binding loops; other site 1156913009978 ABC-ATPase subunit interface; other site 1156913009979 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1156913009980 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1156913009981 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1156913009982 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913009983 Walker A/P-loop; other site 1156913009984 ATP binding site [chemical binding]; other site 1156913009985 Q-loop/lid; other site 1156913009986 ABC transporter signature motif; other site 1156913009987 Walker B; other site 1156913009988 D-loop; other site 1156913009989 H-loop/switch region; other site 1156913009990 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1156913009991 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913009992 Walker A/P-loop; other site 1156913009993 ATP binding site [chemical binding]; other site 1156913009994 Q-loop/lid; other site 1156913009995 ABC transporter signature motif; other site 1156913009996 Walker B; other site 1156913009997 D-loop; other site 1156913009998 H-loop/switch region; other site 1156913009999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1156913010000 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1156913010001 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1156913010002 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913010003 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913010004 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1156913010005 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1156913010006 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1156913010007 active site 1156913010008 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1156913010009 tyramine oxidase; Provisional; Region: tynA; PRK11504 1156913010010 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1156913010011 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1156913010012 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1156913010013 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913010014 classical (c) SDRs; Region: SDR_c; cd05233 1156913010015 NAD(P) binding site [chemical binding]; other site 1156913010016 active site 1156913010017 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913010018 classical (c) SDRs; Region: SDR_c; cd05233 1156913010019 NAD(P) binding site [chemical binding]; other site 1156913010020 active site 1156913010021 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1156913010022 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1156913010023 Walker A/P-loop; other site 1156913010024 ATP binding site [chemical binding]; other site 1156913010025 Q-loop/lid; other site 1156913010026 ABC transporter signature motif; other site 1156913010027 Walker B; other site 1156913010028 D-loop; other site 1156913010029 H-loop/switch region; other site 1156913010030 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1156913010031 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1156913010032 TM-ABC transporter signature motif; other site 1156913010033 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1156913010034 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1156913010035 Walker A/P-loop; other site 1156913010036 ATP binding site [chemical binding]; other site 1156913010037 Q-loop/lid; other site 1156913010038 ABC transporter signature motif; other site 1156913010039 Walker B; other site 1156913010040 D-loop; other site 1156913010041 H-loop/switch region; other site 1156913010042 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1156913010043 TM-ABC transporter signature motif; other site 1156913010044 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1156913010045 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1156913010046 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1156913010047 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1156913010048 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1156913010049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913010050 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913010051 putative DNA binding site [nucleotide binding]; other site 1156913010052 dimerization interface [polypeptide binding]; other site 1156913010053 putative Zn2+ binding site [ion binding]; other site 1156913010054 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 1156913010055 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913010056 Cytochrome P450; Region: p450; cl12078 1156913010057 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1156913010058 Domain of unknown function DUF21; Region: DUF21; pfam01595 1156913010059 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1156913010060 Transporter associated domain; Region: CorC_HlyC; smart01091 1156913010061 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1156913010062 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913010063 Predicted ATPase [General function prediction only]; Region: COG3903 1156913010064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1156913010065 binding surface 1156913010066 TPR motif; other site 1156913010067 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913010068 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913010069 DNA binding residues [nucleotide binding] 1156913010070 dimerization interface [polypeptide binding]; other site 1156913010071 Histidine kinase; Region: HisKA_3; pfam07730 1156913010072 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913010073 ATP binding site [chemical binding]; other site 1156913010074 Mg2+ binding site [ion binding]; other site 1156913010075 G-X-G motif; other site 1156913010076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913010077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913010078 active site 1156913010079 phosphorylation site [posttranslational modification] 1156913010080 intermolecular recognition site; other site 1156913010081 dimerization interface [polypeptide binding]; other site 1156913010082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913010083 DNA binding residues [nucleotide binding] 1156913010084 dimerization interface [polypeptide binding]; other site 1156913010085 RibD C-terminal domain; Region: RibD_C; pfam01872 1156913010086 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1156913010087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913010088 Walker A/P-loop; other site 1156913010089 ATP binding site [chemical binding]; other site 1156913010090 Q-loop/lid; other site 1156913010091 ABC transporter signature motif; other site 1156913010092 Walker B; other site 1156913010093 D-loop; other site 1156913010094 H-loop/switch region; other site 1156913010095 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1156913010096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1156913010097 ATP binding site [chemical binding]; other site 1156913010098 Mg2+ binding site [ion binding]; other site 1156913010099 G-X-G motif; other site 1156913010100 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1156913010101 anti sigma factor interaction site; other site 1156913010102 regulatory phosphorylation site [posttranslational modification]; other site 1156913010103 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1156913010104 anti sigma factor interaction site; other site 1156913010105 regulatory phosphorylation site [posttranslational modification]; other site 1156913010106 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913010107 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913010108 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1156913010109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913010110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913010111 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1156913010112 dimerization interface [polypeptide binding]; other site 1156913010113 substrate binding pocket [chemical binding]; other site 1156913010114 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1156913010115 proline aminopeptidase P II; Provisional; Region: PRK10879 1156913010116 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1156913010117 active site 1156913010118 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913010119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913010120 sequence-specific DNA binding site [nucleotide binding]; other site 1156913010121 salt bridge; other site 1156913010122 Cupin domain; Region: Cupin_2; pfam07883 1156913010123 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1156913010124 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1156913010125 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1156913010126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1156913010127 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1156913010128 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1156913010129 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1156913010130 inhibitor site; inhibition site 1156913010131 active site 1156913010132 dimer interface [polypeptide binding]; other site 1156913010133 catalytic residue [active] 1156913010134 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1156913010135 Proline racemase; Region: Pro_racemase; pfam05544 1156913010136 amino acid transporter; Region: 2A0306; TIGR00909 1156913010137 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1156913010138 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1156913010139 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1156913010140 dimer interface [polypeptide binding]; other site 1156913010141 NADP binding site [chemical binding]; other site 1156913010142 catalytic residues [active] 1156913010143 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1156913010144 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913010145 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1156913010146 active site 1156913010147 GAF domain; Region: GAF_3; pfam13492 1156913010148 GAF domain; Region: GAF_2; pfam13185 1156913010149 benzoate transport; Region: 2A0115; TIGR00895 1156913010150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010151 putative substrate translocation pore; other site 1156913010152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010153 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1156913010154 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1156913010155 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1156913010156 putative active site [active] 1156913010157 VanZ like family; Region: VanZ; pfam04892 1156913010158 RDD family; Region: RDD; pfam06271 1156913010159 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1156913010160 Peptidase family M48; Region: Peptidase_M48; cl12018 1156913010161 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1156913010162 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1156913010163 NlpC/P60 family; Region: NLPC_P60; pfam00877 1156913010164 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1156913010165 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1156913010166 dimer interface [polypeptide binding]; other site 1156913010167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913010168 catalytic residue [active] 1156913010169 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1156913010170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010171 putative substrate translocation pore; other site 1156913010172 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1156913010173 putative active site [active] 1156913010174 redox center [active] 1156913010175 Thioredoxin; Region: Thioredoxin_4; pfam13462 1156913010176 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1156913010177 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913010178 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913010179 active site 1156913010180 metal binding site [ion binding]; metal-binding site 1156913010181 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1156913010182 putative catalytic site [active] 1156913010183 putative metal binding site [ion binding]; other site 1156913010184 putative phosphate binding site [ion binding]; other site 1156913010185 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1156913010186 active site 1156913010187 ChaB; Region: ChaB; pfam06150 1156913010188 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1156913010189 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 1156913010190 D-glutamate deacylase; Validated; Region: PRK09061 1156913010191 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913010192 active site 1156913010193 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913010194 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1156913010195 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913010196 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913010197 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913010198 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1156913010199 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1156913010200 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1156913010201 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1156913010202 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1156913010203 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1156913010204 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1156913010205 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1156913010206 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1156913010207 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913010208 active site 1156913010209 CAAX protease self-immunity; Region: Abi; pfam02517 1156913010210 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913010211 Cytochrome P450; Region: p450; cl12078 1156913010212 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913010213 dimerization interface [polypeptide binding]; other site 1156913010214 putative DNA binding site [nucleotide binding]; other site 1156913010215 putative Zn2+ binding site [ion binding]; other site 1156913010216 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913010217 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913010218 NB-ARC domain; Region: NB-ARC; pfam00931 1156913010219 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913010220 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913010221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913010222 binding surface 1156913010223 TPR motif; other site 1156913010224 TPR repeat; Region: TPR_11; pfam13414 1156913010225 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913010226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010227 putative substrate translocation pore; other site 1156913010228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010229 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1156913010230 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1156913010231 CBD_II domain; Region: CBD_II; smart00637 1156913010232 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913010233 Interdomain contacts; other site 1156913010234 Cytokine receptor motif; other site 1156913010235 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913010236 Interdomain contacts; other site 1156913010237 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1156913010238 Glyco_18 domain; Region: Glyco_18; smart00636 1156913010239 active site 1156913010240 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1156913010241 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913010242 substrate binding site [chemical binding]; other site 1156913010243 oxyanion hole (OAH) forming residues; other site 1156913010244 trimer interface [polypeptide binding]; other site 1156913010245 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 1156913010246 PaaX-like protein; Region: PaaX; pfam07848 1156913010247 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1156913010248 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1156913010249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913010250 Walker A/P-loop; other site 1156913010251 ATP binding site [chemical binding]; other site 1156913010252 Q-loop/lid; other site 1156913010253 ABC transporter signature motif; other site 1156913010254 Walker B; other site 1156913010255 D-loop; other site 1156913010256 H-loop/switch region; other site 1156913010257 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913010258 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913010259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913010260 dimer interface [polypeptide binding]; other site 1156913010261 conserved gate region; other site 1156913010262 putative PBP binding loops; other site 1156913010263 ABC-ATPase subunit interface; other site 1156913010264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913010265 putative PBP binding loops; other site 1156913010266 dimer interface [polypeptide binding]; other site 1156913010267 ABC-ATPase subunit interface; other site 1156913010268 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913010269 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913010270 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1156913010271 Melibiase; Region: Melibiase; pfam02065 1156913010272 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1156913010273 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1156913010274 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913010275 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913010276 DNA binding residues [nucleotide binding] 1156913010277 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1156913010278 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1156913010279 active site 1156913010280 substrate binding site [chemical binding]; other site 1156913010281 cosubstrate binding site; other site 1156913010282 catalytic site [active] 1156913010283 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 1156913010284 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1156913010285 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913010286 Condensation domain; Region: Condensation; pfam00668 1156913010287 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913010288 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913010289 acyl-activating enzyme (AAE) consensus motif; other site 1156913010290 AMP binding site [chemical binding]; other site 1156913010291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913010292 Condensation domain; Region: Condensation; pfam00668 1156913010293 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913010294 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913010295 acyl-activating enzyme (AAE) consensus motif; other site 1156913010296 AMP binding site [chemical binding]; other site 1156913010297 Condensation domain; Region: Condensation; pfam00668 1156913010298 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913010299 Condensation domain; Region: Condensation; pfam00668 1156913010300 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913010301 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913010302 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913010303 acyl-activating enzyme (AAE) consensus motif; other site 1156913010304 AMP binding site [chemical binding]; other site 1156913010305 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913010306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913010307 S-adenosylmethionine binding site [chemical binding]; other site 1156913010308 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913010309 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913010310 Condensation domain; Region: Condensation; pfam00668 1156913010311 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913010312 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913010313 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913010314 acyl-activating enzyme (AAE) consensus motif; other site 1156913010315 AMP binding site [chemical binding]; other site 1156913010316 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913010317 Condensation domain; Region: Condensation; pfam00668 1156913010318 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913010319 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913010320 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913010321 acyl-activating enzyme (AAE) consensus motif; other site 1156913010322 AMP binding site [chemical binding]; other site 1156913010323 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913010324 Condensation domain; Region: Condensation; pfam00668 1156913010325 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913010326 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913010327 acyl-activating enzyme (AAE) consensus motif; other site 1156913010328 AMP binding site [chemical binding]; other site 1156913010329 Condensation domain; Region: Condensation; pfam00668 1156913010330 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913010331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1156913010332 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913010333 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913010334 active site 1156913010335 metal binding site [ion binding]; metal-binding site 1156913010336 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 1156913010337 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1156913010338 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1156913010339 intersubunit interface [polypeptide binding]; other site 1156913010340 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913010341 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913010342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913010343 Walker A/P-loop; other site 1156913010344 ATP binding site [chemical binding]; other site 1156913010345 Q-loop/lid; other site 1156913010346 ABC transporter signature motif; other site 1156913010347 Walker B; other site 1156913010348 D-loop; other site 1156913010349 H-loop/switch region; other site 1156913010350 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913010351 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913010352 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1156913010353 Walker A/P-loop; other site 1156913010354 ATP binding site [chemical binding]; other site 1156913010355 Q-loop/lid; other site 1156913010356 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1156913010357 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913010358 ABC-ATPase subunit interface; other site 1156913010359 dimer interface [polypeptide binding]; other site 1156913010360 putative PBP binding regions; other site 1156913010361 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1156913010362 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913010363 ABC-ATPase subunit interface; other site 1156913010364 dimer interface [polypeptide binding]; other site 1156913010365 putative PBP binding regions; other site 1156913010366 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1156913010367 DinB superfamily; Region: DinB_2; pfam12867 1156913010368 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1156913010369 Homeodomain-like domain; Region: HTH_23; cl17451 1156913010370 Winged helix-turn helix; Region: HTH_29; pfam13551 1156913010371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1156913010372 Integrase core domain; Region: rve; pfam00665 1156913010373 Integrase core domain; Region: rve_3; pfam13683 1156913010374 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1156913010375 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1156913010376 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1156913010377 active site 1156913010378 dimer interface [polypeptide binding]; other site 1156913010379 non-prolyl cis peptide bond; other site 1156913010380 insertion regions; other site 1156913010381 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913010382 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1156913010383 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913010384 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1156913010385 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1156913010386 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1156913010387 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1156913010388 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1156913010389 active site 1156913010390 catalytic residues [active] 1156913010391 metal binding site [ion binding]; metal-binding site 1156913010392 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1156913010393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913010394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913010395 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1156913010396 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913010397 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1156913010398 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1156913010399 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 1156913010400 putative catalytic site [active] 1156913010401 metal binding site A [ion binding]; metal-binding site 1156913010402 phosphate binding site [ion binding]; other site 1156913010403 metal binding site C [ion binding]; metal-binding site 1156913010404 metal binding site B [ion binding]; metal-binding site 1156913010405 MFS/sugar transport protein; Region: MFS_2; pfam13347 1156913010406 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1156913010407 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1156913010408 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1156913010409 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913010410 catalytic residue [active] 1156913010411 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1156913010412 hydrophobic ligand binding site; other site 1156913010413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913010414 dimerization interface [polypeptide binding]; other site 1156913010415 putative DNA binding site [nucleotide binding]; other site 1156913010416 putative Zn2+ binding site [ion binding]; other site 1156913010417 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1156913010418 acyl-CoA synthetase; Validated; Region: PRK06188 1156913010419 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913010420 active site 1156913010421 CoA binding site [chemical binding]; other site 1156913010422 AMP binding site [chemical binding]; other site 1156913010423 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1156913010424 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1156913010425 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1156913010426 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1156913010427 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1156913010428 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1156913010429 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1156913010430 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1156913010431 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1156913010432 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1156913010433 30S ribosomal protein S18; Provisional; Region: PRK13401 1156913010434 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1156913010435 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1156913010436 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1156913010437 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1156913010438 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1156913010439 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1156913010440 homodimer interface [polypeptide binding]; other site 1156913010441 active site 1156913010442 SAM binding site [chemical binding]; other site 1156913010443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913010444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1156913010445 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913010446 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913010447 enoyl-CoA hydratase; Provisional; Region: PRK06142 1156913010448 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913010449 substrate binding site [chemical binding]; other site 1156913010450 oxyanion hole (OAH) forming residues; other site 1156913010451 trimer interface [polypeptide binding]; other site 1156913010452 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1156913010453 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913010454 acyl-activating enzyme (AAE) consensus motif; other site 1156913010455 AMP binding site [chemical binding]; other site 1156913010456 active site 1156913010457 CoA binding site [chemical binding]; other site 1156913010458 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913010459 Peptidase M15; Region: Peptidase_M15_3; pfam08291 1156913010460 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1156913010461 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1156913010462 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1156913010463 HSP70 interaction site [polypeptide binding]; other site 1156913010464 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1156913010465 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1156913010466 lipoyl attachment site [posttranslational modification]; other site 1156913010467 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1156913010468 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1156913010469 phosphopeptide binding site; other site 1156913010470 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1156913010471 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1156913010472 DNA binding residues [nucleotide binding] 1156913010473 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1156913010474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913010475 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1156913010476 DNA binding residues [nucleotide binding] 1156913010477 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913010478 putative dimer interface [polypeptide binding]; other site 1156913010479 glycine dehydrogenase; Provisional; Region: PRK05367 1156913010480 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1156913010481 tetramer interface [polypeptide binding]; other site 1156913010482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913010483 catalytic residue [active] 1156913010484 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1156913010485 tetramer interface [polypeptide binding]; other site 1156913010486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913010487 catalytic residue [active] 1156913010488 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913010489 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913010490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913010491 non-specific DNA binding site [nucleotide binding]; other site 1156913010492 salt bridge; other site 1156913010493 sequence-specific DNA binding site [nucleotide binding]; other site 1156913010494 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913010495 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913010496 active site 1156913010497 catalytic tetrad [active] 1156913010498 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1156913010499 Domain of unknown function DUF21; Region: DUF21; pfam01595 1156913010500 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1156913010501 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1156913010502 Domain of unknown function DUF21; Region: DUF21; pfam01595 1156913010503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1156913010504 Transporter associated domain; Region: CorC_HlyC; smart01091 1156913010505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913010506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913010507 Bacterial transcriptional repressor; Region: TetR; pfam13972 1156913010508 EspG family; Region: ESX-1_EspG; pfam14011 1156913010509 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1156913010510 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913010511 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1156913010512 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1156913010513 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1156913010514 NAD(P) binding site [chemical binding]; other site 1156913010515 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913010516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913010517 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1156913010518 putative dimerization interface [polypeptide binding]; other site 1156913010519 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1156913010520 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1156913010521 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1156913010522 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1156913010523 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1156913010524 putative active site [active] 1156913010525 putative dimer interface [polypeptide binding]; other site 1156913010526 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1156913010527 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1156913010528 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1156913010529 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913010530 Chlorite dismutase; Region: Chlor_dismutase; cl01280 1156913010531 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1156913010532 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913010533 putative NAD(P) binding site [chemical binding]; other site 1156913010534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010535 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913010536 putative substrate translocation pore; other site 1156913010537 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913010538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913010539 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1156913010540 putative substrate binding pocket [chemical binding]; other site 1156913010541 putative dimerization interface [polypeptide binding]; other site 1156913010542 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1156913010543 MgtC family; Region: MgtC; pfam02308 1156913010544 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913010545 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913010546 aconitate hydratase; Validated; Region: PRK09277 1156913010547 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1156913010548 substrate binding site [chemical binding]; other site 1156913010549 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1156913010550 ligand binding site [chemical binding]; other site 1156913010551 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1156913010552 substrate binding site [chemical binding]; other site 1156913010553 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1156913010554 NlpC/P60 family; Region: NLPC_P60; pfam00877 1156913010555 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1156913010556 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 1156913010557 active site 1156913010558 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1156913010559 MoxR-like ATPases [General function prediction only]; Region: COG0714 1156913010560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913010561 ATP binding site [chemical binding]; other site 1156913010562 Walker A motif; other site 1156913010563 Walker B motif; other site 1156913010564 arginine finger; other site 1156913010565 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1156913010566 Protein of unknown function DUF58; Region: DUF58; pfam01882 1156913010567 hypothetical protein; Provisional; Region: PRK13685 1156913010568 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1156913010569 metal ion-dependent adhesion site (MIDAS); other site 1156913010570 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1156913010571 PhoD-like phosphatase; Region: PhoD; pfam09423 1156913010572 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1156913010573 putative active site [active] 1156913010574 putative metal binding site [ion binding]; other site 1156913010575 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1156913010576 active site 1156913010577 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1156913010578 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1156913010579 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1156913010580 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1156913010581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913010582 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913010583 dimerization interface [polypeptide binding]; other site 1156913010584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913010585 dimer interface [polypeptide binding]; other site 1156913010586 phosphorylation site [posttranslational modification] 1156913010587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913010588 ATP binding site [chemical binding]; other site 1156913010589 Mg2+ binding site [ion binding]; other site 1156913010590 G-X-G motif; other site 1156913010591 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913010592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913010593 active site 1156913010594 phosphorylation site [posttranslational modification] 1156913010595 intermolecular recognition site; other site 1156913010596 dimerization interface [polypeptide binding]; other site 1156913010597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913010598 DNA binding site [nucleotide binding] 1156913010599 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1156913010600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010602 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1156913010603 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1156913010604 NAD(P) binding site [chemical binding]; other site 1156913010605 homotetramer interface [polypeptide binding]; other site 1156913010606 homodimer interface [polypeptide binding]; other site 1156913010607 active site 1156913010608 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1156913010609 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1156913010610 NAD binding site [chemical binding]; other site 1156913010611 homotetramer interface [polypeptide binding]; other site 1156913010612 homodimer interface [polypeptide binding]; other site 1156913010613 substrate binding site [chemical binding]; other site 1156913010614 active site 1156913010615 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913010616 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1156913010617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010618 putative substrate translocation pore; other site 1156913010619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913010620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913010621 ferrochelatase; Reviewed; Region: hemH; PRK00035 1156913010622 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1156913010623 C-terminal domain interface [polypeptide binding]; other site 1156913010624 active site 1156913010625 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1156913010626 active site 1156913010627 N-terminal domain interface [polypeptide binding]; other site 1156913010628 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1156913010629 DNA-binding site [nucleotide binding]; DNA binding site 1156913010630 RNA-binding motif; other site 1156913010631 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1156913010632 DNA-binding site [nucleotide binding]; DNA binding site 1156913010633 RNA-binding motif; other site 1156913010634 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1156913010635 DNA-binding site [nucleotide binding]; DNA binding site 1156913010636 RNA-binding motif; other site 1156913010637 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1156913010638 DNA-binding site [nucleotide binding]; DNA binding site 1156913010639 RNA-binding motif; other site 1156913010640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913010641 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913010642 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1156913010643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913010644 Walker A/P-loop; other site 1156913010645 ATP binding site [chemical binding]; other site 1156913010646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1156913010647 Walker B motif; other site 1156913010648 arginine finger; other site 1156913010649 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1156913010650 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1156913010651 metal ion-dependent adhesion site (MIDAS); other site 1156913010652 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1156913010653 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913010654 DNA binding residues [nucleotide binding] 1156913010655 dimer interface [polypeptide binding]; other site 1156913010656 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1156913010657 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1156913010658 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1156913010659 active site 1156913010660 HIGH motif; other site 1156913010661 nucleotide binding site [chemical binding]; other site 1156913010662 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1156913010663 active site 1156913010664 KMSKS motif; other site 1156913010665 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1156913010666 putative tRNA binding surface [nucleotide binding]; other site 1156913010667 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1156913010668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913010669 Walker A/P-loop; other site 1156913010670 ATP binding site [chemical binding]; other site 1156913010671 Q-loop/lid; other site 1156913010672 ABC transporter signature motif; other site 1156913010673 Walker B; other site 1156913010674 D-loop; other site 1156913010675 H-loop/switch region; other site 1156913010676 ABC transporter; Region: ABC_tran_2; pfam12848 1156913010677 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913010678 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913010679 MarR family; Region: MarR; pfam01047 1156913010680 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913010681 dimerization interface [polypeptide binding]; other site 1156913010682 putative DNA binding site [nucleotide binding]; other site 1156913010683 putative Zn2+ binding site [ion binding]; other site 1156913010684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010685 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913010686 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913010687 active site 1156913010688 metal binding site [ion binding]; metal-binding site 1156913010689 PAC2 family; Region: PAC2; pfam09754 1156913010690 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1156913010691 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1156913010692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913010693 motif II; other site 1156913010694 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1156913010695 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1156913010696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913010697 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1156913010698 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1156913010699 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1156913010700 minor groove reading motif; other site 1156913010701 helix-hairpin-helix signature motif; other site 1156913010702 substrate binding pocket [chemical binding]; other site 1156913010703 active site 1156913010704 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1156913010705 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1156913010706 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1156913010707 DNA binding site [nucleotide binding] 1156913010708 active site 1156913010709 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1156913010710 homodimer interface [polypeptide binding]; other site 1156913010711 putative metal binding site [ion binding]; other site 1156913010712 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1156913010713 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1156913010714 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1156913010715 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1156913010716 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1156913010717 P-loop; other site 1156913010718 Magnesium ion binding site [ion binding]; other site 1156913010719 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1156913010720 Magnesium ion binding site [ion binding]; other site 1156913010721 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1156913010722 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1156913010723 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1156913010724 active site 1156913010725 putative substrate binding region [chemical binding]; other site 1156913010726 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1156913010727 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1156913010728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913010729 S-adenosylmethionine binding site [chemical binding]; other site 1156913010730 proteasome ATPase; Region: pup_AAA; TIGR03689 1156913010731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913010732 Walker A motif; other site 1156913010733 ATP binding site [chemical binding]; other site 1156913010734 Walker B motif; other site 1156913010735 arginine finger; other site 1156913010736 EamA-like transporter family; Region: EamA; pfam00892 1156913010737 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913010738 active site 1156913010739 catalytic tetrad [active] 1156913010740 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1156913010741 nudix motif; other site 1156913010742 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1156913010743 Pup-like protein; Region: Pup; pfam05639 1156913010744 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1156913010745 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1156913010746 active site 1156913010747 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1156913010748 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1156913010749 active site 1156913010750 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1156913010751 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1156913010752 putative sugar binding sites [chemical binding]; other site 1156913010753 Q-X-W motif; other site 1156913010754 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913010755 putative DNA binding site [nucleotide binding]; other site 1156913010756 dimerization interface [polypeptide binding]; other site 1156913010757 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913010758 putative Zn2+ binding site [ion binding]; other site 1156913010759 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1156913010760 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1156913010761 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1156913010762 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1156913010763 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913010764 dimerization interface [polypeptide binding]; other site 1156913010765 putative DNA binding site [nucleotide binding]; other site 1156913010766 putative Zn2+ binding site [ion binding]; other site 1156913010767 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1156913010768 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1156913010769 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1156913010770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913010771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913010772 NAD(P) binding site [chemical binding]; other site 1156913010773 active site 1156913010774 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1156913010775 putative hydrophobic ligand binding site [chemical binding]; other site 1156913010776 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1156913010777 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913010778 putative NAD(P) binding site [chemical binding]; other site 1156913010779 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913010780 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913010781 Predicted transcriptional regulator [Transcription]; Region: COG2378 1156913010782 WYL domain; Region: WYL; pfam13280 1156913010783 Predicted transcriptional regulator [Transcription]; Region: COG2378 1156913010784 WYL domain; Region: WYL; pfam13280 1156913010785 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1156913010786 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1156913010787 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1156913010788 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1156913010789 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1156913010790 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1156913010791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913010792 ATP binding site [chemical binding]; other site 1156913010793 putative Mg++ binding site [ion binding]; other site 1156913010794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913010795 nucleotide binding region [chemical binding]; other site 1156913010796 ATP-binding site [chemical binding]; other site 1156913010797 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1156913010798 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1156913010799 hypothetical protein; Provisional; Region: PRK01346 1156913010800 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1156913010801 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1156913010802 hypothetical protein; Provisional; Region: PRK01346 1156913010803 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1156913010804 Pirin-related protein [General function prediction only]; Region: COG1741 1156913010805 Pirin; Region: Pirin; pfam02678 1156913010806 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1156913010807 5'-3' exonuclease; Region: 53EXOc; smart00475 1156913010808 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1156913010809 active site 1156913010810 metal binding site 1 [ion binding]; metal-binding site 1156913010811 putative 5' ssDNA interaction site; other site 1156913010812 metal binding site 3; metal-binding site 1156913010813 metal binding site 2 [ion binding]; metal-binding site 1156913010814 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1156913010815 putative DNA binding site [nucleotide binding]; other site 1156913010816 putative metal binding site [ion binding]; other site 1156913010817 Predicted flavoprotein [General function prediction only]; Region: COG0431 1156913010818 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1156913010819 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913010820 dimerization interface [polypeptide binding]; other site 1156913010821 putative DNA binding site [nucleotide binding]; other site 1156913010822 putative Zn2+ binding site [ion binding]; other site 1156913010823 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913010824 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1156913010825 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1156913010826 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1156913010827 active site 1156913010828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913010829 putative DNA binding site [nucleotide binding]; other site 1156913010830 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1156913010831 putative Zn2+ binding site [ion binding]; other site 1156913010832 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913010833 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1156913010834 active site 1156913010835 catalytic triad [active] 1156913010836 oxyanion hole [active] 1156913010837 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1156913010838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913010839 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1156913010840 dimerization interface [polypeptide binding]; other site 1156913010841 substrate binding pocket [chemical binding]; other site 1156913010842 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1156913010843 NADP binding site [chemical binding]; other site 1156913010844 active site 1156913010845 steroid binding site; other site 1156913010846 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 1156913010847 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1156913010848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1156913010849 hypothetical protein; Provisional; Region: PRK07206 1156913010850 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1156913010851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010852 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913010853 putative substrate translocation pore; other site 1156913010854 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913010855 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1156913010856 hypothetical protein; Provisional; Region: PRK07906 1156913010857 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1156913010858 putative metal binding site [ion binding]; other site 1156913010859 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 1156913010860 SxDxEG motif; other site 1156913010861 active site 1156913010862 metal binding site [ion binding]; metal-binding site 1156913010863 homopentamer interface [polypeptide binding]; other site 1156913010864 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1156913010865 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913010866 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913010867 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913010868 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1156913010869 beta-galactosidase; Region: BGL; TIGR03356 1156913010870 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913010871 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1156913010872 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913010873 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1156913010874 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1156913010875 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1156913010876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913010877 FtsX-like permease family; Region: FtsX; pfam02687 1156913010878 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1156913010879 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 1156913010880 4Fe-4S binding domain; Region: Fer4; pfam00037 1156913010881 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1156913010882 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1156913010883 dimer interface [polypeptide binding]; other site 1156913010884 active site 1156913010885 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913010886 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913010887 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1156913010888 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913010889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913010890 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 1156913010891 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1156913010892 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1156913010893 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1156913010894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913010895 dimer interface [polypeptide binding]; other site 1156913010896 conserved gate region; other site 1156913010897 putative PBP binding loops; other site 1156913010898 ABC-ATPase subunit interface; other site 1156913010899 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1156913010900 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1156913010901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913010902 dimer interface [polypeptide binding]; other site 1156913010903 conserved gate region; other site 1156913010904 putative PBP binding loops; other site 1156913010905 ABC-ATPase subunit interface; other site 1156913010906 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1156913010907 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913010908 Walker A/P-loop; other site 1156913010909 ATP binding site [chemical binding]; other site 1156913010910 Q-loop/lid; other site 1156913010911 ABC transporter signature motif; other site 1156913010912 Walker B; other site 1156913010913 D-loop; other site 1156913010914 H-loop/switch region; other site 1156913010915 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913010916 Walker A/P-loop; other site 1156913010917 ATP binding site [chemical binding]; other site 1156913010918 Q-loop/lid; other site 1156913010919 ABC transporter signature motif; other site 1156913010920 Walker B; other site 1156913010921 D-loop; other site 1156913010922 H-loop/switch region; other site 1156913010923 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1156913010924 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1156913010925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1156913010926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913010927 S-adenosylmethionine binding site [chemical binding]; other site 1156913010928 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1156913010929 dimer interface [polypeptide binding]; other site 1156913010930 catalytic triad [active] 1156913010931 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1156913010932 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913010933 conserved hypothetical protein; Region: TIGR03847 1156913010934 conserved hypothetical protein; Region: TIGR03843 1156913010935 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1156913010936 Phosphotransferase enzyme family; Region: APH; pfam01636 1156913010937 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1156913010938 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1156913010939 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1156913010940 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1156913010941 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1156913010942 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1156913010943 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913010944 DNA binding residues [nucleotide binding] 1156913010945 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913010946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913010947 putative substrate translocation pore; other site 1156913010948 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1156913010949 Predicted flavoprotein [General function prediction only]; Region: COG0431 1156913010950 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913010951 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1156913010952 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913010953 dimerization interface [polypeptide binding]; other site 1156913010954 putative DNA binding site [nucleotide binding]; other site 1156913010955 putative Zn2+ binding site [ion binding]; other site 1156913010956 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1156913010957 putative hydrophobic ligand binding site [chemical binding]; other site 1156913010958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913010959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913010960 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1156913010961 active site 1156913010962 catalytic triad [active] 1156913010963 oxyanion hole [active] 1156913010964 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1156913010965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913010966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913010967 VanZ like family; Region: VanZ; pfam04892 1156913010968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913010969 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1156913010970 Histidine kinase; Region: HisKA_3; pfam07730 1156913010971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913010972 ATP binding site [chemical binding]; other site 1156913010973 Mg2+ binding site [ion binding]; other site 1156913010974 G-X-G motif; other site 1156913010975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913010976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913010977 active site 1156913010978 phosphorylation site [posttranslational modification] 1156913010979 intermolecular recognition site; other site 1156913010980 dimerization interface [polypeptide binding]; other site 1156913010981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913010982 DNA binding residues [nucleotide binding] 1156913010983 dimerization interface [polypeptide binding]; other site 1156913010984 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1156913010985 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913010986 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913010987 MarR family; Region: MarR; pfam01047 1156913010988 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1156913010989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913010990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913010991 dimerization interface [polypeptide binding]; other site 1156913010992 short chain dehydrogenase; Provisional; Region: PRK12744 1156913010993 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1156913010994 NADP binding site [chemical binding]; other site 1156913010995 homodimer interface [polypeptide binding]; other site 1156913010996 active site 1156913010997 substrate binding site [chemical binding]; other site 1156913010998 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1156913010999 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913011000 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1156913011001 nucleoside/Zn binding site; other site 1156913011002 dimer interface [polypeptide binding]; other site 1156913011003 catalytic motif [active] 1156913011004 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1156913011005 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913011006 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1156913011007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913011008 putative DNA binding site [nucleotide binding]; other site 1156913011009 putative Zn2+ binding site [ion binding]; other site 1156913011010 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913011011 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913011012 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1156913011013 hypothetical protein; Provisional; Region: PRK06834 1156913011014 TrkA-N domain; Region: TrkA_N; pfam02254 1156913011015 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913011016 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913011017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011018 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1156913011019 hypothetical protein; Provisional; Region: PRK07236 1156913011020 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913011021 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1156913011022 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913011023 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1156913011024 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1156913011025 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1156913011026 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1156913011027 catalytic site [active] 1156913011028 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1156913011029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913011030 S-adenosylmethionine binding site [chemical binding]; other site 1156913011031 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1156913011032 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913011033 putative NAD(P) binding site [chemical binding]; other site 1156913011034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011036 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1156913011037 active site 1156913011038 DNA binding site [nucleotide binding] 1156913011039 Int/Topo IB signature motif; other site 1156913011040 Plasmid conjugative transfer protein PilI; Region: PilI; pfam10623 1156913011041 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1156913011042 classical (c) SDRs; Region: SDR_c; cd05233 1156913011043 NAD(P) binding site [chemical binding]; other site 1156913011044 active site 1156913011045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913011046 salt bridge; other site 1156913011047 non-specific DNA binding site [nucleotide binding]; other site 1156913011048 sequence-specific DNA binding site [nucleotide binding]; other site 1156913011049 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913011050 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1156913011051 active site 1156913011052 catalytic triad [active] 1156913011053 oxyanion hole [active] 1156913011054 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1156913011055 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1156913011056 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1156913011057 calcium binding site 2 [ion binding]; other site 1156913011058 active site 1156913011059 catalytic triad [active] 1156913011060 calcium binding site 1 [ion binding]; other site 1156913011061 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1156913011062 Cytochrome P450; Region: p450; cl12078 1156913011063 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1156913011064 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1156913011065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913011066 NAD(P) binding site [chemical binding]; other site 1156913011067 active site 1156913011068 Predicted transcriptional regulator [Transcription]; Region: COG2378 1156913011069 HTH domain; Region: HTH_11; pfam08279 1156913011070 WYL domain; Region: WYL; pfam13280 1156913011071 Cupin; Region: Cupin_6; pfam12852 1156913011072 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913011073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913011074 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1156913011075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913011076 NAD(P) binding site [chemical binding]; other site 1156913011077 active site 1156913011078 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1156913011079 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913011080 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1156913011081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913011082 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913011083 homodimer interface [polypeptide binding]; other site 1156913011084 active site 1156913011085 TDP-binding site; other site 1156913011086 acceptor substrate-binding pocket; other site 1156913011087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011089 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913011090 SNF2 Helicase protein; Region: DUF3670; pfam12419 1156913011091 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1156913011092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913011093 ATP binding site [chemical binding]; other site 1156913011094 putative Mg++ binding site [ion binding]; other site 1156913011095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913011096 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1156913011097 nucleotide binding region [chemical binding]; other site 1156913011098 ATP-binding site [chemical binding]; other site 1156913011099 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1156913011100 SWIM zinc finger; Region: SWIM; pfam04434 1156913011101 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1156913011102 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913011103 active site 1156913011104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011106 AhpC/TSA family; Region: AhpC-TSA; pfam00578 1156913011107 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913011108 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913011109 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1156913011110 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913011111 DNA binding residues [nucleotide binding] 1156913011112 Walker B motif; other site 1156913011113 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1156913011114 DinB superfamily; Region: DinB_2; pfam12867 1156913011115 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 1156913011116 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1156913011117 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1156913011118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913011119 S-adenosylmethionine binding site [chemical binding]; other site 1156913011120 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1156913011121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913011122 S-adenosylmethionine binding site [chemical binding]; other site 1156913011123 hypothetical protein; Provisional; Region: PRK08317 1156913011124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913011125 S-adenosylmethionine binding site [chemical binding]; other site 1156913011126 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913011127 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1156913011128 dimer interface [polypeptide binding]; other site 1156913011129 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 1156913011130 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1156913011131 active site 1156913011132 DNA binding site [nucleotide binding] 1156913011133 Int/Topo IB signature motif; other site 1156913011134 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1156913011135 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1156913011136 putative active site [active] 1156913011137 catalytic site [active] 1156913011138 putative metal binding site [ion binding]; other site 1156913011139 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1156913011140 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913011141 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 1156913011142 thymidine kinase; Provisional; Region: PRK04296 1156913011143 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1156913011144 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1156913011145 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1156913011146 dimer interface [polypeptide binding]; other site 1156913011147 active site 1156913011148 catalytic residue [active] 1156913011149 classical (c) SDRs; Region: SDR_c; cd05233 1156913011150 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1156913011151 NAD(P) binding site [chemical binding]; other site 1156913011152 active site 1156913011153 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1156913011154 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913011155 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913011156 DNA binding residues [nucleotide binding] 1156913011157 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913011158 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1156913011159 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1156913011160 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1156913011161 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1156913011162 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1156913011163 Ligand binding site; other site 1156913011164 Putative Catalytic site; other site 1156913011165 DXD motif; other site 1156913011166 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1156913011167 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1156913011168 putative active site [active] 1156913011169 catalytic triad [active] 1156913011170 putative dimer interface [polypeptide binding]; other site 1156913011171 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1156913011172 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913011173 active site 1156913011174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1156913011175 benzoate transport; Region: 2A0115; TIGR00895 1156913011176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913011177 putative substrate translocation pore; other site 1156913011178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913011179 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1156913011180 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913011181 nucleotide binding site [chemical binding]; other site 1156913011182 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1156913011183 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913011184 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1156913011185 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913011186 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1156913011187 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1156913011188 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1156913011189 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 1156913011190 NAD binding site [chemical binding]; other site 1156913011191 catalytic Zn binding site [ion binding]; other site 1156913011192 substrate binding site [chemical binding]; other site 1156913011193 structural Zn binding site [ion binding]; other site 1156913011194 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1156913011195 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1156913011196 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1156913011197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913011198 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1156913011199 dimerization interface [polypeptide binding]; other site 1156913011200 substrate binding pocket [chemical binding]; other site 1156913011201 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1156913011202 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 1156913011203 active site 1156913011204 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 1156913011205 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1156913011206 active site 1156913011207 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 1156913011208 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1156913011209 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1156913011210 tetramer interface [polypeptide binding]; other site 1156913011211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913011212 catalytic residue [active] 1156913011213 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1156913011214 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1156913011215 dimer interface [polypeptide binding]; other site 1156913011216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913011217 catalytic residue [active] 1156913011218 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 1156913011219 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1156913011220 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1156913011221 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1156913011222 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1156913011223 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1156913011224 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 1156913011225 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913011226 sugar binding site [chemical binding]; other site 1156913011227 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913011228 Interdomain contacts; other site 1156913011229 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913011230 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913011231 active site 1156913011232 metal binding site [ion binding]; metal-binding site 1156913011233 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913011234 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 1156913011235 sugar binding site [chemical binding]; other site 1156913011236 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913011237 Interdomain contacts; other site 1156913011238 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913011239 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913011240 active site 1156913011241 metal binding site [ion binding]; metal-binding site 1156913011242 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1156913011243 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913011244 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1156913011245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913011246 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1156913011247 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1156913011248 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1156913011249 ornithine cyclodeaminase; Validated; Region: PRK08618 1156913011250 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1156913011251 CHAT domain; Region: CHAT; cl17868 1156913011252 Carboxylesterase family; Region: COesterase; pfam00135 1156913011253 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1156913011254 substrate binding pocket [chemical binding]; other site 1156913011255 catalytic triad [active] 1156913011256 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1156913011257 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1156913011258 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1156913011259 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1156913011260 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1156913011261 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1156913011262 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913011263 catalytic loop [active] 1156913011264 iron binding site [ion binding]; other site 1156913011265 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1156913011266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011270 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913011271 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1156913011272 NADP binding site [chemical binding]; other site 1156913011273 dimer interface [polypeptide binding]; other site 1156913011274 SnoaL-like domain; Region: SnoaL_4; pfam13577 1156913011275 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1156913011276 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913011277 pyruvate dehydrogenase; Provisional; Region: PRK06546 1156913011278 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1156913011279 PYR/PP interface [polypeptide binding]; other site 1156913011280 dimer interface [polypeptide binding]; other site 1156913011281 tetramer interface [polypeptide binding]; other site 1156913011282 TPP binding site [chemical binding]; other site 1156913011283 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1156913011284 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1156913011285 TPP-binding site [chemical binding]; other site 1156913011286 Isochorismatase family; Region: Isochorismatase; pfam00857 1156913011287 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1156913011288 catalytic triad [active] 1156913011289 conserved cis-peptide bond; other site 1156913011290 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1156913011291 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913011292 conserved cys residue [active] 1156913011293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913011294 dimerization interface [polypeptide binding]; other site 1156913011295 putative DNA binding site [nucleotide binding]; other site 1156913011296 putative Zn2+ binding site [ion binding]; other site 1156913011297 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1156913011298 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913011299 inhibitor-cofactor binding pocket; inhibition site 1156913011300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913011301 catalytic residue [active] 1156913011302 The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918 1156913011303 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913011304 acyl-activating enzyme (AAE) consensus motif; other site 1156913011305 AMP binding site [chemical binding]; other site 1156913011306 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913011307 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1156913011308 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1156913011309 putative CoA binding site [chemical binding]; other site 1156913011310 aspartate kinase; Reviewed; Region: PRK06635 1156913011311 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1156913011312 nucleotide binding site [chemical binding]; other site 1156913011313 substrate binding site [chemical binding]; other site 1156913011314 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1156913011315 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913011316 Ligand Binding Site [chemical binding]; other site 1156913011317 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913011318 Ligand Binding Site [chemical binding]; other site 1156913011319 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1156913011320 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913011321 Walker A/P-loop; other site 1156913011322 ATP binding site [chemical binding]; other site 1156913011323 Q-loop/lid; other site 1156913011324 ABC transporter signature motif; other site 1156913011325 Walker B; other site 1156913011326 D-loop; other site 1156913011327 H-loop/switch region; other site 1156913011328 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1156913011329 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1156913011330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1156913011331 Histidine kinase; Region: HisKA_3; pfam07730 1156913011332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913011333 ATP binding site [chemical binding]; other site 1156913011334 Mg2+ binding site [ion binding]; other site 1156913011335 G-X-G motif; other site 1156913011336 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913011337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913011338 active site 1156913011339 phosphorylation site [posttranslational modification] 1156913011340 intermolecular recognition site; other site 1156913011341 dimerization interface [polypeptide binding]; other site 1156913011342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913011343 DNA binding residues [nucleotide binding] 1156913011344 dimerization interface [polypeptide binding]; other site 1156913011345 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1156913011346 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1156913011347 intersubunit interface [polypeptide binding]; other site 1156913011348 PQQ-like domain; Region: PQQ_2; pfam13360 1156913011349 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1156913011350 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913011351 ABC-ATPase subunit interface; other site 1156913011352 dimer interface [polypeptide binding]; other site 1156913011353 putative PBP binding regions; other site 1156913011354 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1156913011355 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1156913011356 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1156913011357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011359 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1156913011360 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913011361 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1156913011362 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913011363 NAD binding site [chemical binding]; other site 1156913011364 catalytic residues [active] 1156913011365 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1156913011366 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1156913011367 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1156913011368 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1156913011369 nucleotide binding pocket [chemical binding]; other site 1156913011370 K-X-D-G motif; other site 1156913011371 catalytic site [active] 1156913011372 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1156913011373 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1156913011374 Dimer interface [polypeptide binding]; other site 1156913011375 BRCT sequence motif; other site 1156913011376 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1156913011377 substrate binding pocket [chemical binding]; other site 1156913011378 substrate-Mg2+ binding site; other site 1156913011379 aspartate-rich region 1; other site 1156913011380 aspartate-rich region 2; other site 1156913011381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913011382 S-adenosylmethionine binding site [chemical binding]; other site 1156913011383 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1156913011384 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1156913011385 ligand binding site [chemical binding]; other site 1156913011386 flexible hinge region; other site 1156913011387 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1156913011388 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1156913011389 ligand binding site [chemical binding]; other site 1156913011390 flexible hinge region; other site 1156913011391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913011392 dimerization interface [polypeptide binding]; other site 1156913011393 putative DNA binding site [nucleotide binding]; other site 1156913011394 putative Zn2+ binding site [ion binding]; other site 1156913011395 Cation efflux family; Region: Cation_efflux; cl00316 1156913011396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913011397 S-adenosylmethionine binding site [chemical binding]; other site 1156913011398 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 1156913011399 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1156913011400 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011401 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011402 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913011403 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1156913011404 putative NAD(P) binding site [chemical binding]; other site 1156913011405 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1156913011406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011408 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1156913011409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913011410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913011411 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1156913011412 putative dimerization interface [polypeptide binding]; other site 1156913011413 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1156913011414 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1156913011415 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1156913011416 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1156913011417 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913011418 DNA binding site [nucleotide binding] 1156913011419 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913011420 Predicted ATPase [General function prediction only]; Region: COG3903 1156913011421 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913011422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913011423 Walker A/P-loop; other site 1156913011424 ATP binding site [chemical binding]; other site 1156913011425 Q-loop/lid; other site 1156913011426 ABC transporter signature motif; other site 1156913011427 Walker B; other site 1156913011428 D-loop; other site 1156913011429 H-loop/switch region; other site 1156913011430 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913011431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913011432 Walker A/P-loop; other site 1156913011433 ATP binding site [chemical binding]; other site 1156913011434 Q-loop/lid; other site 1156913011435 ABC transporter signature motif; other site 1156913011436 Walker B; other site 1156913011437 D-loop; other site 1156913011438 H-loop/switch region; other site 1156913011439 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1156913011440 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913011441 sugar binding site [chemical binding]; other site 1156913011442 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1156913011443 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1156913011444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913011445 putative substrate translocation pore; other site 1156913011446 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1156913011447 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 1156913011448 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1156913011449 Zn binding site [ion binding]; other site 1156913011450 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1156913011451 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913011452 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1156913011453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913011454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913011455 DNA binding residues [nucleotide binding] 1156913011456 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913011457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913011458 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1156913011459 NAD(P) binding site [chemical binding]; other site 1156913011460 active site 1156913011461 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1156913011462 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1156913011463 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1156913011464 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 1156913011465 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 1156913011466 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913011467 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913011468 dimerization interface [polypeptide binding]; other site 1156913011469 putative Zn2+ binding site [ion binding]; other site 1156913011470 putative DNA binding site [nucleotide binding]; other site 1156913011471 malate dehydrogenase; Provisional; Region: PRK05442 1156913011472 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1156913011473 NAD(P) binding site [chemical binding]; other site 1156913011474 dimer interface [polypeptide binding]; other site 1156913011475 malate binding site [chemical binding]; other site 1156913011476 SWIM zinc finger; Region: SWIM; pfam04434 1156913011477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011479 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913011480 Right handed beta helix region; Region: Beta_helix; pfam13229 1156913011481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913011482 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1156913011483 DNA-binding site [nucleotide binding]; DNA binding site 1156913011484 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913011485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913011486 homodimer interface [polypeptide binding]; other site 1156913011487 catalytic residue [active] 1156913011488 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913011489 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1156913011490 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913011491 catalytic residue [active] 1156913011492 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1156913011493 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1156913011494 active site 1156913011495 Zn binding site [ion binding]; other site 1156913011496 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913011497 catalytic core [active] 1156913011498 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1156913011499 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1156913011500 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913011501 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913011502 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913011503 active site 1156913011504 catalytic tetrad [active] 1156913011505 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1156913011506 putative hydrophobic ligand binding site [chemical binding]; other site 1156913011507 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913011508 putative DNA binding site [nucleotide binding]; other site 1156913011509 putative Zn2+ binding site [ion binding]; other site 1156913011510 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913011511 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913011512 hypothetical protein; Provisional; Region: PRK07906 1156913011513 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1156913011514 putative metal binding site [ion binding]; other site 1156913011515 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1156913011516 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913011517 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913011518 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 1156913011519 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913011520 Peptidase family M23; Region: Peptidase_M23; pfam01551 1156913011521 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1156913011522 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1156913011523 active site 1156913011524 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1156913011525 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913011526 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913011527 FG-GAP repeat; Region: FG-GAP; pfam01839 1156913011528 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1156913011529 PhoD-like phosphatase; Region: PhoD; pfam09423 1156913011530 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1156913011531 putative active site [active] 1156913011532 putative metal binding site [ion binding]; other site 1156913011533 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913011534 putative DNA binding site [nucleotide binding]; other site 1156913011535 putative Zn2+ binding site [ion binding]; other site 1156913011536 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1156913011537 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913011538 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 1156913011539 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1156913011540 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913011541 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913011542 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913011543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913011544 active site 1156913011545 phosphorylation site [posttranslational modification] 1156913011546 intermolecular recognition site; other site 1156913011547 dimerization interface [polypeptide binding]; other site 1156913011548 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913011549 DNA binding residues [nucleotide binding] 1156913011550 dimerization interface [polypeptide binding]; other site 1156913011551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913011552 Histidine kinase; Region: HisKA_3; pfam07730 1156913011553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913011554 ATP binding site [chemical binding]; other site 1156913011555 Mg2+ binding site [ion binding]; other site 1156913011556 G-X-G motif; other site 1156913011557 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1156913011558 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1156913011559 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1156913011560 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 1156913011561 active site 1156913011562 zinc binding site [ion binding]; other site 1156913011563 Predicted ATPase [General function prediction only]; Region: COG3899 1156913011564 AAA ATPase domain; Region: AAA_16; pfam13191 1156913011565 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913011566 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913011567 DNA binding residues [nucleotide binding] 1156913011568 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1156913011569 catalytic residues [active] 1156913011570 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1156913011571 dimanganese center [ion binding]; other site 1156913011572 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1156913011573 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1156913011574 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1156913011575 NAD(P) binding site [chemical binding]; other site 1156913011576 catalytic residues [active] 1156913011577 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1156913011578 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1156913011579 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 1156913011580 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1156913011581 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1156913011582 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1156913011583 homodimer interface [polypeptide binding]; other site 1156913011584 NADP binding site [chemical binding]; other site 1156913011585 substrate binding site [chemical binding]; other site 1156913011586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011588 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913011589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913011590 S-adenosylmethionine binding site [chemical binding]; other site 1156913011591 Cellulose binding domain; Region: CBM_2; pfam00553 1156913011592 Right handed beta helix region; Region: Beta_helix; pfam13229 1156913011593 Cellulose binding domain; Region: CBM_2; pfam00553 1156913011594 Predicted flavoprotein [General function prediction only]; Region: COG0431 1156913011595 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1156913011596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913011597 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913011598 putative substrate translocation pore; other site 1156913011599 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913011600 dimerization interface [polypeptide binding]; other site 1156913011601 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913011602 putative DNA binding site [nucleotide binding]; other site 1156913011603 putative Zn2+ binding site [ion binding]; other site 1156913011604 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1156913011605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913011606 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1156913011607 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1156913011608 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1156913011609 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1156913011610 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1156913011611 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1156913011612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913011613 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913011614 putative substrate translocation pore; other site 1156913011615 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1156913011616 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1156913011617 amphi-Trp domain; Region: amphi-Trp; TIGR04354 1156913011618 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 1156913011619 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 1156913011620 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1156913011621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913011622 short chain dehydrogenase; Provisional; Region: PRK12937 1156913011623 NAD(P) binding site [chemical binding]; other site 1156913011624 active site 1156913011625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011627 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1156913011628 Helix-turn-helix domain; Region: HTH_18; pfam12833 1156913011629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913011630 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913011631 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1156913011632 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1156913011633 xylose isomerase; Provisional; Region: PRK12677 1156913011634 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 1156913011635 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913011636 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913011637 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913011638 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913011639 putative DNA binding site [nucleotide binding]; other site 1156913011640 putative Zn2+ binding site [ion binding]; other site 1156913011641 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913011642 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1156913011643 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1156913011644 tetramer interface [polypeptide binding]; other site 1156913011645 TPP-binding site [chemical binding]; other site 1156913011646 heterodimer interface [polypeptide binding]; other site 1156913011647 phosphorylation loop region [posttranslational modification] 1156913011648 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1156913011649 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1156913011650 alpha subunit interface [polypeptide binding]; other site 1156913011651 TPP binding site [chemical binding]; other site 1156913011652 heterodimer interface [polypeptide binding]; other site 1156913011653 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1156913011654 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1156913011655 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1156913011656 E3 interaction surface; other site 1156913011657 lipoyl attachment site [posttranslational modification]; other site 1156913011658 e3 binding domain; Region: E3_binding; pfam02817 1156913011659 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1156913011660 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913011661 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1156913011662 active site 1156913011663 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913011664 PE-PPE domain; Region: PE-PPE; pfam08237 1156913011665 elongation factor G; Reviewed; Region: PRK13351 1156913011666 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1156913011667 G1 box; other site 1156913011668 putative GEF interaction site [polypeptide binding]; other site 1156913011669 GTP/Mg2+ binding site [chemical binding]; other site 1156913011670 Switch I region; other site 1156913011671 G2 box; other site 1156913011672 G3 box; other site 1156913011673 Switch II region; other site 1156913011674 G4 box; other site 1156913011675 G5 box; other site 1156913011676 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1156913011677 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1156913011678 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1156913011679 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1156913011680 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913011681 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913011682 DNA binding residues [nucleotide binding] 1156913011683 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913011684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913011685 putative substrate translocation pore; other site 1156913011686 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913011687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913011688 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1156913011689 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1156913011690 tetramer interface [polypeptide binding]; other site 1156913011691 active site 1156913011692 Mg2+/Mn2+ binding site [ion binding]; other site 1156913011693 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913011694 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913011695 Predicted transcriptional regulators [Transcription]; Region: COG1725 1156913011696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913011697 DNA-binding site [nucleotide binding]; DNA binding site 1156913011698 Predicted membrane protein [General function prediction only]; Region: COG4194 1156913011699 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1156913011700 dimerization interface [polypeptide binding]; other site 1156913011701 substrate binding pocket [chemical binding]; other site 1156913011702 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1156913011703 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1156913011704 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1156913011705 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1156913011706 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1156913011707 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913011708 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913011709 TM-ABC transporter signature motif; other site 1156913011710 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913011711 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913011712 TM-ABC transporter signature motif; other site 1156913011713 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1156913011714 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1156913011715 Walker A/P-loop; other site 1156913011716 ATP binding site [chemical binding]; other site 1156913011717 ABC transporter signature motif; other site 1156913011718 Walker B; other site 1156913011719 D-loop; other site 1156913011720 H-loop/switch region; other site 1156913011721 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1156913011722 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1156913011723 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1156913011724 putative ligand binding site [chemical binding]; other site 1156913011725 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913011726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913011727 DNA binding site [nucleotide binding] 1156913011728 domain linker motif; other site 1156913011729 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1156913011730 ligand binding site [chemical binding]; other site 1156913011731 dimerization interface [polypeptide binding]; other site 1156913011732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913011733 Histidine kinase; Region: HisKA_3; pfam07730 1156913011734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913011735 ATP binding site [chemical binding]; other site 1156913011736 Mg2+ binding site [ion binding]; other site 1156913011737 G-X-G motif; other site 1156913011738 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913011739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913011740 active site 1156913011741 phosphorylation site [posttranslational modification] 1156913011742 intermolecular recognition site; other site 1156913011743 dimerization interface [polypeptide binding]; other site 1156913011744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913011745 DNA binding residues [nucleotide binding] 1156913011746 dimerization interface [polypeptide binding]; other site 1156913011747 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1156913011748 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1156913011749 conserved cys residue [active] 1156913011750 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1156913011751 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1156913011752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1156913011753 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1156913011754 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1156913011755 FtsX-like permease family; Region: FtsX; pfam02687 1156913011756 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1156913011757 FtsX-like permease family; Region: FtsX; pfam02687 1156913011758 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913011759 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1156913011760 Walker A/P-loop; other site 1156913011761 ATP binding site [chemical binding]; other site 1156913011762 Q-loop/lid; other site 1156913011763 ABC transporter signature motif; other site 1156913011764 Walker B; other site 1156913011765 D-loop; other site 1156913011766 H-loop/switch region; other site 1156913011767 amidase; Provisional; Region: PRK07486 1156913011768 Amidase; Region: Amidase; pfam01425 1156913011769 metabolite-proton symporter; Region: 2A0106; TIGR00883 1156913011770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913011771 putative substrate translocation pore; other site 1156913011772 SnoaL-like domain; Region: SnoaL_4; pfam13577 1156913011773 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1156913011774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913011775 active site 1156913011776 phosphorylation site [posttranslational modification] 1156913011777 intermolecular recognition site; other site 1156913011778 dimerization interface [polypeptide binding]; other site 1156913011779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913011780 DNA binding residues [nucleotide binding] 1156913011781 dimerization interface [polypeptide binding]; other site 1156913011782 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1156913011783 Amidase; Region: Amidase; cl11426 1156913011784 Flavin Reductases; Region: FlaRed; cl00801 1156913011785 PAS domain; Region: PAS_9; pfam13426 1156913011786 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1156913011787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913011788 ATP binding site [chemical binding]; other site 1156913011789 Mg2+ binding site [ion binding]; other site 1156913011790 G-X-G motif; other site 1156913011791 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913011792 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913011793 active site 1156913011794 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 1156913011795 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1156913011796 [2Fe-2S] cluster binding site [ion binding]; other site 1156913011797 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1156913011798 putative alpha subunit interface [polypeptide binding]; other site 1156913011799 putative active site [active] 1156913011800 putative substrate binding site [chemical binding]; other site 1156913011801 Fe binding site [ion binding]; other site 1156913011802 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1156913011803 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1156913011804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913011805 NAD(P) binding site [chemical binding]; other site 1156913011806 active site 1156913011807 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1156913011808 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1156913011809 FMN-binding pocket [chemical binding]; other site 1156913011810 flavin binding motif; other site 1156913011811 phosphate binding motif [ion binding]; other site 1156913011812 beta-alpha-beta structure motif; other site 1156913011813 NAD binding pocket [chemical binding]; other site 1156913011814 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913011815 catalytic loop [active] 1156913011816 iron binding site [ion binding]; other site 1156913011817 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913011818 Cytochrome P450; Region: p450; cl12078 1156913011819 Ferredoxin [Energy production and conversion]; Region: COG1146 1156913011820 4Fe-4S binding domain; Region: Fer4; pfam00037 1156913011821 ferredoxin-NADP+ reductase; Region: PLN02852 1156913011822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913011823 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1156913011824 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913011825 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1156913011826 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1156913011827 Putative sensor; Region: Sensor; pfam13796 1156913011828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913011829 Histidine kinase; Region: HisKA_3; pfam07730 1156913011830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913011831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913011832 active site 1156913011833 phosphorylation site [posttranslational modification] 1156913011834 intermolecular recognition site; other site 1156913011835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913011836 DNA binding residues [nucleotide binding] 1156913011837 dimerization interface [polypeptide binding]; other site 1156913011838 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1156913011839 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1156913011840 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1156913011841 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913011842 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913011843 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913011844 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1156913011845 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913011846 Walker A/P-loop; other site 1156913011847 ATP binding site [chemical binding]; other site 1156913011848 Q-loop/lid; other site 1156913011849 ABC transporter signature motif; other site 1156913011850 Walker B; other site 1156913011851 D-loop; other site 1156913011852 H-loop/switch region; other site 1156913011853 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1156913011854 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1156913011855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913011856 dimer interface [polypeptide binding]; other site 1156913011857 conserved gate region; other site 1156913011858 ABC-ATPase subunit interface; other site 1156913011859 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1156913011860 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913011861 Walker A/P-loop; other site 1156913011862 ATP binding site [chemical binding]; other site 1156913011863 Q-loop/lid; other site 1156913011864 ABC transporter signature motif; other site 1156913011865 Walker B; other site 1156913011866 D-loop; other site 1156913011867 H-loop/switch region; other site 1156913011868 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1156913011869 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1156913011870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913011871 dimer interface [polypeptide binding]; other site 1156913011872 conserved gate region; other site 1156913011873 ABC-ATPase subunit interface; other site 1156913011874 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1156913011875 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1156913011876 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1156913011877 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913011878 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913011879 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1156913011880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913011881 D-galactonate transporter; Region: 2A0114; TIGR00893 1156913011882 putative substrate translocation pore; other site 1156913011883 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913011884 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1156913011885 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1156913011886 active site 1156913011887 octamer interface [polypeptide binding]; other site 1156913011888 Uncharacterized conserved protein [Function unknown]; Region: COG3375 1156913011889 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1156913011890 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1156913011891 metal binding site [ion binding]; metal-binding site 1156913011892 dimer interface [polypeptide binding]; other site 1156913011893 D-glutamate deacylase; Validated; Region: PRK09061 1156913011894 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913011895 active site 1156913011896 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913011897 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1156913011898 beta-galactosidase; Region: BGL; TIGR03356 1156913011899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1156913011900 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913011901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913011902 dimer interface [polypeptide binding]; other site 1156913011903 conserved gate region; other site 1156913011904 putative PBP binding loops; other site 1156913011905 ABC-ATPase subunit interface; other site 1156913011906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913011907 dimer interface [polypeptide binding]; other site 1156913011908 conserved gate region; other site 1156913011909 putative PBP binding loops; other site 1156913011910 ABC-ATPase subunit interface; other site 1156913011911 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913011912 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913011913 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1156913011914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913011915 DNA-binding site [nucleotide binding]; DNA binding site 1156913011916 FCD domain; Region: FCD; pfam07729 1156913011917 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1156913011918 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913011919 putative metal binding site [ion binding]; other site 1156913011920 Cupin domain; Region: Cupin_2; pfam07883 1156913011921 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1156913011922 homotrimer interaction site [polypeptide binding]; other site 1156913011923 putative active site [active] 1156913011924 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913011925 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913011926 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913011927 MarR family; Region: MarR_2; pfam12802 1156913011928 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913011929 TIGR03086 family protein; Region: TIGR03086 1156913011930 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913011931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913011932 putative substrate translocation pore; other site 1156913011933 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1156913011934 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913011935 dimerization interface [polypeptide binding]; other site 1156913011936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913011937 dimer interface [polypeptide binding]; other site 1156913011938 phosphorylation site [posttranslational modification] 1156913011939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913011940 ATP binding site [chemical binding]; other site 1156913011941 Mg2+ binding site [ion binding]; other site 1156913011942 G-X-G motif; other site 1156913011943 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913011944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913011945 active site 1156913011946 phosphorylation site [posttranslational modification] 1156913011947 intermolecular recognition site; other site 1156913011948 dimerization interface [polypeptide binding]; other site 1156913011949 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913011950 DNA binding site [nucleotide binding] 1156913011951 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1156913011952 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 1156913011953 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1156913011954 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1156913011955 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913011956 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913011957 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913011958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913011959 ABC-ATPase subunit interface; other site 1156913011960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1156913011961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913011962 dimer interface [polypeptide binding]; other site 1156913011963 ABC-ATPase subunit interface; other site 1156913011964 putative PBP binding loops; other site 1156913011965 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913011966 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913011967 DNA binding site [nucleotide binding] 1156913011968 domain linker motif; other site 1156913011969 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1156913011970 ligand binding site [chemical binding]; other site 1156913011971 dimerization interface (open form) [polypeptide binding]; other site 1156913011972 dimerization interface (closed form) [polypeptide binding]; other site 1156913011973 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1156913011974 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1156913011975 putative NAD(P) binding site [chemical binding]; other site 1156913011976 putative active site [active] 1156913011977 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1156913011978 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913011979 MMPL family; Region: MMPL; pfam03176 1156913011980 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913011981 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913011982 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913011983 putative DNA binding site [nucleotide binding]; other site 1156913011984 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1156913011985 AAA domain; Region: AAA_18; pfam13238 1156913011986 AAA domain; Region: AAA_17; pfam13207 1156913011987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913011988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913011989 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1156913011990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913011991 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1156913011992 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1156913011993 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1156913011994 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1156913011995 Di-iron ligands [ion binding]; other site 1156913011996 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1156913011997 Rubredoxin; Region: Rubredoxin; pfam00301 1156913011998 iron binding site [ion binding]; other site 1156913011999 SdiA-regulated; Region: SdiA-regulated; cd09971 1156913012000 putative active site [active] 1156913012001 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 1156913012002 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1156913012003 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1156913012004 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913012005 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1156913012006 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1156913012007 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1156913012008 dimer interface [polypeptide binding]; other site 1156913012009 active site 1156913012010 heme binding site [chemical binding]; other site 1156913012011 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1156913012012 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1156913012013 metal binding site 2 [ion binding]; metal-binding site 1156913012014 putative DNA binding helix; other site 1156913012015 metal binding site 1 [ion binding]; metal-binding site 1156913012016 dimer interface [polypeptide binding]; other site 1156913012017 structural Zn2+ binding site [ion binding]; other site 1156913012018 cytidylate kinase; Provisional; Region: cmk; PRK00023 1156913012019 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1156913012020 CMP-binding site; other site 1156913012021 The sites determining sugar specificity; other site 1156913012022 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1156913012023 nucleotide binding site/active site [active] 1156913012024 HIT family signature motif; other site 1156913012025 catalytic residue [active] 1156913012026 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913012027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913012028 S-adenosylmethionine binding site [chemical binding]; other site 1156913012029 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1156913012030 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1156913012031 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1156913012032 ATP binding site [chemical binding]; other site 1156913012033 dimerization interface [polypeptide binding]; other site 1156913012034 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 1156913012035 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1156913012036 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1156913012037 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913012038 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1156913012039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913012040 metabolite-proton symporter; Region: 2A0106; TIGR00883 1156913012041 putative substrate translocation pore; other site 1156913012042 hypothetical protein; Provisional; Region: PRK12764 1156913012043 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1156913012044 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1156913012045 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1156913012046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1156913012047 DNA-binding site [nucleotide binding]; DNA binding site 1156913012048 FCD domain; Region: FCD; pfam07729 1156913012049 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1156913012050 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1156913012051 NAD binding site [chemical binding]; other site 1156913012052 catalytic residues [active] 1156913012053 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1156913012054 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 1156913012055 tetramer interface [polypeptide binding]; other site 1156913012056 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 1156913012057 tetramer interface [polypeptide binding]; other site 1156913012058 active site 1156913012059 metal binding site [ion binding]; metal-binding site 1156913012060 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1156913012061 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1156913012062 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913012063 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913012064 active site 1156913012065 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1156913012066 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1156913012067 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1156913012068 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1156913012069 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1156913012070 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1156913012071 active site 1156913012072 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1156913012073 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 1156913012074 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1156913012075 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913012076 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913012077 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913012078 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913012079 TM-ABC transporter signature motif; other site 1156913012080 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1156913012081 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1156913012082 Walker A/P-loop; other site 1156913012083 ATP binding site [chemical binding]; other site 1156913012084 Q-loop/lid; other site 1156913012085 ABC transporter signature motif; other site 1156913012086 Walker B; other site 1156913012087 D-loop; other site 1156913012088 H-loop/switch region; other site 1156913012089 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1156913012090 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1156913012091 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1156913012092 putative ligand binding site [chemical binding]; other site 1156913012093 L-arabinose isomerase; Provisional; Region: PRK02929 1156913012094 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1156913012095 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1156913012096 trimer interface [polypeptide binding]; other site 1156913012097 putative substrate binding site [chemical binding]; other site 1156913012098 putative metal binding site [ion binding]; other site 1156913012099 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1156913012100 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1156913012101 intersubunit interface [polypeptide binding]; other site 1156913012102 active site 1156913012103 Zn2+ binding site [ion binding]; other site 1156913012104 ribulokinase; Provisional; Region: PRK04123 1156913012105 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1156913012106 N- and C-terminal domain interface [polypeptide binding]; other site 1156913012107 active site 1156913012108 MgATP binding site [chemical binding]; other site 1156913012109 catalytic site [active] 1156913012110 metal binding site [ion binding]; metal-binding site 1156913012111 carbohydrate binding site [chemical binding]; other site 1156913012112 homodimer interface [polypeptide binding]; other site 1156913012113 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913012114 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913012115 TM-ABC transporter signature motif; other site 1156913012116 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913012117 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913012118 TM-ABC transporter signature motif; other site 1156913012119 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1156913012120 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1156913012121 Walker A/P-loop; other site 1156913012122 ATP binding site [chemical binding]; other site 1156913012123 Q-loop/lid; other site 1156913012124 ABC transporter signature motif; other site 1156913012125 Walker B; other site 1156913012126 D-loop; other site 1156913012127 H-loop/switch region; other site 1156913012128 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1156913012129 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1156913012130 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1156913012131 putative ligand binding site [chemical binding]; other site 1156913012132 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913012133 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913012134 DNA binding site [nucleotide binding] 1156913012135 domain linker motif; other site 1156913012136 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1156913012137 ligand binding site [chemical binding]; other site 1156913012138 dimerization interface (open form) [polypeptide binding]; other site 1156913012139 dimerization interface (closed form) [polypeptide binding]; other site 1156913012140 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913012141 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913012142 DNA binding site [nucleotide binding] 1156913012143 domain linker motif; other site 1156913012144 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1156913012145 putative dimerization interface [polypeptide binding]; other site 1156913012146 putative ligand binding site [chemical binding]; other site 1156913012147 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913012148 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1156913012149 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1156913012150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913012151 ABC-ATPase subunit interface; other site 1156913012152 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913012153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913012154 dimer interface [polypeptide binding]; other site 1156913012155 conserved gate region; other site 1156913012156 putative PBP binding loops; other site 1156913012157 ABC-ATPase subunit interface; other site 1156913012158 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1156913012159 beta-galactosidase; Region: BGL; TIGR03356 1156913012160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913012161 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1156913012162 Walker A/P-loop; other site 1156913012163 ATP binding site [chemical binding]; other site 1156913012164 Q-loop/lid; other site 1156913012165 ABC transporter signature motif; other site 1156913012166 Walker B; other site 1156913012167 D-loop; other site 1156913012168 H-loop/switch region; other site 1156913012169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913012170 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913012171 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913012172 active site 1156913012173 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1156913012174 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913012175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913012176 S-adenosylmethionine binding site [chemical binding]; other site 1156913012177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913012178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913012179 Cytochrome P450; Region: p450; pfam00067 1156913012180 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913012181 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1156913012182 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1156913012183 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1156913012184 Predicted transcriptional regulator [Transcription]; Region: COG2345 1156913012185 putative DNA binding site [nucleotide binding]; other site 1156913012186 putative Zn2+ binding site [ion binding]; other site 1156913012187 GTP cyclohydrolase I; Provisional; Region: PLN03044 1156913012188 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1156913012189 active site 1156913012190 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913012191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913012192 putative substrate translocation pore; other site 1156913012193 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1156913012194 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1156913012195 hydrophobic ligand binding site; other site 1156913012196 acyl-CoA synthetase; Validated; Region: PRK07788 1156913012197 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913012198 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1156913012199 putative AMP binding site [chemical binding]; other site 1156913012200 putative active site [active] 1156913012201 acyl-activating enzyme (AAE) consensus motif; other site 1156913012202 putative CoA binding site [chemical binding]; other site 1156913012203 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1156913012204 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913012205 acyl-activating enzyme (AAE) consensus motif; other site 1156913012206 AMP binding site [chemical binding]; other site 1156913012207 active site 1156913012208 CoA binding site [chemical binding]; other site 1156913012209 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913012210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913012211 DNA binding residues [nucleotide binding] 1156913012212 dimerization interface [polypeptide binding]; other site 1156913012213 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1156913012214 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913012215 conserved cys residue [active] 1156913012216 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913012217 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913012218 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1156913012219 FMN binding site [chemical binding]; other site 1156913012220 dimer interface [polypeptide binding]; other site 1156913012221 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 1156913012222 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1156913012223 GAF domain; Region: GAF; pfam01590 1156913012224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913012225 Histidine kinase; Region: HisKA_3; pfam07730 1156913012226 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1156913012227 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1156913012228 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913012229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913012230 active site 1156913012231 phosphorylation site [posttranslational modification] 1156913012232 intermolecular recognition site; other site 1156913012233 dimerization interface [polypeptide binding]; other site 1156913012234 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913012235 DNA binding residues [nucleotide binding] 1156913012236 dimerization interface [polypeptide binding]; other site 1156913012237 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1156913012238 Response regulator receiver domain; Region: Response_reg; pfam00072 1156913012239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913012240 active site 1156913012241 phosphorylation site [posttranslational modification] 1156913012242 intermolecular recognition site; other site 1156913012243 dimerization interface [polypeptide binding]; other site 1156913012244 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1156913012245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913012246 dimerization interface [polypeptide binding]; other site 1156913012247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913012248 dimerization interface [polypeptide binding]; other site 1156913012249 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1156913012250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913012251 dimerization interface [polypeptide binding]; other site 1156913012252 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913012253 dimerization interface [polypeptide binding]; other site 1156913012254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913012255 dimerization interface [polypeptide binding]; other site 1156913012256 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1156913012257 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913012258 dimerization interface [polypeptide binding]; other site 1156913012259 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913012260 dimerization interface [polypeptide binding]; other site 1156913012261 GAF domain; Region: GAF_2; pfam13185 1156913012262 GAF domain; Region: GAF; pfam01590 1156913012263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913012264 dimer interface [polypeptide binding]; other site 1156913012265 phosphorylation site [posttranslational modification] 1156913012266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913012267 ATP binding site [chemical binding]; other site 1156913012268 Mg2+ binding site [ion binding]; other site 1156913012269 G-X-G motif; other site 1156913012270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1156913012271 active site 1156913012272 phosphorylation site [posttranslational modification] 1156913012273 intermolecular recognition site; other site 1156913012274 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1156913012275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913012276 active site 1156913012277 phosphorylation site [posttranslational modification] 1156913012278 intermolecular recognition site; other site 1156913012279 dimerization interface [polypeptide binding]; other site 1156913012280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1156913012281 PAS domain; Region: PAS_9; pfam13426 1156913012282 putative active site [active] 1156913012283 heme pocket [chemical binding]; other site 1156913012284 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913012285 Histidine kinase; Region: HisKA_3; pfam07730 1156913012286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913012287 ATP binding site [chemical binding]; other site 1156913012288 Mg2+ binding site [ion binding]; other site 1156913012289 G-X-G motif; other site 1156913012290 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913012291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913012292 active site 1156913012293 phosphorylation site [posttranslational modification] 1156913012294 intermolecular recognition site; other site 1156913012295 dimerization interface [polypeptide binding]; other site 1156913012296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913012297 dimerization interface [polypeptide binding]; other site 1156913012298 DNA binding residues [nucleotide binding] 1156913012299 GAF domain; Region: GAF; cl17456 1156913012300 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1156913012301 spermidine synthase; Provisional; Region: PRK00811 1156913012302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913012303 S-adenosylmethionine binding site [chemical binding]; other site 1156913012304 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 1156913012305 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1156913012306 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1156913012307 dimer interface [polypeptide binding]; other site 1156913012308 active site 1156913012309 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1156913012310 catalytic residues [active] 1156913012311 substrate binding site [chemical binding]; other site 1156913012312 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913012313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913012314 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1156913012315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913012316 dimerization interface [polypeptide binding]; other site 1156913012317 putative Zn2+ binding site [ion binding]; other site 1156913012318 putative DNA binding site [nucleotide binding]; other site 1156913012319 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913012320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913012321 Walker A/P-loop; other site 1156913012322 ATP binding site [chemical binding]; other site 1156913012323 Q-loop/lid; other site 1156913012324 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1156913012325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913012326 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1156913012327 Walker A/P-loop; other site 1156913012328 ATP binding site [chemical binding]; other site 1156913012329 Q-loop/lid; other site 1156913012330 ABC transporter signature motif; other site 1156913012331 Walker B; other site 1156913012332 D-loop; other site 1156913012333 H-loop/switch region; other site 1156913012334 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1156913012335 nucleotide binding site [chemical binding]; other site 1156913012336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913012337 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1156913012338 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1156913012339 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1156913012340 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1156913012341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913012342 DNA-binding site [nucleotide binding]; DNA binding site 1156913012343 FCD domain; Region: FCD; pfam07729 1156913012344 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1156913012345 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1156913012346 putative active site [active] 1156913012347 catalytic triad [active] 1156913012348 putative dimer interface [polypeptide binding]; other site 1156913012349 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913012350 Penicillin amidase; Region: Penicil_amidase; pfam01804 1156913012351 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1156913012352 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1156913012353 active site 1156913012354 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1156913012355 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913012356 dimerization interface [polypeptide binding]; other site 1156913012357 putative DNA binding site [nucleotide binding]; other site 1156913012358 putative Zn2+ binding site [ion binding]; other site 1156913012359 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1156913012360 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1156913012361 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1156913012362 catalytic residue [active] 1156913012363 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1156913012364 glyoxylate carboligase; Provisional; Region: PRK11269 1156913012365 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1156913012366 PYR/PP interface [polypeptide binding]; other site 1156913012367 dimer interface [polypeptide binding]; other site 1156913012368 TPP binding site [chemical binding]; other site 1156913012369 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1156913012370 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1156913012371 TPP-binding site [chemical binding]; other site 1156913012372 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1156913012373 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1156913012374 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1156913012375 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1156913012376 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913012377 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1156913012378 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913012379 DNA binding residues [nucleotide binding] 1156913012380 drug binding residues [chemical binding]; other site 1156913012381 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1156913012382 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913012383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913012384 Coenzyme A binding pocket [chemical binding]; other site 1156913012385 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1156913012386 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1156913012387 substrate binding site [chemical binding]; other site 1156913012388 THF binding site; other site 1156913012389 zinc-binding site [ion binding]; other site 1156913012390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1156913012391 DNA polymerase IV; Validated; Region: PRK03352 1156913012392 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1156913012393 active site 1156913012394 DNA binding site [nucleotide binding] 1156913012395 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1156913012396 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1156913012397 homotetramer interface [polypeptide binding]; other site 1156913012398 ligand binding site [chemical binding]; other site 1156913012399 catalytic site [active] 1156913012400 NAD binding site [chemical binding]; other site 1156913012401 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1156913012402 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1156913012403 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1156913012404 putative DNA binding site [nucleotide binding]; other site 1156913012405 putative homodimer interface [polypeptide binding]; other site 1156913012406 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1156913012407 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1156913012408 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1156913012409 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1156913012410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913012411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913012412 ATP binding site [chemical binding]; other site 1156913012413 Mg2+ binding site [ion binding]; other site 1156913012414 G-X-G motif; other site 1156913012415 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1156913012416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913012417 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913012418 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913012419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913012420 Walker A/P-loop; other site 1156913012421 ATP binding site [chemical binding]; other site 1156913012422 Q-loop/lid; other site 1156913012423 ABC transporter signature motif; other site 1156913012424 Walker B; other site 1156913012425 D-loop; other site 1156913012426 H-loop/switch region; other site 1156913012427 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913012428 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913012429 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1156913012430 Walker A/P-loop; other site 1156913012431 ATP binding site [chemical binding]; other site 1156913012432 Q-loop/lid; other site 1156913012433 ABC transporter signature motif; other site 1156913012434 Walker B; other site 1156913012435 D-loop; other site 1156913012436 H-loop/switch region; other site 1156913012437 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1156913012438 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1156913012439 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1156913012440 active site 1156913012441 DNA binding site [nucleotide binding] 1156913012442 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1156913012443 DNA binding site [nucleotide binding] 1156913012444 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1156913012445 anti sigma factor interaction site; other site 1156913012446 regulatory phosphorylation site [posttranslational modification]; other site 1156913012447 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1156913012448 putative active site; other site 1156913012449 putative metal binding residues [ion binding]; other site 1156913012450 signature motif; other site 1156913012451 putative triphosphate binding site [ion binding]; other site 1156913012452 CHAD domain; Region: CHAD; pfam05235 1156913012453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913012454 non-specific DNA binding site [nucleotide binding]; other site 1156913012455 salt bridge; other site 1156913012456 sequence-specific DNA binding site [nucleotide binding]; other site 1156913012457 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1156913012458 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913012459 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1156913012460 NACHT domain; Region: NACHT; pfam05729 1156913012461 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913012462 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913012463 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1156913012464 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1156913012465 conserved cys residue [active] 1156913012466 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913012467 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1156913012468 conserved cys residue [active] 1156913012469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913012470 YibE/F-like protein; Region: YibE_F; pfam07907 1156913012471 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1156913012472 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1156913012473 active site 1156913012474 hypothetical protein; Provisional; Region: PRK09266 1156913012475 homodimer interface [polypeptide binding]; other site 1156913012476 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1156913012477 substrate-cofactor binding pocket; other site 1156913012478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913012479 catalytic residue [active] 1156913012480 amidase; Provisional; Region: PRK06170 1156913012481 Amidase; Region: Amidase; cl11426 1156913012482 enoyl-CoA hydratase; Provisional; Region: PRK06127 1156913012483 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913012484 substrate binding site [chemical binding]; other site 1156913012485 oxyanion hole (OAH) forming residues; other site 1156913012486 trimer interface [polypeptide binding]; other site 1156913012487 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1156913012488 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1156913012489 Zn2+ binding site [ion binding]; other site 1156913012490 Mg2+ binding site [ion binding]; other site 1156913012491 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1156913012492 synthetase active site [active] 1156913012493 NTP binding site [chemical binding]; other site 1156913012494 metal binding site [ion binding]; metal-binding site 1156913012495 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1156913012496 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1156913012497 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1156913012498 active site 1156913012499 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1156913012500 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1156913012501 Protein export membrane protein; Region: SecD_SecF; cl14618 1156913012502 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1156913012503 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1156913012504 Preprotein translocase subunit; Region: YajC; cl00806 1156913012505 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1156913012506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913012507 Walker A motif; other site 1156913012508 ATP binding site [chemical binding]; other site 1156913012509 Walker B motif; other site 1156913012510 arginine finger; other site 1156913012511 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1156913012512 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1156913012513 RuvA N terminal domain; Region: RuvA_N; pfam01330 1156913012514 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1156913012515 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1156913012516 active site 1156913012517 putative DNA-binding cleft [nucleotide binding]; other site 1156913012518 dimer interface [polypeptide binding]; other site 1156913012519 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 1156913012520 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1156913012521 hypothetical protein; Validated; Region: PRK00110 1156913012522 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1156913012523 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 1156913012524 predicted active site [active] 1156913012525 catalytic triad [active] 1156913012526 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1156913012527 AzlC protein; Region: AzlC; pfam03591 1156913012528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913012529 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913012530 non-specific DNA binding site [nucleotide binding]; other site 1156913012531 salt bridge; other site 1156913012532 sequence-specific DNA binding site [nucleotide binding]; other site 1156913012533 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1156913012534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913012535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913012536 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1156913012537 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1156913012538 homodimer interface [polypeptide binding]; other site 1156913012539 homotetramer interface [polypeptide binding]; other site 1156913012540 active site pocket [active] 1156913012541 cleavage site 1156913012542 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913012543 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913012544 AAA ATPase domain; Region: AAA_16; pfam13191 1156913012545 Beta/Gamma crystallin; Region: Crystall; cl02528 1156913012546 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1156913012547 CoenzymeA binding site [chemical binding]; other site 1156913012548 subunit interaction site [polypeptide binding]; other site 1156913012549 PHB binding site; other site 1156913012550 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1156913012551 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1156913012552 active site 1156913012553 multimer interface [polypeptide binding]; other site 1156913012554 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1156913012555 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913012556 Berberine and berberine like; Region: BBE; pfam08031 1156913012557 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1156913012558 elongation factor G; Reviewed; Region: PRK12740 1156913012559 G1 box; other site 1156913012560 putative GEF interaction site [polypeptide binding]; other site 1156913012561 GTP/Mg2+ binding site [chemical binding]; other site 1156913012562 Switch I region; other site 1156913012563 G2 box; other site 1156913012564 G3 box; other site 1156913012565 Switch II region; other site 1156913012566 G4 box; other site 1156913012567 G5 box; other site 1156913012568 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1156913012569 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1156913012570 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1156913012571 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1156913012572 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1156913012573 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1156913012574 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1156913012575 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1156913012576 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1156913012577 putative acyl-acceptor binding pocket; other site 1156913012578 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1156913012579 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913012580 MarR family; Region: MarR_2; pfam12802 1156913012581 MarR family; Region: MarR_2; cl17246 1156913012582 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1156913012583 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1156913012584 nucleotide binding site/active site [active] 1156913012585 HIT family signature motif; other site 1156913012586 catalytic residue [active] 1156913012587 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1156913012588 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1156913012589 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1156913012590 active site 1156913012591 dimer interface [polypeptide binding]; other site 1156913012592 motif 1; other site 1156913012593 motif 2; other site 1156913012594 motif 3; other site 1156913012595 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1156913012596 anticodon binding site; other site 1156913012597 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1156913012598 putative FMN binding site [chemical binding]; other site 1156913012599 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1156913012600 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1156913012601 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 1156913012602 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1156913012603 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1156913012604 active site 1156913012605 DNA binding site [nucleotide binding] 1156913012606 Int/Topo IB signature motif; other site 1156913012607 Helix-turn-helix domain; Region: HTH_17; pfam12728 1156913012608 DNA methylase; Region: N6_N4_Mtase; pfam01555 1156913012609 PrgI family protein; Region: PrgI; pfam12666 1156913012610 AAA-like domain; Region: AAA_10; pfam12846 1156913012611 Domain of unknown function DUF87; Region: DUF87; pfam01935 1156913012612 Domain of unknown function DUF87; Region: DUF87; pfam01935 1156913012613 AAA-like domain; Region: AAA_10; pfam12846 1156913012614 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1156913012615 Replication-relaxation; Region: Replic_Relax; pfam13814 1156913012616 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1156913012617 NlpC/P60 family; Region: NLPC_P60; pfam00877 1156913012618 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1156913012619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913012620 Walker A/P-loop; other site 1156913012621 ATP binding site [chemical binding]; other site 1156913012622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913012623 Walker B; other site 1156913012624 D-loop; other site 1156913012625 H-loop/switch region; other site 1156913012626 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1156913012627 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913012628 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1156913012629 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1156913012630 Type II/IV secretion system protein; Region: T2SE; pfam00437 1156913012631 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1156913012632 ATP binding site [chemical binding]; other site 1156913012633 Walker A motif; other site 1156913012634 hexamer interface [polypeptide binding]; other site 1156913012635 Walker B motif; other site 1156913012636 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1156913012637 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913012638 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913012639 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913012640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913012641 putative substrate translocation pore; other site 1156913012642 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913012643 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913012644 metal binding site [ion binding]; metal-binding site 1156913012645 active site 1156913012646 I-site; other site 1156913012647 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1156913012648 dimer interface [polypeptide binding]; other site 1156913012649 ADP-ribose binding site [chemical binding]; other site 1156913012650 active site 1156913012651 nudix motif; other site 1156913012652 metal binding site [ion binding]; metal-binding site 1156913012653 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913012654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913012655 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1156913012656 nudix motif; other site 1156913012657 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1156913012658 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913012659 FeS/SAM binding site; other site 1156913012660 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1156913012661 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1156913012662 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1156913012663 TMP-binding site; other site 1156913012664 ATP-binding site [chemical binding]; other site 1156913012665 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1156913012666 putative catalytic site [active] 1156913012667 putative metal binding site [ion binding]; other site 1156913012668 putative phosphate binding site [ion binding]; other site 1156913012669 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1156913012670 nudix motif; other site 1156913012671 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1156913012672 generic binding surface I; other site 1156913012673 generic binding surface II; other site 1156913012674 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1156913012675 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1156913012676 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1156913012677 DNA binding site [nucleotide binding] 1156913012678 active site 1156913012679 Int/Topo IB signature motif; other site 1156913012680 PHP domain; Region: PHP; pfam02811 1156913012681 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1156913012682 active site 1156913012683 PHP Thumb interface [polypeptide binding]; other site 1156913012684 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1156913012685 ANTAR domain; Region: ANTAR; pfam03861 1156913012686 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1156913012687 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1156913012688 active site 1156913012689 DNA binding site [nucleotide binding] 1156913012690 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 1156913012691 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1156913012692 DNA binding site [nucleotide binding] 1156913012693 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1156913012694 nucleotide binding site [chemical binding]; other site 1156913012695 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 1156913012696 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1156913012697 NB-ARC domain; Region: NB-ARC; pfam00931 1156913012698 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913012699 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1156913012700 galactokinase; Region: PLN02521 1156913012701 Short repeats of unknown function; Region: ALF; pfam03752 1156913012702 Short repeats of unknown function; Region: ALF; pfam03752 1156913012703 LGFP repeat; Region: LGFP; pfam08310 1156913012704 LGFP repeat; Region: LGFP; pfam08310 1156913012705 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1156913012706 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1156913012707 AAA ATPase domain; Region: AAA_16; pfam13191 1156913012708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913012709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913012710 DNA binding residues [nucleotide binding] 1156913012711 dimerization interface [polypeptide binding]; other site 1156913012712 MbtH-like protein; Region: MbtH; pfam03621 1156913012713 Condensation domain; Region: Condensation; pfam00668 1156913012714 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913012715 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913012716 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913012717 acyl-activating enzyme (AAE) consensus motif; other site 1156913012718 AMP binding site [chemical binding]; other site 1156913012719 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913012720 Condensation domain; Region: Condensation; pfam00668 1156913012721 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913012722 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913012723 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913012724 Condensation domain; Region: Condensation; pfam00668 1156913012725 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913012726 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913012727 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913012728 acyl-activating enzyme (AAE) consensus motif; other site 1156913012729 AMP binding site [chemical binding]; other site 1156913012730 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913012731 Condensation domain; Region: Condensation; pfam00668 1156913012732 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913012733 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913012734 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913012735 acyl-activating enzyme (AAE) consensus motif; other site 1156913012736 AMP binding site [chemical binding]; other site 1156913012737 Condensation domain; Region: Condensation; pfam00668 1156913012738 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913012739 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913012740 active site 1156913012741 CoA binding site [chemical binding]; other site 1156913012742 AMP binding site [chemical binding]; other site 1156913012743 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913012744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913012745 putative substrate translocation pore; other site 1156913012746 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913012747 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1156913012748 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1156913012749 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 1156913012750 Helix-turn-helix domain; Region: HTH_18; pfam12833 1156913012751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913012752 binding surface 1156913012753 TPR motif; other site 1156913012754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913012755 TPR motif; other site 1156913012756 binding surface 1156913012757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913012758 binding surface 1156913012759 TPR motif; other site 1156913012760 TPR repeat; Region: TPR_11; pfam13414 1156913012761 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1156913012762 PA14 domain; Region: PA14; cl08459 1156913012763 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1156913012764 NB-ARC domain; Region: NB-ARC; pfam00931 1156913012765 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913012766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913012767 binding surface 1156913012768 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913012769 TPR motif; other site 1156913012770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913012771 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913012772 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1156913012773 RNAase interaction site [polypeptide binding]; other site 1156913012774 MarR family; Region: MarR_2; pfam12802 1156913012775 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913012776 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913012777 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913012778 NAD(P) binding site [chemical binding]; other site 1156913012779 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 1156913012780 putative active site [active] 1156913012781 putative catalytic triad [active] 1156913012782 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1156913012783 catalytic residues [active] 1156913012784 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1156913012785 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1156913012786 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1156913012787 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1156913012788 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1156913012789 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1156913012790 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1156913012791 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1156913012792 MULE transposase domain; Region: MULE; pfam10551 1156913012793 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1156913012794 cyclase homology domain; Region: CHD; cd07302 1156913012795 metal binding site [ion binding]; metal-binding site 1156913012796 SEFIR domain; Region: SEFIR; pfam08357 1156913012797 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1156913012798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913012799 Walker A motif; other site 1156913012800 ATP binding site [chemical binding]; other site 1156913012801 Walker B motif; other site 1156913012802 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1156913012803 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913012804 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913012805 active site 1156913012806 ATP binding site [chemical binding]; other site 1156913012807 substrate binding site [chemical binding]; other site 1156913012808 activation loop (A-loop); other site 1156913012809 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913012810 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913012811 active site 1156913012812 ATP binding site [chemical binding]; other site 1156913012813 substrate binding site [chemical binding]; other site 1156913012814 activation loop (A-loop); other site 1156913012815 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913012816 DNA binding site [nucleotide binding] 1156913012817 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913012818 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1156913012819 CHAT domain; Region: CHAT; pfam12770 1156913012820 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1156913012821 active site 1156913012822 catalytic site [active] 1156913012823 substrate binding site [chemical binding]; other site 1156913012824 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 1156913012825 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913012826 putative NAD(P) binding site [chemical binding]; other site 1156913012827 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1156913012828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913012829 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913012830 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913012831 active site 1156913012832 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913012833 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1156913012834 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1156913012835 heme-binding site [chemical binding]; other site 1156913012836 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1156913012837 FAD binding pocket [chemical binding]; other site 1156913012838 FAD binding motif [chemical binding]; other site 1156913012839 phosphate binding motif [ion binding]; other site 1156913012840 beta-alpha-beta structure motif; other site 1156913012841 NAD binding pocket [chemical binding]; other site 1156913012842 Heme binding pocket [chemical binding]; other site 1156913012843 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913012844 Ligand Binding Site [chemical binding]; other site 1156913012845 Universal stress protein family; Region: Usp; pfam00582 1156913012846 Ligand Binding Site [chemical binding]; other site 1156913012847 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1156913012848 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1156913012849 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1156913012850 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1156913012851 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1156913012852 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1156913012853 Class I aldolases; Region: Aldolase_Class_I; cl17187 1156913012854 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 1156913012855 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1156913012856 catalytic Zn binding site [ion binding]; other site 1156913012857 structural Zn binding site [ion binding]; other site 1156913012858 NAD(P) binding site [chemical binding]; other site 1156913012859 FOG: CBS domain [General function prediction only]; Region: COG0517 1156913012860 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1156913012861 BON domain; Region: BON; pfam04972 1156913012862 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1156913012863 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1156913012864 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1156913012865 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1156913012866 FOG: CBS domain [General function prediction only]; Region: COG0517 1156913012867 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1156913012868 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1156913012869 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1156913012870 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1156913012871 Short C-terminal domain; Region: SHOCT; pfam09851 1156913012872 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1156913012873 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1156913012874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913012875 motif II; other site 1156913012876 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1156913012877 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913012878 Ligand Binding Site [chemical binding]; other site 1156913012879 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913012880 Ligand Binding Site [chemical binding]; other site 1156913012881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913012882 Coenzyme A binding pocket [chemical binding]; other site 1156913012883 Winged helix-turn helix; Region: HTH_29; pfam13551 1156913012884 Homeodomain-like domain; Region: HTH_23; cl17451 1156913012885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1156913012886 Integrase core domain; Region: rve; pfam00665 1156913012887 Integrase core domain; Region: rve_3; pfam13683 1156913012888 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1156913012889 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913012890 Beta-Casp domain; Region: Beta-Casp; smart01027 1156913012891 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1156913012892 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1156913012893 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913012894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913012895 active site 1156913012896 phosphorylation site [posttranslational modification] 1156913012897 intermolecular recognition site; other site 1156913012898 dimerization interface [polypeptide binding]; other site 1156913012899 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913012900 DNA binding residues [nucleotide binding] 1156913012901 dimerization interface [polypeptide binding]; other site 1156913012902 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1156913012903 GAF domain; Region: GAF; pfam01590 1156913012904 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1156913012905 GAF domain; Region: GAF_3; pfam13492 1156913012906 Histidine kinase; Region: HisKA_3; pfam07730 1156913012907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913012908 ATP binding site [chemical binding]; other site 1156913012909 Mg2+ binding site [ion binding]; other site 1156913012910 G-X-G motif; other site 1156913012911 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1156913012912 dimer interface [polypeptide binding]; other site 1156913012913 Nitroreductase family; Region: Nitroreductase; pfam00881 1156913012914 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1156913012915 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913012916 Ligand Binding Site [chemical binding]; other site 1156913012917 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1156913012918 FOG: CBS domain [General function prediction only]; Region: COG0517 1156913012919 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1156913012920 BON domain; Region: BON; pfam04972 1156913012921 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1156913012922 CoA binding domain; Region: CoA_binding_2; pfam13380 1156913012923 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1156913012924 FOG: CBS domain [General function prediction only]; Region: COG0517 1156913012925 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1156913012926 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913012927 Ligand Binding Site [chemical binding]; other site 1156913012928 Nitroreductase family; Region: Nitroreductase; pfam00881 1156913012929 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1156913012930 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913012931 Ligand Binding Site [chemical binding]; other site 1156913012932 Acetokinase family; Region: Acetate_kinase; cl17229 1156913012933 propionate/acetate kinase; Provisional; Region: PRK12379 1156913012934 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1156913012935 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1156913012936 putative dimer interface [polypeptide binding]; other site 1156913012937 putative phosphoketolase; Provisional; Region: PRK05261 1156913012938 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1156913012939 TPP-binding site; other site 1156913012940 XFP C-terminal domain; Region: XFP_C; pfam09363 1156913012941 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913012942 Ligand Binding Site [chemical binding]; other site 1156913012943 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1156913012944 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913012945 Ligand Binding Site [chemical binding]; other site 1156913012946 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913012947 Ligand Binding Site [chemical binding]; other site 1156913012948 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1156913012949 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1156913012950 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1156913012951 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1156913012952 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1156913012953 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913012954 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1156913012955 NAD(P) binding site [chemical binding]; other site 1156913012956 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 1156913012957 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1156913012958 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 1156913012959 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913012960 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913012961 active site 1156913012962 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913012963 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913012964 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913012965 Enoylreductase; Region: PKS_ER; smart00829 1156913012966 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1156913012967 NAD(P) binding site [chemical binding]; other site 1156913012968 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913012969 putative NADP binding site [chemical binding]; other site 1156913012970 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913012971 active site 1156913012972 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913012973 Thioesterase; Region: PKS_TE; smart00824 1156913012974 DNA binding site [nucleotide binding] 1156913012975 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913012976 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913012977 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913012978 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913012979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913012980 binding surface 1156913012981 TPR motif; other site 1156913012982 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913012983 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 1156913012984 Hemerythrin family; Region: Hemerythrin-like; cl15774 1156913012985 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1156913012986 Cupin superfamily protein; Region: Cupin_4; pfam08007 1156913012987 Cupin-like domain; Region: Cupin_8; pfam13621 1156913012988 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1156913012989 IncA protein; Region: IncA; pfam04156 1156913012990 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1156913012991 nudix motif; other site 1156913012992 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913012993 DNA binding site [nucleotide binding] 1156913012994 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913012995 AAA ATPase domain; Region: AAA_16; pfam13191 1156913012996 NB-ARC domain; Region: NB-ARC; pfam00931 1156913012997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913012998 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913012999 TPR motif; other site 1156913013000 binding surface 1156913013001 MbtH-like protein; Region: MbtH; cl01279 1156913013002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913013003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913013004 putative substrate translocation pore; other site 1156913013005 peptide synthase; Provisional; Region: PRK12467 1156913013006 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913013007 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913013008 acyl-activating enzyme (AAE) consensus motif; other site 1156913013009 AMP binding site [chemical binding]; other site 1156913013010 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913013011 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913013012 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913013013 acyl-activating enzyme (AAE) consensus motif; other site 1156913013014 AMP binding site [chemical binding]; other site 1156913013015 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913013016 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913013017 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913013018 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913013019 acyl-activating enzyme (AAE) consensus motif; other site 1156913013020 AMP binding site [chemical binding]; other site 1156913013021 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913013022 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913013023 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913013024 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913013025 acyl-activating enzyme (AAE) consensus motif; other site 1156913013026 AMP binding site [chemical binding]; other site 1156913013027 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913013028 Condensation domain; Region: Condensation; pfam00668 1156913013029 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913013030 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1156913013031 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913013032 acyl-activating enzyme (AAE) consensus motif; other site 1156913013033 AMP binding site [chemical binding]; other site 1156913013034 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913013035 Condensation domain; Region: Condensation; pfam00668 1156913013036 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913013037 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913013038 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913013039 acyl-activating enzyme (AAE) consensus motif; other site 1156913013040 AMP binding site [chemical binding]; other site 1156913013041 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913013042 Condensation domain; Region: Condensation; pfam00668 1156913013043 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913013044 Condensation domain; Region: Condensation; pfam00668 1156913013045 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913013046 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1156913013047 acyl-activating enzyme (AAE) consensus motif; other site 1156913013048 AMP binding site [chemical binding]; other site 1156913013049 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913013050 Condensation domain; Region: Condensation; pfam00668 1156913013051 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913013052 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913013053 Condensation domain; Region: Condensation; pfam00668 1156913013054 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913013055 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913013056 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913013057 acyl-activating enzyme (AAE) consensus motif; other site 1156913013058 AMP binding site [chemical binding]; other site 1156913013059 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913013060 Condensation domain; Region: Condensation; pfam00668 1156913013061 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1156913013062 Condensation domain; Region: Condensation; pfam00668 1156913013063 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913013064 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913013065 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913013066 acyl-activating enzyme (AAE) consensus motif; other site 1156913013067 AMP binding site [chemical binding]; other site 1156913013068 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913013069 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913013070 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913013071 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1156913013072 YCII-related domain; Region: YCII; pfam03795 1156913013073 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913013074 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913013075 active site 1156913013076 metal binding site [ion binding]; metal-binding site 1156913013077 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1156913013078 B12 binding domain; Region: B12-binding_2; pfam02607 1156913013079 B12 binding domain; Region: B12-binding; pfam02310 1156913013080 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1156913013081 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913013082 MarR family; Region: MarR; pfam01047 1156913013083 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1156913013084 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1156913013085 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1156913013086 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1156913013087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913013088 ATP binding site [chemical binding]; other site 1156913013089 Mg2+ binding site [ion binding]; other site 1156913013090 G-X-G motif; other site 1156913013091 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1156913013092 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1156913013093 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1156913013094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013096 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1156913013097 NAD(P) binding pocket [chemical binding]; other site 1156913013098 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1156913013099 anti sigma factor interaction site; other site 1156913013100 regulatory phosphorylation site [posttranslational modification]; other site 1156913013101 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1156913013102 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1156913013103 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1156913013104 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1156913013105 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1156913013106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913013107 S-adenosylmethionine binding site [chemical binding]; other site 1156913013108 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1156913013109 Survival protein SurE; Region: SurE; cl00448 1156913013110 Survival protein SurE; Region: SurE; cl00448 1156913013111 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1156913013112 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1156913013113 substrate binding site [chemical binding]; other site 1156913013114 ATP binding site [chemical binding]; other site 1156913013115 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1156913013116 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913013117 haloalkane dehalogenase; Provisional; Region: PRK03592 1156913013118 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913013119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913013120 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1156913013121 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1156913013122 NAD binding site [chemical binding]; other site 1156913013123 catalytic Zn binding site [ion binding]; other site 1156913013124 substrate binding site [chemical binding]; other site 1156913013125 structural Zn binding site [ion binding]; other site 1156913013126 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913013127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913013128 DNA binding residues [nucleotide binding] 1156913013129 AAA domain; Region: AAA_33; pfam13671 1156913013130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913013131 dimerization interface [polypeptide binding]; other site 1156913013132 putative DNA binding site [nucleotide binding]; other site 1156913013133 putative Zn2+ binding site [ion binding]; other site 1156913013134 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1156913013135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913013136 Coenzyme A binding pocket [chemical binding]; other site 1156913013137 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1156913013138 arsenical-resistance protein; Region: acr3; TIGR00832 1156913013139 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1156913013140 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1156913013141 active site 1156913013142 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913013143 dimerization interface [polypeptide binding]; other site 1156913013144 putative DNA binding site [nucleotide binding]; other site 1156913013145 putative Zn2+ binding site [ion binding]; other site 1156913013146 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1156913013147 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1156913013148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013150 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1156913013151 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1156913013152 NAD(P) binding site [chemical binding]; other site 1156913013153 catalytic residues [active] 1156913013154 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1156913013155 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1156913013156 NAD binding site [chemical binding]; other site 1156913013157 catalytic Zn binding site [ion binding]; other site 1156913013158 substrate binding site [chemical binding]; other site 1156913013159 structural Zn binding site [ion binding]; other site 1156913013160 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1156913013161 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1156913013162 acyl-activating enzyme (AAE) consensus motif; other site 1156913013163 putative AMP binding site [chemical binding]; other site 1156913013164 putative active site [active] 1156913013165 putative CoA binding site [chemical binding]; other site 1156913013166 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1156913013167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913013168 substrate binding site [chemical binding]; other site 1156913013169 oxyanion hole (OAH) forming residues; other site 1156913013170 trimer interface [polypeptide binding]; other site 1156913013171 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1156913013172 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1156913013173 catalytic triad [active] 1156913013174 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1156913013175 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1156913013176 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1156913013177 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913013178 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1156913013179 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1156913013180 substrate binding pocket [chemical binding]; other site 1156913013181 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1156913013182 RibD C-terminal domain; Region: RibD_C; cl17279 1156913013183 metabolite-proton symporter; Region: 2A0106; TIGR00883 1156913013184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913013185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913013186 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1156913013187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913013188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913013189 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1156913013190 putative dimerization interface [polypeptide binding]; other site 1156913013191 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1156913013192 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1156913013193 hypothetical protein; Provisional; Region: PRK06541 1156913013194 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913013195 inhibitor-cofactor binding pocket; inhibition site 1156913013196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913013197 catalytic residue [active] 1156913013198 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 1156913013199 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1156913013200 PYR/PP interface [polypeptide binding]; other site 1156913013201 dimer interface [polypeptide binding]; other site 1156913013202 TPP binding site [chemical binding]; other site 1156913013203 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1156913013204 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 1156913013205 TPP-binding site; other site 1156913013206 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913013207 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1156913013208 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913013209 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 1156913013210 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 1156913013211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1156913013212 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 1156913013213 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 1156913013214 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1156913013215 metal ion-dependent adhesion site (MIDAS); other site 1156913013216 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1156913013217 ligand binding site [chemical binding]; other site 1156913013218 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1156913013219 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1156913013220 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1156913013221 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1156913013222 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1156913013223 active site 1156913013224 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1156913013225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913013226 DNA-binding site [nucleotide binding]; DNA binding site 1156913013227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913013228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913013229 homodimer interface [polypeptide binding]; other site 1156913013230 catalytic residue [active] 1156913013231 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1156913013232 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1156913013233 hexamer interface [polypeptide binding]; other site 1156913013234 ligand binding site [chemical binding]; other site 1156913013235 putative active site [active] 1156913013236 NAD(P) binding site [chemical binding]; other site 1156913013237 Histidine kinase; Region: HisKA_3; pfam07730 1156913013238 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913013239 Mg2+ binding site [ion binding]; other site 1156913013240 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913013241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913013242 active site 1156913013243 phosphorylation site [posttranslational modification] 1156913013244 intermolecular recognition site; other site 1156913013245 dimerization interface [polypeptide binding]; other site 1156913013246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913013247 DNA binding residues [nucleotide binding] 1156913013248 dimerization interface [polypeptide binding]; other site 1156913013249 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1156913013250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913013251 Walker A/P-loop; other site 1156913013252 ATP binding site [chemical binding]; other site 1156913013253 Q-loop/lid; other site 1156913013254 ABC transporter signature motif; other site 1156913013255 Walker B; other site 1156913013256 D-loop; other site 1156913013257 H-loop/switch region; other site 1156913013258 Isochorismatase family; Region: Isochorismatase; pfam00857 1156913013259 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1156913013260 catalytic triad [active] 1156913013261 conserved cis-peptide bond; other site 1156913013262 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913013263 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1156913013264 putative hydrophobic ligand binding site [chemical binding]; other site 1156913013265 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1156913013266 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913013267 catalytic loop [active] 1156913013268 iron binding site [ion binding]; other site 1156913013269 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1156913013270 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1156913013271 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1156913013272 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1156913013273 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1156913013274 benzoate transport; Region: 2A0115; TIGR00895 1156913013275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913013276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913013277 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913013278 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1156913013279 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1156913013280 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1156913013281 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913013282 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1156913013283 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1156913013284 putative FMN binding site [chemical binding]; other site 1156913013285 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913013286 DNA binding site [nucleotide binding] 1156913013287 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913013288 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913013289 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913013290 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913013291 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913013292 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913013293 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1156913013294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913013295 salt bridge; other site 1156913013296 non-specific DNA binding site [nucleotide binding]; other site 1156913013297 sequence-specific DNA binding site [nucleotide binding]; other site 1156913013298 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1156913013299 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 1156913013300 Domain interface; other site 1156913013301 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 1156913013302 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1156913013303 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 1156913013304 starch-binding site 2 [chemical binding]; other site 1156913013305 starch-binding site 1 [chemical binding]; other site 1156913013306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013308 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913013309 Interdomain contacts; other site 1156913013310 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913013311 Interdomain contacts; other site 1156913013312 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913013313 Interdomain contacts; other site 1156913013314 Cytokine receptor motif; other site 1156913013315 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913013316 Interdomain contacts; other site 1156913013317 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913013318 Interdomain contacts; other site 1156913013319 Cytokine receptor motif; other site 1156913013320 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913013321 Interdomain contacts; other site 1156913013322 Cytokine receptor motif; other site 1156913013323 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1156913013324 Phosphotransferase enzyme family; Region: APH; pfam01636 1156913013325 putative active site [active] 1156913013326 putative substrate binding site [chemical binding]; other site 1156913013327 ATP binding site [chemical binding]; other site 1156913013328 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1156913013329 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1156913013330 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1156913013331 dimer interface [polypeptide binding]; other site 1156913013332 PYR/PP interface [polypeptide binding]; other site 1156913013333 TPP binding site [chemical binding]; other site 1156913013334 substrate binding site [chemical binding]; other site 1156913013335 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 1156913013336 TPP-binding site; other site 1156913013337 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1156913013338 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913013339 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913013340 putative DNA binding site [nucleotide binding]; other site 1156913013341 putative Zn2+ binding site [ion binding]; other site 1156913013342 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913013343 Predicted transcriptional regulator [Transcription]; Region: COG2378 1156913013344 HTH domain; Region: HTH_11; pfam08279 1156913013345 WYL domain; Region: WYL; pfam13280 1156913013346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913013347 Walker A/P-loop; other site 1156913013348 ATP binding site [chemical binding]; other site 1156913013349 Q-loop/lid; other site 1156913013350 ABC transporter; Region: ABC_tran; pfam00005 1156913013351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913013352 ABC transporter signature motif; other site 1156913013353 Walker B; other site 1156913013354 D-loop; other site 1156913013355 H-loop/switch region; other site 1156913013356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913013357 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1156913013358 Walker A/P-loop; other site 1156913013359 ATP binding site [chemical binding]; other site 1156913013360 Q-loop/lid; other site 1156913013361 ABC transporter signature motif; other site 1156913013362 Walker B; other site 1156913013363 D-loop; other site 1156913013364 H-loop/switch region; other site 1156913013365 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1156913013366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913013367 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1156913013368 Walker A/P-loop; other site 1156913013369 ATP binding site [chemical binding]; other site 1156913013370 Q-loop/lid; other site 1156913013371 ABC transporter signature motif; other site 1156913013372 Walker B; other site 1156913013373 D-loop; other site 1156913013374 H-loop/switch region; other site 1156913013375 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913013376 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1156913013377 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1156913013378 putative active site [active] 1156913013379 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913013380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913013381 S-adenosylmethionine binding site [chemical binding]; other site 1156913013382 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1156913013383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913013384 Walker A/P-loop; other site 1156913013385 ATP binding site [chemical binding]; other site 1156913013386 ABC transporter signature motif; other site 1156913013387 Walker B; other site 1156913013388 D-loop; other site 1156913013389 H-loop/switch region; other site 1156913013390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913013391 PRC-barrel domain; Region: PRC; pfam05239 1156913013392 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1156913013393 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913013394 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913013395 active site 1156913013396 ATP binding site [chemical binding]; other site 1156913013397 substrate binding site [chemical binding]; other site 1156913013398 activation loop (A-loop); other site 1156913013399 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1156913013400 Response regulator receiver domain; Region: Response_reg; pfam00072 1156913013401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913013402 active site 1156913013403 phosphorylation site [posttranslational modification] 1156913013404 intermolecular recognition site; other site 1156913013405 dimerization interface [polypeptide binding]; other site 1156913013406 CHASE3 domain; Region: CHASE3; pfam05227 1156913013407 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1156913013408 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1156913013409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913013410 dimer interface [polypeptide binding]; other site 1156913013411 phosphorylation site [posttranslational modification] 1156913013412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913013413 ATP binding site [chemical binding]; other site 1156913013414 Mg2+ binding site [ion binding]; other site 1156913013415 G-X-G motif; other site 1156913013416 Response regulator receiver domain; Region: Response_reg; pfam00072 1156913013417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913013418 active site 1156913013419 phosphorylation site [posttranslational modification] 1156913013420 intermolecular recognition site; other site 1156913013421 dimerization interface [polypeptide binding]; other site 1156913013422 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1156913013423 Integral membrane protein TerC family; Region: TerC; cl10468 1156913013424 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1156913013425 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913013426 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1156913013427 putative hydrophobic ligand binding site [chemical binding]; other site 1156913013428 MarR family; Region: MarR_2; pfam12802 1156913013429 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913013430 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1156913013431 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913013432 active site 1156913013433 TDP-binding site; other site 1156913013434 acceptor substrate-binding pocket; other site 1156913013435 homodimer interface [polypeptide binding]; other site 1156913013436 short chain dehydrogenase; Provisional; Region: PRK06914 1156913013437 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1156913013438 NADP binding site [chemical binding]; other site 1156913013439 active site 1156913013440 steroid binding site; other site 1156913013441 Putative esterase; Region: Esterase; pfam00756 1156913013442 acyl-CoA synthetase; Validated; Region: PRK05850 1156913013443 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1156913013444 acyl-activating enzyme (AAE) consensus motif; other site 1156913013445 active site 1156913013446 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913013447 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913013448 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1156913013449 active site 1156913013450 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1156913013451 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913013452 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913013453 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1156913013454 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1156913013455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913013456 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1156913013457 putative dimer interface [polypeptide binding]; other site 1156913013458 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913013459 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013461 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913013462 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913013463 active site 1156913013464 ATP binding site [chemical binding]; other site 1156913013465 substrate binding site [chemical binding]; other site 1156913013466 activation loop (A-loop); other site 1156913013467 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913013468 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913013469 active site 1156913013470 ATP binding site [chemical binding]; other site 1156913013471 substrate binding site [chemical binding]; other site 1156913013472 activation loop (A-loop); other site 1156913013473 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1156913013474 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1156913013475 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1156913013476 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913013477 Secretory lipase; Region: LIP; pfam03583 1156913013478 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913013479 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913013480 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913013481 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1156913013482 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913013483 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913013484 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913013485 mce related protein; Region: MCE; pfam02470 1156913013486 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913013487 mce related protein; Region: MCE; pfam02470 1156913013488 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1156913013489 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913013490 mce related protein; Region: MCE; pfam02470 1156913013491 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913013492 mce related protein; Region: MCE; pfam02470 1156913013493 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913013494 mce related protein; Region: MCE; pfam02470 1156913013495 mce related protein; Region: MCE; pfam02470 1156913013496 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1156913013497 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1156913013498 Permease; Region: Permease; pfam02405 1156913013499 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1156913013500 Permease; Region: Permease; pfam02405 1156913013501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913013502 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1156913013503 Walker A/P-loop; other site 1156913013504 ATP binding site [chemical binding]; other site 1156913013505 Q-loop/lid; other site 1156913013506 ABC transporter signature motif; other site 1156913013507 Walker B; other site 1156913013508 D-loop; other site 1156913013509 H-loop/switch region; other site 1156913013510 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1156913013511 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913013512 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1156913013513 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913013514 homodimer interface [polypeptide binding]; other site 1156913013515 active site 1156913013516 TDP-binding site; other site 1156913013517 acceptor substrate-binding pocket; other site 1156913013518 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913013519 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913013520 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913013521 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1156913013522 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913013523 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1156913013524 active site 1156913013525 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1156913013526 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1156913013527 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1156913013528 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1156913013529 phosphate binding site [ion binding]; other site 1156913013530 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913013531 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1156913013532 active site 1156913013533 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1156913013534 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1156913013535 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913013536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913013537 NAD(P) binding site [chemical binding]; other site 1156913013538 active site 1156913013539 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1156913013540 classical (c) SDRs; Region: SDR_c; cd05233 1156913013541 NAD(P) binding site [chemical binding]; other site 1156913013542 active site 1156913013543 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913013544 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913013545 active site 1156913013546 catalytic tetrad [active] 1156913013547 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1156913013548 Helix-turn-helix domain; Region: HTH_38; pfam13936 1156913013549 Integrase core domain; Region: rve; pfam00665 1156913013550 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1156913013551 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1156913013552 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1156913013553 NmrA-like family; Region: NmrA; pfam05368 1156913013554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913013555 NAD(P) binding site [chemical binding]; other site 1156913013556 active site 1156913013557 Predicted transcriptional regulator [Transcription]; Region: COG1959 1156913013558 Transcriptional regulator; Region: Rrf2; pfam02082 1156913013559 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1156913013560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913013561 NAD(P) binding site [chemical binding]; other site 1156913013562 active site 1156913013563 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1156913013564 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1156913013565 glycerol kinase; Provisional; Region: glpK; PRK00047 1156913013566 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913013567 nucleotide binding site [chemical binding]; other site 1156913013568 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1156913013569 amphipathic channel; other site 1156913013570 Asn-Pro-Ala signature motifs; other site 1156913013571 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1156913013572 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913013573 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913013574 glycerol kinase; Provisional; Region: glpK; PRK00047 1156913013575 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1156913013576 N- and C-terminal domain interface [polypeptide binding]; other site 1156913013577 active site 1156913013578 MgATP binding site [chemical binding]; other site 1156913013579 catalytic site [active] 1156913013580 metal binding site [ion binding]; metal-binding site 1156913013581 putative homotetramer interface [polypeptide binding]; other site 1156913013582 glycerol binding site [chemical binding]; other site 1156913013583 homodimer interface [polypeptide binding]; other site 1156913013584 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1156913013585 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913013586 active site 1156913013587 metal binding site [ion binding]; metal-binding site 1156913013588 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1156913013589 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1156913013590 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913013591 DNA binding residues [nucleotide binding] 1156913013592 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1156913013593 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1156913013594 Isochorismatase family; Region: Isochorismatase; pfam00857 1156913013595 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1156913013596 catalytic triad [active] 1156913013597 conserved cis-peptide bond; other site 1156913013598 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913013599 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1156913013600 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1156913013601 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 1156913013602 putative active site [active] 1156913013603 catalytic triad [active] 1156913013604 putative dimer interface [polypeptide binding]; other site 1156913013605 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1156913013606 DinB superfamily; Region: DinB_2; pfam12867 1156913013607 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1156913013608 HTH domain; Region: HTH_11; pfam08279 1156913013609 WYL domain; Region: WYL; pfam13280 1156913013610 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1156913013611 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1156913013612 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1156913013613 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1156913013614 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1156913013615 hydrophobic ligand binding site; other site 1156913013616 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1156913013617 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1156913013618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913013621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913013622 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1156913013623 putative dimerization interface [polypeptide binding]; other site 1156913013624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913013625 putative substrate translocation pore; other site 1156913013626 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1156913013627 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1156913013628 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913013629 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1156913013630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913013631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913013632 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1156913013633 dimerization interface [polypeptide binding]; other site 1156913013634 substrate binding pocket [chemical binding]; other site 1156913013635 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1156913013636 protein-export membrane protein SecD; Region: secD; TIGR01129 1156913013637 Protein export membrane protein; Region: SecD_SecF; cl14618 1156913013638 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1156913013639 Protein export membrane protein; Region: SecD_SecF; pfam02355 1156913013640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013642 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1156913013643 active site residue [active] 1156913013644 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913013645 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1156913013646 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1156913013647 homotrimer interaction site [polypeptide binding]; other site 1156913013648 putative active site [active] 1156913013649 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1156913013650 Domain of unknown function DUF11; Region: DUF11; pfam01345 1156913013651 Domain of unknown function DUF11; Region: DUF11; pfam01345 1156913013652 Domain of unknown function DUF11; Region: DUF11; pfam01345 1156913013653 Domain of unknown function DUF11; Region: DUF11; pfam01345 1156913013654 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1156913013655 Domain of unknown function DUF11; Region: DUF11; cl17728 1156913013656 Domain of unknown function DUF11; Region: DUF11; pfam01345 1156913013657 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1156913013658 Domain of unknown function DUF11; Region: DUF11; cl17728 1156913013659 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1156913013660 haloalkane dehalogenase; Provisional; Region: PRK03204 1156913013661 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1156913013662 catalytic site [active] 1156913013663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013664 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1156913013665 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1156913013666 calcium binding site 2 [ion binding]; other site 1156913013667 active site 1156913013668 catalytic triad [active] 1156913013669 calcium binding site 1 [ion binding]; other site 1156913013670 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1156913013671 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1156913013672 active site 1156913013673 substrate binding sites [chemical binding]; other site 1156913013674 AAA ATPase domain; Region: AAA_16; pfam13191 1156913013675 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913013676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913013677 DNA binding residues [nucleotide binding] 1156913013678 dimerization interface [polypeptide binding]; other site 1156913013679 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1156913013680 putative active site [active] 1156913013681 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1156913013682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1156913013683 short chain dehydrogenase; Provisional; Region: PRK07825 1156913013684 classical (c) SDRs; Region: SDR_c; cd05233 1156913013685 NAD(P) binding site [chemical binding]; other site 1156913013686 active site 1156913013687 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1156913013688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013690 Helix-turn-helix domain; Region: HTH_18; pfam12833 1156913013691 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1156913013692 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1156913013693 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1156913013694 active site 2 [active] 1156913013695 active site 1 [active] 1156913013696 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1156913013697 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1156913013698 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913013699 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913013700 active site 1156913013701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913013702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913013703 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1156913013704 putative dimerization interface [polypeptide binding]; other site 1156913013705 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1156913013706 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913013707 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1156913013708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913013709 putative substrate translocation pore; other site 1156913013710 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1156913013711 MULE transposase domain; Region: MULE; pfam10551 1156913013712 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913013713 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913013714 active site 1156913013715 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1156913013716 hypothetical protein; Provisional; Region: PRK07236 1156913013717 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913013718 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1156913013719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013720 Integral membrane protein TerC family; Region: TerC; cl10468 1156913013721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913013722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913013723 putative DNA binding site [nucleotide binding]; other site 1156913013724 putative Zn2+ binding site [ion binding]; other site 1156913013725 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1156913013726 putative dimerization interface [polypeptide binding]; other site 1156913013727 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1156913013728 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1156913013729 substrate-cofactor binding pocket; other site 1156913013730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913013731 catalytic residue [active] 1156913013732 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1156913013733 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913013734 NAD(P) binding site [chemical binding]; other site 1156913013735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913013736 Coenzyme A binding pocket [chemical binding]; other site 1156913013737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013739 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913013740 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913013741 Putative zinc-finger; Region: zf-HC2; pfam13490 1156913013742 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913013743 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1156913013744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913013745 Walker A/P-loop; other site 1156913013746 ATP binding site [chemical binding]; other site 1156913013747 Q-loop/lid; other site 1156913013748 ABC transporter signature motif; other site 1156913013749 Walker B; other site 1156913013750 D-loop; other site 1156913013751 H-loop/switch region; other site 1156913013752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013754 CAAX protease self-immunity; Region: Abi; pfam02517 1156913013755 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1156913013756 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1156913013757 putative NAD(P) binding site [chemical binding]; other site 1156913013758 putative substrate binding site [chemical binding]; other site 1156913013759 catalytic Zn binding site [ion binding]; other site 1156913013760 structural Zn binding site [ion binding]; other site 1156913013761 dimer interface [polypeptide binding]; other site 1156913013762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013764 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913013765 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1156913013766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913013769 S-adenosylmethionine binding site [chemical binding]; other site 1156913013770 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1156913013771 Predicted membrane protein [Function unknown]; Region: COG1511 1156913013772 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1156913013773 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1156913013774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913013775 Walker A/P-loop; other site 1156913013776 ATP binding site [chemical binding]; other site 1156913013777 Q-loop/lid; other site 1156913013778 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013779 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013780 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1156913013781 active site 1156913013782 zinc binding site [ion binding]; other site 1156913013783 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1156913013784 DNA binding site [nucleotide binding] 1156913013785 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913013786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913013787 binding surface 1156913013788 TPR motif; other site 1156913013789 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913013790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913013791 binding surface 1156913013792 TPR motif; other site 1156913013793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913013794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913013795 active site 1156913013796 phosphorylation site [posttranslational modification] 1156913013797 intermolecular recognition site; other site 1156913013798 dimerization interface [polypeptide binding]; other site 1156913013799 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913013800 DNA binding residues [nucleotide binding] 1156913013801 dimerization interface [polypeptide binding]; other site 1156913013802 Histidine kinase; Region: HisKA_3; pfam07730 1156913013803 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913013804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1156913013805 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1156913013806 active site 1156913013807 catalytic triad [active] 1156913013808 oxyanion hole [active] 1156913013809 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1156913013810 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913013811 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1156913013812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913013813 S-adenosylmethionine binding site [chemical binding]; other site 1156913013814 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1156913013815 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1156913013816 PYR/PP interface [polypeptide binding]; other site 1156913013817 dimer interface [polypeptide binding]; other site 1156913013818 TPP binding site [chemical binding]; other site 1156913013819 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1156913013820 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1156913013821 TPP-binding site [chemical binding]; other site 1156913013822 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1156913013823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913013824 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913013825 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913013826 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913013827 active site 1156913013828 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 1156913013829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1156913013830 Zn2+ binding site [ion binding]; other site 1156913013831 Mg2+ binding site [ion binding]; other site 1156913013832 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1156913013833 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1156913013834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913013835 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 1156913013836 active site 1156913013837 catalytic residues [active] 1156913013838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913013839 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1156913013840 DNA-binding site [nucleotide binding]; DNA binding site 1156913013841 UTRA domain; Region: UTRA; pfam07702 1156913013842 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1156913013843 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1156913013844 RNase_H superfamily; Region: RNase_H_2; pfam13482 1156913013845 AAA domain; Region: AAA_11; pfam13086 1156913013846 Part of AAA domain; Region: AAA_19; pfam13245 1156913013847 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1156913013848 AAA domain; Region: AAA_12; pfam13087 1156913013849 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913013850 DNA binding site [nucleotide binding] 1156913013851 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913013852 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913013853 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913013854 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1156913013855 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913013856 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1156913013857 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913013858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913013859 S-adenosylmethionine binding site [chemical binding]; other site 1156913013860 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913013861 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1156913013862 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1156913013863 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913013864 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913013865 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1156913013866 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1156913013867 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1156913013868 metal ion-dependent adhesion site (MIDAS); other site 1156913013869 PAS fold; Region: PAS; pfam00989 1156913013870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1156913013871 putative active site [active] 1156913013872 heme pocket [chemical binding]; other site 1156913013873 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913013874 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913013875 metal binding site [ion binding]; metal-binding site 1156913013876 active site 1156913013877 I-site; other site 1156913013878 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1156913013879 Cytochrome P450; Region: p450; cl12078 1156913013880 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913013881 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1156913013882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913013883 S-adenosylmethionine binding site [chemical binding]; other site 1156913013884 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913013885 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913013886 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1156913013887 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1156913013888 substrate binding site [chemical binding]; other site 1156913013889 catalytic residues [active] 1156913013890 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1156913013891 dimer interface [polypeptide binding]; other site 1156913013892 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1156913013893 NADP binding site [chemical binding]; other site 1156913013894 catalytic residues [active] 1156913013895 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1156913013896 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1156913013897 metal binding site [ion binding]; metal-binding site 1156913013898 substrate binding pocket [chemical binding]; other site 1156913013899 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1156913013900 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 1156913013901 catalytic residue [active] 1156913013902 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 1156913013903 Na binding site [ion binding]; other site 1156913013904 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1156913013905 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913013906 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913013907 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913013908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913013909 NAD(P) binding site [chemical binding]; other site 1156913013910 active site 1156913013911 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1156913013912 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913013913 MarR family; Region: MarR_2; pfam12802 1156913013914 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1156913013915 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913013916 DNA binding residues [nucleotide binding] 1156913013917 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1156913013918 active site 1156913013919 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1156913013920 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1156913013921 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1156913013922 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1156913013923 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1156913013924 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1156913013925 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1156913013926 Zn binding site [ion binding]; other site 1156913013927 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913013928 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913013929 acyl-activating enzyme (AAE) consensus motif; other site 1156913013930 AMP binding site [chemical binding]; other site 1156913013931 active site 1156913013932 CoA binding site [chemical binding]; other site 1156913013933 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913013934 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1156913013935 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1156913013936 active site 1156913013937 CoA binding site [chemical binding]; other site 1156913013938 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1156913013939 putative trimer interface [polypeptide binding]; other site 1156913013940 putative CoA binding site [chemical binding]; other site 1156913013941 GTP-binding protein Der; Reviewed; Region: PRK03003 1156913013942 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1156913013943 G1 box; other site 1156913013944 GTP/Mg2+ binding site [chemical binding]; other site 1156913013945 Switch I region; other site 1156913013946 G2 box; other site 1156913013947 Switch II region; other site 1156913013948 G3 box; other site 1156913013949 G4 box; other site 1156913013950 G5 box; other site 1156913013951 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1156913013952 G1 box; other site 1156913013953 GTP/Mg2+ binding site [chemical binding]; other site 1156913013954 Switch I region; other site 1156913013955 G2 box; other site 1156913013956 G3 box; other site 1156913013957 Switch II region; other site 1156913013958 G4 box; other site 1156913013959 G5 box; other site 1156913013960 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1156913013961 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1156913013962 putative acyl-acceptor binding pocket; other site 1156913013963 cytidylate kinase; Provisional; Region: cmk; PRK00023 1156913013964 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1156913013965 CMP-binding site; other site 1156913013966 The sites determining sugar specificity; other site 1156913013967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913013968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913013969 WHG domain; Region: WHG; pfam13305 1156913013970 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1156913013971 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1156913013972 TrkA-C domain; Region: TrkA_C; pfam02080 1156913013973 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1156913013974 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1156913013975 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1156913013976 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1156913013977 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1156913013978 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1156913013979 RNA binding surface [nucleotide binding]; other site 1156913013980 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1156913013981 active site 1156913013982 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1156913013983 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1156913013984 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1156913013985 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1156913013986 P-loop; other site 1156913013987 Magnesium ion binding site [ion binding]; other site 1156913013988 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1156913013989 Magnesium ion binding site [ion binding]; other site 1156913013990 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1156913013991 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1156913013992 active site 1156913013993 DNA binding site [nucleotide binding] 1156913013994 Int/Topo IB signature motif; other site 1156913013995 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1156913013996 TM2 domain; Region: TM2; pfam05154 1156913013997 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1156913013998 dimer interface [polypeptide binding]; other site 1156913013999 active site 1156913014000 ADP-ribose binding site [chemical binding]; other site 1156913014001 nudix motif; other site 1156913014002 metal binding site [ion binding]; metal-binding site 1156913014003 CTP synthetase; Validated; Region: pyrG; PRK05380 1156913014004 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1156913014005 active site 1156913014006 UTP binding site [chemical binding]; other site 1156913014007 Catalytic site [active] 1156913014008 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1156913014009 active site 1156913014010 putative oxyanion hole; other site 1156913014011 catalytic triad [active] 1156913014012 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1156913014013 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1156913014014 hinge; other site 1156913014015 active site 1156913014016 Phosphotransferase enzyme family; Region: APH; pfam01636 1156913014017 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1156913014018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913014019 DNA-binding site [nucleotide binding]; DNA binding site 1156913014020 FCD domain; Region: FCD; pfam07729 1156913014021 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1156913014022 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1156913014023 Na binding site [ion binding]; other site 1156913014024 putative substrate binding site [chemical binding]; other site 1156913014025 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1156913014026 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1156913014027 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1156913014028 Thiamine pyrophosphokinase; Region: TPK; cl08415 1156913014029 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1156913014030 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1156913014031 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1156913014032 Walker A/P-loop; other site 1156913014033 ATP binding site [chemical binding]; other site 1156913014034 Q-loop/lid; other site 1156913014035 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1156913014036 ABC transporter signature motif; other site 1156913014037 Walker B; other site 1156913014038 D-loop; other site 1156913014039 H-loop/switch region; other site 1156913014040 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1156913014041 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1156913014042 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1156913014043 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1156913014044 RNA binding surface [nucleotide binding]; other site 1156913014045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913014046 S-adenosylmethionine binding site [chemical binding]; other site 1156913014047 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1156913014048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913014049 active site 1156913014050 motif I; other site 1156913014051 motif II; other site 1156913014052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913014053 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1156913014054 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1156913014055 active site 1156913014056 HIGH motif; other site 1156913014057 dimer interface [polypeptide binding]; other site 1156913014058 KMSKS motif; other site 1156913014059 S4 RNA-binding domain; Region: S4; smart00363 1156913014060 RNA binding surface [nucleotide binding]; other site 1156913014061 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1156913014062 active site 1156913014063 DNA binding site [nucleotide binding] 1156913014064 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913014065 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913014066 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1156913014067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913014068 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913014069 argininosuccinate lyase; Provisional; Region: PRK00855 1156913014070 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1156913014071 active sites [active] 1156913014072 tetramer interface [polypeptide binding]; other site 1156913014073 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 1156913014074 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1156913014075 arginine repressor; Provisional; Region: PRK03341 1156913014076 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1156913014077 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1156913014078 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1156913014079 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1156913014080 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1156913014081 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913014082 inhibitor-cofactor binding pocket; inhibition site 1156913014083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913014084 catalytic residue [active] 1156913014085 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1156913014086 feedback inhibition sensing region; other site 1156913014087 homohexameric interface [polypeptide binding]; other site 1156913014088 nucleotide binding site [chemical binding]; other site 1156913014089 N-acetyl-L-glutamate binding site [chemical binding]; other site 1156913014090 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1156913014091 heterotetramer interface [polypeptide binding]; other site 1156913014092 active site pocket [active] 1156913014093 cleavage site 1156913014094 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1156913014095 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1156913014096 HTH domain; Region: HTH_11; pfam08279 1156913014097 Predicted transcriptional regulator [Transcription]; Region: COG2378 1156913014098 WYL domain; Region: WYL; pfam13280 1156913014099 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1156913014100 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913014101 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1156913014102 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1156913014103 active site 1156913014104 AAA ATPase domain; Region: AAA_16; pfam13191 1156913014105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913014106 TPR motif; other site 1156913014107 binding surface 1156913014108 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1156913014109 TPR repeat; Region: TPR_11; pfam13414 1156913014110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913014111 binding surface 1156913014112 TPR motif; other site 1156913014113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913014114 TPR motif; other site 1156913014115 TPR repeat; Region: TPR_11; pfam13414 1156913014116 binding surface 1156913014117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913014118 binding surface 1156913014119 TPR motif; other site 1156913014120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913014121 binding surface 1156913014122 TPR motif; other site 1156913014123 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1156913014124 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1156913014125 putative tRNA-binding site [nucleotide binding]; other site 1156913014126 B3/4 domain; Region: B3_4; pfam03483 1156913014127 tRNA synthetase B5 domain; Region: B5; smart00874 1156913014128 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1156913014129 dimer interface [polypeptide binding]; other site 1156913014130 motif 1; other site 1156913014131 motif 3; other site 1156913014132 motif 2; other site 1156913014133 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1156913014134 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1156913014135 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1156913014136 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1156913014137 dimer interface [polypeptide binding]; other site 1156913014138 motif 1; other site 1156913014139 active site 1156913014140 motif 2; other site 1156913014141 motif 3; other site 1156913014142 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1156913014143 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1156913014144 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1156913014145 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1156913014146 23S rRNA binding site [nucleotide binding]; other site 1156913014147 L21 binding site [polypeptide binding]; other site 1156913014148 L13 binding site [polypeptide binding]; other site 1156913014149 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1156913014150 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1156913014151 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1156913014152 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1156913014153 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1156913014154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913014155 DNA-binding site [nucleotide binding]; DNA binding site 1156913014156 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1156913014157 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1156913014158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913014159 catalytic residue [active] 1156913014160 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1156913014161 homotrimer interaction site [polypeptide binding]; other site 1156913014162 putative active site [active] 1156913014163 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913014164 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1156913014165 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913014166 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1156913014167 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1156913014168 substrate binding site [chemical binding]; other site 1156913014169 ATP binding site [chemical binding]; other site 1156913014170 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1156913014171 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1156913014172 dimer interface [polypeptide binding]; other site 1156913014173 active site 1156913014174 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1156913014175 substrate binding site [chemical binding]; other site 1156913014176 catalytic residue [active] 1156913014177 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1156913014178 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1156913014179 active site 1156913014180 putative substrate binding pocket [chemical binding]; other site 1156913014181 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913014182 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1156913014183 GntP family permease; Region: GntP_permease; pfam02447 1156913014184 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1156913014185 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913014186 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913014187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913014188 conserved gate region; other site 1156913014189 dimer interface [polypeptide binding]; other site 1156913014190 putative PBP binding loops; other site 1156913014191 ABC-ATPase subunit interface; other site 1156913014192 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913014193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913014194 dimer interface [polypeptide binding]; other site 1156913014195 conserved gate region; other site 1156913014196 putative PBP binding loops; other site 1156913014197 ABC-ATPase subunit interface; other site 1156913014198 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1156913014199 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1156913014200 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1156913014201 active site 1156913014202 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 1156913014203 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1156913014204 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 1156913014205 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913014206 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913014207 NAD(P) binding site [chemical binding]; other site 1156913014208 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1156913014209 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1156913014210 DNA binding residues [nucleotide binding] 1156913014211 putative dimer interface [polypeptide binding]; other site 1156913014212 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1156913014213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913014214 active site 1156913014215 phosphorylation site [posttranslational modification] 1156913014216 intermolecular recognition site; other site 1156913014217 dimerization interface [polypeptide binding]; other site 1156913014218 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1156913014219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913014220 ATP binding site [chemical binding]; other site 1156913014221 G-X-G motif; other site 1156913014222 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1156913014223 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1156913014224 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913014225 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913014226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913014227 putative substrate translocation pore; other site 1156913014228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913014229 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1156913014230 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1156913014231 active site 1156913014232 catalytic triad [active] 1156913014233 dimer interface [polypeptide binding]; other site 1156913014234 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1156913014235 hydrophobic ligand binding site; other site 1156913014236 Putative zinc-finger; Region: zf-HC2; pfam13490 1156913014237 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1156913014238 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913014239 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913014240 DNA binding residues [nucleotide binding] 1156913014241 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913014242 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1156913014243 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1156913014244 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1156913014245 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1156913014246 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1156913014247 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1156913014248 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1156913014249 oligomeric interface; other site 1156913014250 putative active site [active] 1156913014251 homodimer interface [polypeptide binding]; other site 1156913014252 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1156913014253 HEAT repeats; Region: HEAT_2; pfam13646 1156913014254 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 1156913014255 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913014256 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 1156913014257 Ca binding site [ion binding]; other site 1156913014258 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1156913014259 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 1156913014260 Ca binding site [ion binding]; other site 1156913014261 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1156913014262 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913014263 DNA binding residues [nucleotide binding] 1156913014264 drug binding residues [chemical binding]; other site 1156913014265 dimer interface [polypeptide binding]; other site 1156913014266 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1156913014267 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1156913014268 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1156913014269 putative active site [active] 1156913014270 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1156913014271 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1156913014272 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913014273 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913014274 active site 1156913014275 hypothetical protein; Provisional; Region: PRK07758 1156913014276 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1156913014277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1156913014278 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1156913014279 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1156913014280 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1156913014281 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 1156913014282 Ca binding site [ion binding]; other site 1156913014283 Ca binding site (active) [ion binding]; other site 1156913014284 ligand binding site [chemical binding]; other site 1156913014285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913014286 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913014287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913014288 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1156913014289 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913014290 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1156913014291 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 1156913014292 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913014293 catalytic core [active] 1156913014294 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1156913014295 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1156913014296 nudix motif; other site 1156913014297 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 1156913014298 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1156913014299 N- and C-terminal domain interface [polypeptide binding]; other site 1156913014300 putative active site [active] 1156913014301 MgATP binding site [chemical binding]; other site 1156913014302 catalytic site [active] 1156913014303 metal binding site [ion binding]; metal-binding site 1156913014304 putative xylulose binding site [chemical binding]; other site 1156913014305 putative homodimer interface [polypeptide binding]; other site 1156913014306 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913014307 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913014308 DNA binding site [nucleotide binding] 1156913014309 domain linker motif; other site 1156913014310 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1156913014311 dimerization interface [polypeptide binding]; other site 1156913014312 ligand binding site [chemical binding]; other site 1156913014313 RES domain; Region: RES; pfam08808 1156913014314 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1156913014315 GAF domain; Region: GAF; cl17456 1156913014316 ANTAR domain; Region: ANTAR; pfam03861 1156913014317 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1156913014318 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913014319 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1156913014320 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913014321 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913014322 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913014323 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1156913014324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913014325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913014326 Walker A/P-loop; other site 1156913014327 ATP binding site [chemical binding]; other site 1156913014328 Q-loop/lid; other site 1156913014329 ABC transporter signature motif; other site 1156913014330 Walker B; other site 1156913014331 D-loop; other site 1156913014332 H-loop/switch region; other site 1156913014333 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1156913014334 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1156913014335 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1156913014336 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913014337 substrate binding site [chemical binding]; other site 1156913014338 oxyanion hole (OAH) forming residues; other site 1156913014339 trimer interface [polypeptide binding]; other site 1156913014340 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 1156913014341 excinuclease ABC subunit B; Provisional; Region: PRK05298 1156913014342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913014343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913014344 nucleotide binding region [chemical binding]; other site 1156913014345 ATP-binding site [chemical binding]; other site 1156913014346 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1156913014347 UvrB/uvrC motif; Region: UVR; pfam02151 1156913014348 Protein of unknown function (DUF402); Region: DUF402; cl00979 1156913014349 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1156913014350 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1156913014351 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1156913014352 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1156913014353 CoA-binding site [chemical binding]; other site 1156913014354 ATP-binding [chemical binding]; other site 1156913014355 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1156913014356 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1156913014357 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1156913014358 RNA binding site [nucleotide binding]; other site 1156913014359 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1156913014360 RNA binding site [nucleotide binding]; other site 1156913014361 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1156913014362 RNA binding site [nucleotide binding]; other site 1156913014363 S1 RNA binding domain; Region: S1; pfam00575 1156913014364 RNA binding site [nucleotide binding]; other site 1156913014365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913014366 S-adenosylmethionine binding site [chemical binding]; other site 1156913014367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913014368 Coenzyme A binding pocket [chemical binding]; other site 1156913014369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913014370 Walker A/P-loop; other site 1156913014371 ATP binding site [chemical binding]; other site 1156913014372 Q-loop/lid; other site 1156913014373 Walker B; other site 1156913014374 D-loop; other site 1156913014375 H-loop/switch region; other site 1156913014376 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1156913014377 Predicted membrane protein [Function unknown]; Region: COG1511 1156913014378 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1156913014379 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1156913014380 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913014381 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913014382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913014383 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913014384 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913014385 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1156913014386 metal ion-dependent adhesion site (MIDAS); other site 1156913014387 Double zinc ribbon; Region: DZR; pfam12773 1156913014388 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913014389 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913014390 active site 1156913014391 ATP binding site [chemical binding]; other site 1156913014392 substrate binding site [chemical binding]; other site 1156913014393 activation loop (A-loop); other site 1156913014394 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1156913014395 DNA polymerase I; Provisional; Region: PRK05755 1156913014396 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1156913014397 active site 1156913014398 metal binding site 1 [ion binding]; metal-binding site 1156913014399 putative 5' ssDNA interaction site; other site 1156913014400 metal binding site 3; metal-binding site 1156913014401 metal binding site 2 [ion binding]; metal-binding site 1156913014402 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1156913014403 putative DNA binding site [nucleotide binding]; other site 1156913014404 putative metal binding site [ion binding]; other site 1156913014405 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1156913014406 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1156913014407 active site 1156913014408 DNA binding site [nucleotide binding] 1156913014409 catalytic site [active] 1156913014410 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1156913014411 CoenzymeA binding site [chemical binding]; other site 1156913014412 subunit interaction site [polypeptide binding]; other site 1156913014413 PHB binding site; other site 1156913014414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913014415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913014416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913014417 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1156913014418 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1156913014419 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1156913014420 dimerization interface [polypeptide binding]; other site 1156913014421 ligand binding site [chemical binding]; other site 1156913014422 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1156913014423 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913014424 TM-ABC transporter signature motif; other site 1156913014425 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1156913014426 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1156913014427 TM-ABC transporter signature motif; other site 1156913014428 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1156913014429 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1156913014430 Walker A/P-loop; other site 1156913014431 ATP binding site [chemical binding]; other site 1156913014432 Q-loop/lid; other site 1156913014433 ABC transporter signature motif; other site 1156913014434 Walker B; other site 1156913014435 D-loop; other site 1156913014436 H-loop/switch region; other site 1156913014437 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1156913014438 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1156913014439 Walker A/P-loop; other site 1156913014440 ATP binding site [chemical binding]; other site 1156913014441 Q-loop/lid; other site 1156913014442 ABC transporter signature motif; other site 1156913014443 Walker B; other site 1156913014444 D-loop; other site 1156913014445 H-loop/switch region; other site 1156913014446 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1156913014447 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1156913014448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913014449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913014450 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913014451 dimerization interface [polypeptide binding]; other site 1156913014452 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913014453 MarR family; Region: MarR_2; pfam12802 1156913014454 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1156913014455 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1156913014456 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1156913014457 active site 1156913014458 catalytic site [active] 1156913014459 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1156913014460 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1156913014461 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1156913014462 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1156913014463 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1156913014464 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1156913014465 TPR repeat; Region: TPR_11; pfam13414 1156913014466 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1156913014467 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1156913014468 Walker A/P-loop; other site 1156913014469 ATP binding site [chemical binding]; other site 1156913014470 Q-loop/lid; other site 1156913014471 ABC transporter signature motif; other site 1156913014472 Walker B; other site 1156913014473 D-loop; other site 1156913014474 H-loop/switch region; other site 1156913014475 TOBE domain; Region: TOBE_2; pfam08402 1156913014476 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913014477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913014478 dimer interface [polypeptide binding]; other site 1156913014479 conserved gate region; other site 1156913014480 putative PBP binding loops; other site 1156913014481 ABC-ATPase subunit interface; other site 1156913014482 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1156913014483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913014484 dimer interface [polypeptide binding]; other site 1156913014485 conserved gate region; other site 1156913014486 putative PBP binding loops; other site 1156913014487 ABC-ATPase subunit interface; other site 1156913014488 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913014489 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1156913014490 intersubunit interface [polypeptide binding]; other site 1156913014491 active site 1156913014492 zinc binding site [ion binding]; other site 1156913014493 Na+ binding site [ion binding]; other site 1156913014494 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1156913014495 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1156913014496 putative substrate binding site [chemical binding]; other site 1156913014497 putative ATP binding site [chemical binding]; other site 1156913014498 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1156913014499 dimer interface [polypeptide binding]; other site 1156913014500 active site 1156913014501 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1156913014502 dimer interface [polypeptide binding]; other site 1156913014503 active site 1156913014504 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1156913014505 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1156913014506 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 1156913014507 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1156913014508 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1156913014509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913014510 DNA-binding site [nucleotide binding]; DNA binding site 1156913014511 UTRA domain; Region: UTRA; pfam07702 1156913014512 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1156913014513 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1156913014514 tetrameric interface [polypeptide binding]; other site 1156913014515 NAD binding site [chemical binding]; other site 1156913014516 catalytic residues [active] 1156913014517 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1156913014518 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1156913014519 glutaminase; Provisional; Region: PRK00971 1156913014520 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1156913014521 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1156913014522 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913014523 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913014524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913014525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913014526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913014527 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1156913014528 dimerization interface [polypeptide binding]; other site 1156913014529 substrate binding pocket [chemical binding]; other site 1156913014530 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1156913014531 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1156913014532 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1156913014533 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1156913014534 metal ion-dependent adhesion site (MIDAS); other site 1156913014535 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1156913014536 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1156913014537 active site 1156913014538 HIGH motif; other site 1156913014539 nucleotide binding site [chemical binding]; other site 1156913014540 active site 1156913014541 KMSKS motif; other site 1156913014542 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1156913014543 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1156913014544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913014545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913014546 WHG domain; Region: WHG; pfam13305 1156913014547 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1156913014548 hydrophobic ligand binding site; other site 1156913014549 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1156913014550 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1156913014551 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1156913014552 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1156913014553 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913014554 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913014555 DNA binding residues [nucleotide binding] 1156913014556 dimerization interface [polypeptide binding]; other site 1156913014557 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913014558 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913014559 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1156913014560 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1156913014561 Walker A/P-loop; other site 1156913014562 ATP binding site [chemical binding]; other site 1156913014563 Q-loop/lid; other site 1156913014564 ABC transporter signature motif; other site 1156913014565 Walker B; other site 1156913014566 D-loop; other site 1156913014567 H-loop/switch region; other site 1156913014568 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913014569 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1156913014570 Walker A/P-loop; other site 1156913014571 ATP binding site [chemical binding]; other site 1156913014572 Q-loop/lid; other site 1156913014573 ABC transporter signature motif; other site 1156913014574 Walker B; other site 1156913014575 D-loop; other site 1156913014576 H-loop/switch region; other site 1156913014577 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1156913014578 TM-ABC transporter signature motif; other site 1156913014579 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1156913014580 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1156913014581 TM-ABC transporter signature motif; other site 1156913014582 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1156913014583 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1156913014584 fumarylacetoacetase; Region: PLN02856 1156913014585 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1156913014586 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1156913014587 MarR family; Region: MarR; pfam01047 1156913014588 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1156913014589 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1156913014590 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1156913014591 active site 1156913014592 FMN binding site [chemical binding]; other site 1156913014593 substrate binding site [chemical binding]; other site 1156913014594 putative catalytic residue [active] 1156913014595 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1156913014596 active site 1156913014597 catalytic site [active] 1156913014598 Zn binding site [ion binding]; other site 1156913014599 tetramer interface [polypeptide binding]; other site 1156913014600 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1156913014601 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1156913014602 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913014603 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913014604 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913014605 active site 1156913014606 ATP binding site [chemical binding]; other site 1156913014607 substrate binding site [chemical binding]; other site 1156913014608 activation loop (A-loop); other site 1156913014609 Clp protease; Region: CLP_protease; pfam00574 1156913014610 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1156913014611 oligomer interface [polypeptide binding]; other site 1156913014612 active site residues [active] 1156913014613 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1156913014614 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1156913014615 oligomer interface [polypeptide binding]; other site 1156913014616 active site residues [active] 1156913014617 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913014618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913014619 non-specific DNA binding site [nucleotide binding]; other site 1156913014620 salt bridge; other site 1156913014621 sequence-specific DNA binding site [nucleotide binding]; other site 1156913014622 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1156913014623 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913014624 conserved cys residue [active] 1156913014625 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913014626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913014627 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1156913014628 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1156913014629 CsbD-like; Region: CsbD; pfam05532 1156913014630 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1156913014631 EF-hand domain pair; Region: EF_hand_5; pfam13499 1156913014632 Ca2+ binding site [ion binding]; other site 1156913014633 EF-hand domain pair; Region: EF_hand_5; pfam13499 1156913014634 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1156913014635 Ca2+ binding site [ion binding]; other site 1156913014636 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1156913014637 EF-hand domain pair; Region: EF_hand_5; pfam13499 1156913014638 Ca2+ binding site [ion binding]; other site 1156913014639 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913014640 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913014641 DNA binding residues [nucleotide binding] 1156913014642 dimerization interface [polypeptide binding]; other site 1156913014643 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913014644 DNA binding site [nucleotide binding] 1156913014645 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913014646 AAA ATPase domain; Region: AAA_16; pfam13191 1156913014647 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913014648 DNA binding site [nucleotide binding] 1156913014649 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913014650 Predicted ATPase [General function prediction only]; Region: COG3899 1156913014651 AAA ATPase domain; Region: AAA_16; pfam13191 1156913014652 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913014653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913014654 DNA binding residues [nucleotide binding] 1156913014655 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913014656 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913014657 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1156913014658 beta-galactosidase; Region: BGL; TIGR03356 1156913014659 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913014660 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913014661 active site 1156913014662 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1156913014663 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1156913014664 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1156913014665 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1156913014666 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1156913014667 carboxyltransferase (CT) interaction site; other site 1156913014668 biotinylation site [posttranslational modification]; other site 1156913014669 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1156913014670 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1156913014671 Bifunctional nuclease; Region: DNase-RNase; cl00553 1156913014672 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1156913014673 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1156913014674 D-pathway; other site 1156913014675 Putative ubiquinol binding site [chemical binding]; other site 1156913014676 Low-spin heme (heme b) binding site [chemical binding]; other site 1156913014677 Putative water exit pathway; other site 1156913014678 Binuclear center (heme o3/CuB) [ion binding]; other site 1156913014679 K-pathway; other site 1156913014680 Putative proton exit pathway; other site 1156913014681 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913014682 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913014683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913014684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913014685 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1156913014686 putative dimerization interface [polypeptide binding]; other site 1156913014687 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1156913014688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913014689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913014690 putative substrate translocation pore; other site 1156913014691 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1156913014692 EamA-like transporter family; Region: EamA; pfam00892 1156913014693 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1156913014694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913014695 DNA-binding site [nucleotide binding]; DNA binding site 1156913014696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913014697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913014698 homodimer interface [polypeptide binding]; other site 1156913014699 catalytic residue [active] 1156913014700 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1156913014701 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1156913014702 ligand binding site [chemical binding]; other site 1156913014703 flexible hinge region; other site 1156913014704 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1156913014705 putative switch regulator; other site 1156913014706 non-specific DNA interactions [nucleotide binding]; other site 1156913014707 DNA binding site [nucleotide binding] 1156913014708 sequence specific DNA binding site [nucleotide binding]; other site 1156913014709 putative cAMP binding site [chemical binding]; other site 1156913014710 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1156913014711 catalytic site [active] 1156913014712 BNR repeat-like domain; Region: BNR_2; pfam13088 1156913014713 Asp-box motif; other site 1156913014714 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913014715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913014716 putative substrate translocation pore; other site 1156913014717 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1156913014718 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1156913014719 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 1156913014720 active site 1156913014721 dimer interface [polypeptide binding]; other site 1156913014722 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1156913014723 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1156913014724 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1156913014725 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1156913014726 nucleotide binding site [chemical binding]; other site 1156913014727 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1156913014728 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1156913014729 active site 1156913014730 DNA binding site [nucleotide binding] 1156913014731 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1156913014732 DNA binding site [nucleotide binding] 1156913014733 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1156913014734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913014735 putative substrate translocation pore; other site 1156913014736 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 1156913014737 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1156913014738 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1156913014739 AAA ATPase domain; Region: AAA_16; pfam13191 1156913014740 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913014741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913014742 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913014743 DNA binding residues [nucleotide binding] 1156913014744 dimerization interface [polypeptide binding]; other site 1156913014745 YceI-like domain; Region: YceI; pfam04264 1156913014746 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913014747 MarR family; Region: MarR; pfam01047 1156913014748 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1156913014749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913014750 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913014751 DNA binding residues [nucleotide binding] 1156913014752 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913014753 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1156913014754 Helix-turn-helix domain; Region: HTH_18; pfam12833 1156913014755 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1156913014756 cleavage site 1156913014757 active site 1156913014758 substrate binding sites [chemical binding]; other site 1156913014759 acyl-CoA synthetase; Provisional; Region: PRK13383 1156913014760 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1156913014761 acyl-activating enzyme (AAE) consensus motif; other site 1156913014762 AMP binding site [chemical binding]; other site 1156913014763 active site 1156913014764 CoA binding site [chemical binding]; other site 1156913014765 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1156913014766 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1156913014767 hypothetical protein; Provisional; Region: PRK08317 1156913014768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913014769 S-adenosylmethionine binding site [chemical binding]; other site 1156913014770 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1156913014771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913014772 acyl-activating enzyme (AAE) consensus motif; other site 1156913014773 AMP binding site [chemical binding]; other site 1156913014774 active site 1156913014775 CoA binding site [chemical binding]; other site 1156913014776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913014777 UbiA prenyltransferase family; Region: UbiA; pfam01040 1156913014778 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 1156913014779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913014780 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1156913014781 S-adenosylmethionine binding site [chemical binding]; other site 1156913014782 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1156913014783 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1156913014784 inhibitor-cofactor binding pocket; inhibition site 1156913014785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913014786 catalytic residue [active] 1156913014787 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1156913014788 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1156913014789 inhibitor-cofactor binding pocket; inhibition site 1156913014790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913014791 catalytic residue [active] 1156913014792 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913014793 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1156913014794 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1156913014795 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 1156913014796 metal binding site [ion binding]; metal-binding site 1156913014797 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1156913014798 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1156913014799 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913014800 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1156913014801 EF-hand domain pair; Region: EF_hand_5; pfam13499 1156913014802 Ca2+ binding site [ion binding]; other site 1156913014803 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1156913014804 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1156913014805 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1156913014806 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1156913014807 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1156913014808 substrate binding site [chemical binding]; other site 1156913014809 ATP binding site [chemical binding]; other site 1156913014810 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1156913014811 active site 1156913014812 substrate binding pocket [chemical binding]; other site 1156913014813 homodimer interaction site [polypeptide binding]; other site 1156913014814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1156913014815 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1156913014816 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1156913014817 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913014818 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913014819 DNA binding site [nucleotide binding] 1156913014820 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1156913014821 ligand binding site [chemical binding]; other site 1156913014822 dimerization interface [polypeptide binding]; other site 1156913014823 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1156913014824 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1156913014825 metal binding site [ion binding]; metal-binding site 1156913014826 dimer interface [polypeptide binding]; other site 1156913014827 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913014828 enoyl-CoA hydratase; Provisional; Region: PRK06494 1156913014829 substrate binding site [chemical binding]; other site 1156913014830 oxyanion hole (OAH) forming residues; other site 1156913014831 trimer interface [polypeptide binding]; other site 1156913014832 HTH domain; Region: HTH_11; pfam08279 1156913014833 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913014834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913014835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913014836 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1156913014837 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913014838 NAD binding site [chemical binding]; other site 1156913014839 catalytic residues [active] 1156913014840 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1156913014841 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1156913014842 dimer interface [polypeptide binding]; other site 1156913014843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913014844 catalytic residue [active] 1156913014845 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1156913014846 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1156913014847 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1156913014848 tetramer interface [polypeptide binding]; other site 1156913014849 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913014850 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913014851 acyl-activating enzyme (AAE) consensus motif; other site 1156913014852 AMP binding site [chemical binding]; other site 1156913014853 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913014854 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1156913014855 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913014856 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1156913014857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913014858 homodimer interface [polypeptide binding]; other site 1156913014859 catalytic residue [active] 1156913014860 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1156913014861 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913014862 substrate binding site [chemical binding]; other site 1156913014863 oxyanion hole (OAH) forming residues; other site 1156913014864 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1156913014865 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913014866 trimer interface [polypeptide binding]; other site 1156913014867 oxyanion hole (OAH) forming residues; other site 1156913014868 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1156913014869 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1156913014870 malonyl-CoA binding site [chemical binding]; other site 1156913014871 dimer interface [polypeptide binding]; other site 1156913014872 active site 1156913014873 product binding site; other site 1156913014874 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913014875 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913014876 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1156913014877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913014878 catalytic residue [active] 1156913014879 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1156913014880 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1156913014881 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1156913014882 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1156913014883 Condensation domain; Region: Condensation; pfam00668 1156913014884 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913014885 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913014886 Cupin domain; Region: Cupin_2; cl17218 1156913014887 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1156913014888 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913014889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913014890 homodimer interface [polypeptide binding]; other site 1156913014891 catalytic residue [active] 1156913014892 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913014893 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913014894 acyl-activating enzyme (AAE) consensus motif; other site 1156913014895 AMP binding site [chemical binding]; other site 1156913014896 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913014897 Condensation domain; Region: Condensation; pfam00668 1156913014898 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913014899 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1156913014900 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1156913014901 acyl-activating enzyme (AAE) consensus motif; other site 1156913014902 AMP binding site [chemical binding]; other site 1156913014903 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913014904 Condensation domain; Region: Condensation; pfam00668 1156913014905 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913014906 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913014907 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913014908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913014909 non-specific DNA binding site [nucleotide binding]; other site 1156913014910 salt bridge; other site 1156913014911 sequence-specific DNA binding site [nucleotide binding]; other site 1156913014912 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913014913 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913014914 acyl-activating enzyme (AAE) consensus motif; other site 1156913014915 AMP binding site [chemical binding]; other site 1156913014916 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913014917 Thioesterase domain; Region: Thioesterase; pfam00975 1156913014918 Condensation domain; Region: Condensation; pfam00668 1156913014919 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1156913014920 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1156913014921 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913014922 Condensation domain; Region: Condensation; pfam00668 1156913014923 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913014924 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913014925 acyl-activating enzyme (AAE) consensus motif; other site 1156913014926 AMP binding site [chemical binding]; other site 1156913014927 active site 1156913014928 CoA binding site [chemical binding]; other site 1156913014929 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913014930 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1156913014931 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913014932 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913014933 acyl-activating enzyme (AAE) consensus motif; other site 1156913014934 AMP binding site [chemical binding]; other site 1156913014935 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913014936 ParB-like nuclease domain; Region: ParB; smart00470 1156913014937 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1156913014938 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913014939 DNA binding site [nucleotide binding] 1156913014940 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913014941 NB-ARC domain; Region: NB-ARC; pfam00931 1156913014942 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 1156913014943 putative substrate binding site [chemical binding]; other site 1156913014944 active site 1156913014945 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1156913014946 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913014947 Ligand Binding Site [chemical binding]; other site 1156913014948 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913014949 Ligand Binding Site [chemical binding]; other site 1156913014950 glutamate carboxypeptidase; Reviewed; Region: PRK06133 1156913014951 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1156913014952 metal binding site [ion binding]; metal-binding site 1156913014953 dimer interface [polypeptide binding]; other site 1156913014954 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1156913014955 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1156913014956 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913014957 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1156913014958 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913014959 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913014960 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1156913014961 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913014962 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1156913014963 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913014964 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913014965 acyl-activating enzyme (AAE) consensus motif; other site 1156913014966 AMP binding site [chemical binding]; other site 1156913014967 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1156913014968 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1156913014969 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1156913014970 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1156913014971 tyrosine phenol-lyase; Provisional; Region: PRK13237 1156913014972 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913014973 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913014974 catalytic residue [active] 1156913014975 Helix-turn-helix domain; Region: HTH_18; pfam12833 1156913014976 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913014977 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1156913014978 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1156913014979 putative trimer interface [polypeptide binding]; other site 1156913014980 putative CoA binding site [chemical binding]; other site 1156913014981 Caspase domain; Region: Peptidase_C14; pfam00656 1156913014982 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1156913014983 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1156913014984 Zn binding sites [ion binding]; other site 1156913014985 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1156913014986 dimer interface [polypeptide binding]; other site 1156913014987 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1156913014988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913014989 active site 1156913014990 phosphorylation site [posttranslational modification] 1156913014991 intermolecular recognition site; other site 1156913014992 dimerization interface [polypeptide binding]; other site 1156913014993 ANTAR domain; Region: ANTAR; pfam03861 1156913014994 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913014995 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913014996 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913014997 NAD(P) binding site [chemical binding]; other site 1156913014998 catalytic residues [active] 1156913014999 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1156913015000 short chain dehydrogenase; Validated; Region: PRK06182 1156913015001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913015002 NAD(P) binding site [chemical binding]; other site 1156913015003 active site 1156913015004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913015005 Transposase; Region: HTH_Tnp_1; cl17663 1156913015006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1156913015007 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1156913015008 active sites [active] 1156913015009 tetramer interface [polypeptide binding]; other site 1156913015010 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913015011 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1156913015012 NAD(P) binding site [chemical binding]; other site 1156913015013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913015014 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913015015 active site 1156913015016 catalytic tetrad [active] 1156913015017 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1156913015018 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913015019 acyl-activating enzyme (AAE) consensus motif; other site 1156913015020 AMP binding site [chemical binding]; other site 1156913015021 active site 1156913015022 CoA binding site [chemical binding]; other site 1156913015023 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913015024 Thioesterase; Region: PKS_TE; smart00824 1156913015025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913015026 DNA-binding site [nucleotide binding]; DNA binding site 1156913015027 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1156913015028 putative transporter; Provisional; Region: PRK10504 1156913015029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913015030 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1156913015031 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913015032 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1156913015033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913015034 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913015035 NAD(P) binding site [chemical binding]; other site 1156913015036 active site 1156913015037 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1156913015038 nudix motif; other site 1156913015039 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1156913015040 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1156913015041 acyl-activating enzyme (AAE) consensus motif; other site 1156913015042 putative AMP binding site [chemical binding]; other site 1156913015043 putative active site [active] 1156913015044 putative CoA binding site [chemical binding]; other site 1156913015045 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1156913015046 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913015047 acyl-activating enzyme (AAE) consensus motif; other site 1156913015048 AMP binding site [chemical binding]; other site 1156913015049 active site 1156913015050 CoA binding site [chemical binding]; other site 1156913015051 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913015052 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913015053 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913015054 active site 1156913015055 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913015056 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913015057 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1156913015058 putative NADP binding site [chemical binding]; other site 1156913015059 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913015060 active site 1156913015061 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913015062 Thioesterase; Region: PKS_TE; smart00824 1156913015063 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913015064 active site 1156913015065 TDP-binding site; other site 1156913015066 acceptor substrate-binding pocket; other site 1156913015067 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1156913015068 dimer interface [polypeptide binding]; other site 1156913015069 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1156913015070 active site 1156913015071 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1156913015072 Ligand Binding Site [chemical binding]; other site 1156913015073 Molecular Tunnel; other site 1156913015074 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913015075 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1156913015076 active site 1156913015077 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1156913015078 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913015079 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913015080 active site 1156913015081 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1156913015082 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913015083 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1156913015084 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913015085 putative NADP binding site [chemical binding]; other site 1156913015086 active site 1156913015087 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913015088 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913015089 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913015090 active site 1156913015091 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1156913015092 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913015093 catalytic loop [active] 1156913015094 iron binding site [ion binding]; other site 1156913015095 acyltransferase PapA5; Provisional; Region: PRK09294 1156913015096 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1156913015097 classical (c) SDRs; Region: SDR_c; cd05233 1156913015098 NAD(P) binding site [chemical binding]; other site 1156913015099 active site 1156913015100 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913015101 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913015102 active site 1156913015103 catalytic tetrad [active] 1156913015104 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913015105 Cytochrome P450; Region: p450; cl12078 1156913015106 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015107 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015108 DNA binding residues [nucleotide binding] 1156913015109 dimerization interface [polypeptide binding]; other site 1156913015110 AAA-like domain; Region: AAA_10; pfam12846 1156913015111 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1156913015112 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1156913015113 NlpC/P60 family; Region: NLPC_P60; pfam00877 1156913015114 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913015115 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1156913015116 NAD(P) binding site [chemical binding]; other site 1156913015117 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1156913015118 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1156913015119 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1156913015120 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1156913015121 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1156913015122 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1156913015123 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1156913015124 Protein of unknown function (DUF690); Region: DUF690; cl04939 1156913015125 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1156913015126 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1156913015127 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015128 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015129 dimerization interface [polypeptide binding]; other site 1156913015130 DNA binding residues [nucleotide binding] 1156913015131 salicylate synthase MbtI; Reviewed; Region: PRK07912 1156913015132 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1156913015133 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 1156913015134 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1156913015135 DNA-binding site [nucleotide binding]; DNA binding site 1156913015136 RNA-binding motif; other site 1156913015137 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015138 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015139 DNA binding residues [nucleotide binding] 1156913015140 dimerization interface [polypeptide binding]; other site 1156913015141 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1156913015142 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1156913015143 putative NAD(P) binding site [chemical binding]; other site 1156913015144 active site 1156913015145 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913015146 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913015147 active site 1156913015148 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1156913015149 active site 1156913015150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913015151 NAD(P) binding site [chemical binding]; other site 1156913015152 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1156913015153 active site 1156913015154 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1156913015155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015157 DNA binding residues [nucleotide binding] 1156913015158 dimerization interface [polypeptide binding]; other site 1156913015159 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1156913015160 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913015161 acyl-activating enzyme (AAE) consensus motif; other site 1156913015162 AMP binding site [chemical binding]; other site 1156913015163 active site 1156913015164 CoA binding site [chemical binding]; other site 1156913015165 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1156913015166 classical (c) SDRs; Region: SDR_c; cd05233 1156913015167 NAD(P) binding site [chemical binding]; other site 1156913015168 active site 1156913015169 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1156913015170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913015171 S-adenosylmethionine binding site [chemical binding]; other site 1156913015172 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1156913015173 active sites [active] 1156913015174 tetramer interface [polypeptide binding]; other site 1156913015175 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1156913015176 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1156913015177 active site 1156913015178 NAD binding site [chemical binding]; other site 1156913015179 metal binding site [ion binding]; metal-binding site 1156913015180 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1156913015181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913015182 NAD(P) binding site [chemical binding]; other site 1156913015183 active site 1156913015184 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1156913015185 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1156913015186 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1156913015187 active site 1156913015188 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1156913015189 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1156913015190 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1156913015191 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913015192 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1156913015193 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913015194 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913015195 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1156913015196 active site 1156913015197 catalytic residues [active] 1156913015198 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 1156913015199 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1156913015200 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1156913015201 Right handed beta helix region; Region: Beta_helix; pfam13229 1156913015202 Right handed beta helix region; Region: Beta_helix; pfam13229 1156913015203 Right handed beta helix region; Region: Beta_helix; pfam13229 1156913015204 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1156913015205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913015206 Walker A motif; other site 1156913015207 ATP binding site [chemical binding]; other site 1156913015208 Walker B motif; other site 1156913015209 arginine finger; other site 1156913015210 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015212 DNA binding residues [nucleotide binding] 1156913015213 dimerization interface [polypeptide binding]; other site 1156913015214 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 1156913015215 AAA ATPase domain; Region: AAA_16; pfam13191 1156913015216 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015218 DNA binding residues [nucleotide binding] 1156913015219 dimerization interface [polypeptide binding]; other site 1156913015220 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1156913015221 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015222 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015223 DNA binding residues [nucleotide binding] 1156913015224 dimerization interface [polypeptide binding]; other site 1156913015225 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015227 DNA binding residues [nucleotide binding] 1156913015228 dimerization interface [polypeptide binding]; other site 1156913015229 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913015230 DNA binding site [nucleotide binding] 1156913015231 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913015232 AAA ATPase domain; Region: AAA_16; pfam13191 1156913015233 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913015234 DNA binding site [nucleotide binding] 1156913015235 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913015236 Predicted ATPase [General function prediction only]; Region: COG3899 1156913015237 AAA ATPase domain; Region: AAA_16; pfam13191 1156913015238 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015239 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015240 DNA binding residues [nucleotide binding] 1156913015241 dimerization interface [polypeptide binding]; other site 1156913015242 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1156913015243 beta-galactosidase; Region: BGL; TIGR03356 1156913015244 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1156913015245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913015246 dimer interface [polypeptide binding]; other site 1156913015247 conserved gate region; other site 1156913015248 putative PBP binding loops; other site 1156913015249 ABC-ATPase subunit interface; other site 1156913015250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913015251 dimer interface [polypeptide binding]; other site 1156913015252 conserved gate region; other site 1156913015253 putative PBP binding loops; other site 1156913015254 ABC-ATPase subunit interface; other site 1156913015255 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1156913015256 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1156913015257 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015258 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015259 DNA binding residues [nucleotide binding] 1156913015260 dimerization interface [polypeptide binding]; other site 1156913015261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913015262 DNA-binding site [nucleotide binding]; DNA binding site 1156913015263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913015264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913015265 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1156913015266 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913015267 NAD(P) binding site [chemical binding]; other site 1156913015268 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1156913015269 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1156913015270 Beta/Gamma crystallin; Region: Crystall; cl02528 1156913015271 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 1156913015272 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913015273 NB-ARC domain; Region: NB-ARC; pfam00931 1156913015274 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913015275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913015276 binding surface 1156913015277 TPR motif; other site 1156913015278 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913015279 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913015280 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1156913015281 benzoate transport; Region: 2A0115; TIGR00895 1156913015282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913015283 putative substrate translocation pore; other site 1156913015284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913015285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913015286 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913015287 active site 1156913015288 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913015289 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1156913015290 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913015291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913015292 catalytic residue [active] 1156913015293 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1156913015294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913015295 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913015296 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913015297 catalytic residue [active] 1156913015298 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1156913015299 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 1156913015300 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913015301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913015302 S-adenosylmethionine binding site [chemical binding]; other site 1156913015303 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913015304 NAD(P) binding site [chemical binding]; other site 1156913015305 catalytic residues [active] 1156913015306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913015307 active site 1156913015308 AMP binding site [chemical binding]; other site 1156913015309 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1156913015310 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1156913015311 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1156913015312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913015313 NAD(P) binding site [chemical binding]; other site 1156913015314 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1156913015315 active site 1156913015316 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1156913015317 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1156913015318 active site 1156913015319 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1156913015320 active site 1156913015321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913015322 NAD(P) binding site [chemical binding]; other site 1156913015323 active site 1156913015324 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1156913015325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913015326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913015327 NAD(P) binding site [chemical binding]; other site 1156913015328 active site 1156913015329 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1156913015330 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913015331 Cytochrome P450; Region: p450; cl12078 1156913015332 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1156913015333 acyl-CoA synthetase; Validated; Region: PRK05850 1156913015334 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1156913015335 acyl-activating enzyme (AAE) consensus motif; other site 1156913015336 active site 1156913015337 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913015338 Cytochrome P450; Region: p450; cl12078 1156913015339 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1156913015340 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1156913015341 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1156913015342 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1156913015343 D-pathway; other site 1156913015344 Putative ubiquinol binding site [chemical binding]; other site 1156913015345 Low-spin heme (heme b) binding site [chemical binding]; other site 1156913015346 Putative water exit pathway; other site 1156913015347 Binuclear center (heme o3/CuB) [ion binding]; other site 1156913015348 K-pathway; other site 1156913015349 Putative proton exit pathway; other site 1156913015350 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 1156913015351 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1156913015352 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1156913015353 putative dimer interface [polypeptide binding]; other site 1156913015354 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1156913015355 HSP70 interaction site [polypeptide binding]; other site 1156913015356 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1156913015357 active site 1156913015358 DNA binding site [nucleotide binding] 1156913015359 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 1156913015360 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1156913015361 DNA binding site [nucleotide binding] 1156913015362 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1156913015363 nucleotide binding site [chemical binding]; other site 1156913015364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913015365 NAD(P) binding site [chemical binding]; other site 1156913015366 active site 1156913015367 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913015368 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913015369 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1156913015370 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1156913015371 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1156913015372 dimer interface [polypeptide binding]; other site 1156913015373 active site 1156913015374 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913015376 active site 1156913015377 phosphorylation site [posttranslational modification] 1156913015378 intermolecular recognition site; other site 1156913015379 dimerization interface [polypeptide binding]; other site 1156913015380 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015381 DNA binding residues [nucleotide binding] 1156913015382 dimerization interface [polypeptide binding]; other site 1156913015383 Histidine kinase; Region: HisKA_3; pfam07730 1156913015384 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913015385 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913015386 Asp23 family; Region: Asp23; pfam03780 1156913015387 Asp23 family; Region: Asp23; pfam03780 1156913015388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913015389 NAD(P) binding site [chemical binding]; other site 1156913015390 active site 1156913015391 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1156913015392 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1156913015393 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913015394 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913015395 DNA binding residues [nucleotide binding] 1156913015396 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913015397 MarR family; Region: MarR_2; pfam12802 1156913015398 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913015399 Cytochrome P450; Region: p450; cl12078 1156913015400 CsbD-like; Region: CsbD; cl17424 1156913015401 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913015402 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1156913015403 B3/4 domain; Region: B3_4; pfam03483 1156913015404 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1156913015405 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1156913015406 putative DNA binding site [nucleotide binding]; other site 1156913015407 putative homodimer interface [polypeptide binding]; other site 1156913015408 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913015409 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913015410 NACHT domain; Region: NACHT; pfam05729 1156913015411 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913015412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1156913015413 binding surface 1156913015414 TPR motif; other site 1156913015415 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913015416 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1156913015417 putative FMN binding site [chemical binding]; other site 1156913015418 NADPH bind site [chemical binding]; other site 1156913015419 hypothetical protein; Provisional; Region: PRK08317 1156913015420 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1156913015421 S-adenosylmethionine binding site [chemical binding]; other site 1156913015422 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1156913015423 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913015424 DNA binding residues [nucleotide binding] 1156913015425 dimer interface [polypeptide binding]; other site 1156913015426 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1156913015427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913015428 dimerization interface [polypeptide binding]; other site 1156913015429 putative DNA binding site [nucleotide binding]; other site 1156913015430 putative Zn2+ binding site [ion binding]; other site 1156913015431 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1156913015432 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1156913015433 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1156913015434 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1156913015435 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913015436 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1156913015437 nudix motif; other site 1156913015438 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1156913015439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913015440 DNA-binding site [nucleotide binding]; DNA binding site 1156913015441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913015442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913015443 homodimer interface [polypeptide binding]; other site 1156913015444 catalytic residue [active] 1156913015445 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1156913015446 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1156913015447 dimer interface [polypeptide binding]; other site 1156913015448 ssDNA binding site [nucleotide binding]; other site 1156913015449 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1156913015450 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1156913015451 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1156913015452 substrate binding pocket [chemical binding]; other site 1156913015453 chain length determination region; other site 1156913015454 substrate-Mg2+ binding site; other site 1156913015455 catalytic residues [active] 1156913015456 aspartate-rich region 1; other site 1156913015457 active site lid residues [active] 1156913015458 aspartate-rich region 2; other site 1156913015459 Cupin domain; Region: Cupin_2; pfam07883 1156913015460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913015461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913015462 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1156913015463 DinB superfamily; Region: DinB_2; pfam12867 1156913015464 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1156913015465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913015466 dimerization interface [polypeptide binding]; other site 1156913015467 putative DNA binding site [nucleotide binding]; other site 1156913015468 putative Zn2+ binding site [ion binding]; other site 1156913015469 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1156913015470 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913015471 ATP binding site [chemical binding]; other site 1156913015472 putative Mg++ binding site [ion binding]; other site 1156913015473 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913015474 nucleotide binding region [chemical binding]; other site 1156913015475 ATP-binding site [chemical binding]; other site 1156913015476 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1156913015477 HRDC domain; Region: HRDC; pfam00570 1156913015478 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1156913015479 adenosine deaminase; Provisional; Region: PRK09358 1156913015480 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1156913015481 active site 1156913015482 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 1156913015483 Ca binding site [ion binding]; other site 1156913015484 Ca binding site (active) [ion binding]; other site 1156913015485 ligand binding site [chemical binding]; other site 1156913015486 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1156913015487 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1156913015488 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1156913015489 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1156913015490 metal ion-dependent adhesion site (MIDAS); other site 1156913015491 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1156913015492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913015493 Walker A motif; other site 1156913015494 ATP binding site [chemical binding]; other site 1156913015495 Walker B motif; other site 1156913015496 arginine finger; other site 1156913015497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913015498 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913015499 putative substrate translocation pore; other site 1156913015500 Predicted transcriptional regulator [Transcription]; Region: COG2378 1156913015501 HTH domain; Region: HTH_11; pfam08279 1156913015502 WYL domain; Region: WYL; pfam13280 1156913015503 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913015504 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913015505 active site 1156913015506 catalytic tetrad [active] 1156913015507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913015508 S-adenosylmethionine binding site [chemical binding]; other site 1156913015509 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913015510 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913015511 active site 1156913015512 catalytic tetrad [active] 1156913015513 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913015514 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1156913015515 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913015516 catalytic loop [active] 1156913015517 iron binding site [ion binding]; other site 1156913015518 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1156913015519 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1156913015520 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1156913015521 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1156913015522 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1156913015523 RNA polymerase sigma factor; Provisional; Region: PRK12535 1156913015524 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913015525 DNA binding residues [nucleotide binding] 1156913015526 Predicted integral membrane protein [Function unknown]; Region: COG5660 1156913015527 Putative zinc-finger; Region: zf-HC2; pfam13490 1156913015528 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913015529 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1156913015530 nucleotide binding site [chemical binding]; other site 1156913015531 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913015532 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1156913015533 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1156913015534 CoenzymeA binding site [chemical binding]; other site 1156913015535 subunit interaction site [polypeptide binding]; other site 1156913015536 PHB binding site; other site 1156913015537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913015538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913015539 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1156913015540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913015541 motif II; other site 1156913015542 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1156913015543 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1156913015544 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1156913015545 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1156913015546 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1156913015547 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1156913015548 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1156913015549 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913015550 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1156913015551 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1156913015552 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1156913015553 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1156913015554 active site 1156913015555 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1156913015556 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1156913015557 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913015558 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913015559 catalytic residue [active] 1156913015560 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1156913015561 Peptidase family M23; Region: Peptidase_M23; pfam01551 1156913015562 potassium/proton antiporter; Reviewed; Region: PRK05326 1156913015563 TrkA-C domain; Region: TrkA_C; pfam02080 1156913015564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1156913015565 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1156913015566 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1156913015567 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1156913015568 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1156913015569 HIGH motif; other site 1156913015570 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1156913015571 active site 1156913015572 KMSKS motif; other site 1156913015573 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1156913015574 tRNA binding surface [nucleotide binding]; other site 1156913015575 anticodon binding site; other site 1156913015576 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913015577 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913015578 active site 1156913015579 DivIVA domain; Region: DivI1A_domain; TIGR03544 1156913015580 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1156913015581 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1156913015582 Predicted integral membrane protein [Function unknown]; Region: COG0762 1156913015583 Protein of unknown function (DUF552); Region: DUF552; cl00775 1156913015584 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1156913015585 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1156913015586 catalytic residue [active] 1156913015587 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1156913015588 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1156913015589 cell division protein FtsZ; Validated; Region: PRK09330 1156913015590 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1156913015591 nucleotide binding site [chemical binding]; other site 1156913015592 SulA interaction site; other site 1156913015593 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1156913015594 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1156913015595 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1156913015596 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913015597 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913015598 DNA binding residues [nucleotide binding] 1156913015599 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1156913015600 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1156913015601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913015602 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913015603 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1156913015604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913015605 S-adenosylmethionine binding site [chemical binding]; other site 1156913015606 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1156913015607 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1156913015608 DinB superfamily; Region: DinB_2; pfam12867 1156913015609 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1156913015610 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1156913015611 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1156913015612 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1156913015613 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913015614 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1156913015615 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913015616 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 1156913015617 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1156913015618 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1156913015619 active site 1156913015620 dimer interface [polypeptide binding]; other site 1156913015621 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1156913015622 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1156913015623 active site 1156913015624 FMN binding site [chemical binding]; other site 1156913015625 substrate binding site [chemical binding]; other site 1156913015626 3Fe-4S cluster binding site [ion binding]; other site 1156913015627 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1156913015628 domain interface; other site 1156913015629 short chain dehydrogenase; Provisional; Region: PRK07814 1156913015630 classical (c) SDRs; Region: SDR_c; cd05233 1156913015631 NAD(P) binding site [chemical binding]; other site 1156913015632 active site 1156913015633 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1156913015634 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1156913015635 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1156913015636 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1156913015637 metal binding site [ion binding]; metal-binding site 1156913015638 dimer interface [polypeptide binding]; other site 1156913015639 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913015640 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1156913015641 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1156913015642 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1156913015643 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1156913015644 substrate binding site [chemical binding]; other site 1156913015645 active site 1156913015646 catalytic residues [active] 1156913015647 heterodimer interface [polypeptide binding]; other site 1156913015648 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1156913015649 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1156913015650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913015651 catalytic residue [active] 1156913015652 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1156913015653 active site 1156913015654 ribulose/triose binding site [chemical binding]; other site 1156913015655 phosphate binding site [ion binding]; other site 1156913015656 substrate (anthranilate) binding pocket [chemical binding]; other site 1156913015657 product (indole) binding pocket [chemical binding]; other site 1156913015658 anthranilate synthase component I; Provisional; Region: PRK13571 1156913015659 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1156913015660 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1156913015661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913015662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913015663 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1156913015664 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1156913015665 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1156913015666 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1156913015667 substrate binding site [chemical binding]; other site 1156913015668 glutamase interaction surface [polypeptide binding]; other site 1156913015669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913015670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913015671 Phytase; Region: Phytase; cl17685 1156913015672 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1156913015673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913015674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913015675 DNA binding residues [nucleotide binding] 1156913015676 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913015677 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1156913015678 putative NAD(P) binding site [chemical binding]; other site 1156913015679 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1156913015680 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913015681 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1156913015682 Walker A/P-loop; other site 1156913015683 ATP binding site [chemical binding]; other site 1156913015684 Q-loop/lid; other site 1156913015685 ABC transporter signature motif; other site 1156913015686 Walker B; other site 1156913015687 D-loop; other site 1156913015688 H-loop/switch region; other site 1156913015689 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1156913015690 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1156913015691 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1156913015692 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1156913015693 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1156913015694 catalytic residues [active] 1156913015695 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1156913015696 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1156913015697 putative active site [active] 1156913015698 oxyanion strand; other site 1156913015699 catalytic triad [active] 1156913015700 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913015701 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913015702 active site 1156913015703 NIPSNAP; Region: NIPSNAP; pfam07978 1156913015704 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1156913015705 nudix motif; other site 1156913015706 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1156913015707 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1156913015708 PYR/PP interface [polypeptide binding]; other site 1156913015709 dimer interface [polypeptide binding]; other site 1156913015710 TPP binding site [chemical binding]; other site 1156913015711 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1156913015712 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1156913015713 TPP-binding site [chemical binding]; other site 1156913015714 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1156913015715 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1156913015716 DNA binding residues [nucleotide binding] 1156913015717 dimer interface [polypeptide binding]; other site 1156913015718 [2Fe-2S] cluster binding site [ion binding]; other site 1156913015719 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1156913015720 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1156913015721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913015722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913015723 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1156913015724 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1156913015725 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913015726 dimerization interface [polypeptide binding]; other site 1156913015727 putative DNA binding site [nucleotide binding]; other site 1156913015728 putative Zn2+ binding site [ion binding]; other site 1156913015729 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1156913015730 putative hydrophobic ligand binding site [chemical binding]; other site 1156913015731 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1156913015732 RibD C-terminal domain; Region: RibD_C; cl17279 1156913015733 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1156913015734 putative active site pocket [active] 1156913015735 4-fold oligomerization interface [polypeptide binding]; other site 1156913015736 metal binding residues [ion binding]; metal-binding site 1156913015737 3-fold/trimer interface [polypeptide binding]; other site 1156913015738 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1156913015739 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913015740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913015741 homodimer interface [polypeptide binding]; other site 1156913015742 catalytic residue [active] 1156913015743 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1156913015744 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1156913015745 NAD binding site [chemical binding]; other site 1156913015746 dimerization interface [polypeptide binding]; other site 1156913015747 product binding site; other site 1156913015748 substrate binding site [chemical binding]; other site 1156913015749 zinc binding site [ion binding]; other site 1156913015750 catalytic residues [active] 1156913015751 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1156913015752 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1156913015753 putative active site [active] 1156913015754 catalytic triad [active] 1156913015755 putative dimer interface [polypeptide binding]; other site 1156913015756 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1156913015757 Strictosidine synthase; Region: Str_synth; pfam03088 1156913015758 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913015760 active site 1156913015761 phosphorylation site [posttranslational modification] 1156913015762 intermolecular recognition site; other site 1156913015763 dimerization interface [polypeptide binding]; other site 1156913015764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015765 DNA binding residues [nucleotide binding] 1156913015766 dimerization interface [polypeptide binding]; other site 1156913015767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913015768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913015769 active site 1156913015770 phosphorylation site [posttranslational modification] 1156913015771 intermolecular recognition site; other site 1156913015772 dimerization interface [polypeptide binding]; other site 1156913015773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913015774 DNA binding residues [nucleotide binding] 1156913015775 dimerization interface [polypeptide binding]; other site 1156913015776 Protein of unknown function (DUF690); Region: DUF690; cl04939 1156913015777 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 1156913015778 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1156913015779 hypothetical protein; Validated; Region: PRK00153 1156913015780 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1156913015781 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1156913015782 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913015783 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1156913015784 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913015785 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913015786 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913015787 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913015788 active site 1156913015789 Chloramphenicol phosphotransferase-like protein; Region: CPT; pfam07931 1156913015790 P-loop motif; other site 1156913015791 ATP binding site [chemical binding]; other site 1156913015792 Chloramphenicol (Cm) binding site [chemical binding]; other site 1156913015793 catalytic residue [active] 1156913015794 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913015795 cleavage site 1156913015796 active site 1156913015797 substrate binding sites [chemical binding]; other site 1156913015798 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1156913015799 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1156913015800 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1156913015801 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1156913015802 active site 1156913015803 catalytic residues [active] 1156913015804 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1156913015805 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1156913015806 dimerization interface [polypeptide binding]; other site 1156913015807 active site 1156913015808 L-aspartate oxidase; Provisional; Region: PRK07804 1156913015809 L-aspartate oxidase; Provisional; Region: PRK06175 1156913015810 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1156913015811 quinolinate synthetase; Provisional; Region: PRK09375 1156913015812 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1156913015813 nudix motif; other site 1156913015814 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1156913015815 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1156913015816 Peptidase family M48; Region: Peptidase_M48; cl12018 1156913015817 biotin synthase; Validated; Region: PRK06256 1156913015818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913015819 FeS/SAM binding site; other site 1156913015820 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1156913015821 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1156913015822 AAA domain; Region: AAA_26; pfam13500 1156913015823 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1156913015824 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1156913015825 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1156913015826 active site clefts [active] 1156913015827 zinc binding site [ion binding]; other site 1156913015828 dimer interface [polypeptide binding]; other site 1156913015829 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1156913015830 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1156913015831 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1156913015832 active site clefts [active] 1156913015833 zinc binding site [ion binding]; other site 1156913015834 dimer interface [polypeptide binding]; other site 1156913015835 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913015836 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1156913015837 inhibitor-cofactor binding pocket; inhibition site 1156913015838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913015839 catalytic residue [active] 1156913015840 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913015841 Cytochrome P450; Region: p450; cl12078 1156913015842 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1156913015843 hydrophobic ligand binding site; other site 1156913015844 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1156913015845 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913015846 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1156913015847 NlpC/P60 family; Region: NLPC_P60; pfam00877 1156913015848 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1156913015849 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1156913015850 YacP-like NYN domain; Region: NYN_YacP; cl01491 1156913015851 hypothetical protein; Validated; Region: PRK07883 1156913015852 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1156913015853 active site 1156913015854 catalytic site [active] 1156913015855 substrate binding site [chemical binding]; other site 1156913015856 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1156913015857 GIY-YIG motif/motif A; other site 1156913015858 active site 1156913015859 catalytic site [active] 1156913015860 putative DNA binding site [nucleotide binding]; other site 1156913015861 metal binding site [ion binding]; metal-binding site 1156913015862 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913015863 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913015864 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1156913015865 LGFP repeat; Region: LGFP; pfam08310 1156913015866 LGFP repeat; Region: LGFP; pfam08310 1156913015867 LGFP repeat; Region: LGFP; pfam08310 1156913015868 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1156913015869 LGFP repeat; Region: LGFP; pfam08310 1156913015870 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 1156913015871 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1156913015872 heme bH binding site [chemical binding]; other site 1156913015873 Qi binding site; other site 1156913015874 intrachain domain interface; other site 1156913015875 heme bL binding site [chemical binding]; other site 1156913015876 interchain domain interface [polypeptide binding]; other site 1156913015877 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1156913015878 Qo binding site; other site 1156913015879 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 1156913015880 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1156913015881 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1156913015882 iron-sulfur cluster [ion binding]; other site 1156913015883 [2Fe-2S] cluster binding site [ion binding]; other site 1156913015884 Cytochrome c; Region: Cytochrom_C; cl11414 1156913015885 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1156913015886 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1156913015887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1156913015888 active site 1156913015889 phosphorylation site [posttranslational modification] 1156913015890 intermolecular recognition site; other site 1156913015891 dimerization interface [polypeptide binding]; other site 1156913015892 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1156913015893 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1156913015894 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1156913015895 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1156913015896 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913015897 conserved cys residue [active] 1156913015898 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913015899 Cupin domain; Region: Cupin_2; cl17218 1156913015900 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1156913015901 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913015902 conserved cys residue [active] 1156913015903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913015904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913015905 EamA-like transporter family; Region: EamA; pfam00892 1156913015906 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1156913015907 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1156913015908 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1156913015909 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1156913015910 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1156913015911 active site 1156913015912 dimer interface [polypeptide binding]; other site 1156913015913 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1156913015914 Ligand Binding Site [chemical binding]; other site 1156913015915 Molecular Tunnel; other site 1156913015916 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913015917 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1156913015918 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1156913015919 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1156913015920 substrate binding site [chemical binding]; other site 1156913015921 ATP binding site [chemical binding]; other site 1156913015922 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1156913015923 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1156913015924 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913015925 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913015926 active site 1156913015927 catalytic tetrad [active] 1156913015928 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1156913015929 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1156913015930 ATP binding site [chemical binding]; other site 1156913015931 active site 1156913015932 substrate binding site [chemical binding]; other site 1156913015933 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1156913015934 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913015935 DNA-binding site [nucleotide binding]; DNA binding site 1156913015936 UTRA domain; Region: UTRA; cl17743 1156913015937 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1156913015938 substrate binding site; other site 1156913015939 dimer interface; other site 1156913015940 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1156913015941 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1156913015942 putative dimer interface [polypeptide binding]; other site 1156913015943 active site pocket [active] 1156913015944 putative cataytic base [active] 1156913015945 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1156913015946 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1156913015947 homodimer interface [polypeptide binding]; other site 1156913015948 substrate-cofactor binding pocket; other site 1156913015949 catalytic residue [active] 1156913015950 Protein of unknown function (DUF402); Region: DUF402; pfam04167 1156913015951 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1156913015952 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1156913015953 interface (dimer of trimers) [polypeptide binding]; other site 1156913015954 Substrate-binding/catalytic site; other site 1156913015955 Zn-binding sites [ion binding]; other site 1156913015956 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1156913015957 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1156913015958 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913015959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913015960 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1156913015961 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1156913015962 E3 interaction surface; other site 1156913015963 lipoyl attachment site [posttranslational modification]; other site 1156913015964 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1156913015965 E3 interaction surface; other site 1156913015966 lipoyl attachment site [posttranslational modification]; other site 1156913015967 e3 binding domain; Region: E3_binding; pfam02817 1156913015968 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1156913015969 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1156913015970 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1156913015971 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913015972 dimerization interface [polypeptide binding]; other site 1156913015973 putative DNA binding site [nucleotide binding]; other site 1156913015974 putative Zn2+ binding site [ion binding]; other site 1156913015975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913015976 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1156913015977 NAD(P) binding site [chemical binding]; other site 1156913015978 active site 1156913015979 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1156913015980 active site 1156913015981 lipoate-protein ligase B; Provisional; Region: PRK14345 1156913015982 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1156913015983 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913015984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913015985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913015986 short chain dehydrogenase; Provisional; Region: PRK06197 1156913015987 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1156913015988 putative NAD(P) binding site [chemical binding]; other site 1156913015989 active site 1156913015990 lipoyl synthase; Provisional; Region: PRK05481 1156913015991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913015992 FeS/SAM binding site; other site 1156913015993 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1156913015994 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1156913015995 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1156913015996 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1156913015997 nucleophile elbow; other site 1156913015998 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1156913015999 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1156913016000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1156913016001 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1156913016002 NAD-dependent deacetylase; Provisional; Region: PRK00481 1156913016003 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1156913016004 NAD+ binding site [chemical binding]; other site 1156913016005 substrate binding site [chemical binding]; other site 1156913016006 Zn binding site [ion binding]; other site 1156913016007 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1156913016008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913016009 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913016010 putative substrate translocation pore; other site 1156913016011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913016012 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1156913016013 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1156913016014 active site 1156913016015 PHP Thumb interface [polypeptide binding]; other site 1156913016016 metal binding site [ion binding]; metal-binding site 1156913016017 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1156913016018 generic binding surface II; other site 1156913016019 generic binding surface I; other site 1156913016020 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1156913016021 Domain of unknown function (DUF385); Region: DUF385; cl04387 1156913016022 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1156913016023 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1156913016024 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1156913016025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913016026 DNA-binding site [nucleotide binding]; DNA binding site 1156913016027 FCD domain; Region: FCD; pfam07729 1156913016028 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1156913016029 L-asparaginase II; Region: Asparaginase_II; pfam06089 1156913016030 Aspartase; Region: Aspartase; cd01357 1156913016031 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1156913016032 active sites [active] 1156913016033 tetramer interface [polypeptide binding]; other site 1156913016034 Predicted acyl esterases [General function prediction only]; Region: COG2936 1156913016035 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1156913016036 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1156913016037 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913016038 active site 1156913016039 metal binding site [ion binding]; metal-binding site 1156913016040 hexamer interface [polypeptide binding]; other site 1156913016041 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1156913016042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913016043 DNA-binding site [nucleotide binding]; DNA binding site 1156913016044 FCD domain; Region: FCD; pfam07729 1156913016045 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1156913016046 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913016047 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913016048 catalytic residue [active] 1156913016049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913016050 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1156913016051 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1156913016052 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913016053 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1156913016054 acyl-activating enzyme (AAE) consensus motif; other site 1156913016055 acyl-activating enzyme (AAE) consensus motif; other site 1156913016056 putative AMP binding site [chemical binding]; other site 1156913016057 putative active site [active] 1156913016058 putative CoA binding site [chemical binding]; other site 1156913016059 Cupin domain; Region: Cupin_2; pfam07883 1156913016060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913016061 putative DNA binding site [nucleotide binding]; other site 1156913016062 putative Zn2+ binding site [ion binding]; other site 1156913016063 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1156913016064 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1156913016065 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1156913016066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913016067 Coenzyme A binding pocket [chemical binding]; other site 1156913016068 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1156913016069 dimer interface [polypeptide binding]; other site 1156913016070 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1156913016071 catalytic triad [active] 1156913016072 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1156913016073 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1156913016074 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1156913016075 dimer interface [polypeptide binding]; other site 1156913016076 TPP-binding site [chemical binding]; other site 1156913016077 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1156913016078 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1156913016079 phosphate binding site [ion binding]; other site 1156913016080 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1156913016081 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913016082 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1156913016083 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1156913016084 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1156913016085 dimer interface [polypeptide binding]; other site 1156913016086 active site 1156913016087 CoA binding pocket [chemical binding]; other site 1156913016088 acyl carrier protein; Provisional; Region: acpP; PRK00982 1156913016089 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1156913016090 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1156913016091 dimer interface [polypeptide binding]; other site 1156913016092 active site 1156913016093 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1156913016094 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1156913016095 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1156913016096 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1156913016097 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1156913016098 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1156913016099 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1156913016100 active site 1156913016101 catalytic residues [active] 1156913016102 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1156913016103 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913016104 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1156913016105 Lsr2; Region: Lsr2; pfam11774 1156913016106 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1156913016107 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1156913016108 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1156913016109 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1156913016110 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1156913016111 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1156913016112 ligand binding site [chemical binding]; other site 1156913016113 homodimer interface [polypeptide binding]; other site 1156913016114 NAD(P) binding site [chemical binding]; other site 1156913016115 trimer interface B [polypeptide binding]; other site 1156913016116 trimer interface A [polypeptide binding]; other site 1156913016117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913016118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913016119 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1156913016120 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1156913016121 FAD binding pocket [chemical binding]; other site 1156913016122 FAD binding motif [chemical binding]; other site 1156913016123 phosphate binding motif [ion binding]; other site 1156913016124 beta-alpha-beta structure motif; other site 1156913016125 NAD binding pocket [chemical binding]; other site 1156913016126 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913016127 catalytic loop [active] 1156913016128 iron binding site [ion binding]; other site 1156913016129 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1156913016130 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1156913016131 putative di-iron ligands [ion binding]; other site 1156913016132 Putative sensor; Region: Sensor; pfam13796 1156913016133 Histidine kinase; Region: HisKA_3; pfam07730 1156913016134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913016135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913016136 active site 1156913016137 phosphorylation site [posttranslational modification] 1156913016138 intermolecular recognition site; other site 1156913016139 dimerization interface [polypeptide binding]; other site 1156913016140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913016141 DNA binding residues [nucleotide binding] 1156913016142 AAA domain; Region: AAA_18; pfam13238 1156913016143 AAA domain; Region: AAA_17; pfam13207 1156913016144 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1156913016145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1156913016146 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913016147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913016148 sequence-specific DNA binding site [nucleotide binding]; other site 1156913016149 salt bridge; other site 1156913016150 Cupin domain; Region: Cupin_2; cl17218 1156913016151 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1156913016152 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1156913016153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913016154 motif II; other site 1156913016155 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1156913016156 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1156913016157 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1156913016158 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1156913016159 dimer interface [polypeptide binding]; other site 1156913016160 motif 1; other site 1156913016161 active site 1156913016162 motif 2; other site 1156913016163 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1156913016164 putative deacylase active site [active] 1156913016165 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1156913016166 active site 1156913016167 motif 3; other site 1156913016168 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1156913016169 anticodon binding site; other site 1156913016170 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913016171 active site 1156913016172 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 1156913016173 putative ligand binding site [chemical binding]; other site 1156913016174 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1156913016175 putative NAD binding site [chemical binding]; other site 1156913016176 catalytic site [active] 1156913016177 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1156913016178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1156913016179 hypothetical protein; Validated; Region: PRK02101 1156913016180 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913016181 active site 1156913016182 substrate binding sites [chemical binding]; other site 1156913016183 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1156913016184 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1156913016185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913016186 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1156913016187 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1156913016188 calcium binding site 2 [ion binding]; other site 1156913016189 active site 1156913016190 catalytic triad [active] 1156913016191 calcium binding site 1 [ion binding]; other site 1156913016192 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1156913016193 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1156913016194 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1156913016195 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1156913016196 calcium binding site 2 [ion binding]; other site 1156913016197 active site 1156913016198 catalytic triad [active] 1156913016199 calcium binding site 1 [ion binding]; other site 1156913016200 AAA ATPase domain; Region: AAA_16; pfam13191 1156913016201 Walker A motif; other site 1156913016202 ATP binding site [chemical binding]; other site 1156913016203 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913016204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913016205 DNA binding residues [nucleotide binding] 1156913016206 dimerization interface [polypeptide binding]; other site 1156913016207 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 1156913016208 ATP binding site [chemical binding]; other site 1156913016209 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1156913016210 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1156913016211 ATP binding site [chemical binding]; other site 1156913016212 Mg++ binding site [ion binding]; other site 1156913016213 motif III; other site 1156913016214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913016215 nucleotide binding region [chemical binding]; other site 1156913016216 ATP-binding site [chemical binding]; other site 1156913016217 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1156913016218 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1156913016219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913016220 catalytic residue [active] 1156913016221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1156913016222 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1156913016223 cleavage site 1156913016224 active site 1156913016225 substrate binding sites [chemical binding]; other site 1156913016226 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1156913016227 mycothione reductase; Reviewed; Region: PRK07846 1156913016228 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913016229 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913016230 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1156913016231 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1156913016232 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1156913016233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913016234 DNA-binding site [nucleotide binding]; DNA binding site 1156913016235 FCD domain; Region: FCD; pfam07729 1156913016236 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1156913016237 active site 1156913016238 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1156913016239 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1156913016240 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1156913016241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1156913016242 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1156913016243 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1156913016244 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1156913016245 RIP metalloprotease RseP; Region: TIGR00054 1156913016246 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1156913016247 active site 1156913016248 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1156913016249 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1156913016250 putative substrate binding region [chemical binding]; other site 1156913016251 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1156913016252 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1156913016253 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1156913016254 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1156913016255 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1156913016256 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1156913016257 active site 1156913016258 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1156913016259 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1156913016260 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1156913016261 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1156913016262 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1156913016263 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1156913016264 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1156913016265 substrate binding pocket [chemical binding]; other site 1156913016266 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1156913016267 B12 binding site [chemical binding]; other site 1156913016268 cobalt ligand [ion binding]; other site 1156913016269 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1156913016270 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1156913016271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913016272 DNA-binding site [nucleotide binding]; DNA binding site 1156913016273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913016274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913016275 homodimer interface [polypeptide binding]; other site 1156913016276 catalytic residue [active] 1156913016277 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913016278 Cytochrome P450; Region: p450; cl12078 1156913016279 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913016280 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913016281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913016282 MarR family; Region: MarR_2; pfam12802 1156913016283 MarR family; Region: MarR_2; cl17246 1156913016284 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1156913016285 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913016286 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913016287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913016288 non-specific DNA binding site [nucleotide binding]; other site 1156913016289 salt bridge; other site 1156913016290 sequence-specific DNA binding site [nucleotide binding]; other site 1156913016291 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913016292 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1156913016293 putative NAD(P) binding site [chemical binding]; other site 1156913016294 PhoD-like phosphatase; Region: PhoD; pfam09423 1156913016295 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1156913016296 putative active site [active] 1156913016297 putative metal binding site [ion binding]; other site 1156913016298 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913016299 ANTAR domain; Region: ANTAR; pfam03861 1156913016300 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1156913016301 Isochorismatase family; Region: Isochorismatase; pfam00857 1156913016302 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1156913016303 catalytic triad [active] 1156913016304 conserved cis-peptide bond; other site 1156913016305 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913016306 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1156913016307 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913016308 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913016309 catalytic residue [active] 1156913016310 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1156913016311 Asp-box motif; other site 1156913016312 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1156913016313 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1156913016314 Helix-turn-helix domain; Region: HTH_18; pfam12833 1156913016315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913016316 RibD C-terminal domain; Region: RibD_C; cl17279 1156913016317 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1156913016318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913016319 FeS/SAM binding site; other site 1156913016320 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913016321 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1156913016322 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913016323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913016324 S-adenosylmethionine binding site [chemical binding]; other site 1156913016325 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1156913016326 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1156913016327 Carboxylesterase family; Region: COesterase; pfam00135 1156913016328 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1156913016329 substrate binding pocket [chemical binding]; other site 1156913016330 catalytic triad [active] 1156913016331 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1156913016332 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1156913016333 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1156913016334 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1156913016335 hinge region; other site 1156913016336 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1156913016337 putative nucleotide binding site [chemical binding]; other site 1156913016338 uridine monophosphate binding site [chemical binding]; other site 1156913016339 homohexameric interface [polypeptide binding]; other site 1156913016340 elongation factor Ts; Provisional; Region: tsf; PRK09377 1156913016341 UBA/TS-N domain; Region: UBA; pfam00627 1156913016342 Elongation factor TS; Region: EF_TS; pfam00889 1156913016343 Elongation factor TS; Region: EF_TS; pfam00889 1156913016344 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1156913016345 rRNA interaction site [nucleotide binding]; other site 1156913016346 S8 interaction site; other site 1156913016347 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1156913016348 Peptidase family M23; Region: Peptidase_M23; pfam01551 1156913016349 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 1156913016350 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913016351 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1156913016352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913016353 DNA binding residues [nucleotide binding] 1156913016354 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1156913016355 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1156913016356 active site 1156913016357 DNA binding site [nucleotide binding] 1156913016358 Int/Topo IB signature motif; other site 1156913016359 DNA protecting protein DprA; Region: dprA; TIGR00732 1156913016360 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1156913016361 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1156913016362 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1156913016363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913016364 Walker A motif; other site 1156913016365 ATP binding site [chemical binding]; other site 1156913016366 Walker B motif; other site 1156913016367 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1156913016368 hypothetical protein; Reviewed; Region: PRK12497 1156913016369 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1156913016370 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1156913016371 RNA/DNA hybrid binding site [nucleotide binding]; other site 1156913016372 active site 1156913016373 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1156913016374 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1156913016375 Catalytic site [active] 1156913016376 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1156913016377 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1156913016378 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1156913016379 RimM N-terminal domain; Region: RimM; pfam01782 1156913016380 PRC-barrel domain; Region: PRC; pfam05239 1156913016381 hypothetical protein; Provisional; Region: PRK02821 1156913016382 G-X-X-G motif; other site 1156913016383 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1156913016384 CAAX protease self-immunity; Region: Abi; pfam02517 1156913016385 CAAX protease self-immunity; Region: Abi; pfam02517 1156913016386 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1156913016387 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1156913016388 active site 1156913016389 signal recognition particle protein; Provisional; Region: PRK10867 1156913016390 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1156913016391 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1156913016392 P loop; other site 1156913016393 GTP binding site [chemical binding]; other site 1156913016394 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1156913016395 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1156913016396 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1156913016397 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1156913016398 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1156913016399 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1156913016400 putative DNA binding site [nucleotide binding]; other site 1156913016401 putative homodimer interface [polypeptide binding]; other site 1156913016402 PII uridylyl-transferase; Provisional; Region: PRK03381 1156913016403 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1156913016404 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1156913016405 Zn2+ binding site [ion binding]; other site 1156913016406 Mg2+ binding site [ion binding]; other site 1156913016407 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1156913016408 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1156913016409 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1156913016410 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1156913016411 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1156913016412 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1156913016413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913016414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913016415 DNA binding residues [nucleotide binding] 1156913016416 dimerization interface [polypeptide binding]; other site 1156913016417 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1156913016418 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1156913016419 homodimer interface [polypeptide binding]; other site 1156913016420 substrate-cofactor binding pocket; other site 1156913016421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913016422 catalytic residue [active] 1156913016423 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1156913016424 allantoicase; Provisional; Region: PRK13257 1156913016425 Allantoicase repeat; Region: Allantoicase; pfam03561 1156913016426 Allantoicase repeat; Region: Allantoicase; pfam03561 1156913016427 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1156913016428 allantoinase; Region: allantoinase; TIGR03178 1156913016429 active site 1156913016430 Domain of unknown function DUF77; Region: DUF77; cl00307 1156913016431 HTH domain; Region: HTH_22; pfam13309 1156913016432 putative OHCU decarboxylase; Provisional; Region: PRK13798 1156913016433 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1156913016434 active site 1156913016435 homotetramer interface [polypeptide binding]; other site 1156913016436 urate oxidase; Region: urate_oxi; TIGR03383 1156913016437 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1156913016438 active site 1156913016439 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913016440 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913016441 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913016442 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913016443 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1156913016444 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1156913016445 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1156913016446 nucleoside/Zn binding site; other site 1156913016447 dimer interface [polypeptide binding]; other site 1156913016448 catalytic motif [active] 1156913016449 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1156913016450 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1156913016451 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1156913016452 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1156913016453 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1156913016454 active site 1156913016455 putative substrate binding pocket [chemical binding]; other site 1156913016456 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1156913016457 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1156913016458 catalytic loop [active] 1156913016459 iron binding site [ion binding]; other site 1156913016460 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1156913016461 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1156913016462 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1156913016463 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1156913016464 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913016465 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913016466 MarR family; Region: MarR_2; pfam12802 1156913016467 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1156913016468 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1156913016469 catalytic residues [active] 1156913016470 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1156913016471 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913016472 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913016473 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913016474 active site 1156913016475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913016476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913016477 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1156913016478 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1156913016479 Walker A/P-loop; other site 1156913016480 ATP binding site [chemical binding]; other site 1156913016481 Q-loop/lid; other site 1156913016482 ABC transporter signature motif; other site 1156913016483 Walker B; other site 1156913016484 D-loop; other site 1156913016485 H-loop/switch region; other site 1156913016486 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217 1156913016487 active site 1156913016488 malate synthase A; Region: malate_syn_A; TIGR01344 1156913016489 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1156913016490 active site 1156913016491 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1156913016492 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913016493 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913016494 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1156913016495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913016496 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913016497 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1156913016498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913016499 putative substrate translocation pore; other site 1156913016500 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1156913016501 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1156913016502 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1156913016503 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1156913016504 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 1156913016505 Na binding site [ion binding]; other site 1156913016506 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1156913016507 AAA domain; Region: AAA_23; pfam13476 1156913016508 Walker A/P-loop; other site 1156913016509 ATP binding site [chemical binding]; other site 1156913016510 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1156913016511 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1156913016512 ABC transporter signature motif; other site 1156913016513 Walker B; other site 1156913016514 D-loop; other site 1156913016515 H-loop/switch region; other site 1156913016516 acylphosphatase; Provisional; Region: PRK14422 1156913016517 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1156913016518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913016519 active site 1156913016520 phosphorylation site [posttranslational modification] 1156913016521 intermolecular recognition site; other site 1156913016522 dimerization interface [polypeptide binding]; other site 1156913016523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913016524 DNA binding site [nucleotide binding] 1156913016525 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1156913016526 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1156913016527 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1156913016528 Ligand Binding Site [chemical binding]; other site 1156913016529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913016530 dimer interface [polypeptide binding]; other site 1156913016531 phosphorylation site [posttranslational modification] 1156913016532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913016533 ATP binding site [chemical binding]; other site 1156913016534 Mg2+ binding site [ion binding]; other site 1156913016535 G-X-G motif; other site 1156913016536 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1156913016537 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1156913016538 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1156913016539 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1156913016540 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1156913016541 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1156913016542 active site 1156913016543 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1156913016544 dimer interface [polypeptide binding]; other site 1156913016545 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1156913016546 Ligand Binding Site [chemical binding]; other site 1156913016547 Molecular Tunnel; other site 1156913016548 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913016549 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913016550 Walker A/P-loop; other site 1156913016551 ATP binding site [chemical binding]; other site 1156913016552 Q-loop/lid; other site 1156913016553 ABC transporter signature motif; other site 1156913016554 Walker B; other site 1156913016555 D-loop; other site 1156913016556 H-loop/switch region; other site 1156913016557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913016558 DNA-binding site [nucleotide binding]; DNA binding site 1156913016559 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913016560 DNA binding site [nucleotide binding] 1156913016561 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913016562 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913016563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913016564 TPR motif; other site 1156913016565 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913016566 binding surface 1156913016567 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913016568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913016569 binding surface 1156913016570 TPR motif; other site 1156913016571 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913016572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913016573 TPR motif; other site 1156913016574 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913016575 binding surface 1156913016576 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1156913016577 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913016578 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1156913016579 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913016580 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913016581 DNA binding site [nucleotide binding] 1156913016582 domain linker motif; other site 1156913016583 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1156913016584 dimerization interface [polypeptide binding]; other site 1156913016585 ligand binding site [chemical binding]; other site 1156913016586 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1156913016587 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1156913016588 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1156913016589 putative ligand binding site [chemical binding]; other site 1156913016590 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913016591 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913016592 TM-ABC transporter signature motif; other site 1156913016593 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1156913016594 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913016595 Walker A/P-loop; other site 1156913016596 ATP binding site [chemical binding]; other site 1156913016597 Q-loop/lid; other site 1156913016598 ABC transporter signature motif; other site 1156913016599 Walker B; other site 1156913016600 D-loop; other site 1156913016601 H-loop/switch region; other site 1156913016602 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1156913016603 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1156913016604 substrate binding site [chemical binding]; other site 1156913016605 ATP binding site [chemical binding]; other site 1156913016606 KduI/IolB family; Region: KduI; pfam04962 1156913016607 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1156913016608 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1156913016609 PYR/PP interface [polypeptide binding]; other site 1156913016610 dimer interface [polypeptide binding]; other site 1156913016611 TPP binding site [chemical binding]; other site 1156913016612 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1156913016613 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1156913016614 TPP-binding site [chemical binding]; other site 1156913016615 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1156913016616 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1156913016617 NAD binding site [chemical binding]; other site 1156913016618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913016619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913016620 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1156913016621 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1156913016622 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1156913016623 acyl-activating enzyme (AAE) consensus motif; other site 1156913016624 AMP binding site [chemical binding]; other site 1156913016625 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1156913016626 dimer interface [polypeptide binding]; other site 1156913016627 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913016628 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1156913016629 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1156913016630 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913016631 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1156913016632 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1156913016633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913016634 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1156913016635 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1156913016636 putative hydrophobic ligand binding site [chemical binding]; other site 1156913016637 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1156913016638 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1156913016639 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1156913016640 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1156913016641 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1156913016642 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1156913016643 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913016644 catalytic loop [active] 1156913016645 iron binding site [ion binding]; other site 1156913016646 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1156913016647 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1156913016648 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1156913016649 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913016650 catalytic residue [active] 1156913016651 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913016652 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1156913016653 putative DNA binding site [nucleotide binding]; other site 1156913016654 putative Zn2+ binding site [ion binding]; other site 1156913016655 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913016656 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1156913016657 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1156913016658 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1156913016659 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1156913016660 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1156913016661 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1156913016662 metal ion-dependent adhesion site (MIDAS); other site 1156913016663 hypothetical protein; Provisional; Region: PRK06185 1156913016664 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913016665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913016666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913016667 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913016668 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913016669 active site 1156913016670 catalytic tetrad [active] 1156913016671 MoxR-like ATPases [General function prediction only]; Region: COG0714 1156913016672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913016673 Walker A motif; other site 1156913016674 ATP binding site [chemical binding]; other site 1156913016675 Walker B motif; other site 1156913016676 arginine finger; other site 1156913016677 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1156913016678 metal-binding site 1156913016679 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1156913016680 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1156913016681 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913016682 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1156913016683 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1156913016684 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913016685 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913016686 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913016687 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1156913016688 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1156913016689 heterodimer interface [polypeptide binding]; other site 1156913016690 active site 1156913016691 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1156913016692 heterodimer interface [polypeptide binding]; other site 1156913016693 multimer interface [polypeptide binding]; other site 1156913016694 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1156913016695 active site 1156913016696 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1156913016697 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1156913016698 dimer interface [polypeptide binding]; other site 1156913016699 active site 1156913016700 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1156913016701 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1156913016702 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1156913016703 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1156913016704 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1156913016705 potential catalytic triad [active] 1156913016706 conserved cys residue [active] 1156913016707 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1156913016708 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1156913016709 dimerization interface [polypeptide binding]; other site 1156913016710 ligand binding site [chemical binding]; other site 1156913016711 NADP binding site [chemical binding]; other site 1156913016712 catalytic site [active] 1156913016713 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1156913016714 GtrA-like protein; Region: GtrA; pfam04138 1156913016715 Predicted membrane protein [Function unknown]; Region: COG2246 1156913016716 Domain of unknown function (DUF202); Region: DUF202; cl09954 1156913016717 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1156913016718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913016719 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913016720 DNA binding residues [nucleotide binding] 1156913016721 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1156913016722 Amidohydrolase; Region: Amidohydro_2; pfam04909 1156913016723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913016724 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913016725 active site 1156913016726 catalytic tetrad [active] 1156913016727 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1156913016728 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1156913016729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913016730 DNA-binding site [nucleotide binding]; DNA binding site 1156913016731 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1156913016732 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913016733 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913016734 TM-ABC transporter signature motif; other site 1156913016735 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1156913016736 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1156913016737 Walker A/P-loop; other site 1156913016738 ATP binding site [chemical binding]; other site 1156913016739 Q-loop/lid; other site 1156913016740 ABC transporter signature motif; other site 1156913016741 Walker B; other site 1156913016742 D-loop; other site 1156913016743 H-loop/switch region; other site 1156913016744 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1156913016745 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1156913016746 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1156913016747 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1156913016748 ligand binding site [chemical binding]; other site 1156913016749 short chain dehydrogenase; Provisional; Region: PRK06138 1156913016750 classical (c) SDRs; Region: SDR_c; cd05233 1156913016751 NAD(P) binding site [chemical binding]; other site 1156913016752 active site 1156913016753 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1156913016754 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1156913016755 metal binding site [ion binding]; metal-binding site 1156913016756 substrate binding pocket [chemical binding]; other site 1156913016757 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1156913016758 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1156913016759 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1156913016760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913016761 putative substrate translocation pore; other site 1156913016762 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1156913016763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913016764 short chain dehydrogenase; Provisional; Region: PRK07201 1156913016765 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1156913016766 putative NAD(P) binding site [chemical binding]; other site 1156913016767 active site 1156913016768 putative substrate binding site [chemical binding]; other site 1156913016769 classical (c) SDRs; Region: SDR_c; cd05233 1156913016770 NAD(P) binding site [chemical binding]; other site 1156913016771 active site 1156913016772 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1156913016773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913016774 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913016775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913016776 homodimer interface [polypeptide binding]; other site 1156913016777 catalytic residue [active] 1156913016778 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1156913016779 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1156913016780 Walker A/P-loop; other site 1156913016781 ATP binding site [chemical binding]; other site 1156913016782 Q-loop/lid; other site 1156913016783 ABC transporter signature motif; other site 1156913016784 Walker B; other site 1156913016785 D-loop; other site 1156913016786 H-loop/switch region; other site 1156913016787 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1156913016788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913016789 S-adenosylmethionine binding site [chemical binding]; other site 1156913016790 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1156913016791 Transglycosylase; Region: Transgly; pfam00912 1156913016792 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1156913016793 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913016794 dimerization interface [polypeptide binding]; other site 1156913016795 putative DNA binding site [nucleotide binding]; other site 1156913016796 putative Zn2+ binding site [ion binding]; other site 1156913016797 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1156913016798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913016799 DNA-binding site [nucleotide binding]; DNA binding site 1156913016800 FCD domain; Region: FCD; pfam07729 1156913016801 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1156913016802 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1156913016803 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1156913016804 lipoyl synthase; Provisional; Region: PRK05481 1156913016805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913016806 FeS/SAM binding site; other site 1156913016807 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1156913016808 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1156913016809 dimer interface [polypeptide binding]; other site 1156913016810 active site 1156913016811 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1156913016812 folate binding site [chemical binding]; other site 1156913016813 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1156913016814 lipoyl attachment site [posttranslational modification]; other site 1156913016815 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1156913016816 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1156913016817 glycine dehydrogenase; Provisional; Region: PRK05367 1156913016818 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1156913016819 tetramer interface [polypeptide binding]; other site 1156913016820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913016821 catalytic residue [active] 1156913016822 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1156913016823 tetramer interface [polypeptide binding]; other site 1156913016824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913016825 catalytic residue [active] 1156913016826 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1156913016827 dimerization interface [polypeptide binding]; other site 1156913016828 short chain dehydrogenase; Provisional; Region: PRK06057 1156913016829 classical (c) SDRs; Region: SDR_c; cd05233 1156913016830 NAD(P) binding site [chemical binding]; other site 1156913016831 active site 1156913016832 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913016833 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1156913016834 NAD(P) binding site [chemical binding]; other site 1156913016835 catalytic residues [active] 1156913016836 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1156913016837 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1156913016838 catalytic triad [active] 1156913016839 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1156913016840 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1156913016841 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1156913016842 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 1156913016843 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1156913016844 Dimer interface [polypeptide binding]; other site 1156913016845 anticodon binding site; other site 1156913016846 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1156913016847 motif 1; other site 1156913016848 dimer interface [polypeptide binding]; other site 1156913016849 active site 1156913016850 motif 2; other site 1156913016851 motif 3; other site 1156913016852 Predicted membrane protein [Function unknown]; Region: COG4709 1156913016853 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913016854 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1156913016855 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913016856 DNA-binding site [nucleotide binding]; DNA binding site 1156913016857 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1156913016858 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913016859 Walker A/P-loop; other site 1156913016860 ATP binding site [chemical binding]; other site 1156913016861 Q-loop/lid; other site 1156913016862 ABC transporter signature motif; other site 1156913016863 Walker B; other site 1156913016864 D-loop; other site 1156913016865 H-loop/switch region; other site 1156913016866 Mating factor alpha precursor N-terminus; Region: MF_alpha_N; pfam05436 1156913016867 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1156913016868 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1156913016869 DNA binding site [nucleotide binding] 1156913016870 catalytic residue [active] 1156913016871 H2TH interface [polypeptide binding]; other site 1156913016872 putative catalytic residues [active] 1156913016873 turnover-facilitating residue; other site 1156913016874 intercalation triad [nucleotide binding]; other site 1156913016875 8OG recognition residue [nucleotide binding]; other site 1156913016876 putative reading head residues; other site 1156913016877 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1156913016878 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1156913016879 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1156913016880 ribonuclease III; Reviewed; Region: rnc; PRK00102 1156913016881 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1156913016882 dimerization interface [polypeptide binding]; other site 1156913016883 active site 1156913016884 metal binding site [ion binding]; metal-binding site 1156913016885 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1156913016886 dsRNA binding site [nucleotide binding]; other site 1156913016887 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1156913016888 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1156913016889 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1156913016890 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1156913016891 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1156913016892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913016893 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913016894 DNA binding residues [nucleotide binding] 1156913016895 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 1156913016896 active site 1156913016897 barstar interaction site; other site 1156913016898 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1156913016899 active site 1156913016900 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1156913016901 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1156913016902 active site 1156913016903 (T/H)XGH motif; other site 1156913016904 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1156913016905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913016906 S-adenosylmethionine binding site [chemical binding]; other site 1156913016907 Part of AAA domain; Region: AAA_19; pfam13245 1156913016908 Family description; Region: UvrD_C_2; pfam13538 1156913016909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913016910 non-specific DNA binding site [nucleotide binding]; other site 1156913016911 salt bridge; other site 1156913016912 sequence-specific DNA binding site [nucleotide binding]; other site 1156913016913 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1156913016914 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1156913016915 structural tetrad; other site 1156913016916 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1156913016917 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1156913016918 structural tetrad; other site 1156913016919 WD domain, G-beta repeat; Region: WD40; pfam00400 1156913016920 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1156913016921 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913016922 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1156913016923 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1156913016924 Permease; Region: Permease; pfam02405 1156913016925 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1156913016926 Permease; Region: Permease; pfam02405 1156913016927 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913016928 mce related protein; Region: MCE; pfam02470 1156913016929 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1156913016930 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913016931 mce related protein; Region: MCE; pfam02470 1156913016932 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913016933 mce related protein; Region: MCE; pfam02470 1156913016934 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913016935 mce related protein; Region: MCE; pfam02470 1156913016936 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913016937 mce related protein; Region: MCE; pfam02470 1156913016938 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1156913016939 linker region; other site 1156913016940 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1156913016941 mce related protein; Region: MCE; pfam02470 1156913016942 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1156913016943 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1156913016944 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1156913016945 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913016946 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1156913016947 active site 1156913016948 Mn binding site [ion binding]; other site 1156913016949 pyruvate carboxylase; Reviewed; Region: PRK12999 1156913016950 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1156913016951 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1156913016952 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1156913016953 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1156913016954 active site 1156913016955 catalytic residues [active] 1156913016956 metal binding site [ion binding]; metal-binding site 1156913016957 homodimer binding site [polypeptide binding]; other site 1156913016958 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1156913016959 carboxyltransferase (CT) interaction site; other site 1156913016960 biotinylation site [posttranslational modification]; other site 1156913016961 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1156913016962 calcium binding site 2 [ion binding]; other site 1156913016963 active site 1156913016964 catalytic triad [active] 1156913016965 calcium binding site 1 [ion binding]; other site 1156913016966 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1156913016967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913016968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913016969 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913016970 Caspase domain; Region: Peptidase_C14; pfam00656 1156913016971 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1156913016972 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1156913016973 generic binding surface II; other site 1156913016974 ssDNA binding site; other site 1156913016975 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913016976 ATP binding site [chemical binding]; other site 1156913016977 putative Mg++ binding site [ion binding]; other site 1156913016978 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913016979 nucleotide binding region [chemical binding]; other site 1156913016980 ATP-binding site [chemical binding]; other site 1156913016981 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1156913016982 DAK2 domain; Region: Dak2; pfam02734 1156913016983 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1156913016984 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1156913016985 ligand binding site [chemical binding]; other site 1156913016986 active site 1156913016987 UGI interface [polypeptide binding]; other site 1156913016988 catalytic site [active] 1156913016989 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1156913016990 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1156913016991 trimer interface [polypeptide binding]; other site 1156913016992 putative metal binding site [ion binding]; other site 1156913016993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913016994 Coenzyme A binding pocket [chemical binding]; other site 1156913016995 thiamine monophosphate kinase; Provisional; Region: PRK05731 1156913016996 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1156913016997 ATP binding site [chemical binding]; other site 1156913016998 dimerization interface [polypeptide binding]; other site 1156913016999 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913017000 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913017001 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1156913017002 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913017003 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913017004 NAD(P) binding site [chemical binding]; other site 1156913017005 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1156913017006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913017007 DNA-binding site [nucleotide binding]; DNA binding site 1156913017008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913017009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913017010 homodimer interface [polypeptide binding]; other site 1156913017011 catalytic residue [active] 1156913017012 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1156913017013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913017014 dimer interface [polypeptide binding]; other site 1156913017015 phosphorylation site [posttranslational modification] 1156913017016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913017017 ATP binding site [chemical binding]; other site 1156913017018 Mg2+ binding site [ion binding]; other site 1156913017019 G-X-G motif; other site 1156913017020 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913017021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913017022 active site 1156913017023 phosphorylation site [posttranslational modification] 1156913017024 intermolecular recognition site; other site 1156913017025 dimerization interface [polypeptide binding]; other site 1156913017026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913017027 DNA binding site [nucleotide binding] 1156913017028 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1156913017029 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1156913017030 FAD binding pocket [chemical binding]; other site 1156913017031 FAD binding motif [chemical binding]; other site 1156913017032 phosphate binding motif [ion binding]; other site 1156913017033 beta-alpha-beta structure motif; other site 1156913017034 NAD binding pocket [chemical binding]; other site 1156913017035 FMN-binding domain; Region: FMN_bind; pfam04205 1156913017036 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1156913017037 ApbE family; Region: ApbE; pfam02424 1156913017038 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913017039 active site 1156913017040 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 1156913017041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913017042 S-adenosylmethionine binding site [chemical binding]; other site 1156913017043 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1156913017044 active site 1156913017045 homotetramer interface [polypeptide binding]; other site 1156913017046 homodimer interface [polypeptide binding]; other site 1156913017047 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1156913017048 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1156913017049 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1156913017050 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1156913017051 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1156913017052 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1156913017053 putative acyl-acceptor binding pocket; other site 1156913017054 Guanylyl transferase CofC like; Region: CofC; cl17472 1156913017055 polyphosphate kinase; Provisional; Region: PRK05443 1156913017056 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1156913017057 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1156913017058 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1156913017059 putative domain interface [polypeptide binding]; other site 1156913017060 putative active site [active] 1156913017061 catalytic site [active] 1156913017062 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1156913017063 putative domain interface [polypeptide binding]; other site 1156913017064 putative active site [active] 1156913017065 catalytic site [active] 1156913017066 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1156913017067 active site 1156913017068 Ap6A binding site [chemical binding]; other site 1156913017069 nudix motif; other site 1156913017070 metal binding site [ion binding]; metal-binding site 1156913017071 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913017072 catalytic core [active] 1156913017073 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1156913017074 IHF - DNA interface [nucleotide binding]; other site 1156913017075 IHF dimer interface [polypeptide binding]; other site 1156913017076 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1156913017077 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1156913017078 substrate binding site [chemical binding]; other site 1156913017079 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1156913017080 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1156913017081 substrate binding site [chemical binding]; other site 1156913017082 ligand binding site [chemical binding]; other site 1156913017083 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1156913017084 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913017085 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913017086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913017087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913017088 active site 1156913017089 phosphorylation site [posttranslational modification] 1156913017090 intermolecular recognition site; other site 1156913017091 dimerization interface [polypeptide binding]; other site 1156913017092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913017093 DNA binding site [nucleotide binding] 1156913017094 Right handed beta helix region; Region: Beta_helix; pfam13229 1156913017095 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1156913017096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913017097 Walker A motif; other site 1156913017098 ATP binding site [chemical binding]; other site 1156913017099 Walker B motif; other site 1156913017100 arginine finger; other site 1156913017101 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913017102 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913017103 DNA binding residues [nucleotide binding] 1156913017104 dimerization interface [polypeptide binding]; other site 1156913017105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913017106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913017107 active site 1156913017108 phosphorylation site [posttranslational modification] 1156913017109 intermolecular recognition site; other site 1156913017110 dimerization interface [polypeptide binding]; other site 1156913017111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913017112 DNA binding site [nucleotide binding] 1156913017113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913017114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913017115 ATP binding site [chemical binding]; other site 1156913017116 Mg2+ binding site [ion binding]; other site 1156913017117 G-X-G motif; other site 1156913017118 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 1156913017119 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1156913017120 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1156913017121 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1156913017122 active site 1156913017123 catalytic residues [active] 1156913017124 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1156913017125 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913017126 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1156913017127 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913017128 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913017129 Protein of unknown function (DUF690); Region: DUF690; cl04939 1156913017130 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1156913017131 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1156913017132 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913017133 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1156913017134 active site 1156913017135 ATP binding site [chemical binding]; other site 1156913017136 substrate binding site [chemical binding]; other site 1156913017137 activation loop (A-loop); other site 1156913017138 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1156913017139 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1156913017140 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1156913017141 Protein of unknown function DUF58; Region: DUF58; pfam01882 1156913017142 MoxR-like ATPases [General function prediction only]; Region: COG0714 1156913017143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913017144 ATP binding site [chemical binding]; other site 1156913017145 Walker A motif; other site 1156913017146 Walker B motif; other site 1156913017147 arginine finger; other site 1156913017148 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913017149 Interdomain contacts; other site 1156913017150 Cytokine receptor motif; other site 1156913017151 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 1156913017152 TspO/MBR family; Region: TspO_MBR; pfam03073 1156913017153 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1156913017154 active site 1156913017155 NTP binding site [chemical binding]; other site 1156913017156 metal binding triad [ion binding]; metal-binding site 1156913017157 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 1156913017158 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1156913017159 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1156913017160 putative dimer interface [polypeptide binding]; other site 1156913017161 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1156913017162 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1156913017163 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913017164 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1156913017165 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913017166 DNA binding residues [nucleotide binding] 1156913017167 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1156913017168 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913017169 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913017170 catalytic residue [active] 1156913017171 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1156913017172 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1156913017173 anti sigma factor interaction site; other site 1156913017174 regulatory phosphorylation site [posttranslational modification]; other site 1156913017175 Hemerythrin-like domain; Region: Hr-like; cd12108 1156913017176 Fe binding site [ion binding]; other site 1156913017177 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1156913017178 active site 1156913017179 ANTAR domain; Region: ANTAR; pfam03861 1156913017180 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1156913017181 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1156913017182 dimer interface [polypeptide binding]; other site 1156913017183 active site 1156913017184 heme binding site [chemical binding]; other site 1156913017185 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1156913017186 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1156913017187 metal binding site 2 [ion binding]; metal-binding site 1156913017188 putative DNA binding helix; other site 1156913017189 metal binding site 1 [ion binding]; metal-binding site 1156913017190 dimer interface [polypeptide binding]; other site 1156913017191 structural Zn2+ binding site [ion binding]; other site 1156913017192 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1156913017193 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1156913017194 cation binding site [ion binding]; other site 1156913017195 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1156913017196 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1156913017197 dimer interface [polypeptide binding]; other site 1156913017198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913017199 catalytic residue [active] 1156913017200 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1156913017201 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1156913017202 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1156913017203 catalytic residue [active] 1156913017204 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1156913017205 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1156913017206 Amidase; Region: Amidase; cl11426 1156913017207 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913017208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913017209 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1156913017210 putative dimerization interface [polypeptide binding]; other site 1156913017211 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1156913017212 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1156913017213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913017214 Coenzyme A binding pocket [chemical binding]; other site 1156913017215 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913017216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913017217 active site 1156913017218 phosphorylation site [posttranslational modification] 1156913017219 intermolecular recognition site; other site 1156913017220 dimerization interface [polypeptide binding]; other site 1156913017221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913017222 DNA binding residues [nucleotide binding] 1156913017223 dimerization interface [polypeptide binding]; other site 1156913017224 Lamin Tail Domain; Region: LTD; pfam00932 1156913017225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913017226 non-specific DNA binding site [nucleotide binding]; other site 1156913017227 salt bridge; other site 1156913017228 sequence-specific DNA binding site [nucleotide binding]; other site 1156913017229 Lamin Tail Domain; Region: LTD; pfam00932 1156913017230 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1156913017231 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1156913017232 active site 1156913017233 catalytic triad [active] 1156913017234 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1156913017235 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1156913017236 dimerization interface [polypeptide binding]; other site 1156913017237 DNA binding residues [nucleotide binding] 1156913017238 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913017239 dimerization interface [polypeptide binding]; other site 1156913017240 putative DNA binding site [nucleotide binding]; other site 1156913017241 putative Zn2+ binding site [ion binding]; other site 1156913017242 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913017243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913017244 putative substrate translocation pore; other site 1156913017245 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913017246 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1156913017247 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913017248 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913017249 NAD(P) binding site [chemical binding]; other site 1156913017250 catalytic residues [active] 1156913017251 benzoate transport; Region: 2A0115; TIGR00895 1156913017252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913017253 DinB superfamily; Region: DinB_2; pfam12867 1156913017254 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1156913017255 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1156913017256 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1156913017257 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 1156913017258 Cupin domain; Region: Cupin_2; pfam07883 1156913017259 Mif2/CENP-C like; Region: Mif2; pfam11699 1156913017260 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913017261 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1156913017262 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913017263 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1156913017264 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1156913017265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913017266 motif II; other site 1156913017267 hypothetical protein; Provisional; Region: PRK06185 1156913017268 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913017269 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913017270 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1156913017271 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1156913017272 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1156913017273 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1156913017274 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1156913017275 active site 1156913017276 catalytic residues [active] 1156913017277 metal binding site [ion binding]; metal-binding site 1156913017278 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1156913017279 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1156913017280 tartrate dehydrogenase; Region: TTC; TIGR02089 1156913017281 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1156913017282 putative active site [active] 1156913017283 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1156913017284 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1156913017285 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1156913017286 ligand binding site [chemical binding]; other site 1156913017287 NAD binding site [chemical binding]; other site 1156913017288 dimerization interface [polypeptide binding]; other site 1156913017289 catalytic site [active] 1156913017290 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1156913017291 putative L-serine binding site [chemical binding]; other site 1156913017292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913017293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913017294 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1156913017295 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1156913017296 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1156913017297 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1156913017298 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1156913017299 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1156913017300 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1156913017301 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1156913017302 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913017303 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1156913017304 putative NAD(P) binding site [chemical binding]; other site 1156913017305 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913017306 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1156913017307 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1156913017308 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1156913017309 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1156913017310 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1156913017311 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1156913017312 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1156913017313 putative valine binding site [chemical binding]; other site 1156913017314 dimer interface [polypeptide binding]; other site 1156913017315 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1156913017316 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1156913017317 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1156913017318 PYR/PP interface [polypeptide binding]; other site 1156913017319 dimer interface [polypeptide binding]; other site 1156913017320 TPP binding site [chemical binding]; other site 1156913017321 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1156913017322 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1156913017323 TPP-binding site [chemical binding]; other site 1156913017324 dimer interface [polypeptide binding]; other site 1156913017325 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1156913017326 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1156913017327 Protein of unknown function DUF72; Region: DUF72; pfam01904 1156913017328 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 1156913017329 putative ligand binding site [chemical binding]; other site 1156913017330 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1156913017331 putative NAD binding site [chemical binding]; other site 1156913017332 catalytic site [active] 1156913017333 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1156913017334 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913017335 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913017336 Cupin domain; Region: Cupin_2; cl17218 1156913017337 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1156913017338 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1156913017339 GatB domain; Region: GatB_Yqey; smart00845 1156913017340 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1156913017341 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1156913017342 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1156913017343 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1156913017344 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913017345 Coenzyme A binding pocket [chemical binding]; other site 1156913017346 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1156913017347 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1156913017348 nucleotide binding pocket [chemical binding]; other site 1156913017349 K-X-D-G motif; other site 1156913017350 catalytic site [active] 1156913017351 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1156913017352 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1156913017353 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1156913017354 Dimer interface [polypeptide binding]; other site 1156913017355 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1156913017356 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1156913017357 Scramblase; Region: Scramblase; pfam03803 1156913017358 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1156913017359 putative acetyltransferase; Provisional; Region: PRK03624 1156913017360 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913017361 Coenzyme A binding pocket [chemical binding]; other site 1156913017362 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1156913017363 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1156913017364 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1156913017365 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1156913017366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913017367 catalytic residue [active] 1156913017368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913017369 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913017370 putative substrate translocation pore; other site 1156913017371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913017372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913017373 DNA binding residues [nucleotide binding] 1156913017374 dimerization interface [polypeptide binding]; other site 1156913017375 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1156913017376 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913017377 putative NAD(P) binding site [chemical binding]; other site 1156913017378 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1156913017379 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1156913017380 putative acyl-acceptor binding pocket; other site 1156913017381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1156913017382 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1156913017383 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1156913017384 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1156913017385 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1156913017386 Ligand binding site [chemical binding]; other site 1156913017387 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1156913017388 EDD domain protein, DegV family; Region: DegV; TIGR00762 1156913017389 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1156913017390 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913017391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913017392 S-adenosylmethionine binding site [chemical binding]; other site 1156913017393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1156913017394 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1156913017395 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1156913017396 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1156913017397 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1156913017398 catalytic residues [active] 1156913017399 dimer interface [polypeptide binding]; other site 1156913017400 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1156913017401 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1156913017402 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1156913017403 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1156913017404 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1156913017405 malate synthase A; Region: malate_syn_A; TIGR01344 1156913017406 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1156913017407 active site 1156913017408 isocitrate lyase; Provisional; Region: PRK15063 1156913017409 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1156913017410 tetramer interface [polypeptide binding]; other site 1156913017411 active site 1156913017412 Mg2+/Mn2+ binding site [ion binding]; other site 1156913017413 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913017414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913017415 non-specific DNA binding site [nucleotide binding]; other site 1156913017416 salt bridge; other site 1156913017417 sequence-specific DNA binding site [nucleotide binding]; other site 1156913017418 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1156913017419 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1156913017420 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1156913017421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913017422 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1156913017423 NAD(P) binding site [chemical binding]; other site 1156913017424 active site 1156913017425 threonine dehydratase; Validated; Region: PRK08639 1156913017426 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1156913017427 tetramer interface [polypeptide binding]; other site 1156913017428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913017429 catalytic residue [active] 1156913017430 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1156913017431 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1156913017432 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1156913017433 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1156913017434 trimer interface [polypeptide binding]; other site 1156913017435 active site 1156913017436 substrate binding site [chemical binding]; other site 1156913017437 CoA binding site [chemical binding]; other site 1156913017438 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1156913017439 active site 1156913017440 tetramer interface [polypeptide binding]; other site 1156913017441 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1156913017442 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1156913017443 NlpC/P60 family; Region: NLPC_P60; pfam00877 1156913017444 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1156913017445 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913017446 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1156913017447 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1156913017448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913017449 NAD(P) binding site [chemical binding]; other site 1156913017450 active site 1156913017451 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1156913017452 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1156913017453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913017454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913017455 DNA binding residues [nucleotide binding] 1156913017456 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1156913017457 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1156913017458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913017459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913017460 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1156913017461 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1156913017462 substrate binding pocket [chemical binding]; other site 1156913017463 catalytic triad [active] 1156913017464 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1156913017465 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913017466 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913017467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913017468 salt bridge; other site 1156913017469 non-specific DNA binding site [nucleotide binding]; other site 1156913017470 sequence-specific DNA binding site [nucleotide binding]; other site 1156913017471 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913017472 MarR family; Region: MarR; pfam01047 1156913017473 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913017474 LexA repressor; Validated; Region: PRK00215 1156913017475 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1156913017476 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1156913017477 Catalytic site [active] 1156913017478 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1156913017479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913017480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913017481 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913017482 substrate binding site [chemical binding]; other site 1156913017483 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1156913017484 oxyanion hole (OAH) forming residues; other site 1156913017485 trimer interface [polypeptide binding]; other site 1156913017486 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1156913017487 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913017488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913017489 DNA binding residues [nucleotide binding] 1156913017490 SnoaL-like domain; Region: SnoaL_2; pfam12680 1156913017491 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913017492 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1156913017493 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1156913017494 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1156913017495 Di-iron ligands [ion binding]; other site 1156913017496 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1156913017497 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1156913017498 Hemerythrin-like domain; Region: Hr-like; cd12108 1156913017499 Fe binding site [ion binding]; other site 1156913017500 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913017501 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913017502 active site 1156913017503 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1156913017504 Phosphotransferase enzyme family; Region: APH; pfam01636 1156913017505 putative active site [active] 1156913017506 putative substrate binding site [chemical binding]; other site 1156913017507 ATP binding site [chemical binding]; other site 1156913017508 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913017509 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1156913017510 active site 1156913017511 Helix-turn-helix domain; Region: HTH_18; pfam12833 1156913017512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913017513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1156913017514 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 1156913017515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1156913017516 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1156913017517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913017518 S-adenosylmethionine binding site [chemical binding]; other site 1156913017519 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1156913017520 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913017521 substrate binding site [chemical binding]; other site 1156913017522 oxyanion hole (OAH) forming residues; other site 1156913017523 trimer interface [polypeptide binding]; other site 1156913017524 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1156913017525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913017526 Walker A/P-loop; other site 1156913017527 ATP binding site [chemical binding]; other site 1156913017528 Q-loop/lid; other site 1156913017529 ABC transporter signature motif; other site 1156913017530 Walker B; other site 1156913017531 D-loop; other site 1156913017532 H-loop/switch region; other site 1156913017533 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1156913017534 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1156913017535 active site residue [active] 1156913017536 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1156913017537 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1156913017538 Predicted metalloprotease [General function prediction only]; Region: COG2321 1156913017539 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1156913017540 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1156913017541 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1156913017542 Domain of unknown function DUF77; Region: DUF77; pfam01910 1156913017543 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913017544 MarR family; Region: MarR_2; pfam12802 1156913017545 MarR family; Region: MarR_2; cl17246 1156913017546 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1156913017547 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1156913017548 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1156913017549 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913017550 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913017551 DNA binding site [nucleotide binding] 1156913017552 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1156913017553 dimerization interface [polypeptide binding]; other site 1156913017554 ligand binding site [chemical binding]; other site 1156913017555 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1156913017556 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1156913017557 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1156913017558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913017559 Walker A/P-loop; other site 1156913017560 ATP binding site [chemical binding]; other site 1156913017561 Q-loop/lid; other site 1156913017562 ABC transporter signature motif; other site 1156913017563 Walker B; other site 1156913017564 D-loop; other site 1156913017565 H-loop/switch region; other site 1156913017566 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913017567 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913017568 TM-ABC transporter signature motif; other site 1156913017569 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1156913017570 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1156913017571 putative ligand binding site [chemical binding]; other site 1156913017572 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1156913017573 Histidine kinase; Region: His_kinase; pfam06580 1156913017574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913017575 ATP binding site [chemical binding]; other site 1156913017576 Mg2+ binding site [ion binding]; other site 1156913017577 G-X-G motif; other site 1156913017578 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1156913017579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913017580 active site 1156913017581 phosphorylation site [posttranslational modification] 1156913017582 intermolecular recognition site; other site 1156913017583 dimerization interface [polypeptide binding]; other site 1156913017584 LytTr DNA-binding domain; Region: LytTR; smart00850 1156913017585 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1156913017586 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1156913017587 Na binding site [ion binding]; other site 1156913017588 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1156913017589 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1156913017590 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1156913017591 Na binding site [ion binding]; other site 1156913017592 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1156913017593 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1156913017594 tetramer interface [polypeptide binding]; other site 1156913017595 active site 1156913017596 Mg2+/Mn2+ binding site [ion binding]; other site 1156913017597 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1156913017598 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1156913017599 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1156913017600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913017601 DNA-binding site [nucleotide binding]; DNA binding site 1156913017602 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913017603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913017604 homodimer interface [polypeptide binding]; other site 1156913017605 catalytic residue [active] 1156913017606 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1156913017607 active site 1156913017608 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1156913017609 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1156913017610 Walker A; other site 1156913017611 putative acyltransferase; Provisional; Region: PRK05790 1156913017612 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1156913017613 dimer interface [polypeptide binding]; other site 1156913017614 active site 1156913017615 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1156913017616 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913017617 dimer interface [polypeptide binding]; other site 1156913017618 substrate binding site [chemical binding]; other site 1156913017619 metal binding site [ion binding]; metal-binding site 1156913017620 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913017621 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913017622 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913017623 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 1156913017624 NAD(P) binding site [chemical binding]; other site 1156913017625 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1156913017626 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1156913017627 Ligand Binding Site [chemical binding]; other site 1156913017628 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1156913017629 cyclase homology domain; Region: CHD; cd07302 1156913017630 nucleotidyl binding site; other site 1156913017631 metal binding site [ion binding]; metal-binding site 1156913017632 dimer interface [polypeptide binding]; other site 1156913017633 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1156913017634 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1156913017635 NAD(P) binding site [chemical binding]; other site 1156913017636 catalytic residues [active] 1156913017637 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1156913017638 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1156913017639 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1156913017640 minor groove reading motif; other site 1156913017641 helix-hairpin-helix signature motif; other site 1156913017642 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1156913017643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913017644 S-adenosylmethionine binding site [chemical binding]; other site 1156913017645 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1156913017646 amidohydrolase; Region: amidohydrolases; TIGR01891 1156913017647 metal binding site [ion binding]; metal-binding site 1156913017648 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1156913017649 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1156913017650 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1156913017651 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1156913017652 putative active site [active] 1156913017653 putative substrate binding site [chemical binding]; other site 1156913017654 dimer interface [polypeptide binding]; other site 1156913017655 catalytic site [active] 1156913017656 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1156913017657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1156913017658 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1156913017659 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1156913017660 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913017661 active site 1156913017662 substrate binding sites [chemical binding]; other site 1156913017663 Family description; Region: VCBS; pfam13517 1156913017664 Family description; Region: VCBS; pfam13517 1156913017665 Short repeats of unknown function; Region: ALF; pfam03752 1156913017666 Short repeats of unknown function; Region: ALF; pfam03752 1156913017667 Short repeats of unknown function; Region: ALF; pfam03752 1156913017668 Short repeats of unknown function; Region: ALF; pfam03752 1156913017669 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1156913017670 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913017671 DNA binding site [nucleotide binding] 1156913017672 NB-ARC domain; Region: NB-ARC; pfam00931 1156913017673 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913017674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913017675 TPR motif; other site 1156913017676 binding surface 1156913017677 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913017678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913017679 binding surface 1156913017680 TPR motif; other site 1156913017681 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913017682 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913017683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913017684 non-specific DNA binding site [nucleotide binding]; other site 1156913017685 salt bridge; other site 1156913017686 sequence-specific DNA binding site [nucleotide binding]; other site 1156913017687 TIR domain; Region: TIR_2; cl17458 1156913017688 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1156913017689 AAA-like domain; Region: AAA_10; pfam12846 1156913017690 Walker A motif; other site 1156913017691 ATP binding site [chemical binding]; other site 1156913017692 Walker B motif; other site 1156913017693 AAA domain; Region: AAA_31; pfam13614 1156913017694 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1156913017695 P-loop; other site 1156913017696 Magnesium ion binding site [ion binding]; other site 1156913017697 TIR domain; Region: TIR_2; cl17458 1156913017698 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913017699 dimerization interface [polypeptide binding]; other site 1156913017700 putative DNA binding site [nucleotide binding]; other site 1156913017701 putative Zn2+ binding site [ion binding]; other site 1156913017702 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913017703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913017704 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 1156913017705 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1156913017706 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913017707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913017708 Walker A/P-loop; other site 1156913017709 ATP binding site [chemical binding]; other site 1156913017710 Q-loop/lid; other site 1156913017711 ABC transporter signature motif; other site 1156913017712 Walker B; other site 1156913017713 D-loop; other site 1156913017714 H-loop/switch region; other site 1156913017715 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913017716 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1156913017717 enoyl-CoA hydratase; Provisional; Region: PRK12478 1156913017718 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913017719 substrate binding site [chemical binding]; other site 1156913017720 oxyanion hole (OAH) forming residues; other site 1156913017721 trimer interface [polypeptide binding]; other site 1156913017722 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913017723 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1156913017724 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913017725 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913017726 sugar binding site [chemical binding]; other site 1156913017727 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913017728 CARDB; Region: CARDB; pfam07705 1156913017729 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1156913017730 putative metal binding site [ion binding]; other site 1156913017731 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1156913017732 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1156913017733 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1156913017734 G1 box; other site 1156913017735 putative GEF interaction site [polypeptide binding]; other site 1156913017736 GTP/Mg2+ binding site [chemical binding]; other site 1156913017737 Switch I region; other site 1156913017738 G2 box; other site 1156913017739 G3 box; other site 1156913017740 Switch II region; other site 1156913017741 G4 box; other site 1156913017742 G5 box; other site 1156913017743 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1156913017744 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1156913017745 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 1156913017746 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1156913017747 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1156913017748 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913017749 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1156913017750 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1156913017751 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1156913017752 DNA binding residues [nucleotide binding] 1156913017753 putative dimer interface [polypeptide binding]; other site 1156913017754 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1156913017755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913017756 putative substrate translocation pore; other site 1156913017757 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913017758 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1156913017759 inhibitor-cofactor binding pocket; inhibition site 1156913017760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913017761 catalytic residue [active] 1156913017762 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913017763 bile acid transporter; Region: bass; TIGR00841 1156913017764 Sodium Bile acid symporter family; Region: SBF; pfam01758 1156913017765 Electron transfer DM13; Region: DM13; pfam10517 1156913017766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913017767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913017768 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1156913017769 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1156913017770 Cellulose binding domain; Region: CBM_2; pfam00553 1156913017771 Glyco_18 domain; Region: Glyco_18; smart00636 1156913017772 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1156913017773 active site 1156913017774 Cellulose binding domain; Region: CBM_2; pfam00553 1156913017775 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1156913017776 active site 1156913017777 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1156913017778 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1156913017779 Glyco_18 domain; Region: Glyco_18; smart00636 1156913017780 putative active site [active] 1156913017781 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1156913017782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913017783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913017784 DNA binding residues [nucleotide binding] 1156913017785 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913017786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913017787 active site 1156913017788 phosphorylation site [posttranslational modification] 1156913017789 intermolecular recognition site; other site 1156913017790 dimerization interface [polypeptide binding]; other site 1156913017791 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913017792 DNA binding residues [nucleotide binding] 1156913017793 dimerization interface [polypeptide binding]; other site 1156913017794 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1156913017795 GAF domain; Region: GAF; cl17456 1156913017796 Histidine kinase; Region: HisKA_3; pfam07730 1156913017797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913017798 ATP binding site [chemical binding]; other site 1156913017799 Mg2+ binding site [ion binding]; other site 1156913017800 G-X-G motif; other site 1156913017801 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1156913017802 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1156913017803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913017804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913017805 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913017806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913017807 Walker A/P-loop; other site 1156913017808 ATP binding site [chemical binding]; other site 1156913017809 Q-loop/lid; other site 1156913017810 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1156913017811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913017812 Walker A/P-loop; other site 1156913017813 ATP binding site [chemical binding]; other site 1156913017814 Q-loop/lid; other site 1156913017815 ABC transporter; Region: ABC_tran; pfam00005 1156913017816 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913017817 ABC transporter signature motif; other site 1156913017818 Walker B; other site 1156913017819 D-loop; other site 1156913017820 H-loop/switch region; other site 1156913017821 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1156913017822 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913017823 putative active site [active] 1156913017824 putative metal binding site [ion binding]; other site 1156913017825 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1156913017826 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913017827 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913017828 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1156913017829 putative ADP-ribose binding site [chemical binding]; other site 1156913017830 putative active site [active] 1156913017831 translocation protein TolB; Provisional; Region: tolB; PRK03629 1156913017832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913017833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913017834 putative substrate translocation pore; other site 1156913017835 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1156913017836 sugar binding site [chemical binding]; other site 1156913017837 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1156913017838 Interdomain contacts; other site 1156913017839 Cytokine receptor motif; other site 1156913017840 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913017841 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913017842 active site 1156913017843 metal binding site [ion binding]; metal-binding site 1156913017844 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1156913017845 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1156913017846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913017847 motif II; other site 1156913017848 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1156913017849 nudix motif; other site 1156913017850 Predicted membrane protein [Function unknown]; Region: COG2259 1156913017851 Predicted membrane protein [Function unknown]; Region: COG2259 1156913017852 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1156913017853 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1156913017854 G1 box; other site 1156913017855 GTP/Mg2+ binding site [chemical binding]; other site 1156913017856 G2 box; other site 1156913017857 Switch I region; other site 1156913017858 G3 box; other site 1156913017859 Switch II region; other site 1156913017860 G4 box; other site 1156913017861 G5 box; other site 1156913017862 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1156913017863 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1156913017864 Nitrate and nitrite sensing; Region: NIT; pfam08376 1156913017865 sensory histidine kinase CreC; Provisional; Region: PRK11100 1156913017866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913017867 ATP binding site [chemical binding]; other site 1156913017868 Mg2+ binding site [ion binding]; other site 1156913017869 G-X-G motif; other site 1156913017870 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913017871 kynureninase; Region: kynureninase; TIGR01814 1156913017872 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913017873 catalytic residue [active] 1156913017874 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1156913017875 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1156913017876 acyl-activating enzyme (AAE) consensus motif; other site 1156913017877 putative AMP binding site [chemical binding]; other site 1156913017878 putative active site [active] 1156913017879 putative CoA binding site [chemical binding]; other site 1156913017880 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913017881 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1156913017882 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1156913017883 classical (c) SDRs; Region: SDR_c; cd05233 1156913017884 NAD(P) binding site [chemical binding]; other site 1156913017885 active site 1156913017886 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913017887 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913017888 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913017889 metal binding site [ion binding]; metal-binding site 1156913017890 active site 1156913017891 I-site; other site 1156913017892 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1156913017893 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1156913017894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913017895 non-specific DNA binding site [nucleotide binding]; other site 1156913017896 salt bridge; other site 1156913017897 sequence-specific DNA binding site [nucleotide binding]; other site 1156913017898 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1156913017899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1156913017900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913017901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913017902 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1156913017903 DMSO reductase family type II enzyme, molybdopterin subunit; Region: DMSO_red_II_alp; TIGR03479 1156913017904 membrane protein P6; Region: PHA01399 1156913017905 Phage tail protein; Region: Sipho_tail; pfam05709 1156913017906 RibD C-terminal domain; Region: RibD_C; cl17279 1156913017907 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913017908 dimerization interface [polypeptide binding]; other site 1156913017909 putative DNA binding site [nucleotide binding]; other site 1156913017910 putative Zn2+ binding site [ion binding]; other site 1156913017911 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1156913017912 putative hydrophobic ligand binding site [chemical binding]; other site 1156913017913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913017914 S-adenosylmethionine binding site [chemical binding]; other site 1156913017915 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1156913017916 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1156913017917 putative NAD(P) binding site [chemical binding]; other site 1156913017918 homodimer interface [polypeptide binding]; other site 1156913017919 hypothetical protein; Provisional; Region: PRK09266 1156913017920 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1156913017921 substrate-cofactor binding pocket; other site 1156913017922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913017923 catalytic residue [active] 1156913017924 DinB superfamily; Region: DinB_2; pfam12867 1156913017925 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1156913017926 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1156913017927 active site 1156913017928 PHP Thumb interface [polypeptide binding]; other site 1156913017929 metal binding site [ion binding]; metal-binding site 1156913017930 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1156913017931 generic binding surface II; other site 1156913017932 generic binding surface I; other site 1156913017933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913017934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913017935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913017936 dimerization interface [polypeptide binding]; other site 1156913017937 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1156913017938 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1156913017939 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1156913017940 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1156913017941 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1156913017942 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1156913017943 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1156913017944 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1156913017945 active site 1156913017946 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1156913017947 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1156913017948 catalytic triad [active] 1156913017949 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1156913017950 active site 1156913017951 dimerization interface [polypeptide binding]; other site 1156913017952 ribonuclease PH; Reviewed; Region: rph; PRK00173 1156913017953 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1156913017954 hexamer interface [polypeptide binding]; other site 1156913017955 active site 1156913017956 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1156913017957 glutamate racemase; Provisional; Region: PRK00865 1156913017958 Rhomboid family; Region: Rhomboid; pfam01694 1156913017959 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1156913017960 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1156913017961 aspartate racemase; Region: asp_race; TIGR00035 1156913017962 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1156913017963 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1156913017964 dimer interface [polypeptide binding]; other site 1156913017965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913017966 catalytic residue [active] 1156913017967 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1156913017968 MoaE interaction surface [polypeptide binding]; other site 1156913017969 MoeB interaction surface [polypeptide binding]; other site 1156913017970 thiocarboxylated glycine; other site 1156913017971 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1156913017972 MPN+ (JAMM) motif; other site 1156913017973 Zinc-binding site [ion binding]; other site 1156913017974 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1156913017975 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1156913017976 cleavage site 1156913017977 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1156913017978 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1156913017979 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1156913017980 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1156913017981 active site 1156913017982 Isochorismatase family; Region: Isochorismatase; pfam00857 1156913017983 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1156913017984 catalytic triad [active] 1156913017985 conserved cis-peptide bond; other site 1156913017986 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1156913017987 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1156913017988 active site 1156913017989 intersubunit interface [polypeptide binding]; other site 1156913017990 catalytic residue [active] 1156913017991 BioY family; Region: BioY; pfam02632 1156913017992 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1156913017993 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1156913017994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1156913017995 putative Mg++ binding site [ion binding]; other site 1156913017996 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1156913017997 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1156913017998 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913017999 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913018000 active site 1156913018001 ATP binding site [chemical binding]; other site 1156913018002 substrate binding site [chemical binding]; other site 1156913018003 activation loop (A-loop); other site 1156913018004 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 1156913018005 dimer interface [polypeptide binding]; other site 1156913018006 putative active site [active] 1156913018007 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1156913018008 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1156913018009 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1156913018010 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1156913018011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913018012 motif II; other site 1156913018013 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1156913018014 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1156913018015 D-pathway; other site 1156913018016 Putative ubiquinol binding site [chemical binding]; other site 1156913018017 Low-spin heme (heme b) binding site [chemical binding]; other site 1156913018018 Putative water exit pathway; other site 1156913018019 Binuclear center (heme o3/CuB) [ion binding]; other site 1156913018020 K-pathway; other site 1156913018021 Putative proton exit pathway; other site 1156913018022 Phosphotransferase enzyme family; Region: APH; pfam01636 1156913018023 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1156913018024 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1156913018025 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913018026 active site 1156913018027 homodimer interface [polypeptide binding]; other site 1156913018028 TDP-binding site; other site 1156913018029 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1156913018030 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913018031 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913018032 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913018033 Cupin domain; Region: Cupin_2; pfam07883 1156913018034 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913018035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913018036 S-adenosylmethionine binding site [chemical binding]; other site 1156913018037 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913018038 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913018039 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1156913018040 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1156913018041 Conserved TM helix; Region: TM_helix; pfam05552 1156913018042 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1156913018043 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1156913018044 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913018045 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913018046 catalytic residue [active] 1156913018047 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913018048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913018049 putative DNA binding site [nucleotide binding]; other site 1156913018050 putative Zn2+ binding site [ion binding]; other site 1156913018051 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913018052 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1156913018053 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1156913018054 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1156913018055 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1156913018056 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1156913018057 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1156913018058 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1156913018059 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1156913018060 dimerization domain swap beta strand [polypeptide binding]; other site 1156913018061 regulatory protein interface [polypeptide binding]; other site 1156913018062 active site 1156913018063 regulatory phosphorylation site [posttranslational modification]; other site 1156913018064 DAK2 domain; Region: Dak2; cl03685 1156913018065 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1156913018066 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1156913018067 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1156913018068 Na binding site [ion binding]; other site 1156913018069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1156913018070 TPR motif; other site 1156913018071 binding surface 1156913018072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913018073 TPR motif; other site 1156913018074 binding surface 1156913018075 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 1156913018076 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1156913018077 nucleophile elbow; other site 1156913018078 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1156913018079 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1156913018080 hypothetical protein; Provisional; Region: PRK03298 1156913018081 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1156913018082 dimer interface [polypeptide binding]; other site 1156913018083 ADP-ribose binding site [chemical binding]; other site 1156913018084 active site 1156913018085 nudix motif; other site 1156913018086 metal binding site [ion binding]; metal-binding site 1156913018087 enoyl-CoA hydratase; Validated; Region: PRK08139 1156913018088 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913018089 substrate binding site [chemical binding]; other site 1156913018090 oxyanion hole (OAH) forming residues; other site 1156913018091 trimer interface [polypeptide binding]; other site 1156913018092 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1156913018093 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1156913018094 conserved cys residue [active] 1156913018095 Isochorismatase family; Region: Isochorismatase; pfam00857 1156913018096 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1156913018097 catalytic triad [active] 1156913018098 conserved cis-peptide bond; other site 1156913018099 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1156913018100 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1156913018101 Walker A/P-loop; other site 1156913018102 ATP binding site [chemical binding]; other site 1156913018103 Q-loop/lid; other site 1156913018104 ABC transporter signature motif; other site 1156913018105 Walker B; other site 1156913018106 D-loop; other site 1156913018107 H-loop/switch region; other site 1156913018108 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1156913018109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913018110 dimer interface [polypeptide binding]; other site 1156913018111 conserved gate region; other site 1156913018112 putative PBP binding loops; other site 1156913018113 ABC-ATPase subunit interface; other site 1156913018114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913018115 dimer interface [polypeptide binding]; other site 1156913018116 conserved gate region; other site 1156913018117 putative PBP binding loops; other site 1156913018118 ABC-ATPase subunit interface; other site 1156913018119 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913018120 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1156913018121 substrate binding pocket [chemical binding]; other site 1156913018122 membrane-bound complex binding site; other site 1156913018123 hinge residues; other site 1156913018124 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1156913018125 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1156913018126 B12 binding site [chemical binding]; other site 1156913018127 LysE type translocator; Region: LysE; cl00565 1156913018128 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1156913018129 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1156913018130 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1156913018131 hinge; other site 1156913018132 active site 1156913018133 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1156913018134 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1156913018135 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1156913018136 hinge; other site 1156913018137 active site 1156913018138 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1156913018139 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1156913018140 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1156913018141 gamma subunit interface [polypeptide binding]; other site 1156913018142 epsilon subunit interface [polypeptide binding]; other site 1156913018143 LBP interface [polypeptide binding]; other site 1156913018144 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1156913018145 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1156913018146 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1156913018147 alpha subunit interaction interface [polypeptide binding]; other site 1156913018148 Walker A motif; other site 1156913018149 ATP binding site [chemical binding]; other site 1156913018150 Walker B motif; other site 1156913018151 inhibitor binding site; inhibition site 1156913018152 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1156913018153 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1156913018154 core domain interface [polypeptide binding]; other site 1156913018155 delta subunit interface [polypeptide binding]; other site 1156913018156 epsilon subunit interface [polypeptide binding]; other site 1156913018157 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1156913018158 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1156913018159 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1156913018160 beta subunit interaction interface [polypeptide binding]; other site 1156913018161 Walker A motif; other site 1156913018162 ATP binding site [chemical binding]; other site 1156913018163 Walker B motif; other site 1156913018164 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1156913018165 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1156913018166 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1156913018167 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1156913018168 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1156913018169 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1156913018170 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1156913018171 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1156913018172 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1156913018173 Mg++ binding site [ion binding]; other site 1156913018174 putative catalytic motif [active] 1156913018175 substrate binding site [chemical binding]; other site 1156913018176 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1156913018177 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1156913018178 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1156913018179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913018180 S-adenosylmethionine binding site [chemical binding]; other site 1156913018181 HD domain; Region: HD_3; pfam13023 1156913018182 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1156913018183 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913018184 DNA binding residues [nucleotide binding] 1156913018185 putative dimer interface [polypeptide binding]; other site 1156913018186 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1156913018187 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1156913018188 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1156913018189 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1156913018190 RF-1 domain; Region: RF-1; pfam00472 1156913018191 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1156913018192 AAA domain; Region: AAA_17; pfam13207 1156913018193 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1156913018194 transcription termination factor Rho; Provisional; Region: PRK12608 1156913018195 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1156913018196 RNA binding site [nucleotide binding]; other site 1156913018197 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1156913018198 multimer interface [polypeptide binding]; other site 1156913018199 Walker A motif; other site 1156913018200 ATP binding site [chemical binding]; other site 1156913018201 Walker B motif; other site 1156913018202 homoserine kinase; Provisional; Region: PRK01212 1156913018203 threonine synthase; Reviewed; Region: PRK06721 1156913018204 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1156913018205 homodimer interface [polypeptide binding]; other site 1156913018206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913018207 catalytic residue [active] 1156913018208 homoserine dehydrogenase; Provisional; Region: PRK06349 1156913018209 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1156913018210 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1156913018211 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1156913018212 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1156913018213 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1156913018214 active site 1156913018215 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1156913018216 substrate binding site [chemical binding]; other site 1156913018217 catalytic residues [active] 1156913018218 dimer interface [polypeptide binding]; other site 1156913018219 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1156913018220 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1156913018221 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1156913018222 active site 1156913018223 HIGH motif; other site 1156913018224 KMSK motif region; other site 1156913018225 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1156913018226 tRNA binding surface [nucleotide binding]; other site 1156913018227 anticodon binding site; other site 1156913018228 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1156913018229 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1156913018230 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1156913018231 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1156913018232 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913018233 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1156913018234 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1156913018235 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913018236 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913018237 catalytic residue [active] 1156913018238 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1156913018239 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1156913018240 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1156913018241 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1156913018242 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1156913018243 acyl-activating enzyme (AAE) consensus motif; other site 1156913018244 active site 1156913018245 AMP binding site [chemical binding]; other site 1156913018246 substrate binding site [chemical binding]; other site 1156913018247 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1156913018248 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913018249 acyl-activating enzyme (AAE) consensus motif; other site 1156913018250 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1156913018251 acyl-activating enzyme (AAE) consensus motif; other site 1156913018252 putative AMP binding site [chemical binding]; other site 1156913018253 putative active site [active] 1156913018254 putative CoA binding site [chemical binding]; other site 1156913018255 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913018256 Cytochrome P450; Region: p450; cl12078 1156913018257 hypothetical protein; Provisional; Region: PRK06208 1156913018258 intersubunit interface [polypeptide binding]; other site 1156913018259 active site 1156913018260 Zn2+ binding site [ion binding]; other site 1156913018261 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1156913018262 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1156913018263 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913018264 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1156913018265 active site 1156913018266 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1156913018267 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1156913018268 active site 1156913018269 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1156913018270 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1156913018271 active site 1156913018272 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1156913018273 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1156913018274 dimer interface [polypeptide binding]; other site 1156913018275 active site 1156913018276 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1156913018277 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1156913018278 active site 2 [active] 1156913018279 active site 1 [active] 1156913018280 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1156913018281 active site 2 [active] 1156913018282 active site 1 [active] 1156913018283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913018284 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1156913018285 NAD(P) binding site [chemical binding]; other site 1156913018286 active site 1156913018287 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1156913018288 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1156913018289 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1156913018290 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1156913018291 dimer interface [polypeptide binding]; other site 1156913018292 active site 1156913018293 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913018294 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913018295 active site 1156913018296 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1156913018297 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913018298 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1156913018299 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1156913018300 active site 1156913018301 dimer interface [polypeptide binding]; other site 1156913018302 non-prolyl cis peptide bond; other site 1156913018303 insertion regions; other site 1156913018304 Neocarzinostatin family; Region: Neocarzinostat; pfam00960 1156913018305 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913018306 Cytochrome P450; Region: p450; cl12078 1156913018307 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1156913018308 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913018309 active site 1156913018310 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913018311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913018312 S-adenosylmethionine binding site [chemical binding]; other site 1156913018313 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913018314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913018315 NAD(P) binding site [chemical binding]; other site 1156913018316 active site 1156913018317 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913018318 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1156913018319 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1156913018320 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1156913018321 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913018322 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1156913018323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1156913018324 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1156913018325 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1156913018326 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913018327 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913018328 active site 1156913018329 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1156913018330 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1156913018331 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913018332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913018333 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1156913018334 Walker A/P-loop; other site 1156913018335 ATP binding site [chemical binding]; other site 1156913018336 Q-loop/lid; other site 1156913018337 ABC transporter signature motif; other site 1156913018338 Walker B; other site 1156913018339 D-loop; other site 1156913018340 H-loop/switch region; other site 1156913018341 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913018342 Cytochrome P450; Region: p450; cl12078 1156913018343 RibD C-terminal domain; Region: RibD_C; cl17279 1156913018344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913018345 Walker A/P-loop; other site 1156913018346 ATP binding site [chemical binding]; other site 1156913018347 Q-loop/lid; other site 1156913018348 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1156913018349 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1156913018350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913018351 Walker A/P-loop; other site 1156913018352 ATP binding site [chemical binding]; other site 1156913018353 Q-loop/lid; other site 1156913018354 ABC transporter signature motif; other site 1156913018355 Walker B; other site 1156913018356 D-loop; other site 1156913018357 H-loop/switch region; other site 1156913018358 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1156913018359 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913018360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913018361 active site 1156913018362 phosphorylation site [posttranslational modification] 1156913018363 intermolecular recognition site; other site 1156913018364 dimerization interface [polypeptide binding]; other site 1156913018365 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913018366 DNA binding residues [nucleotide binding] 1156913018367 dimerization interface [polypeptide binding]; other site 1156913018368 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1156913018369 hydrophobic ligand binding site; other site 1156913018370 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1156913018371 homotrimer interaction site [polypeptide binding]; other site 1156913018372 putative active site [active] 1156913018373 FtsI repressor; Provisional; Region: PRK10883 1156913018374 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1156913018375 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1156913018376 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913018377 Histidine kinase; Region: HisKA_3; pfam07730 1156913018378 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913018379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913018380 active site 1156913018381 phosphorylation site [posttranslational modification] 1156913018382 intermolecular recognition site; other site 1156913018383 dimerization interface [polypeptide binding]; other site 1156913018384 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913018385 DNA binding residues [nucleotide binding] 1156913018386 dimerization interface [polypeptide binding]; other site 1156913018387 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1156913018388 RibD C-terminal domain; Region: RibD_C; cl17279 1156913018389 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1156913018390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913018391 NAD(P) binding site [chemical binding]; other site 1156913018392 active site 1156913018393 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913018394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913018395 short chain dehydrogenase; Provisional; Region: PRK06172 1156913018396 classical (c) SDRs; Region: SDR_c; cd05233 1156913018397 NAD(P) binding site [chemical binding]; other site 1156913018398 active site 1156913018399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913018400 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1156913018401 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1156913018402 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1156913018403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913018404 catalytic residue [active] 1156913018405 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1156913018406 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1156913018407 putative ligand binding residues [chemical binding]; other site 1156913018408 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1156913018409 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1156913018410 Walker A/P-loop; other site 1156913018411 ATP binding site [chemical binding]; other site 1156913018412 Q-loop/lid; other site 1156913018413 ABC transporter signature motif; other site 1156913018414 Walker B; other site 1156913018415 D-loop; other site 1156913018416 H-loop/switch region; other site 1156913018417 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1156913018418 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913018419 dimer interface [polypeptide binding]; other site 1156913018420 putative PBP binding regions; other site 1156913018421 ABC-ATPase subunit interface; other site 1156913018422 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1156913018423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913018424 S-adenosylmethionine binding site [chemical binding]; other site 1156913018425 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1156913018426 tricarballylate dehydrogenase; Validated; Region: PRK08274 1156913018427 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1156913018428 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1156913018429 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913018430 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1156913018431 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1156913018432 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1156913018433 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1156913018434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913018435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913018436 putative substrate translocation pore; other site 1156913018437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913018438 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1156913018439 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1156913018440 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1156913018441 YCII-related domain; Region: YCII; cl00999 1156913018442 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1156913018443 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1156913018444 Domain of unknown function (DUF385); Region: DUF385; cl04387 1156913018445 Hemerythrin-like domain; Region: Hr-like; cd12108 1156913018446 Fe binding site [ion binding]; other site 1156913018447 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913018448 MarR family; Region: MarR_2; pfam12802 1156913018449 YCII-related domain; Region: YCII; cl00999 1156913018450 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1156913018451 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913018452 NAD(P) binding site [chemical binding]; other site 1156913018453 active site 1156913018454 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1156913018455 PAC2 family; Region: PAC2; pfam09754 1156913018456 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1156913018457 Predicted membrane protein [Function unknown]; Region: COG3428 1156913018458 Bacterial PH domain; Region: DUF304; pfam03703 1156913018459 Bacterial PH domain; Region: DUF304; pfam03703 1156913018460 short chain dehydrogenase; Provisional; Region: PRK08303 1156913018461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913018462 NAD(P) binding site [chemical binding]; other site 1156913018463 active site 1156913018464 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913018465 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1156913018466 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913018467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913018468 Coenzyme A binding pocket [chemical binding]; other site 1156913018469 active site 1156913018470 metal binding site [ion binding]; metal-binding site 1156913018471 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1156913018472 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1156913018473 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913018474 inhibitor-cofactor binding pocket; inhibition site 1156913018475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913018476 catalytic residue [active] 1156913018477 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1156913018478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913018479 DNA-binding site [nucleotide binding]; DNA binding site 1156913018480 FCD domain; Region: FCD; pfam07729 1156913018481 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1156913018482 classical (c) SDRs; Region: SDR_c; cd05233 1156913018483 NAD(P) binding site [chemical binding]; other site 1156913018484 active site 1156913018485 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1156913018486 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1156913018487 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1156913018488 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1156913018489 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1156913018490 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1156913018491 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1156913018492 PYR/PP interface [polypeptide binding]; other site 1156913018493 dimer interface [polypeptide binding]; other site 1156913018494 TPP binding site [chemical binding]; other site 1156913018495 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1156913018496 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1156913018497 TPP-binding site [chemical binding]; other site 1156913018498 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1156913018499 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1156913018500 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1156913018501 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1156913018502 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1156913018503 putative dimer interface [polypeptide binding]; other site 1156913018504 N-terminal domain interface [polypeptide binding]; other site 1156913018505 putative substrate binding pocket (H-site) [chemical binding]; other site 1156913018506 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1156913018507 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1156913018508 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1156913018509 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1156913018510 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1156913018511 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 1156913018512 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1156913018513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913018514 FeS/SAM binding site; other site 1156913018515 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1156913018516 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1156913018517 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1156913018518 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913018519 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913018520 active site 1156913018521 catalytic tetrad [active] 1156913018522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913018523 dimerization interface [polypeptide binding]; other site 1156913018524 putative DNA binding site [nucleotide binding]; other site 1156913018525 putative Zn2+ binding site [ion binding]; other site 1156913018526 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913018527 putative amidase; Provisional; Region: PRK06169 1156913018528 Amidase; Region: Amidase; pfam01425 1156913018529 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1156913018530 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1156913018531 NAD binding site [chemical binding]; other site 1156913018532 ligand binding site [chemical binding]; other site 1156913018533 catalytic site [active] 1156913018534 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1156913018535 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1156913018536 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1156913018537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913018538 DNA-binding site [nucleotide binding]; DNA binding site 1156913018539 FCD domain; Region: FCD; pfam07729 1156913018540 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1156913018541 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1156913018542 tartrate dehydrogenase; Region: TTC; TIGR02089 1156913018543 succinic semialdehyde dehydrogenase; Region: PLN02278 1156913018544 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1156913018545 tetramerization interface [polypeptide binding]; other site 1156913018546 NAD(P) binding site [chemical binding]; other site 1156913018547 catalytic residues [active] 1156913018548 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 1156913018549 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913018550 inhibitor-cofactor binding pocket; inhibition site 1156913018551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913018552 catalytic residue [active] 1156913018553 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 1156913018554 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913018555 DNA binding site [nucleotide binding] 1156913018556 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913018557 AAA domain; Region: AAA_22; pfam13401 1156913018558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913018559 binding surface 1156913018560 TPR motif; other site 1156913018561 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913018562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913018563 TPR motif; other site 1156913018564 binding surface 1156913018565 TPR repeat; Region: TPR_11; pfam13414 1156913018566 Calx-beta domain; Region: Calx-beta; cl02522 1156913018567 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913018568 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1156913018569 hypothetical protein; Validated; Region: PRK07586 1156913018570 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1156913018571 PYR/PP interface [polypeptide binding]; other site 1156913018572 dimer interface [polypeptide binding]; other site 1156913018573 TPP binding site [chemical binding]; other site 1156913018574 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1156913018575 TPP-binding site [chemical binding]; other site 1156913018576 dimer interface [polypeptide binding]; other site 1156913018577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913018578 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913018579 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 1156913018580 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1156913018581 putative hydrophobic ligand binding site [chemical binding]; other site 1156913018582 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1156913018583 putative hydrophobic ligand binding site [chemical binding]; other site 1156913018584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913018585 dimerization interface [polypeptide binding]; other site 1156913018586 putative DNA binding site [nucleotide binding]; other site 1156913018587 putative Zn2+ binding site [ion binding]; other site 1156913018588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913018589 Histidine kinase; Region: HisKA_3; pfam07730 1156913018590 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541 1156913018591 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913018592 Mg2+ binding site [ion binding]; other site 1156913018593 G-X-G motif; other site 1156913018594 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913018595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913018596 active site 1156913018597 phosphorylation site [posttranslational modification] 1156913018598 intermolecular recognition site; other site 1156913018599 dimerization interface [polypeptide binding]; other site 1156913018600 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913018601 DNA binding residues [nucleotide binding] 1156913018602 dimerization interface [polypeptide binding]; other site 1156913018603 MMPL family; Region: MMPL; pfam03176 1156913018604 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1156913018605 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913018606 substrate binding site [chemical binding]; other site 1156913018607 oxyanion hole (OAH) forming residues; other site 1156913018608 trimer interface [polypeptide binding]; other site 1156913018609 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1156913018610 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1156913018611 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1156913018612 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1156913018613 dimer interface [polypeptide binding]; other site 1156913018614 active site 1156913018615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913018616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913018617 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913018618 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913018619 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1156913018620 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1156913018621 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913018622 active site 1156913018623 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913018624 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913018625 active site 1156913018626 MASE1; Region: MASE1; cl17823 1156913018627 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1156913018628 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1156913018629 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1156913018630 classical (c) SDRs; Region: SDR_c; cd05233 1156913018631 NAD(P) binding site [chemical binding]; other site 1156913018632 active site 1156913018633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913018634 Coenzyme A binding pocket [chemical binding]; other site 1156913018635 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1156913018636 active site 1156913018637 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913018638 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913018639 active site 1156913018640 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1156913018641 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1156913018642 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1156913018643 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1156913018644 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1156913018645 carboxyltransferase (CT) interaction site; other site 1156913018646 biotinylation site [posttranslational modification]; other site 1156913018647 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1156913018648 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1156913018649 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1156913018650 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1156913018651 active site 1156913018652 oxyanion hole [active] 1156913018653 catalytic triad [active] 1156913018654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913018655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913018656 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1156913018657 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1156913018658 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1156913018659 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1156913018660 homodimer interface [polypeptide binding]; other site 1156913018661 substrate-cofactor binding pocket; other site 1156913018662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913018663 catalytic residue [active] 1156913018664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913018665 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1156913018666 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913018667 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1156913018668 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1156913018669 putative dimer interface [polypeptide binding]; other site 1156913018670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913018671 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1156913018672 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913018673 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1156913018674 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913018675 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 1156913018676 putative NAD(P) binding site [chemical binding]; other site 1156913018677 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1156913018678 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1156913018679 hexamer interface [polypeptide binding]; other site 1156913018680 ligand binding site [chemical binding]; other site 1156913018681 putative active site [active] 1156913018682 NAD(P) binding site [chemical binding]; other site 1156913018683 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913018684 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913018685 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913018686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913018687 binding surface 1156913018688 TPR motif; other site 1156913018689 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913018690 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913018691 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913018692 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913018693 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1156913018694 Walker A/P-loop; other site 1156913018695 ATP binding site [chemical binding]; other site 1156913018696 Q-loop/lid; other site 1156913018697 ABC transporter signature motif; other site 1156913018698 Walker B; other site 1156913018699 D-loop; other site 1156913018700 H-loop/switch region; other site 1156913018701 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913018702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913018703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913018704 Walker A/P-loop; other site 1156913018705 ATP binding site [chemical binding]; other site 1156913018706 Q-loop/lid; other site 1156913018707 ABC transporter signature motif; other site 1156913018708 Walker B; other site 1156913018709 D-loop; other site 1156913018710 H-loop/switch region; other site 1156913018711 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913018712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913018713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913018714 Walker A/P-loop; other site 1156913018715 ATP binding site [chemical binding]; other site 1156913018716 Q-loop/lid; other site 1156913018717 ABC transporter signature motif; other site 1156913018718 Walker B; other site 1156913018719 D-loop; other site 1156913018720 H-loop/switch region; other site 1156913018721 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1156913018722 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1156913018723 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1156913018724 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1156913018725 TPP-binding site [chemical binding]; other site 1156913018726 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1156913018727 dimer interface [polypeptide binding]; other site 1156913018728 PYR/PP interface [polypeptide binding]; other site 1156913018729 TPP binding site [chemical binding]; other site 1156913018730 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1156913018731 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1156913018732 calcium binding site 2 [ion binding]; other site 1156913018733 active site 1156913018734 catalytic triad [active] 1156913018735 calcium binding site 1 [ion binding]; other site 1156913018736 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1156913018737 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1156913018738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913018739 Coenzyme A binding pocket [chemical binding]; other site 1156913018740 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1156913018741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913018742 ABC-ATPase subunit interface; other site 1156913018743 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1156913018744 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1156913018745 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1156913018746 Walker A/P-loop; other site 1156913018747 ATP binding site [chemical binding]; other site 1156913018748 Q-loop/lid; other site 1156913018749 ABC transporter signature motif; other site 1156913018750 Walker B; other site 1156913018751 D-loop; other site 1156913018752 H-loop/switch region; other site 1156913018753 Predicted methyltransferases [General function prediction only]; Region: COG1568 1156913018754 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1156913018755 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1156913018756 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1156913018757 putative NAD(P) binding site [chemical binding]; other site 1156913018758 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1156913018759 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1156913018760 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1156913018761 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1156913018762 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1156913018763 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1156913018764 CoenzymeA binding site [chemical binding]; other site 1156913018765 subunit interaction site [polypeptide binding]; other site 1156913018766 PHB binding site; other site 1156913018767 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913018768 catalytic core [active] 1156913018769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913018770 Coenzyme A binding pocket [chemical binding]; other site 1156913018771 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1156913018772 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1156913018773 Transcription factor WhiB; Region: Whib; pfam02467 1156913018774 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1156913018775 PAS fold; Region: PAS_4; pfam08448 1156913018776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1156913018777 Histidine kinase; Region: HisKA_2; pfam07568 1156913018778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913018779 ATP binding site [chemical binding]; other site 1156913018780 Mg2+ binding site [ion binding]; other site 1156913018781 G-X-G motif; other site 1156913018782 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1156913018783 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913018784 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913018785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913018786 DNA binding residues [nucleotide binding] 1156913018787 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1156913018788 putative deacylase active site [active] 1156913018789 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1156913018790 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1156913018791 Predicted GTPases [General function prediction only]; Region: COG1162 1156913018792 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1156913018793 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1156913018794 GTP/Mg2+ binding site [chemical binding]; other site 1156913018795 G4 box; other site 1156913018796 G1 box; other site 1156913018797 Switch I region; other site 1156913018798 G2 box; other site 1156913018799 G3 box; other site 1156913018800 Switch II region; other site 1156913018801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913018802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913018803 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913018804 NAD(P) binding site [chemical binding]; other site 1156913018805 active site 1156913018806 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1156913018807 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1156913018808 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1156913018809 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1156913018810 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1156913018811 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1156913018812 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1156913018813 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1156913018814 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1156913018815 30S subunit binding site; other site 1156913018816 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1156913018817 active site 1156913018818 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1156913018819 lipoprotein LpqB; Provisional; Region: PRK13616 1156913018820 Sporulation and spore germination; Region: Germane; pfam10646 1156913018821 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1156913018822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913018823 dimerization interface [polypeptide binding]; other site 1156913018824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913018825 dimer interface [polypeptide binding]; other site 1156913018826 phosphorylation site [posttranslational modification] 1156913018827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913018828 ATP binding site [chemical binding]; other site 1156913018829 Mg2+ binding site [ion binding]; other site 1156913018830 G-X-G motif; other site 1156913018831 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913018832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913018833 active site 1156913018834 phosphorylation site [posttranslational modification] 1156913018835 intermolecular recognition site; other site 1156913018836 dimerization interface [polypeptide binding]; other site 1156913018837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913018838 DNA binding site [nucleotide binding] 1156913018839 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1156913018840 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913018841 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1156913018842 [2Fe-2S] cluster binding site [ion binding]; other site 1156913018843 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1156913018844 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913018845 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913018846 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1156913018847 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1156913018848 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1156913018849 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1156913018850 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1156913018851 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1156913018852 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1156913018853 [2Fe-2S] cluster binding site [ion binding]; other site 1156913018854 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1156913018855 putative alpha subunit interface [polypeptide binding]; other site 1156913018856 putative active site [active] 1156913018857 putative substrate binding site [chemical binding]; other site 1156913018858 Fe binding site [ion binding]; other site 1156913018859 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1156913018860 TMP-binding site; other site 1156913018861 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1156913018862 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1156913018863 homotetramer interface [polypeptide binding]; other site 1156913018864 ligand binding site [chemical binding]; other site 1156913018865 catalytic site [active] 1156913018866 NAD binding site [chemical binding]; other site 1156913018867 amino acid transporter; Region: 2A0306; TIGR00909 1156913018868 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1156913018869 Cation efflux family; Region: Cation_efflux; pfam01545 1156913018870 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913018871 AAA ATPase domain; Region: AAA_16; pfam13191 1156913018872 NACHT domain; Region: NACHT; pfam05729 1156913018873 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1156913018874 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1156913018875 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1156913018876 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1156913018877 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1156913018878 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1156913018879 active site 1156913018880 substrate binding site [chemical binding]; other site 1156913018881 metal binding site [ion binding]; metal-binding site 1156913018882 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1156913018883 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1156913018884 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1156913018885 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913018886 active site 1156913018887 Transcription factor WhiB; Region: Whib; pfam02467 1156913018888 Peptidase family M50; Region: Peptidase_M50; pfam02163 1156913018889 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1156913018890 active site 1156913018891 putative substrate binding region [chemical binding]; other site 1156913018892 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1156913018893 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1156913018894 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913018895 Walker A/P-loop; other site 1156913018896 ATP binding site [chemical binding]; other site 1156913018897 Q-loop/lid; other site 1156913018898 ABC transporter signature motif; other site 1156913018899 Walker B; other site 1156913018900 D-loop; other site 1156913018901 H-loop/switch region; other site 1156913018902 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1156913018903 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913018904 Walker A/P-loop; other site 1156913018905 ATP binding site [chemical binding]; other site 1156913018906 Q-loop/lid; other site 1156913018907 ABC transporter signature motif; other site 1156913018908 Walker B; other site 1156913018909 D-loop; other site 1156913018910 H-loop/switch region; other site 1156913018911 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1156913018912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1156913018913 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1156913018914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913018915 dimer interface [polypeptide binding]; other site 1156913018916 conserved gate region; other site 1156913018917 putative PBP binding loops; other site 1156913018918 ABC-ATPase subunit interface; other site 1156913018919 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1156913018920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913018921 putative PBP binding loops; other site 1156913018922 dimer interface [polypeptide binding]; other site 1156913018923 ABC-ATPase subunit interface; other site 1156913018924 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1156913018925 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1156913018926 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1156913018927 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1156913018928 Helix-turn-helix domain; Region: HTH_38; pfam13936 1156913018929 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1156913018930 Integrase core domain; Region: rve; pfam00665 1156913018931 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1156913018932 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1156913018933 G1 box; other site 1156913018934 putative GEF interaction site [polypeptide binding]; other site 1156913018935 GTP/Mg2+ binding site [chemical binding]; other site 1156913018936 Switch I region; other site 1156913018937 G2 box; other site 1156913018938 G3 box; other site 1156913018939 Switch II region; other site 1156913018940 G4 box; other site 1156913018941 G5 box; other site 1156913018942 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1156913018943 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1156913018944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1156913018945 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1156913018946 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1156913018947 active site 1156913018948 HIGH motif; other site 1156913018949 dimer interface [polypeptide binding]; other site 1156913018950 KMSKS motif; other site 1156913018951 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1156913018952 active site 1156913018953 8-oxo-dGMP binding site [chemical binding]; other site 1156913018954 nudix motif; other site 1156913018955 metal binding site [ion binding]; metal-binding site 1156913018956 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1156913018957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913018958 dimer interface [polypeptide binding]; other site 1156913018959 phosphorylation site [posttranslational modification] 1156913018960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913018961 ATP binding site [chemical binding]; other site 1156913018962 Mg2+ binding site [ion binding]; other site 1156913018963 G-X-G motif; other site 1156913018964 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913018965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913018966 active site 1156913018967 phosphorylation site [posttranslational modification] 1156913018968 intermolecular recognition site; other site 1156913018969 dimerization interface [polypeptide binding]; other site 1156913018970 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913018971 DNA binding site [nucleotide binding] 1156913018972 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1156913018973 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913018974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913018975 Walker A/P-loop; other site 1156913018976 ATP binding site [chemical binding]; other site 1156913018977 Q-loop/lid; other site 1156913018978 ABC transporter signature motif; other site 1156913018979 Walker B; other site 1156913018980 D-loop; other site 1156913018981 H-loop/switch region; other site 1156913018982 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913018983 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913018984 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1156913018985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913018986 Walker A/P-loop; other site 1156913018987 ATP binding site [chemical binding]; other site 1156913018988 Q-loop/lid; other site 1156913018989 ABC transporter signature motif; other site 1156913018990 Walker B; other site 1156913018991 D-loop; other site 1156913018992 H-loop/switch region; other site 1156913018993 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1156913018994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1156913018995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913018996 dimer interface [polypeptide binding]; other site 1156913018997 conserved gate region; other site 1156913018998 putative PBP binding loops; other site 1156913018999 ABC-ATPase subunit interface; other site 1156913019000 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1156913019001 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1156913019002 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1156913019003 aromatic arch; other site 1156913019004 DCoH dimer interaction site [polypeptide binding]; other site 1156913019005 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1156913019006 DCoH tetramer interaction site [polypeptide binding]; other site 1156913019007 substrate binding site [chemical binding]; other site 1156913019008 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913019009 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913019010 Fic/DOC family; Region: Fic; cl00960 1156913019011 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1156913019012 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1156913019013 PA/protease or protease-like domain interface [polypeptide binding]; other site 1156913019014 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1156913019015 Peptidase family M28; Region: Peptidase_M28; pfam04389 1156913019016 metal binding site [ion binding]; metal-binding site 1156913019017 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1156913019018 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1156913019019 GTP-binding protein YchF; Reviewed; Region: PRK09601 1156913019020 YchF GTPase; Region: YchF; cd01900 1156913019021 G1 box; other site 1156913019022 GTP/Mg2+ binding site [chemical binding]; other site 1156913019023 Switch I region; other site 1156913019024 G2 box; other site 1156913019025 Switch II region; other site 1156913019026 G3 box; other site 1156913019027 G4 box; other site 1156913019028 G5 box; other site 1156913019029 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1156913019030 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1156913019031 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1156913019032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913019033 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1156913019034 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1156913019035 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1156913019036 minor groove reading motif; other site 1156913019037 helix-hairpin-helix signature motif; other site 1156913019038 substrate binding pocket [chemical binding]; other site 1156913019039 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1156913019040 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1156913019041 DNA binding site [nucleotide binding] 1156913019042 active site 1156913019043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913019044 AAA domain; Region: AAA_23; pfam13476 1156913019045 Walker A/P-loop; other site 1156913019046 ATP binding site [chemical binding]; other site 1156913019047 Q-loop/lid; other site 1156913019048 ABC transporter signature motif; other site 1156913019049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913019050 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1156913019051 Walker B; other site 1156913019052 D-loop; other site 1156913019053 H-loop/switch region; other site 1156913019054 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1156913019055 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913019056 active site 1156913019057 metal binding site [ion binding]; metal-binding site 1156913019058 DNA binding site [nucleotide binding] 1156913019059 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1156913019060 RmuC family; Region: RmuC; pfam02646 1156913019061 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1156913019062 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1156913019063 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1156913019064 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1156913019065 generic binding surface II; other site 1156913019066 generic binding surface I; other site 1156913019067 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1156913019068 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1156913019069 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1156913019070 putative active site [active] 1156913019071 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1156913019072 active site 1156913019073 substrate binding sites [chemical binding]; other site 1156913019074 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1156913019075 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913019076 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1156913019077 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1156913019078 tetramer interface [polypeptide binding]; other site 1156913019079 EamA-like transporter family; Region: EamA; pfam00892 1156913019080 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1156913019081 EamA-like transporter family; Region: EamA; pfam00892 1156913019082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913019083 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913019084 salt bridge; other site 1156913019085 non-specific DNA binding site [nucleotide binding]; other site 1156913019086 sequence-specific DNA binding site [nucleotide binding]; other site 1156913019087 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1156913019088 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1156913019089 active site 1156913019090 DNA binding site [nucleotide binding] 1156913019091 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1156913019092 DNA binding site [nucleotide binding] 1156913019093 geranyl diphosphate synthase; Region: PLN02890 1156913019094 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1156913019095 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1156913019096 putative active site [active] 1156913019097 putative FMN binding site [chemical binding]; other site 1156913019098 putative substrate binding site [chemical binding]; other site 1156913019099 putative catalytic residue [active] 1156913019100 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1156913019101 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913019102 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913019103 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1156913019104 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1156913019105 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1156913019106 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1156913019107 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1156913019108 phosphate binding site [ion binding]; other site 1156913019109 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1156913019110 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1156913019111 active site 1156913019112 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1156913019113 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1156913019114 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1156913019115 putative active site [active] 1156913019116 PhoH-like protein; Region: PhoH; pfam02562 1156913019117 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1156913019118 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1156913019119 catalytic residue [active] 1156913019120 putative FPP diphosphate binding site; other site 1156913019121 putative FPP binding hydrophobic cleft; other site 1156913019122 dimer interface [polypeptide binding]; other site 1156913019123 putative IPP diphosphate binding site; other site 1156913019124 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1156913019125 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1156913019126 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 1156913019127 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1156913019128 Ion channel; Region: Ion_trans_2; pfam07885 1156913019129 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913019130 acyl-coenzyme A oxidase; Region: PLN02636 1156913019131 active site 1156913019132 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1156913019133 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1156913019134 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1156913019135 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1156913019136 catalytic residues [active] 1156913019137 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1156913019138 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1156913019139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913019140 S-adenosylmethionine binding site [chemical binding]; other site 1156913019141 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1156913019142 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1156913019143 active site 1156913019144 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1156913019145 active site 1156913019146 metal binding site [ion binding]; metal-binding site 1156913019147 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1156913019148 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1156913019149 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1156913019150 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1156913019151 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1156913019152 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913019153 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913019154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1156913019155 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913019156 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1156913019157 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1156913019158 dimer interface [polypeptide binding]; other site 1156913019159 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1156913019160 active site 1156913019161 Fe binding site [ion binding]; other site 1156913019162 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1156913019163 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1156913019164 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1156913019165 cystathionine gamma-synthase; Provisional; Region: PRK07811 1156913019166 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1156913019167 homodimer interface [polypeptide binding]; other site 1156913019168 substrate-cofactor binding pocket; other site 1156913019169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913019170 catalytic residue [active] 1156913019171 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1156913019172 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1156913019173 dimer interface [polypeptide binding]; other site 1156913019174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913019175 catalytic residue [active] 1156913019176 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1156913019177 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1156913019178 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1156913019179 dimer interface [polypeptide binding]; other site 1156913019180 active site 1156913019181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913019182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913019183 putative substrate translocation pore; other site 1156913019184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913019185 Sulphur transport; Region: Sulf_transp; pfam04143 1156913019186 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1156913019187 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1156913019188 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1156913019189 active site 1156913019190 putative catalytic site [active] 1156913019191 short chain dehydrogenase; Provisional; Region: PRK07201 1156913019192 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1156913019193 putative NAD(P) binding site [chemical binding]; other site 1156913019194 active site 1156913019195 putative substrate binding site [chemical binding]; other site 1156913019196 classical (c) SDRs; Region: SDR_c; cd05233 1156913019197 NAD(P) binding site [chemical binding]; other site 1156913019198 active site 1156913019199 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1156913019200 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1156913019201 Amidase; Region: Amidase; cl11426 1156913019202 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1156913019203 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1156913019204 FMN binding site [chemical binding]; other site 1156913019205 active site 1156913019206 substrate binding site [chemical binding]; other site 1156913019207 catalytic residue [active] 1156913019208 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1156913019209 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1156913019210 DNA binding residues [nucleotide binding] 1156913019211 putative dimer interface [polypeptide binding]; other site 1156913019212 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913019213 TIGR03086 family protein; Region: TIGR03086 1156913019214 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 1156913019215 putative hydrophobic ligand binding site [chemical binding]; other site 1156913019216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913019217 dimerization interface [polypeptide binding]; other site 1156913019218 putative DNA binding site [nucleotide binding]; other site 1156913019219 putative Zn2+ binding site [ion binding]; other site 1156913019220 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1156913019221 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1156913019222 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1156913019223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913019224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019225 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1156913019226 Cytochrome P450; Region: p450; cl12078 1156913019227 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913019228 catalytic core [active] 1156913019229 TIGR03084 family protein; Region: TIGR03084 1156913019230 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1156913019231 Wyosine base formation; Region: Wyosine_form; pfam08608 1156913019232 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1156913019233 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1156913019234 DNA binding residues [nucleotide binding] 1156913019235 dimer interface [polypeptide binding]; other site 1156913019236 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913019237 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1156913019238 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1156913019239 active site 1156913019240 Histidine kinase; Region: HisKA_3; pfam07730 1156913019241 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913019242 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913019243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913019244 active site 1156913019245 phosphorylation site [posttranslational modification] 1156913019246 intermolecular recognition site; other site 1156913019247 dimerization interface [polypeptide binding]; other site 1156913019248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913019249 DNA binding residues [nucleotide binding] 1156913019250 dimerization interface [polypeptide binding]; other site 1156913019251 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913019252 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1156913019253 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913019254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913019255 DNA binding site [nucleotide binding] 1156913019256 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1156913019257 Moco binding site; other site 1156913019258 metal coordination site [ion binding]; other site 1156913019259 dimerization interface [polypeptide binding]; other site 1156913019260 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913019261 Helix-turn-helix domain; Region: HTH_17; pfam12728 1156913019262 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1156913019263 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1156913019264 active site 1156913019265 DNA binding site [nucleotide binding] 1156913019266 Int/Topo IB signature motif; other site 1156913019267 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1156913019268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913019269 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1156913019270 Fe-S cluster binding site [ion binding]; other site 1156913019271 DNA binding site [nucleotide binding] 1156913019272 active site 1156913019273 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1156913019274 Active_site [active] 1156913019275 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1156913019276 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1156913019277 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1156913019278 active site 1156913019279 catalytic residues [active] 1156913019280 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1156913019281 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913019282 Walker A/P-loop; other site 1156913019283 ATP binding site [chemical binding]; other site 1156913019284 Q-loop/lid; other site 1156913019285 ABC transporter signature motif; other site 1156913019286 Walker B; other site 1156913019287 D-loop; other site 1156913019288 H-loop/switch region; other site 1156913019289 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1156913019290 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1156913019291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913019292 Walker A/P-loop; other site 1156913019293 ATP binding site [chemical binding]; other site 1156913019294 Q-loop/lid; other site 1156913019295 ABC transporter signature motif; other site 1156913019296 Walker B; other site 1156913019297 D-loop; other site 1156913019298 H-loop/switch region; other site 1156913019299 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1156913019300 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1156913019301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913019302 dimer interface [polypeptide binding]; other site 1156913019303 conserved gate region; other site 1156913019304 putative PBP binding loops; other site 1156913019305 ABC-ATPase subunit interface; other site 1156913019306 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1156913019307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913019308 dimer interface [polypeptide binding]; other site 1156913019309 conserved gate region; other site 1156913019310 putative PBP binding loops; other site 1156913019311 ABC-ATPase subunit interface; other site 1156913019312 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1156913019313 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1156913019314 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1156913019315 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1156913019316 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1156913019317 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1156913019318 catalytic residue [active] 1156913019319 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1156913019320 Septum formation initiator; Region: DivIC; pfam04977 1156913019321 enolase; Provisional; Region: eno; PRK00077 1156913019322 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1156913019323 dimer interface [polypeptide binding]; other site 1156913019324 metal binding site [ion binding]; metal-binding site 1156913019325 substrate binding pocket [chemical binding]; other site 1156913019326 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1156913019327 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913019328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1156913019329 binding surface 1156913019330 TPR motif; other site 1156913019331 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1156913019332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913019333 non-specific DNA binding site [nucleotide binding]; other site 1156913019334 salt bridge; other site 1156913019335 sequence-specific DNA binding site [nucleotide binding]; other site 1156913019336 Cupin domain; Region: Cupin_2; pfam07883 1156913019337 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1156913019338 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1156913019339 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 1156913019340 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1156913019341 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1156913019342 Walker A/P-loop; other site 1156913019343 ATP binding site [chemical binding]; other site 1156913019344 Q-loop/lid; other site 1156913019345 ABC transporter signature motif; other site 1156913019346 Walker B; other site 1156913019347 D-loop; other site 1156913019348 H-loop/switch region; other site 1156913019349 Putative zinc-finger; Region: zf-HC2; pfam13490 1156913019350 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913019351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913019352 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1156913019353 DNA binding residues [nucleotide binding] 1156913019354 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1156913019355 homodimer interface [polypeptide binding]; other site 1156913019356 MazG family protein; Region: mazG; TIGR00444 1156913019357 metal binding site [ion binding]; metal-binding site 1156913019358 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1156913019359 SurA N-terminal domain; Region: SurA_N_3; cl07813 1156913019360 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1156913019361 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1156913019362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913019363 ATP binding site [chemical binding]; other site 1156913019364 putative Mg++ binding site [ion binding]; other site 1156913019365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913019366 nucleotide binding region [chemical binding]; other site 1156913019367 ATP-binding site [chemical binding]; other site 1156913019368 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1156913019369 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1156913019370 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913019371 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913019372 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913019373 non-specific DNA binding site [nucleotide binding]; other site 1156913019374 salt bridge; other site 1156913019375 sequence-specific DNA binding site [nucleotide binding]; other site 1156913019376 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1156913019377 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1156913019378 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1156913019379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913019380 S-adenosylmethionine binding site [chemical binding]; other site 1156913019381 Histidine kinase; Region: HisKA_3; pfam07730 1156913019382 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913019383 ATP binding site [chemical binding]; other site 1156913019384 Mg2+ binding site [ion binding]; other site 1156913019385 G-X-G motif; other site 1156913019386 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913019387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913019388 active site 1156913019389 phosphorylation site [posttranslational modification] 1156913019390 intermolecular recognition site; other site 1156913019391 dimerization interface [polypeptide binding]; other site 1156913019392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913019393 DNA binding residues [nucleotide binding] 1156913019394 dimerization interface [polypeptide binding]; other site 1156913019395 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1156913019396 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1156913019397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913019398 Isochorismatase family; Region: Isochorismatase; pfam00857 1156913019399 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1156913019400 catalytic triad [active] 1156913019401 conserved cis-peptide bond; other site 1156913019402 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1156913019403 nudix motif; other site 1156913019404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913019405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019406 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1156913019407 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1156913019408 Di-iron ligands [ion binding]; other site 1156913019409 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1156913019410 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913019411 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913019412 metal binding site [ion binding]; metal-binding site 1156913019413 active site 1156913019414 I-site; other site 1156913019415 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1156913019416 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1156913019417 Substrate binding site; other site 1156913019418 Mg++ binding site; other site 1156913019419 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1156913019420 active site 1156913019421 substrate binding site [chemical binding]; other site 1156913019422 CoA binding site [chemical binding]; other site 1156913019423 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1156913019424 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1156913019425 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1156913019426 active site 1156913019427 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1156913019428 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913019429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913019430 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1156913019431 NAD(P) binding site [chemical binding]; other site 1156913019432 active site 1156913019433 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1156913019434 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1156913019435 5S rRNA interface [nucleotide binding]; other site 1156913019436 CTC domain interface [polypeptide binding]; other site 1156913019437 L16 interface [polypeptide binding]; other site 1156913019438 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1156913019439 putative active site [active] 1156913019440 catalytic residue [active] 1156913019441 DivIVA domain; Region: DivI1A_domain; TIGR03544 1156913019442 DivIVA domain; Region: DivI1A_domain; TIGR03544 1156913019443 DivIVA domain; Region: DivI1A_domain; TIGR03544 1156913019444 DivIVA domain; Region: DivI1A_domain; TIGR03544 1156913019445 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1156913019446 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1156913019447 acyl-activating enzyme (AAE) consensus motif; other site 1156913019448 active site 1156913019449 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1156913019450 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913019451 ABC transporter; Region: ABC_tran_2; pfam12848 1156913019452 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1156913019453 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1156913019454 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1156913019455 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1156913019456 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1156913019457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913019458 Walker A/P-loop; other site 1156913019459 ATP binding site [chemical binding]; other site 1156913019460 Q-loop/lid; other site 1156913019461 ABC transporter signature motif; other site 1156913019462 Walker B; other site 1156913019463 D-loop; other site 1156913019464 H-loop/switch region; other site 1156913019465 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1156913019466 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1156913019467 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1156913019468 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1156913019469 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1156913019470 G5 domain; Region: G5; pfam07501 1156913019471 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1156913019472 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1156913019473 active site 1156913019474 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1156913019475 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1156913019476 active site 1156913019477 HIGH motif; other site 1156913019478 KMSKS motif; other site 1156913019479 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1156913019480 tRNA binding surface [nucleotide binding]; other site 1156913019481 anticodon binding site; other site 1156913019482 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913019483 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1156913019484 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913019485 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1156913019486 Walker A/P-loop; other site 1156913019487 ATP binding site [chemical binding]; other site 1156913019488 Q-loop/lid; other site 1156913019489 ABC transporter signature motif; other site 1156913019490 Walker B; other site 1156913019491 D-loop; other site 1156913019492 H-loop/switch region; other site 1156913019493 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1156913019494 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1156913019495 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1156913019496 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1156913019497 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1156913019498 active site 1156913019499 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1156913019500 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1156913019501 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913019502 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1156913019503 NAD(P) binding site [chemical binding]; other site 1156913019504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019505 Predicted methyltransferases [General function prediction only]; Region: COG0313 1156913019506 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1156913019507 putative SAM binding site [chemical binding]; other site 1156913019508 putative homodimer interface [polypeptide binding]; other site 1156913019509 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1156913019510 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1156913019511 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913019512 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913019513 active site 1156913019514 ATP binding site [chemical binding]; other site 1156913019515 substrate binding site [chemical binding]; other site 1156913019516 activation loop (A-loop); other site 1156913019517 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1156913019518 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1156913019519 acyl-activating enzyme (AAE) consensus motif; other site 1156913019520 putative AMP binding site [chemical binding]; other site 1156913019521 putative active site [active] 1156913019522 putative CoA binding site [chemical binding]; other site 1156913019523 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1156913019524 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 1156913019525 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1156913019526 active site 1156913019527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913019528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1156913019530 MOSC domain; Region: MOSC; pfam03473 1156913019531 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913019532 TIGR03086 family protein; Region: TIGR03086 1156913019533 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1156913019534 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1156913019535 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913019536 NAD(P) binding site [chemical binding]; other site 1156913019537 catalytic residues [active] 1156913019538 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913019539 DNA binding site [nucleotide binding] 1156913019540 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1156913019541 active site 1156913019542 catalytic triad [active] 1156913019543 oxyanion hole [active] 1156913019544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913019545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019546 WHG domain; Region: WHG; pfam13305 1156913019547 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1156913019548 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1156913019549 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1156913019550 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913019551 putative DNA binding site [nucleotide binding]; other site 1156913019552 putative Zn2+ binding site [ion binding]; other site 1156913019553 MMPL family; Region: MMPL; pfam03176 1156913019554 MMPL family; Region: MMPL; pfam03176 1156913019555 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1156913019556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913019557 S-adenosylmethionine binding site [chemical binding]; other site 1156913019558 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 1156913019559 active site 1156913019560 substrate binding site; other site 1156913019561 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1156913019562 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1156913019563 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1156913019564 dimer interface [polypeptide binding]; other site 1156913019565 putative functional site; other site 1156913019566 putative MPT binding site; other site 1156913019567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1156913019568 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1156913019569 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1156913019570 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913019571 active site 1156913019572 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913019573 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1156913019574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913019575 putative substrate translocation pore; other site 1156913019576 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913019577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913019578 non-specific DNA binding site [nucleotide binding]; other site 1156913019579 salt bridge; other site 1156913019580 sequence-specific DNA binding site [nucleotide binding]; other site 1156913019581 Cupin domain; Region: Cupin_2; pfam07883 1156913019582 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1156913019583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913019584 tyrosine decarboxylase; Region: PLN02880 1156913019585 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1156913019586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913019587 catalytic residue [active] 1156913019588 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1156913019589 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1156913019590 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1156913019591 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1156913019592 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1156913019593 MPT binding site; other site 1156913019594 trimer interface [polypeptide binding]; other site 1156913019595 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1156913019596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913019597 NAD(P) binding site [chemical binding]; other site 1156913019598 active site 1156913019599 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913019600 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913019601 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913019602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913019603 dimer interface [polypeptide binding]; other site 1156913019604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913019605 phosphorylation site [posttranslational modification] 1156913019606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913019607 ATP binding site [chemical binding]; other site 1156913019608 Mg2+ binding site [ion binding]; other site 1156913019609 G-X-G motif; other site 1156913019610 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913019611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913019612 active site 1156913019613 phosphorylation site [posttranslational modification] 1156913019614 intermolecular recognition site; other site 1156913019615 dimerization interface [polypeptide binding]; other site 1156913019616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913019617 DNA binding site [nucleotide binding] 1156913019618 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1156913019619 Ligand binding site; other site 1156913019620 Putative Catalytic site; other site 1156913019621 DXD motif; other site 1156913019622 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1156913019623 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913019624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913019625 S-adenosylmethionine binding site [chemical binding]; other site 1156913019626 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1156913019627 Moco binding site; other site 1156913019628 metal coordination site [ion binding]; other site 1156913019629 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1156913019630 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1156913019631 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1156913019632 protein binding site [polypeptide binding]; other site 1156913019633 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1156913019634 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1156913019635 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1156913019636 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1156913019637 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1156913019638 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1156913019639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913019640 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913019641 dimerization interface [polypeptide binding]; other site 1156913019642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913019643 dimer interface [polypeptide binding]; other site 1156913019644 phosphorylation site [posttranslational modification] 1156913019645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913019646 ATP binding site [chemical binding]; other site 1156913019647 Mg2+ binding site [ion binding]; other site 1156913019648 G-X-G motif; other site 1156913019649 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913019650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913019651 active site 1156913019652 phosphorylation site [posttranslational modification] 1156913019653 intermolecular recognition site; other site 1156913019654 dimerization interface [polypeptide binding]; other site 1156913019655 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913019656 DNA binding site [nucleotide binding] 1156913019657 Predicted membrane protein [Function unknown]; Region: COG2860 1156913019658 UPF0126 domain; Region: UPF0126; pfam03458 1156913019659 UPF0126 domain; Region: UPF0126; pfam03458 1156913019660 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913019661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913019662 active site 1156913019663 phosphorylation site [posttranslational modification] 1156913019664 intermolecular recognition site; other site 1156913019665 dimerization interface [polypeptide binding]; other site 1156913019666 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913019667 DNA binding residues [nucleotide binding] 1156913019668 dimerization interface [polypeptide binding]; other site 1156913019669 wnt family; Region: wnt; pfam00110 1156913019670 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1156913019671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913019672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019673 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1156913019674 MOSC domain; Region: MOSC; pfam03473 1156913019675 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1156913019676 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913019677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913019678 non-specific DNA binding site [nucleotide binding]; other site 1156913019679 salt bridge; other site 1156913019680 sequence-specific DNA binding site [nucleotide binding]; other site 1156913019681 TIGR02677 family protein; Region: TIGR02677 1156913019682 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 1156913019683 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 1156913019684 TIGR02680 family protein; Region: TIGR02680 1156913019685 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1156913019686 DNA binding site [nucleotide binding] 1156913019687 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913019688 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913019689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1156913019690 TPR motif; other site 1156913019691 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913019692 binding surface 1156913019693 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913019694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1156913019695 binding surface 1156913019696 TPR motif; other site 1156913019697 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 1156913019698 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1156913019699 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1156913019700 active site 1156913019701 Predicted membrane protein [Function unknown]; Region: COG4270 1156913019702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019703 WHG domain; Region: WHG; pfam13305 1156913019704 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1156913019705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913019706 NAD(P) binding site [chemical binding]; other site 1156913019707 active site 1156913019708 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1156913019709 cleavage site 1156913019710 active site 1156913019711 substrate binding sites [chemical binding]; other site 1156913019712 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1156913019713 YCII-related domain; Region: YCII; cl00999 1156913019714 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1156913019715 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913019716 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1156913019717 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1156913019718 DNA binding residues [nucleotide binding] 1156913019719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913019720 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1156913019721 NAD(P) binding site [chemical binding]; other site 1156913019722 active site 1156913019723 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1156913019724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913019725 S-adenosylmethionine binding site [chemical binding]; other site 1156913019726 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1156913019727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913019728 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1156913019729 putative dimerization interface [polypeptide binding]; other site 1156913019730 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1156913019731 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913019732 Berberine and berberine like; Region: BBE; pfam08031 1156913019733 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1156913019734 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1156913019735 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1156913019736 PaaX-like protein; Region: PaaX; pfam07848 1156913019737 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1156913019738 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1156913019739 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1156913019740 homotrimer interaction site [polypeptide binding]; other site 1156913019741 putative active site [active] 1156913019742 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 1156913019743 hypothetical protein; Provisional; Region: PRK07236 1156913019744 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1156913019745 active site 1156913019746 FMN binding site [chemical binding]; other site 1156913019747 substrate binding site [chemical binding]; other site 1156913019748 homotetramer interface [polypeptide binding]; other site 1156913019749 catalytic residue [active] 1156913019750 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913019751 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913019752 active site 1156913019753 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 1156913019754 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1156913019755 beta-galactosidase; Region: BGL; TIGR03356 1156913019756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1156913019757 dimerization interface [polypeptide binding]; other site 1156913019758 putative DNA binding site [nucleotide binding]; other site 1156913019759 putative Zn2+ binding site [ion binding]; other site 1156913019760 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913019761 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913019762 nucleotide binding site [chemical binding]; other site 1156913019763 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913019764 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1156913019765 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1156913019766 active site 1156913019767 catalytic residues [active] 1156913019768 Ricin-type beta-trefoil; Region: RICIN; smart00458 1156913019769 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1156913019770 putative sugar binding sites [chemical binding]; other site 1156913019771 Q-X-W motif; other site 1156913019772 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1156913019773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913019774 DNA-binding site [nucleotide binding]; DNA binding site 1156913019775 FCD domain; Region: FCD; pfam07729 1156913019776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913019777 putative substrate translocation pore; other site 1156913019778 hypothetical protein; Provisional; Region: PRK05463 1156913019779 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1156913019780 putative active site [active] 1156913019781 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1156913019782 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1156913019783 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1156913019784 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1156913019785 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1156913019786 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1156913019787 putative NAD(P) binding site [chemical binding]; other site 1156913019788 catalytic Zn binding site [ion binding]; other site 1156913019789 structural Zn binding site [ion binding]; other site 1156913019790 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1156913019791 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1156913019792 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1156913019793 FeoA domain; Region: FeoA; pfam04023 1156913019794 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1156913019795 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1156913019796 active site 1156913019797 enoyl-CoA hydratase; Provisional; Region: PRK09245 1156913019798 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913019799 substrate binding site [chemical binding]; other site 1156913019800 oxyanion hole (OAH) forming residues; other site 1156913019801 trimer interface [polypeptide binding]; other site 1156913019802 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1156913019803 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1156913019804 acyl-activating enzyme (AAE) consensus motif; other site 1156913019805 putative AMP binding site [chemical binding]; other site 1156913019806 putative active site [active] 1156913019807 putative CoA binding site [chemical binding]; other site 1156913019808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913019809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019810 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1156913019811 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913019812 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913019813 active site 1156913019814 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1156913019815 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1156913019816 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1156913019817 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1156913019818 isochorismate synthase DhbC; Validated; Region: PRK06923 1156913019819 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1156913019820 flavoprotein, HI0933 family; Region: TIGR00275 1156913019821 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1156913019822 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1156913019823 dimer interface [polypeptide binding]; other site 1156913019824 acyl-activating enzyme (AAE) consensus motif; other site 1156913019825 putative active site [active] 1156913019826 AMP binding site [chemical binding]; other site 1156913019827 putative CoA binding site [chemical binding]; other site 1156913019828 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1156913019829 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1156913019830 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1156913019831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019832 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913019833 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 1156913019834 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1156913019835 putative active site [active] 1156913019836 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1156913019837 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1156913019838 NAD binding site [chemical binding]; other site 1156913019839 catalytic Zn binding site [ion binding]; other site 1156913019840 substrate binding site [chemical binding]; other site 1156913019841 structural Zn binding site [ion binding]; other site 1156913019842 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1156913019843 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913019844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913019845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019846 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1156913019847 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913019848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913019849 salt bridge; other site 1156913019850 non-specific DNA binding site [nucleotide binding]; other site 1156913019851 sequence-specific DNA binding site [nucleotide binding]; other site 1156913019852 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1156913019853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913019854 Walker A/P-loop; other site 1156913019855 ATP binding site [chemical binding]; other site 1156913019856 Q-loop/lid; other site 1156913019857 ABC transporter signature motif; other site 1156913019858 Walker B; other site 1156913019859 D-loop; other site 1156913019860 H-loop/switch region; other site 1156913019861 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1156913019862 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1156913019863 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1156913019864 DNA photolyase; Region: DNA_photolyase; pfam00875 1156913019865 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1156913019866 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1156913019867 dimer interface [polypeptide binding]; other site 1156913019868 active site 1156913019869 citrylCoA binding site [chemical binding]; other site 1156913019870 NADH binding [chemical binding]; other site 1156913019871 cationic pore residues; other site 1156913019872 oxalacetate/citrate binding site [chemical binding]; other site 1156913019873 coenzyme A binding site [chemical binding]; other site 1156913019874 catalytic triad [active] 1156913019875 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1156913019876 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1156913019877 putative substrate binding site [chemical binding]; other site 1156913019878 putative ATP binding site [chemical binding]; other site 1156913019879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913019880 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1156913019881 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1156913019882 active site 1156913019883 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1156913019884 putative active site [active] 1156913019885 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1156913019886 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1156913019887 active site 1156913019888 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1156913019889 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1156913019890 active site 1156913019891 catalytic residues [active] 1156913019892 acyl-CoA synthetase; Validated; Region: PRK08316 1156913019893 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913019894 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1156913019895 acyl-activating enzyme (AAE) consensus motif; other site 1156913019896 acyl-activating enzyme (AAE) consensus motif; other site 1156913019897 putative AMP binding site [chemical binding]; other site 1156913019898 putative active site [active] 1156913019899 putative CoA binding site [chemical binding]; other site 1156913019900 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1156913019901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913019902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913019904 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913019905 amino acid transporter; Region: 2A0306; TIGR00909 1156913019906 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913019907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913019908 putative substrate translocation pore; other site 1156913019909 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1156913019910 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1156913019911 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1156913019912 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1156913019913 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1156913019914 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1156913019915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913019916 dimer interface [polypeptide binding]; other site 1156913019917 conserved gate region; other site 1156913019918 ABC-ATPase subunit interface; other site 1156913019919 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1156913019920 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1156913019921 Walker A/P-loop; other site 1156913019922 ATP binding site [chemical binding]; other site 1156913019923 Q-loop/lid; other site 1156913019924 ABC transporter signature motif; other site 1156913019925 Walker B; other site 1156913019926 D-loop; other site 1156913019927 H-loop/switch region; other site 1156913019928 Nitrate and nitrite sensing; Region: NIT; pfam08376 1156913019929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913019930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913019931 ATP binding site [chemical binding]; other site 1156913019932 Mg2+ binding site [ion binding]; other site 1156913019933 G-X-G motif; other site 1156913019934 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1156913019935 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1156913019936 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1156913019937 G2 box; other site 1156913019938 Switch I region; other site 1156913019939 G3 box; other site 1156913019940 Switch II region; other site 1156913019941 GTP/Mg2+ binding site [chemical binding]; other site 1156913019942 G4 box; other site 1156913019943 G5 box; other site 1156913019944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913019945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019946 Secretory lipase; Region: LIP; pfam03583 1156913019947 UreD urease accessory protein; Region: UreD; cl00530 1156913019948 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1156913019949 AAA domain; Region: AAA_18; pfam13238 1156913019950 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1156913019951 UreF; Region: UreF; pfam01730 1156913019952 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1156913019953 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1156913019954 subunit interactions [polypeptide binding]; other site 1156913019955 active site 1156913019956 flap region; other site 1156913019957 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1156913019958 gamma-beta subunit interface [polypeptide binding]; other site 1156913019959 alpha-beta subunit interface [polypeptide binding]; other site 1156913019960 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1156913019961 alpha-gamma subunit interface [polypeptide binding]; other site 1156913019962 beta-gamma subunit interface [polypeptide binding]; other site 1156913019963 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1156913019964 dimer interface [polypeptide binding]; other site 1156913019965 Citrate synthase; Region: Citrate_synt; pfam00285 1156913019966 active site 1156913019967 citrylCoA binding site [chemical binding]; other site 1156913019968 oxalacetate/citrate binding site [chemical binding]; other site 1156913019969 coenzyme A binding site [chemical binding]; other site 1156913019970 catalytic triad [active] 1156913019971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913019972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913019973 short chain dehydrogenase; Validated; Region: PRK05855 1156913019974 classical (c) SDRs; Region: SDR_c; cd05233 1156913019975 NAD(P) binding site [chemical binding]; other site 1156913019976 active site 1156913019977 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913019978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913019979 putative substrate translocation pore; other site 1156913019980 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1156913019981 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1156913019982 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913019983 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1156913019984 Walker A/P-loop; other site 1156913019985 ATP binding site [chemical binding]; other site 1156913019986 Q-loop/lid; other site 1156913019987 ABC transporter signature motif; other site 1156913019988 Walker B; other site 1156913019989 D-loop; other site 1156913019990 H-loop/switch region; other site 1156913019991 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1156913019992 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1156913019993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913019994 Histidine kinase; Region: HisKA_3; pfam07730 1156913019995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913019996 ATP binding site [chemical binding]; other site 1156913019997 Mg2+ binding site [ion binding]; other site 1156913019998 G-X-G motif; other site 1156913019999 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913020000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913020001 active site 1156913020002 phosphorylation site [posttranslational modification] 1156913020003 intermolecular recognition site; other site 1156913020004 dimerization interface [polypeptide binding]; other site 1156913020005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913020006 DNA binding residues [nucleotide binding] 1156913020007 dimerization interface [polypeptide binding]; other site 1156913020008 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913020009 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913020010 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1156913020011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913020012 catalytic residue [active] 1156913020013 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1156913020014 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1156913020015 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1156913020016 FtsX-like permease family; Region: FtsX; pfam02687 1156913020017 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913020018 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1156913020019 Walker A/P-loop; other site 1156913020020 ATP binding site [chemical binding]; other site 1156913020021 Q-loop/lid; other site 1156913020022 ABC transporter signature motif; other site 1156913020023 Walker B; other site 1156913020024 D-loop; other site 1156913020025 H-loop/switch region; other site 1156913020026 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1156913020027 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913020028 Orthopoxvirus A26L/A30L protein; Region: Pox_A30L_A26L; cl17524 1156913020029 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 1156913020030 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1156913020031 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1156913020032 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913020033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913020034 active site 1156913020035 phosphorylation site [posttranslational modification] 1156913020036 intermolecular recognition site; other site 1156913020037 dimerization interface [polypeptide binding]; other site 1156913020038 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913020039 DNA binding site [nucleotide binding] 1156913020040 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1156913020041 dimerization interface [polypeptide binding]; other site 1156913020042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913020043 dimer interface [polypeptide binding]; other site 1156913020044 phosphorylation site [posttranslational modification] 1156913020045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913020046 ATP binding site [chemical binding]; other site 1156913020047 Mg2+ binding site [ion binding]; other site 1156913020048 G-X-G motif; other site 1156913020049 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1156913020050 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1156913020051 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1156913020052 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1156913020053 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1156913020054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913020055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913020056 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1156913020057 heme binding pocket [chemical binding]; other site 1156913020058 heme ligand [chemical binding]; other site 1156913020059 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1156913020060 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1156913020061 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1156913020062 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1156913020063 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913020064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913020065 putative substrate translocation pore; other site 1156913020066 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913020067 MarR family; Region: MarR; pfam01047 1156913020068 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1156913020069 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 1156913020070 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1156913020071 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1156913020072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913020073 putative substrate translocation pore; other site 1156913020074 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1156913020075 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1156913020076 DNA-binding site [nucleotide binding]; DNA binding site 1156913020077 RNA-binding motif; other site 1156913020078 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1156913020079 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1156913020080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913020081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913020082 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1156913020083 active site 1156913020084 diiron metal binding site [ion binding]; other site 1156913020085 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1156913020086 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1156913020087 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1156913020088 AMP-binding domain protein; Validated; Region: PRK08315 1156913020089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913020090 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1156913020091 acyl-activating enzyme (AAE) consensus motif; other site 1156913020092 acyl-activating enzyme (AAE) consensus motif; other site 1156913020093 putative AMP binding site [chemical binding]; other site 1156913020094 putative active site [active] 1156913020095 putative CoA binding site [chemical binding]; other site 1156913020096 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1156913020097 hypothetical protein; Provisional; Region: PRK11770 1156913020098 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1156913020099 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1156913020100 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1156913020101 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1156913020102 active site 1156913020103 metal binding site [ion binding]; metal-binding site 1156913020104 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1156913020105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913020106 active site 1156913020107 motif I; other site 1156913020108 motif II; other site 1156913020109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913020110 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1156913020111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913020112 Walker A/P-loop; other site 1156913020113 ATP binding site [chemical binding]; other site 1156913020114 Q-loop/lid; other site 1156913020115 ABC transporter signature motif; other site 1156913020116 Walker B; other site 1156913020117 D-loop; other site 1156913020118 H-loop/switch region; other site 1156913020119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913020120 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1156913020121 putative PBP binding loops; other site 1156913020122 ABC-ATPase subunit interface; other site 1156913020123 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1156913020124 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1156913020125 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1156913020126 DNA binding residues [nucleotide binding] 1156913020127 TOBE domain; Region: TOBE; cl01440 1156913020128 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913020129 MarR family; Region: MarR; pfam01047 1156913020130 MarR family; Region: MarR_2; cl17246 1156913020131 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1156913020132 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1156913020133 FeS/SAM binding site; other site 1156913020134 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1156913020135 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1156913020136 MoaE interaction surface [polypeptide binding]; other site 1156913020137 MoeB interaction surface [polypeptide binding]; other site 1156913020138 thiocarboxylated glycine; other site 1156913020139 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 1156913020140 putative active site [active] 1156913020141 catalytic site [active] 1156913020142 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1156913020143 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1156913020144 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1156913020145 MoaE homodimer interface [polypeptide binding]; other site 1156913020146 MoaD interaction [polypeptide binding]; other site 1156913020147 active site residues [active] 1156913020148 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1156913020149 MPT binding site; other site 1156913020150 trimer interface [polypeptide binding]; other site 1156913020151 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1156913020152 trimer interface [polypeptide binding]; other site 1156913020153 dimer interface [polypeptide binding]; other site 1156913020154 putative active site [active] 1156913020155 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913020156 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913020157 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1156913020158 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1156913020159 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1156913020160 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1156913020161 NAD(P) binding pocket [chemical binding]; other site 1156913020162 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1156913020163 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1156913020164 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1156913020165 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1156913020166 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1156913020167 G1 box; other site 1156913020168 GTP/Mg2+ binding site [chemical binding]; other site 1156913020169 G2 box; other site 1156913020170 Switch I region; other site 1156913020171 G3 box; other site 1156913020172 Switch II region; other site 1156913020173 G4 box; other site 1156913020174 G5 box; other site 1156913020175 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1156913020176 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1156913020177 Nitrate and nitrite sensing; Region: NIT; pfam08376 1156913020178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913020179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913020180 ATP binding site [chemical binding]; other site 1156913020181 Mg2+ binding site [ion binding]; other site 1156913020182 G-X-G motif; other site 1156913020183 NMT1-like family; Region: NMT1_2; pfam13379 1156913020184 NMT1/THI5 like; Region: NMT1; pfam09084 1156913020185 substrate binding pocket [chemical binding]; other site 1156913020186 membrane-bound complex binding site; other site 1156913020187 hinge residues; other site 1156913020188 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1156913020189 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1156913020190 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1156913020191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913020192 putative PBP binding loops; other site 1156913020193 ABC-ATPase subunit interface; other site 1156913020194 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1156913020195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1156913020196 dimer interface [polypeptide binding]; other site 1156913020197 conserved gate region; other site 1156913020198 ABC-ATPase subunit interface; other site 1156913020199 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1156913020200 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1156913020201 Walker A/P-loop; other site 1156913020202 ATP binding site [chemical binding]; other site 1156913020203 Q-loop/lid; other site 1156913020204 ABC transporter signature motif; other site 1156913020205 Walker B; other site 1156913020206 D-loop; other site 1156913020207 H-loop/switch region; other site 1156913020208 benzoylformate decarboxylase; Reviewed; Region: PRK07092 1156913020209 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1156913020210 PYR/PP interface [polypeptide binding]; other site 1156913020211 dimer interface [polypeptide binding]; other site 1156913020212 TPP binding site [chemical binding]; other site 1156913020213 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1156913020214 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1156913020215 TPP-binding site [chemical binding]; other site 1156913020216 dimer interface [polypeptide binding]; other site 1156913020217 CutC family; Region: CutC; cl01218 1156913020218 Nitrate and nitrite sensing; Region: NIT; pfam08376 1156913020219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1156913020220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913020221 ATP binding site [chemical binding]; other site 1156913020222 Mg2+ binding site [ion binding]; other site 1156913020223 G-X-G motif; other site 1156913020224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1156913020225 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1156913020226 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1156913020227 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1156913020228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1156913020229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913020230 ATP binding site [chemical binding]; other site 1156913020231 putative Mg++ binding site [ion binding]; other site 1156913020232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913020233 nucleotide binding region [chemical binding]; other site 1156913020234 ATP-binding site [chemical binding]; other site 1156913020235 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 1156913020236 Protein of unknown function DUF72; Region: DUF72; pfam01904 1156913020237 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1156913020238 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913020239 NB-ARC domain; Region: NB-ARC; pfam00931 1156913020240 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913020241 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913020242 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1156913020243 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1156913020244 active site 1156913020245 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1156913020246 Peptidase family M23; Region: Peptidase_M23; pfam01551 1156913020247 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1156913020248 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913020249 substrate binding pocket [chemical binding]; other site 1156913020250 membrane-bound complex binding site; other site 1156913020251 hinge residues; other site 1156913020252 PspC domain; Region: PspC; pfam04024 1156913020253 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1156913020254 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1156913020255 ring oligomerisation interface [polypeptide binding]; other site 1156913020256 ATP/Mg binding site [chemical binding]; other site 1156913020257 stacking interactions; other site 1156913020258 hinge regions; other site 1156913020259 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1156913020260 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913020261 active site 1156913020262 ATP binding site [chemical binding]; other site 1156913020263 substrate binding site [chemical binding]; other site 1156913020264 activation loop (A-loop); other site 1156913020265 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1156913020266 DNA-binding site [nucleotide binding]; DNA binding site 1156913020267 RNA-binding motif; other site 1156913020268 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1156913020269 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1156913020270 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1156913020271 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1156913020272 dimer interface [polypeptide binding]; other site 1156913020273 putative functional site; other site 1156913020274 putative MPT binding site; other site 1156913020275 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913020276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913020277 putative DNA binding site [nucleotide binding]; other site 1156913020278 putative Zn2+ binding site [ion binding]; other site 1156913020279 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1156913020280 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1156913020281 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1156913020282 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1156913020283 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1156913020284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913020285 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913020286 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1156913020287 FMN binding site [chemical binding]; other site 1156913020288 dimer interface [polypeptide binding]; other site 1156913020289 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1156913020290 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1156913020291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913020292 Walker A motif; other site 1156913020293 ATP binding site [chemical binding]; other site 1156913020294 Walker B motif; other site 1156913020295 arginine finger; other site 1156913020296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913020297 Walker A motif; other site 1156913020298 ATP binding site [chemical binding]; other site 1156913020299 Walker B motif; other site 1156913020300 arginine finger; other site 1156913020301 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1156913020302 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1156913020303 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1156913020304 active site 1156913020305 catalytic residues [active] 1156913020306 metal binding site [ion binding]; metal-binding site 1156913020307 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 1156913020308 Domain interface; other site 1156913020309 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 1156913020310 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1156913020311 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1156913020312 ThiC-associated domain; Region: ThiC-associated; pfam13667 1156913020313 ThiC family; Region: ThiC; pfam01964 1156913020314 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1156913020315 dimer interface [polypeptide binding]; other site 1156913020316 substrate binding site [chemical binding]; other site 1156913020317 ATP binding site [chemical binding]; other site 1156913020318 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1156913020319 Predicted transcriptional regulators [Transcription]; Region: COG1733 1156913020320 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1156913020321 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1156913020322 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1156913020323 putative NAD(P) binding site [chemical binding]; other site 1156913020324 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1156913020325 substrate binding site [chemical binding]; other site 1156913020326 dimer interface [polypeptide binding]; other site 1156913020327 ATP binding site [chemical binding]; other site 1156913020328 Ion transport protein; Region: Ion_trans; pfam00520 1156913020329 MarR family; Region: MarR; pfam01047 1156913020330 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1156913020331 ThiS interaction site; other site 1156913020332 putative active site [active] 1156913020333 tetramer interface [polypeptide binding]; other site 1156913020334 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1156913020335 thiS-thiF/thiG interaction site; other site 1156913020336 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1156913020337 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1156913020338 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1156913020339 thiamine phosphate binding site [chemical binding]; other site 1156913020340 active site 1156913020341 pyrophosphate binding site [ion binding]; other site 1156913020342 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1156913020343 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1156913020344 tetramer interface [polypeptide binding]; other site 1156913020345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913020346 catalytic residue [active] 1156913020347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913020348 putative substrate translocation pore; other site 1156913020349 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1156913020350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1156913020351 DNA-binding site [nucleotide binding]; DNA binding site 1156913020352 UTRA domain; Region: UTRA; pfam07702 1156913020353 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1156913020354 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1156913020355 dimer interface [polypeptide binding]; other site 1156913020356 active site 1156913020357 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1156913020358 dimer interface [polypeptide binding]; other site 1156913020359 active site 1156913020360 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1156913020361 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1156913020362 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1156913020363 active site 1156913020364 catalytic triad [active] 1156913020365 oxyanion hole [active] 1156913020366 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1156913020367 ligand binding site [chemical binding]; other site 1156913020368 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 1156913020369 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1156913020370 DNA binding site [nucleotide binding] 1156913020371 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913020372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1156913020373 TPR motif; other site 1156913020374 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913020375 binding surface 1156913020376 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1156913020377 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1156913020378 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 1156913020379 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1156913020380 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1156913020381 inhibitor-cofactor binding pocket; inhibition site 1156913020382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913020383 catalytic residue [active] 1156913020384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913020385 Coenzyme A binding pocket [chemical binding]; other site 1156913020386 patatin-related protein; Region: TIGR03607 1156913020387 Patatin-like phospholipase; Region: Patatin; pfam01734 1156913020388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1156913020389 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 1156913020390 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913020391 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1156913020392 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1156913020393 Cupin; Region: Cupin_6; pfam12852 1156913020394 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1156913020395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913020396 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1156913020397 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1156913020398 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1156913020399 active site 1156913020400 dimer interface [polypeptide binding]; other site 1156913020401 Predicted esterase [General function prediction only]; Region: COG0400 1156913020402 putative hydrolase; Provisional; Region: PRK11460 1156913020403 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1156913020404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913020405 Zn binding site [ion binding]; other site 1156913020406 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1156913020407 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913020408 Zn binding site [ion binding]; other site 1156913020409 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913020410 MarR family; Region: MarR_2; pfam12802 1156913020411 MarR family; Region: MarR_2; cl17246 1156913020412 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 1156913020413 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1156913020414 acyl-activating enzyme (AAE) consensus motif; other site 1156913020415 AMP binding site [chemical binding]; other site 1156913020416 active site 1156913020417 CoA binding site [chemical binding]; other site 1156913020418 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 1156913020419 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 1156913020420 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1156913020421 substrate binding site [chemical binding]; other site 1156913020422 oxyanion hole (OAH) forming residues; other site 1156913020423 trimer interface [polypeptide binding]; other site 1156913020424 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1156913020425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913020426 Walker A/P-loop; other site 1156913020427 ATP binding site [chemical binding]; other site 1156913020428 Q-loop/lid; other site 1156913020429 ABC transporter signature motif; other site 1156913020430 Walker B; other site 1156913020431 D-loop; other site 1156913020432 H-loop/switch region; other site 1156913020433 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913020434 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1156913020435 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913020436 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1156913020437 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1156913020438 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1156913020439 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1156913020440 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1156913020441 Bacterial transcriptional regulator; Region: IclR; pfam01614 1156913020442 L-lactate permease; Region: Lactate_perm; cl00701 1156913020443 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1156913020444 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1156913020445 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1156913020446 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913020447 DNA binding residues [nucleotide binding] 1156913020448 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1156913020449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913020450 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1156913020451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1156913020452 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 1156913020453 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1156913020454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913020455 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 1156913020456 putative dimerization interface [polypeptide binding]; other site 1156913020457 putative substrate binding pocket [chemical binding]; other site 1156913020458 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1156913020459 GAF domain; Region: GAF; pfam01590 1156913020460 ANTAR domain; Region: ANTAR; pfam03861 1156913020461 GAF domain; Region: GAF; cl17456 1156913020462 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913020463 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913020464 DNA binding residues [nucleotide binding] 1156913020465 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 1156913020466 substrate binding pocket [chemical binding]; other site 1156913020467 catalytic residues [active] 1156913020468 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1156913020469 substrate binding pocket [chemical binding]; other site 1156913020470 substrate-Mg2+ binding site; other site 1156913020471 aspartate-rich region 1; other site 1156913020472 aspartate-rich region 2; other site 1156913020473 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1156913020474 substrate binding pocket [chemical binding]; other site 1156913020475 substrate-Mg2+ binding site; other site 1156913020476 aspartate-rich region 1; other site 1156913020477 aspartate-rich region 2; other site 1156913020478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913020479 dimerization interface [polypeptide binding]; other site 1156913020480 putative DNA binding site [nucleotide binding]; other site 1156913020481 putative Zn2+ binding site [ion binding]; other site 1156913020482 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1156913020483 putative hydrophobic ligand binding site [chemical binding]; other site 1156913020484 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913020485 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1156913020486 PhoD-like phosphatase; Region: PhoD; pfam09423 1156913020487 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1156913020488 putative active site [active] 1156913020489 putative metal binding site [ion binding]; other site 1156913020490 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1156913020491 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1156913020492 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1156913020493 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1156913020494 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1156913020495 active site 1156913020496 homotetramer interface [polypeptide binding]; other site 1156913020497 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1156913020498 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1156913020499 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1156913020500 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1156913020501 Molybdopterin converting factor, small subunit [Coenzyme metabolism]; Region: MoaD; COG1977 1156913020502 charged pocket; other site 1156913020503 hydrophobic patch; other site 1156913020504 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1156913020505 Asp-box motif; other site 1156913020506 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1156913020507 Asp-box motif; other site 1156913020508 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1156913020509 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1156913020510 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1156913020511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913020512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1156913020513 DNA repair protein RadA; Provisional; Region: PRK11823 1156913020514 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1156913020515 Walker A motif/ATP binding site; other site 1156913020516 ATP binding site [chemical binding]; other site 1156913020517 Walker B motif; other site 1156913020518 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1156913020519 Protein of unknown function (DUF461); Region: DUF461; cl01071 1156913020520 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1156913020521 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1156913020522 active site 1156913020523 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1156913020524 homotrimer interaction site [polypeptide binding]; other site 1156913020525 zinc binding site [ion binding]; other site 1156913020526 CDP-binding sites; other site 1156913020527 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1156913020528 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1156913020529 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1156913020530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913020531 motif II; other site 1156913020532 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1156913020533 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1156913020534 active site 1156913020535 HIGH motif; other site 1156913020536 nucleotide binding site [chemical binding]; other site 1156913020537 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1156913020538 KMSKS motif; other site 1156913020539 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1156913020540 tRNA binding surface [nucleotide binding]; other site 1156913020541 anticodon binding site; other site 1156913020542 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1156913020543 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1156913020544 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1156913020545 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1156913020546 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913020547 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1156913020548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913020549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913020550 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1156913020551 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1156913020552 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1156913020553 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1156913020554 intersubunit interface [polypeptide binding]; other site 1156913020555 active site 1156913020556 Zn2+ binding site [ion binding]; other site 1156913020557 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1156913020558 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1156913020559 putative N- and C-terminal domain interface [polypeptide binding]; other site 1156913020560 putative active site [active] 1156913020561 MgATP binding site [chemical binding]; other site 1156913020562 catalytic site [active] 1156913020563 metal binding site [ion binding]; metal-binding site 1156913020564 putative xylulose binding site [chemical binding]; other site 1156913020565 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1156913020566 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1156913020567 putative ligand binding site [chemical binding]; other site 1156913020568 putative NAD binding site [chemical binding]; other site 1156913020569 catalytic site [active] 1156913020570 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1156913020571 dihydroxyacetone kinase; Provisional; Region: PRK14479 1156913020572 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1156913020573 DAK2 domain; Region: Dak2; pfam02734 1156913020574 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1156913020575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913020576 motif II; other site 1156913020577 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1156913020578 catalytic core [active] 1156913020579 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1156913020580 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1156913020581 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1156913020582 polyol permease family; Region: 2A0118; TIGR00897 1156913020583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913020584 putative substrate translocation pore; other site 1156913020585 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913020586 D-xylulose kinase; Region: XylB; TIGR01312 1156913020587 nucleotide binding site [chemical binding]; other site 1156913020588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1156913020589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1156913020590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1156913020591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1156913020592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1156913020593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1156913020594 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913020595 dimer interface [polypeptide binding]; other site 1156913020596 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1156913020597 putative PBP binding regions; other site 1156913020598 ABC-ATPase subunit interface; other site 1156913020599 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1156913020600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913020601 Walker A/P-loop; other site 1156913020602 ATP binding site [chemical binding]; other site 1156913020603 Q-loop/lid; other site 1156913020604 ABC transporter signature motif; other site 1156913020605 Walker B; other site 1156913020606 D-loop; other site 1156913020607 H-loop/switch region; other site 1156913020608 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1156913020609 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1156913020610 intersubunit interface [polypeptide binding]; other site 1156913020611 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913020612 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913020613 DNA binding site [nucleotide binding] 1156913020614 domain linker motif; other site 1156913020615 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1156913020616 putative dimerization interface [polypeptide binding]; other site 1156913020617 putative ligand binding site [chemical binding]; other site 1156913020618 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1156913020619 active site clefts [active] 1156913020620 zinc binding site [ion binding]; other site 1156913020621 dimer interface [polypeptide binding]; other site 1156913020622 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1156913020623 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1156913020624 minor groove reading motif; other site 1156913020625 helix-hairpin-helix signature motif; other site 1156913020626 active site 1156913020627 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1156913020628 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1156913020629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913020630 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1156913020631 Peptidase family M1; Region: Peptidase_M1; pfam01433 1156913020632 Zn binding site [ion binding]; other site 1156913020633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913020634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913020635 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1156913020636 dimerization interface [polypeptide binding]; other site 1156913020637 substrate binding pocket [chemical binding]; other site 1156913020638 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1156913020639 Na binding site [ion binding]; other site 1156913020640 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1156913020641 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1156913020642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913020643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1156913020644 dimerization interface [polypeptide binding]; other site 1156913020645 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1156913020646 active site residue [active] 1156913020647 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1156913020648 catalytic residues [active] 1156913020649 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913020650 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1156913020651 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1156913020652 Zn binding site [ion binding]; other site 1156913020653 hypothetical protein; Validated; Region: PRK05868 1156913020654 hypothetical protein; Provisional; Region: PRK07236 1156913020655 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1156913020656 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1156913020657 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1156913020658 putative catalytic site [active] 1156913020659 putative metal binding site [ion binding]; other site 1156913020660 putative phosphate binding site [ion binding]; other site 1156913020661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913020662 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1156913020663 Walker A/P-loop; other site 1156913020664 ATP binding site [chemical binding]; other site 1156913020665 Q-loop/lid; other site 1156913020666 ABC transporter signature motif; other site 1156913020667 Walker B; other site 1156913020668 D-loop; other site 1156913020669 H-loop/switch region; other site 1156913020670 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1156913020671 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1156913020672 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1156913020673 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1156913020674 AAA ATPase domain; Region: AAA_16; pfam13191 1156913020675 Predicted ATPase [General function prediction only]; Region: COG3903 1156913020676 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1156913020677 Zn binding site [ion binding]; other site 1156913020678 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1156913020679 putative substrate binding pocket [chemical binding]; other site 1156913020680 AC domain interface; other site 1156913020681 catalytic triad [active] 1156913020682 AB domain interface; other site 1156913020683 interchain disulfide; other site 1156913020684 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1156913020685 nucleotide binding site [chemical binding]; other site 1156913020686 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1156913020687 SBD interface [polypeptide binding]; other site 1156913020688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913020689 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1156913020690 non-specific DNA binding site [nucleotide binding]; other site 1156913020691 salt bridge; other site 1156913020692 sequence-specific DNA binding site [nucleotide binding]; other site 1156913020693 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1156913020694 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1156913020695 Clp amino terminal domain; Region: Clp_N; pfam02861 1156913020696 Clp amino terminal domain; Region: Clp_N; pfam02861 1156913020697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913020698 Walker A motif; other site 1156913020699 ATP binding site [chemical binding]; other site 1156913020700 Walker B motif; other site 1156913020701 arginine finger; other site 1156913020702 UvrB/uvrC motif; Region: UVR; pfam02151 1156913020703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913020704 Walker A motif; other site 1156913020705 ATP binding site [chemical binding]; other site 1156913020706 Walker B motif; other site 1156913020707 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1156913020708 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1156913020709 TIGR03086 family protein; Region: TIGR03086 1156913020710 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1156913020711 Helix-turn-helix domain; Region: HTH_18; pfam12833 1156913020712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1156913020713 Lsr2; Region: Lsr2; pfam11774 1156913020714 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1156913020715 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1156913020716 dimer interface [polypeptide binding]; other site 1156913020717 putative anticodon binding site; other site 1156913020718 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1156913020719 motif 1; other site 1156913020720 dimer interface [polypeptide binding]; other site 1156913020721 active site 1156913020722 motif 2; other site 1156913020723 motif 3; other site 1156913020724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913020725 S-adenosylmethionine binding site [chemical binding]; other site 1156913020726 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913020727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913020728 S-adenosylmethionine binding site [chemical binding]; other site 1156913020729 pantothenate kinase; Reviewed; Region: PRK13318 1156913020730 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1156913020731 tetramerization interface [polypeptide binding]; other site 1156913020732 active site 1156913020733 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1156913020734 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1156913020735 active site 1156913020736 ATP-binding site [chemical binding]; other site 1156913020737 pantoate-binding site; other site 1156913020738 HXXH motif; other site 1156913020739 Rossmann-like domain; Region: Rossmann-like; pfam10727 1156913020740 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1156913020741 Protease prsW family; Region: PrsW-protease; pfam13367 1156913020742 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1156913020743 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1156913020744 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913020745 DNA binding residues [nucleotide binding] 1156913020746 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1156913020747 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1156913020748 catalytic center binding site [active] 1156913020749 ATP binding site [chemical binding]; other site 1156913020750 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1156913020751 homooctamer interface [polypeptide binding]; other site 1156913020752 active site 1156913020753 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1156913020754 dihydropteroate synthase; Region: DHPS; TIGR01496 1156913020755 substrate binding pocket [chemical binding]; other site 1156913020756 dimer interface [polypeptide binding]; other site 1156913020757 inhibitor binding site; inhibition site 1156913020758 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1156913020759 homodecamer interface [polypeptide binding]; other site 1156913020760 GTP cyclohydrolase I; Provisional; Region: PLN03044 1156913020761 active site 1156913020762 putative catalytic site residues [active] 1156913020763 zinc binding site [ion binding]; other site 1156913020764 GTP-CH-I/GFRP interaction surface; other site 1156913020765 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1156913020766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913020767 Walker A motif; other site 1156913020768 ATP binding site [chemical binding]; other site 1156913020769 Walker B motif; other site 1156913020770 arginine finger; other site 1156913020771 Peptidase family M41; Region: Peptidase_M41; pfam01434 1156913020772 EspG family; Region: ESX-1_EspG; pfam14011 1156913020773 EspG family; Region: ESX-1_EspG; pfam14011 1156913020774 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1156913020775 active site 1156913020776 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1156913020777 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1156913020778 Ligand Binding Site [chemical binding]; other site 1156913020779 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1156913020780 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1156913020781 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1156913020782 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1156913020783 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1156913020784 dimer interface [polypeptide binding]; other site 1156913020785 substrate binding site [chemical binding]; other site 1156913020786 metal binding sites [ion binding]; metal-binding site 1156913020787 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1156913020788 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1156913020789 dimer interface [polypeptide binding]; other site 1156913020790 active site 1156913020791 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1156913020792 folate binding site [chemical binding]; other site 1156913020793 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1156913020794 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1156913020795 putative thiostrepton binding site; other site 1156913020796 23S rRNA interface [nucleotide binding]; other site 1156913020797 L7/L12 interface [polypeptide binding]; other site 1156913020798 L25 interface [polypeptide binding]; other site 1156913020799 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1156913020800 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1156913020801 trimer interface [polypeptide binding]; other site 1156913020802 putative metal binding site [ion binding]; other site 1156913020803 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 1156913020804 putative active site [active] 1156913020805 Zn binding site [ion binding]; other site 1156913020806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913020807 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1156913020808 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1156913020809 PBP superfamily domain; Region: PBP_like_2; cl17296 1156913020810 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1156913020811 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1156913020812 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1156913020813 classical (c) SDRs; Region: SDR_c; cd05233 1156913020814 NAD(P) binding site [chemical binding]; other site 1156913020815 short chain dehydrogenase; Provisional; Region: PRK05650 1156913020816 active site 1156913020817 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1156913020818 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1156913020819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913020820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913020821 HNH endonuclease; Region: HNH_2; pfam13391 1156913020822 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1156913020823 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1156913020824 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1156913020825 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1156913020826 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1156913020827 polymerase nucleotide-binding site; other site 1156913020828 DNA-binding residues [nucleotide binding]; DNA binding site 1156913020829 nucleotide binding site [chemical binding]; other site 1156913020830 primase nucleotide-binding site [nucleotide binding]; other site 1156913020831 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1156913020832 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1156913020833 cofactor binding site; other site 1156913020834 DNA binding site [nucleotide binding] 1156913020835 substrate interaction site [chemical binding]; other site 1156913020836 AAA domain; Region: AAA_25; pfam13481 1156913020837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913020838 putative DNA binding site [nucleotide binding]; other site 1156913020839 putative Zn2+ binding site [ion binding]; other site 1156913020840 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1156913020841 active site 1156913020842 DNA binding site [nucleotide binding] 1156913020843 Int/Topo IB signature motif; other site 1156913020844 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1156913020845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913020846 Walker A motif; other site 1156913020847 ATP binding site [chemical binding]; other site 1156913020848 Walker B motif; other site 1156913020849 arginine finger; other site 1156913020850 thymidylate kinase; Validated; Region: tmk; PRK00698 1156913020851 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1156913020852 TMP-binding site; other site 1156913020853 ATP-binding site [chemical binding]; other site 1156913020854 EspG family; Region: ESX-1_EspG; pfam14011 1156913020855 EspG family; Region: ESX-1_EspG; pfam14011 1156913020856 transcriptional regulator BetI; Validated; Region: PRK00767 1156913020857 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1156913020858 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1156913020859 active site 1156913020860 interdomain interaction site; other site 1156913020861 putative metal-binding site [ion binding]; other site 1156913020862 nucleotide binding site [chemical binding]; other site 1156913020863 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1156913020864 domain I; other site 1156913020865 phosphate binding site [ion binding]; other site 1156913020866 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1156913020867 domain II; other site 1156913020868 domain III; other site 1156913020869 nucleotide binding site [chemical binding]; other site 1156913020870 DNA binding groove [nucleotide binding] 1156913020871 catalytic site [active] 1156913020872 domain IV; other site 1156913020873 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1156913020874 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1156913020875 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1156913020876 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1156913020877 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1156913020878 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1156913020879 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1156913020880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1156913020881 ATP binding site [chemical binding]; other site 1156913020882 putative Mg++ binding site [ion binding]; other site 1156913020883 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1156913020884 nucleotide binding region [chemical binding]; other site 1156913020885 ATP-binding site [chemical binding]; other site 1156913020886 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1156913020887 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 1156913020888 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1156913020889 Type II/IV secretion system protein; Region: T2SE; pfam00437 1156913020890 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1156913020891 ATP binding site [chemical binding]; other site 1156913020892 Walker A motif; other site 1156913020893 hexamer interface [polypeptide binding]; other site 1156913020894 Walker B motif; other site 1156913020895 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1156913020896 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1156913020897 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1156913020898 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1156913020899 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1156913020900 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1156913020901 Beta-lactamase; Region: Beta-lactamase; cl17358 1156913020902 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913020903 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1156913020904 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1156913020905 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1156913020906 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1156913020907 putative active site [active] 1156913020908 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1156913020909 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1156913020910 putative active site [active] 1156913020911 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1156913020912 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1156913020913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913020914 putative substrate translocation pore; other site 1156913020915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913020916 dimerization interface [polypeptide binding]; other site 1156913020917 putative DNA binding site [nucleotide binding]; other site 1156913020918 putative Zn2+ binding site [ion binding]; other site 1156913020919 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1156913020920 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913020921 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1156913020922 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 1156913020923 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1156913020924 putative FMN binding site [chemical binding]; other site 1156913020925 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1156913020926 GAF domain; Region: GAF; pfam01590 1156913020927 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1156913020928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913020929 metabolite-proton symporter; Region: 2A0106; TIGR00883 1156913020930 putative substrate translocation pore; other site 1156913020931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913020932 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1156913020933 NAD(P) binding site [chemical binding]; other site 1156913020934 active site 1156913020935 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1156913020936 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1156913020937 active site 1156913020938 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1156913020939 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913020940 acetyl-CoA synthetase; Provisional; Region: PRK00174 1156913020941 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1156913020942 active site 1156913020943 CoA binding site [chemical binding]; other site 1156913020944 acyl-activating enzyme (AAE) consensus motif; other site 1156913020945 AMP binding site [chemical binding]; other site 1156913020946 acetate binding site [chemical binding]; other site 1156913020947 Cupin domain; Region: Cupin_2; pfam07883 1156913020948 metabolite-proton symporter; Region: 2A0106; TIGR00883 1156913020949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913020950 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 1156913020951 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 1156913020952 Thg1 C terminal domain; Region: Thg1C; pfam14413 1156913020953 AAA domain; Region: AAA_33; pfam13671 1156913020954 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1156913020955 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1156913020956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913020957 putative substrate translocation pore; other site 1156913020958 POT family; Region: PTR2; cl17359 1156913020959 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1156913020960 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1156913020961 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913020962 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913020963 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1156913020964 Colicin V production protein; Region: Colicin_V; pfam02674 1156913020965 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1156913020966 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1156913020967 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1156913020968 putative active site [active] 1156913020969 putative CoA binding site [chemical binding]; other site 1156913020970 nudix motif; other site 1156913020971 metal binding site [ion binding]; metal-binding site 1156913020972 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1156913020973 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1156913020974 catalytic residues [active] 1156913020975 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1156913020976 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1156913020977 minor groove reading motif; other site 1156913020978 helix-hairpin-helix signature motif; other site 1156913020979 substrate binding pocket [chemical binding]; other site 1156913020980 active site 1156913020981 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1156913020982 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1156913020983 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1156913020984 ligand binding site [chemical binding]; other site 1156913020985 flexible hinge region; other site 1156913020986 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1156913020987 putative switch regulator; other site 1156913020988 non-specific DNA interactions [nucleotide binding]; other site 1156913020989 DNA binding site [nucleotide binding] 1156913020990 sequence specific DNA binding site [nucleotide binding]; other site 1156913020991 putative cAMP binding site [chemical binding]; other site 1156913020992 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 1156913020993 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1156913020994 putative DNA binding surface [nucleotide binding]; other site 1156913020995 dimer interface [polypeptide binding]; other site 1156913020996 beta-clamp/clamp loader binding surface; other site 1156913020997 beta-clamp/translesion DNA polymerase binding surface; other site 1156913020998 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1156913020999 catalytic residues [active] 1156913021000 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1156913021001 NUDIX domain; Region: NUDIX; pfam00293 1156913021002 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1156913021003 homotrimer interaction site [polypeptide binding]; other site 1156913021004 putative active site [active] 1156913021005 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1156913021006 Lipase (class 2); Region: Lipase_2; pfam01674 1156913021007 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1156913021008 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1156913021009 DTAP/Switch II; other site 1156913021010 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1156913021011 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1156913021012 P loop; other site 1156913021013 Nucleotide binding site [chemical binding]; other site 1156913021014 DTAP/Switch II; other site 1156913021015 Switch I; other site 1156913021016 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1156913021017 Transcription factor WhiB; Region: Whib; pfam02467 1156913021018 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1156913021019 Transglycosylase; Region: Transgly; pfam00912 1156913021020 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1156913021021 phosphodiesterase YaeI; Provisional; Region: PRK11340 1156913021022 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1156913021023 putative active site [active] 1156913021024 putative metal binding site [ion binding]; other site 1156913021025 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1156913021026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913021027 S-adenosylmethionine binding site [chemical binding]; other site 1156913021028 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1156913021029 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913021030 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913021031 Tautomerase enzyme; Region: Tautomerase; pfam01361 1156913021032 active site 1 [active] 1156913021033 dimer interface [polypeptide binding]; other site 1156913021034 hexamer interface [polypeptide binding]; other site 1156913021035 active site 2 [active] 1156913021036 TIGR03085 family protein; Region: TIGR03085 1156913021037 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1156913021038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913021039 catalytic residue [active] 1156913021040 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1156913021041 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1156913021042 dimerization interface [polypeptide binding]; other site 1156913021043 DPS ferroxidase diiron center [ion binding]; other site 1156913021044 ion pore; other site 1156913021045 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1156913021046 Predicted flavoprotein [General function prediction only]; Region: COG0431 1156913021047 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1156913021048 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1156913021049 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1156913021050 substrate binding pocket [chemical binding]; other site 1156913021051 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1156913021052 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1156913021053 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1156913021054 tetramer interface [polypeptide binding]; other site 1156913021055 heme binding pocket [chemical binding]; other site 1156913021056 NADPH binding site [chemical binding]; other site 1156913021057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913021058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913021059 putative substrate translocation pore; other site 1156913021060 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1156913021061 hypothetical protein; Reviewed; Region: PRK09588 1156913021062 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1156913021063 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1156913021064 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1156913021065 aspartate kinase; Reviewed; Region: PRK06635 1156913021066 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1156913021067 putative nucleotide binding site [chemical binding]; other site 1156913021068 putative catalytic residues [active] 1156913021069 putative Mg ion binding site [ion binding]; other site 1156913021070 putative aspartate binding site [chemical binding]; other site 1156913021071 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1156913021072 putative allosteric regulatory site; other site 1156913021073 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1156913021074 putative allosteric regulatory residue; other site 1156913021075 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1156913021076 putative FMN binding site [chemical binding]; other site 1156913021077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913021078 putative substrate translocation pore; other site 1156913021079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913021080 salt bridge; other site 1156913021081 non-specific DNA binding site [nucleotide binding]; other site 1156913021082 sequence-specific DNA binding site [nucleotide binding]; other site 1156913021083 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1156913021084 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1156913021085 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1156913021086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913021087 S-adenosylmethionine binding site [chemical binding]; other site 1156913021088 PAS fold; Region: PAS; pfam00989 1156913021089 PAS domain; Region: PAS; smart00091 1156913021090 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1156913021091 CheB methylesterase; Region: CheB_methylest; pfam01339 1156913021092 2-isopropylmalate synthase; Validated; Region: PRK03739 1156913021093 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1156913021094 active site 1156913021095 catalytic residues [active] 1156913021096 metal binding site [ion binding]; metal-binding site 1156913021097 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1156913021098 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1156913021099 putative catalytic residues [active] 1156913021100 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913021101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913021102 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1156913021103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1156913021104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1156913021105 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1156913021106 putative dimerization interface [polypeptide binding]; other site 1156913021107 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1156913021108 EamA-like transporter family; Region: EamA; pfam00892 1156913021109 EamA-like transporter family; Region: EamA; pfam00892 1156913021110 short chain dehydrogenase; Validated; Region: PRK08264 1156913021111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913021112 NAD(P) binding site [chemical binding]; other site 1156913021113 active site 1156913021114 CGNR zinc finger; Region: zf-CGNR; pfam11706 1156913021115 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1156913021116 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1156913021117 NAD(P) binding site [chemical binding]; other site 1156913021118 putative active site [active] 1156913021119 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1156913021120 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913021121 Walker A/P-loop; other site 1156913021122 ATP binding site [chemical binding]; other site 1156913021123 Q-loop/lid; other site 1156913021124 ABC transporter signature motif; other site 1156913021125 Walker B; other site 1156913021126 D-loop; other site 1156913021127 H-loop/switch region; other site 1156913021128 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1156913021129 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1156913021130 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913021131 Walker A/P-loop; other site 1156913021132 ATP binding site [chemical binding]; other site 1156913021133 Q-loop/lid; other site 1156913021134 ABC transporter signature motif; other site 1156913021135 Walker B; other site 1156913021136 D-loop; other site 1156913021137 H-loop/switch region; other site 1156913021138 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1156913021139 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1156913021140 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1156913021141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913021142 dimer interface [polypeptide binding]; other site 1156913021143 conserved gate region; other site 1156913021144 putative PBP binding loops; other site 1156913021145 ABC-ATPase subunit interface; other site 1156913021146 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1156913021147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913021148 dimer interface [polypeptide binding]; other site 1156913021149 conserved gate region; other site 1156913021150 putative PBP binding loops; other site 1156913021151 ABC-ATPase subunit interface; other site 1156913021152 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1156913021153 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1156913021154 peptide binding site [polypeptide binding]; other site 1156913021155 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1156913021156 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1156913021157 Ligand binding site; other site 1156913021158 Putative Catalytic site; other site 1156913021159 DXD motif; other site 1156913021160 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1156913021161 active site 1156913021162 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1156913021163 recombination protein RecR; Reviewed; Region: recR; PRK00076 1156913021164 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1156913021165 RecR protein; Region: RecR; pfam02132 1156913021166 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1156913021167 putative active site [active] 1156913021168 putative metal-binding site [ion binding]; other site 1156913021169 tetramer interface [polypeptide binding]; other site 1156913021170 hypothetical protein; Validated; Region: PRK00153 1156913021171 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1156913021172 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1156913021173 active site 1156913021174 metal binding site [ion binding]; metal-binding site 1156913021175 Helix-turn-helix domain; Region: HTH_31; pfam13560 1156913021176 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1156913021177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913021178 putative DNA binding site [nucleotide binding]; other site 1156913021179 dimerization interface [polypeptide binding]; other site 1156913021180 putative Zn2+ binding site [ion binding]; other site 1156913021181 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1156913021182 putative phosphate binding site [ion binding]; other site 1156913021183 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1156913021184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913021185 Walker A motif; other site 1156913021186 ATP binding site [chemical binding]; other site 1156913021187 Walker B motif; other site 1156913021188 arginine finger; other site 1156913021189 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1156913021190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1156913021191 threonine dehydratase; Provisional; Region: PRK08246 1156913021192 hypothetical protein; Provisional; Region: PRK06815 1156913021193 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1156913021194 catalytic residue [active] 1156913021195 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1156913021196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1156913021197 dimer interface [polypeptide binding]; other site 1156913021198 phosphorylation site [posttranslational modification] 1156913021199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913021200 ATP binding site [chemical binding]; other site 1156913021201 Mg2+ binding site [ion binding]; other site 1156913021202 G-X-G motif; other site 1156913021203 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1156913021204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913021205 active site 1156913021206 phosphorylation site [posttranslational modification] 1156913021207 intermolecular recognition site; other site 1156913021208 dimerization interface [polypeptide binding]; other site 1156913021209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913021210 DNA binding site [nucleotide binding] 1156913021211 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1156913021212 AAA domain; Region: AAA_18; pfam13238 1156913021213 active site 1156913021214 Histidine kinase; Region: HisKA_3; pfam07730 1156913021215 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913021216 Mg2+ binding site [ion binding]; other site 1156913021217 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913021218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913021219 active site 1156913021220 phosphorylation site [posttranslational modification] 1156913021221 intermolecular recognition site; other site 1156913021222 dimerization interface [polypeptide binding]; other site 1156913021223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913021224 DNA binding residues [nucleotide binding] 1156913021225 dimerization interface [polypeptide binding]; other site 1156913021226 Domain of unknown function (DUF385); Region: DUF385; cl04387 1156913021227 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913021228 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913021229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913021230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913021231 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1156913021232 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 1156913021233 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1156913021234 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1156913021235 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1156913021236 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1156913021237 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1156913021238 LGFP repeat; Region: LGFP; pfam08310 1156913021239 LGFP repeat; Region: LGFP; pfam08310 1156913021240 LGFP repeat; Region: LGFP; pfam08310 1156913021241 LGFP repeat; Region: LGFP; pfam08310 1156913021242 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1156913021243 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 1156913021244 LGFP repeat; Region: LGFP; pfam08310 1156913021245 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1156913021246 LGFP repeat; Region: LGFP; pfam08310 1156913021247 LGFP repeat; Region: LGFP; pfam08310 1156913021248 LGFP repeat; Region: LGFP; pfam08310 1156913021249 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1156913021250 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1156913021251 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1156913021252 active site 1156913021253 ATP binding site [chemical binding]; other site 1156913021254 substrate binding site [chemical binding]; other site 1156913021255 activation loop (A-loop); other site 1156913021256 Helix-turn-helix domain; Region: HTH_17; pfam12728 1156913021257 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1156913021258 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 1156913021259 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1156913021260 active site 1156913021261 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1156913021262 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1156913021263 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 1156913021264 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1156913021265 generic binding surface I; other site 1156913021266 generic binding surface II; other site 1156913021267 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1156913021268 putative active site [active] 1156913021269 putative catalytic site [active] 1156913021270 putative Mg binding site IVb [ion binding]; other site 1156913021271 putative phosphate binding site [ion binding]; other site 1156913021272 putative DNA binding site [nucleotide binding]; other site 1156913021273 putative Mg binding site IVa [ion binding]; other site 1156913021274 BNR repeat-like domain; Region: BNR_2; pfam13088 1156913021275 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1156913021276 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1156913021277 CsbD-like; Region: CsbD; cl17424 1156913021278 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1156913021279 nucleoside/Zn binding site; other site 1156913021280 dimer interface [polypeptide binding]; other site 1156913021281 catalytic motif [active] 1156913021282 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1156913021283 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1156913021284 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1156913021285 metal binding site [ion binding]; metal-binding site 1156913021286 dimer interface [polypeptide binding]; other site 1156913021287 Domain of unknown function (DUF336); Region: DUF336; cl01249 1156913021288 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1156913021289 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1156913021290 inhibitor site; inhibition site 1156913021291 active site 1156913021292 dimer interface [polypeptide binding]; other site 1156913021293 catalytic residue [active] 1156913021294 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1156913021295 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1156913021296 active site 1156913021297 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1156913021298 substrate binding site [chemical binding]; other site 1156913021299 catalytic residues [active] 1156913021300 dimer interface [polypeptide binding]; other site 1156913021301 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913021302 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1156913021303 putative DNA binding site [nucleotide binding]; other site 1156913021304 putative Zn2+ binding site [ion binding]; other site 1156913021305 AsnC family; Region: AsnC_trans_reg; pfam01037 1156913021306 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1156913021307 Part of AAA domain; Region: AAA_19; pfam13245 1156913021308 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1156913021309 putative active site [active] 1156913021310 putative metal binding site [ion binding]; other site 1156913021311 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1156913021312 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1156913021313 EamA-like transporter family; Region: EamA; pfam00892 1156913021314 EamA-like transporter family; Region: EamA; pfam00892 1156913021315 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1156913021316 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 1156913021317 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1156913021318 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1156913021319 catalytic residue [active] 1156913021320 putative FPP diphosphate binding site; other site 1156913021321 putative FPP binding hydrophobic cleft; other site 1156913021322 dimer interface [polypeptide binding]; other site 1156913021323 putative IPP diphosphate binding site; other site 1156913021324 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1156913021325 AAA domain; Region: AAA_14; pfam13173 1156913021326 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1156913021327 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1156913021328 FMN binding site [chemical binding]; other site 1156913021329 active site 1156913021330 catalytic residues [active] 1156913021331 substrate binding site [chemical binding]; other site 1156913021332 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1156913021333 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913021334 isopentenyl-diphosphate delta-isomerase; Provisional; Region: PRK03759 1156913021335 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1156913021336 nudix motif; other site 1156913021337 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913021338 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913021339 metal binding site [ion binding]; metal-binding site 1156913021340 active site 1156913021341 I-site; other site 1156913021342 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1156913021343 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1156913021344 PhoU domain; Region: PhoU; pfam01895 1156913021345 PhoU domain; Region: PhoU; pfam01895 1156913021346 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1156913021347 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1156913021348 Walker A/P-loop; other site 1156913021349 ATP binding site [chemical binding]; other site 1156913021350 Q-loop/lid; other site 1156913021351 ABC transporter signature motif; other site 1156913021352 Walker B; other site 1156913021353 D-loop; other site 1156913021354 H-loop/switch region; other site 1156913021355 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1156913021356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913021357 dimer interface [polypeptide binding]; other site 1156913021358 conserved gate region; other site 1156913021359 putative PBP binding loops; other site 1156913021360 ABC-ATPase subunit interface; other site 1156913021361 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1156913021362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913021363 dimer interface [polypeptide binding]; other site 1156913021364 conserved gate region; other site 1156913021365 putative PBP binding loops; other site 1156913021366 ABC-ATPase subunit interface; other site 1156913021367 PBP superfamily domain; Region: PBP_like_2; cl17296 1156913021368 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1156913021369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913021370 Coenzyme A binding pocket [chemical binding]; other site 1156913021371 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913021372 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1156913021373 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1156913021374 DNA binding site [nucleotide binding] 1156913021375 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1156913021376 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1156913021377 catalytic residues [active] 1156913021378 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1156913021379 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1156913021380 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1156913021381 active site residue [active] 1156913021382 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1156913021383 active site residue [active] 1156913021384 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1156913021385 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1156913021386 heme-binding site [chemical binding]; other site 1156913021387 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1156913021388 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1156913021389 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1156913021390 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1156913021391 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1156913021392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913021393 catalytic residue [active] 1156913021394 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1156913021395 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1156913021396 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1156913021397 L-asparaginase II; Region: Asparaginase_II; pfam06089 1156913021398 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1156913021399 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1156913021400 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1156913021401 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1156913021402 PIN domain; Region: PIN_3; pfam13470 1156913021403 Helix-turn-helix domain; Region: HTH_17; cl17695 1156913021404 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1156913021405 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913021406 VanZ like family; Region: VanZ; pfam04892 1156913021407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913021408 Coenzyme A binding pocket [chemical binding]; other site 1156913021409 hypothetical protein; Provisional; Region: PRK09256 1156913021410 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1156913021411 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1156913021412 dimerization interface [polypeptide binding]; other site 1156913021413 putative ATP binding site [chemical binding]; other site 1156913021414 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1156913021415 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1156913021416 active site 1156913021417 tetramer interface [polypeptide binding]; other site 1156913021418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1156913021419 active site 1156913021420 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1156913021421 Helix-turn-helix domain; Region: HTH_31; pfam13560 1156913021422 non-specific DNA binding site [nucleotide binding]; other site 1156913021423 salt bridge; other site 1156913021424 sequence-specific DNA binding site [nucleotide binding]; other site 1156913021425 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1156913021426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1156913021427 S-adenosylmethionine binding site [chemical binding]; other site 1156913021428 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1156913021429 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1156913021430 active site 1156913021431 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 1156913021432 active site 1156913021433 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1156913021434 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1156913021435 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1156913021436 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1156913021437 dimerization interface [polypeptide binding]; other site 1156913021438 ATP binding site [chemical binding]; other site 1156913021439 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1156913021440 dimerization interface [polypeptide binding]; other site 1156913021441 ATP binding site [chemical binding]; other site 1156913021442 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1156913021443 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913021444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913021445 Walker A/P-loop; other site 1156913021446 ATP binding site [chemical binding]; other site 1156913021447 Q-loop/lid; other site 1156913021448 ABC transporter signature motif; other site 1156913021449 Walker B; other site 1156913021450 D-loop; other site 1156913021451 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913021452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913021453 Walker A/P-loop; other site 1156913021454 ATP binding site [chemical binding]; other site 1156913021455 Q-loop/lid; other site 1156913021456 ABC transporter signature motif; other site 1156913021457 Walker B; other site 1156913021458 D-loop; other site 1156913021459 H-loop/switch region; other site 1156913021460 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1156913021461 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1156913021462 putative active site [active] 1156913021463 catalytic triad [active] 1156913021464 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1156913021465 choline dehydrogenase; Validated; Region: PRK02106 1156913021466 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1156913021467 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1156913021468 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1156913021469 NAD(P) binding site [chemical binding]; other site 1156913021470 catalytic residues [active] 1156913021471 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913021472 putative DNA binding site [nucleotide binding]; other site 1156913021473 putative Zn2+ binding site [ion binding]; other site 1156913021474 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1156913021475 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1156913021476 Predicted membrane protein [Function unknown]; Region: COG2311 1156913021477 Protein of unknown function (DUF418); Region: DUF418; cl12135 1156913021478 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1156913021479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913021480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913021481 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913021482 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1156913021483 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1156913021484 ATP binding site [chemical binding]; other site 1156913021485 active site 1156913021486 substrate binding site [chemical binding]; other site 1156913021487 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1156913021488 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1156913021489 MOSC domain; Region: MOSC; pfam03473 1156913021490 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1156913021491 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1156913021492 Walker A/P-loop; other site 1156913021493 ATP binding site [chemical binding]; other site 1156913021494 Q-loop/lid; other site 1156913021495 ABC transporter signature motif; other site 1156913021496 Walker B; other site 1156913021497 D-loop; other site 1156913021498 H-loop/switch region; other site 1156913021499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913021500 dimer interface [polypeptide binding]; other site 1156913021501 conserved gate region; other site 1156913021502 putative PBP binding loops; other site 1156913021503 ABC-ATPase subunit interface; other site 1156913021504 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913021505 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1156913021506 substrate binding pocket [chemical binding]; other site 1156913021507 membrane-bound complex binding site; other site 1156913021508 hinge residues; other site 1156913021509 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1156913021510 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913021511 substrate binding pocket [chemical binding]; other site 1156913021512 membrane-bound complex binding site; other site 1156913021513 hinge residues; other site 1156913021514 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1156913021515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913021516 substrate binding pocket [chemical binding]; other site 1156913021517 membrane-bound complex binding site; other site 1156913021518 hinge residues; other site 1156913021519 adenylosuccinate lyase; Region: purB; TIGR00928 1156913021520 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1156913021521 tetramer interface [polypeptide binding]; other site 1156913021522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1156913021523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913021524 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1156913021525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913021526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913021527 DNA binding residues [nucleotide binding] 1156913021528 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1156913021529 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1156913021530 tetramer interface [polypeptide binding]; other site 1156913021531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913021532 catalytic residue [active] 1156913021533 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1156913021534 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913021535 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1156913021536 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1156913021537 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1156913021538 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1156913021539 catalytic residue [active] 1156913021540 EspG family; Region: ESX-1_EspG; pfam14011 1156913021541 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1156913021542 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1156913021543 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1156913021544 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1156913021545 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1156913021546 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1156913021547 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 1156913021548 putative active site [active] 1156913021549 catalytic site [active] 1156913021550 putative metal binding site [ion binding]; other site 1156913021551 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 1156913021552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913021553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1156913021554 putative substrate translocation pore; other site 1156913021555 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1156913021556 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1156913021557 OsmC-like protein; Region: OsmC; pfam02566 1156913021558 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1156913021559 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1156913021560 GDP-binding site [chemical binding]; other site 1156913021561 ACT binding site; other site 1156913021562 IMP binding site; other site 1156913021563 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1156913021564 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1156913021565 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1156913021566 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1156913021567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913021568 conserved gate region; other site 1156913021569 putative PBP binding loops; other site 1156913021570 ABC-ATPase subunit interface; other site 1156913021571 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1156913021572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913021573 putative PBP binding loops; other site 1156913021574 ABC-ATPase subunit interface; other site 1156913021575 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1156913021576 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913021577 Walker A/P-loop; other site 1156913021578 ATP binding site [chemical binding]; other site 1156913021579 Q-loop/lid; other site 1156913021580 ABC transporter signature motif; other site 1156913021581 Walker B; other site 1156913021582 D-loop; other site 1156913021583 H-loop/switch region; other site 1156913021584 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1156913021585 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1156913021586 Walker A/P-loop; other site 1156913021587 ATP binding site [chemical binding]; other site 1156913021588 Q-loop/lid; other site 1156913021589 ABC transporter signature motif; other site 1156913021590 Walker B; other site 1156913021591 D-loop; other site 1156913021592 H-loop/switch region; other site 1156913021593 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1156913021594 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1156913021595 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1156913021596 homodimer interface [polypeptide binding]; other site 1156913021597 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1156913021598 active site 1156913021599 TDP-binding site; other site 1156913021600 acceptor substrate-binding pocket; other site 1156913021601 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1156913021602 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1156913021603 active site 1156913021604 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1156913021605 dimer interface [polypeptide binding]; other site 1156913021606 non-prolyl cis peptide bond; other site 1156913021607 insertion regions; other site 1156913021608 H+ Antiporter protein; Region: 2A0121; TIGR00900 1156913021609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1156913021610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1156913021611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1156913021612 metal binding site [ion binding]; metal-binding site 1156913021613 active site 1156913021614 I-site; other site 1156913021615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913021616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913021617 Secretory lipase; Region: LIP; pfam03583 1156913021618 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1156913021619 AAA domain; Region: AAA_14; pfam13173 1156913021620 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1156913021621 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1156913021622 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1156913021623 active site 1156913021624 intersubunit interface [polypeptide binding]; other site 1156913021625 zinc binding site [ion binding]; other site 1156913021626 Na+ binding site [ion binding]; other site 1156913021627 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1156913021628 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1156913021629 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1156913021630 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1156913021631 active site 1156913021632 catalytic tetrad [active] 1156913021633 short chain dehydrogenase; Provisional; Region: PRK07825 1156913021634 classical (c) SDRs; Region: SDR_c; cd05233 1156913021635 NAD(P) binding site [chemical binding]; other site 1156913021636 active site 1156913021637 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1156913021638 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1156913021639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1156913021640 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1156913021641 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1156913021642 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1156913021643 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1156913021644 FMN-binding pocket [chemical binding]; other site 1156913021645 flavin binding motif; other site 1156913021646 phosphate binding motif [ion binding]; other site 1156913021647 beta-alpha-beta structure motif; other site 1156913021648 NAD binding pocket [chemical binding]; other site 1156913021649 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1156913021650 catalytic loop [active] 1156913021651 iron binding site [ion binding]; other site 1156913021652 YCII-related domain; Region: YCII; cl00999 1156913021653 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1156913021654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913021655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913021656 DNA binding residues [nucleotide binding] 1156913021657 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1156913021658 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1156913021659 active site 1156913021660 dimer interface [polypeptide binding]; other site 1156913021661 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1156913021662 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1156913021663 FAD binding domain; Region: FAD_binding_4; pfam01565 1156913021664 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1156913021665 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1156913021666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913021667 putative substrate translocation pore; other site 1156913021668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913021669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913021670 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1156913021671 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913021672 MarR family; Region: MarR; pfam01047 1156913021673 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1156913021674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913021675 putative substrate translocation pore; other site 1156913021676 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1156913021677 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1156913021678 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1156913021679 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1156913021680 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1156913021681 putative dimer interface [polypeptide binding]; other site 1156913021682 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913021683 ligand binding site [chemical binding]; other site 1156913021684 Zn binding site [ion binding]; other site 1156913021685 short chain dehydrogenase; Provisional; Region: PRK06123 1156913021686 classical (c) SDRs; Region: SDR_c; cd05233 1156913021687 NAD(P) binding site [chemical binding]; other site 1156913021688 active site 1156913021689 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1156913021690 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1156913021691 active site 1156913021692 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1156913021693 substrate binding site [chemical binding]; other site 1156913021694 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1156913021695 ATP binding site [chemical binding]; other site 1156913021696 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1156913021697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913021698 Walker A/P-loop; other site 1156913021699 ATP binding site [chemical binding]; other site 1156913021700 Q-loop/lid; other site 1156913021701 ABC transporter signature motif; other site 1156913021702 Walker B; other site 1156913021703 D-loop; other site 1156913021704 H-loop/switch region; other site 1156913021705 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1156913021706 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1156913021707 TM-ABC transporter signature motif; other site 1156913021708 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1156913021709 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1156913021710 ligand binding site [chemical binding]; other site 1156913021711 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1156913021712 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1156913021713 DNA binding site [nucleotide binding] 1156913021714 domain linker motif; other site 1156913021715 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1156913021716 ligand binding site [chemical binding]; other site 1156913021717 dimerization interface [polypeptide binding]; other site 1156913021718 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1156913021719 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1156913021720 ligand binding site [chemical binding]; other site 1156913021721 dimerization interface [polypeptide binding]; other site 1156913021722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913021723 Coenzyme A binding pocket [chemical binding]; other site 1156913021724 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1156913021725 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1156913021726 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1156913021727 putative [Fe4-S4] binding site [ion binding]; other site 1156913021728 putative molybdopterin cofactor binding site [chemical binding]; other site 1156913021729 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1156913021730 putative molybdopterin cofactor binding site; other site 1156913021731 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1156913021732 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1156913021733 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1156913021734 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1156913021735 active site 1156913021736 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1156913021737 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1156913021738 FtsX-like permease family; Region: FtsX; pfam02687 1156913021739 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913021740 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1156913021741 Walker A/P-loop; other site 1156913021742 ATP binding site [chemical binding]; other site 1156913021743 Q-loop/lid; other site 1156913021744 ABC transporter signature motif; other site 1156913021745 Walker B; other site 1156913021746 D-loop; other site 1156913021747 H-loop/switch region; other site 1156913021748 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1156913021749 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1156913021750 MgtC family; Region: MgtC; pfam02308 1156913021751 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1156913021752 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1156913021753 classical (c) SDRs; Region: SDR_c; cd05233 1156913021754 NAD(P) binding site [chemical binding]; other site 1156913021755 active site 1156913021756 anthranilate synthase; Provisional; Region: PRK13566 1156913021757 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1156913021758 Clp amino terminal domain; Region: Clp_N; pfam02861 1156913021759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913021760 Walker A motif; other site 1156913021761 ATP binding site [chemical binding]; other site 1156913021762 Walker B motif; other site 1156913021763 arginine finger; other site 1156913021764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1156913021765 Walker A motif; other site 1156913021766 ATP binding site [chemical binding]; other site 1156913021767 Walker B motif; other site 1156913021768 arginine finger; other site 1156913021769 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1156913021770 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913021771 MarR family; Region: MarR_2; pfam12802 1156913021772 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1156913021773 heme-binding site [chemical binding]; other site 1156913021774 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1156913021775 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1156913021776 FAD binding pocket [chemical binding]; other site 1156913021777 FAD binding motif [chemical binding]; other site 1156913021778 phosphate binding motif [ion binding]; other site 1156913021779 beta-alpha-beta structure motif; other site 1156913021780 NAD binding pocket [chemical binding]; other site 1156913021781 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1156913021782 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1156913021783 heme-binding site [chemical binding]; other site 1156913021784 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1156913021785 FAD binding pocket [chemical binding]; other site 1156913021786 FAD binding motif [chemical binding]; other site 1156913021787 phosphate binding motif [ion binding]; other site 1156913021788 beta-alpha-beta structure motif; other site 1156913021789 NAD binding pocket [chemical binding]; other site 1156913021790 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1156913021791 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1156913021792 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1156913021793 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1156913021794 DNA binding residues [nucleotide binding] 1156913021795 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913021796 putative dimer interface [polypeptide binding]; other site 1156913021797 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1156913021798 HSP70 interaction site [polypeptide binding]; other site 1156913021799 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1156913021800 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1156913021801 Zn binding sites [ion binding]; other site 1156913021802 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1156913021803 dimer interface [polypeptide binding]; other site 1156913021804 heat shock protein GrpE; Provisional; Region: PRK14140 1156913021805 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1156913021806 dimer interface [polypeptide binding]; other site 1156913021807 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1156913021808 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1156913021809 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1156913021810 nucleotide binding site [chemical binding]; other site 1156913021811 NEF interaction site [polypeptide binding]; other site 1156913021812 SBD interface [polypeptide binding]; other site 1156913021813 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1156913021814 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913021815 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1156913021816 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1156913021817 substrate binding site [chemical binding]; other site 1156913021818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913021819 Coenzyme A binding pocket [chemical binding]; other site 1156913021820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1156913021821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913021822 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1156913021823 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1156913021824 4Fe-4S binding domain; Region: Fer4; cl02805 1156913021825 4Fe-4S binding domain; Region: Fer4; pfam00037 1156913021826 Cysteine-rich domain; Region: CCG; pfam02754 1156913021827 Cysteine-rich domain; Region: CCG; pfam02754 1156913021828 Cation efflux family; Region: Cation_efflux; pfam01545 1156913021829 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1156913021830 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1156913021831 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913021832 MarR family; Region: MarR; pfam01047 1156913021833 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1156913021834 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1156913021835 trimer interface [polypeptide binding]; other site 1156913021836 active site 1156913021837 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1156913021838 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1156913021839 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1156913021840 putative active site [active] 1156913021841 Domain of unknown function (DUF3404); Region: DUF3404; pfam11884 1156913021842 putative acetyltransferase; Provisional; Region: PRK03624 1156913021843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913021844 Coenzyme A binding pocket [chemical binding]; other site 1156913021845 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 1156913021846 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1156913021847 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913021848 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1156913021849 Protein of unknown function (DUF419); Region: DUF419; cl15265 1156913021850 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1156913021851 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1156913021852 putative active site [active] 1156913021853 putative metal binding site [ion binding]; other site 1156913021854 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1156913021855 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1156913021856 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1156913021857 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 1156913021858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913021859 Coenzyme A binding pocket [chemical binding]; other site 1156913021860 VanZ like family; Region: VanZ; pfam04892 1156913021861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913021862 S-adenosylmethionine binding site [chemical binding]; other site 1156913021863 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1156913021864 active site 1156913021865 SUMO-1 interface [polypeptide binding]; other site 1156913021866 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913021867 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913021868 DNA binding residues [nucleotide binding] 1156913021869 dimerization interface [polypeptide binding]; other site 1156913021870 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1156913021871 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1156913021872 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1156913021873 FAD binding site [chemical binding]; other site 1156913021874 substrate binding site [chemical binding]; other site 1156913021875 catalytic residues [active] 1156913021876 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1156913021877 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1156913021878 Predicted membrane protein [Function unknown]; Region: COG2261 1156913021879 Leucine rich repeat; Region: LRR_8; pfam13855 1156913021880 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1156913021881 Leucine-rich repeats; other site 1156913021882 Substrate binding site [chemical binding]; other site 1156913021883 Leucine rich repeat; Region: LRR_8; pfam13855 1156913021884 Leucine rich repeat; Region: LRR_8; pfam13855 1156913021885 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1156913021886 VanW like protein; Region: VanW; pfam04294 1156913021887 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1156913021888 oligomerisation interface [polypeptide binding]; other site 1156913021889 mobile loop; other site 1156913021890 roof hairpin; other site 1156913021891 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1156913021892 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1156913021893 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1156913021894 hydrophobic ligand binding site; other site 1156913021895 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1156913021896 EspG family; Region: ESX-1_EspG; pfam14011 1156913021897 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1156913021898 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1156913021899 Walker A/P-loop; other site 1156913021900 ATP binding site [chemical binding]; other site 1156913021901 Q-loop/lid; other site 1156913021902 ABC transporter signature motif; other site 1156913021903 Walker B; other site 1156913021904 D-loop; other site 1156913021905 H-loop/switch region; other site 1156913021906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1156913021907 dimer interface [polypeptide binding]; other site 1156913021908 conserved gate region; other site 1156913021909 putative PBP binding loops; other site 1156913021910 ABC-ATPase subunit interface; other site 1156913021911 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1156913021912 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1156913021913 substrate binding pocket [chemical binding]; other site 1156913021914 membrane-bound complex binding site; other site 1156913021915 hinge residues; other site 1156913021916 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1156913021917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1156913021918 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1156913021919 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1156913021920 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1156913021921 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1156913021922 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913021923 ABC-ATPase subunit interface; other site 1156913021924 dimer interface [polypeptide binding]; other site 1156913021925 putative PBP binding regions; other site 1156913021926 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1156913021927 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1156913021928 ABC-ATPase subunit interface; other site 1156913021929 dimer interface [polypeptide binding]; other site 1156913021930 putative PBP binding regions; other site 1156913021931 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1156913021932 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1156913021933 intersubunit interface [polypeptide binding]; other site 1156913021934 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913021935 hypothetical protein; Provisional; Region: PRK07907 1156913021936 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 1156913021937 metal binding site [ion binding]; metal-binding site 1156913021938 putative dimer interface [polypeptide binding]; other site 1156913021939 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1156913021940 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1156913021941 TPP-binding site [chemical binding]; other site 1156913021942 heterodimer interface [polypeptide binding]; other site 1156913021943 tetramer interface [polypeptide binding]; other site 1156913021944 phosphorylation loop region [posttranslational modification] 1156913021945 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1156913021946 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1156913021947 alpha subunit interface [polypeptide binding]; other site 1156913021948 TPP binding site [chemical binding]; other site 1156913021949 heterodimer interface [polypeptide binding]; other site 1156913021950 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1156913021951 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1156913021952 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1156913021953 E3 interaction surface; other site 1156913021954 lipoyl attachment site [posttranslational modification]; other site 1156913021955 e3 binding domain; Region: E3_binding; pfam02817 1156913021956 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1156913021957 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913021958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913021959 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1156913021960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913021961 Walker A/P-loop; other site 1156913021962 ATP binding site [chemical binding]; other site 1156913021963 Q-loop/lid; other site 1156913021964 ABC transporter signature motif; other site 1156913021965 Walker B; other site 1156913021966 D-loop; other site 1156913021967 H-loop/switch region; other site 1156913021968 topology modulation protein; Reviewed; Region: PRK08118 1156913021969 AAA domain; Region: AAA_17; pfam13207 1156913021970 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1156913021971 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1156913021972 Divergent AAA domain; Region: AAA_4; pfam04326 1156913021973 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1156913021974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913021975 putative DNA binding site [nucleotide binding]; other site 1156913021976 putative Zn2+ binding site [ion binding]; other site 1156913021977 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1156913021978 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1156913021979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913021980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913021981 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1156913021982 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1156913021983 active site 2 [active] 1156913021984 active site 1 [active] 1156913021985 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1156913021986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913021987 NAD(P) binding site [chemical binding]; other site 1156913021988 active site 1156913021989 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1156913021990 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1156913021991 dimer interface [polypeptide binding]; other site 1156913021992 active site 1156913021993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913021994 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1156913021995 Walker A/P-loop; other site 1156913021996 ATP binding site [chemical binding]; other site 1156913021997 Q-loop/lid; other site 1156913021998 ABC transporter signature motif; other site 1156913021999 Walker B; other site 1156913022000 D-loop; other site 1156913022001 H-loop/switch region; other site 1156913022002 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1156913022003 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1156913022004 YCII-related domain; Region: YCII; cl00999 1156913022005 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1156913022006 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1156913022007 active site 1156913022008 catalytic site [active] 1156913022009 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1156913022010 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1156913022011 DNA binding residues [nucleotide binding] 1156913022012 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1156913022013 AAA ATPase domain; Region: AAA_16; pfam13191 1156913022014 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1156913022015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1156913022016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913022017 Coenzyme A binding pocket [chemical binding]; other site 1156913022018 YCII-related domain; Region: YCII; cl00999 1156913022019 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1156913022020 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1156913022021 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1156913022022 Na binding site [ion binding]; other site 1156913022023 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1156913022024 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1156913022025 TAP-like protein; Region: Abhydrolase_4; pfam08386 1156913022026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1156913022027 sequence-specific DNA binding site [nucleotide binding]; other site 1156913022028 salt bridge; other site 1156913022029 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1156913022030 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1156913022031 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1156913022032 Walker A/P-loop; other site 1156913022033 ATP binding site [chemical binding]; other site 1156913022034 Q-loop/lid; other site 1156913022035 ABC transporter signature motif; other site 1156913022036 Walker B; other site 1156913022037 D-loop; other site 1156913022038 H-loop/switch region; other site 1156913022039 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1156913022040 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913022041 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1156913022042 active site 1156913022043 substrate-binding site [chemical binding]; other site 1156913022044 metal-binding site [ion binding] 1156913022045 GTP binding site [chemical binding]; other site 1156913022046 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1156913022047 Dynamin family; Region: Dynamin_N; pfam00350 1156913022048 G1 box; other site 1156913022049 GTP/Mg2+ binding site [chemical binding]; other site 1156913022050 G2 box; other site 1156913022051 Switch I region; other site 1156913022052 G3 box; other site 1156913022053 Switch II region; other site 1156913022054 G4 box; other site 1156913022055 G5 box; other site 1156913022056 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 1156913022057 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1156913022058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913022059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913022060 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1156913022061 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1156913022062 Dynamin family; Region: Dynamin_N; pfam00350 1156913022063 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1156913022064 G1 box; other site 1156913022065 GTP/Mg2+ binding site [chemical binding]; other site 1156913022066 G2 box; other site 1156913022067 Switch I region; other site 1156913022068 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913022069 Histidine kinase; Region: HisKA_3; pfam07730 1156913022070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913022071 ATP binding site [chemical binding]; other site 1156913022072 Mg2+ binding site [ion binding]; other site 1156913022073 G-X-G motif; other site 1156913022074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913022075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913022076 active site 1156913022077 phosphorylation site [posttranslational modification] 1156913022078 intermolecular recognition site; other site 1156913022079 dimerization interface [polypeptide binding]; other site 1156913022080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913022081 DNA binding residues [nucleotide binding] 1156913022082 dimerization interface [polypeptide binding]; other site 1156913022083 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913022084 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913022085 active site 1156913022086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913022087 short chain dehydrogenase; Provisional; Region: PRK08303 1156913022088 NAD(P) binding site [chemical binding]; other site 1156913022089 active site 1156913022090 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913022091 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1156913022092 Walker A/P-loop; other site 1156913022093 ATP binding site [chemical binding]; other site 1156913022094 Q-loop/lid; other site 1156913022095 ABC transporter signature motif; other site 1156913022096 Walker B; other site 1156913022097 D-loop; other site 1156913022098 H-loop/switch region; other site 1156913022099 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1156913022100 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1156913022101 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1156913022102 Walker A/P-loop; other site 1156913022103 ATP binding site [chemical binding]; other site 1156913022104 Q-loop/lid; other site 1156913022105 ABC transporter signature motif; other site 1156913022106 Walker B; other site 1156913022107 D-loop; other site 1156913022108 H-loop/switch region; other site 1156913022109 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1156913022110 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1156913022111 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1156913022112 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1156913022113 Walker A/P-loop; other site 1156913022114 ATP binding site [chemical binding]; other site 1156913022115 Q-loop/lid; other site 1156913022116 ABC transporter signature motif; other site 1156913022117 Walker B; other site 1156913022118 D-loop; other site 1156913022119 H-loop/switch region; other site 1156913022120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913022121 Histidine kinase; Region: HisKA_3; pfam07730 1156913022122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913022123 ATP binding site [chemical binding]; other site 1156913022124 Mg2+ binding site [ion binding]; other site 1156913022125 G-X-G motif; other site 1156913022126 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913022127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913022128 active site 1156913022129 phosphorylation site [posttranslational modification] 1156913022130 intermolecular recognition site; other site 1156913022131 dimerization interface [polypeptide binding]; other site 1156913022132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913022133 DNA binding residues [nucleotide binding] 1156913022134 dimerization interface [polypeptide binding]; other site 1156913022135 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1156913022136 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1156913022137 active site 1156913022138 putative substrate binding pocket [chemical binding]; other site 1156913022139 short chain dehydrogenase; Provisional; Region: PRK08219 1156913022140 classical (c) SDRs; Region: SDR_c; cd05233 1156913022141 NAD(P) binding site [chemical binding]; other site 1156913022142 active site 1156913022143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1156913022144 S-adenosylmethionine binding site [chemical binding]; other site 1156913022145 Cna protein B-type domain; Region: Cna_B; pfam05738 1156913022146 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1156913022147 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1156913022148 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1156913022149 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1156913022150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913022151 putative substrate translocation pore; other site 1156913022152 MarR family; Region: MarR; pfam01047 1156913022153 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1156913022154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913022155 motif I; other site 1156913022156 active site 1156913022157 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1156913022158 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1156913022159 Predicted transcriptional regulators [Transcription]; Region: COG1695 1156913022160 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1156913022161 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1156913022162 Transglycosylase; Region: Transgly; pfam00912 1156913022163 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1156913022164 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1156913022165 Transglycosylase; Region: Transgly; pfam00912 1156913022166 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1156913022167 putative oxidoreductase; Provisional; Region: PRK11579 1156913022168 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1156913022169 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1156913022170 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913022171 dimerization interface [polypeptide binding]; other site 1156913022172 putative DNA binding site [nucleotide binding]; other site 1156913022173 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913022174 putative Zn2+ binding site [ion binding]; other site 1156913022175 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913022176 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913022177 Predicted integral membrane protein [Function unknown]; Region: COG5650 1156913022178 endonuclease IV; Provisional; Region: PRK01060 1156913022179 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1156913022180 AP (apurinic/apyrimidinic) site pocket; other site 1156913022181 DNA interaction; other site 1156913022182 Metal-binding active site; metal-binding site 1156913022183 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1156913022184 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1156913022185 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1156913022186 dimer interface [polypeptide binding]; other site 1156913022187 ssDNA binding site [nucleotide binding]; other site 1156913022188 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1156913022189 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1156913022190 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1156913022191 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1156913022192 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1156913022193 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1156913022194 Sec24-related protein; Provisional; Region: PTZ00395 1156913022195 EspG family; Region: ESX-1_EspG; pfam14011 1156913022196 replicative DNA helicase; Region: DnaB; TIGR00665 1156913022197 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1156913022198 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1156913022199 Walker A motif; other site 1156913022200 ATP binding site [chemical binding]; other site 1156913022201 Walker B motif; other site 1156913022202 DNA binding loops [nucleotide binding] 1156913022203 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1156913022204 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1156913022205 hypothetical protein; Provisional; Region: PRK07236 1156913022206 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1156913022207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1156913022208 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1156913022209 Beta-lactamase; Region: Beta-lactamase; pfam00144 1156913022210 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1156913022211 HTH domain; Region: HTH_11; pfam08279 1156913022212 WYL domain; Region: WYL; pfam13280 1156913022213 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1156913022214 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1156913022215 active site 1156913022216 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1156913022217 MarR family; Region: MarR_2; pfam12802 1156913022218 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1156913022219 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1156913022220 putative active site [active] 1156913022221 metal binding site [ion binding]; metal-binding site 1156913022222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913022223 putative substrate translocation pore; other site 1156913022224 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1156913022225 dimerization interface [polypeptide binding]; other site 1156913022226 putative DNA binding site [nucleotide binding]; other site 1156913022227 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1156913022228 putative Zn2+ binding site [ion binding]; other site 1156913022229 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1156913022230 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1156913022231 large tegument protein UL36; Provisional; Region: PHA03247 1156913022232 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1156913022233 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913022234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1156913022235 ATP binding site [chemical binding]; other site 1156913022236 Mg2+ binding site [ion binding]; other site 1156913022237 G-X-G motif; other site 1156913022238 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1156913022239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1156913022240 active site 1156913022241 phosphorylation site [posttranslational modification] 1156913022242 intermolecular recognition site; other site 1156913022243 dimerization interface [polypeptide binding]; other site 1156913022244 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1156913022245 DNA binding residues [nucleotide binding] 1156913022246 dimerization interface [polypeptide binding]; other site 1156913022247 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1156913022248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1156913022249 putative substrate translocation pore; other site 1156913022250 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1156913022251 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1156913022252 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1156913022253 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1156913022254 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1156913022255 substrate binding site [chemical binding]; other site 1156913022256 dimer interface [polypeptide binding]; other site 1156913022257 ATP binding site [chemical binding]; other site 1156913022258 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1156913022259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1156913022260 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1156913022261 DNA-binding interface [nucleotide binding]; DNA binding site 1156913022262 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1156913022263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1156913022264 NAD(P) binding site [chemical binding]; other site 1156913022265 active site 1156913022266 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1156913022267 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1156913022268 active site 1156913022269 HIGH motif; other site 1156913022270 nucleotide binding site [chemical binding]; other site 1156913022271 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1156913022272 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1156913022273 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1156913022274 active site 1156913022275 KMSKS motif; other site 1156913022276 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1156913022277 tRNA binding surface [nucleotide binding]; other site 1156913022278 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1156913022279 SdpI/YhfL protein family; Region: SdpI; pfam13630 1156913022280 hypothetical protein; Validated; Region: PRK00228 1156913022281 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1156913022282 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1156913022283 Region found in RelA / SpoT proteins; Region: RelA_SpoT; smart00954 1156913022284 metal binding triad [ion binding]; metal-binding site 1156913022285 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1156913022286 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1156913022287 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1156913022288 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1156913022289 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1156913022290 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1156913022291 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1156913022292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1156913022293 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1156913022294 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1156913022295 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1156913022296 active site 1156913022297 NTP binding site [chemical binding]; other site 1156913022298 metal binding triad [ion binding]; metal-binding site 1156913022299 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1156913022300 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1156913022301 Zn2+ binding site [ion binding]; other site 1156913022302 Mg2+ binding site [ion binding]; other site 1156913022303 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1156913022304 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1156913022305 active site 1156913022306 Ap6A binding site [chemical binding]; other site 1156913022307 nudix motif; other site 1156913022308 metal binding site [ion binding]; metal-binding site 1156913022309 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1156913022310 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1156913022311 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1156913022312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1156913022313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1156913022314 DNA binding residues [nucleotide binding] 1156913022315 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1156913022316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1156913022317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1156913022318 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1156913022319 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1156913022320 catalytic residues [active] 1156913022321 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1156913022322 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913022323 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1156913022324 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1156913022325 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1156913022326 active site 1156913022327 metal binding site [ion binding]; metal-binding site 1156913022328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1156913022329 Coenzyme A binding pocket [chemical binding]; other site 1156913022330 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1156913022331 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1156913022332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1156913022333 homodimer interface [polypeptide binding]; other site 1156913022334 catalytic residue [active] 1156913022335 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1156913022336 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1156913022337 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1156913022338 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1156913022339 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1156913022340 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1156913022341 ParB-like nuclease domain; Region: ParBc; pfam02195 1156913022342 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1156913022343 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1156913022344 P-loop; other site 1156913022345 Magnesium ion binding site [ion binding]; other site 1156913022346 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1156913022347 Magnesium ion binding site [ion binding]; other site 1156913022348 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1156913022349 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1156913022350 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1156913022351 G-X-X-G motif; other site 1156913022352 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1156913022353 RxxxH motif; other site 1156913022354 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1156913022355 Haemolytic domain; Region: Haemolytic; pfam01809 1156913022356 Ribonuclease P; Region: Ribonuclease_P; cl00457 1156913022357 Ribosomal protein L34; Region: Ribosomal_L34; cl00370